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Database: PDB
Entry: 1APJ
LinkDB: 1APJ
Original site: 1APJ 
HEADER    EXTRACELLULAR MATRIX                    22-JUL-97   1APJ              
TITLE     NMR STUDY OF THE TRANSFORMING GROWTH FACTOR BETA BINDING              
TITLE    2 PROTEIN-LIKE DOMAIN (TB MODULE/8-CYS DOMAIN), NMR, 21                
TITLE    3 STRUCTURES                                                           
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: FIBRILLIN;                                                 
COMPND   3 CHAIN: A;                                                            
COMPND   4 FRAGMENT: TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN-           
COMPND   5 LIKE DOMAIN 6(TB6), RESIDUES 2054 - 2125;                            
COMPND   6 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 FRAGMENT: TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN-           
SOURCE   3 LIKE DOMAIN 6(TB6), RESIDUES 2054-2125;                              
SOURCE   4 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   5 ORGANISM_COMMON: HUMAN;                                              
SOURCE   6 ORGANISM_TAXID: 9606;                                                
SOURCE   7 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   9 EXPRESSION_SYSTEM_STRAIN: NM554;                                     
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PQE30                                     
KEYWDS    FIBRILLIN FRAGMENT, MICROFIBRIL, TB MODULE, MARFAN SYNDROME,          
KEYWDS   2 CONNECTIVE TISSUE, NOVEL FOLD, EXTRACELLULAR MATRIX                  
EXPDTA    SOLUTION NMR                                                          
NUMMDL    21                                                                    
AUTHOR    X.YUAN,A.K.DOWNING,V.KNOTT,P.A.HANDFORD                               
REVDAT   2   24-FEB-09 1APJ    1       VERSN                                    
REVDAT   1   28-JAN-98 1APJ    0                                                
JRNL        AUTH   X.YUAN,A.K.DOWNING,V.KNOTT,P.A.HANDFORD                      
JRNL        TITL   SOLUTION STRUCTURE OF THE TRANSFORMING GROWTH                
JRNL        TITL 2 FACTOR BETA-BINDING PROTEIN-LIKE MODULE, A DOMAIN            
JRNL        TITL 3 ASSOCIATED WITH MATRIX FIBRILS.                              
JRNL        REF    EMBO J.                       V.  16  6659 1997              
JRNL        REFN                   ISSN 0261-4189                               
JRNL        PMID   9362480                                                      
JRNL        DOI    10.1093/EMBOJ/16.22.6659                                     
REMARK   1                                                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION. NOT APPLICABLE.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : X-PLOR 3.1                                           
REMARK   3   AUTHORS     : BRUNGER                                              
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 1APJ COMPLIES WITH FORMAT V. 3.15, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY BNL.                                
REMARK 210                                                                      
REMARK 210 EXPERIMENTAL DETAILS                                                 
REMARK 210  EXPERIMENT TYPE                : NMR                                
REMARK 210  TEMPERATURE           (KELVIN) : NULL                               
REMARK 210  PH                             : NULL                               
REMARK 210  IONIC STRENGTH                 : NULL                               
REMARK 210  PRESSURE                       : NULL                               
REMARK 210  SAMPLE CONTENTS                : NULL                               
REMARK 210                                                                      
REMARK 210  NMR EXPERIMENTS CONDUCTED      : NULL                               
REMARK 210  SPECTROMETER FIELD STRENGTH    : NULL                               
REMARK 210  SPECTROMETER MODEL             : NULL                               
REMARK 210  SPECTROMETER MANUFACTURER      : NULL                               
REMARK 210                                                                      
REMARK 210  STRUCTURE DETERMINATION.                                            
