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Database: PDB
Entry: 1ZGL
LinkDB: 1ZGL
Original site: 1ZGL 
HEADER    IMMUNE SYSTEM                           21-APR-05   1ZGL              
TITLE     CRYSTAL STRUCTURE OF 3A6 TCR BOUND TO MBP/HLA-DR2A                    
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN;   
COMPND   3 CHAIN: A, D, G, J;                                                   
COMPND   4 SYNONYM: MHC CLASS II ANTIGEN DRA;                                   
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS II, DR BETA 5;     
COMPND   8 CHAIN: B, E, H, K;                                                   
COMPND   9 ENGINEERED: YES;                                                     
COMPND  10 MOL_ID: 3;                                                           
COMPND  11 MOLECULE: MYELIN BASIC PROTEIN;                                      
COMPND  12 CHAIN: C, F, I, L;                                                   
COMPND  13 SYNONYM: MBP;                                                        
COMPND  14 ENGINEERED: YES;                                                     
COMPND  15 MOL_ID: 4;                                                           
COMPND  16 MOLECULE: T CELL RECEPTOR ALPHA CHAIN;                               
COMPND  17 CHAIN: M, Q, S, U;                                                   
COMPND  18 ENGINEERED: YES;                                                     
COMPND  19 MOL_ID: 5;                                                           
COMPND  20 MOLECULE: T CELL RECEPTOR BETA CHAIN;                                
COMPND  21 CHAIN: P, R, T, V;                                                   
COMPND  22 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: HLA-DRA;                                                       
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE   9 EXPRESSION_SYSTEM_PLASMID: PET-26B;                                  
SOURCE  10 MOL_ID: 2;                                                           
SOURCE  11 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  12 ORGANISM_COMMON: HUMAN;                                              
SOURCE  13 ORGANISM_TAXID: 9606;                                                
SOURCE  14 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  15 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  16 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  17 EXPRESSION_SYSTEM_PLASMID: PET-26B;                                  
SOURCE  18 MOL_ID: 3;                                                           
SOURCE  19 SYNTHETIC: YES;                                                      
SOURCE  20 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  21 ORGANISM_TAXID: 9606;                                                
SOURCE  22 MOL_ID: 4;                                                           
SOURCE  23 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  24 ORGANISM_COMMON: HUMAN;                                              
SOURCE  25 ORGANISM_TAXID: 9606;                                                
SOURCE  26 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  27 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  28 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  29 EXPRESSION_SYSTEM_PLASMID: PET-26B;                                  
SOURCE  30 MOL_ID: 5;                                                           
SOURCE  31 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  32 ORGANISM_COMMON: HUMAN;                                              
SOURCE  33 ORGANISM_TAXID: 9606;                                                
SOURCE  34 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  35 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  36 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  37 EXPRESSION_SYSTEM_PLASMID: PET-26B                                   
KEYWDS    TCR-PEPTIDE-MHC COMPLEX, IMMUNE SYSTEM                                
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    Y.LI,Y.HUANG,J.LUE,J.A.QUANDT,R.MARTIN,R.A.MARIUZZA                   
REVDAT   4   19-FEB-20 1ZGL    1       COMPND SOURCE REMARK SEQADV              
REVDAT   3   11-OCT-17 1ZGL    1       REMARK                                   
REVDAT   2   24-FEB-09 1ZGL    1       VERSN                                    
REVDAT   1   18-OCT-05 1ZGL    0                                                
JRNL        AUTH   Y.LI,Y.HUANG,J.LUE,J.A.QUANDT,R.MARTIN,R.A.MARIUZZA          
JRNL        TITL   STRUCTURE OF A HUMAN AUTOIMMUNE TCR BOUND TO A MYELIN BASIC  
JRNL        TITL 2 PROTEIN SELF-PEPTIDE AND A MULTIPLE SCLEROSIS-ASSOCIATED MHC 
JRNL        TITL 3 CLASS II MOLECULE.                                           
JRNL        REF    EMBO J.                       V.  24  2968 2005              
JRNL        REFN                   ISSN 0261-4189                               
JRNL        PMID   16079912                                                     
JRNL        DOI    10.1038/SJ.EMBOJ.7600771                                     
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.80 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : CNS                                                  
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-              
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES,PANNU,              
REMARK   3               : READ,RICE,SIMONSON,WARREN                            
REMARK   3                                                                      
REMARK   3  REFINEMENT TARGET : ENGH & HUBER                                    
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.80                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 30.00                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000                          
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : NULL                           
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : NULL                           
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : 86.4                           
REMARK   3   NUMBER OF REFLECTIONS             : 81551                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : NULL                            
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE            (WORKING SET) : 0.280                           
REMARK   3   FREE R VALUE                     : 0.329                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : NULL                            
REMARK   3   FREE R VALUE TEST SET COUNT      : 1617                            
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : NULL                            
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : NULL                         
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : NULL                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : NULL                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : NULL                         
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : NULL                         
REMARK   3   BIN R VALUE           (WORKING SET) : NULL                         
REMARK   3   BIN FREE R VALUE                    : NULL                         
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : NULL                         
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : NULL                         
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : NULL                         
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 23456                                   
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 0                                       
REMARK   3   SOLVENT ATOMS            : 0                                       
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  ESTIMATED COORDINATE ERROR.                                         
REMARK   3   ESD FROM LUZZATI PLOT        (A) : NULL                            
REMARK   3   ESD FROM SIGMAA              (A) : NULL                            
REMARK   3   LOW RESOLUTION CUTOFF        (A) : NULL                            
REMARK   3                                                                      
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.                         
