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Database: PDB
Entry: 1CO1
LinkDB: 1CO1
Original site: 1CO1 
HEADER    GENE REGULATION                         31-MAY-99   1CO1              
TITLE     FOLD OF THE CBFA                                                      
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: CORE BINDING FACTOR ALPHA;                                 
COMPND   3 CHAIN: A;                                                            
COMPND   4 FRAGMENT: RUNT DOMAIN;                                               
COMPND   5 SYNONYM: AML1;                                                       
COMPND   6 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    CBFA RUNT AML-1 RUNT DOMAIN, GENE REGULATION                          
EXPDTA    SOLUTION NMR                                                          
NUMMDL    10                                                                    
AUTHOR    M.J.BERARDI,J.H.BUSHWELLER                                            
REVDAT   3   24-FEB-09 1CO1    1       VERSN                                    
REVDAT   2   01-APR-03 1CO1    1       JRNL                                     
REVDAT   1   07-JUN-00 1CO1    0                                                
JRNL        AUTH   M.J.BERARDI,C.SUN,M.ZEHR,F.ABILDGAARD,J.PENG,                
JRNL        AUTH 2 N.A.SPECK,J.H.BUSHWELLER                                     
JRNL        TITL   THE IG FOLD OF THE CORE BINDING FACTOR ALPHA RUNT            
JRNL        TITL 2 DOMAIN IS A MEMBER OF A FAMILY OF STRUCTURALLY AND           
JRNL        TITL 3 FUNCTIONALLY RELATED IG-FOLD DNA-BINDING DOMAINS.            
JRNL        REF    STRUCTURE FOLD.DES.           V.   7  1247 1999              
JRNL        REFN                   ISSN 0969-2126                               
JRNL        PMID   10545320                                                     
JRNL        DOI    10.1016/S0969-2126(00)80058-1                                
REMARK   1                                                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION. NOT APPLICABLE.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : OPAL 2.6                                             
REMARK   3   AUTHORS     : K. WURTRICH                                          
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 1CO1 COMPLIES WITH FORMAT V. 3.15, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 03-JUN-99.                  
REMARK 100 THE RCSB ID CODE IS RCSB001133.                                      
REMARK 210                                                                      
REMARK 210 EXPERIMENTAL DETAILS                                                 
REMARK 210  EXPERIMENT TYPE                : NMR                                
REMARK 210  TEMPERATURE           (KELVIN) : 313                                
REMARK 210  PH                             : 6.0                                
REMARK 210  IONIC STRENGTH                 : NULL                               
REMARK 210  PRESSURE                       : NULL                               
REMARK 210  SAMPLE CONTENTS                : NULL                               
REMARK 210                                                                      
REMARK 210  NMR EXPERIMENTS CONDUCTED      : NULL                               
REMARK 210  SPECTROMETER FIELD STRENGTH    : NULL                               
REMARK 210  SPECTROMETER MODEL             : NULL                               
REMARK 210  SPECTROMETER MANUFACTURER      : NULL                               
REMARK 210                                                                      
REMARK 210  STRUCTURE DETERMINATION.                                            
REMARK 210   SOFTWARE USED                 : NULL                               
REMARK 210   METHOD USED                   : NULL                               
REMARK 210                                                                      
REMARK 210 CONFORMERS, NUMBER CALCULATED   : NULL                               
