KEGG   PATHWAY: tcr03013
Entry
tcr03013                    Pathway                                
Name
Nucleocytoplasmic transport - Trypanosoma cruzi
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
tcr03013  Nucleocytoplasmic transport
tcr03013

Other DBs
GO: 0050658
Organism
Trypanosoma cruzi [GN:tcr]
Gene
511577.130  poly(A) export protein [KO:K14298]
508741.280  ubiquitin-conjugating enzyme E2 [KO:K10577]
503515.14  ubiquitin-conjugating enzyme E2 [KO:K10577]
511283.20  protein transport protein sec13 [KO:K14004]
506525.20  protein transport protein sec13 [KO:K14004]
506247.70  nuclear pore complex protein (NUP155) [KO:K14312]
510181.50  nucleoporin interacting component (NUP93) [KO:K14309]
509057.20  importin alpha [KO:K15042]
504105.150  importin beta-1 subunit [KO:K14293]
510655.90  hypothetical protein [KO:K18727]
511529.9  hypothetical protein [KO:K20221]
506425.40  hypothetical protein [KO:K20222]
506177.50  hypothetical protein [KO:K20223]
510329.170  hypothetical protein [KO:K20223]
511725.150  exportin 1 [KO:K14290]
506945.30  CAS/CSE/importin domain protein [KO:K18423]
509395.30  tRNA exportin [KO:K14288]
509573.50  hypothetical protein [KO:K18460]
503539.30  GTP-binding nuclear protein rtb2 [KO:K07936]
509455.80  GTP-binding nuclear protein rtb2 [KO:K07936]
511369.30  elongation factor 1-alpha (EF-1-alpha) [KO:K03231]
511369.5  elongation factor 1-alpha (EF-1-alpha) [KO:K03231]
511367.360  elongation factor 1-alpha (EF-1-alpha) [KO:K03231]
511367.370  elongation factor 1-alpha (EF-1-alpha) [KO:K03231]
510119.9  elongation factor 1-alpha (EF-1-alpha) [KO:K03231]
511369.10  elongation factor 1-alpha (EF-1-alpha) [KO:K03231]
511369.20  elongation factor 1-alpha (EF-1-alpha) [KO:K03231]
510119.20  elongation factor 1-alpha (EF-1-alpha) [KO:K03231]
504071.80  nuclear cap binding protein [KO:K12883]
503843.10  hypothetical protein [KO:K07562]
506729.90  hypothetical protein [KO:K07562]
507515.40  hypothetical protein [KO:K12876]
508213.40  hypothetical protein [KO:K12876]
506945.200  mago nashi-like protein [KO:K12877]
506587.40  ATP-dependent DEAD/H RNA helicase [KO:K13025] [EC:5.6.2.7]
511199.9  ATP-dependent DEAD/H RNA helicase [KO:K13025] [EC:5.6.2.7]
511317.30  regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
506297.40  hypothetical protein [KO:K14327]
506127.20  hypothetical protein [KO:K14284]
508173.180  nuclear transport factor 2 protein(NFT2) [KO:K14285]
508319.40  RNA helicase [KO:K12812] [EC:5.6.2.7]
482471.19  ATP-dependent DEAD/H RNA helicase [KO:K12812] [EC:5.6.2.7]
511139.40  RNA helicase [KO:K12812] [EC:5.6.2.7]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
tcr03015  mRNA surveillance pathway
KO pathway
ko03013   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (43)   
   KEGG GENES (43)   
All databases (44)   

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