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Entry: 1RML
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HEADER    GROWTH FACTOR                           21-MAY-98   1RML              
TITLE     NMR STUDY OF ACID FIBROBLAST GROWTH FACTOR BOUND TO 1,3,6-            
TITLE    2 NAPHTHALENE TRISULPHONATE, 26 STRUCTURES                             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: ACIDIC FIBROBLAST GROWTH FACTOR;                           
COMPND   3 CHAIN: A;                                                            
COMPND   4 FRAGMENT: RESIDUES 23 - 154;                                         
COMPND   5 SYNONYM: HEPARIN-BINDING GROWTH FACTOR 1;                            
COMPND   6 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   7 EXPRESSION_SYSTEM_PLASMID: PMG47                                     
KEYWDS    GROWTH FACTOR, FIBROBLAST GROWTH FACTOR, ANTITUMORAL,                 
KEYWDS   2 NAPHTHALENE                                                          
EXPDTA    SOLUTION NMR                                                          
NUMMDL    26                                                                    
AUTHOR    R.M.LOZANO,M.A.JIMENEZ,J.SANTORO,M.RICO,G.GIMENEZ-GALLEGO             
REVDAT   3   24-FEB-09 1RML    1       VERSN                                    
REVDAT   2   01-APR-03 1RML    1       JRNL                                     
REVDAT   1   11-NOV-98 1RML    0                                                
JRNL        AUTH   R.M.LOZANO,M.JIMENEZ,J.SANTORO,M.RICO,                       
JRNL        AUTH 2 G.GIMENEZ-GALLEGO                                            
JRNL        TITL   SOLUTION STRUCTURE OF ACIDIC FIBROBLAST GROWTH               
JRNL        TITL 2 FACTOR BOUND TO 1,3, 6-NAPHTHALENETRISULFONATE: A            
JRNL        TITL 3 MINIMAL MODEL FOR THE ANTI-TUMORAL ACTION OF                 
JRNL        TITL 4 SURAMINS AND SURADISTAS.                                     
JRNL        REF    J.MOL.BIOL.                   V. 281   899 1998              
JRNL        REFN                   ISSN 0022-2836                               
JRNL        PMID   9719643                                                      
JRNL        DOI    10.1006/JMBI.1998.1977                                       
REMARK   1                                                                      
REMARK   1 REFERENCE 1                                                          
REMARK   1  AUTH   A.PINEDA-LUCENA,M.A.JIMENEZ,R.M.LOZANO,J.L.NIETO,            
REMARK   1  AUTH 2 J.SANTORO,M.RICO,G.GIMENEZ-GALLEGO                           
REMARK   1  TITL   THREE-DIMENSIONAL STRUCTURE OF ACIDIC FIBROBLAST             
REMARK   1  TITL 2 GROWTH FACTOR IN SOLUTION: EFFECTS OF BINDING TO A           
REMARK   1  TITL 3 HEPARIN FUNCTIONAL ANALOG                                    
REMARK   1  REF    J.MOL.BIOL.                   V. 264   162 1996              
REMARK   1  REFN                   ISSN 0022-2836                               
REMARK   1 REFERENCE 2                                                          
REMARK   1  AUTH   A.PINEDA-LUCENA,M.A.JIMENEZ,J.L.NIETO,J.SANTORO,             
REMARK   1  AUTH 2 M.RICO,G.GIMENEZ-GALLEGO                                     
REMARK   1  TITL   1H-NMR ASSIGNMENT AND SOLUTION STRUCTURE OF HUMAN            
REMARK   1  TITL 2 ACIDIC FIBROBLAST GROWTH FACTOR ACTIVATED BY                 
REMARK   1  TITL 3 INOSITOL HEXASULFATE                                         
REMARK   1  REF    J.MOL.BIOL.                   V. 242    81 1994              
REMARK   1  REFN                   ISSN 0022-2836                               
REMARK   1 REFERENCE 3                                                          
REMARK   1  AUTH   A.PINEDA-LUCENA,M.A.JIMENEZ,J.L.NIETO,J.SANTORO,             
REMARK   1  AUTH 2 M.RICO,G.GIMENEZ-GALLEGO                                     
REMARK   1  TITL   ERRATUM. 1H-NMR ASSIGNMENT AND SOLUTION STRUCTURE            
REMARK   1  TITL 2 OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR ACTIVATED           
REMARK   1  TITL 3 BY INOSITOL HEXASULFATE                                      
REMARK   1  REF    J.MOL.BIOL.                   V. 244   251 1994              
REMARK   1  REFN                   ISSN 0022-2836                               
REMARK   2                                                                      
REMARK   2 RESOLUTION. NOT APPLICABLE.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : DIANA                                                
REMARK   3   AUTHORS     : GUNTERT, BRAUN                                       
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 1RML COMPLIES WITH FORMAT V. 3.15, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY BNL.                                
REMARK 210                                                                      
REMARK 210 EXPERIMENTAL DETAILS                                                 
REMARK 210  EXPERIMENT TYPE                : NMR                                
REMARK 210  TEMPERATURE           (KELVIN) : 298                                
REMARK 210  PH                             : 6.0                                
REMARK 210  IONIC STRENGTH                 : NULL                               
REMARK 210  PRESSURE                       : NULL                               
REMARK 210  SAMPLE CONTENTS                : WATER                              
REMARK 210                                                                      
REMARK 210  NMR EXPERIMENTS CONDUCTED      : COSY, TOCSY, NOESY                 
REMARK 210  SPECTROMETER FIELD STRENGTH    : 600 MHZ                            
REMARK 210  SPECTROMETER MODEL             : AMX-600                            
REMARK 210  SPECTROMETER MANUFACTURER      : BRUKER                             
REMARK 210                                                                      
REMARK 210  STRUCTURE DETERMINATION.                                            
REMARK 210   SOFTWARE USED                 : DIANA                              
REMARK 210   METHOD USED                   : VARIABLE TARGET FUNCTION           
REMARK 210                                                                      
REMARK 210 CONFORMERS, NUMBER CALCULATED   : 26                                 
REMARK 210 CONFORMERS, NUMBER SUBMITTED    : 26                                 
REMARK 210 CONFORMERS, SELECTION CRITERIA  : NULL                               
REMARK 210                                                                      
REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : NULL                
REMARK 210                                                                      
REMARK 210 REMARK: NULL                                                         
REMARK 215                                                                      
REMARK 215 NMR STUDY                                                            
REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION           
REMARK 215 NMR DATA.  PROTEIN DATA BANK CONVENTIONS REQUIRE THAT                
REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON              
REMARK 215 THESE RECORDS ARE MEANINGLESS.                                       
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (RES=RESIDUE NAME; C=CHAIN IDENTIFIER;                   
REMARK 465 SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                            
REMARK 465   MODELS 1-26                                                        
REMARK 465     RES C SSSEQI                                                     
REMARK 465     MET A     0                                                      
REMARK 465     ALA A     1                                                      
REMARK 465     GLU A     2                                                      
REMARK 465     GLY A     3                                                      
REMARK 465     GLU A     4                                                      
REMARK 465     ILE A     5                                                      
REMARK 465     THR A     6                                                      
REMARK 465     THR A     7                                                      
REMARK 465     PHE A     8                                                      
REMARK 465     THR A     9                                                      
REMARK 465     ALA A    10                                                      
REMARK 465     LEU A    11                                                      
REMARK 465     THR A    12                                                      
REMARK 465     GLU A    13                                                      
REMARK 465     LYS A    14                                                      
REMARK 465     PHE A    15                                                      
REMARK 465     ASN A    16                                                      
REMARK 465     LEU A    17                                                      
REMARK 465     PRO A    18                                                      
REMARK 465     PRO A    19                                                      
REMARK 465     GLY A    20                                                      
REMARK 465     ASN A    21                                                      
REMARK 465     TYR A    22                                                      
REMARK 465     LYS A    23                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500  1 LYS A  26      138.27   -172.82                                   
REMARK 500  1 SER A  31      -94.71    -54.64                                   
REMARK 500  1 LEU A  37      150.09    -37.61                                   
REMARK 500  1 ASP A  46     -171.21    172.41                                   
REMARK 500  1 SER A  52       69.35    179.90                                   
REMARK 500  1 HIS A  55      103.17   -168.90                                   
REMARK 500  1 GLN A  59      142.79   -176.93                                   
REMARK 500  1 SER A  61       55.34   -144.87                                   
REMARK 500  1 SER A  64      136.71    159.60                                   
REMARK 500  1 GLU A  67      101.82   -163.51                                   
REMARK 500  1 SER A  72       71.67    -66.78                                   
REMARK 500  1 THR A  73      109.96    -38.13                                   
REMARK 500  1 GLU A  74      -63.65    168.56                                   
REMARK 500  1 LEU A  79      106.75    -59.84                                   
REMARK 500  1 ASN A  94     -153.18   -157.07                                   
REMARK 500  1 GLU A  95       69.42    -66.68                                   
REMARK 500  1 GLU A  96      -47.90   -179.11                                   
REMARK 500  1 LEU A  98      170.84    -52.31                                   
REMARK 500  1 LEU A 100      101.29    -41.85                                   
REMARK 500  1 ARG A 102      -95.97   -142.80                                   
REMARK 500  1 LEU A 103      119.12   -175.87                                   
REMARK 500  1 GLU A 105     -103.03   -120.66                                   
REMARK 500  1 ASN A 106       47.14   -167.36                                   
REMARK 500  1 HIS A 107      -64.83   -172.04                                   
REMARK 500  1 TYR A 108     -156.60    -59.72                                   
REMARK 500  1 ASN A 109       77.27   -163.69                                   
REMARK 500  1 ILE A 112      114.14   -160.68                                   
REMARK 500  1 SER A 113       95.13    -37.62                                   
REMARK 500  1 HIS A 116       55.71   -153.87                                   