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : NULL                            
REMARK   3   ESD FROM C-V SIGMAA          (A) : NULL                            
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.                                   
REMARK   3   BOND LENGTHS                 (A) : NULL                            
REMARK   3   BOND ANGLES            (DEGREES) : NULL                            
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : NULL                            
REMARK   3   IMPROPER ANGLES        (DEGREES) : NULL                            
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL MODEL : NULL                                      
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA                
REMARK   3   MAIN-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELING.                                              
REMARK   3   METHOD USED : NULL                                                 
REMARK   3   KSOL        : NULL                                                 
REMARK   3   BSOL        : NULL                                                 
REMARK   3                                                                      
REMARK   3  NCS MODEL : NULL                                                    
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT          
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL                 
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  PARAMETER FILE  1  : NULL                                           
REMARK   3  TOPOLOGY FILE  1   : NULL                                           
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 1ZGL COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 12-OCT-05.                  
REMARK 100 THE DEPOSITION ID IS D_1000032696.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 01-OCT-04                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : NULL                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : N                                  
REMARK 200  RADIATION SOURCE               : ROTATING ANODE                     
REMARK 200  BEAMLINE                       : NULL                               
REMARK 200  X-RAY GENERATOR MODEL          : RIGAKU                             
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.5418                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : AREA DETECTOR                      
REMARK 200  DETECTOR MANUFACTURER          : SIEMENS HI-STAR                    
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : R-AXIS                             
REMARK 200  DATA SCALING SOFTWARE          : R-AXIS                             
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 81551                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.800                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 30.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 5.900                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 0.9                                
REMARK 200  DATA REDUNDANCY                : NULL                               
REMARK 200  R MERGE                    (I) : 0.08000                            
REMARK 200  R SYM                      (I) : 0.08000                            
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : NULL                               
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.80                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.92                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 86.5                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.28400                            
REMARK 200  R SYM FOR SHELL            (I) : 0.28400                            
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 2.500                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: AMORE                                                 
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 52.29                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.58                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: NULL                                     
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1                              
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2, 3, 4                                              
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: PENTAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, M, P                         
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: PENTAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D, E, F, Q, R                         
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 3                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: PENTAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G, H, I, S, T                         
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 4                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: PENTAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: J, K, L, U, V                         
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     ILE A     1                                                      
REMARK 465     LYS A     2                                                      
REMARK 465     GLU A     3                                                      
REMARK 465     ALA B   104                                                      
REMARK 465     GLN B   107                                                      
REMARK 465     THR B   108                                                      
REMARK 465     LEU B   109                                                      
REMARK 465     GLN B   110                                                      
REMARK 465     HIS B   111                                                      
REMARK 465     HIS B   112                                                      
REMARK 465     ARG B   133                                                      
REMARK 465     GLN B   136                                                      
REMARK 465     GLU B   137                                                      
REMARK 465     GLU B   138                                                      
REMARK 465     LYS B   139                                                      
REMARK 465     ALA B   140                                                      
REMARK 465     GLY B   141                                                      
REMARK 465     ALA B   190                                                      
REMARK 465     GLN B   191                                                      
REMARK 465     SER B   192                                                      
REMARK 465     GLY C    15                                                      
REMARK 465     GLY M     0                                                      
REMARK 465     ILE M   118                                                      
REMARK 465     GLN M   119                                                      
REMARK 465     ALA M   124                                                      
REMARK 465     GLN M   127                                                      
REMARK 465     LEU M   128                                                      
REMARK 465     ARG M   129                                                      
REMARK 465     ASP M   130                                                      
REMARK 465     SER M   131                                                      
REMARK 465     LYS M   132                                                      
REMARK 465     SER M   133                                                      
REMARK 465     SER M   134                                                      
REMARK 465     ASP M   135                                                      
REMARK 465     LYS M   136                                                      
REMARK 465     VAL M   150                                                      
REMARK 465     SER M   151                                                      
REMARK 465     GLN M   152                                                      
