KEGG   PATHWAY: tco03440
Entry
tco03440                    Pathway                                
Name
Homologous recombination - Thermobacillus composti
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
tco03440  Homologous recombination
tco03440

Other DBs
GO: 0000724
Organism
Thermobacillus composti [GN:tco]
Gene
Theco_2507  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Theco_3780  single stranded DNA-binding protein [KO:K03111]
Theco_4119  single-stranded DNA-binding protein [KO:K03111]
Theco_3756  recF protein [KO:K03629]
Theco_2363  DNA repair protein RecO [KO:K03584]
Theco_3531  recombination protein RecR [KO:K06187]
Theco_2026  protein RecA [KO:K03553]
Theco_1331  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Theco_2520  Holliday junction DNA helicase, RuvA subunit [KO:K03550]
Theco_2519  Holliday junction DNA helicase, RuvB subunit [KO:K03551] [EC:5.6.2.4]
Theco_2521  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
Theco_2169  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Theco_2621  DNA-directed DNA polymerase III PolC [KO:K02337] [EC:2.7.7.7]
Theco_2062  DNA polymerase III, alpha chain [KO:K03763] [EC:2.7.7.7]
Theco_3758  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Theco_4107  DNA polymerase sliding clamp subunit [KO:K02338] [EC:2.7.7.7]
Theco_3533  DNA polymerase III, subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
Theco_2414  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Theco_3740  hypothetical protein [KO:K02341] [EC:2.7.7.7]
Theco_1495  DNA polymerase III epsilon subunit-like 3'-5' exonuclease [KO:K02342] [EC:2.7.7.7]
Theco_1436  exonuclease, DNA polymerase III, epsilon subunit family [KO:K02342] [EC:2.7.7.7]
Theco_2186  primosomal protein N'' [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG GENES (22)   
All databases (23)   

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