KEGG   PATHWAY: tgo03420
Entry
tgo03420                    Pathway                                
Name
Nucleotide excision repair - Toxoplasma gondii
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
tgo03420  Nucleotide excision repair
tgo03420

Other DBs
GO: 0006289
Organism
Toxoplasma gondii [GN:tgo]
Gene
TGME49_213690  ring box protein 1 family protein [KO:K03868] [EC:2.3.2.32]
TGME49_316660  cullin family protein [KO:K10609]
TGME49_295340  UV excision repair protein Rad23 protein [KO:K10839]
TGME49_263140  RAD26; SWI2/SNF2-containing protein RAD26 [KO:K10841]
TGME49_225260  POLR2A; DNA-directed RNA polymerase II RPB1 [KO:K03006] [EC:2.7.7.6]
TGME49_258210  DNA-directed RNA polymerase II RPB2 [KO:K03010] [EC:2.7.7.6]
TGME49_238190  POLR2C; DNA-directed RNA polymerase II RPB3 [KO:K03011]
TGME49_231380  POLR2D; DNA-directed RNA polymerase II RPB4 [KO:K03012]
TGME49_240590  POLR2E; DNA-directed RNA polymerase II RPB5 [KO:K03013]
TGME49_270780  POLR2F; DNA-directed RNA polymerase II RPB6 [KO:K03014]
TGME49_271300  POLR2G; DNA-directed RNA polymerase II RPB7 [KO:K03015]
TGME49_233720  POLR2H; DNA-directed RNA polymerase II RPBABC8 [KO:K03016]
TGME49_202690  POLR2I; DNA-directed RNA polymerase II RPB9 [KO:K03017]
TGME49_217560  POLR2L; DNA-directed RNA polymerase II RPB10 [KO:K03007]
TGME49_254140  POLR2K; DNA-directed RNA polymerase II RPABC4 [KO:K03009]
TGME49_315920  POLR2J; DNA-directed RNA polymerase II RPB11A [KO:K03008]
TGME49_270330  cell-cycle-associated protein kinase, putative [KO:K02202] [EC:2.7.11.22 2.7.11.23]
TGME49_320070  CDK-activating kinase assembly factor MAT1 protein [KO:K10842]
TGME49_269660  TFIIH basal transcription factor complex helicase XPB subunit [KO:K10843] [EC:5.6.2.4]
TGME49_216870  DNA excision repair helicase [KO:K10844] [EC:5.6.2.3]
TGME49_217450  GTF2H5; general transcription factor IIH polypeptide 5 GTF2H5 [KO:K10845]
TGME49_294920  GTF2H2; general transcription factor IIH polypeptide 2 GTF2H2 [KO:K03142]
TGME49_266930  GTF2H3; general transcription factor IIH polypeptide 3 GTF2H3 [KO:K03143]
TGME49_214520  GTF2H4; general transcription factor IIH polypeptide 4 GTF2H4 [KO:K03144]
TGME49_268560  XPG N-terminal domain-containing protein [KO:K10846]
TGME49_236080  replication factor-a protein 1 (rpa1) subfamily protein [KO:K07466]
TGME49_253080  hypothetical protein [KO:K10739]
TGME49_238110  replication factor a protein 3 protein [KO:K10740]
TGME49_249330  DNA repair protein rad10 subfamily protein [KO:K10849]
TGME49_258030  DNA polymerase [KO:K02327] [EC:2.7.7.7]
TGME49_233820  DNA polymerase epsilon subunit B protein [KO:K02328]
TGME49_254640  hypothetical protein [KO:K03505]
TGME49_319860  DNA polymerase family B protein [KO:K02324] [EC:2.7.7.7]
TGME49_280690  DNA polymerase epsilon subunit B protein [KO:K02325] [EC:2.7.7.7]
TGME49_320110  PCNA2; proliferating cell nuclear antigen PCNA2 [KO:K04802]
TGME49_247460  PCNA1; proliferating cell nuclear antigen PCNA1 [KO:K04802]
TGME49_235170  ATPase, AAA family protein [KO:K10754]
TGME49_237110  replication factor C subunit 2, putative [KO:K10755]
TGME49_210960  replication factor C subunit 4, putative [KO:K10755]
TGME49_273950  replication factor C subunit 5, putative [KO:K10756]
TGME49_213000  replication factor C, subunit 5, putative [KO:K10756]
TGME49_208580  DNA ligase 1, putative [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
tgo03020  RNA polymerase
tgo04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (42)   
   KEGG GENES (42)   
All databases (43)   

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