REMARK 210   SOFTWARE USED                 : NULL                               
REMARK 210   METHOD USED                   : NULL                               
REMARK 210                                                                      
REMARK 210 CONFORMERS, NUMBER CALCULATED   : NULL                               
REMARK 210 CONFORMERS, NUMBER SUBMITTED    : 21                                 
REMARK 210 CONFORMERS, SELECTION CRITERIA  : NULL                               
REMARK 210                                                                      
REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : NULL                
REMARK 210                                                                      
REMARK 210 REMARK: NULL                                                         
REMARK 215                                                                      
REMARK 215 NMR STUDY                                                            
REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION           
REMARK 215 NMR DATA.  PROTEIN DATA BANK CONVENTIONS REQUIRE THAT                
REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON              
REMARK 215 THESE RECORDS ARE MEANINGLESS.                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500  1 LEU A2056       47.26     27.72                                   
REMARK 500  1 SER A2059     -163.17   -113.14                                   
REMARK 500  1 GLU A2066       57.24    -91.20                                   
REMARK 500  1 SER A2072       56.65     70.95                                   
REMARK 500  1 CYS A2085      -62.71   -106.64                                   
REMARK 500  1 LYS A2088       73.66     28.10                                   
REMARK 500  1 CYS A2096      125.51    -28.10                                   
REMARK 500  1 SER A2115       88.44    -54.92                                   
REMARK 500  1 ILE A2117      -85.92     51.05                                   
REMARK 500  1 VAL A2119      116.29    -36.66                                   
REMARK 500  1 ASP A2122       27.58     43.92                                   
REMARK 500  1 SER A2124      165.56    158.49                                   
REMARK 500  2 ALA A   2     -178.36     53.12                                   
REMARK 500  2 LEU A2056       41.90     38.18                                   
REMARK 500  2 SER A2059     -159.24   -116.44                                   
REMARK 500  2 SER A2079      153.55    -41.64                                   
REMARK 500  2 LYS A2088       77.60     30.45                                   
REMARK 500  2 CYS A2096      123.81    -27.22                                   
REMARK 500  2 PRO A2103       31.78    -92.62                                   
REMARK 500  2 SER A2115       67.23   -100.60                                   
REMARK 500  2 ILE A2117      -77.87    -26.12                                   
REMARK 500  2 ILE A2118       66.32    167.12                                   
REMARK 500  2 ASP A2122      -47.43     87.29                                   
REMARK 500  2 SER A2124       97.11     59.48                                   
REMARK 500  3 ALA A   2     -161.08    173.68                                   
REMARK 500  3 GLN A2054     -174.82    -49.03                                   
REMARK 500  3 ASP A2055       45.79    -89.00                                   
REMARK 500  3 LEU A2056       22.94     45.65                                   
REMARK 500  3 SER A2059     -161.25   -120.47                                   
REMARK 500  3 LYS A2088       70.12     31.00                                   
REMARK 500  3 CYS A2096      111.28    -27.45                                   
REMARK 500  3 LEU A2098       95.29    -35.39                                   
REMARK 500  3 PRO A2103       31.39    -94.04                                   
REMARK 500  3 ILE A2117      -86.27     49.16                                   
REMARK 500  3 VAL A2119      -37.53    -29.33                                   
REMARK 500  3 SER A2124      -56.94   -166.36                                   
REMARK 500  4 ALA A   2      139.11     65.92                                   
REMARK 500  4 ASP A2055       93.75     57.37                                   
REMARK 500  4 SER A2059     -165.36   -107.59                                   
