KEGG   PATHWAY: pyo04141
Entry
pyo04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Plasmodium yoelii
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
pyo04141  Protein processing in endoplasmic reticulum
pyo04141

Other DBs
GO: 0030433 0034976
Organism
Plasmodium yoelii [GN:pyo]
Gene
PY17X_1364700  uncharacterized protein [KO:K10956]
PY17X_0709200  protein transport protein SEC61 subunit beta, putative [KO:K09481]
PY17X_0307500  protein translocase SEC61 complex subunit gamma [KO:K07342]
PY17X_1305800  translocation protein SEC62, putative [KO:K12275]
PY17X_1419000  uncharacterized protein [KO:K09540]
PY17X_0212300  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2, putative [KO:K12668]
PY17X_0823800  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1, putative [KO:K12670]
PY17X_0933400  uncharacterized protein [KO:K07151] [EC:2.4.99.18]
PY17X_1362900  uncharacterized protein [KO:K09486]
PY17X_0822200  endoplasmic reticulum chaperone BiP, putative [KO:K09490] [EC:3.6.4.10]
PY17X_1439800  endoplasmin, putative [KO:K09487]
PY17X_0718900  small GTP-binding protein sar1, putative [KO:K07953] [EC:3.6.5.-]
PY17X_1447900  protein transport protein SEC13, putative [KO:K14004]
PY17X_0311500  protein transport protein SEC31, putative [KO:K14005]
PY17X_0708300  protein transport protein SEC23, putative [KO:K14006]
PY17X_1138600  protein transport protein Sec24A, putative [KO:K14007]
PY17X_0703100  protein disulfide isomerase, putative [KO:K09580] [EC:5.3.4.1]
PY17X_0915800  thioredoxin [KO:K09584] [EC:5.3.4.1]
PY17X_0926300  endoplasmic reticulum oxidoreductin, putative [KO:K10950] [EC:1.8.4.-]
PY17X_1336500  derlin-1, putative [KO:K13989]
PY17X_0517400  uncharacterized protein [KO:K13989]
PY17X_1225600  ubiquitin regulatory protein, putative [KO:K14012]
PY17X_1119700  cell division cycle protein 48 [KO:K13525]
PY17X_1108400  uncharacterized protein [KO:K14015]
PY17X_1027100  ubiquitin fusion degradation protein 1, putative [KO:K14016]
PY17X_1242800  ubiquitin fusion degradation protein 1, putative [KO:K14016]
PY17X_0820800  ubiquitin fusion degradation protein 1, putative [KO:K14016]
PY17X_0712100  heat shock protein 70, putative [KO:K03283]
PY17X_0613400  uncharacterized protein [KO:K09503]
PY17X_0913300  DnaJ protein, putative [KO:K09518]
PY17X_0808800  heat shock protein 90, putative [KO:K04079]
PY17X_1009600  conserved protein, unknown function [KO:K09562]
PY17X_1404600  small heat shock protein, putative [KO:K13993]
PY17X_0714500  small heat shock protein HSP20, putative [KO:K13993]
PY17X_1213300  DNA repair protein RAD23, putative [KO:K10839]
PY17X_0936200  ubiquitin-like protein Dsk2 [KO:K04523]
PY17X_0917900  ubiquitin-like protein, putative [KO:K04523]
PY17X_1444100  ataxin-3, putative [KO:K11863] [EC:3.4.22.-]
PY17X_0213500  eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
PY17X_0825200  ubiquitin-conjugating enzyme E2, putative [KO:K10575] [EC:2.3.2.23]
PY17X_1022800  ERAD-associated E3 ubiquitin-protein ligase HRD1, putative [KO:K10601] [EC:2.3.2.27]
PY17X_0808000  erythrocyte membrane protein [KO:K09561] [EC:2.3.2.27]
PY17X_0605300  ubiquitin-conjugating enzyme E2, putative [KO:K06689] [EC:2.3.2.23]
PY17X_0809400  uncharacterized protein [KO:K03868] [EC:2.3.2.32]
PY17X_1428600  cullin-1, putative [KO:K03347]
PY17X_1144200  suppressor of kinetochore protein 1, putative [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
pyo00510  N-Glycan biosynthesis
pyo03050  Proteasome
pyo03060  Protein export
KO pathway
ko04141   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (46)   
   KEGG GENES (46)   
All databases (47)   

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