KEGG   PATHWAY: pkn03013
Entry
pkn03013                    Pathway                                
Name
Nucleocytoplasmic transport - Plasmodium knowlesi
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
pkn03013  Nucleocytoplasmic transport
pkn03013

Other DBs
GO: 0050658
Organism
Plasmodium knowlesi [GN:pkn]
Gene
PKNH_1222800  ATP-dependent RNA helicase DBP5, putative [KO:K18655] [EC:5.6.2.7]
PKNH_0713100  SUMO-conjugating enzyme UBC9, putative [KO:K10577]
PKNH_1450100  protein transport protein SEC13, putative [KO:K14004]
PKNH_0303700  TMEM33 domain-containing protein, putative [KO:K20724]
PKNH_1428200  karyopherin alpha, putative [KO:K15042]
PKNH_1425100  importin subunit beta, putative [KO:K14293]
PKNH_1122100  transportin, putative [KO:K18752]
PKNH_1008900  karyopherin beta, putative [KO:K20222]
PKNH_0104500  importin-7, putative [KO:K20223]
PKNH_0840200  exportin-1, putative [KO:K14290]
PKNH_0731500  importin alpha re-exporter, putative [KO:K18423]
PKNH_1416600  exportin-T, putative [KO:K14288]
PKNH_0708100  uncharacterized protein [KO:K18460]
PKNH_0915400  GTP-binding nuclear protein RAN/TC4, putative [KO:K07936]
PKNH_1114400  elongation factor 1-alpha, putative [KO:K03231]
PKNH_1114500  elongation factor 1-alpha [KO:K03231]
PKNH_0507100  nuclear cap-binding protein subunit 2, putative [KO:K12883]
PKNH_0213900  NMD3-like protein [KO:K07562]
PKNH_1352100  RNA-binding protein 8A, putative [KO:K12876]
PKNH_0320600  mago nashi protein homologue, putative [KO:K12877]
PKNH_0514600  eukaryotic initiation factor 4A-III, putative [KO:K13025] [EC:5.6.2.7]
PKNH_1134300  RNA and export factor binding protein, putative [KO:K12881]
PKNH_0804200  regulator of nonsense transcripts 1, putative [KO:K14326] [EC:5.6.2.5 5.6.2.3]
PKNH_0723700  armadillo repeat protein, putative [KO:K14327]
PKNH_1200900  regulator of nonsense transcripts 3B, putative [KO:K14328]
PKNH_0411300  ATP-dependent RNA helicase UAP56, putative [KO:K12812] [EC:5.6.2.7]
PKNH_1308900  mago-binding protein, putative [KO:K14294]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
pkn03015  mRNA surveillance pathway
KO pathway
ko03013   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG GENES (27)   
All databases (28)   

Download RDF
DBGET integrated database retrieval system