KEGG   PATHWAY: tbg04141
Entry
tbg04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Trypanosoma brucei gambiense
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
tbg04141  Protein processing in endoplasmic reticulum
tbg04141

Other DBs
GO: 0030433 0034976
Organism
Trypanosoma brucei gambiense [GN:tbg]
Gene
TbgDal_XI7030  SEC61-like (pretranslocation process) protein,putative [KO:K10956]
TbgDal_III640  protein transport protein sec61 gamma subunit,putative [KO:K07342]
TbgDal_IX5780  chaperone protein DNAj, putative [KO:K09540]
TbgDal_V1270  oligosaccharyl transferase subunit, putative [KO:K07151] [EC:2.4.99.18]
TbgDal_V6580  oligosaccharyl transferase subunit, putative,(fragment) [KO:K07151] [EC:2.4.99.18]
TbgDal_XI8650  glucose-regulated protein 78, putative [KO:K09490] [EC:3.6.4.10]
TbgDal_XI8690  glucose-regulated protein 78, putative [KO:K09490] [EC:3.6.4.10]
TbgDal_VII4040  TPR-repeat-containing chaperone protein DNAJ,putative [KO:K09523]
TbgDal_X16730  glucosidase, putative [KO:K05546] [EC:3.2.1.207]
TbgDal_VII890  glucosidase II beta subunit, putative [KO:K08288]
TbgDal_IV5200  calreticulin, putative [KO:K08057]
TbgDal_XI4790  lectin, putative [KO:K10080]
TbgDal_V6040  ADP-ribosylation factor, putative [KO:K07953] [EC:3.6.5.-]
TbgDal_X16570  protein transport protein Sec13, putative [KO:K14004]
TbgDal_XI6960  protein transport protein sec31, putative [KO:K14005]
TbgDal_X9490  protein transport protein Sec23A, putative [KO:K14006]
TbgDal_III950  protein transport protein Sec24C, putative [KO:K14007]
TbgDal_III5150  UDP-glucose:glycoprotein glucosyltransferase,putative [KO:K11718] [EC:2.4.1.-]
TbgDal_IV2410  thioredoxin, putative [KO:K09584] [EC:5.3.4.1]
TbgDal_VII1260  protein disulfide isomerase, putative [KO:K09584] [EC:5.3.4.1]
TbgDal_XI11990  hypothetical protein, conserved [KO:K10088]
TbgDal_VII2440  hypothetical protein, conserved [KO:K13249]
TbgDal_XI14050  hypothetical protein, conserved [KO:K13989]
TbgDal_VII2520  hypothetical protein, conserved [KO:K14012]
TbgDal_X7000  Transitional endoplasmic reticulum ATPase,putative [KO:K13525]
TbgDal_III1030  hypothetical protein, conserved [KO:K14015]
TbgDal_X9550  ubiquitin fusion degradation protein, putative [KO:K14016]
TbgDal_VII640  heat shock 70 kDa protein, putative [KO:K03283]
TbgDal_XI12620  heat shock protein 70, putative [KO:K03283]
TbgDal_XI12660  heat shock protein 70, (fragment) [KO:K03283]
TbgDal_II3190  chaperone protein DNAj, putative [KO:K09503]
TbgDal_X2780  chaperone protein DNAj, putative [KO:K09503]
TbgDal_X8080  chaperone protein DNAj, putative [KO:K09518]
TbgDal_X13260  Heat shock protein 83, putative [KO:K04079]
TbgDal_X13270  Heat shock protein 83, putative [KO:K04079]
TbgDal_X13280  heat shock protein [KO:K04079]
TbgDal_III3490  heat shock protein 20, putative [KO:K13993]
TbgDal_X10680  hypothetical protein, conserved [KO:K13719] [EC:3.1.2.-]
TbgDal_VIII6390  hypothetical protein, conserved [KO:K14018]
TbgDal_VI4470  UV excision repair RAD23 protein, putative [KO:K10839]
TbgDal_X6030  ubiquitin-like protein DSK2, putative [KO:K04523]
TbgDal_III2970  elongation initiation factor 2 alpha subunit,putative [KO:K03237]
TbgDal_IV3220  ubiquitin carrier protein, putative [KO:K04554] [EC:2.3.2.23]
TbgDal_IV3470  ubiquitin carrier protein, putative [KO:K04554] [EC:2.3.2.23]
TbgDal_IX2790  hypothetical protein, conserved [KO:K10601] [EC:2.3.2.27]
TbgDal_IV2690  ubiquitin carrier protein, putative [KO:K06689] [EC:2.3.2.23]
TbgDal_V1360  ubiquitin carrier protein, putative [KO:K06689] [EC:2.3.2.23]
TbgDal_V5200  hypothetical protein, conserved [KO:K03868] [EC:2.3.2.32]
TbgDal_X2190  hypothetical protein, conserved [KO:K03868] [EC:2.3.2.32]
TbgDal_X9640  hypothetical protein, unlikely [KO:K03868] [EC:2.3.2.32]
TbgDal_XI6910  Cyclin A/CDK2-associated protein [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
tbg00510  N-Glycan biosynthesis
tbg03050  Proteasome
tbg03060  Protein export
KO pathway
ko04141   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (51)   
   KEGG GENES (51)   
All databases (52)   

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