REMARK 465     SER M   153                                                      
REMARK 465     LYS M   154                                                      
REMARK 465     ASP M   155                                                      
REMARK 465     SER M   156                                                      
REMARK 465     LYS M   184                                                      
REMARK 465     PHE M   204                                                      
REMARK 465     PRO M   205                                                      
REMARK 465     SER M   206                                                      
REMARK 465     PRO M   207                                                      
REMARK 465     GLU M   208                                                      
REMARK 465     SER M   209                                                      
REMARK 465     SER M   210                                                      
REMARK 465     CYS M   211                                                      
REMARK 465     ALA M   212                                                      
REMARK 465     LYS P   143                                                      
REMARK 465     ARG P   245                                                      
REMARK 465     ALA P   246                                                      
REMARK 465     ASP P   247                                                      
REMARK 465     CYS P   248                                                      
REMARK 465     ALA P   249                                                      
REMARK 465     ALA P   250                                                      
REMARK 465     ILE D     1                                                      
REMARK 465     LYS D     2                                                      
REMARK 465     GLU D     3                                                      
REMARK 465     GLY E     1                                                      
REMARK 465     ALA E   104                                                      
REMARK 465     GLN E   107                                                      
REMARK 465     THR E   108                                                      
REMARK 465     LEU E   109                                                      
REMARK 465     GLN E   110                                                      
REMARK 465     HIS E   111                                                      
REMARK 465     HIS E   112                                                      
REMARK 465     GLU E   138                                                      
REMARK 465     LYS E   139                                                      
REMARK 465     ALA E   140                                                      
REMARK 465     GLY E   141                                                      
REMARK 465     THR E   163                                                      
REMARK 465     VAL E   164                                                      
REMARK 465     ALA E   190                                                      
REMARK 465     GLN E   191                                                      
REMARK 465     SER E   192                                                      
REMARK 465     ASP Q   117                                                      
REMARK 465     ILE Q   118                                                      
REMARK 465     GLN Q   119                                                      
REMARK 465     ALA Q   124                                                      
REMARK 465     GLN Q   127                                                      
REMARK 465     LYS Q   132                                                      
REMARK 465     SER Q   133                                                      
REMARK 465     SER Q   134                                                      
REMARK 465     ASP Q   135                                                      
REMARK 465     LYS Q   136                                                      
REMARK 465     LYS Q   154                                                      
REMARK 465     ASP Q   155                                                      
REMARK 465     SER Q   156                                                      
REMARK 465     PHE Q   204                                                      
REMARK 465     PRO Q   205                                                      
REMARK 465     SER Q   206                                                      
REMARK 465     PRO Q   207                                                      
REMARK 465     GLU Q   208                                                      
REMARK 465     SER Q   209                                                      
REMARK 465     SER Q   210                                                      
REMARK 465     CYS Q   211                                                      
REMARK 465     ALA Q   212                                                      
REMARK 465     GLY R    -1                                                      
REMARK 465     GLU R   241                                                      
REMARK 465     ALA R   242                                                      
REMARK 465     TRP R   243                                                      
REMARK 465     GLY R   244                                                      
REMARK 465     ARG R   245                                                      
REMARK 465     ALA R   246                                                      
REMARK 465     ASP R   247                                                      
REMARK 465     CYS R   248                                                      
REMARK 465     ALA R   249                                                      
REMARK 465     ALA R   250                                                      
REMARK 465     ILE G     1                                                      
REMARK 465     LYS G     2                                                      
REMARK 465     GLU G     3                                                      
REMARK 465     ARG H   105                                                      
REMARK 465     THR H   106                                                      
REMARK 465     GLN H   107                                                      
REMARK 465     THR H   108                                                      
REMARK 465     LEU H   109                                                      
REMARK 465     GLN H   110                                                      
REMARK 465     HIS H   111                                                      
REMARK 465     HIS H   112                                                      
REMARK 465     ARG H   133                                                      
REMARK 465     ASN H   134                                                      
REMARK 465     SER H   135                                                      
REMARK 465     GLN H   136                                                      
REMARK 465     GLU H   137                                                      
REMARK 465     GLU H   138                                                      
REMARK 465     LYS H   139                                                      
REMARK 465     ALA H   140                                                      
REMARK 465     GLY H   141                                                      
REMARK 465     THR H   163                                                      
REMARK 465     VAL H   164                                                      
REMARK 465     PRO H   165                                                      
REMARK 465     ARG H   166                                                      
REMARK 465     ALA H   190                                                      
REMARK 465     GLN H   191                                                      
REMARK 465     SER H   192                                                      
REMARK 465     VAL I     1                                                      
REMARK 465     GLY I    15                                                      