REMARK 500  4 SER A2075      -35.99    -37.62                                   
REMARK 500  4 ARG A2076     -169.43   -109.15                                   
REMARK 500  4 LYS A2088       77.14     30.08                                   
REMARK 500  4 CYS A2096      122.12    -26.92                                   
REMARK 500  4 LEU A2098      110.36    -37.67                                   
REMARK 500  4 PRO A2103       30.44    -94.63                                   
REMARK 500  4 SER A2115       88.25    -47.37                                   
REMARK 500  4 ILE A2117      -86.65     61.53                                   
REMARK 500  4 VAL A2119      -44.76    -29.53                                   
REMARK 500  4 PRO A2121       86.00    -44.86                                   
REMARK 500  4 ASP A2122       38.74     38.22                                   
REMARK 500  5 ALA A   2      129.19     69.17                                   
REMARK 500  5 LEU A2056       41.79     32.14                                   
REMARK 500  5 LYS A2088       67.83     29.08                                   
REMARK 500  5 CYS A2096      124.18    -27.34                                   
REMARK 500  5 LEU A2098      116.78    -31.83                                   
REMARK 500  5 SER A2115       84.35    -66.82                                   
REMARK 500  5 VAL A2119      -34.86    -36.54                                   
REMARK 500  5 PRO A2121       87.66    -62.25                                   
REMARK 500  5 ASP A2122      -27.79    165.16                                   
REMARK 500  5 ASP A2123       70.92   -118.17                                   
REMARK 500  5 SER A2124      144.67    -35.76                                   
REMARK 500  6 LEU A2056       47.42     36.33                                   
REMARK 500  6 SER A2059     -161.34   -113.41                                   
REMARK 500  6 SER A2079      149.50    -32.17                                   
REMARK 500  6 LYS A2088       73.32     25.96                                   
REMARK 500  6 CYS A2096      119.79    -27.38                                   
REMARK 500  6 LEU A2098      131.82    -31.99                                   
REMARK 500  6 PRO A2103       33.91    -93.19                                   
REMARK 500  6 ILE A2117      -48.92   -147.64                                   
REMARK 500  6 VAL A2119      -47.10    -19.06                                   
REMARK 500  6 PRO A2121       96.02    -44.49                                   
REMARK 500  6 ASP A2122      -40.69     85.38                                   
REMARK 500  6 ASP A2123       39.55     81.77                                   
REMARK 500  6 SER A2124      165.54    169.61                                   
REMARK 500  7 GLN A2054       83.81    -69.72                                   
REMARK 500  7 LEU A2056       43.32     30.91                                   
REMARK 500  7 SER A2072       60.41     68.93                                   
REMARK 500  7 LYS A2074      125.22    -39.91                                   
REMARK 500  7 CYS A2085      -62.52   -125.70                                   
REMARK 500  7 LYS A2088       90.53     44.89                                   
REMARK 500  7 CYS A2096      126.67    -27.26                                   
REMARK 500  7 SER A2115       44.01    -84.78                                   
REMARK 500  7 ILE A2117      -40.23   -155.65                                   
REMARK 500  7 ILE A2118       56.25    130.12                                   
REMARK 500  7 PRO A2121       83.64    -59.30                                   
REMARK 500  7 ASP A2122       32.79     33.76                                   
REMARK 500  7 ASP A2123       39.03    -90.18                                   
REMARK 500  7 SER A2124       30.02    -95.65                                   
REMARK 500  8 ALA A   2      109.04     56.23                                   
REMARK 500  8 ASP A2055       28.68     44.70                                   
REMARK 500  8 LEU A2056       47.33     26.83                                   
REMARK 500  8 GLU A2066     -167.62    -79.53                                   
REMARK 500  8 SER A2072       60.32     79.49                                   