REMARK 500  1 PHE A 122      179.53    -55.96                                   
REMARK 500  1 LYS A 126      128.34    -36.46                                   
REMARK 500  1 LYS A 127       59.44    -67.85                                   
REMARK 500  1 ASN A 128      -44.46   -150.05                                   
REMARK 500  1 SER A 130      114.72    169.92                                   
REMARK 500  1 CYS A 131     -178.97    -58.41                                   
REMARK 500  1 LYS A 132     -167.55   -111.49                                   
REMARK 500  1 ARG A 133      110.48   -170.12                                   
REMARK 500  1 ARG A 136       41.00    169.39                                   
REMARK 500  1 THR A 137       59.09   -148.95                                   
REMARK 500  1 TYR A 139     -177.41    -49.70                                   
REMARK 500  1 GLN A 141      -90.29   -133.89                                   
REMARK 500  1 LYS A 142       60.37   -178.40                                   
REMARK 500  1 LEU A 145       91.63    -52.88                                   
REMARK 500  1 VAL A 151       56.89   -172.22                                   
REMARK 500  1 SER A 152       87.35    -56.75                                   
REMARK 500  2 SER A  31      -90.43    -61.14                                   
REMARK 500  2 LEU A  37      145.95    -38.42                                   
REMARK 500  2 ASP A  46     -159.42   -175.84                                   
REMARK 500  2 ARG A  51      123.00    -34.31                                   
REMARK 500  2 SER A  52       69.46    179.75                                   
REMARK 500  2 HIS A  55      102.55   -166.28                                   
REMARK 500  2 SER A  61       49.83   -145.57                                   
REMARK 500  2 ALA A  62      126.51    -37.95                                   
REMARK 500  2 SER A  64      176.73    166.23                                   
REMARK 500  2 GLU A  67      109.71   -172.20                                   
REMARK 500  2 THR A  73       90.84    -49.67                                   
REMARK 500  2 GLU A  74      -70.40   -171.02                                   
REMARK 500  2 LEU A  87      128.01    -39.34                                   
REMARK 500  2 ASN A  94     -150.84   -164.37                                   
REMARK 500  2 GLU A  95       59.92    -68.54                                   
REMARK 500  2 GLU A  96      -41.44   -167.83                                   
REMARK 500  2 LEU A 100      101.91    -41.94                                   
REMARK 500  2 ARG A 102      -98.14   -140.49                                   
REMARK 500  2 LEU A 103      121.12   -178.37                                   
REMARK 500  2 GLU A 104      -61.56    -96.93                                   
REMARK 500  2 GLU A 105     -109.36   -103.13                                   
REMARK 500  2 ASN A 106       45.59   -161.63                                   
REMARK 500  2 HIS A 107      -60.19   -167.69                                   
REMARK 500  2 TYR A 108     -154.17    -66.74                                   
REMARK 500  2 ASN A 109       86.80   -169.93                                   
REMARK 500  2 SER A 113       97.81    -47.43                                   
REMARK 500  2 HIS A 116       66.75   -172.93                                   
REMARK 500  2 VAL A 123       63.84   -111.98                                   
REMARK 500  2 LYS A 126      131.77    -35.98                                   
REMARK 500  2 LYS A 127       58.50    -69.34                                   
REMARK 500  2 ASN A 128      -45.46   -148.36                                   
REMARK 500  2 SER A 130      133.58    175.27                                   
REMARK 500  2 CYS A 131      170.78    -54.43                                   
REMARK 500  2 PRO A 135       49.63    -75.07                                   
REMARK 500  2 ARG A 136       38.60    169.10                                   
REMARK 500  2 TYR A 139     -179.63    -57.37                                   
REMARK 500  2 GLN A 141      -85.36   -129.19                                   
REMARK 500  2 LYS A 142       37.66    179.57                                   
REMARK 500  2 LEU A 145       91.40    -53.06                                   
REMARK 500  2 VAL A 151       51.79   -165.83                                   
REMARK 500  2 SER A 152       82.37    -60.86                                   
REMARK 500  3 LYS A  26      146.27   -174.55                                   
REMARK 500  3 SER A  31      -96.90    -44.47                                   
REMARK 500  3 LEU A  37      162.05    -44.72                                   
REMARK 500  3 ASP A  46     -169.97    171.46                                   
REMARK 500  3 ARG A  51      118.63    -30.93                                   
REMARK 500  3 SER A  52       69.48    179.45                                   
REMARK 500  3 HIS A  55      104.52   -169.98                                   
REMARK 500  3 SER A  61       54.99   -145.50                                   
REMARK 500  3 ALA A  62      126.60    -39.35                                   
REMARK 500  3 SER A  64      135.90    158.76                                   
REMARK 500  3 SER A  72       88.31    -65.48                                   
REMARK 500  3 THR A  73      100.14    -59.62                                   
REMARK 500  3 GLU A  74      -52.26   -176.82                                   
REMARK 500  3 ASP A  82      171.42    -46.59                                   
REMARK 500  3 ASN A  94     -151.43   -153.02                                   
REMARK 500  3 GLU A  95       69.35    -65.33                                   
REMARK 500  3 GLU A  96      -39.49    179.99                                   
REMARK 500  3 LEU A  98      175.37    -53.21                                   
REMARK 500  3 LEU A 103       93.53    -27.34                                   
REMARK 500  3 GLU A 105     -105.11   -130.23                                   
REMARK 500  3 HIS A 107      -67.44    179.99                                   
REMARK 500  3 TYR A 108      102.40    -53.58                                   
REMARK 500  3 THR A 110       97.36    -48.39                                   
REMARK 500  3 SER A 113       98.11    -35.44                                   
REMARK 500  3 HIS A 116       39.27   -152.94                                   
REMARK 500  3 TRP A 121       82.45    -62.94                                   
REMARK 500  3 PHE A 122     -171.26    -60.73                                   
REMARK 500  3 LYS A 126      114.81    -20.89                                   
REMARK 500  3 LYS A 127       61.05    -63.26                                   
REMARK 500  3 ASN A 128      -41.12   -150.56                                   
REMARK 500  3 SER A 130      135.41    169.72                                   
REMARK 500  3 ARG A 136       39.89    170.40                                   
REMARK 500  3 TYR A 139     -158.65    -56.11                                   
REMARK 500  3 LYS A 142      -24.62    -35.39                                   
REMARK 500  3 VAL A 151       38.05   -177.22                                   
REMARK 500  3 SER A 152       84.43    -60.70                                   
REMARK 500  3 SER A 153       81.41   -152.31                                   
REMARK 500  4 LYS A  26      132.99   -173.99                                   
REMARK 500  4 SER A  31      -94.46    -45.09                                   
REMARK 500  4 LEU A  37      133.12    -37.44                                   
REMARK 500  4 ASP A  46     -172.56    169.85                                   
REMARK 500  4 ARG A  49      -34.29    -35.92                                   
REMARK 500  4 ARG A  51       94.71    -24.68                                   
REMARK 500  4 SER A  61       50.98   -146.93                                   
REMARK 500  4 ALA A  62      124.90    -38.72                                   
REMARK 500  4 SER A  64      178.74    173.79                                   
REMARK 500  4 GLU A  67      121.04   -175.20                                   
REMARK 500  4 THR A  73       95.28    -37.37                                   
REMARK 500  4 GLU A  74      -51.70    173.05                                   
REMARK 500  4 THR A  75     -110.92    -97.83                                   
REMARK 500  4 LEU A  87      136.91    -39.72                                   
REMARK 500  4 ASN A  94     -153.68   -161.11                                   
REMARK 500  4 GLU A  95       67.82    -66.98                                   
REMARK 500  4 GLU A  96      -58.02   -175.08                                   
REMARK 500  4 LEU A 100       96.72    -53.21                                   
REMARK 500  4 ARG A 102       93.84    179.68                                   
REMARK 500  4 LEU A 103       97.17    -31.04                                   
REMARK 500  4 GLU A 105     -113.35   -101.34                                   
REMARK 500  4 ASN A 106       43.26   -142.10                                   
REMARK 500  4 HIS A 107      -69.82   -175.00                                   
REMARK 500  4 TYR A 108      176.89    -47.20                                   
REMARK 500  4 SER A 113       99.98    -44.14                                   
REMARK 500  4 HIS A 116       62.25   -174.55                                   
REMARK 500  4 LYS A 126      128.93    -33.65                                   
REMARK 500  4 LYS A 127       58.87    -67.09                                   
REMARK 500  4 ASN A 128      -44.54   -149.14                                   
REMARK 500  4 SER A 130      128.53    169.84                                   
REMARK 500  4 CYS A 131     -177.26    -53.06                                   
REMARK 500  4 ARG A 136       38.77    169.46                                   
REMARK 500  4 TYR A 139     -174.98    -57.22                                   
REMARK 500  4 GLN A 141      -81.62   -126.48                                   
REMARK 500  4 LYS A 142       40.59    172.43                                   
REMARK 500  4 LEU A 145       92.48    -49.81                                   
REMARK 500  4 VAL A 151       41.44   -169.74                                   
REMARK 500  4 SER A 152       83.28    -61.50                                   
REMARK 500  5 SER A  31      -87.53    -37.21                                   
REMARK 500  5 ASP A  46     -162.20   -176.58                                   
REMARK 500  5 ARG A  51       94.68    -30.88                                   
REMARK 500  5 SER A  52       66.03    178.66                                   
REMARK 500  5 HIS A  55      101.08   -177.15                                   
REMARK 500  5 GLN A  59      120.87   -171.53                                   
REMARK 500  5 SER A  61       57.25   -147.62                                   
REMARK 500  5 ALA A  62      125.12    -38.56                                   
REMARK 500  5 SER A  64      125.73    162.86                                   
REMARK 500  5 GLU A  67      105.98   -169.46                                   
REMARK 500  5 SER A  72       85.34    -56.35                                   
REMARK 500  5 THR A  73      107.13    -58.01                                   
REMARK 500  5 GLU A  74      -41.04    168.67                                   
REMARK 500  5 THR A  75       47.16   -149.47                                   
REMARK 500  5 LEU A  87      138.06    -39.67                                   
REMARK 500  5 ASN A  94     -148.10   -161.91                                   