REMARK 465     GLY S     0                                                      
REMARK 465     ASP S   117                                                      
REMARK 465     ILE S   118                                                      
REMARK 465     ALA S   124                                                      
REMARK 465     GLN S   127                                                      
REMARK 465     LYS S   132                                                      
REMARK 465     SER S   133                                                      
REMARK 465     SER S   134                                                      
REMARK 465     ASP S   135                                                      
REMARK 465     LYS S   136                                                      
REMARK 465     SER S   137                                                      
REMARK 465     VAL S   138                                                      
REMARK 465     CYS S   139                                                      
REMARK 465     ASP S   143                                                      
REMARK 465     VAL S   150                                                      
REMARK 465     SER S   151                                                      
REMARK 465     GLN S   152                                                      
REMARK 465     SER S   156                                                      
REMARK 465     TRP S   181                                                      
REMARK 465     SER S   182                                                      
REMARK 465     ALA S   188                                                      
REMARK 465     CYS S   189                                                      
REMARK 465     ILE S   197                                                      
REMARK 465     ILE S   198                                                      
REMARK 465     PHE S   204                                                      
REMARK 465     PRO S   205                                                      
REMARK 465     SER S   206                                                      
REMARK 465     PRO S   207                                                      
REMARK 465     GLU S   208                                                      
REMARK 465     SER S   209                                                      
REMARK 465     SER S   210                                                      
REMARK 465     CYS S   211                                                      
REMARK 465     ALA S   212                                                      
REMARK 465     ALA T   129                                                      
REMARK 465     GLU T   132                                                      
REMARK 465     PRO T   133                                                      
REMARK 465     SER T   134                                                      
REMARK 465     GLU T   135                                                      
REMARK 465     ALA T   136                                                      
REMARK 465     LYS T   143                                                      
REMARK 465     GLY T   166                                                      
REMARK 465     LYS T   167                                                      
REMARK 465     GLU T   168                                                      
REMARK 465     LEU T   197                                                      
REMARK 465     ARG T   198                                                      
REMARK 465     VAL T   199                                                      
REMARK 465     SER T   200                                                      
REMARK 465     PHE T   203                                                      
REMARK 465     ASN T   209                                                      
REMARK 465     ALA T   240                                                      
REMARK 465     GLU T   241                                                      
REMARK 465     ALA T   242                                                      
REMARK 465     ARG T   245                                                      
REMARK 465     CYS T   248                                                      
REMARK 465     ALA T   249                                                      
REMARK 465     ALA T   250                                                      
REMARK 465     ILE J     1                                                      
REMARK 465     LYS J     2                                                      
REMARK 465     GLU J     3                                                      
REMARK 465     ALA K   104                                                      
REMARK 465     ARG K   105                                                      
REMARK 465     THR K   106                                                      
REMARK 465     GLN K   107                                                      
REMARK 465     THR K   108                                                      
REMARK 465     LEU K   109                                                      
REMARK 465     GLN K   110                                                      
REMARK 465     HIS K   111                                                      
REMARK 465     HIS K   112                                                      
REMARK 465     ALA K   190                                                      
REMARK 465     GLN K   191                                                      
REMARK 465     SER K   192                                                      
REMARK 465     GLY L    15                                                      
REMARK 465     ALA U   124                                                      
REMARK 465     SER U   133                                                      
REMARK 465     SER U   134                                                      
REMARK 465     ASP U   135                                                      
REMARK 465     LYS U   154                                                      
REMARK 465     ASP U   155                                                      
REMARK 465     SER U   156                                                      
REMARK 465     SER U   206                                                      
REMARK 465     PRO U   207                                                      
REMARK 465     GLU U   208                                                      
REMARK 465     SER U   209                                                      
REMARK 465     SER U   210                                                      
REMARK 465     CYS U   211                                                      
REMARK 465     ALA U   212                                                      
REMARK 465     GLY V    -1                                                      
REMARK 465     ARG V   245                                                      
REMARK 465     ALA V   246                                                      
REMARK 465     ASP V   247                                                      
REMARK 465     CYS V   248                                                      
REMARK 465     ALA V   249                                                      
REMARK 465     ALA V   250                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     GLU A   4    CG   CD   OE1  OE2                                  
REMARK 470     LYS A  39    CG   CD   CE   NZ                                   
REMARK 470     GLU A  40    CG   CD   OE1  OE2                                  
REMARK 470     GLU A  46    CG   CD   OE1  OE2                                  
REMARK 470     GLU A  47    CG   CD   OE1  OE2                                  
REMARK 470     LYS A  67    CG   CD   CE   NZ                                   
REMARK 470     GLU A  98    CG   CD   OE1  OE2                                  
REMARK 470     LEU A  99    CG   CD1  CD2                                       
REMARK 470     ARG A 100    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A 101    CG   CD   OE1  OE2                                  