REMARK 500  8 LYS A2074       45.18    -82.95                                   
REMARK 500  8 SER A2075      -89.23     34.02                                   
REMARK 500  8 CYS A2085      -41.54   -133.78                                   
REMARK 500  8 LYS A2088       71.68     26.23                                   
REMARK 500  8 CYS A2096      126.45    -27.25                                   
REMARK 500  8 LEU A2098      108.60    -32.22                                   
REMARK 500  8 SER A2115       87.43    -45.41                                   
REMARK 500  8 VAL A2119      -34.18    -32.47                                   
REMARK 500  8 PRO A2121       83.73    -48.00                                   
REMARK 500  8 ASP A2123       82.28     45.70                                   
REMARK 500  8 SER A2124      108.10    -33.69                                   
REMARK 500  9 GLN A2054       51.89   -111.87                                   
REMARK 500  9 LEU A2056       47.28     29.70                                   
REMARK 500  9 SER A2059     -160.67   -127.93                                   
REMARK 500  9 LYS A2074     -168.25    -50.42                                   
REMARK 500  9 CYS A2085      -36.24   -130.95                                   
REMARK 500  9 CYS A2096      120.42    -27.05                                   
REMARK 500  9 SER A2115       87.36    -51.81                                   
REMARK 500  9 ILE A2117      -86.98     52.93                                   
REMARK 500  9 VAL A2119      -84.21    -24.78                                   
REMARK 500  9 PRO A2121       43.13    -82.86                                   
REMARK 500  9 ASP A2122      -31.26    173.05                                   
REMARK 500  9 SER A2124      -86.91    -87.21                                   
REMARK 500 10 LEU A2056       49.20     25.23                                   
REMARK 500 10 GLU A2066       57.53    -92.96                                   
REMARK 500 10 LYS A2074      157.07    -49.42                                   
REMARK 500 10 ARG A2076     -158.58    -85.21                                   
REMARK 500 10 LYS A2088       50.93     23.43                                   
REMARK 500 10 CYS A2096      132.83    -27.61                                   
REMARK 500 10 LEU A2098      113.04    -37.58                                   
REMARK 500 10 PRO A2103       30.34    -94.00                                   
REMARK 500 10 ILE A2117       34.23     32.42                                   
REMARK 500 10 ILE A2118       54.46     27.00                                   
REMARK 500 10 VAL A2119      -27.76    -37.57                                   
REMARK 500 10 ASP A2123       39.83    -86.86                                   
REMARK 500 11 ALA A   2     -170.32     58.48                                   
REMARK 500 11 GLN A2054     -169.70    -76.07                                   
REMARK 500 11 LEU A2056       23.02     49.99                                   
REMARK 500 11 TYR A2060      131.27    -33.68                                   
REMARK 500 11 SER A2072       61.84     67.79                                   
REMARK 500 11 LYS A2088       72.24     56.76                                   
REMARK 500 11 CYS A2096      122.91    -27.23                                   
REMARK 500 11 LEU A2098      114.85    -34.39                                   
REMARK 500 11 SER A2115       89.16    -51.86                                   
REMARK 500 11 ILE A2117      -85.94     56.43                                   
REMARK 500 11 ILE A2118       72.66   -119.25                                   
REMARK 500 11 VAL A2119      -32.76    -33.88                                   
REMARK 500 11 PRO A2121       81.47    -67.35                                   
REMARK 500 11 SER A2124       95.52     36.94                                   
REMARK 500 12 ALA A   2     -172.13     51.24                                   
REMARK 500 12 ASP A2055       92.01    -41.44                                   
REMARK 500 12 LEU A2056      -27.15    -36.64                                   
REMARK 500 12 SER A2079      167.83    -43.29                                   
REMARK 500 12 LYS A2088       84.88     31.27                                   