REMARK 210 CONFORMERS, NUMBER SUBMITTED    : 10                                 
REMARK 210 CONFORMERS, SELECTION CRITERIA  : NULL                               
REMARK 210                                                                      
REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : NULL                
REMARK 210                                                                      
REMARK 210 REMARK: NULL                                                         
REMARK 215                                                                      
REMARK 215 NMR STUDY                                                            
REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION           
REMARK 215 NMR DATA.  PROTEIN DATA BANK CONVENTIONS REQUIRE THAT                
REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON              
REMARK 215 THESE RECORDS ARE MEANINGLESS.                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500  1 ARG A  24   NE  -  CZ  -  NH1 ANGL. DEV. =   3.9 DEGREES          
REMARK 500  1 ARG A  40   NE  -  CZ  -  NH1 ANGL. DEV. =   3.2 DEGREES          
REMARK 500  1 ARG A  90   NE  -  CZ  -  NH1 ANGL. DEV. =   3.6 DEGREES          
REMARK 500  1 ARG A  95   NE  -  CZ  -  NH1 ANGL. DEV. =   3.8 DEGREES          
REMARK 500  1 ARG A  99   NE  -  CZ  -  NH1 ANGL. DEV. =   4.2 DEGREES          
REMARK 500  1 ARG A 134   NE  -  CZ  -  NH1 ANGL. DEV. =   3.7 DEGREES          
REMARK 500  2 ARG A  24   NE  -  CZ  -  NH1 ANGL. DEV. =   4.1 DEGREES          
REMARK 500  2 ARG A  40   NE  -  CZ  -  NH1 ANGL. DEV. =   3.4 DEGREES          
REMARK 500  2 ARG A  78   NE  -  CZ  -  NH1 ANGL. DEV. =   3.5 DEGREES          
REMARK 500  2 ARG A  95   NE  -  CZ  -  NH1 ANGL. DEV. =   4.5 DEGREES          
REMARK 500  2 ARG A 124   NE  -  CZ  -  NH1 ANGL. DEV. =   4.2 DEGREES          
REMARK 500  2 ARG A 134   NE  -  CZ  -  NH1 ANGL. DEV. =   3.2 DEGREES          
REMARK 500  3 ARG A  24   NE  -  CZ  -  NH1 ANGL. DEV. =   4.4 DEGREES          
REMARK 500  3 ARG A  78   NE  -  CZ  -  NH1 ANGL. DEV. =   5.6 DEGREES          
REMARK 500  3 ARG A  99   NE  -  CZ  -  NH1 ANGL. DEV. =   4.3 DEGREES          
REMARK 500  3 ARG A 102   NE  -  CZ  -  NH1 ANGL. DEV. =   4.2 DEGREES          
REMARK 500  3 ARG A 134   NE  -  CZ  -  NH1 ANGL. DEV. =   3.0 DEGREES          
REMARK 500  4 ARG A  24   NE  -  CZ  -  NH1 ANGL. DEV. =   3.4 DEGREES          
REMARK 500  4 ARG A  40   NE  -  CZ  -  NH1 ANGL. DEV. =   3.4 DEGREES          
REMARK 500  5 ARG A  40   NE  -  CZ  -  NH1 ANGL. DEV. =   3.7 DEGREES          
REMARK 500  5 ARG A  78   NE  -  CZ  -  NH1 ANGL. DEV. =   3.5 DEGREES          
REMARK 500  5 ARG A  90   NE  -  CZ  -  NH1 ANGL. DEV. =   3.4 DEGREES          
REMARK 500  5 ARG A  95   CD  -  NE  -  CZ  ANGL. DEV. =  10.4 DEGREES          
REMARK 500  5 ARG A  95   NE  -  CZ  -  NH1 ANGL. DEV. =   5.8 DEGREES          
REMARK 500  5 ARG A  95   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.2 DEGREES          
REMARK 500  6 ARG A  24   NE  -  CZ  -  NH1 ANGL. DEV. =   3.2 DEGREES          
REMARK 500  6 VAL A  65   CA  -  CB  -  CG2 ANGL. DEV. =  10.4 DEGREES          
REMARK 500  6 ARG A  78   NE  -  CZ  -  NH1 ANGL. DEV. =   4.0 DEGREES          
REMARK 500  6 ARG A  90   NE  -  CZ  -  NH1 ANGL. DEV. =   4.1 DEGREES          
REMARK 500  6 ARG A  95   NE  -  CZ  -  NH1 ANGL. DEV. =   3.5 DEGREES          
REMARK 500  6 ARG A 124   NE  -  CZ  -  NH1 ANGL. DEV. =   3.1 DEGREES          
REMARK 500  6 ARG A 134   NE  -  CZ  -  NH1 ANGL. DEV. =   3.6 DEGREES          
REMARK 500  7 ARG A  24   NH1 -  CZ  -  NH2 ANGL. DEV. =  -7.4 DEGREES          
REMARK 500  7 ARG A  24   NE  -  CZ  -  NH1 ANGL. DEV. =   4.7 DEGREES          
REMARK 500  7 ARG A  40   NE  -  CZ  -  NH1 ANGL. DEV. =   5.0 DEGREES          
REMARK 500  7 ARG A  78   NE  -  CZ  -  NH1 ANGL. DEV. =   3.1 DEGREES          
REMARK 500  7 ARG A  95   NE  -  CZ  -  NH1 ANGL. DEV. =   3.9 DEGREES          
REMARK 500  7 ARG A 102   NE  -  CZ  -  NH1 ANGL. DEV. =   3.1 DEGREES          
