KEGG   PATHWAY: pfa04141
Entry
pfa04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Plasmodium falciparum 3D7
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
pfa04141  Protein processing in endoplasmic reticulum
pfa04141

Other DBs
GO: 0030433 0034976
Organism
Plasmodium falciparum 3D7 [GN:pfa]
Gene
PF3D7_1346100  protein transport protein SEC61 subunit alpha [KO:K10956]
PF3D7_0821800  protein transport protein SEC61 subunit beta, putative [KO:K09481]
PF3D7_0210000  secretory complex protein 61 gamma subunit [KO:K07342]
PF3D7_1438100  translocation protein SEC62, putative [KO:K12275]
PF3D7_1318800  translocation protein SEC63, putative [KO:K09540]
PF3D7_0726800  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2, putative [KO:K12668]
PF3D7_0919600  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1, putative [KO:K12670]
PF3D7_1116600  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3, putative [KO:K07151] [EC:2.4.99.18]
PF3D7_1344200  endoplasmic reticulum chaperone GRP170 [KO:K09486]
PF3D7_0917900  heat shock protein 70 [KO:K09490] [EC:3.6.4.10]
PF3D7_1222300  endoplasmin, putative [KO:K09487]
PF3D7_0416800  small GTP-binding protein sar1 [KO:K07953] [EC:3.6.5.-]
PF3D7_1230700  protein transport protein SEC13 [KO:K14004]
PF3D7_0214100  protein transport protein SEC31 [KO:K14005]
PF3D7_0822600  protein transport protein SEC23 [KO:K14006]
PF3D7_1361100  protein transport protein Sec24A [KO:K14007]
PF3D7_0827900  protein disulfide isomerase [KO:K09580] [EC:5.3.4.1]
PF3D7_1134100  protein disulfide isomerase [KO:K09584] [EC:5.3.4.1]
PF3D7_1124000  endoplasmic reticulum oxidoreductin, putative [KO:K10950] [EC:1.8.4.-]
PF3D7_1468500.1  derlin-1 [KO:K13989]
PF3D7_1032500  DER1-like protein, putative [KO:K13989]
PF3D7_0808300  ubiquitin regulatory protein, putative [KO:K14012]
PF3D7_0619400  cell division cycle protein 48 homologue, putative [KO:K13525]
PF3D7_0507700  nuclear protein localization protein 4, putative [KO:K14015]
PF3D7_1418000  ubiquitin fusion degradation protein 1, putative [KO:K14016]
PF3D7_0524800  ubiquitin fusion degradation protein 1, putative [KO:K14016]
PF3D7_0916500  ubiquitin fusion degradation protein 1 [KO:K14016]
PF3D7_0818900  heat shock protein 70 [KO:K03283]
PF3D7_0831700  heat shock protein 70 [KO:K03283]
PF3D7_1437900  HSP40, subfamily A [KO:K09503]
PF3D7_1136800  DnaJ protein, putative [KO:K09518]
PF3D7_0708400  heat shock protein 90 [KO:K04079]
PF3D7_1304500  small heat shock protein, putative [KO:K13993]
PF3D7_1011700  DNA repair protein RAD23, putative [KO:K10839]
PF3D7_1113400  ubiquitin domain-containing protein DSK2, putative [KO:K04523]
PF3D7_1226800  ataxin-3, putative [KO:K11863] [EC:3.4.22.-]
PF3D7_0728000  eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
PF3D7_0921000.1  ubiquitin-conjugating enzyme E2, putative [KO:K10575] [EC:2.3.2.23]
PF3D7_1422500  ERAD-associated E3 ubiquitin-protein ligase HRD1 [KO:K10601] [EC:2.3.2.27]
PF3D7_0707700  E3 ubiquitin-protein ligase, putative [KO:K09561] [EC:2.3.2.27]
PF3D7_1203900  ubiquitin-conjugating enzyme E2 [KO:K06689] [EC:2.3.2.23]
PF3D7_0319100  E3 ubiquitin-protein ligase RBX1, putative [KO:K03868] [EC:2.3.2.32]
PF3D7_0811000  cullin-1, putative [KO:K03347]
PF3D7_1367000  suppressor of kinetochore protein 1, putative [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
pfa00510  N-Glycan biosynthesis
pfa03050  Proteasome
pfa03060  Protein export
KO pathway
ko04141   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (44)   
   KEGG GENES (44)   
All databases (45)   

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