KEGG   PATHWAY: tgo04141
Entry
tgo04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Toxoplasma gondii
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
tgo04141  Protein processing in endoplasmic reticulum
tgo04141

Other DBs
GO: 0030433 0034976
Organism
Toxoplasma gondii [GN:tgo]
Gene
TGME49_269980  preprotein translocase Sec61, putative [KO:K10956]
TGME49_211040  Sec61beta family protein [KO:K09481]
TGME49_230380  protein translocation complex, SEC61 gamma subunit [KO:K07342]
TGME49_293570  translocation protein sec62, putative [KO:K12275]
TGME49_260630  DnaJ family Sec63 protein [KO:K09540]
TGME49_202572  ribophorin I protein [KO:K12666]
TGME49_305870  DAD family protein [KO:K12668]
TGME49_203970  dolichyl-diphosphooligosaccharide--protein glycosyltransferase [KO:K12670]
TGME49_231430  oligosaccharyl transferase stt3 protein, putative [KO:K07151] [EC:2.4.99.18]
TGME49_242020  mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
TGME49_226830  DnaK family protein [KO:K09486]
TGME49_311720  chaperonin protein BiP [KO:K09490] [EC:3.6.4.10]
TGME49_244560  heat shock protein 90, putative [KO:K09487]
TGME49_253030  glycosyl hydrolase, family 31 protein [KO:K05546] [EC:3.2.1.207]
TGME49_310320  calreticulin family protein [KO:K08054]
TGME49_215060  small GTP-binding protein sar1, putative [KO:K07953] [EC:3.6.5.-]
TGME49_201700  WD domain, G-beta repeat-containing protein [KO:K14004]
TGME49_311400  WD domain, G-beta repeat-containing protein [KO:K14005]
TGME49_291680  Sec23/Sec24 trunk domain-containing protein [KO:K14006]
TGME49_226510  Sec23/Sec24 trunk domain-containing protein [KO:K14007]
TGME49_277000  transport protein Sec24, putative [KO:K14007]
TGME49_211680  protein disulfide isomerase [KO:K09580] [EC:5.3.4.1]
TGME49_224060  thioredoxin, putative [KO:K09580] [EC:5.3.4.1]
TGME49_218470  protein disulfide-isomerase, putative [KO:K09582] [EC:5.3.4.1]
TGME49_249270  protein disulfide isomerase-related protein (provisional), putative [KO:K09584] [EC:5.3.4.1]
TGME49_300380  endoplasmic reticulum oxidoreductin, putative [KO:K10950] [EC:1.8.4.-]
TGME49_294290  Der1ER1 [KO:K13989]
TGME49_217160  Der1 family protein [KO:K13989]
TGME49_220500  UBX domain-containing protein [KO:K14012]
TGME49_273090  CDC48CY; cell division protein CDC48CY [KO:K13525]
TGME49_271440  NPL4 family protein [KO:K14015]
TGME49_270530  UFD1CY; ubiquitin fusion degradation protein UFD1CY [KO:K14016]
TGME49_285700  UFD1AP; ubiquitin fusion degradation protein UFD1AP [KO:K14016]
TGME49_273760  HSP70; heat shock protein HSP70 [KO:K03283]
TGME49_311240  DnaJ family chaperone, putative [KO:K09503]
TGME49_259980  DnaJ domain-containing protein [KO:K09518]
TGME49_288380  HSP90; heat shock protein HSP90 [KO:K04079]
TGME49_286720  HSP28; heat shock protein HSP28 [KO:K13993]
TGME49_259020  BAG1; bradyzoite antigen BAG1 [KO:K13993]
TGME49_232940  HSP20; heat shock protein HSP20 [KO:K13993]
TGME49_277990  OTU family cysteine protease [KO:K13719] [EC:3.1.2.-]
TGME49_288210  PUL domain-containing protein [KO:K14018]
TGME49_295340  UV excision repair protein Rad23 protein [KO:K10839]
TGME49_223680  ubiquitin family protein [KO:K04523]
TGME49_240700  ubiquitin family protein [KO:K04523]
TGME49_229650  josephin protein [KO:K11863] [EC:3.4.22.-]
TGME49_313230  eukaryotic initiation factor-2, alpha subunit [KO:K03237]
TGME49_278670  ubiquitin-conjugating enzyme subfamily protein [KO:K10578] [EC:2.3.2.23]
TGME49_251640  ubiquitin-conjugating enzyme subfamily protein [KO:K04554] [EC:2.3.2.23]
TGME49_202820  ubiquitin-conjugating enzyme subfamily protein [KO:K10575] [EC:2.3.2.23]
TGME49_304460  zinc finger, C3HC4 type (RING finger) domain-containing protein [KO:K10601] [EC:2.3.2.27]
TGME49_265380  tetratricopeptide repeat (TPR)-/U-box domain-containing protein [KO:K09561] [EC:2.3.2.27]
TGME49_319870  ubiquitin-conjugating enzyme subfamily protein [KO:K06689] [EC:2.3.2.23]
TGME49_213690  ring box protein 1 family protein [KO:K03868] [EC:2.3.2.32]
TGME49_289310  cullin family protein [KO:K03347]
TGME49_207680  suppressor of kinetochore protein 1, putative [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
tgo00510  N-Glycan biosynthesis
tgo03050  Proteasome
tgo03060  Protein export
KO pathway
ko04141   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (56)   
   KEGG GENES (56)   
All databases (57)   

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