REMARK 500  7 ARG A 124   NE  -  CZ  -  NH1 ANGL. DEV. =   3.1 DEGREES          
REMARK 500  7 ARG A 134   NE  -  CZ  -  NH1 ANGL. DEV. =   3.9 DEGREES          
REMARK 500  8 ARG A  24   NE  -  CZ  -  NH1 ANGL. DEV. =   3.4 DEGREES          
REMARK 500  8 ARG A  78   NE  -  CZ  -  NH1 ANGL. DEV. =   3.5 DEGREES          
REMARK 500  8 ARG A  95   NE  -  CZ  -  NH1 ANGL. DEV. =   5.4 DEGREES          
REMARK 500  9 ARG A  24   NE  -  CZ  -  NH1 ANGL. DEV. =   3.1 DEGREES          
REMARK 500  9 ARG A  78   NE  -  CZ  -  NH1 ANGL. DEV. =   3.3 DEGREES          
REMARK 500  9 ARG A  90   NE  -  CZ  -  NH1 ANGL. DEV. =   3.2 DEGREES          
REMARK 500  9 ARG A  95   NH1 -  CZ  -  NH2 ANGL. DEV. =  -7.5 DEGREES          
REMARK 500  9 ARG A  95   NE  -  CZ  -  NH1 ANGL. DEV. =   4.8 DEGREES          
REMARK 500  9 TYR A 122   CB  -  CG  -  CD2 ANGL. DEV. =  -4.0 DEGREES          
REMARK 500 10 ARG A  40   NE  -  CZ  -  NH1 ANGL. DEV. =   4.7 DEGREES          
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      55 ANGLE DEVIATIONS.                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500  1 VAL A  23       72.94    -69.01                                   
REMARK 500  1 THR A  25     -120.77   -101.94                                   
REMARK 500  1 HIS A  38       37.77    -64.20                                   
REMARK 500  1 CYS A  41       71.76     49.13                                   
REMARK 500  1 LYS A  43      171.78     62.75                                   
REMARK 500  1 ALA A  48      173.50     54.55                                   
REMARK 500  1 THR A  61     -177.68    152.28                                   
REMARK 500  1 ASN A  69       40.50   -156.78                                   
REMARK 500  1 ASP A  70      -26.60     62.85                                   
REMARK 500  1 ASN A  72      -45.20   -173.86                                   
REMARK 500  1 TYR A  73       23.72     43.57                                   
REMARK 500  1 ALA A  75      -75.24     64.06                                   
REMARK 500  1 GLU A  76       99.17     33.81                                   
REMARK 500  1 LYS A  85      -73.13   -126.53                                   
REMARK 500  1 ASN A  86       33.50    -72.93                                   
REMARK 500  1 ARG A  99       42.41    -73.11                                   
REMARK 500  1 SER A 100      157.21     73.04                                   
REMARK 500  1 ARG A 124      125.49     96.78                                   
REMARK 500  1 ILE A 126      122.89     38.53                                   
REMARK 500  1 ASP A 131      -70.50   -101.37                                   
REMARK 500  1 ARG A 134      145.26   -174.94                                   
REMARK 500  2 VAL A  23       73.53    -64.89                                   
REMARK 500  2 THR A  25     -105.33   -133.06                                   
REMARK 500  2 HIS A  38       47.69    -67.51                                   
REMARK 500  2 CYS A  41       95.84     62.80                                   
REMARK 500  2 LYS A  43      177.33     74.14                                   
REMARK 500  2 LEU A  45       87.16     51.22                                   
REMARK 500  2 PRO A  46       61.62    -66.90                                   
REMARK 500  2 ASN A  69      -61.90   -121.74                                   
REMARK 500  2 GLU A  71      -26.94     64.82                                   
REMARK 500  2 ASN A  72       49.33   -102.35                                   
REMARK 500  2 SER A  74       72.75     14.92                                   
REMARK 500  2 ASN A  79       -9.03     79.71                                   
REMARK 500  2 ALA A  80       20.82    -68.91                                   
REMARK 500  2 LYS A  85      -72.05    -96.00                                   
REMARK 500  2 PHE A  91     -139.69     51.33                                   
REMARK 500  2 LEU A  94      118.56   -160.88                                   