REMARK 500 12 CYS A2096      125.11    -27.45                                   
REMARK 500 12 PRO A2103       33.55    -95.16                                   
REMARK 500 12 ILE A2117      -84.20    -20.56                                   
REMARK 500 12 ILE A2118       42.61    174.72                                   
REMARK 500 12 ASP A2122      -42.21   -155.62                                   
REMARK 500 13 LEU A2056       36.17     31.01                                   
REMARK 500 13 GLU A2066       48.82    -85.48                                   
REMARK 500 13 LYS A2074     -166.08    -53.43                                   
REMARK 500 13 SER A2079      154.45    -34.16                                   
REMARK 500 13 LYS A2088       77.81     30.79                                   
REMARK 500 13 CYS A2096      120.27    -27.13                                   
REMARK 500 13 LEU A2098      125.75    -32.59                                   
REMARK 500 13 SER A2115       80.35    -45.32                                   
REMARK 500 13 ILE A2118      -76.22    -94.02                                   
REMARK 500 13 ASP A2122       31.98     33.96                                   
REMARK 500 13 ASP A2123       40.44    -99.49                                   
REMARK 500 14 GLN A2054       59.51   -114.49                                   
REMARK 500 14 LEU A2056       39.46    -95.77                                   
REMARK 500 14 ARG A2057      148.83    -27.35                                   
REMARK 500 14 SER A2059     -161.03   -107.57                                   
REMARK 500 14 LYS A2088       97.23     59.85                                   
REMARK 500 14 CYS A2096      121.42    -27.44                                   
REMARK 500 14 LEU A2098      100.33    -33.23                                   
REMARK 500 14 PRO A2103       30.10    -93.86                                   
REMARK 500 14 SER A2115       89.63    -40.54                                   
REMARK 500 14 ILE A2117      -66.44    -13.39                                   
REMARK 500 14 ILE A2118       53.11    145.41                                   
REMARK 500 14 ASP A2122       38.53     35.62                                   
REMARK 500 14 ASP A2123       69.64   -119.36                                   
REMARK 500 15 LEU A2056       44.44     36.33                                   
REMARK 500 15 SER A2059     -158.87   -137.74                                   
REMARK 500 15 ALA A2063      -31.04    -32.81                                   
REMARK 500 15 GLU A2066       57.54    -91.54                                   
REMARK 500 15 SER A2072       61.83     61.91                                   
REMARK 500 15 SER A2075      -37.70    -37.67                                   
REMARK 500 15 SER A2079      143.68    -31.15                                   
REMARK 500 15 LYS A2088       73.36     31.31                                   
REMARK 500 15 CYS A2096      123.26    -27.49                                   
REMARK 500 15 LEU A2098      108.19    -55.59                                   
REMARK 500 15 PRO A2103       33.34    -97.80                                   
REMARK 500 15 SER A2115       63.25   -101.06                                   
REMARK 500 15 ILE A2118      -72.62    -91.86                                   
REMARK 500 15 PRO A2121       93.18    -38.54                                   
REMARK 500 15 ASP A2122      -25.57    159.34                                   
REMARK 500 15 ASP A2123       59.43   -145.39                                   
REMARK 500 15 SER A2124      -43.04   -178.95                                   
REMARK 500 16 ALA A   2     -172.28    159.05                                   
REMARK 500 16 SER A2072       59.31     82.83                                   
REMARK 500 16 LYS A2074      173.29    -58.29                                   
REMARK 500 16 SER A2079      142.79    -34.36                                   
REMARK 500 16 LYS A2088       82.37     30.03                                   
REMARK 500 16 CYS A2096      107.88    -27.92                                   
REMARK 500 16 LEU A2098      118.19    -35.16                                   
REMARK 500 16 PRO A2103       30.61    -91.05                                   
REMARK 500 16 SER A2115       88.17    -52.86                                   
