KEGG   PATHWAY: sma00760
Entry
sma00760                    Pathway                                
Name
Nicotinate and nicotinamide metabolism - Streptomyces avermitilis
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
sma00760  Nicotinate and nicotinamide metabolism
sma00760

Module
sma_M00115  NAD biosynthesis, aspartate => quinolinate => NAD [PATH:sma00760]
Other DBs
UMBBD: nic
GO: 0046497 0006769
Organism
Streptomyces avermitilis [GN:sma]
Gene
SAVERM_4688  nadB; putative L-aspartate oxidase [KO:K00278] [EC:1.4.3.16]
SAVERM_6041  nadA; putative quinolinate synthetase [KO:K03517] [EC:2.5.1.72]
SAVERM_4689  nadC; putative nicotinate-nucleotide pyrophosphorylase [KO:K00767] [EC:2.4.2.19]
SAVERM_5158  pncB; putative nicotinate phosphoribosyltransferase [KO:K00763] [EC:6.3.4.21]
SAVERM_3342  deoD; putative purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
SAVERM_4057  ushA; putative 5'-nucleotidase, secreted [KO:K01081] [EC:3.1.3.5]
SAVERM_5214  nagD; putative N-acetyl-glucosamine catabolism protein [KO:K02566] [EC:3.1.3.5]
SAVERM_5478  nadD; putative nicotinate-nucleotide adenylyltransferase [KO:K00969] [EC:2.7.7.18]
SAVERM_3074  hypothetical protein [KO:K03426] [EC:3.6.1.22]
SAVERM_5948  nadE; putative NH(3)-dependent NAD(+) synthetase [KO:K01950] [EC:6.3.5.1]
SAVERM_2506  cinA; putative competence-damage inducible protein [KO:K03743] [EC:3.5.1.42]
SAVERM_5157  pncA; putative nicotinamidase [KO:K08281] [EC:3.5.1.19 3.5.1.-]
SAVERM_6497  ppnK2; putative inorganic polyphosphate/ATP-NAD kinase [KO:K00858] [EC:2.7.1.23]
SAVERM_1035  ppnK1; putative inorganic polyphosphate/ATP-NAD kinase [KO:K00858] [EC:2.7.1.23]
SAVERM_404  pntA; putative pyridine nucleotide transhydrogenase, alpha subunit [KO:K00324] [EC:7.1.1.1]
SAVERM_403  pntB; putative pyridine nucleotide transhydrogenase, beta subunit [KO:K00325] [EC:7.1.1.1]
SAVERM_5234  putative decarboxylase [KO:K01799] [EC:5.2.1.1]
SAVERM_7134  gabD2; putative succinate-semialdehyde dehydrogenase, NADP-dependent [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
SAVERM_7159  gabD3; putative succinate-semialdehyde dehydrogenase, NADP-dependent [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
SAVERM_5016  gabD1; putative succinate-semialdehyde dehydrogenase, NADP-dependent [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
Compound
C00003  NAD+
C00006  NADP+
C00022  Pyruvate
C00042  Succinate
C00049  L-Aspartate
C00111  Glycerone phosphate
C00122  Fumarate
C00153  Nicotinamide
C00163  Propanoate
C00232  Succinate semialdehyde
C00253  Nicotinate
C00334  4-Aminobutanoate
C00455  Nicotinamide D-ribonucleotide
C00745  Nicotine
C00857  Deamino-NAD+
C00922  2,3-Dimethylmaleate
C01020  6-Hydroxynicotinate
C01056  (S)-6-Hydroxynicotine
C01059  2,5-Dihydroxypyridine
C01185  Nicotinate D-ribonucleotide
C01297  6-Hydroxypseudooxynicotine
C01384  Maleic acid
C01596  Maleamate
C02295  Methylitaconate
C02918  1-Methylnicotinamide
C02930  2-Methyleneglutarate
C03043  (R)-6-Hydroxynicotine
C03056  2,6-Dihydroxypyridine
C03150  Nicotinamide-beta-riboside
C03458  2,3,6-Trihydroxypyridine
C03652  (2R,3S)-2,3-Dimethylmalate
C03722  Quinolinate
C04226  6-Oxo-1,4,5,6-tetrahydronicotinate
C05380  Nicotinurate
C05840  Iminoaspartate
C05841  Nicotinate D-ribonucleoside
C05842  N1-Methyl-2-pyridone-5-carboxamide
C05843  N1-Methyl-4-pyridone-5-carboxamide
C06178  1-Methylpyrrolinium
C15523  2,6-Dihydroxynicotinate
C15986  2,6-Dihydroxypseudooxynicotine
C15987  4-Methylaminobutyrate
C16151  2,6-Dihydroxy-N-methylmyosmine
C16152  Blue pigment
C16159  2-Formylglutarate
C16386  (R)-Nicotine
C16390  (S)-2-(Hydroxymethyl)glutarate
C18232  N-Formylmaleamic acid
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19569  3-Succinoylpyridine
C19631  6-Hydroxy-3-succinoylpyridine
C20361  Pseudooxynicotine
C20381  3,3'-Bipyridine-2,2',5,5',6,6'-hexol
C21075  5-(N-Methyl-4,5-dihydro-1H-pyrrol-2-yl)pyridin-2-ol
C21154  N-Methylmyosmine
Reference
PMID:13475371
  Authors
BEHRMAN EJ, STANIER RY.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
J Biol Chem 228:923-45 (1957)
Reference
PMID:16894175
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
Reference
PMID:11514508
  Authors
Baitsch D, Sandu C, Brandsch R, Igloi GL.
  Title
Gene cluster on pAO1 of Arthrobacter nicotinovorans involved in degradation of the plant alkaloid nicotine: cloning, purification, and characterization of 2,6-dihydroxypyridine 3-hydroxylase.
  Journal
J Bacteriol 183:5262-7 (2001)
DOI:10.1128/JB.183.18.5262-5267.2001
Reference
PMID:16321959
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
Reference
PMID:5835946
  Authors
Gherna RL, Richardson SH, Rittenberg SC
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
PMID:21953451
  Authors
Galeazzi L, Bocci P, Amici A, Brunetti L, Ruggieri S, Romine M, Reed S, Osterman AL, Rodionov DA, Sorci L, Raffaelli N
  Title
Identification of nicotinamide mononucleotide deamidase of the bacterial pyridine nucleotide cycle reveals a novel broadly conserved amidohydrolase family.
  Journal
J Biol Chem 286:40365-75 (2011)
DOI:10.1074/jbc.M111.275818
Related
pathway
sma00020  Citrate cycle (TCA cycle)
sma00250  Alanine, aspartate and glutamate metabolism
sma00380  Tryptophan metabolism
sma00620  Pyruvate metabolism
sma00660  C5-Branched dibasic acid metabolism
KO pathway
ko00760   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG GENES (20)   
All databases (21)   

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