REMARK 470     LEU A 105    CG   CD1  CD2                                       
REMARK 470     PHE A 108    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP A 110    OD1  OD2                                            
REMARK 470     LYS A 111    CG   CD   CE   NZ                                   
REMARK 470     ASN A 118    CG   OD1  ND2                                       
REMARK 470     ARG A 123    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 126    CG   CD   CE   NZ                                   
REMARK 470     THR A 135    OG1  CG2                                            
REMARK 470     GLU A 141    CG   CD   OE1  OE2                                  
REMARK 470     LEU A 151    CG   CD1  CD2                                       
REMARK 470     THR A 157    OG1  CG2                                            
REMARK 470     GLU A 158    CG   CD   OE1  OE2                                  
REMARK 470     VAL A 160    CG1  CG2                                            
REMARK 470     ARG A 164    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A 172    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 179    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 181    CG   OD1  OD2                                       
REMARK 470     ASP B   2    CG   OD1  OD2                                       
REMARK 470     GLU B  14    CG   CD   OE1  OE2                                  
REMARK 470     PHE B  18    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASN B  19    CG   OD1  ND2                                       
REMARK 470     ARG B  25    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B  48    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU B  52    CG   CD   OE1  OE2                                  
REMARK 470     GLU B  69    CG   CD   OE1  OE2                                  
REMARK 470     ARG B  72    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B  94    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL B  95    CG1  CG2                                            
REMARK 470     GLU B  96    CG   CD   OE1  OE2                                  
REMARK 470     LYS B  98    CG   CD   CE   NZ                                   
REMARK 470     ARG B 105    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR B 106    OG1  CG2                                            
REMARK 470     ASN B 113    CG   OD1  ND2                                       
REMARK 470     LEU B 114    CG   CD1  CD2                                       
REMARK 470     LEU B 115    CG   CD1  CD2                                       
REMARK 470     GLU B 128    CG   CD   OE1  OE2                                  
REMARK 470     PHE B 132    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASN B 134    CG   OD1  ND2                                       
REMARK 470     VAL B 143    CG1  CG2                                            
REMARK 470     LEU B 158    CG   CD1  CD2                                       
REMARK 470     VAL B 159    CG1  CG2                                            
REMARK 470     MET B 160    CG   SD   CE                                        
REMARK 470     LEU B 161    CG   CD1  CD2                                       
REMARK 470     GLU B 162    CG   CD   OE1  OE2                                  
REMARK 470     PRO B 165    CG   CD                                             
REMARK 470     SER B 167    OG                                                  
REMARK 470     GLU B 169    CG   CD   OE1  OE2                                  
REMARK 470     GLN B 174    CG   CD   OE1  NE2                                  
REMARK 470     GLU B 176    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 187    CG   CD   OE1  OE2                                  
REMARK 470     ARG B 189    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP M   1    CG   OD1  OD2                                       
REMARK 470     THR M  11    OG1  CG2                                            
REMARK 470     LEU M  12    CG   CD1  CD2                                       
REMARK 470     SER M  13    OG                                                  
REMARK 470     THR M  19    OG1  CG2                                            
REMARK 470     LYS M  48    CG   CD   CE   NZ                                   
REMARK 470     LYS M  55    CG   CD   CE   NZ                                   
REMARK 470     LYS M  59    CG   CD   CE   NZ                                   
REMARK 470     LYS M  68    CG   CD   CE   NZ                                   
REMARK 470     SER M  79    OG                                                  
REMARK 470     SER M  83    OG                                                  
REMARK 470     SER M 108    OG                                                  
REMARK 470     LEU M 112    CG   CD1  CD2                                       
REMARK 470     LEU M 113    CG   CD1  CD2                                       
REMARK 470     ARG M 115    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO M 116    CG   CD                                             
REMARK 470     ASP M 117    CG   OD1  OD2                                       
REMARK 470     SER M 137    OG                                                  
REMARK 470     VAL M 138    CG1  CG2                                            
REMARK 470     CYS M 139    SG                                                  
REMARK 470     THR M 142    OG1  CG2                                            
REMARK 470     ASP M 145    CG   OD1  OD2                                       
REMARK 470     GLN M 147    CG   CD   OE1  NE2                                  
REMARK 470     ASP M 157    CG   OD1  OD2                                       
REMARK 470     TYR M 159    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE M 160    CG1  CG2  CD1                                       
REMARK 470     THR M 161    OG1  CG2                                            
REMARK 470     ASP M 162    CG   OD1  OD2                                       
REMARK 470     LYS M 163    CG   CD   CE   NZ                                   
REMARK 470     LEU M 166    CG   CD1  CD2                                       
REMARK 470     MET M 171    CG   SD   CE                                        
REMARK 470     ASN M 183    CG   OD1  ND2                                       
REMARK 470     PHE M 187    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     CYS M 189    SG                                                  
REMARK 470     PHE M 193    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASN M 194    CG   OD1  ND2                                       
REMARK 470     ILE M 197    CG1  CG2  CD1                                       
REMARK 470     ASP M 201    CG   OD1  OD2                                       
REMARK 470     LEU P  11    CG   CD1  CD2                                       
REMARK 470     ILE P  12    CG1  CG2  CD1                                       
REMARK 470     GLN P  41    CG   CD   OE1  NE2                                  
REMARK 470     ASN P  51    OD1  ND2                                            
REMARK 470     LYS P  57    CG   CD   CE   NZ                                   
REMARK 470     VAL P 117    CG1  CG2                                            
REMARK 470     GLU P 118    CG   CD   OE1  OE2                                  
REMARK 470     LEU P 120    CG   CD1  CD2                                       
REMARK 470     ASN P 122    CG   OD1  ND2                                       
REMARK 470     GLU P 132    CG   CD   OE1  OE2                                  
REMARK 470     GLU P 135    CG   CD   OE1  OE2                                  
REMARK 470     TYR P 154    OH                                                  
REMARK 470     GLU P 159    CG   CD   OE1  OE2                                  
REMARK 470     LYS P 167    CG   CD   CE   NZ                                   
REMARK 470     GLU P 168    CG   CD   OE1  OE2                                  
REMARK 470     VAL P 169    CG1  CG2                                            
REMARK 470     GLN P 178    CG   CD   OE1  NE2                                  
REMARK 470     LYS P 181    CG   CD   CE   NZ                                   