REMARK 500  5 GLU A  95       63.49    -67.67                                   
REMARK 500  5 GLU A  96      -44.52   -170.60                                   
REMARK 500  5 LEU A  98      173.81    -48.56                                   
REMARK 500  5 LEU A 100       97.75    -51.14                                   
REMARK 500  5 ARG A 102       86.57   -165.01                                   
REMARK 500  5 LEU A 103       97.06    -28.35                                   
REMARK 500  5 GLU A 105     -104.98   -101.18                                   
REMARK 500  5 ASN A 106       34.51   -149.99                                   
REMARK 500  5 HIS A 107      -63.38   -168.58                                   
REMARK 500  5 SER A 113       86.14    -56.91                                   
REMARK 500  5 HIS A 116       65.24   -152.92                                   
REMARK 500  5 TRP A 121       92.26    -54.32                                   
REMARK 500  5 LEU A 125      108.77   -170.27                                   
REMARK 500  5 LYS A 126      128.31    -28.78                                   
REMARK 500  5 LYS A 127       60.31    -65.61                                   
REMARK 500  5 ASN A 128      -43.59   -147.84                                   
REMARK 500  5 SER A 130      142.89    170.25                                   
REMARK 500  5 ARG A 136       39.50    169.24                                   
REMARK 500  5 TYR A 139     -167.70    -58.03                                   
REMARK 500  5 GLN A 141      -89.53   -134.46                                   
REMARK 500  5 LYS A 142       39.23    177.74                                   
REMARK 500  5 LEU A 145       93.03    -59.36                                   
REMARK 500  5 VAL A 151       49.40   -151.54                                   
REMARK 500  5 SER A 153       77.69   -107.75                                   
REMARK 500  6 LEU A  28      170.09    -55.12                                   
REMARK 500  6 TYR A  29      148.79   -172.80                                   
REMARK 500  6 SER A  31      -95.53    -71.58                                   
REMARK 500  6 ASN A  32       90.79    -49.33                                   
REMARK 500  6 LEU A  37      142.36    -34.29                                   
REMARK 500  6 ASP A  46     -172.17    175.80                                   
REMARK 500  6 ARG A  49      -39.32    -38.81                                   
REMARK 500  6 ARG A  51      119.71    -35.23                                   
REMARK 500  6 SER A  52       70.11    179.49                                   
REMARK 500  6 HIS A  55      109.12   -179.50                                   
REMARK 500  6 GLN A  59      143.59   -179.77                                   
REMARK 500  6 SER A  61       53.19   -146.10                                   
REMARK 500  6 ALA A  62      125.99    -39.98                                   
REMARK 500  6 SER A  64      129.18    159.97                                   
REMARK 500  6 THR A  73       95.44    -40.57                                   
REMARK 500  6 GLU A  74      -48.29    176.77                                   
REMARK 500  6 THR A  75       45.85   -142.33                                   
REMARK 500  6 LEU A  87      134.13    -38.57                                   
REMARK 500  6 GLU A  95      -31.91    -37.98                                   
REMARK 500  6 LEU A  98      172.10    -56.84                                   
REMARK 500  6 LEU A 100      100.55    -54.86                                   
REMARK 500  6 ARG A 102       91.11    179.49                                   
REMARK 500  6 LEU A 103       83.91    -60.48                                   
REMARK 500  6 GLU A 105     -100.25   -130.31                                   
REMARK 500  6 ASN A 106       38.82   -143.30                                   
REMARK 500  6 HIS A 107      -65.19   -175.45                                   
REMARK 500  6 THR A 110       96.12    -67.15                                   
REMARK 500  6 SER A 113      105.78    -37.45                                   
REMARK 500  6 HIS A 116       67.01    179.85                                   
REMARK 500  6 PHE A 122     -178.98    -69.51                                   
REMARK 500  6 LYS A 126      125.73    -24.97                                   
REMARK 500  6 LYS A 127       59.14    -67.30                                   
REMARK 500  6 ASN A 128      -46.14   -134.58                                   
REMARK 500  6 SER A 130      125.36    169.15                                   
REMARK 500  6 CYS A 131      163.38    -43.31                                   
REMARK 500  6 ARG A 136       32.86   -172.96                                   
REMARK 500  6 TYR A 139     -167.04    -53.08                                   
REMARK 500  6 VAL A 151       35.18   -173.11                                   
REMARK 500  6 SER A 152       98.04    -39.13                                   
REMARK 500  6 SER A 153       68.71   -173.63                                   
REMARK 500  7 SER A  31      -96.05    -29.74                                   
REMARK 500  7 ASN A  32     -175.55    -52.16                                   
REMARK 500  7 LEU A  37      147.50    -38.46                                   
REMARK 500  7 ASP A  46     -171.34    171.48                                   
REMARK 500  7 ARG A  51      131.44    -24.02                                   
REMARK 500  7 SER A  52       48.55    179.76                                   
REMARK 500  7 HIS A  55      103.54   -169.40                                   
REMARK 500  7 SER A  61       52.97   -142.74                                   
REMARK 500  7 SER A  64      127.06    159.72                                   
REMARK 500  7 VAL A  65      144.21    -38.75                                   
REMARK 500  7 GLU A  67      106.07   -169.61                                   
REMARK 500  7 SER A  72       82.34    -60.42                                   
REMARK 500  7 THR A  73      106.02    -49.01                                   
REMARK 500  7 GLU A  74      -33.05    172.09                                   
REMARK 500  7 THR A  75       37.14   -152.56                                   
REMARK 500  7 LEU A  87      118.45    -39.03                                   
REMARK 500  7 GLU A  95      -30.66    -38.06                                   
REMARK 500  7 LEU A  98      170.16    -46.16                                   
REMARK 500  7 LEU A 100       96.16    -43.15                                   
REMARK 500  7 ARG A 102      -91.25   -140.85                                   
REMARK 500  7 LEU A 103      124.32    178.62                                   
REMARK 500  7 GLU A 105     -139.34   -130.43                                   
REMARK 500  7 HIS A 107      -49.78    179.65                                   
REMARK 500  7 THR A 110      150.42    -37.60                                   
REMARK 500  7 SER A 113      107.24    -36.00                                   
REMARK 500  7 HIS A 116       68.38   -178.80                                   
REMARK 500  7 TRP A 121       97.05    -54.08                                   
REMARK 500  7 LYS A 126      116.65    -24.60                                   
REMARK 500  7 LYS A 127       63.07    -61.76                                   
REMARK 500  7 ASN A 128      -44.68   -134.50                                   
REMARK 500  7 SER A 130      124.80    169.14                                   
REMARK 500  7 ARG A 136       36.57    179.21                                   
REMARK 500  7 TYR A 139     -155.40    -57.55                                   
REMARK 500  7 VAL A 151       27.47   -159.26                                   
REMARK 500  7 SER A 153       66.64   -153.53                                   
REMARK 500  8 LYS A  26      126.78    172.02                                   
REMARK 500  8 SER A  31      -97.36    -65.12                                   
REMARK 500  8 LEU A  37      154.13    -37.01                                   
REMARK 500  8 ASP A  46      178.57    176.37                                   
REMARK 500  8 SER A  52       70.18    179.77                                   
REMARK 500  8 SER A  61       51.34   -143.03                                   
REMARK 500  8 ALA A  62      123.10    -39.82                                   
REMARK 500  8 SER A  64      178.68    170.82                                   
REMARK 500  8 GLU A  67      122.06   -176.58                                   
REMARK 500  8 SER A  72       88.97    -65.96                                   
REMARK 500  8 THR A  73       90.28    -50.83                                   
REMARK 500  8 GLU A  74      -60.65    171.01                                   
REMARK 500  8 THR A  75     -117.70    -79.88                                   
REMARK 500  8 ASP A  82      174.42    -49.86                                   
REMARK 500  8 ASN A  94     -156.27   -154.57                                   
REMARK 500  8 GLU A  95       66.29    -67.97                                   
REMARK 500  8 GLU A  96      -51.45   -176.06                                   
REMARK 500  8 LEU A  98      172.15    -47.34                                   
REMARK 500  8 ARG A 102      -90.03   -147.41                                   
REMARK 500  8 LEU A 103      120.73    178.60                                   
REMARK 500  8 GLU A 105     -104.01   -130.07                                   
REMARK 500  8 ASN A 106       50.77   -158.94                                   
REMARK 500  8 HIS A 107      -62.64    179.84                                   
REMARK 500  8 TYR A 108     -167.45    -54.10                                   
REMARK 500  8 ASN A 109       54.85   -158.65                                   
REMARK 500  8 THR A 110      100.01    -47.20                                   
REMARK 500  8 SER A 113       98.38    -34.18                                   
REMARK 500  8 HIS A 116       37.96   -145.11                                   
REMARK 500  8 TRP A 121       73.38    -67.42                                   
REMARK 500  8 PHE A 122     -177.25    -50.27                                   
REMARK 500  8 LYS A 126      123.47    -24.44                                   
REMARK 500  8 LYS A 127       60.62    -65.10                                   
REMARK 500  8 ASN A 128      -43.86   -156.61                                   
REMARK 500  8 SER A 130      139.46    169.38                                   
REMARK 500  8 ARG A 136       25.23   -158.34                                   
REMARK 500  8 TYR A 139     -164.83    -54.01                                   
REMARK 500  8 LYS A 142      -14.99    -49.71                                   
REMARK 500  8 VAL A 151       41.26   -176.01                                   
REMARK 500  8 SER A 152       81.64    -61.30                                   
REMARK 500  8 SER A 153       69.69   -119.93                                   
REMARK 500  9 SER A  31      -93.63    -58.27                                   
REMARK 500  9 ASP A  46     -170.74    178.66                                   
REMARK 500  9 SER A  52       69.56    179.96                                   
REMARK 500  9 HIS A  55       96.53   -175.82                                   
REMARK 500  9 GLN A  59      131.04   -178.75                                   
REMARK 500  9 SER A  61       55.01   -145.16                                   
REMARK 500  9 ALA A  62      125.87    -39.22                                   
REMARK 500  9 SER A  64      131.74    160.33                                   
REMARK 500  9 THR A  73      101.44    -34.56                                   