REMARK 500  2 SER A 100     -177.45     58.71                                   
REMARK 500  2 HIS A 123       62.73    -57.96                                   
REMARK 500  2 ALA A 125     -103.89   -164.83                                   
REMARK 500  2 ILE A 126     -158.85     43.15                                   
REMARK 500  3 VAL A  23       71.50    -69.77                                   
REMARK 500  3 ARG A  24      172.11    -53.97                                   
REMARK 500  3 THR A  25     -135.10   -108.28                                   
REMARK 500  3 PRO A  36       48.06    -66.30                                   
REMARK 500  3 THR A  37       16.71    -65.02                                   
REMARK 500  3 HIS A  38       69.45    -55.21                                   
REMARK 500  3 CYS A  41       84.21     59.04                                   
REMARK 500  3 LYS A  43      160.29     71.77                                   
REMARK 500  3 ALA A  48      175.72     66.09                                   
REMARK 500  3 ASP A  56     -176.37    -68.23                                   
REMARK 500  3 ASP A  59       79.94     29.23                                   
REMARK 500  3 GLU A  71      -11.94   -144.03                                   
REMARK 500  3 ASN A  72      151.78     84.37                                   
REMARK 500  3 TYR A  73       43.23     33.26                                   
REMARK 500  3 GLU A  76      172.13    -58.23                                   
REMARK 500  3 ALA A  80        7.11    -62.92                                   
REMARK 500  3 LYS A  85      -96.82   -110.89                                   
REMARK 500  3 PHE A  91     -138.63     57.38                                   
REMARK 500  3 ASP A  93       67.12    175.12                                   
REMARK 500  3 SER A 100       92.68    -67.59                                   
REMARK 500  3 HIS A 123      170.95     74.34                                   
REMARK 500  3 ILE A 126       86.87    -64.82                                   
REMARK 500  3 PRO A 133       77.51    -69.80                                   
REMARK 500  3 ARG A 134       96.91    145.38                                   
REMARK 500  4 VAL A  23       74.84    -69.93                                   
REMARK 500  4 THR A  25     -154.53    -86.43                                   
REMARK 500  4 ASP A  26      -18.37    -47.51                                   
REMARK 500  4 HIS A  38       77.51   -113.39                                   
REMARK 500  4 CYS A  41     -107.54      9.43                                   
REMARK 500  4 ASN A  42      -57.05    171.32                                   
REMARK 500  4 LYS A  43       -1.25     68.97                                   
REMARK 500  4 THR A  44      103.02    142.60                                   
REMARK 500  4 PRO A  46       35.96    -75.55                                   
REMARK 500  4 ILE A  47      -71.40    -35.48                                   
REMARK 500  4 ALA A  48      -30.76   -163.47                                   
REMARK 500  4 ASN A  69      -15.42    170.74                                   
REMARK 500  4 GLU A  71       30.00    148.26                                   
REMARK 500  4 ASN A  72     -102.36   -156.84                                   
REMARK 500  4 SER A  74      111.90   -168.63                                   
REMARK 500  4 LYS A  85      -80.20   -112.13                                   
REMARK 500  4 GLN A  87       22.60   -170.02                                   
REMARK 500  4 ASP A  93      -20.32     60.48                                   
REMARK 500  4 ARG A  99       84.12    132.27                                   
REMARK 500  4 ARG A 102      150.23    169.64                                   
REMARK 500  4 LYS A 104       92.34    -68.53                                   
REMARK 500  4 THR A 107       77.45   -101.65                                   
REMARK 500  4 PHE A 113        3.64    -58.19                                   
