KEGG   PATHWAY: tva03040
Entry
tva03040                    Pathway                                
Name
Spliceosome - Trichomonas vaginalis
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
tva03040  Spliceosome
tva03040

Other DBs
GO: 0005681
Organism
Trichomonas vaginalis [GN:tva]
Gene
TVAG_2v0576870  RNA helicase family [KO:K12811] [EC:5.6.2.7]
TVAG_2v1002400  ATP-dependent RNA helicase DBP3 family [KO:K12812] [EC:5.6.2.7]
TVAG_2v0937220  ATP-dependent RNA helicase family [KO:K12813] [EC:5.6.2.6]
TVAG_2v0546320  ATP-dependent RNA helicase family [KO:K12815] [EC:5.6.2.6]
TVAG_2v0343440  mRNA splicing, via spliceosome [KO:K12816]
TVAG_2v0998030  nuclear retention of unspliced pre-mRNA at the site of transcription [KO:K12817]
TVAG_2v0105790  nuclear retention of unspliced pre-mRNA at the site of transcription [KO:K12817]
TVAG_2v0992380  ATP-dependent RNA helicase family [KO:K12818] [EC:5.6.2.6]
TVAG_2v0414600  ATP-dependent RNA helicase family [KO:K12818] [EC:5.6.2.6]
TVAG_2v0252320  RNA splicing [KO:K12819]
TVAG_2v1036500  ATP-dependent RNA helicase family [KO:K12820] [EC:5.6.2.6]
TVAG_2v0999400  ATP-dependent RNA helicase family [KO:K12820] [EC:5.6.2.6]
TVAG_2v0842170  mRNA splicing, via spliceosome [KO:K11086]
TVAG_2v0227780  spliceosomal snRNP assembly [KO:K11087]
TVAG_2v0448100  spliceosomal snRNP assembly [KO:K11096]
TVAG_2v0926550  U7 snRNA binding [KO:K11088]
TVAG_2v0169400  U7 snRNA binding [KO:K11088]
TVAG_2v0072650  spliceosomal snRNP assembly [KO:K11097]
TVAG_2v0077890  spliceosomal snRNP assembly [KO:K11098]
TVAG_2v0703170  small nuclear ribonucleoprotein G family [KO:K11099]
TVAG_2v0080540  small nuclear ribonucleoprotein G family [KO:K11099]
TVAG_2v0292090  small nuclear ribonucleoprotein G family [KO:K11099]
TVAG_2v0477730  snRNA binding [KO:K11093]
TVAG_2v0565150  mRNA splicing, via spliceosome [KO:K12821]
TVAG_2v0860700  ATP-dependent RNA helicase DBP3 family [KO:K12823] [EC:5.6.2.7]
TVAG_2v0827470  ATP-dependent RNA helicase DBP3 family [KO:K12823] [EC:5.6.2.7]
TVAG_2v0428240  U2 snRNA binding [KO:K11092]
TVAG_2v0078860  snRNA stem-loop binding [KO:K11094]
TVAG_2v0914760  snRNA stem-loop binding [KO:K11094]
TVAG_2v0522980  mRNA 3'-splice site recognition [KO:K12825]
TVAG_2v0266640  spliceosomal complex assembly [KO:K12826]
TVAG_2v0320990  splicing factor 3A subunit 3 family [KO:K12827]
TVAG_2v0916750  splicing factor 3B, subunit 1-related family [KO:K12828]
TVAG_2v0492960  mRNA splicing, via spliceosome [KO:K12829]
TVAG_2v0691530  RNA splicing [KO:K12830]
TVAG_2v0987780  DNA repair/RNA processing CPSF family [KO:K12830]
TVAG_2v0862470  RNA splicing [KO:K12831]
TVAG_2v0519260  RNA-binding domain, RBD family-containing protein [KO:K12831]
TVAG_2v0935040  mRNA splicing, via spliceosome [KO:K12832]
TVAG_2v0304390  RNA splicing [KO:K12833]
TVAG_2v1000570  mRNA splicing, via spliceosome [KO:K12834]
TVAG_2v0679830  RNA secondary structure unwinding [KO:K12835] [EC:5.6.2.7]
TVAG_2v0173220  pre-mRNA 3'-splice site binding [KO:K12836]
TVAG_2v0675650  pre-mRNA 3'-splice site binding [KO:K12836]
TVAG_2v0895500  pre-mRNA 3'-splice site binding [KO:K12836]
TVAG_2v0233560  pre-mRNA 3'-splice site binding [KO:K12836]
TVAG_2v0916440  pre-mRNA 3'-splice site binding [KO:K12836]
TVAG_2v0882170  RNA-binding protein family [KO:K12837]
TVAG_2v0552420  RNA-binding protein family [KO:K12837]
TVAG_2v0580360  RNA-binding protein family [KO:K12837]
TVAG_2v0277920  RNA-binding protein family [KO:K12837]
TVAG_2v0181460  mRNA splicing, via spliceosome [KO:K12621]
TVAG_2v0535830  cytoplasmic mRNA processing body assembly [KO:K12622]
TVAG_2v0839390  cytoplasmic mRNA processing body assembly [KO:K12622]
TVAG_2v0994400  U6 snRNA-associated [KO:K12625]