REMARK 500  9 GLU A  74      -58.07    174.22                                   
REMARK 500  9 LEU A  79      157.37    -46.82                                   
REMARK 500  9 GLN A  91       38.98    -88.86                                   
REMARK 500  9 LEU A  98      171.58    -55.89                                   
REMARK 500  9 LEU A 100       97.45    -49.59                                   
REMARK 500  9 ARG A 102     -100.92   -135.73                                   
REMARK 500  9 LEU A 103      122.08    178.53                                   
REMARK 500  9 GLU A 105     -117.04   -121.43                                   
REMARK 500  9 ASN A 106       52.05   -153.43                                   
REMARK 500  9 HIS A 107      -54.53   -170.78                                   
REMARK 500  9 TYR A 108     -158.21    -70.61                                   
REMARK 500  9 ASN A 109       57.46   -164.21                                   
REMARK 500  9 THR A 110      153.02    -39.56                                   
REMARK 500  9 SER A 113      100.80    -40.20                                   
REMARK 500  9 HIS A 116       66.27   -160.30                                   
REMARK 500  9 TRP A 121       77.80    -69.93                                   
REMARK 500  9 LYS A 126      125.48    -24.60                                   
REMARK 500  9 LYS A 127       60.92    -64.76                                   
REMARK 500  9 ASN A 128      -41.92   -155.58                                   
REMARK 500  9 SER A 130      132.00    169.50                                   
REMARK 500  9 ARG A 136       41.01    168.63                                   
REMARK 500  9 TYR A 139       80.59    -59.84                                   
REMARK 500  9 LYS A 142       46.47    -83.77                                   
REMARK 500  9 LEU A 145       92.31    -58.53                                   
REMARK 500  9 VAL A 151       44.62   -160.54                                   
REMARK 500  9 SER A 152      103.37    -39.47                                   
REMARK 500  9 SER A 153       72.29    179.78                                   
REMARK 500 10 LYS A  26      140.72   -179.87                                   
REMARK 500 10 LEU A  27      139.68   -175.23                                   
REMARK 500 10 SER A  31      -97.80    -64.50                                   
REMARK 500 10 LEU A  37      146.81    -33.52                                   
REMARK 500 10 ASP A  46     -171.30    170.08                                   
REMARK 500 10 ARG A  49      -32.04    -39.60                                   
REMARK 500 10 ASP A  50      118.88   -160.11                                   
REMARK 500 10 ARG A  51       93.61    -31.03                                   
REMARK 500 10 GLN A  59      147.78   -170.50                                   
REMARK 500 10 SER A  61       53.86   -143.89                                   
REMARK 500 10 ALA A  62      126.01    -39.84                                   
REMARK 500 10 SER A  64      126.83    159.67                                   
REMARK 500 10 VAL A  65      142.90    -39.63                                   
REMARK 500 10 GLU A  67      106.02   -168.35                                   
REMARK 500 10 THR A  73       98.35    -45.09                                   
REMARK 500 10 GLU A  74      -38.35    159.68                                   
REMARK 500 10 THR A  75     -124.56   -119.28                                   
REMARK 500 10 GLN A  77     -161.88   -101.55                                   
REMARK 500 10 ALA A  80     -175.49   -177.21                                   
REMARK 500 10 LEU A  87      119.35    -38.85                                   
REMARK 500 10 ASN A  94     -152.24   -156.32                                   
REMARK 500 10 GLU A  95       69.58    -66.36                                   
REMARK 500 10 GLU A  96      -43.71   -177.94                                   
REMARK 500 10 LEU A  98      172.37    -59.55                                   
REMARK 500 10 LEU A 100       98.29    -46.31                                   
REMARK 500 10 ARG A 102       78.00    179.74                                   
REMARK 500 10 LEU A 103       95.20    -31.43                                   
REMARK 500 10 GLU A 105     -107.05   -130.11                                   
REMARK 500 10 HIS A 107      -70.73   -178.29                                   
REMARK 500 10 SER A 113       99.20    -34.57                                   
REMARK 500 10 HIS A 116       67.60    179.85                                   
REMARK 500 10 LYS A 126      118.67    -24.47                                   
REMARK 500 10 LYS A 127       61.49    -63.26                                   
REMARK 500 10 ASN A 128      -45.33   -143.10                                   
REMARK 500 10 SER A 130      128.61    168.73                                   
REMARK 500 10 CYS A 131      158.63    -41.52                                   
REMARK 500 10 ARG A 136       39.65    169.65                                   
REMARK 500 10 TYR A 139     -170.07    -52.00                                   
REMARK 500 10 VAL A 151       36.88   -170.62                                   
REMARK 500 10 SER A 152       98.99    -39.65                                   
REMARK 500 10 SER A 153       72.58   -172.02                                   
REMARK 500 11 SER A  31     -161.34    -57.08                                   
REMARK 500 11 ASN A  32      148.13    -36.06                                   
REMARK 500 11 LEU A  37      152.46    -38.74                                   
REMARK 500 11 ASP A  46     -170.43    174.02                                   
REMARK 500 11 ARG A  51       96.60    -33.79                                   
REMARK 500 11 SER A  52       50.16   -143.25                                   
REMARK 500 11 SER A  61       51.81   -145.26                                   
REMARK 500 11 ALA A  62      125.08    -39.26                                   
REMARK 500 11 SER A  64      140.05    157.07                                   
REMARK 500 11 SER A  72       93.16    -62.05                                   
REMARK 500 11 THR A  73       89.08    -52.80                                   
REMARK 500 11 GLU A  74      -60.94    160.62                                   
REMARK 500 11 THR A  75     -135.80    -99.52                                   
REMARK 500 11 LEU A  79      160.06    -42.36                                   
REMARK 500 11 GLU A  95      -39.36    -38.45                                   
REMARK 500 11 ARG A 102      -94.51   -146.60                                   
REMARK 500 11 LEU A 103      117.32    178.38                                   
REMARK 500 11 GLU A 105     -100.49   -130.34                                   
REMARK 500 11 ASN A 106       40.36   -170.23                                   
REMARK 500 11 HIS A 107      -61.48   -166.48                                   
REMARK 500 11 TYR A 108     -164.31    -65.02                                   
REMARK 500 11 ASN A 109       82.09   -158.16                                   
REMARK 500 11 SER A 113       91.81    -49.87                                   
REMARK 500 11 HIS A 116       75.76   -166.25                                   
REMARK 500 11 TRP A 121       92.10    -53.97                                   
REMARK 500 11 PHE A 122     -170.07    -69.63                                   
REMARK 500 11 LYS A 126      125.01    -36.89                                   
REMARK 500 11 LYS A 127       59.84    -66.09                                   
REMARK 500 11 ASN A 128      -43.02   -144.76                                   
REMARK 500 11 SER A 130      140.81   -179.46                                   
REMARK 500 11 ARG A 136       40.29    169.56                                   
REMARK 500 11 TYR A 139     -166.57    -68.99                                   
REMARK 500 11 GLN A 141      -74.91   -111.86                                   
REMARK 500 11 LYS A 142       58.22    169.46                                   
REMARK 500 11 LEU A 145      100.08    -57.69                                   
REMARK 500 11 VAL A 151       58.30   -159.50                                   
REMARK 500 11 SER A 152       80.20    -62.11                                   
REMARK 500 12 SER A  31      -73.19    -68.90                                   
REMARK 500 12 LEU A  37      148.31    -34.24                                   
REMARK 500 12 ASP A  46     -176.98    178.83                                   
REMARK 500 12 SER A  52       68.80   -179.85                                   
REMARK 500 12 HIS A  55       98.79   -173.87                                   
REMARK 500 12 GLN A  59      148.21   -179.59                                   
REMARK 500 12 SER A  61       54.73   -142.83                                   
REMARK 500 12 ALA A  62      131.08    -37.74                                   
REMARK 500 12 SER A  64      120.77    157.62                                   
REMARK 500 12 VAL A  65      150.74    -36.16                                   
REMARK 500 12 GLU A  67      104.07   -175.35                                   
REMARK 500 12 SER A  72       81.72    -65.45                                   
REMARK 500 12 THR A  73       94.95    -35.18                                   
REMARK 500 12 GLU A  74      -85.94    175.74                                   
REMARK 500 12 THR A  75       59.74   -113.76                                   
REMARK 500 12 LEU A  87      135.69    -39.01                                   
REMARK 500 12 GLN A  91       38.71    -88.44                                   
REMARK 500 12 LEU A  98      166.47    -48.13                                   
REMARK 500 12 LEU A 100       99.00    -39.86                                   
REMARK 500 12 ARG A 102       91.22   -179.53                                   
REMARK 500 12 LEU A 103      102.30    -20.21                                   
REMARK 500 12 GLU A 105      -97.17   -130.12                                   
REMARK 500 12 ASN A 106       49.31   -164.94                                   
REMARK 500 12 HIS A 107      -51.29   -176.02                                   
REMARK 500 12 TYR A 108     -160.46    -68.88                                   
REMARK 500 12 ASN A 109       40.26   -167.29                                   
REMARK 500 12 THR A 110      153.27    -42.78                                   
REMARK 500 12 SER A 113      101.00    -30.97                                   
REMARK 500 12 HIS A 116       63.49   -177.05                                   
REMARK 500 12 TRP A 121       77.17    -66.22                                   
REMARK 500 12 LYS A 126      124.29    -22.13                                   
REMARK 500 12 LYS A 127       59.14    -66.12                                   
REMARK 500 12 ASN A 128      -46.60   -151.37                                   
REMARK 500 12 SER A 130      128.54    168.92                                   
REMARK 500 12 CYS A 131     -178.18    -52.42                                   
REMARK 500 12 ARG A 136       39.51    173.12                                   
REMARK 500 12 HIS A 138     -147.76   -140.24                                   
REMARK 500 12 TYR A 139     -160.29    -67.71                                   
REMARK 500 12 LYS A 142      -25.44    -35.36                                   
REMARK 500 12 LEU A 145       78.27    -68.77                                   
REMARK 500 12 PRO A 150     -168.39    -75.03                                   
REMARK 500 12 VAL A 151       39.89   -173.70                                   
REMARK 500 12 SER A 152       82.78    -60.60                                   
