KEGG   PATHWAY: tpv03013
Entry
tpv03013                    Pathway                                
Name
Nucleocytoplasmic transport - Theileria parva
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
tpv03013  Nucleocytoplasmic transport
tpv03013

Other DBs
GO: 0050658
Organism
Theileria parva [GN:tpv]
Gene
TP01_0055  DEAD box RNA helicase [KO:K18655] [EC:5.6.2.7]
TP01_0140  mRNA export protein [KO:K14298]
TP04_0735  hypothetical protein [KO:K14297]
TP02_0318  hypothetical protein [KO:K14297]
TP03_0540  ubiquitin-conjugating enzyme [KO:K10577]
TP03_0168  hypothetical protein [KO:K14314]
TP02_0699  hypothetical protein [KO:K20724]
TP04_0908  importin alpha [KO:K15042]
TP01_0072  importin beta [KO:K14293]
TP04_0218  transportin [KO:K18752]
TP02_0572  hypothetical protein [KO:K15436]
TP01_0283  karyopherin beta [KO:K20222]
TP02_0231  hypothetical protein [KO:K20223]
TP01_1142  hypothetical protein [KO:K13151]
TP02_0177  importin beta-related nuclear transport factor [KO:K14290]
TP04_0541  hypothetical protein [KO:K18423]
TP04_0363  hypothetical protein [KO:K18460]
TP01_0757  GTP-binding nuclear protein ran [KO:K07936]
TP01_0726  elongation factor 1 alpha [KO:K03231]
TP01_0430  hypothetical protein [KO:K12882]
TP01_0963  nuclear cap-binding protein [KO:K12883]
TP01_0828  hypothetical protein [KO:K07562]
TP04_0225  mago nashi protein [KO:K12877]
TP01_0765  eukaryotic translation initiation factor 4A [KO:K13025] [EC:5.6.2.7]
TP02_0067  hypothetical protein [KO:K12881]
TP03_0373  ATP-dependent RNA helicase [KO:K12812] [EC:5.6.2.7]
TP02_0366  hypothetical protein [KO:K13171]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
tpv03015  mRNA surveillance pathway
KO pathway
ko03013   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG GENES (27)   
All databases (28)   

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