REMARK 500  4 HIS A 123       64.00   -152.61                                   
REMARK 500  4 ALA A 125       82.26     51.60                                   
REMARK 500  4 ILE A 126      -89.42   -118.46                                   
REMARK 500  4 ARG A 134      -20.93    132.02                                   
REMARK 500  5 VAL A  23       72.60    -68.27                                   
REMARK 500  5 THR A  25     -136.03    -81.92                                   
REMARK 500  5 ASP A  26      -17.20    -48.66                                   
REMARK 500  5 PRO A  28       30.01    -70.32                                   
REMARK 500  5 ASN A  29      -20.48    132.81                                   
REMARK 500  5 THR A  37       45.30     38.39                                   
REMARK 500  5 HIS A  38       94.15     44.42                                   
REMARK 500  5 ASN A  42      -46.94    -21.11                                   
REMARK 500  5 LYS A  43      -29.88     53.81                                   
REMARK 500  5 THR A  44       83.08    141.27                                   
REMARK 500  5 PRO A  46       37.40    -69.13                                   
REMARK 500  5 ALA A  48     -174.00     54.67                                   
REMARK 500  5 THR A  61       99.71    -52.14                                   
REMARK 500  5 ASN A  69      109.35     72.94                                   
REMARK 500  5 ASN A  72     -108.30    -82.37                                   
REMARK 500  5 TYR A  73       70.79   -172.64                                   
REMARK 500  5 SER A  74       89.75     63.35                                   
REMARK 500  5 GLU A  76       96.72    161.09                                   
REMARK 500  5 ASN A  79        4.07     84.16                                   
REMARK 500  5 ALA A  80        9.85    -64.07                                   
REMARK 500  5 LYS A  85     -117.03    -79.48                                   
REMARK 500  5 ASN A  86       -8.14    -58.70                                   
REMARK 500  5 GLN A  87        6.82    135.69                                   
REMARK 500  5 PHE A  91      -78.90     45.93                                   
REMARK 500  5 ASN A  92      160.99     44.88                                   
REMARK 500  5 LEU A  94      120.18     40.82                                   
REMARK 500  5 ARG A  99       48.94   -146.90                                   
REMARK 500  5 SER A 100      -81.49    144.53                                   
REMARK 500  5 ARG A 124      -99.94   -136.48                                   
REMARK 500  6 VAL A  23       71.99    -68.28                                   
REMARK 500  6 THR A  25      -73.67   -100.68                                   
REMARK 500  6 SER A  27       36.38     75.19                                   
REMARK 500  6 PRO A  28       37.37    -69.74                                   
REMARK 500  6 HIS A  38       56.37     31.57                                   
REMARK 500  6 ILE A  47     -114.80   -141.34                                   
REMARK 500  6 ASP A  59       97.11     69.59                                   
REMARK 500  6 THR A  61     -172.17     95.13                                   
REMARK 500  6 ASN A  69      -33.01     57.51                                   
REMARK 500  6 GLU A  71      -67.08   -120.78                                   
REMARK 500  6 ASN A  72      -85.23   -145.47                                   
REMARK 500  6 TYR A  73       10.73   -168.24                                   
REMARK 500  6 SER A  74      -72.54    -59.51                                   
REMARK 500  6 ALA A  75     -156.68     46.75                                   
REMARK 500  6 GLU A  76      148.44     65.11                                   
REMARK 500  6 ALA A  80        2.63    -65.51                                   
REMARK 500  6 LYS A  85      -80.13   -126.83                                   