REMARK 470     LEU P 186    CG   CD1  CD2                                       
REMARK 470     ASP P 188    CG   OD1  OD2                                       
REMARK 470     LEU P 193    CD1  CD2                                            
REMARK 470     ARG P 198    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE P 203    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG P 208    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS P 210    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLN P 214    CG   CD   OE1  NE2                                  
REMARK 470     LYS P 232    CG   CD   CE   NZ                                   
REMARK 470     LYS D  39    CG   CD   CE   NZ                                   
REMARK 470     GLU D  40    CG   CD   OE1  OE2                                  
REMARK 470     GLU D  46    CG   CD   OE1  OE2                                  
REMARK 470     GLU D  47    CG   CD   OE1  OE2                                  
REMARK 470     LYS D  67    CG   CD   CE   NZ                                   
REMARK 470     GLU D  98    CG   CD   OE1  OE2                                  
REMARK 470     LEU D  99    CG   CD1  CD2                                       
REMARK 470     ARG D 100    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU D 101    CG   CD   OE1  OE2                                  
REMARK 470     LEU D 105    CG   CD1  CD2                                       
REMARK 470     PHE D 108    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP D 110    OD1  OD2                                            
REMARK 470     LYS D 111    CG   CD   CE   NZ                                   
REMARK 470     ASN D 118    CG   OD1  ND2                                       
REMARK 470     ARG D 123    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS D 126    CG   CD   CE   NZ                                   
REMARK 470     THR D 135    OG1  CG2                                            
REMARK 470     GLU D 141    CG   CD   OE1  OE2                                  
REMARK 470     LEU D 151    CG   CD1  CD2                                       
REMARK 470     THR D 157    OG1  CG2                                            
REMARK 470     GLU D 158    CG   CD   OE1  OE2                                  
REMARK 470     VAL D 160    CG1  CG2                                            
REMARK 470     ARG D 164    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU D 172    CG   CD   OE1  OE2                                  
REMARK 470     GLU D 179    CG   CD   OE1  OE2                                  
REMARK 470     ASP D 181    CG   OD1  OD2                                       
REMARK 470     GLU E  14    CG   CD   OE1  OE2                                  
REMARK 470     PHE E  18    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASN E  19    CG   OD1  ND2                                       
REMARK 470     ARG E  25    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG E  48    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU E  52    CG   CD   OE1  OE2                                  
REMARK 470     GLU E  69    CG   CD   OE1  OE2                                  
REMARK 470     ARG E  72    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG E  94    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL E  95    CG1  CG2                                            
REMARK 470     GLU E  96    CG   CD   OE1  OE2                                  
REMARK 470     LYS E  98    CG   CD   CE   NZ                                   
REMARK 470     ARG E 105    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN E 113    CG   OD1  ND2                                       
REMARK 470     LEU E 114    CG   CD1  CD2                                       
REMARK 470     LEU E 115    CG   CD1  CD2                                       
REMARK 470     ASN E 120    CG   OD1  ND2                                       
REMARK 470     GLU E 128    CG   CD   OE1  OE2                                  
REMARK 470     PHE E 132    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG E 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN E 134    CG   OD1  ND2                                       
REMARK 470     GLN E 136    CG   CD   OE1  NE2                                  
REMARK 470     GLU E 137    CG   CD   OE1  OE2                                  
REMARK 470     LEU E 158    CG   CD1  CD2                                       
REMARK 470     VAL E 159    CG1  CG2                                            
REMARK 470     MET E 160    CG   SD   CE                                        
REMARK 470     LEU E 161    CG   CD1  CD2                                       
REMARK 470     GLU E 162    CG   CD   OE1  OE2                                  
REMARK 470     PRO E 165    CG   CD                                             
REMARK 470     ARG E 166    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER E 167    OG                                                  
REMARK 470     GLU E 169    CG   CD   OE1  OE2                                  
REMARK 470     TYR E 171    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN E 174    CG   CD   OE1  NE2                                  
REMARK 470     GLU E 176    CG   CD   OE1  OE2                                  
REMARK 470     GLU E 187    CG   CD   OE1  OE2                                  
REMARK 470     ARG E 189    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR Q  11    OG1  CG2                                            
REMARK 470     LEU Q  12    CG   CD1  CD2                                       
REMARK 470     SER Q  13    OG                                                  
REMARK 470     LEU Q  18    CG   CD1  CD2                                       
REMARK 470     THR Q  19    OG1  CG2                                            
REMARK 470     ILE Q  20    CG1  CG2  CD1                                       
REMARK 470     LYS Q  48    CG   CD   CE   NZ                                   
REMARK 470     ASP Q  54    CG   OD1  OD2                                       
REMARK 470     LYS Q  55    CG   CD   CE   NZ                                   
REMARK 470     LYS Q  59    CG   CD   CE   NZ                                   
REMARK 470     LYS Q  68    CG   CD   CE   NZ                                   
REMARK 470     SER Q  79    OG                                                  
REMARK 470     SER Q  83    OG                                                  
REMARK 470     SER Q 108    OG                                                  
REMARK 470     LEU Q 113    CG   CD1  CD2                                       
REMARK 470     PRO Q 116    CG   CD                                             
REMARK 470     TYR Q 126    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LEU Q 128    CG   CD1  CD2                                       
REMARK 470     ARG Q 129    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP Q 130    CG   OD1  OD2                                       
REMARK 470     SER Q 131    OG                                                  
REMARK 470     SER Q 137    OG                                                  
REMARK 470     VAL Q 138    CG1  CG2                                            
REMARK 470     THR Q 142    OG1  CG2                                            
REMARK 470     ASP Q 145    CG   OD1  OD2                                       
REMARK 470     VAL Q 150    CG1  CG2                                            
REMARK 470     GLN Q 152    CG   CD   OE1  NE2                                  
REMARK 470     SER Q 153    OG                                                  
REMARK 470     ASP Q 157    CG   OD1  OD2                                       
REMARK 470     TYR Q 159    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE Q 160    CG1  CG2  CD1                                       
REMARK 470     ASP Q 162    CG   OD1  OD2                                       
REMARK 470     LYS Q 163    CG   CD   CE   NZ                                   
REMARK 470     LEU Q 166    CG   CD1  CD2                                       
REMARK 470     LYS Q 174    CG   CD   CE   NZ                                   
