KEGG   PATHWAY: pyo03013
Entry
pyo03013                    Pathway                                
Name
Nucleocytoplasmic transport - Plasmodium yoelii
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
pyo03013  Nucleocytoplasmic transport
pyo03013

Other DBs
GO: 0050658
Organism
Plasmodium yoelii [GN:pyo]
Gene
PY17X_1326500  ATP-dependent RNA helicase DBP5, putative [KO:K18655] [EC:5.6.2.7]
PY17X_0819400  SUMO-conjugating enzyme UBC9, putative [KO:K10577]
PY17X_1447900  protein transport protein SEC13, putative [KO:K14004]
PY17X_1004700  TMEM33 domain-containing protein, putative [KO:K20724]
PY17X_1427100  karyopherin alpha, putative [KO:K15042]
PY17X_1424400  importin subunit beta-1 [KO:K14293]
PY17X_1127900  transportin [KO:K18752]
PY17X_1242000  karyopherin beta, putative [KO:K20222]
PY17X_0806300  uncharacterized protein [KO:K20223]
PY17X_0403700  uncharacterized protein [KO:K14290]
PY17X_0837000  importin alpha re-exporter, putative [KO:K18423]
PY17X_1416100  exportin-T, putative [KO:K14288]
PY17X_0814600  exportin-7, putative [KO:K18460]
PY17X_0932300  GTP-binding nuclear protein RAN/TC4 [KO:K07936]
PY17X_1134900  elongation factor 1-alpha, putative [KO:K03231]
PY17X_1134800  elongation factor 1-alpha, putative [KO:K03231]
PY17X_0717700  nuclear cap-binding protein subunit 2, putative [KO:K12883]
PY17X_0214800  60S ribosomal export protein NMD3, putative [KO:K07562]
PY17X_1038600  RNA-binding protein 8A, putative [KO:K12876]
PY17X_0625400  mago nashi protein homologue, putative [KO:K12877]
PY17X_0524500  eukaryotic initiation factor 4A-III, putative [KO:K13025] [EC:5.6.2.7]
PY17X_1233900  RNA and export factor binding protein, putative [KO:K12881]
PY17X_1206900  nonsense mRNA reducing factor 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
PY17X_0829900  armadillo repeat protein, putative [KO:K14327]
PY17X_1347600  uncharacterized protein [KO:K14328]
PY17X_0307400  ATP-dependent RNA helicase UAP56, putative [KO:K12812] [EC:5.6.2.7]
PY17X_0411600  uncharacterized protein [KO:K13171]
PY17X_0610000  mago-binding protein, putative [KO:K14294]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
pyo03015  mRNA surveillance pathway
KO pathway
ko03013   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG GENES (28)   
All databases (29)   

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