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Database: PDB
Entry: 1XPW
LinkDB: 1XPW
Original site: 1XPW 
HEADER    STRUCTURAL GENOMICS, UNKNOWN FUNCTION   09-OCT-04   1XPW              
TITLE     SOLUTION NMR STRUCTURE OF HUMAN PROTEIN HSPCO34. NORTHEAST            
TITLE    2 STRUCTURAL GENOMICS TARGET HR1958                                    
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: LOC51668 PROTEIN;                                          
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: HSPC034;                                                    
COMPND   5 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: PP25;                                                          
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21 (LAMDA DE3) PMGK;                     
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PET14                                     
KEYWDS    GENE PP25, LOCUS LOC51668, C1ORF41, HOMO SAPIENS, NESGC               
KEYWDS   2 CLUSTER ID 3237, TARGET HR1958, STRUCTURAL GENOMICS, APC10-          
KEYWDS   3 RELATED PROTEIN, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM,           
KEYWDS   4 PROTEIN STRUCTURE INITIATIVE, PSI, JELLYROLL, BETA-                  
KEYWDS   5 SANDWICH, UNKNOWN FUNCTION                                           
EXPDTA    SOLUTION NMR                                                          
NUMMDL    20                                                                    
AUTHOR    T.A.RAMELOT,R.XIAO,L.C.MA,T.B.ACTON,G.T.MONTELIONE,                   
AUTHOR   2 M.A.KENNEDY,NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG)          
REVDAT   5   09-JUN-09 1XPW    1       JRNL                                     
REVDAT   4   24-FEB-09 1XPW    1       VERSN                                    
REVDAT   3   12-JUL-05 1XPW    1       REMARK MASTER                            
REVDAT   2   25-JAN-05 1XPW    1       AUTHOR REMARK                            
REVDAT   1   09-NOV-04 1XPW    0                                                
JRNL        AUTH   T.A.RAMELOT,S.RAMAN,A.P.KUZIN,R.XIAO,L.C.MA,                 
JRNL        AUTH 2 T.B.ACTON,J.F.HUNT,G.T.MONTELIONE,D.BAKER,                   
JRNL        AUTH 3 M.A.KENNEDY                                                  
JRNL        TITL   IMPROVING NMR PROTEIN STRUCTURE QUALITY BY ROSETTA           
JRNL        TITL 2 REFINEMENT: A MOLECULAR REPLACEMENT STUDY.                   
JRNL        REF    PROTEINS                      V.  75   147 2009              
JRNL        REFN                   ISSN 0887-3585                               
JRNL        PMID   18816799                                                     
JRNL        DOI    10.1002/PROT.22229                                           
REMARK   1                                                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION. NOT APPLICABLE.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : CNS 1.1                                              
REMARK   3   AUTHORS     : BRUNGER                                              
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: THE UNSTRUCTURED 10 RESIDUE N-            
REMARK   3  TERMINAL HIS TAG (MGHHHHHHSH) WAS NOT INCLUDED IN THE               
REMARK   3  STRUCTURE CALCULATION.                                              
REMARK   4                                                                      
REMARK   4 1XPW COMPLIES WITH FORMAT V. 3.15, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 26-OCT-04.                  
REMARK 100 THE RCSB ID CODE IS RCSB030626.                                      