REMARK 500 13 SER A  31      -86.00    -59.91                                   
REMARK 500 13 LEU A  37      154.26    -37.37                                   
REMARK 500 13 ASP A  46     -170.33    175.06                                   
REMARK 500 13 ARG A  51      115.25    -31.50                                   
REMARK 500 13 SER A  52       64.65   -172.57                                   
REMARK 500 13 HIS A  55      111.69    174.15                                   
REMARK 500 13 GLN A  59      142.61   -173.95                                   
REMARK 500 13 SER A  61       51.29   -143.36                                   
REMARK 500 13 ALA A  62      124.55    -39.68                                   
REMARK 500 13 SER A  64      175.37    165.60                                   
REMARK 500 13 GLU A  67      107.38   -169.12                                   
REMARK 500 13 SER A  72       79.33    -61.94                                   
REMARK 500 13 THR A  73       92.74    -49.76                                   
REMARK 500 13 GLU A  74      -46.75    164.03                                   
REMARK 500 13 LEU A  79      145.05    -38.73                                   
REMARK 500 13 ASP A  82      166.36    -44.14                                   
REMARK 500 13 LEU A  87      134.35    -39.75                                   
REMARK 500 13 LEU A  98      174.66    -50.47                                   
REMARK 500 13 LEU A 100       98.53    -61.46                                   
REMARK 500 13 ARG A 102      -96.68   -144.53                                   
REMARK 500 13 LEU A 103      117.02    178.90                                   
REMARK 500 13 GLU A 105      -92.25   -130.05                                   
REMARK 500 13 ASN A 106       58.96   -179.12                                   
REMARK 500 13 HIS A 107      -43.33    179.97                                   
REMARK 500 13 TYR A 108     -154.48    -89.24                                   
REMARK 500 13 ASN A 109       66.50   -168.23                                   
REMARK 500 13 THR A 110       99.92    -55.60                                   
REMARK 500 13 ILE A 112      119.99   -163.46                                   
REMARK 500 13 SER A 113      101.60    -35.03                                   
REMARK 500 13 HIS A 116       39.74   -152.48                                   
REMARK 500 13 TRP A 121       78.98    -64.55                                   
REMARK 500 13 PHE A 122     -171.18    -54.21                                   
REMARK 500 13 LYS A 126      116.94    -22.77                                   
REMARK 500 13 LYS A 127       61.98    -62.70                                   
REMARK 500 13 ASN A 128      -43.81   -141.12                                   
REMARK 500 13 SER A 130      114.91    169.68                                   
REMARK 500 13 CYS A 131      156.75    -41.70                                   
REMARK 500 13 ARG A 136       37.27    176.94                                   
REMARK 500 13 TYR A 139     -164.83    -54.80                                   
REMARK 500 13 LEU A 145       90.70    -65.11                                   
REMARK 500 13 PRO A 150     -168.90    -75.03                                   
REMARK 500 13 VAL A 151       41.24   -178.64                                   
REMARK 500 13 SER A 152      108.79    -46.42                                   
REMARK 500 14 LYS A  26      146.71   -176.77                                   
REMARK 500 14 SER A  31     -117.64    -71.23                                   
REMARK 500 14 LEU A  37      141.00    -29.90                                   
REMARK 500 14 ASP A  46     -171.36    174.29                                   
REMARK 500 14 ARG A  51      122.25    -35.98                                   
REMARK 500 14 SER A  52       70.24    179.65                                   
REMARK 500 14 HIS A  55      105.84   -172.99                                   
REMARK 500 14 SER A  61       50.20   -143.02                                   
REMARK 500 14 SER A  64      135.33    158.90                                   
REMARK 500 14 SER A  72       84.75    -57.23                                   
REMARK 500 14 GLU A  74      -38.30    164.44                                   
REMARK 500 14 ASN A  94     -150.38   -157.26                                   
REMARK 500 14 GLU A  95       69.01    -66.11                                   
REMARK 500 14 GLU A  96      -54.60   -178.27                                   
REMARK 500 14 LEU A  98     -179.21    -54.98                                   
REMARK 500 14 ARG A 102       79.49   -173.05                                   
REMARK 500 14 LEU A 103       96.50    -28.57                                   
REMARK 500 14 GLU A 105     -105.04   -130.23                                   
REMARK 500 14 ASN A 106       36.68   -143.32                                   
REMARK 500 14 HIS A 107      -66.33   -176.09                                   
REMARK 500 14 ASN A 109       78.30   -109.00                                   
REMARK 500 14 THR A 110       93.68    -68.42                                   
REMARK 500 14 SER A 113      100.44    -35.89                                   
REMARK 500 14 HIS A 116       70.07   -175.02                                   
REMARK 500 14 TRP A 121       80.82    -63.40                                   
REMARK 500 14 LYS A 126      115.35    -22.29                                   
REMARK 500 14 LYS A 127       61.37    -62.46                                   
REMARK 500 14 ASN A 128      -42.37   -135.24                                   
REMARK 500 14 SER A 130      135.30    169.63                                   
REMARK 500 14 CYS A 131      171.43    -47.52                                   
REMARK 500 14 ARG A 136       38.27    175.68                                   
REMARK 500 14 THR A 137       93.71   -162.14                                   
REMARK 500 14 TYR A 139     -156.51    -56.77                                   
REMARK 500 14 VAL A 151       46.86   -174.48                                   
REMARK 500 14 SER A 152       84.50    -59.00                                   
REMARK 500 14 SER A 153       74.03   -112.51                                   
REMARK 500 15 SER A  31      -83.51    -66.72                                   
REMARK 500 15 LEU A  37      152.97    -36.82                                   
REMARK 500 15 ASP A  46     -170.49    174.27                                   
REMARK 500 15 ARG A  51       92.87    -25.67                                   
REMARK 500 15 SER A  61       49.45   -147.01                                   
REMARK 500 15 ALA A  62      124.65    -38.86                                   
REMARK 500 15 SER A  64      173.28    177.55                                   
REMARK 500 15 GLU A  67      118.91   -166.94                                   
REMARK 500 15 SER A  72       95.56    -54.11                                   
REMARK 500 15 THR A  73       93.14    -54.52                                   
REMARK 500 15 GLU A  74      -58.30    173.82                                   
REMARK 500 15 THR A  75     -120.05    -80.27                                   
REMARK 500 15 ASP A  82      168.91    -46.02                                   
REMARK 500 15 LEU A  87      134.58    -39.38                                   
REMARK 500 15 ASN A  94     -158.48   -149.88                                   
REMARK 500 15 GLU A  95       68.65    -66.57                                   
REMARK 500 15 GLU A  96      -59.21   -178.19                                   
REMARK 500 15 LEU A  98      173.35    -55.21                                   
REMARK 500 15 LEU A 100       98.60    -56.71                                   
REMARK 500 15 ARG A 102       93.63    179.58                                   
REMARK 500 15 LEU A 103       83.92    -58.61                                   
REMARK 500 15 GLU A 105     -102.70   -129.80                                   
REMARK 500 15 ASN A 106       36.48   -141.70                                   
REMARK 500 15 HIS A 107      -59.38   -176.28                                   
REMARK 500 15 THR A 110       99.15    -51.24                                   
REMARK 500 15 TYR A 111     -167.93    -79.55                                   
REMARK 500 15 ILE A 112      119.37   -169.52                                   
REMARK 500 15 SER A 113      100.69    -33.91                                   
REMARK 500 15 HIS A 116       39.84   -143.10                                   
REMARK 500 15 TRP A 121       95.33    -56.47                                   
REMARK 500 15 LYS A 126      119.41    -24.58                                   
REMARK 500 15 LYS A 127       60.63    -64.33                                   
REMARK 500 15 ASN A 128      -44.44   -140.65                                   
REMARK 500 15 SER A 130      123.51    169.08                                   
REMARK 500 15 CYS A 131      156.94    -41.37                                   
REMARK 500 15 ARG A 136       39.24    170.99                                   
REMARK 500 15 TYR A 139     -166.56    -52.85                                   
REMARK 500 15 VAL A 151       36.93   -171.59                                   
REMARK 500 15 SER A 152       97.99    -39.50                                   
REMARK 500 15 SER A 153       71.96   -172.82                                   
REMARK 500 16 LEU A  27      113.63   -174.73                                   
REMARK 500 16 SER A  31      -87.87    -60.72                                   
REMARK 500 16 LEU A  37      159.06    -39.71                                   
REMARK 500 16 ASP A  46     -168.57    176.84                                   
REMARK 500 16 ARG A  51      121.50    -29.82                                   
REMARK 500 16 SER A  52       69.46    179.81                                   
REMARK 500 16 HIS A  55      108.61   -177.80                                   
REMARK 500 16 SER A  64      137.45    157.21                                   
REMARK 500 16 SER A  72      100.20    -50.07                                   
REMARK 500 16 THR A  73       77.91    -55.75                                   
REMARK 500 16 GLU A  74      -73.28    173.21                                   
REMARK 500 16 THR A  75     -132.94    -89.84                                   
REMARK 500 16 LEU A  79      150.57    -42.81                                   
REMARK 500 16 ALA A  80     -178.05   -171.66                                   
REMARK 500 16 LEU A  87      138.27    -38.95                                   
REMARK 500 16 GLN A  91       31.46    -90.35                                   
REMARK 500 16 GLU A  96      -74.16    -57.95                                   
REMARK 500 16 LEU A  98      167.62    -48.90                                   
REMARK 500 16 LEU A 100      101.29    -52.48                                   
REMARK 500 16 ARG A 102       94.31   -179.69                                   
REMARK 500 16 LEU A 103       87.15    -55.84                                   
REMARK 500 16 GLU A 105     -121.49    -99.52                                   
REMARK 500 16 HIS A 107      -61.12   -179.99                                   
REMARK 500 16 TYR A 108      153.17    -43.05                                   
REMARK 500 16 THR A 110       97.21    -54.56                                   
REMARK 500 16 SER A 113       96.02    -42.03                                   
REMARK 500 16 HIS A 116       61.14    179.95                                   
REMARK 500 16 LYS A 126      131.49    -36.84                                   
REMARK 500 16 LYS A 127       58.59    -69.34                                   
