KEGG   PATHWAY: sce00010
Entry
sce00010                    Pathway                                

Name
Glycolysis / Gluconeogenesis - Saccharomyces cerevisiae (budding yeast)
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
sce00010  Glycolysis / Gluconeogenesis
sce00010

Module
sce_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:sce00010]
sce_M00002  Glycolysis, core module involving three-carbon compounds [PATH:sce00010]
sce_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:sce00010]
sce_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:sce00010]
Other DBs
GO: 0006096 0006094
Organism
Saccharomyces cerevisiae (budding yeast) [GN:sce]
Gene
YGL253W  HXK2; hexokinase 2 [KO:K00844] [EC:2.7.1.1]
YFR053C  HXK1; hexokinase 1 [KO:K00844] [EC:2.7.1.1]
YCL040W  GLK1; glucokinase [KO:K00844] [EC:2.7.1.1]
YDR516C  EMI2; putative glucokinase [KO:K00844] [EC:2.7.1.1]
YLR446W  hexokinase [KO:K00844] [EC:2.7.1.1]
YBR196C  PGI1; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
YMR205C  PFK2; 6-phosphofructokinase subunit beta [KO:K00850] [EC:2.7.1.11]
YGR240C  PFK1; 6-phosphofructokinase subunit alpha [KO:K00850] [EC:2.7.1.11]
YLR377C  FBP1; fructose 1,6-bisphosphate 1-phosphatase [KO:K03841] [EC:3.1.3.11]
YKL060C  FBA1; fructose-bisphosphate aldolase FBA1 [KO:K01624] [EC:4.1.2.13]
YDR050C  TPI1; triose-phosphate isomerase TPI1 [KO:K01803] [EC:5.3.1.1]
YGR192C  TDH3; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 [KO:K00134] [EC:1.2.1.12]
YJL052W  TDH1; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1 [KO:K00134] [EC:1.2.1.12]
YJR009C  TDH2; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 [KO:K00134] [EC:1.2.1.12]
YCR012W  PGK1; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
YDL021W  GPM2; phosphoglycerate mutase family protein GPM2 [KO:K01834] [EC:5.4.2.11]
YKL152C  GPM1; phosphoglycerate mutase GPM1 [KO:K01834] [EC:5.4.2.11]
YOL056W  GPM3; phosphoglycerate mutase family protein GPM3 [KO:K01834] [EC:5.4.2.11]
YMR323W  ERR3; phosphopyruvate hydratase ERR3 [KO:K01689] [EC:4.2.1.11]
YGR254W  ENO1; phosphopyruvate hydratase ENO1 [KO:K01689] [EC:4.2.1.11]
YHR174W  ENO2; phosphopyruvate hydratase ENO2 [KO:K01689] [EC:4.2.1.11]
YOR393W  ERR1; phosphopyruvate hydratase ERR1 [KO:K01689] [EC:4.2.1.11]
YPL281C  ERR2; phosphopyruvate hydratase ERR2 [KO:K01689] [EC:4.2.1.11]
YAL038W  CDC19; pyruvate kinase CDC19 [KO:K00873] [EC:2.7.1.40]
YOR347C  PYK2; pyruvate kinase PYK2 [KO:K00873] [EC:2.7.1.40]
YER178W  PDA1; pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha [KO:K00161] [EC:1.2.4.1]
YBR221C  PDB1; pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta [KO:K00162] [EC:1.2.4.1]
YNL071W  LAT1; dihydrolipoyllysine-residue acetyltransferase [KO:K00627] [EC:2.3.1.12]
YFL018C  LPD1; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
YDL080C  THI3; branched-chain-2-oxoacid decarboxylase THI3 [KO:K01568] [EC:4.1.1.1]
YGR087C  PDC6; indolepyruvate decarboxylase 6 [KO:K01568] [EC:4.1.1.1]
YLR044C  PDC1; indolepyruvate decarboxylase 1 [KO:K01568] [EC:4.1.1.1]
YLR134W  PDC5; indolepyruvate decarboxylase 5 [KO:K01568] [EC:4.1.1.1]
YDL168W  SFA1; bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase [KO:K00121] [EC:1.1.1.284 1.1.1.1]
YOL086C  ADH1; alcohol dehydrogenase ADH1 [KO:K13953] [EC:1.1.1.1]
YMR303C  ADH2; alcohol dehydrogenase ADH2 [KO:K13953] [EC:1.1.1.1]
YBR145W  ADH5; alcohol dehydrogenase ADH5 [KO:K13953] [EC:1.1.1.1]
YMR083W  ADH3; alcohol dehydrogenase ADH3 [KO:K13953] [EC:1.1.1.1]
YGL256W  ADH4; alcohol dehydrogenase ADH4 [KO:K13954] [EC:1.1.1.1]
YCR105W  ADH7; NADP-dependent alcohol dehydrogenase [KO:K00002] [EC:1.1.1.2]
YMR318C  ADH6; NADP-dependent alcohol dehydrogenase [KO:K00002] [EC:1.1.1.2]
YOR374W  ALD4; aldehyde dehydrogenase (NADP(+)) ALD4 [KO:K00128] [EC:1.2.1.3]
YPL061W  ALD6; aldehyde dehydrogenase (NADP(+)) ALD6 [KO:K00128] [EC:1.2.1.3]
YER073W  ALD5; aldehyde dehydrogenase (NAD(P)(+)) ALD5 [KO:K00128] [EC:1.2.1.3]
YMR110C  HFD1; hexadecenal dehydrogenase [KO:K00128] [EC:1.2.1.3]
YMR169C  ALD3; aldehyde dehydrogenase (NAD(+)) ALD3 [KO:K00128] [EC:1.2.1.3]
YMR170C  ALD2; aldehyde dehydrogenase (NAD(+)) ALD2 [KO:K00128] [EC:1.2.1.3]
YAL054C  ACS1; acetate--CoA ligase 1 [KO:K01895] [EC:6.2.1.1]
YLR153C  ACS2; acetate--CoA ligase ACS2 [KO:K01895] [EC:6.2.1.1]
YBR019C  GAL10; bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase [KO:K01784 K01785] [EC:5.1.3.2 5.1.3.3]
YMR105C  PGM2; phosphoglucomutase PGM2 [KO:K01835] [EC:5.4.2.2]
YKL127W  PGM1; phosphoglucomutase PGM1 [KO:K01835] [EC:5.4.2.2]
YMR278W  PRM15; phosphoribomutase PRM15 [KO:K01835] [EC:5.4.2.2]
YMR099C  glucose-6-phosphate 1-epimerase [KO:K01792] [EC:5.1.3.15]
YKR097W  PCK1; phosphoenolpyruvate carboxykinase PCK1 [KO:K01610] [EC:4.1.1.49]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
(map 1)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 1)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
sce00020  Citrate cycle (TCA cycle)
sce00030  Pentose phosphate pathway
sce00500  Starch and sucrose metabolism
sce00620  Pyruvate metabolism
sce00640  Propanoate metabolism
KO pathway
ko00010   

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