REMARK 500 16 ILE A2117      -70.67     -9.12                                   
REMARK 500 16 ILE A2118       60.76    152.34                                   
REMARK 500 16 SER A2124       69.29     34.75                                   
REMARK 500 17 ASP A2055       29.80     47.05                                   
REMARK 500 17 LEU A2056       38.33     29.18                                   
REMARK 500 17 SER A2072       60.14     69.30                                   
REMARK 500 17 SER A2075      -39.54    -39.20                                   
REMARK 500 17 ARG A2076     -163.30   -129.78                                   
REMARK 500 17 LYS A2088       72.24     33.01                                   
REMARK 500 17 CYS A2096      133.94    -27.01                                   
REMARK 500 17 VAL A2119      -37.01    -29.79                                   
REMARK 500 17 ASP A2122      -35.66     85.92                                   
REMARK 500 17 SER A2124      -75.47    -35.02                                   
REMARK 500 18 ALA A   2      136.87    169.07                                   
REMARK 500 18 ASP A2055       29.67     41.19                                   
REMARK 500 18 LEU A2056       44.53     29.05                                   
REMARK 500 18 SER A2059     -159.53   -118.31                                   
REMARK 500 18 LYS A2088       85.67     39.57                                   
REMARK 500 18 CYS A2096      124.36    -27.32                                   
REMARK 500 18 LEU A2098      116.44    -35.10                                   
REMARK 500 18 SER A2115       88.17    -51.92                                   
REMARK 500 18 ILE A2117      -82.50     26.80                                   
REMARK 500 18 ILE A2118       75.63   -111.24                                   
REMARK 500 18 PRO A2121       84.53    -43.79                                   
REMARK 500 18 ASP A2122       28.34     39.16                                   
REMARK 500 18 ASP A2123       75.52     51.82                                   
REMARK 500 18 SER A2124      170.19    -45.26                                   
REMARK 500 19 ASP A2055       32.41     35.85                                   
REMARK 500 19 LEU A2056       49.83     26.92                                   
REMARK 500 19 SER A2059     -162.35   -128.16                                   
REMARK 500 19 SER A2072       58.23     72.73                                   
REMARK 500 19 LYS A2088       69.66     32.13                                   
REMARK 500 19 CYS A2096      129.64    -27.06                                   
REMARK 500 19 LEU A2098      106.79    -37.40                                   
REMARK 500 19 SER A2115       87.17    -48.30                                   
REMARK 500 19 VAL A2119      -38.05    -31.35                                   
REMARK 500 19 SER A2124      -75.17    -35.76                                   
REMARK 500 20 ALA A   2     -179.02     63.40                                   
REMARK 500 20 GLN A2054     -151.12    -71.93                                   
REMARK 500 20 SER A2072       59.64     71.10                                   
REMARK 500 20 SER A2079      153.77    -32.04                                   
REMARK 500 20 LYS A2088       74.43     34.50                                   
REMARK 500 20 CYS A2096      121.25    -27.29                                   
REMARK 500 20 LEU A2098      127.42    -32.75                                   
REMARK 500 20 SER A2115       87.75    -53.58                                   
REMARK 500 20 ILE A2118       75.11   -156.46                                   
REMARK 500 20 VAL A2119      -67.23    -24.69                                   
REMARK 500 20 PRO A2121       89.57    -58.63                                   
REMARK 500 20 ASP A2122       37.73     29.05                                   
REMARK 500 20 ASP A2123       73.15   -102.18                                   
REMARK 500 21 ASP A2055       32.00     34.31                                   
REMARK 500 21 LEU A2056       72.00   -107.66                                   
REMARK 500 21 ARG A2057      134.26    -28.85                                   
REMARK 500 21 ALA A2063      -28.85    -39.85                                   
