KEGG   PATHWAY: sjp03440
Entry
sjp03440                    Pathway                                
Name
Homologous recombination - Sphingobium indicum UT26S
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
sjp03440  Homologous recombination
sjp03440

Other DBs
GO: 0000724
Organism
Sphingobium indicum UT26S [GN:sjp]
Gene
SJA_C1-32130  recJ; single-stranded DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
SJA_C1-04320  single-stranded DNA-binding protein [KO:K03111]
SJA_C1-20180  ssb; single-stranded DNA-binding protein [KO:K03111]
SJA_C1-02990  ssb; single-stranded DNA-binding protein [KO:K03111]
SJA_C2-04700  single-stranded DNA-binding protein [KO:K03111]
SJA_P1-02230  single-stranded DNA-binding protein [KO:K03111]
SJA_C1-08960  recF; DNA replication and repair protein RecF [KO:K03629]
SJA_C1-22390  recO; DNA repair protein RecO [KO:K03584]
SJA_C1-24540  recR; recombination protein RecR [KO:K06187]
SJA_C1-32810  recA; recombination protein RecA [KO:K03553]
SJA_C1-33240  dpo1; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
SJA_C1-00990  ruvA; Holliday junction resolvasome DNA-binding subunit [KO:K03550]
SJA_C1-01010  ruvB; Holliday junction resolvasome helicase subunit [KO:K03551] [EC:5.6.2.4]
SJA_C1-33570  ruvC; crossover junction endodeoxyribonuclease [KO:K01159] [EC:3.1.21.10]
SJA_C1-14210  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
SJA_C1-17390  dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
SJA_C1-09100  dnaN; DNA polymerase III beta subunit [KO:K02338] [EC:2.7.7.7]
SJA_C1-21710  dnaX; DNA polymerase III gamma and tau subunit [KO:K02343] [EC:2.7.7.7]
SJA_C1-00400  DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
SJA_C1-16610  holB; DNA polymerase III delta' subunit [KO:K02341] [EC:2.7.7.7]
SJA_C1-00050  dnaQ; DNA polymerase III epsilon subunit [KO:K02342] [EC:2.7.7.7]
SJA_C1-25510  DNA polymerase III chi subunit [KO:K02339] [EC:2.7.7.7]
SJA_C1-26780  priA; primosomal protein N' [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG GENES (23)   
All databases (24)   

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