KEGG   PATHWAY: tva03420
Entry
tva03420                    Pathway                                
Name
Nucleotide excision repair - Trichomonas vaginalis
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
tva03420  Nucleotide excision repair
tva03420

Other DBs
GO: 0006289
Organism
Trichomonas vaginalis [GN:tva]
Gene
TVAG_2v0582920  NEDD8 transferase protein [KO:K03868] [EC:2.3.2.32]
TVAG_2v1003330  NEDD8 transferase protein [KO:K03868] [EC:2.3.2.32]
TVAG_2v1003460  NEDD8 transferase protein [KO:K03868] [EC:2.3.2.32]
TVAG_2v0076970  ubiquitin protein ligase binding [KO:K10609]
TVAG_2v0424950  Cullin homology domain family [KO:K10609]
TVAG_2v0194760  Cullin homology domain family [KO:K10609]
TVAG_2v0001800  ubiquitin protein ligase binding [KO:K10609]
TVAG_2v0901630  Cullin homology domain family [KO:K10609]
TVAG_2v0946520  Cullin homology domain family [KO:K10609]
TVAG_2v0427820  ubiquitin protein ligase binding [KO:K10609]
TVAG_2v0265740  ubiquitin protein ligase binding [KO:K10609]
TVAG_2v0342420  ubiquitin protein ligase binding [KO:K10609]
TVAG_2v0546460  DNA repair/RNA processing CPSF family [KO:K10610]
TVAG_2v0173740  DNA repair/RNA processing CPSF family [KO:K10610]
TVAG_2v0711610  DNA repair/RNA processing CPSF family [KO:K10610]
TVAG_2v0999190  DNA repair/RNA processing CPSF family [KO:K10610]
TVAG_2v0281480  UV excision repair protein RAD23 family [KO:K10839]
TVAG_2v0845260  UV excision repair protein RAD23 family [KO:K10839]
TVAG_2v1041590  UV excision repair protein RAD23 family [KO:K10839]
TVAG_2v0735880  UV excision repair protein RAD23 family [KO:K10839]
TVAG_2v0165780  UV excision repair protein RAD23 family [KO:K10839]
TVAG_2v0014760  UV excision repair protein RAD23 family [KO:K10839]
TVAG_2v0985900  transcription-coupled nucleotide-excision repair [KO:K10570]
TVAG_2v0222420  DNA excision repair protein ERCC-6-related family [KO:K10841]
TVAG_2v0560240  DNA-directed RNA polymerase [KO:K03006] [EC:2.7.7.6]
TVAG_2v0339600  beta and beta-prime subunits of DNA dependent RNA-polymerase family [KO:K03010] [EC:2.7.7.6]
TVAG_2v0148730  DNA-directed 5'-3' RNA polymerase protein [KO:K03011]
TVAG_2v0529650  HRDC-like family [KO:K03012]
TVAG_2v0608470  DNA-directed 5'-3' RNA polymerase protein [KO:K03013]
TVAG_2v0530480  DNA-directed 5'-3' RNA polymerase protein [KO:K03013]
TVAG_2v0969670  DNA-directed 5'-3' RNA polymerase protein [KO:K03014]
TVAG_2v1022270  DNA-directed 5'-3' RNA polymerase protein [KO:K03014]
TVAG_2v0962540  DNA-directed 5'-3' RNA polymerase protein [KO:K03014]
TVAG_2v0144530  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [KO:K03015]
TVAG_2v0388210  transcription by RNA polymerase I [KO:K03016]
TVAG_2v0166340  DNA-directed RNA polymerase [KO:K03017]
TVAG_2v0376610  DNA-directed 5'-3' RNA polymerase protein [KO:K03007]
TVAG_2v0577630  RNA polymerase ii, chain L domain-containing protein [KO:K03009]
TVAG_2v0569180  RNA polymerase ii, chain L domain-containing protein [KO:K03009]
TVAG_2v0385410  RNA polymerase II protein [KO:K03008]
TVAG_2v0282490  positive regulation of phosphorylation of RNA polymerase II C-terminal domain [KO:K06634]
TVAG_2v0550040  Rad25/XP-B DNA repair helicase family [KO:K10843] [EC:5.6.2.4]
TVAG_2v0175660  Rad25/XP-B DNA repair helicase family [KO:K10843] [EC:5.6.2.4]
TVAG_2v0502750  DNA repair DEAD helicase RAD3/XP-D subfamily member family [KO:K10844] [EC:5.6.2.3]
TVAG_2v0505910  DNA repair DEAD helicase RAD3/XP-D subfamily member family [KO:K10844] [EC:5.6.2.3]
TVAG_2v0992530  TFIIH subunit TTDA/Tfb5 family [KO:K10845]
TVAG_2v0407650  nucleotide-excision repair [KO:K03142]
TVAG_2v0405730  nucleotide-excision repair [KO:K03142]
TVAG_2v0586200  phosphorylation of RNA polymerase II C-terminal domain [KO:K03143]
TVAG_2v0166200  phosphorylation of RNA polymerase II C-terminal domain [KO:K03144]
TVAG_2v0958330  nucleotide-excision repair, DNA incision, 3'-to lesion [KO:K10846]
TVAG_2v0273870  DNA recombination [KO:K07466]
TVAG_2v0982490  DNA metabolic process [KO:K10739]
TVAG_2v0062560  single-stranded DNA binding protein 12k chain [KO:K10740]
TVAG_2v1001000  DNA repair nuclease Rad1 [KO:K10848] [EC:3.1.-.-]
TVAG_2v0382730  meiotic mismatch repair [KO:K10849]
TVAG_2v0043000  DNA polymerase zeta catalytic subunit family [KO:K02327] [EC:2.7.7.7]
TVAG_2v0960650  DNA polymerase catalytic subunit family [KO:K02327] [EC:2.7.7.7]
TVAG_2v0268000  DNA polymerase delta family [KO:K02328]
TVAG_2v0599640  DNA replication proofreading [KO:K02324] [EC:2.7.7.7]
TVAG_2v0586170  error-prone translesion synthesis [KO:K02325] [EC:2.7.7.7]
TVAG_2v0936890  DNA polymerase processivity factor protein [KO:K04802]
TVAG_2v0961780  DNA polymerase processivity factor protein [KO:K04802]
TVAG_2v0221340  DNA clamp loader protein [KO:K10754]
TVAG_2v0947390  chromosome transmission fidelity factor 18 family [KO:K10754]
TVAG_2v0677490  DNA clamp loader protein [KO:K10754]
TVAG_2v0493120  DNA replication [KO:K10755]
TVAG_2v0219240  DNA replication [KO:K10755]
TVAG_2v1077760  replication factor C / DNA polymerase III gamma-tau subunit family [KO:K10755]
TVAG_2v0952230  DNA replication [KO:K10756]
TVAG_2v1000890  DNA replication [KO:K10756]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
tva03020  RNA polymerase
tva04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (71)   
   KEGG GENES (71)   
All databases (72)   

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