REMARK 500 21 SER A2072       64.90     78.45                                   
REMARK 500 21 SER A2079      154.12    -36.22                                   
REMARK 500 21 LYS A2088       95.06     50.41                                   
REMARK 500 21 CYS A2096      128.24    -27.09                                   
REMARK 500 21 LEU A2098      119.95    -32.58                                   
REMARK 500 21 PRO A2103       30.54    -93.50                                   
REMARK 500 21 ASP A2104      154.41    -48.06                                   
REMARK 500 21 ILE A2117      -82.83    -26.61                                   
REMARK 500 21 ILE A2118       59.99    173.68                                   
REMARK 500 21 ASP A2122       38.10     33.36                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500  1 ARG A2057         0.29    SIDE_CHAIN                              
REMARK 500  1 ARG A2076         0.25    SIDE_CHAIN                              
REMARK 500  2 ARG A2057         0.20    SIDE_CHAIN                              
REMARK 500  2 ARG A2076         0.19    SIDE_CHAIN                              
REMARK 500  2 ARG A2108         0.31    SIDE_CHAIN                              
REMARK 500  3 ARG A2057         0.10    SIDE_CHAIN                              
REMARK 500  3 ARG A2076         0.31    SIDE_CHAIN                              
REMARK 500  4 ARG A2057         0.12    SIDE_CHAIN                              
REMARK 500  4 ARG A2076         0.16    SIDE_CHAIN                              
REMARK 500  5 ARG A2057         0.26    SIDE_CHAIN                              
REMARK 500  5 ARG A2076         0.21    SIDE_CHAIN                              
REMARK 500  5 ARG A2108         0.17    SIDE_CHAIN                              
REMARK 500  6 ARG A2057         0.21    SIDE_CHAIN                              
REMARK 500  6 ARG A2076         0.30    SIDE_CHAIN                              
REMARK 500  6 ARG A2108         0.14    SIDE_CHAIN                              
REMARK 500  7 ARG A2057         0.11    SIDE_CHAIN                              
REMARK 500  7 ARG A2076         0.25    SIDE_CHAIN                              
REMARK 500  7 ARG A2108         0.30    SIDE_CHAIN                              
REMARK 500  8 ARG A2057         0.28    SIDE_CHAIN                              
REMARK 500  8 ARG A2076         0.29    SIDE_CHAIN                              
REMARK 500  8 ARG A2108         0.30    SIDE_CHAIN                              
REMARK 500  9 ARG A2057         0.23    SIDE_CHAIN                              
REMARK 500  9 ARG A2076         0.25    SIDE_CHAIN                              
REMARK 500  9 ARG A2108         0.30    SIDE_CHAIN                              
REMARK 500 10 ARG A2057         0.16    SIDE_CHAIN                              
REMARK 500 10 ARG A2108         0.28    SIDE_CHAIN                              
REMARK 500 11 ARG A2057         0.08    SIDE_CHAIN                              
REMARK 500 11 ARG A2076         0.23    SIDE_CHAIN                              
REMARK 500 11 ARG A2108         0.08    SIDE_CHAIN                              
REMARK 500 12 ARG A2057         0.21    SIDE_CHAIN                              
REMARK 500 12 ARG A2076         0.20    SIDE_CHAIN                              
REMARK 500 12 ARG A2108         0.30    SIDE_CHAIN                              
REMARK 500 13 ARG A2057         0.25    SIDE_CHAIN                              
REMARK 500 13 ARG A2076         0.26    SIDE_CHAIN                              
REMARK 500 13 ARG A2108         0.26    SIDE_CHAIN                              
REMARK 500 14 ARG A2057         0.31    SIDE_CHAIN                              
REMARK 500 14 ARG A2076         0.30    SIDE_CHAIN                              
REMARK 500 14 ARG A2108         0.23    SIDE_CHAIN                              
REMARK 500 15 ARG A2057         0.27    SIDE_CHAIN                              
REMARK 500 15 ARG A2076         0.21    SIDE_CHAIN                              
REMARK 500 16 ARG A2057         0.24    SIDE_CHAIN                              
REMARK 500 16 ARG A2076         0.29    SIDE_CHAIN                              
REMARK 500 17 ARG A2057         0.14    SIDE_CHAIN                              
REMARK 500 17 ARG A2076         0.29    SIDE_CHAIN                              
REMARK 500 17 ARG A2108         0.31    SIDE_CHAIN                              
