KEGG   PATHWAY: pkn04141
Entry
pkn04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Plasmodium knowlesi
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
pkn04141  Protein processing in endoplasmic reticulum
pkn04141

Other DBs
GO: 0030433 0034976
Organism
Plasmodium knowlesi [GN:pkn]
Gene
PKNH_1255200  protein transport protein SEC61 subunit alpha, putative [KO:K10956]
PKNH_1315800  protein transport protein SEC61 subunit beta, putative [KO:K09481]
PKNH_0411200  Sec61-gamma subunit of protein translocation, putative [KO:K07342]
PKNH_1244300  translocation protein SEC62, putative [KO:K12275]
PKNH_1419600  DNAJ-like Sec63-like protein [KO:K09540]
PKNH_0211400  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2, putative [KO:K12668]
PKNH_0717600  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1, putative [KO:K12670]
PKNH_0914300  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3, putative [KO:K07151] [EC:2.4.99.18]
PKNH_1257200  endoplasmic reticulum chaperone GRP170, putative [KO:K09486]
PKNH_0715900  endoplasmic reticulum chaperone BiP, putative [KO:K09490] [EC:3.6.4.10]
PKNH_1441400  endoplasmin, putative [KO:K09487]
PKNH_0509200  small GTP-binding protein sar1, putative [KO:K07953] [EC:3.6.5.-]
PKNH_1450100  protein transport protein SEC13, putative [KO:K14004]
PKNH_0406700  uncharacterized protein [KO:K14005]
PKNH_1316600  protein transport protein SEC23, putative [KO:K14006]
PKNH_1110300  protein transport protein Sec24A, putative [KO:K14007]
PKNH_1322000  protein disulfide isomerase, putative [KO:K09580] [EC:5.3.4.1]
PKNH_0932300  protein disulfide-isomerase, putative [KO:K09584] [EC:5.3.4.1]
PKNH_0921800  endoplasmic reticulum oxidoreductin, putative [KO:K10950] [EC:1.8.4.-]
PKNH_0617300  DER1-like protein, putative [KO:K13989]
PKNH_1212700  derlin-1, putative [KO:K13989]
PKNH_0110400  ubiquitin regulatory protein, putative [KO:K14012]
PKNH_1131000  cell division cycle protein 48-like protein [KO:K13525]
PKNH_1025900  nuclear protein localization protein 4, putative [KO:K14015]
PKNH_1008100  ubiquitin fusion degradation protein 1, putative [KO:K14016]
PKNH_0714500  ubiquitin fusion degradation protein 1, putative [KO:K14016]
PKNH_1340000  ubiquitin fusion degradation protein 1, putative [KO:K14016]
PKNH_1312700  heat shock protein 70, putative [KO:K03283]
PKNH_0424600  HSP40, subfamily A, putative [KO:K09503]
PKNH_0935000  DnaJ protein, putative [KO:K09518]
PKNH_0107000  heat shock protein 90, putative [KO:K04079]
PKNH_1404700  small heat shock protein, putative [KO:K13993]
PKNH_0811500  DNA repair protein RAD23, putative [KO:K10839]
PKNH_0911000  ubiquitin domain-containing protein DSK2, putative [KO:K04523]
PKNH_0930200  ubiquitin-like protein, putative [KO:K04523]
PKNH_1446200  uncharacterized protein [KO:K11863] [EC:3.4.22.-]
PKNH_0212600  eukaryotic translation initiation factor 2 subunit alpha, putative [KO:K03237]
PKNH_0719000  ubiquitin-conjugating enzyme E2, putative [KO:K10575] [EC:2.3.2.23]
PKNH_1335500  ERAD-associated E3 ubiquitin-protein ligase HRD1, putative [KO:K10601] [EC:2.3.2.27]
PKNH_0106200  E3 ubiquitin-protein ligase, putative [KO:K09561] [EC:2.3.2.27]
PKNH_1303600  ubiquitin-conjugating enzyme E2, putative [KO:K06689] [EC:2.3.2.23]
PKNH_0822400  E3 ubiquitin-protein ligase RBX1, putative [KO:K03868] [EC:2.3.2.32]
PKNH_1429700  cullin-1, putative [KO:K03347]
PKNH_1104200  suppressor of kinetochore protein 1, putative [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
pkn00510  N-Glycan biosynthesis
pkn03050  Proteasome
pkn03060  Protein export
KO pathway
ko04141   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (44)   
   KEGG GENES (44)   
All databases (45)   

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