REMARK 210                                                                      
REMARK 210 EXPERIMENTAL DETAILS                                                 
REMARK 210  EXPERIMENT TYPE                : NMR                                
REMARK 210  TEMPERATURE           (KELVIN) : 298                                
REMARK 210  PH                             : 6.5                                
REMARK 210  IONIC STRENGTH                 : 100 MM NACL                        
REMARK 210  PRESSURE                       : AMBIENT                            
REMARK 210  SAMPLE CONTENTS                : 1 MM U-15N,13C PROTEIN, 20 MM      
REMARK 210                                   MES, 100 MM NACL, 10 MM DTT, 5     
REMARK 210                                   MM CACL2, 0.02% NAN3, 95% H2O,     
REMARK 210                                   5% D2O; 1 MM U-15N,13C             
REMARK 210                                   PROTEIN, 20 MM MES, 100 MM         
REMARK 210                                   NACL, 10 MM DTT, 5 MM CACL2,       
REMARK 210                                   0.02% NAN3, 100% D2O; 1 MM U-      
REMARK 210                                   15N,5%-13C PROTEIN, 20 MM MES,     
REMARK 210                                   100 MM NACL, 10 MM DTT, 5 MM       
REMARK 210                                   CACL2, 0.02% NAN3, 95% H2O, 5%     
REMARK 210                                   D2O                                
REMARK 210                                                                      
REMARK 210  NMR EXPERIMENTS CONDUCTED      : 3D_15N-SEPARATED_NOESY; 3D_        
REMARK 210                                   13C-SEPARATED_NOESY; HNHA;         
REMARK 210                                   13C_HSQC; 4D_13C-SEPARATED_        
REMARK 210                                   NOESY; H/D EXCHANGE                
REMARK 210  SPECTROMETER FIELD STRENGTH    : 800 MHZ; 750 MHZ; 600 MHZ          
REMARK 210  SPECTROMETER MODEL             : INOVA; UNITY                       
REMARK 210  SPECTROMETER MANUFACTURER      : VARIAN                             
REMARK 210                                                                      
REMARK 210  STRUCTURE DETERMINATION.                                            
REMARK 210   SOFTWARE USED                 : NMRPIPE NMRPIPE.LINUX, FELIX       
REMARK 210                                   98, AUTOSTRUCTURE 2.1.0, X-        
REMARK 210                                   PLOR XPLOR-NIH-2.0.6, SPARKY       
REMARK 210                                   3.106                              
REMARK 210   METHOD USED                   : XPLOR SIMULATED ANNEALING,         
REMARK 210                                   CNS WATER REFINEMENT               
REMARK 210                                                                      
REMARK 210 CONFORMERS, NUMBER CALCULATED   : 25                                 
REMARK 210 CONFORMERS, NUMBER SUBMITTED    : 20                                 
REMARK 210 CONFORMERS, SELECTION CRITERIA  : STRUCTURES WITH THE LEAST          
REMARK 210                                   RESTRAINT VIOLATIONS               
REMARK 210                                                                      
REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : 1                   
REMARK 210                                                                      
REMARK 210 REMARK: NULL                                                         
REMARK 215                                                                      
REMARK 215 NMR STUDY                                                            
REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION           
REMARK 215 NMR DATA.  PROTEIN DATA BANK CONVENTIONS REQUIRE THAT                
REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON              
REMARK 215 THESE RECORDS ARE MEANINGLESS.                                       
REMARK 400                                                                      
REMARK 400 COMPOUND                                                             
REMARK 400 THIS PROTEIN HAS STOICHIOMETRIC CALCIUM BOUND. CALCIUM               
REMARK 400 COORDINATION COULD NOT BE DETERMINED, BUT IS CONSISTENT              
REMARK 400 WITH PDB ENTRY 1TVG                                                  
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (RES=RESIDUE NAME; C=CHAIN IDENTIFIER;                   
REMARK 465 SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                            
REMARK 465   MODELS 1-20                                                        
REMARK 465     RES C SSSEQI                                                     
REMARK 465     MET A    -9                                                      
REMARK 465     GLY A    -8                                                      
REMARK 465     HIS A    -7                                                      
REMARK 465     HIS A    -6                                                      
REMARK 465     HIS A    -5                                                      