REMARK 500 16 ASN A 128      -45.55   -143.28                                   
REMARK 500 16 SER A 130      120.75    169.98                                   
REMARK 500 16 CYS A 131      156.47    -49.47                                   
REMARK 500 16 ARG A 136       39.27    169.50                                   
REMARK 500 16 TYR A 139     -171.31    -54.77                                   
REMARK 500 16 GLN A 141      -78.87   -135.50                                   
REMARK 500 16 LYS A 142       44.13    170.86                                   
REMARK 500 16 LEU A 145      100.73    -54.24                                   
REMARK 500 16 VAL A 151       57.76   -167.52                                   
REMARK 500 16 SER A 152       83.39    -60.16                                   
REMARK 500 17 SER A  31      -91.84    -57.85                                   
REMARK 500 17 ASP A  46     -171.23    173.07                                   
REMARK 500 17 ARG A  51       91.49    -49.11                                   
REMARK 500 17 GLN A  59      132.49   -173.13                                   
REMARK 500 17 SER A  61       53.19   -146.62                                   
REMARK 500 17 SER A  64      123.85    160.79                                   
REMARK 500 17 VAL A  65      148.02    -37.31                                   
REMARK 500 17 GLU A  67      106.09   -172.73                                   
REMARK 500 17 SER A  72       71.57    -67.46                                   
REMARK 500 17 THR A  73       89.45    -53.10                                   
REMARK 500 17 GLU A  74      -44.30    171.41                                   
REMARK 500 17 THR A  75     -102.02   -103.01                                   
REMARK 500 17 GLN A  77     -168.95   -125.63                                   
REMARK 500 17 MET A  81       88.42   -153.81                                   
REMARK 500 17 ASP A  82      175.89    -48.88                                   
REMARK 500 17 LEU A  87      114.63    -39.55                                   
REMARK 500 17 GLN A  91       38.27    -89.32                                   
REMARK 500 17 GLU A  96      -73.55    -56.26                                   
REMARK 500 17 LEU A  98      172.15    -51.28                                   
REMARK 500 17 LEU A 100       97.03    -39.64                                   
REMARK 500 17 ARG A 102       76.89    178.55                                   
REMARK 500 17 LEU A 103       98.19    -35.12                                   
REMARK 500 17 GLU A 105     -100.69   -115.12                                   
REMARK 500 17 ASN A 106       50.63   -146.42                                   
REMARK 500 17 HIS A 107      -52.91    179.97                                   
REMARK 500 17 ASN A 109       50.60   -102.36                                   
REMARK 500 17 THR A 110       97.88    -47.35                                   
REMARK 500 17 SER A 113       95.40    -39.74                                   
REMARK 500 17 HIS A 116       65.39   -163.93                                   
REMARK 500 17 LYS A 126      122.49    -24.75                                   
REMARK 500 17 LYS A 127       60.79    -65.03                                   
REMARK 500 17 ASN A 128      -41.86   -160.68                                   
REMARK 500 17 SER A 130      158.48    169.80                                   
REMARK 500 17 ARG A 133       58.12   -165.63                                   
REMARK 500 17 TYR A 139     -167.90    -53.13                                   
REMARK 500 17 VAL A 151       36.64   -163.81                                   
REMARK 500 17 SER A 152       99.15    -41.99                                   
REMARK 500 17 SER A 153       73.02   -171.16                                   
REMARK 500 18 LYS A  26      145.66   -176.98                                   
REMARK 500 18 SER A  31     -142.21    -68.22                                   
REMARK 500 18 ASN A  32      145.82    -36.99                                   
REMARK 500 18 HIS A  35     -159.39   -101.09                                   
REMARK 500 18 LEU A  37      163.79    -41.55                                   
REMARK 500 18 ASP A  46     -173.78    177.97                                   
REMARK 500 18 ARG A  51      116.38    -25.96                                   
REMARK 500 18 SER A  52       69.97    179.56                                   
REMARK 500 18 HIS A  55      102.65   -166.55                                   
REMARK 500 18 SER A  61       53.53   -147.06                                   
REMARK 500 18 SER A  64      130.51    158.57                                   
REMARK 500 18 GLU A  67      106.05   -164.56                                   
REMARK 500 18 SER A  72       79.01    -66.61                                   
REMARK 500 18 THR A  73       90.32    -51.22                                   
REMARK 500 18 GLU A  74      -40.22   -170.72                                   
REMARK 500 18 THR A  75       58.24   -157.79                                   
REMARK 500 18 LEU A  79      157.47    -46.63                                   
REMARK 500 18 ALA A  80     -169.76   -170.76                                   
REMARK 500 18 MET A  81       88.27   -155.74                                   
REMARK 500 18 ASP A  82      165.53    -46.57                                   
REMARK 500 18 LEU A  87      120.91    -39.79                                   
REMARK 500 18 GLN A  91       38.86    -89.03                                   
REMARK 500 18 ASN A  94     -154.64   -157.68                                   
REMARK 500 18 GLU A  95       59.94    -69.38                                   
REMARK 500 18 GLU A  96      -47.97   -167.14                                   
REMARK 500 18 LEU A 100       99.63    -62.56                                   
REMARK 500 18 ARG A 102       82.12   -155.04                                   
REMARK 500 18 LEU A 103       99.68    -29.93                                   
REMARK 500 18 GLU A 105     -106.54   -110.96                                   
REMARK 500 18 ASN A 106       39.75   -147.83                                   
REMARK 500 18 HIS A 107      -76.96   -165.09                                   
REMARK 500 18 TYR A 108      171.59    -45.34                                   
REMARK 500 18 THR A 110      109.47    -48.27                                   
REMARK 500 18 SER A 113       98.01    -32.46                                   
REMARK 500 18 HIS A 116       69.87   -177.16                                   
REMARK 500 18 TRP A 121       83.82    -60.62                                   
REMARK 500 18 PHE A 122     -172.45    -60.05                                   
REMARK 500 18 LYS A 126      118.51    -24.39                                   
REMARK 500 18 LYS A 127       60.98    -62.43                                   
REMARK 500 18 ASN A 128      -45.66   -142.66                                   
REMARK 500 18 SER A 130      150.77    168.59                                   
REMARK 500 18 ARG A 136       23.32   -155.27                                   
REMARK 500 18 TYR A 139     -156.46    -56.52                                   
REMARK 500 18 LYS A 142      -24.91    -39.04                                   
REMARK 500 18 VAL A 151       54.98   -171.76                                   
REMARK 500 18 SER A 152       89.98    -53.63                                   
REMARK 500 19 LYS A  26      138.67    167.63                                   
REMARK 500 19 LEU A  27      115.82   -167.71                                   
REMARK 500 19 LEU A  28     -173.83    -67.48                                   
REMARK 500 19 TYR A  29      152.68    179.39                                   
REMARK 500 19 SER A  31     -106.20    -71.87                                   
REMARK 500 19 ASN A  32       95.29    -38.76                                   
REMARK 500 19 LEU A  37      149.22    -34.95                                   
REMARK 500 19 ASP A  46     -163.32   -177.96                                   
REMARK 500 19 ARG A  51      111.34    -24.28                                   
REMARK 500 19 SER A  52       60.44   -161.88                                   
REMARK 500 19 GLN A  59      117.73   -167.03                                   
REMARK 500 19 SER A  61       47.34   -144.89                                   
REMARK 500 19 ALA A  62      124.03    -38.20                                   
REMARK 500 19 SER A  64     -163.29    178.39                                   
REMARK 500 19 GLU A  67      127.55   -178.27                                   
REMARK 500 19 THR A  73       84.73    -64.10                                   
REMARK 500 19 GLU A  74      -44.43    179.32                                   
REMARK 500 19 LEU A  87      132.47    -38.64                                   
REMARK 500 19 LEU A 100      105.02    -42.97                                   
REMARK 500 19 ARG A 102      -90.90   -139.21                                   
REMARK 500 19 LEU A 103      119.85    178.41                                   
REMARK 500 19 GLU A 105      -98.72   -130.37                                   
REMARK 500 19 ASN A 106       36.12   -161.94                                   
REMARK 500 19 HIS A 107      -69.00   -165.16                                   
REMARK 500 19 TYR A 108     -175.02    -51.35                                   
REMARK 500 19 ASN A 109       76.66   -151.36                                   
REMARK 500 19 THR A 110       98.40    -68.06                                   
REMARK 500 19 SER A 113      109.56    -34.79                                   
REMARK 500 19 HIS A 116       69.35   -179.96                                   
REMARK 500 19 LYS A 126      116.87    -24.51                                   
REMARK 500 19 LYS A 127       60.05    -63.56                                   
REMARK 500 19 ASN A 128      -43.84   -140.77                                   
REMARK 500 19 SER A 130      144.78    168.48                                   
REMARK 500 19 ARG A 133      170.47    -59.73                                   
REMARK 500 19 ARG A 136       28.42   -164.93                                   
REMARK 500 19 TYR A 139     -164.59    -54.36                                   
REMARK 500 19 VAL A 151       44.35   -177.47                                   
REMARK 500 19 SER A 152      104.84    -42.25                                   
REMARK 500 19 SER A 153       71.20   -173.19                                   
REMARK 500 20 LYS A  26      146.33   -170.25                                   
REMARK 500 20 SER A  31      -87.90    -46.15                                   
REMARK 500 20 LEU A  37      164.55    -46.63                                   
REMARK 500 20 ASP A  46     -169.38    176.41                                   
REMARK 500 20 ARG A  51      123.63    -36.47                                   
REMARK 500 20 SER A  52       68.80   -179.67                                   
REMARK 500 20 HIS A  55      104.90   -171.03                                   
REMARK 500 20 GLN A  57      153.11    -45.16                                   
REMARK 500 20 GLN A  59      132.67   -178.46                                   
REMARK 500 20 SER A  61       56.77   -145.12                                   
REMARK 500 20 SER A  64      142.66    158.65                                   
REMARK 500 20 GLU A  67      103.91   -164.13                                   
REMARK 500 20 SER A  72       74.75    -64.36                                   
REMARK 500 20 THR A  73       94.15    -45.80                                   
REMARK 500 20 GLU A  74      -36.15    166.88                                   
