KEGG   PATHWAY: tbg03420
Entry
tbg03420                    Pathway                                
Name
Nucleotide excision repair - Trypanosoma brucei gambiense
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
tbg03420  Nucleotide excision repair
tbg03420

Other DBs
GO: 0006289
Organism
Trypanosoma brucei gambiense [GN:tbg]
Gene
TbgDal_V5200  hypothetical protein, conserved [KO:K03868] [EC:2.3.2.32]
TbgDal_X2190  hypothetical protein, conserved [KO:K03868] [EC:2.3.2.32]
TbgDal_X9640  hypothetical protein, unlikely [KO:K03868] [EC:2.3.2.32]
TbgDal_IX7210  DNA-repair protein, putative [KO:K10838]
TbgDal_VI4470  UV excision repair RAD23 protein, putative [KO:K10839]
TbgDal_VII4570  DNA excision repair protein, putative [KO:K10841]
TbgDal_IV5210  RNA polymerase IIA largest subunit, putative [KO:K03006] [EC:2.7.7.6]
TbgDal_VIII7660  RNA polymerase IIA largest subunit, (fragment) [KO:K03006] [EC:2.7.7.6]
TbgDal_IV3880  DNA-directed RNA polymerase II subunit 2,putative [KO:K03010] [EC:2.7.7.6]
TbgDal_III6200  DNA-directed RNA polymerase II subunit 3,putative [KO:K03011]
TbgDal_X16090  DNA-directed RNA polymerases II subunit,putative [KO:K03013]
TbgDal_IV3500  DNA-directed RNA polymerase subunit, putative [KO:K03014]
TbgDal_IV3515  DNA-directed RNA polymerase subunit, putative [KO:K03014]
TbgDal_XI16230  RNA polymerase subunit, putative [KO:K03015]
TbgDal_XI9040  RNA polymerase B subunit RPB8, putative [KO:K03016]
TbgDal_XI8320  DNA-direcetd RNA polymerase II, subunit 9,putative [KO:K03017]
TbgDal_III1000  DNA-directed RNA polymerase subunit, putative [KO:K03007]
TbgDal_XI2400  DNA-directed RNA polymerase II, putative [KO:K03008]
TbgDal_III5740  DNA repair helicase and transcription factor protein, putative [KO:K10843] [EC:5.6.2.4]
TbgDal_XI18270  DNA repair helicase and transcription factor protein, putative [KO:K10843] [EC:5.6.2.4]
TbgDal_VIII5980  TFIIH basal transcription factor complex helicase subunit, putative [KO:K10844] [EC:5.6.2.3]
TbgDal_VIII6640  DNA repair and transcription factor protein,putative [KO:K03142]
TbgDal_X6340  hypothetical protein, conserved [KO:K03144]
TbgDal_IX7010  DNA repair protein RAD2, putative [KO:K10846]
TbgDal_XI10200  replication factor A, 51kDa subunit, putative [KO:K07466]
TbgDal_V2360  replication Factor A 28 kDa subunit, putative [KO:K10739]
TbgDal_V5120  DNA repair protein, putative [KO:K10848] [EC:3.1.-.-]
TbgDal_VII2240  DNA repair protein, putative [KO:K10849]
TbgDal_II350  DNA polymerase delta catalytic subunit, putative [KO:K02327] [EC:2.7.7.7]
TbgDal_III860  DNA polymerase delta subunit 2, putative [KO:K02328]
TbgDal_IX6060  DNA polymerase epsilon catalytic subunit,putative [KO:K02324] [EC:2.7.7.7]
TbgDal_IX9290  DNA polymerase epsilon subunit b, putative [KO:K02325] [EC:2.7.7.7]
TbgDal_IX2740  proliferative cell nuclear antigen (PCNA),putative [KO:K04802]
TbgDal_XI6370  replication factor C large subunit, putative [KO:K10754]
TbgDal_VI3670  replication factor C, subunit 2, putative [KO:K10755]
TbgDal_XI10720  replication factor C, subunit 4, putative [KO:K10755]
TbgDal_IX7480  replication factor C, subunit 3, putative [KO:K10756]
TbgDal_X9780  ATPase, putative [KO:K10756]
TbgDal_VI4610  DNA ligase I, putative [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
tbg03020  RNA polymerase
tbg04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (39)   
   KEGG GENES (39)   
All databases (40)   

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