REMARK 465     HIS A    -4                                                      
REMARK 465     HIS A    -3                                                      
REMARK 465     HIS A    -2                                                      
REMARK 465     SER A    -1                                                      
REMARK 465     HIS A     0                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500  1 ARG A   2     -170.91     61.58                                   
REMARK 500  1 LYS A   3       70.82     53.15                                   
REMARK 500  1 HIS A  25       74.61   -111.04                                   
REMARK 500  1 PHE A  68      -23.55     73.38                                   
REMARK 500  1 PRO A  82       46.11    -70.10                                   
REMARK 500  1 ASP A  84       84.48     57.25                                   
REMARK 500  1 TRP A  88      -68.93    -96.16                                   
REMARK 500  1 HIS A  95      106.67    -57.05                                   
REMARK 500  2 ARG A   2       23.48   -167.35                                   
REMARK 500  2 LEU A  17       90.28     70.34                                   
REMARK 500  2 ILE A  31      -87.13   -107.96                                   
REMARK 500  2 ASP A  32      -46.14     69.27                                   
REMARK 500  2 THR A  42       36.36    -89.52                                   
REMARK 500  2 PHE A  68      -96.75     65.48                                   
REMARK 500  2 VAL A  69     -168.28     55.90                                   
REMARK 500  2 GLN A  70      -68.32    177.44                                   
REMARK 500  2 PRO A  82       34.43    -77.99                                   
REMARK 500  2 ASP A  84       98.15     61.55                                   
REMARK 500  2 TRP A  88      -79.46   -130.83                                   
REMARK 500  2 LEU A 141       54.22    -93.58                                   
REMARK 500  3 LEU A  17      131.85     73.97                                   
REMARK 500  3 PHE A  68      -93.25     69.32                                   
REMARK 500  3 VAL A  69     -158.42     52.65                                   
REMARK 500  3 GLN A  70      -72.76    177.53                                   
REMARK 500  3 LYS A  80      -49.29     71.81                                   
REMARK 500  3 TRP A  88      -74.11   -100.75                                   
REMARK 500  3 VAL A 138      -71.89    -89.84                                   
REMARK 500  3 LEU A 141       46.29    -93.85                                   
REMARK 500  4 LYS A   3       89.43     70.46                                   
REMARK 500  4 LEU A  17       80.11     62.14                                   
REMARK 500  4 ASP A  32      -67.82   -101.26                                   
REMARK 500  4 HIS A  54       -2.51     67.59                                   
REMARK 500  4 GLN A  70      -88.17   -113.20                                   
REMARK 500  4 PRO A  82       44.67    -75.39                                   
REMARK 500  4 ASP A  84       87.53     64.91                                   
REMARK 500  4 TRP A  88      -73.43    -75.46                                   
REMARK 500  4 ASN A 140     -164.70    -78.78                                   
REMARK 500  4 SER A 142      -49.95   -154.09                                   
REMARK 500  5 ARG A   2      124.56     68.79                                   
REMARK 500  5 LEU A  17      -89.98     73.20                                   
REMARK 500  5 ALA A  18       92.99     55.45                                   
REMARK 500  5 ILE A  31      -86.57   -118.90                                   
REMARK 500  5 ASP A  32      -51.16     68.70                                   
REMARK 500  5 HIS A  54       -5.62     69.35                                   
REMARK 500  5 PHE A  68      -25.90     77.14                                   
REMARK 500  5 GLN A  70      -63.65   -120.23                                   
REMARK 500  5 PRO A  82       38.01    -78.14                                   
REMARK 500  5 ASP A  84       80.45     64.15                                   
REMARK 500  5 TRP A  88      -72.80    -92.96                                   
REMARK 500  5 SER A 130      142.10   -171.11                                   
REMARK 500  6 LEU A  17       84.40     61.99                                   
REMARK 500  6 THR A  42       45.80    -82.88                                   
REMARK 500  6 GLU A  48      119.67   -164.37                                   
REMARK 500  6 HIS A  54      -17.18     70.76                                   
REMARK 500  6 GLN A  70      -85.72    -95.49                                   
REMARK 500  6 PRO A  82       45.70    -77.70                                   
REMARK 500  6 VAL A  83     -162.57   -122.13                                   
REMARK 500  6 ASP A  84      -74.78     73.68                                   