REMARK 500 18 ARG A2057         0.28    SIDE_CHAIN                              
REMARK 500 18 ARG A2076         0.23    SIDE_CHAIN                              
REMARK 500 18 ARG A2108         0.27    SIDE_CHAIN                              
REMARK 500 19 ARG A2057         0.29    SIDE_CHAIN                              
REMARK 500 19 ARG A2076         0.31    SIDE_CHAIN                              
REMARK 500 19 ARG A2108         0.22    SIDE_CHAIN                              
REMARK 500 20 ARG A2057         0.27    SIDE_CHAIN                              
REMARK 500 20 ARG A2108         0.29    SIDE_CHAIN                              
REMARK 500 21 ARG A2076         0.18    SIDE_CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
DBREF  1APJ A    1  2125  UNP    P35555   FBN1_HUMAN    2049   2125             
SEQADV 1APJ SER A    1  UNP  P35555    ARG  2052 ENGINEERED                     
SEQADV 1APJ ALA A    2  UNP  P35555    CYS  2053 ENGINEERED                     
SEQRES   1 A   74  SER ALA GLN ASP LEU ARG MET SER TYR CYS TYR ALA LYS          
SEQRES   2 A   74  PHE GLU GLY GLY LYS CYS SER SER PRO LYS SER ARG ASN          
SEQRES   3 A   74  HIS SER LYS GLN GLU CYS CYS CYS ALA LEU LYS GLY GLU          
SEQRES   4 A   74  GLY TRP GLY ASP PRO CYS GLU LEU CYS PRO THR GLU PRO          
SEQRES   5 A   74  ASP GLU ALA PHE ARG GLN ILE CYS PRO TYR GLY SER GLY          
SEQRES   6 A   74  ILE ILE VAL GLY PRO ASP ASP SER ALA                          
HELIX    1  H1 LYS A 2080  CYS A 2084  1                                   5    
HELIX    2  H2 GLU A 2105  ILE A 2110  1                                   6    
SHEET    1  S1 2 MET A2058  SER A2059  0                                        
SHEET    2  S1 2 HIS A2078  SER A2079 -1  O  HIS A2078   N  SER A2059           
SHEET    1  S2 4 GLU A2097  LEU A2098  0                                        
SHEET    2  S2 4 GLY A2091  TRP A2092 -1  N  TRP A2092   O  GLU A2097           
SHEET    3  S2 4 CYS A2061  PHE A2065 -1  N  TYR A2062   O  GLY A2091           
SHEET    4  S2 4 CYS A2070  PRO A2073 -1  O  SER A2072   N  ALA A2063           
SSBOND   1 CYS A 2061    CYS A 2083                          1555   1555  2.02  
SSBOND   2 CYS A 2070    CYS A 2096                          1555   1555  2.02  
SSBOND   3 CYS A 2084    CYS A 2099                          1555   1555  2.03  
SSBOND   4 CYS A 2085    CYS A 2111                          1555   1555  2.02  
CISPEP   1 GLU A 2102    PRO A 2103          1         0.10                     
CISPEP   2 GLU A 2102    PRO A 2103          2         0.06                     
CISPEP   3 GLU A 2102    PRO A 2103          3         0.25                     
CISPEP   4 GLU A 2102    PRO A 2103          4         0.13                     
CISPEP   5 GLU A 2102    PRO A 2103          5         0.14                     
CISPEP   6 GLU A 2102    PRO A 2103          6        -0.06                     
CISPEP   7 GLU A 2102    PRO A 2103          7         0.06                     
CISPEP   8 GLU A 2102    PRO A 2103          8         0.02                     
CISPEP   9 GLU A 2102    PRO A 2103          9         0.14                     
CISPEP  10 GLU A 2102    PRO A 2103         10         0.13                     
CISPEP  11 GLU A 2102    PRO A 2103         11         0.19                     
CISPEP  12 GLU A 2102    PRO A 2103         12         0.21                     
CISPEP  13 GLU A 2102    PRO A 2103         13        -0.01                     
CISPEP  14 GLU A 2102    PRO A 2103         14        -0.04                     
CISPEP  15 GLU A 2102    PRO A 2103         15         0.25                     
CISPEP  16 GLU A 2102    PRO A 2103         16         0.05                     
CISPEP  17 GLU A 2102    PRO A 2103         17         0.02                     
CISPEP  18 GLU A 2102    PRO A 2103         18        -0.14                     
CISPEP  19 GLU A 2102    PRO A 2103         19         0.12                     
CISPEP  20 GLU A 2102    PRO A 2103         20         0.14                     
CISPEP  21 GLU A 2102    PRO A 2103         21        -0.08                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
MODEL        1                                                                  
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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