REMARK 470     ASN Q 176    CG   OD1  ND2                                       
REMARK 470     ASN Q 183    CG   OD1  ND2                                       
REMARK 470     LYS Q 184    CG   CD   CE   NZ                                   
REMARK 470     ILE Q 197    CG1  CG2  CD1                                       
REMARK 470     LEU R  11    CG   CD1  CD2                                       
REMARK 470     LYS R  13    CG   CD   CE   NZ                                   
REMARK 470     GLN R  41    CG   CD   OE1  NE2                                  
REMARK 470     ASN R  51    OD1  ND2                                            
REMARK 470     LYS R  57    CG   CD   CE   NZ                                   
REMARK 470     VAL R 117    CG1  CG2                                            
REMARK 470     GLU R 118    CG   CD   OE1  OE2                                  
REMARK 470     GLU R 135    CG   CD   OE1  OE2                                  
REMARK 470     GLU R 137    CG   CD   OE1  OE2                                  
REMARK 470     GLN R 142    CG   CD   OE1  NE2                                  
REMARK 470     LYS R 143    CG   CD   CE   NZ                                   
REMARK 470     TYR R 154    OH                                                  
REMARK 470     GLU R 159    CG   CD   OE1  OE2                                  
REMARK 470     LYS R 167    CG   CD   CE   NZ                                   
REMARK 470     GLU R 168    CG   CD   OE1  OE2                                  
REMARK 470     VAL R 169    CG1  CG2                                            
REMARK 470     GLN R 178    CG   CD   OE1  NE2                                  
REMARK 470     LYS R 181    CG   CD   CE   NZ                                   
REMARK 470     LEU R 186    CG   CD1  CD2                                       
REMARK 470     LEU R 193    CD1  CD2                                            
REMARK 470     ARG R 198    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE R 203    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     HIS R 210    CG   ND1  CD2  CE1  NE2                             
REMARK 470     PHE R 211    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU R 225    CG   CD   OE1  OE2                                  
REMARK 470     GLU G   4    CG   CD   OE1  OE2                                  
REMARK 470     LYS G  39    CG   CD   CE   NZ                                   
REMARK 470     GLU G  40    CG   CD   OE1  OE2                                  
REMARK 470     GLU G  46    CG   CD   OE1  OE2                                  
REMARK 470     GLU G  47    CG   CD   OE1  OE2                                  
REMARK 470     LYS G  67    CG   CD   CE   NZ                                   
REMARK 470     GLU G  98    CG   CD   OE1  OE2                                  
REMARK 470     LEU G  99    CG   CD1  CD2                                       
REMARK 470     ARG G 100    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU G 101    CG   CD   OE1  OE2                                  
REMARK 470     LEU G 105    CG   CD1  CD2                                       
REMARK 470     PHE G 108    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP G 110    OD1  OD2                                            
REMARK 470     LYS G 111    CG   CD   CE   NZ                                   
REMARK 470     ASN G 118    CG   OD1  ND2                                       
REMARK 470     ARG G 123    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS G 126    CG   CD   CE   NZ                                   
REMARK 470     THR G 135    OG1  CG2                                            
REMARK 470     GLU G 141    CG   CD   OE1  OE2                                  
REMARK 470     LEU G 151    CG   CD1  CD2                                       
REMARK 470     THR G 157    OG1  CG2                                            
REMARK 470     GLU G 158    CG   CD   OE1  OE2                                  
REMARK 470     VAL G 160    CG1  CG2                                            
REMARK 470     ARG G 164    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU G 172    CG   CD   OE1  OE2                                  
REMARK 470     GLU G 179    CG   CD   OE1  OE2                                  
REMARK 470     ASP G 181    CG   OD1  OD2                                       
REMARK 470     ASN H  19    CG   OD1  ND2                                       
REMARK 470     ARG H  48    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU H  52    CG   CD   OE1  OE2                                  
REMARK 470     GLU H  69    CG   CD   OE1  OE2                                  
REMARK 470     ARG H  72    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG H  94    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL H  95    CG1  CG2                                            
REMARK 470     GLU H  96    CG   CD   OE1  OE2                                  
REMARK 470     LYS H  98    CG   CD   CE   NZ                                   
REMARK 470     ASN H 113    CG   OD1  ND2                                       
REMARK 470     LEU H 114    CG   CD1  CD2                                       
REMARK 470     LEU H 115    CG   CD1  CD2                                       
REMARK 470     ASN H 120    CG   OD1  ND2                                       
REMARK 470     GLU H 128    CG   CD   OE1  OE2                                  
REMARK 470     PHE H 132    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU H 158    CG   CD1  CD2                                       
REMARK 470     VAL H 159    CG1  CG2                                            
REMARK 470     MET H 160    CG   SD   CE                                        
REMARK 470     LEU H 161    CG   CD1  CD2                                       
REMARK 470     GLU H 162    CG   CD   OE1  OE2                                  
REMARK 470     SER H 167    OG                                                  
REMARK 470     GLU H 169    CG   CD   OE1  OE2                                  
REMARK 470     TYR H 171    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN H 174    CG   CD   OE1  NE2                                  
REMARK 470     GLU H 176    CG   CD   OE1  OE2                                  
REMARK 470     GLU H 187    CG   CD   OE1  OE2                                  
REMARK 470     ARG H 189    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU S   7    CG   CD   OE1  OE2                                  
REMARK 470     VAL S  10    CG1  CG2                                            
REMARK 470     LEU S  12    CG   CD1  CD2                                       
REMARK 470     SER S  13    OG                                                  
REMARK 470     THR S  19    OG1  CG2                                            
REMARK 470     ASP S  54    CG   OD1  OD2                                       
REMARK 470     LYS S  55    CG   CD   CE   NZ                                   
REMARK 470     LYS S  59    CG   CD   CE   NZ                                   
REMARK 470     LYS S  68    CG   CD   CE   NZ                                   
REMARK 470     SER S  79    OG                                                  
REMARK 470     SER S  83    OG                                                  
REMARK 470     SER S 108    OG                                                  
REMARK 470     LEU S 113    CG   CD1  CD2                                       
REMARK 470     ARG S 115    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO S 116    CG   CD                                             
REMARK 470     ASN S 120    CG   OD1  ND2                                       
REMARK 470     ASP S 122    CG   OD1  OD2                                       
REMARK 470     VAL S 125    CG1  CG2                                            
REMARK 470     TYR S 126    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LEU S 140    CG   CD1  CD2                                       
REMARK 470     PHE S 141    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     THR S 142    OG1  CG2                                            
REMARK 470     PHE S 144    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP S 145    CG   OD1  OD2                                       