REMARK 500  6 PHE A  85       90.57     59.58                                   
REMARK 500  6 TRP A  88      -79.09   -102.30                                   
REMARK 500  7 LYS A   3      106.75     69.64                                   
REMARK 500  7 LEU A  17      -94.70     69.33                                   
REMARK 500  7 ALA A  18      116.68     62.98                                   
REMARK 500  7 ILE A  31     -104.18   -109.25                                   
REMARK 500  7 ASP A  32      -53.85     69.09                                   
REMARK 500  7 PHE A  68      -31.46     75.99                                   
REMARK 500  7 GLN A  70      -78.25   -115.91                                   
REMARK 500  7 PRO A  82       35.54    -74.24                                   
REMARK 500  7 ASP A  84       93.82     61.14                                   
REMARK 500  7 TRP A  88      -83.67   -102.94                                   
REMARK 500  7 SER A 142      -47.48   -154.73                                   
REMARK 500  8 LEU A  17      -82.15     75.76                                   
REMARK 500  8 ALA A  18       90.68     51.46                                   
REMARK 500  8 PHE A  68      -23.93     76.58                                   
REMARK 500  8 GLN A  70      -81.39    -95.17                                   
REMARK 500  8 PRO A  82       32.91    -79.05                                   
REMARK 500  8 ASP A  84       73.75     58.31                                   
REMARK 500  8 GLN A  87       99.58    -64.23                                   
REMARK 500  8 TRP A  88      -82.45    -87.36                                   
REMARK 500  8 ASN A 140     -100.11    -77.48                                   
REMARK 500  8 SER A 142       95.79    -65.74                                   
REMARK 500  9 LEU A  17      -90.56     74.02                                   
REMARK 500  9 ALA A  18       93.07     54.09                                   
REMARK 500  9 PRO A  27        5.66    -68.79                                   
REMARK 500  9 PHE A  68      -99.64     67.39                                   
REMARK 500  9 VAL A  69     -151.05     48.95                                   
REMARK 500  9 GLN A  70      -73.44    172.68                                   
REMARK 500  9 PRO A  82       36.89    -76.79                                   
REMARK 500  9 ASP A  84      100.03     65.31                                   
REMARK 500  9 TRP A  88      -74.78   -130.98                                   
REMARK 500 10 ARG A   2      -26.58   -142.77                                   
REMARK 500 10 LEU A  17      -88.59     73.67                                   
REMARK 500 10 ALA A  18       94.03     56.18                                   
REMARK 500 10 ILE A  31     -106.73   -111.93                                   
REMARK 500 10 ASP A  32      -51.80     71.93                                   
REMARK 500 10 GLU A  36      -65.11    -90.42                                   
REMARK 500 10 THR A  42       39.25    -81.62                                   
REMARK 500 10 PHE A  68      -99.96     65.70                                   
REMARK 500 10 VAL A  69       93.54     48.34                                   
REMARK 500 10 PRO A  82       45.35    -70.22                                   
REMARK 500 10 ASP A  84       88.83     66.41                                   
REMARK 500 10 HIS A 129      -65.03    -91.25                                   
REMARK 500 10 ASN A 140     -177.08    -68.77                                   
REMARK 500 10 SER A 142       18.74   -145.82                                   
REMARK 500 11 ASP A   5       96.84    -64.95                                   
REMARK 500 11 LEU A  17     -101.34     76.16                                   
REMARK 500 11 ALA A  18      111.34     59.48                                   
REMARK 500 11 PRO A  27        5.60    -67.84                                   
REMARK 500 11 ILE A  31      -96.21   -137.93                                   
REMARK 500 11 ASP A  32      -53.65     68.43                                   
REMARK 500 11 PHE A  68     -137.00     64.27                                   
REMARK 500 11 VAL A  69      121.79     71.58                                   
REMARK 500 11 GLN A  70      -72.59    -97.45                                   
REMARK 500 11 PRO A  82       44.72    -70.13                                   
REMARK 500 11 TRP A  88      -67.26    -94.61                                   
REMARK 500 11 ASN A 140     -165.71    -76.95                                   
REMARK 500 12 LEU A  17      -90.72     71.80                                   
REMARK 500 12 ALA A  18       99.56     52.42                                   
REMARK 500 12 ILE A  31      -91.42    -84.05                                   
REMARK 500 12 ASP A  32      -51.18     74.26                                   
REMARK 500 12 PHE A  68      -10.75     72.39                                   