REMARK 500  6 ASN A  86       45.71    -80.65                                   
REMARK 500  6 PHE A  91      178.97    108.04                                   
REMARK 500  6 ASN A  92     -157.06    -82.32                                   
REMARK 500  6 VAL A  97       70.69     60.40                                   
REMARK 500  6 ARG A  99      -16.67     73.05                                   
REMARK 500  6 SER A 100       -5.52     30.78                                   
REMARK 500  6 ARG A 102      172.34     90.70                                   
REMARK 500  6 THR A 107       52.05   -148.65                                   
REMARK 500  6 THR A 109      -77.61    172.28                                   
REMARK 500  6 HIS A 123       57.19    -97.00                                   
REMARK 500  6 ARG A 124      -61.73   -133.19                                   
REMARK 500  6 ILE A 126      -86.60     11.94                                   
REMARK 500  6 ASP A 131      -70.56    -99.10                                   
REMARK 500  6 ARG A 134      -47.42   -140.80                                   
REMARK 500  7 THR A  25     -101.10   -129.52                                   
REMARK 500  7 PRO A  28      -19.51    -46.26                                   
REMARK 500  7 THR A  37      -80.77    -77.64                                   
REMARK 500  7 HIS A  38       78.21     44.37                                   
REMARK 500  7 ASN A  42        8.65     56.28                                   
REMARK 500  7 ALA A  48      162.09     68.51                                   
REMARK 500  7 ASP A  56      169.38     56.80                                   
REMARK 500  7 VAL A  57      -43.86   -149.54                                   
REMARK 500  7 ASP A  59     -122.19     16.75                                   
REMARK 500  7 GLU A  71      -25.98   -148.41                                   
REMARK 500  7 SER A  74       78.79     63.08                                   
REMARK 500  7 GLU A  76      143.86    173.22                                   
REMARK 500  7 ASN A  79       -2.20     88.84                                   
REMARK 500  7 ALA A  80       34.12    -76.01                                   
REMARK 500  7 MET A  84     -127.86     86.54                                   
REMARK 500  7 LYS A  85      -25.65     70.08                                   
REMARK 500  7 GLN A  87      -47.54   -148.41                                   
REMARK 500  7 PHE A  91     -167.60     61.45                                   
REMARK 500  7 ASP A  93       74.46    121.00                                   
REMARK 500  7 ARG A 102      164.18     69.01                                   
REMARK 500  7 PRO A 117       94.64    -51.91                                   
REMARK 500  7 HIS A 123     -166.45   -167.17                                   
REMARK 500  7 ARG A 124      -33.62     66.10                                   
REMARK 500  7 ALA A 125      -74.97    -28.99                                   
REMARK 500  7 PRO A 133      -75.62    -73.85                                   
REMARK 500  7 ARG A 134      -71.54   -135.09                                   
REMARK 500  8 VAL A  23       71.13    -67.63                                   
REMARK 500  8 ASP A  26       21.19    -69.37                                   
REMARK 500  8 ASN A  29       72.08   -174.19                                   
REMARK 500  8 CYS A  41      113.33     95.62                                   
REMARK 500  8 ASN A  42      -71.47    -57.10                                   
REMARK 500  8 THR A  44       -8.22     91.47                                   
REMARK 500  8 PRO A  46       29.33    -73.37                                   
REMARK 500  8 ASP A  56     -168.74     62.55                                   
REMARK 500  8 VAL A  57       73.08    169.52                                   
REMARK 500  8 ASP A  59       93.40     30.09                                   
REMARK 500  8 ASN A  69      -87.84   -144.75                                   
