KEGG   PATHWAY: tbr03013
Entry
tbr03013                    Pathway                                
Name
Nucleocytoplasmic transport - Trypanosoma brucei brucei
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
tbr03013  Nucleocytoplasmic transport
tbr03013

Other DBs
GO: 0050658
Organism
Trypanosoma brucei brucei [GN:tbr]
Gene
Tb09.160.2360  poly(A) export protein, putative [KO:K14298]
Tb11.03.0140  nucleoporin, putative [KO:K14297]
Tb927.2.2460  ubiquitin-conjugating enzyme E2, putative [KO:K10577]
Tb10.61.2630  protein transport protein Sec13, putative [KO:K14004]
Tb11.01.7200  hypothetical protein, conserved [KO:K14306]
Tb10.6k15.2350  nuclear pore complex protein NUP155 [KO:K14312]
Tb10.6k15.3670  nucleoporin interacting component NUP93 [KO:K14309]
Tb927.6.2640  importin alpha subunit, putative [KO:K15042]
Tb10.70.4720  importin subunit beta-1 [KO:K14293]
Tb09.211.4360  hypothetical protein, conserved [KO:K18727]
Tb11.01.8030  hypothetical protein, conserved [KO:K20221]
Tb11.01.7010  hypothetical protein, conserved [KO:K20222]
Tb11.02.1720  hypothetical protein, conserved [KO:K20223]
Tb927.3.4600  hypothetical protein, conserved [KO:K20223]
Tb11.01.5940  exportin 1 [KO:K14290]
Tb927.6.4740  importin-alpha re-exporter protein, putative [KO:K18423]
Tb927.2.2240  tRNA exportin, putative [KO:K14288]
Tb927.8.4660  hypothetical protein, conserved [KO:K18460]
Tb927.3.1120  GTP-binding nuclear protein rtb2, putative [KO:K07936]
Tb10.70.5650  elongation factor 1-alpha [KO:K03231]
Tb10.70.5670  elongation factor 1-alpha [KO:K03231]
Tb10.70.5680  elongation factor 1-alpha [KO:K03231]
Tb927.6.1970  nuclear cap binding protein, putative [KO:K12883]
Tb927.7.970  hypothetical protein, conserved [KO:K07562]
Tb927.7.1170  hypothetical protein, conserved [KO:K12876]
Tb927.6.4950  mago nashi-like protein,putative [KO:K12877]
Tb11.12.0011  ATP-dependent DEAD/H RNA helicase, putative [KO:K13025] [EC:5.6.2.7]
Tb927.5.2140  regulator of nonsense transcripts 1, putative [KO:K14326] [EC:5.6.2.5 5.6.2.3]
Tb11.22.0004  hypothetical protein, conserved [KO:K14284]
Tb927.7.5760  nuclear transport factor 2 protein, putative [KO:K14285]
Tb10.70.7730  ATP-dependent DEAD/H RNA helicase, putative [KO:K12812] [EC:5.6.2.7]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
tbr03015  mRNA surveillance pathway
KO pathway
ko03013   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG GENES (31)   
All databases (32)   

Download RDF
DBGET integrated database retrieval system