REMARK 500 20 THR A  75     -102.95    -97.56                                   
REMARK 500 20 LEU A  79      161.57    -45.65                                   
REMARK 500 20 LEU A  87      123.31    -39.15                                   
REMARK 500 20 ASN A  94     -152.31   -157.19                                   
REMARK 500 20 GLU A  95       68.56    -66.75                                   
REMARK 500 20 GLU A  96      -43.66    179.95                                   
REMARK 500 20 ARG A 102       81.98    179.35                                   
REMARK 500 20 LEU A 103       94.30    -29.56                                   
REMARK 500 20 GLU A 105     -105.43   -110.35                                   
REMARK 500 20 ASN A 106       43.26   -150.35                                   
REMARK 500 20 HIS A 107      -58.31   -177.16                                   
REMARK 500 20 ASN A 109       65.81   -117.86                                   
REMARK 500 20 THR A 110       96.48    -53.78                                   
REMARK 500 20 SER A 113       88.09    -55.35                                   
REMARK 500 20 HIS A 116       72.32    179.97                                   
REMARK 500 20 TRP A 121       90.07    -55.60                                   
REMARK 500 20 LYS A 126      131.37    -35.60                                   
REMARK 500 20 LYS A 127       58.19    -68.05                                   
REMARK 500 20 ASN A 128      -45.25   -150.80                                   
REMARK 500 20 SER A 130      140.88    169.90                                   
REMARK 500 20 PRO A 135       49.13    -75.06                                   
REMARK 500 20 ARG A 136       38.42    169.39                                   
REMARK 500 20 TYR A 139     -177.78    -68.68                                   
REMARK 500 20 GLN A 141      -77.73   -123.41                                   
REMARK 500 20 LYS A 142       39.71    173.84                                   
REMARK 500 20 LEU A 145       92.59    -50.63                                   
REMARK 500 20 VAL A 151       49.96   -164.06                                   
REMARK 500 20 SER A 153       75.77   -113.24                                   
REMARK 500 21 LYS A  26      128.78    178.09                                   
REMARK 500 21 SER A  31      -91.68    -30.04                                   
REMARK 500 21 ASN A  32     -175.15    -52.50                                   
REMARK 500 21 LEU A  37      148.22    -34.60                                   
REMARK 500 21 ASP A  46     -171.52    173.61                                   
REMARK 500 21 ARG A  49      -34.38    -38.60                                   
REMARK 500 21 ARG A  51      120.57    -36.38                                   
REMARK 500 21 SER A  52       68.41   -179.16                                   
REMARK 500 21 HIS A  55      106.27   -173.99                                   
REMARK 500 21 GLN A  59      127.73   -174.14                                   
REMARK 500 21 SER A  61       51.61   -144.44                                   
REMARK 500 21 ALA A  62      125.95    -39.01                                   
REMARK 500 21 SER A  64      127.13    157.63                                   
REMARK 500 21 VAL A  65      144.89    -38.89                                   
REMARK 500 21 GLU A  67      105.19   -170.59                                   
REMARK 500 21 SER A  72       78.58    -63.01                                   
REMARK 500 21 GLU A  74      -42.53    165.58                                   
REMARK 500 21 THR A  75       50.99   -152.87                                   
REMARK 500 21 LEU A  87      124.79    -39.83                                   
REMARK 500 21 GLU A  95      -33.40    -36.51                                   
REMARK 500 21 LEU A  98      172.70    -52.27                                   
REMARK 500 21 LEU A 100      103.44    -49.52                                   
REMARK 500 21 ARG A 102       67.57   -162.13                                   
REMARK 500 21 LEU A 103       95.02    -21.01                                   
REMARK 500 21 GLU A 105     -102.57   -113.11                                   
REMARK 500 21 ASN A 106       40.25   -143.78                                   
REMARK 500 21 HIS A 107      -47.02    179.85                                   
REMARK 500 21 ASN A 109       49.65    -89.91                                   
REMARK 500 21 THR A 110       99.89    -40.67                                   
REMARK 500 21 SER A 113      100.60    -36.19                                   
REMARK 500 21 HIS A 116       70.92   -179.92                                   
REMARK 500 21 TRP A 121      109.38    -51.15                                   
REMARK 500 21 LYS A 126      112.74    -23.01                                   
REMARK 500 21 LYS A 127       62.06    -60.91                                   
REMARK 500 21 ASN A 128      -41.51   -137.02                                   
REMARK 500 21 SER A 130      131.45    169.52                                   
REMARK 500 21 CYS A 131      172.87    -48.11                                   
REMARK 500 21 ARG A 136       37.94    177.28                                   
REMARK 500 21 TYR A 139     -159.55    -54.97                                   
REMARK 500 21 LYS A 142      -28.17    -33.74                                   
REMARK 500 21 PRO A 150     -169.37    -75.06                                   
REMARK 500 21 VAL A 151       28.56   -161.35                                   
REMARK 500 21 SER A 152      102.03    -41.65                                   
REMARK 500 22 LYS A  26      145.05   -177.29                                   
REMARK 500 22 SER A  31     -163.36    -55.39                                   
REMARK 500 22 ASN A  32      146.75    -35.50                                   
REMARK 500 22 LEU A  37      132.05    -39.00                                   
REMARK 500 22 ASP A  46     -173.08    175.86                                   
REMARK 500 22 ARG A  49      -36.25    -37.52                                   
REMARK 500 22 ARG A  51      114.75    -36.80                                   
REMARK 500 22 SER A  52       65.63   -172.52                                   
REMARK 500 22 HIS A  55      110.10    175.03                                   
REMARK 500 22 GLN A  59      136.54   -178.52                                   
REMARK 500 22 SER A  61       53.55   -145.44                                   
REMARK 500 22 ALA A  62      126.41    -39.35                                   
REMARK 500 22 SER A  64      172.79    172.66                                   
REMARK 500 22 GLU A  67      109.18   -163.59                                   
REMARK 500 22 SER A  72       83.26    -57.83                                   
REMARK 500 22 THR A  73       82.49    -59.32                                   
REMARK 500 22 GLU A  74      -53.05   -164.08                                   
REMARK 500 22 LEU A  87      129.18    -39.48                                   
REMARK 500 22 ASN A  94     -156.70   -130.53                                   
REMARK 500 22 LEU A  98      167.19    -44.90                                   
REMARK 500 22 LEU A 100       99.95    -58.38                                   
REMARK 500 22 ARG A 102       82.61    177.07                                   
REMARK 500 22 LEU A 103       97.01    -27.99                                   
REMARK 500 22 GLU A 105     -107.13   -124.46                                   
REMARK 500 22 ASN A 106       37.51   -152.29                                   
REMARK 500 22 HIS A 107      -71.94   -169.44                                   
REMARK 500 22 TYR A 108     -178.67    -49.24                                   
REMARK 500 22 THR A 110       96.03    -68.86                                   
REMARK 500 22 SER A 113      102.97    -35.86                                   
REMARK 500 22 HIS A 116       73.74   -172.91                                   
REMARK 500 22 TRP A 121       89.19    -59.35                                   
REMARK 500 22 PHE A 122     -173.24    -66.89                                   
REMARK 500 22 LYS A 126      128.29    -37.37                                   
REMARK 500 22 LYS A 127       58.94    -66.88                                   
REMARK 500 22 ASN A 128      -43.71   -132.29                                   
REMARK 500 22 SER A 130      134.61    169.72                                   
REMARK 500 22 CYS A 131      172.25    -47.78                                   
REMARK 500 22 ARG A 136       33.08   -175.88                                   
REMARK 500 22 TYR A 139     -175.10    -65.23                                   
REMARK 500 22 GLN A 141      -76.07   -134.05                                   
REMARK 500 22 LYS A 142       52.02    169.59                                   
REMARK 500 22 LEU A 145       99.05    -55.77                                   
REMARK 500 22 VAL A 151       62.55   -173.97                                   
REMARK 500 22 SER A 152       80.37    -62.18                                   
REMARK 500 23 LEU A  27      146.09   -176.17                                   
REMARK 500 23 SER A  31      -70.78    -37.86                                   
REMARK 500 23 LEU A  37      132.03    -37.77                                   
REMARK 500 23 ASP A  46     -171.17    171.94                                   
REMARK 500 23 SER A  52       68.06   -178.02                                   
REMARK 500 23 HIS A  55      108.86   -179.49                                   
REMARK 500 23 SER A  61       52.61   -149.96                                   
REMARK 500 23 SER A  64      151.74    161.78                                   
REMARK 500 23 THR A  73       95.42    -29.14                                   
REMARK 500 23 GLU A  74      -70.21    176.18                                   
REMARK 500 23 LEU A  87      126.86    -38.18                                   
REMARK 500 23 GLN A  91       41.50    -88.00                                   
REMARK 500 23 ASN A  94     -152.99   -160.46                                   
REMARK 500 23 GLU A  95       72.11    -65.58                                   
REMARK 500 23 GLU A  96      -58.33    179.88                                   
REMARK 500 23 LEU A  98      170.10    -45.83                                   
REMARK 500 23 LEU A 100      100.09    -48.20                                   
REMARK 500 23 ARG A 102      -93.60   -151.70                                   
REMARK 500 23 LEU A 103      119.01   -176.45                                   
REMARK 500 23 GLU A 105     -114.46   -130.17                                   
REMARK 500 23 HIS A 107      -66.96   -170.12                                   
REMARK 500 23 TYR A 108      159.08    -38.82                                   
REMARK 500 23 THR A 110       99.48    -60.27                                   
REMARK 500 23 SER A 113       93.16    -48.36                                   
REMARK 500 23 HIS A 116       71.11   -168.02                                   
REMARK 500 23 TRP A 121       86.71    -64.44                                   
REMARK 500 23 LYS A 126      131.27    -33.81                                   
REMARK 500 23 LYS A 127       59.34    -68.08                                   
REMARK 500 23 ASN A 128      -44.13   -154.85                                   
REMARK 500 23 SER A 130      151.07    170.53                                   
REMARK 500 23 PRO A 135       49.01    -75.03                                   
REMARK 500 23 ARG A 136       39.54    168.99                                   
REMARK 500 23 TYR A 139     -178.25    -66.26                                   