TVAG_2v0714660  U6 snRNA-associated [KO:K12625]
TVAG_2v0611480  mRNA splicing, via spliceosome [KO:K12843]
TVAG_2v0581600  U4 snRNA binding [KO:K12662]
TVAG_2v0485720  peptidyl-prolyl cis-trans isomerase protein [KO:K09567] [EC:5.2.1.8]
TVAG_2v0804730  spliceosomal tri-snRNP complex assembly [KO:K12844]
TVAG_2v0043390  U4atac snRNA binding [KO:K12845]
TVAG_2v0494500  hypothetical protein [KO:K12846]
TVAG_2v0302130  spliceosomal complex assembly [KO:K12847]
TVAG_2v0142060  RNA splicing [KO:K12849]
TVAG_2v0166220  116 kDa u5 small nuclear ribonucleoprotein component family [KO:K12852]
TVAG_2v0554420  pre-mRNA splicing factor family [KO:K12855]
TVAG_2v0413650  pre-mRNA processing protein 8 (Prp8) [KO:K12856]
TVAG_2v0029580  RNA splicing [KO:K12857]
TVAG_2v0181090  helicase protein [KO:K12858] [EC:5.6.2.7]
TVAG_2v0539970  spliceosomal complex assembly [KO:K12859]
TVAG_2v0877220  pre-mRNA-processing factor 19 family [KO:K10599] [EC:2.3.2.27]
TVAG_2v0328340  RNA polymerase II transcription regulator recruiting protein [KO:K12860]
TVAG_2v0143880  RNA polymerase II transcription regulator recruiting protein [KO:K12860]
TVAG_2v1010360  mRNA splicing, via spliceosome [KO:K12862]
TVAG_2v0249320  mRNA splicing, via spliceosome [KO:K12863]
TVAG_2v0986470  somatic diversification of immunoglobulins [KO:K12864]
TVAG_2v0726450  heat shock protein 70 (HSP70)-4 [KO:K03283]
TVAG_2v0616190  ATP binding [KO:K03283]
TVAG_2v0155340  heat shock protein 70 [KO:K03283]
TVAG_2v0820990  ATP binding [KO:K03283]
TVAG_2v0564030  ATP binding [KO:K03283]
TVAG_2v0311620  unfolded protein binding [KO:K03283]
TVAG_2v1004440  ATP binding [KO:K03283]
TVAG_2v0221200  cytoplasmic heat shock protein 70 [KO:K03283]
TVAG_2v0228100  cytoplasmic heat shock protein 70 [KO:K03283]
TVAG_2v0147430  unfolded protein binding [KO:K03283]
TVAG_2v0519190  cytoplasmic heat shock protein 70 [KO:K03283]
TVAG_2v0848700  ATP binding [KO:K03283]
TVAG_2v0784190  ATP binding [KO:K03283]
TVAG_2v0505280  ATP binding [KO:K03283]
TVAG_2v0416420  ATP binding [KO:K03283]
TVAG_2v0558740  heat shock protein 70 [KO:K03283]
TVAG_2v0837910  ATP binding [KO:K03283]
TVAG_2v1010330  ATP binding [KO:K03283]
TVAG_2v1010520  ATP binding [KO:K03283]
TVAG_2v0336150  HSP70 NBD domain-containing protein [KO:K03283]
TVAG_2v0950890  cytoplasmic heat shock protein 70 [KO:K03283]
TVAG_2v0688240  ATP binding [KO:K03283]
TVAG_2v0776460  ATP binding [KO:K03283]
TVAG_2v0300820  cytoplasmic heat shock protein 70 [KO:K03283]
TVAG_2v0916300  cytoplasmic heat shock protein 70 [KO:K03283]
TVAG_2v0414440  ATP binding [KO:K03283]
TVAG_2v0272020  nuclear protein, SKIP-related family [KO:K06063]
TVAG_2v0542410  pre-mRNA splicing factor family [KO:K12867]
TVAG_2v0210940  SYF2 splicing factor family [KO:K12868]
TVAG_2v0609950  pre-mRNA splicing factor family [KO:K12869]
TVAG_2v0602810  nuclear protein, SKIP-related family [KO:K12870]
TVAG_2v0931360  BUD31-like protein [KO:K12873]
TVAG_2v0960550  mRNA splicing, via spliceosome [KO:K12874]
TVAG_2v0616030  helicase protein [KO:K13025] [EC:5.6.2.7]
TVAG_2v0232710  mRNA transport [KO:K12879]
TVAG_2v0955660  pre-mRNA 5' cap binding protein family [KO:K12882]
TVAG_2v0120600  RNA cap binding [KO:K12883]
TVAG_2v0242300  regulation of alternative mRNA splicing, via spliceosome [KO:K12891]
TVAG_2v0542550  RNA recognition motif-containing protein [KO:K12891]
TVAG_2v0587980  peptidyl-prolyl cis-trans isomerase protein [KO:K12891]
TVAG_2v0076270  RNA-binding domain, RBD family-containing protein [KO:K12897]
TVAG_2v0175750  RNA binding [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (118)   
   KEGG GENES (118)   
All databases (119)   

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