KEGG   PATHWAY: tcr04141
Entry
tcr04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Trypanosoma cruzi
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
tcr04141  Protein processing in endoplasmic reticulum
tcr04141

Other DBs
GO: 0030433 0034976
Organism
Trypanosoma cruzi [GN:tcr]
Gene
506297.240  pretranslocation protein, alpha subunit [KO:K10956]
510101.70  pretranslocation protein, alpha subunit [KO:K10956]
511865.54  protein transport protein Sec61 gamma subunit [KO:K07342]
511871.34  protein transport protein Sec61 gamma subunit [KO:K07342]
506887.90  hypothetical protein [KO:K09540]
510731.80  hypothetical protein [KO:K09540]
505163.80  oligosaccharyl transferase subunit [KO:K07151] [EC:2.4.99.18]
511015.10  mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
510895.9  hypothetical protein [KO:K01228] [EC:3.2.1.106]
511805.10  mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
509201.10  hypothetical protein [KO:K01228] [EC:3.2.1.106]
506585.40  glucose-regulated protein 78 [KO:K09490] [EC:3.6.4.10]
510407.80  hypothetical protein [KO:K09523]
509937.160  hypothetical protein [KO:K09523]
507993.260  hypothetical protein [KO:K05546] [EC:3.2.1.207]
511279.60  hypothetical protein [KO:K05546] [EC:3.2.1.207]
508215.9  protein kinase C substrate protein, heavy chain [KO:K08288]
509011.40  calreticulin [KO:K08057]
510685.10  calreticulin [KO:K08057]
506177.20  lectin [KO:K10080]
509539.50  small GTP-binding protein [KO:K07953] [EC:3.6.5.-]
419417.4  ADP-ribosylation factor [KO:K07953] [EC:3.6.5.-]
511283.20  protein transport protein sec13 [KO:K14004]
506525.20  protein transport protein sec13 [KO:K14004]
506297.290  protein transport protein sec31 [KO:K14005]
506249.20  protein transport protein Sec23A [KO:K14006]
509453.70  protein transport protein Sec24C [KO:K14007]
510329.130  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
508317.80  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [KO:K10085]
508209.140  protein disulfide isomerase [KO:K09584] [EC:5.3.4.1]
506559.200  thioredoxin [KO:K09584] [EC:5.3.4.1]
506155.99  hypothetical protein [KO:K10088]
511807.250  hypothetical protein [KO:K13249]
509029.110  hypothetical protein [KO:K13989]
510431.100  hypothetical protein [KO:K13989]
511807.290  hypothetical protein [KO:K14012]
509733.170  transitional endoplasmic reticulum ATPase [KO:K13525]
506709.30  hypothetical protein [KO:K14015]
504167.40  ubiquitin fusion degradation protein [KO:K14016]
511211.160  heat shock protein 70 (HSP70) [KO:K03283]
511211.170  heat shock protein 70 (HSP70) [KO:K03283]
511211.220  heat shock protein 70 [KO:K03283]
511367.138  chaperone DnaJ protein [KO:K09503]
511627.110  heat shock protein DnaJ [KO:K09503]
510187.330  hypothetical protein [KO:K09518]
509105.140  heat shock protein 85 [KO:K04079]
509643.130  heat shock protein 85 [KO:K04079]
507713.30  heat shock protein 85 [KO:K04079]
510323.40  heat shock protein 20 [KO:K13993]
508153.270  heat shock protein 20 [KO:K13993]
508723.59  hypothetical protein [KO:K13719] [EC:3.1.2.-]
511903.290  hypothetical protein [KO:K14018]
503885.90  hypothetical protein [KO:K14018]
506833.60  UV excision repair RAD23-like protein [KO:K10839]
511731.10  UV excision repair RAD23-like protein [KO:K10839]
506583.30  ubiquitin-like protein [KO:K04523]
506677.10  ubiquitin-like protein [KO:K04523]
508153.730  elongation initiation factor 2 alpha subunit [KO:K03237]
504055.81  ubiquitin-conjugating enzyme E2 [KO:K04554] [EC:2.3.2.23]
506435.300  ubiquitin-conjugating enzyme E2 [KO:K04554] [EC:2.3.2.23]
508277.190  hypothetical protein [KO:K10601] [EC:2.3.2.27]
509945.10  hypothetical protein [KO:K10601] [EC:2.3.2.27]
511179.160  ubiquitin-conjugating enzyme E2 [KO:K06689] [EC:2.3.2.23]
508303.4  ubiquitin-conjugating enzyme E2 [KO:K06689] [EC:2.3.2.23]
508029.20  ubiquitin-conjugating enzyme E2 [KO:K06689] [EC:2.3.2.23]
503965.20  hypothetical protein [KO:K03868] [EC:2.3.2.32]
506495.9  hypothetical protein [KO:K03868] [EC:2.3.2.32]
506297.350  S-phase kinase-associated protein [KO:K03094]
508041.10  S-phase kinase-associated protein [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
tcr00510  N-Glycan biosynthesis
tcr03050  Proteasome
tcr03060  Protein export
KO pathway
ko04141   

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Genome (1)   
   KEGG GENOME (1)   
Gene (69)   
   KEGG GENES (69)   
All databases (70)   

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