REMARK 500 23 GLN A 141      -82.22   -124.44                                   
REMARK 500 23 LYS A 142       41.29    174.83                                   
REMARK 500 23 LEU A 145      103.68    -51.90                                   
REMARK 500 23 VAL A 151       54.02   -173.54                                   
REMARK 500 23 SER A 152       80.81    -61.69                                   
REMARK 500 24 SER A  31      -71.42    -35.14                                   
REMARK 500 24 LEU A  37      147.62    -33.72                                   
REMARK 500 24 ASP A  46     -171.29    171.43                                   
REMARK 500 24 ARG A  51      103.94    -50.80                                   
REMARK 500 24 SER A  52       56.89   -155.21                                   
REMARK 500 24 ASP A  53     -168.53   -129.08                                   
REMARK 500 24 SER A  61       56.30   -145.97                                   
REMARK 500 24 ALA A  62      127.91    -39.77                                   
REMARK 500 24 SER A  64      137.25    159.13                                   
REMARK 500 24 GLU A  67      104.54   -163.50                                   
REMARK 500 24 SER A  72       71.15    -68.17                                   
REMARK 500 24 THR A  73       89.81    -50.99                                   
REMARK 500 24 GLU A  74      -25.75    159.45                                   
REMARK 500 24 ASP A  82      170.06    -54.78                                   
REMARK 500 24 ASN A  94     -149.72   -158.27                                   
REMARK 500 24 GLU A  95       68.86    -65.93                                   
REMARK 500 24 GLU A  96      -48.63    179.86                                   
REMARK 500 24 LEU A  98      173.21    -47.63                                   
REMARK 500 24 LEU A 100       95.88    -55.38                                   
REMARK 500 24 ARG A 102      -89.15   -153.80                                   
REMARK 500 24 LEU A 103      125.83    179.24                                   
REMARK 500 24 GLU A 105      -97.83   -130.11                                   
REMARK 500 24 ASN A 106       52.92   -166.99                                   
REMARK 500 24 HIS A 107      -62.24   -179.95                                   
REMARK 500 24 TYR A 108     -172.96    -60.77                                   
REMARK 500 24 ASN A 109       84.33   -153.59                                   
REMARK 500 24 SER A 113       98.48    -33.01                                   
REMARK 500 24 HIS A 116       31.43   -148.29                                   
REMARK 500 24 TRP A 121       81.19    -64.16                                   
REMARK 500 24 PHE A 122     -175.51    -58.37                                   
REMARK 500 24 LYS A 126      130.70    -35.05                                   
REMARK 500 24 LYS A 127       59.36    -69.00                                   
REMARK 500 24 ASN A 128      -43.81   -156.55                                   
REMARK 500 24 SER A 130      144.40    174.71                                   
REMARK 500 24 CYS A 131      178.51    -56.60                                   
REMARK 500 24 LYS A 132     -155.38    -85.06                                   
REMARK 500 24 ARG A 136       40.53    169.33                                   
REMARK 500 24 TYR A 139     -167.17    -54.93                                   
REMARK 500 24 GLN A 141     -101.40   -143.74                                   
REMARK 500 24 LYS A 142       23.69   -165.06                                   
REMARK 500 24 LEU A 145       82.36    -58.11                                   
REMARK 500 24 VAL A 151       38.29   -163.79                                   
REMARK 500 24 SER A 152       97.41    -37.78                                   
REMARK 500 25 SER A  31      -73.99    -65.88                                   
REMARK 500 25 LEU A  37      142.65    -34.89                                   
REMARK 500 25 ASP A  46     -171.40    172.27                                   
REMARK 500 25 SER A  52       69.11    179.98                                   
REMARK 500 25 HIS A  55      103.43   -169.42                                   
REMARK 500 25 GLN A  59      134.37   -177.27                                   
REMARK 500 25 SER A  61       51.54   -144.39                                   
REMARK 500 25 SER A  64      132.45    159.35                                   
REMARK 500 25 SER A  72       86.56    -55.91                                   
REMARK 500 25 THR A  73       83.63    -56.20                                   
REMARK 500 25 GLU A  74      -48.19    159.84                                   
REMARK 500 25 GLN A  77     -164.96   -102.00                                   
REMARK 500 25 ASP A  82      169.40    -49.32                                   
REMARK 500 25 LEU A  87      122.06    -39.87                                   
REMARK 500 25 GLN A  91       39.38    -88.21                                   
REMARK 500 25 GLU A  95      -34.61    -38.68                                   
REMARK 500 25 LEU A 100      101.70    -43.13                                   
REMARK 500 25 ARG A 102      -94.65   -142.12                                   
REMARK 500 25 LEU A 103      121.91    178.76                                   
REMARK 500 25 GLU A 105     -103.71   -129.96                                   
REMARK 500 25 ASN A 106       42.47   -161.78                                   
REMARK 500 25 HIS A 107      -51.29   -162.94                                   
REMARK 500 25 ASN A 109       65.80   -152.14                                   
REMARK 500 25 SER A 113      102.65    -37.60                                   
REMARK 500 25 HIS A 116       64.73   -155.59                                   
REMARK 500 25 PHE A 122     -175.57    -54.52                                   
REMARK 500 25 LYS A 126      123.58    -30.79                                   
REMARK 500 25 LYS A 127       58.40    -67.10                                   
REMARK 500 25 ASN A 128      -43.65   -141.41                                   
REMARK 500 25 SER A 130      132.42    169.89                                   
REMARK 500 25 ARG A 136       26.61   -160.07                                   
REMARK 500 25 TYR A 139     -160.78    -55.80                                   
REMARK 500 25 LYS A 142      -14.04    -49.13                                   
REMARK 500 25 LEU A 145       85.47    -68.77                                   
REMARK 500 25 VAL A 151       47.51   -172.20                                   
REMARK 500 25 SER A 152       96.01    -43.25                                   
REMARK 500 26 LEU A  27      126.85   -174.04                                   
REMARK 500 26 SER A  31      -95.46    -71.32                                   
REMARK 500 26 HIS A  35     -157.26   -106.55                                   
REMARK 500 26 LEU A  37      153.71    -35.77                                   
REMARK 500 26 ASP A  46     -172.10    175.73                                   
REMARK 500 26 SER A  52       70.46    179.45                                   
REMARK 500 26 HIS A  55      106.09   -173.45                                   
REMARK 500 26 SER A  61       52.99   -145.74                                   
REMARK 500 26 SER A  64      130.03    159.00                                   
REMARK 500 26 VAL A  65      142.94    -39.12                                   
REMARK 500 26 GLU A  67      103.95   -165.23                                   
REMARK 500 26 THR A  73       98.63    -38.53                                   
REMARK 500 26 GLU A  74      -51.86    175.54                                   
REMARK 500 26 LEU A  87      134.28    -38.62                                   
REMARK 500 26 GLU A  95      -31.27    -37.77                                   
REMARK 500 26 LEU A  98      174.16    -59.95                                   
REMARK 500 26 LEU A 100      101.36    -57.19                                   
REMARK 500 26 ARG A 102       86.28    179.73                                   
REMARK 500 26 LEU A 103       94.40    -35.76                                   
REMARK 500 26 GLU A 105     -104.74   -126.56                                   
REMARK 500 26 HIS A 107      -66.97   -165.81                                   
REMARK 500 26 SER A 113      106.00    -38.34                                   
REMARK 500 26 HIS A 116       63.95    179.87                                   
REMARK 500 26 TRP A 121      108.22    -59.23                                   
REMARK 500 26 LYS A 126      117.52    -23.76                                   
REMARK 500 26 LYS A 127       60.44    -63.62                                   
REMARK 500 26 ASN A 128      -44.66   -140.13                                   
REMARK 500 26 SER A 130      125.17    168.54                                   
REMARK 500 26 CYS A 131      162.73    -45.04                                   
REMARK 500 26 ARG A 136       33.38   -174.35                                   
REMARK 500 26 TYR A 139     -165.88    -53.96                                   
REMARK 500 26 VAL A 151       51.10   -171.91                                   
REMARK 500 26 SER A 152       85.83    -58.18                                   
REMARK 500 26 SER A 153       81.87   -150.80                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NTS A 178                 
DBREF  1RML A    0   154  UNP    P05230   FGF1_HUMAN       1    155             
SEQRES   1 A  155  MET ALA GLU GLY GLU ILE THR THR PHE THR ALA LEU THR          
SEQRES   2 A  155  GLU LYS PHE ASN LEU PRO PRO GLY ASN TYR LYS LYS PRO          
SEQRES   3 A  155  LYS LEU LEU TYR CYS SER ASN GLY GLY HIS PHE LEU ARG          
SEQRES   4 A  155  ILE LEU PRO ASP GLY THR VAL ASP GLY THR ARG ASP ARG          
SEQRES   5 A  155  SER ASP GLN HIS ILE GLN LEU GLN LEU SER ALA GLU SER          
SEQRES   6 A  155  VAL GLY GLU VAL TYR ILE LYS SER THR GLU THR GLY GLN          
SEQRES   7 A  155  TYR LEU ALA MET ASP THR ASP GLY LEU LEU TYR GLY SER          
SEQRES   8 A  155  GLN THR PRO ASN GLU GLU CYS LEU PHE LEU GLU ARG LEU          
SEQRES   9 A  155  GLU GLU ASN HIS TYR ASN THR TYR ILE SER LYS LYS HIS          
SEQRES  10 A  155  ALA GLU LYS ASN TRP PHE VAL GLY LEU LYS LYS ASN GLY          
SEQRES  11 A  155  SER CYS LYS ARG GLY PRO ARG THR HIS TYR GLY GLN LYS          
SEQRES  12 A  155  ALA ILE LEU PHE LEU PRO LEU PRO VAL SER SER ASP              
HET    NTS  A 178      27                                                       
HETNAM     NTS NAPHTHALENE TRISULFONATE                                         
FORMUL   2  NTS    C10 H5 O9 S3 3-                                              
HELIX    1   1 ALA A  117  LYS A  119  5                                   3    
SHEET    1   A 2 LEU A  28  CYS A  30  0                                        
SHEET    2   A 2 PHE A 146  PRO A 148 -1  N  LEU A 147   O  TYR A  29           
SHEET    1   B 2 PHE A  36  ILE A  39  0                                        
SHEET    2   B 2 VAL A  45  THR A  48 -1  N  THR A  48   O  PHE A  36           
SHEET    1   C 2 LEU A  79  MET A  81  0                                        
SHEET    2   C 2 LEU A  87  GLY A  89 -1  N  TYR A  88   O  ALA A  80           
SITE     1 AC1 10 GLY A 124  LYS A 126  LYS A 127  THR A 137                    
SITE     2 AC1 10 HIS A 138  TYR A 139  GLN A 141  LYS A 142                    
SITE     3 AC1 10 ALA A 143  ILE A 144                                          
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
MODEL        1                                                                  
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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