KEGG   PATHWAY: tva03013
Entry
tva03013                    Pathway                                
Name
Nucleocytoplasmic transport - Trichomonas vaginalis
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
tva03013  Nucleocytoplasmic transport
tva03013

Other DBs
GO: 0050658
Organism
Trichomonas vaginalis [GN:tva]
Gene
TVAG_2v0213440  helicase [KO:K18655] [EC:5.6.2.7]
TVAG_2v0283960  helicase [KO:K18655] [EC:5.6.2.7]
TVAG_2v0089940  transcription-dependent tethering of RNA polymerase II gene DNA protein [KO:K14298]
TVAG_2v0932020  transcription-dependent tethering of RNA polymerase II gene DNA protein [KO:K14298]
TVAG_2v0563160  transcription-dependent tethering of RNA polymerase II gene DNA protein [KO:K14298]
TVAG_2v0389630  ubiquitin-conjugating enzyme family [KO:K10577]
TVAG_2v0904260  positive regulation of TORC1 signaling [KO:K14004]
TVAG_2v0263770  positive regulation of TORC1 signaling [KO:K14004]
TVAG_2v0393780  structural constituent of nuclear pore [KO:K14306]
TVAG_2v0166190  protein localization to nuclear inner membrane [KO:K14308]
TVAG_2v0694880  protein localization to nuclear inner membrane [KO:K14308]
TVAG_2v0526850  nuclear pore organization [KO:K14310]
TVAG_2v0398170  nuclear pore complex protein NUP155 family [KO:K14312]
TVAG_2v1018100  nuclear pore complex protein NUP155 family [KO:K14312]
TVAG_2v1051790  nuclear pore complex protein NUP155 family [KO:K14312]
TVAG_2v0956270  nuclear pore complex assembly [KO:K14309]
TVAG_2v0245260  nuclear pore complex assembly [KO:K14309]
TVAG_2v0979180  nuclear pore membrane glycoprotein GP210-related family [KO:K14314]
TVAG_2v0288870  nuclear pore membrane glycoprotein GP210-related family [KO:K14314]
TVAG_2v0772670  nuclear import signal receptor protein [KO:K23583]
TVAG_2v0001010  nuclear import signal receptor protein [KO:K23583]
TVAG_2v0965410  nuclear import signal receptor protein [KO:K23583]
TVAG_2v0373770  nuclear import signal receptor protein [KO:K23583]
TVAG_2v0007670  nuclear import signal receptor protein [KO:K23583]
TVAG_2v0234830  importin alpha family [KO:K15042]
TVAG_2v0289890  nuclear import signal receptor protein [KO:K15042]
TVAG_2v0470790  nuclear import signal receptor protein [KO:K15042]
TVAG_2v0265580  nuclear import signal receptor protein [KO:K15042]
TVAG_2v0000950  ribosomal protein import into nucleus [KO:K14293]
TVAG_2v0689970  ribosomal protein import into nucleus [KO:K14293]
TVAG_2v0579560  armadillo (ARM) repeat-containing protein family [KO:K20221]
TVAG_2v0889900  armadillo (ARM) repeat-containing protein family [KO:K20221]
TVAG_2v0881720  armadillo (ARM) repeat-containing protein family [KO:K20221]
TVAG_2v0420460  importin beta family [KO:K20221]
TVAG_2v0673270  armadillo (ARM) repeat-containing protein family [KO:K20221]
TVAG_2v0947090  importin beta family [KO:K20221]
TVAG_2v0232310  importin beta family [KO:K20221]
TVAG_2v0529140  importin beta family [KO:K20221]
TVAG_2v0971580  importin beta family [KO:K20221]
TVAG_2v0826240  armadillo (ARM) repeat-containing protein family [KO:K20221]
TVAG_2v0228500  importin beta family [KO:K20222]
TVAG_2v0848470  importin beta family [KO:K20222]
TVAG_2v0060760  armadillo (ARM) repeat-containing protein family [KO:K20222]
TVAG_2v0962560  armadillo (ARM) repeat-containing protein family [KO:K20222]
TVAG_2v0826300  ribosomal protein import into nucleus [KO:K20222]
TVAG_2v0585720  armadillo (ARM) repeat-containing protein family [KO:K20223]
TVAG_2v0246930  armadillo (ARM) repeat-containing protein family [KO:K20223]
TVAG_2v1031900  armadillo (ARM) repeat-containing protein family [KO:K20223]
TVAG_2v0272500  hypothetical protein [KO:K20224]
TVAG_2v0925310  nuclear export signal receptor protein [KO:K14290]
TVAG_2v0273320  nuclear export signal receptor protein [KO:K14290]
TVAG_2v0316310  nuclear export signal receptor protein [KO:K18423]
TVAG_2v0974810  exportin 4,7-related family [KO:K18460]
TVAG_2v0939150  nuclear export signal receptor protein [KO:K18460]
TVAG_2v0694980  nuclear export signal receptor protein [KO:K18460]
TVAG_2v0580930  nuclear export signal receptor protein [KO:K18460]
TVAG_2v0878010  nuclear export signal receptor protein [KO:K18460]
TVAG_2v0529640  exportin 4,7-related family [KO:K18460]
TVAG_2v1037150  ribosome localization [KO:K07936]
TVAG_2v0393320  ribosome localization [KO:K07936]
TVAG_2v1048880  elongation factor 1-alpha 1 family [KO:K03231]
TVAG_2v0079960  elongation factor 1-alpha 1 family [KO:K03231]
TVAG_2v0427720  elongation factor 1-alpha 1 family [KO:K03231]
TVAG_2v0987120  elongation factor 1-alpha 1 family [KO:K03231]
TVAG_2v0955660  pre-mRNA 5' cap binding protein family [KO:K12882]
TVAG_2v0120600  RNA cap binding [KO:K12883]
TVAG_2v0579570  nonsense-mediated mRNA decay protein 3 family [KO:K07562]
TVAG_2v0369500  ribosomal large subunit binding [KO:K07562]
TVAG_2v0577480  nonsense-mediated mRNA decay protein 3 family [KO:K07562]
TVAG_2v0616030  helicase protein [KO:K13025] [EC:5.6.2.7]
TVAG_2v0175780  negative regulation of mRNA splicing, via spliceosome [KO:K14324]
TVAG_2v0552350  DNA2/NAM7 helicase family [KO:K14326] [EC:5.6.2.5 5.6.2.3]
TVAG_2v0948650  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [KO:K14327]
TVAG_2v0005540  NTF2-like family [KO:K14285]
TVAG_2v1002400  ATP-dependent RNA helicase DBP3 family [KO:K12812] [EC:5.6.2.7]
TVAG_2v0232710  mRNA transport [KO:K12879]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
tva03015  mRNA surveillance pathway
KO pathway
ko03013   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (76)   
   KEGG GENES (76)   
All databases (77)   

Download RDF
DBGET integrated database retrieval system