REMARK 500  8 ASN A  72      -79.95   -162.61                                   
REMARK 500  8 TYR A  73      108.30    136.33                                   
REMARK 500  8 SER A  74      -77.79   -124.42                                   
REMARK 500  8 ALA A  75       -2.16     58.76                                   
REMARK 500  8 GLU A  76       61.42    -63.31                                   
REMARK 500  8 ASN A  79        2.53     95.25                                   
REMARK 500  8 ALA A  80       -6.15    -46.77                                   
REMARK 500  8 LYS A  85      -87.01   -118.05                                   
REMARK 500  8 ASN A  86       43.83    -75.69                                   
REMARK 500  8 PHE A  91      -86.56     61.11                                   
REMARK 500  8 ASN A  92      -66.72   -151.27                                   
REMARK 500  8 ASP A  93      -21.25     69.13                                   
REMARK 500  8 VAL A  97       41.03     38.67                                   
REMARK 500  8 ARG A  99       -5.64    117.88                                   
REMARK 500  8 ARG A 102       89.73   -177.17                                   
REMARK 500  8 ARG A 124      176.51     74.46                                   
REMARK 500  8 ASP A 131      -69.02    -99.97                                   
REMARK 500  8 ARG A 134       86.73    145.45                                   
REMARK 500  9 VAL A  23       74.84    -65.17                                   
REMARK 500  9 ASP A  26      -58.91    118.01                                   
REMARK 500  9 SER A  27      -53.68    133.47                                   
REMARK 500  9 PRO A  28       90.99    -62.43                                   
REMARK 500  9 ASN A  29       58.30     36.14                                   
REMARK 500  9 PRO A  36       96.81    -50.78                                   
REMARK 500  9 THR A  37      -76.13   -102.57                                   
REMARK 500  9 CYS A  41      -70.56    -81.02                                   
REMARK 500  9 LYS A  43       -7.13     71.37                                   
REMARK 500  9 PRO A  46       41.83    -73.00                                   
REMARK 500  9 ALA A  48      173.79     70.13                                   
REMARK 500  9 PRO A  58     -150.76    -70.71                                   
REMARK 500  9 ASP A  59      101.81    -50.99                                   
REMARK 500  9 ASN A  69      -52.61   -155.13                                   
REMARK 500  9 ASP A  70      -48.25   -149.19                                   
REMARK 500  9 GLU A  71      -10.24   -147.29                                   
REMARK 500  9 ASN A  72      -15.57    -48.43                                   
REMARK 500  9 TYR A  73        2.65     53.85                                   
REMARK 500  9 SER A  74      -99.46    -92.33                                   
REMARK 500  9 ALA A  75      -65.51     57.07                                   
REMARK 500  9 LYS A  85     -101.47   -112.87                                   
REMARK 500  9 ASN A  86       45.35    -79.57                                   
REMARK 500  9 PHE A  91     -151.07    130.87                                   
REMARK 500  9 ASP A  93       44.23    108.02                                   
REMARK 500  9 VAL A  97       73.48     71.13                                   
REMARK 500  9 SER A 100     -168.50    -70.93                                   
REMARK 500  9 THR A 107       51.17   -143.36                                   
REMARK 500  9 THR A 109     -116.26    152.38                                   
REMARK 500  9 HIS A 123       68.66   -106.82                                   
REMARK 500  9 ARG A 124     -179.70    173.41                                   
REMARK 500  9 ALA A 125      -58.14     61.27                                   
REMARK 500  9 ILE A 126      -62.12     67.31                                   
