KEGG   PATHWAY: pfa03440
Entry
pfa03440                    Pathway                                
Name
Homologous recombination - Plasmodium falciparum 3D7
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
pfa03440  Homologous recombination
pfa03440

Other DBs
GO: 0000724
Organism
Plasmodium falciparum 3D7 [GN:pfa]
Gene
PF3D7_0508800  single-stranded DNA-binding protein [KO:K03111]
PF3D7_0605800  DNA repair protein RAD50, putative [KO:K10866] [EC:3.6.-.-]
PF3D7_0107800  double-strand break repair protein MRE11 [KO:K10865]
PF3D7_0721800  conserved Plasmodium protein, unknown function [KO:K10881]
PF3D7_0409600  replication protein A1, large subunit [KO:K07466]
PF3D7_1442100  replication factor A protein 3, putative [KO:K10740]
PF3D7_1107400  DNA repair protein RAD51 [KO:K04482]
PF3D7_0803400  DNA repair and recombination protein RAD54, putative [KO:K10875] [EC:5.6.2.-]
PF3D7_1017000  DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
PF3D7_0308000  DNA polymerase delta small subunit, putative [KO:K02328]
PF3D7_0918600  ATP-dependent DNA helicase Q1 [KO:K10901] [EC:5.6.2.4]
PF3D7_1347100  DNA topoisomerase 3, putative [KO:K03165] [EC:5.6.2.1]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG GENES (12)   
All databases (13)   

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