KEGG   PATHWAY: tbr00230
Entry
tbr00230                    Pathway                                
Name
Purine metabolism - Trypanosoma brucei brucei
Class
Metabolism; Nucleotide metabolism
Pathway map
tbr00230  Purine metabolism
tbr00230

Module
tbr_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:tbr00230]
tbr_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:tbr00230]
tbr_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:tbr00230]
tbr_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:tbr00230]
Other DBs
GO: 0006163 0042278
Organism
Trypanosoma brucei brucei [GN:tbr]
Gene
Tb11.01.1570  NUDIX hydrolase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
Tb10.6k15.0970  phosphoribosylpyrophosphate synthetase, putative [KO:K00948] [EC:2.7.6.1]
Tb927.5.2960  phosphoribosylpyrophosphate synthetase, putative [KO:K00948] [EC:2.7.6.1]
Tb927.5.3170  ribose-phosphate pyrophosphokinase, putative [KO:K00948] [EC:2.7.6.1]
Tb11.02.0530  phosphoribosylpyrophosphate synthetase, putative [KO:K00948] [EC:2.7.6.1]
Tb09.160.5560  adenylosuccinate lyase, putative [KO:K01756] [EC:4.3.2.2]
Tb927.7.1780  adenine phosphoribosyltransferase, putative [KO:K00759] [EC:2.4.2.7]
Tb927.7.1790  adenine phosphoribosyltransferase, putative [KO:K00759] [EC:2.4.2.7]
Tb927.3.2960  inosine-adenosine-guanosine-nucleoside hydrolase [KO:K01239] [EC:3.2.2.1]
Tb10.70.6650  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
Tb10.70.6540  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
Tb10.61.0150  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
Tb927.4.1720  nucleoside diphosphate kinase, putative [KO:K00940] [EC:2.7.4.6]
Tb11.01.7800  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
Tb09.211.2560  nucleoside diphosphate kinase, putative [KO:K00940] [EC:2.7.4.6]
Tb927.7.1930  nucleoside diphosphatase, putative [KO:K01511] [EC:3.6.1.6]
Tb10.6k15.0290  hypothetical protein, conserved [KO:K01519] [EC:3.6.1.66]
Tb927.7.2100  GMP synthase, putative [KO:K01951] [EC:6.3.5.2]
Tb927.5.2080  inosine-5'-monophosphate dehydrogenase, putative [KO:K00364] [EC:1.7.1.7]
Tb927.5.4560  guanine deaminase, putative [KO:K01487] [EC:3.5.4.3]
Tb10.26.0200  guanylate kinase, putative [KO:K00942] [EC:2.7.4.8]
Tb10.6k15.3960  guanylate kinase, putative [KO:K00942] [EC:2.7.4.8]
Tb11.02.5720  ribonucleoside-diphosphate reductase large chain [KO:K10807] [EC:1.17.4.1]
Tb11.v4.0005  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Tb11.v4.0006  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Tb11.v4.0004  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Tb11.v4.0007  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Tb09.211.2190  hypothetical protein, conserved [KO:K07023] [EC:3.1.3.89]
Tb09.160.1950  acidocalcisomal exopolyphosphatase, putative [KO:K01514] [EC:3.6.1.11]
Tb11.01.8820  expression site-associated gene (ESAG) protein, putative [KO:K01768] [EC:4.6.1.1]
Tb927.8.8360  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.4.4410  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.8.7590  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.4.4430  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.4.4440  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.4.4450  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.4.4460  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.4.4470  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb10.61.0060  expression site-associated gene 4 (ESAG4) protein, putative [KO:K01768] [EC:4.6.1.1]
Tb927.8.7890  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.8.7900  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.8.7920  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.8.7930  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.8.7940  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.6.170  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.6.180  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.6.200  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.6.190  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.6.280  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.6.300  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.6.310  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.6.330  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb09.244.2380  expression site-associated protein [KO:K01768] [EC:4.6.1.1]
Tb927.7.7470  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.6.430  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb11.03.0990  expression site-associated gene 4 (ESAG4) protein, putative [KO:K01768] [EC:4.6.1.1]
Tb927.7.7520  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.7.7530  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.7.6040  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.7.6050  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.7.6060  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.7.6070  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb11.01.5310  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.7.6080  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb10.389.0430  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.6.760  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.6.770  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.6.780  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.6.790  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.6.800  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb11.27.0001  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.5.330  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.5.320  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb11.02.3740  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.5.650  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.4.3750  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb10.70.5260  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.4.3860  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.4.3870  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.4.3880  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.5.1450  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb10.61.0280  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.5.4540  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.5.4550  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.8.7860  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb927.8.7870  receptor-type adenylate cyclase GRESAG 4, putative [KO:K01768] [EC:4.6.1.1]
Tb10.389.0510  3' 5'-cyclic nucleotide phosphodiesterase [KO:K01120] [EC:3.1.4.17]
Tb11.02.1120  adenylosuccinate synthetase, putative [KO:K01939] [EC:6.3.4.4]
Tb09.211.1320  AMP deaminase, putative [KO:K01490] [EC:3.5.4.6]
Tb09.160.5250  adenosine monophosphate deaminase, putative [KO:K01490] [EC:3.5.4.6]
Tb11.01.7390  AMP deaminase, putative [KO:K01490] [EC:3.5.4.6]
Tb927.6.2300  adenosine kinase, putative [KO:K00856] [EC:2.7.1.20]
Tb927.6.2360  adenosine kinase, putative [KO:K00856] [EC:2.7.1.20]
Tb10.70.1200  adenylate kinase, putative [KO:K00939] [EC:2.7.4.3]
Tb927.2.5660  adenylate kinase, putative [KO:K00939] [EC:2.7.4.3]
Tb10.70.7330  adenylate kinase, putative [KO:K00939] [EC:2.7.4.3]
Tb09.211.0350  adenylate kinase, putative [KO:K00939] [EC:2.7.4.3]
Tb10.70.5150  adenylate kinase, putative [KO:K00939] [EC:2.7.4.3]
Tb927.5.3970  adenylate kinase, putative [KO:K00939] [EC:2.7.4.3]
Tb10.70.5130  adenylate kinase, putative [KO:K00939] [EC:2.7.4.3]
Tb927.6.3210  hypothetical protein, conserved [KO:K18532] [EC:2.7.4.3]
Tb927.3.3070  3', 5'-cyclic nucleotide phosphodiesterase, putative [KO:K13293] [EC:3.1.4.53]
Tb09.160.3630  cAMP-specific phosphodiesterase [KO:K13294] [EC:3.1.4.53]
Tb09.160.3590  cAMP-specific phosphodiesterase [KO:K13294] [EC:3.1.4.53]
Tb927.8.2980  Bis(5'-adenosyl)-triphosphatase, putative [KO:K01522] [EC:3.6.1.29]
Tb927.8.8040  diadenosine tetraphosphatase, putative [KO:K01525] [EC:3.6.1.41]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
tbr00030  Pentose phosphate pathway
tbr00220  Arginine biosynthesis
tbr00250  Alanine, aspartate and glutamate metabolism
tbr00260  Glycine, serine and threonine metabolism
tbr00340  Histidine metabolism
tbr00630  Glyoxylate and dicarboxylate metabolism
tbr00730  Thiamine metabolism
tbr00740  Riboflavin metabolism
tbr00790  Folate biosynthesis
KO pathway
ko00230   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (106)   
   KEGG GENES (106)   
All databases (107)   

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