REMARK 500 12 ASP A  84       85.85     61.78                                   
REMARK 500 12 HIS A 129      -63.70   -131.13                                   
REMARK 500 12 SER A 142       17.41   -146.63                                   
REMARK 500 13 LEU A  17       94.18     67.38                                   
REMARK 500 13 PHE A  68      -23.38     75.17                                   
REMARK 500 13 PRO A  82       45.97    -74.62                                   
REMARK 500 13 ASP A  84       97.59     63.78                                   
REMARK 500 13 TRP A  88      -72.75   -118.92                                   
REMARK 500 13 GLN A 101       97.68    -69.55                                   
REMARK 500 13 HIS A 129      -50.48   -130.18                                   
REMARK 500 14 PHE A  68      -96.78     65.00                                   
REMARK 500 14 VAL A  69     -174.83     58.20                                   
REMARK 500 14 GLN A  70      -69.84   -172.70                                   
REMARK 500 14 PRO A  82       32.65    -83.62                                   
REMARK 500 14 ASP A  84      105.86     63.17                                   
REMARK 500 14 TRP A  88      -78.60    -90.93                                   
REMARK 500 15 ASP A  32      -64.91   -109.60                                   
REMARK 500 15 GLN A  70      -76.93   -111.39                                   
REMARK 500 15 PRO A  82       43.05    -75.07                                   
REMARK 500 15 ASP A  84      106.76     63.45                                   
REMARK 500 16 ARG A   2     -161.79   -120.31                                   
REMARK 500 16 LYS A   3       61.58     68.17                                   
REMARK 500 16 LEU A  17      118.84     71.00                                   
REMARK 500 16 HIS A  54      -17.73     71.00                                   
REMARK 500 16 PHE A  68      -10.79     72.92                                   
REMARK 500 16 GLN A  70      -74.02   -113.25                                   
REMARK 500 16 ASP A  84       88.79     58.00                                   
REMARK 500 16 HIS A 129      -60.35    -98.27                                   
REMARK 500 17 LEU A  17       99.70     69.45                                   
REMARK 500 17 PHE A  68      -84.99     67.85                                   
REMARK 500 17 VAL A  69     -160.92     56.33                                   
REMARK 500 17 GLN A  70      -77.47   -174.22                                   
REMARK 500 17 PRO A  82       46.46    -70.86                                   
REMARK 500 17 ASP A  84       93.10     61.55                                   
REMARK 500 17 TRP A  88      -65.38    -97.11                                   
REMARK 500 18 LEU A  17      -87.68     72.24                                   
REMARK 500 18 ALA A  18       94.94     52.75                                   
REMARK 500 18 MET A  44       74.10   -105.72                                   
REMARK 500 18 PHE A  68       87.16     57.45                                   
REMARK 500 18 VAL A  69     -165.76   -118.67                                   
REMARK 500 18 GLN A  70      -95.34   -163.37                                   
REMARK 500 18 PRO A  82       35.57    -82.08                                   
REMARK 500 18 ASP A  84      101.65     64.43                                   
REMARK 500 18 TRP A  88      -69.62    -97.55                                   
REMARK 500 19 LEU A  17      100.72     69.78                                   
REMARK 500 19 PHE A  68       -2.68     72.37                                   
REMARK 500 19 GLN A  70      -72.74   -104.09                                   
REMARK 500 19 PRO A  82       46.24    -74.28                                   
REMARK 500 19 ASP A  84       77.14     55.39                                   
REMARK 500 19 TRP A  88      -71.46   -102.40                                   
REMARK 500 19 ASN A 140      -88.66    -96.88                                   
REMARK 500 20 LEU A  17       91.77     65.65                                   
REMARK 500 20 GLU A  36      -70.18    -81.62                                   
REMARK 500 20 HIS A  54      -17.15     72.53                                   
REMARK 500 20 PHE A  68     -100.92     67.56                                   
REMARK 500 20 VAL A  69     -168.77     55.89                                   
REMARK 500 20 GLN A  70      -71.99   -170.11                                   
REMARK 500 20 PRO A  82       42.87    -82.86                                   
REMARK 500 20 ASP A  84       92.96     58.36                                   
REMARK 500 20 ASN A 140     -153.60    -91.36                                   
REMARK 500 20 LEU A 141       91.99    -68.87                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 1TVG   RELATED DB: PDB                                   
REMARK 900 X-RAY CRYSTAL STRUCTURE OF IDENTICAL PROTEIN                         
REMARK 900 RELATED ID: HR1958   RELATED DB: TARGETDB                            
