KEGG   PATHWAY: tgo03013
Entry
tgo03013                    Pathway                                
Name
Nucleocytoplasmic transport - Toxoplasma gondii
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
tgo03013  Nucleocytoplasmic transport
tgo03013

Other DBs
GO: 0050658
Organism
Toxoplasma gondii [GN:tgo]
Gene
TGME49_259172  hypothetical protein [KO:K18723]
TGME49_220860  DEAD/DEAH box helicase [KO:K18655] [EC:5.6.2.7]
TGME49_272350  mRNA export protein [KO:K14298]
TGME49_259640  nucleoporin autopeptidase [KO:K14297]
TGME49_306560  hypothetical protein [KO:K14297]
TGME49_208780  ubiquitin-conjugating enzyme subfamily protein [KO:K10577]
TGME49_201700  WD domain, G-beta repeat-containing protein [KO:K14004]
TGME49_273850  hypothetical protein [KO:K14306]
TGME49_270270  hypothetical protein [KO:K20724]
TGME49_252290  importin alpha, putative [KO:K15042]
TGME49_295040  HEAT repeat-containing protein [KO:K14293]
TGME49_231600  HEAT repeat-containing protein [KO:K20221]
TGME49_229180  HEAT repeat-containing protein [KO:K20222]
TGME49_305040  HEAT repeat-containing protein [KO:K20222]
TGME49_223540  importin-beta N-terminal domain-containing protein [KO:K20223]
TGME49_249530  exportin 1, putative [KO:K14290]
TGME49_253730  importin-beta N-terminal domain-containing protein [KO:K18423]
TGME49_222380  importin-beta N-terminal domain-containing protein [KO:K18460]
TGME49_248340  GTP-binding nuclear protein ran/tc4 [KO:K07936]
TGME49_286420  elongation factor 1-alpha (EF-1-ALPHA), putative [KO:K03231]
TGME49_294800  elongation factor 1-alpha (EF-1-ALPHA), putative [KO:K03231]
TGME49_249610  hypothetical protein [KO:K12882]
TGME49_289560  RNA recognition motif-containing protein [KO:K12883]
TGME49_216480  NMD3 family protein [KO:K07562]
TGME49_233230  RNA-binding protein 8A family protein [KO:K12876]
TGME49_267420  mago nashi family protein 2, putative [KO:K12877]
TGME49_256770  eukaryotic translation initiation factor 4A, isoform 3, putative [KO:K13025] [EC:5.6.2.7]
TGME49_291330  RNA recognition motif-containing protein [KO:K12881]
TGME49_291820  RNA helicase (UPF2 interacting domain) protein [KO:K14326] [EC:5.6.2.5 5.6.2.3]
TGME49_246040  MIF4G domain-containing protein [KO:K14327]
TGME49_315720  Smg-4/UPF3 family protein [KO:K14328]
TGME49_216860  DDX39; DEAD (Asp-Glu-Ala-Asp) box polypeptide DDX39 [KO:K12812] [EC:5.6.2.7]
TGME49_311160  PWI domain-containing protein [KO:K13171]
TGME49_311750  mago binding protein [KO:K14294]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
tgo03015  mRNA surveillance pathway
KO pathway
ko03013   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (34)   
   KEGG GENES (34)   
All databases (35)   

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