REMARK 500  9 ARG A 134      106.05     82.85                                   
REMARK 500 10 VAL A  23       73.18    -64.08                                   
REMARK 500 10 THR A  25     -167.28    -76.47                                   
REMARK 500 10 ASP A  26       12.91    -66.24                                   
REMARK 500 10 HIS A  38       40.44     37.26                                   
REMARK 500 10 CYS A  41      101.54     51.05                                   
REMARK 500 10 ASN A  42      -72.59    -47.17                                   
REMARK 500 10 LYS A  43      118.37     22.16                                   
REMARK 500 10 THR A  44       77.21     68.04                                   
REMARK 500 10 ILE A  47      -69.27   -134.64                                   
REMARK 500 10 ALA A  48       90.03     31.23                                   
REMARK 500 10 VAL A  57      157.81     78.54                                   
REMARK 500 10 THR A  61      170.95    154.22                                   
REMARK 500 10 ASN A  69      -72.42    107.33                                   
REMARK 500 10 ASN A  72      -79.78     94.66                                   
REMARK 500 10 TYR A  73       65.95   -157.92                                   
REMARK 500 10 ALA A  80        1.25    -65.24                                   
REMARK 500 10 LYS A  85      -84.24   -107.84                                   
REMARK 500 10 GLN A  87       19.98     56.94                                   
REMARK 500 10 PHE A  91     -111.43    147.44                                   
REMARK 500 10 ASN A  92       41.31    177.30                                   
REMARK 500 10 ARG A  99        6.13   -165.93                                   
REMARK 500 10 ARG A 124      -52.10   -152.70                                   
REMARK 500 10 ALA A 125       70.85   -155.31                                   
REMARK 500 10 ILE A 126      -14.17    -47.14                                   
REMARK 500 10 PRO A 133       66.53    -69.73                                   
REMARK 500 10 ARG A 134        8.25    -65.22                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500  2 ARG A  24         0.09    SIDE_CHAIN                              
REMARK 500  2 TYR A  73         0.08    SIDE_CHAIN                              
REMARK 500  8 TYR A 122         0.07    SIDE_CHAIN                              
REMARK 500  9 ARG A  78         0.07    SIDE_CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
DBREF  1CO1 A   21   135  UNP    Q01196   RUNX1_HUMAN     61    175             
SEQRES   1 A  115  GLU LEU VAL ARG THR ASP SER PRO ASN PHE LEU CYS SER          
SEQRES   2 A  115  VAL LEU PRO THR HIS TRP ARG CYS ASN LYS THR LEU PRO          
SEQRES   3 A  115  ILE ALA PHE LYS VAL VAL ALA LEU GLY ASP VAL PRO ASP          
SEQRES   4 A  115  GLY THR LEU VAL THR VAL MET ALA GLY ASN ASP GLU ASN          
SEQRES   5 A  115  TYR SER ALA GLU LEU ARG ASN ALA THR ALA ALA MET LYS          
SEQRES   6 A  115  ASN GLN VAL ALA ARG PHE ASN ASP LEU ARG PHE VAL GLY          
SEQRES   7 A  115  ARG SER GLY ARG GLY LYS SER PHE THR LEU THR ILE THR          
SEQRES   8 A  115  VAL PHE THR ASN PRO PRO GLN VAL ALA THR TYR HIS ARG          
SEQRES   9 A  115  ALA ILE LYS ILE THR VAL ASP GLY PRO ARG GLU                  
SHEET    1   A 3 PHE A  30  SER A  33  0                                        
SHEET    2   A 3 PHE A  49  ALA A  53 -1  N  VAL A  52   O  LEU A  31           
SHEET    3   A 3 VAL A  88  PHE A  91 -1  N  PHE A  91   O  PHE A  49           
SHEET    1   B 4 THR A  81  MET A  84  0                                        
SHEET    2   B 4 THR A  61  GLY A  68 -1  N  VAL A  63   O  ALA A  82           
SHEET    3   B 4 SER A 105  THR A 111 -1  N  THR A 111   O  LEU A  62           
SHEET    4   B 4 VAL A 119  THR A 121 -1  N  ALA A 120   O  ILE A 110           
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
MODEL        1                                                                  
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system