DBREF  1XPW A    1   143  UNP    Q9Y547   Q9Y547_HUMAN     1    144             
SEQADV 1XPW MET A   -9  UNP  Q9Y547              EXPRESSION TAG                 
SEQADV 1XPW GLY A   -8  UNP  Q9Y547              EXPRESSION TAG                 
SEQADV 1XPW HIS A   -7  UNP  Q9Y547              EXPRESSION TAG                 
SEQADV 1XPW HIS A   -6  UNP  Q9Y547              EXPRESSION TAG                 
SEQADV 1XPW HIS A   -5  UNP  Q9Y547              EXPRESSION TAG                 
SEQADV 1XPW HIS A   -4  UNP  Q9Y547              EXPRESSION TAG                 
SEQADV 1XPW HIS A   -3  UNP  Q9Y547              EXPRESSION TAG                 
SEQADV 1XPW HIS A   -2  UNP  Q9Y547              EXPRESSION TAG                 
SEQADV 1XPW SER A   -1  UNP  Q9Y547              EXPRESSION TAG                 
SEQADV 1XPW HIS A    0  UNP  Q9Y547              EXPRESSION TAG                 
SEQADV 1XPW     A       UNP  Q9Y547    ASP   109 DELETION                       
SEQRES   1 A  153  MET GLY HIS HIS HIS HIS HIS HIS SER HIS MET ARG LYS          
SEQRES   2 A  153  ILE ASP LEU CYS LEU SER SER GLU GLY SER GLU VAL ILE          
SEQRES   3 A  153  LEU ALA THR SER SER ASP GLU LYS HIS PRO PRO GLU ASN          
SEQRES   4 A  153  ILE ILE ASP GLY ASN PRO GLU THR PHE TRP THR THR THR          
SEQRES   5 A  153  GLY MET PHE PRO GLN GLU PHE ILE ILE CYS PHE HIS LYS          
SEQRES   6 A  153  HIS VAL ARG ILE GLU ARG LEU VAL ILE GLN SER TYR PHE          
SEQRES   7 A  153  VAL GLN THR LEU LYS ILE GLU LYS SER THR SER LYS GLU          
SEQRES   8 A  153  PRO VAL ASP PHE GLU GLN TRP ILE GLU LYS ASP LEU VAL          
SEQRES   9 A  153  HIS THR GLU GLY GLN LEU GLN ASN GLU GLU ILE VAL ALA          
SEQRES  10 A  153  HIS GLY SER ALA THR TYR LEU ARG PHE ILE ILE VAL SER          
SEQRES  11 A  153  ALA PHE ASP HIS PHE ALA SER VAL HIS SER VAL SER ALA          
SEQRES  12 A  153  GLU GLY THR VAL VAL SER ASN LEU SER SER                      
HELIX    1   1 LEU A    8  GLY A   12  5                                   5    
HELIX    2   2 PRO A   26  ILE A   30  5                                   5    
SHEET    1   A 4 ILE A   4  ASP A   5  0                                        
SHEET    2   A 4 SER A 127  SER A 139 -1  O  GLY A 135   N  ILE A   4           
SHEET    3   A 4 GLN A  47  TYR A  67 -1  N  GLN A  65   O  SER A 130           
SHEET    4   A 4 GLU A  14  ILE A  16 -1  N  ILE A  16   O  ILE A  50           
SHEET    1   B 4 TRP A  39  THR A  40  0                                        
SHEET    2   B 4 SER A 127  SER A 139 -1  O  VAL A 128   N  TRP A  39           
SHEET    3   B 4 GLN A  47  TYR A  67 -1  N  GLN A  65   O  SER A 130           
SHEET    4   B 4 GLN A 101  ILE A 105 -1  O  GLU A 103   N  ILE A  64           
SHEET    1   C 6 ILE A   4  ASP A   5  0                                        
SHEET    2   C 6 SER A 127  SER A 139 -1  O  GLY A 135   N  ILE A   4           
SHEET    3   C 6 GLN A  47  TYR A  67 -1  N  GLN A  65   O  SER A 130           
SHEET    4   C 6 GLY A 109  ILE A 118 -1  O  ILE A 118   N  GLN A  47           
SHEET    5   C 6 THR A  71  SER A  77 -1  N  SER A  77   O  THR A 112           
SHEET    6   C 6 GLU A  86  ASP A  92 -1  O  GLU A  86   N  LYS A  76           
CISPEP   1 PHE A   45    PRO A   46          1        -1.77                     
CISPEP   2 PHE A   45    PRO A   46          2        -1.61                     
CISPEP   3 PHE A   45    PRO A   46          3        -0.22                     
CISPEP   4 PHE A   45    PRO A   46          4        -1.73                     
CISPEP   5 PHE A   45    PRO A   46          5        -1.87                     
CISPEP   6 PHE A   45    PRO A   46          6        -2.13                     
CISPEP   7 PHE A   45    PRO A   46          7        -3.34                     
CISPEP   8 PHE A   45    PRO A   46          8        -1.00                     
CISPEP   9 PHE A   45    PRO A   46          9        -0.59                     
CISPEP  10 PHE A   45    PRO A   46         10        -1.82                     
CISPEP  11 PHE A   45    PRO A   46         11        -0.40                     
CISPEP  12 PHE A   45    PRO A   46         12        -0.17                     
CISPEP  13 PHE A   45    PRO A   46         13        -0.31                     
CISPEP  14 PHE A   45    PRO A   46         14        -2.74                     
CISPEP  15 PHE A   45    PRO A   46         15        -1.41                     
CISPEP  16 PHE A   45    PRO A   46         16        -0.09                     
CISPEP  17 PHE A   45    PRO A   46         17         0.86                     
CISPEP  18 PHE A   45    PRO A   46         18        -0.77                     
CISPEP  19 PHE A   45    PRO A   46         19         1.20                     
CISPEP  20 PHE A   45    PRO A   46         20        -1.28                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
MODEL        1                                                                  
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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