REMARK 470     GLN S 147    CG   CD   OE1  NE2                                  
REMARK 470     LYS S 154    CG   CD   CE   NZ                                   
REMARK 470     ASP S 155    CG   OD1  OD2                                       
REMARK 470     ASP S 157    CG   OD1  OD2                                       
REMARK 470     ILE S 160    CG1  CG2  CD1                                       
REMARK 470     ASP S 162    CG   OD1  OD2                                       
REMARK 470     LYS S 163    CG   CD   CE   NZ                                   
REMARK 470     LEU S 166    CG   CD1  CD2                                       
REMARK 470     ARG S 169    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     MET S 171    CG   SD   CE                                        
REMARK 470     ASP S 172    CG   OD1  OD2                                       
REMARK 470     LYS S 174    CG   CD   CE   NZ                                   
REMARK 470     ASN S 176    CG   OD1  ND2                                       
REMARK 470     ASN S 183    CG   OD1  ND2                                       
REMARK 470     ASP S 186    CG   OD1  OD2                                       
REMARK 470     PHE S 187    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PRO S 199    CG   CD                                             
REMARK 470     PHE S 203    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU T  11    CG   CD1  CD2                                       
REMARK 470     LYS T  13    CG   CD   CE   NZ                                   
REMARK 470     GLN T  41    CG   CD   OE1  NE2                                  
REMARK 470     ASN T  51    OD1  ND2                                            
REMARK 470     LYS T  57    CG   CD   CE   NZ                                   
REMARK 470     ASN T 122    CG   OD1  ND2                                       
REMARK 470     GLU T 127    CG   CD   OE1  OE2                                  
REMARK 470     ILE T 138    CG1  CG2  CD1                                       
REMARK 470     SER T 139    OG                                                  
REMARK 470     GLN T 142    CG   CD   OE1  NE2                                  
REMARK 470     LEU T 146    CG   CD1  CD2                                       
REMARK 470     TYR T 154    OH                                                  
REMARK 470     GLU T 159    CG   CD   OE1  OE2                                  
REMARK 470     LEU T 160    CG   CD1  CD2                                       
REMARK 470     SER T 161    OG                                                  
REMARK 470     VAL T 164    CG1  CG2                                            
REMARK 470     ASN T 165    CG   OD1  ND2                                       
REMARK 470     VAL T 169    CG1  CG2                                            
REMARK 470     HIS T 170    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL T 173    CG1  CG2                                            
REMARK 470     GLN T 178    CG   CD   OE1  NE2                                  
REMARK 470     LYS T 181    CG   CD   CE   NZ                                   
REMARK 470     LEU T 186    CG   CD1  CD2                                       
REMARK 470     ASP T 188    CG   OD1  OD2                                       
REMARK 470     LEU T 193    CD1  CD2                                            
REMARK 470     THR T 202    OG1  CG2                                            
REMARK 470     GLN T 205    CG   CD   OE1  NE2                                  
REMARK 470     ARG T 208    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS T 210    CG   ND1  CD2  CE1  NE2                             
REMARK 470     PHE T 211    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG T 212    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN T 214    CG   CD   OE1  NE2                                  
REMARK 470     LEU T 220    CG   CD1  CD2                                       
REMARK 470     GLU T 225    CG   CD   OE1  OE2                                  
REMARK 470     GLN T 228    CG   CD   OE1  NE2                                  
REMARK 470     LYS T 232    CG   CD   CE   NZ                                   
REMARK 470     TRP T 243    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP T 243    CZ3  CH2                                            
REMARK 470     ASP T 247    CG   OD1  OD2                                       
REMARK 470     LYS J  39    CG   CD   CE   NZ                                   
REMARK 470     GLU J  40    CG   CD   OE1  OE2                                  
REMARK 470     GLU J  46    CG   CD   OE1  OE2                                  
REMARK 470     GLU J  47    CG   CD   OE1  OE2                                  
REMARK 470     LYS J  67    CG   CD   CE   NZ                                   
REMARK 470     GLU J  98    CG   CD   OE1  OE2                                  
REMARK 470     LEU J  99    CG   CD1  CD2                                       
REMARK 470     ARG J 100    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU J 101    CG   CD   OE1  OE2                                  
REMARK 470     LEU J 105    CG   CD1  CD2                                       
REMARK 470     PHE J 108    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP J 110    OD1  OD2                                            
REMARK 470     LYS J 111    CG   CD   CE   NZ                                   
REMARK 470     ASN J 118    CG   OD1  ND2                                       
REMARK 470     ARG J 123    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS J 126    CG   CD   CE   NZ                                   
REMARK 470     THR J 135    OG1  CG2                                            
REMARK 470     GLU J 141    CG   CD   OE1  OE2                                  
REMARK 470     LEU J 151    CG   CD1  CD2                                       
REMARK 470     THR J 157    OG1  CG2                                            
REMARK 470     GLU J 158    CG   CD   OE1  OE2                                  
REMARK 470     VAL J 160    CG1  CG2                                            
REMARK 470     ARG J 164    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU J 172    CG   CD   OE1  OE2                                  
REMARK 470     GLU J 179    CG   CD   OE1  OE2                                  
REMARK 470     ASP J 181    CG   OD1  OD2                                       
REMARK 470     GLU K  14    CG   CD   OE1  OE2                                  
REMARK 470     ASN K  19    CG   OD1  ND2                                       
REMARK 470     ARG K  25    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG K  48    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU K  52    CG   CD   OE1  OE2                                  
REMARK 470     GLU K  69    CG   CD   OE1  OE2                                  
REMARK 470     ARG K  72    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG K  94    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL K  95    CG1  CG2                                            
REMARK 470     GLU K  96    CG   CD   OE1  OE2                                  
REMARK 470     LYS K  98    CG   CD   CE   NZ                                   
REMARK 470     ASN K 113    CG   OD1  ND2                                       
REMARK 470     LEU K 114    CG   CD1  CD2                                       
REMARK 470     LEU K 115    CG   CD1  CD2                                       
REMARK 470     ASN K 120    CG   OD1  ND2                                       
REMARK 470     GLU K 128    CG   CD   OE1  OE2                                  
REMARK 470     ARG K 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN K 134    CG   OD1  ND2                                       
REMARK 470     GLN K 136    CG   CD   OE1  NE2                                  
REMARK 470     GLU K 137    CG   CD   OE1  OE2                                  
REMARK 470     GLU K 138    CG   CD   OE1  OE2                                  
REMARK 470     LYS K 139    CG   CD   CE   NZ                                   
REMARK 470     LEU K 158    CG   CD1  CD2                                       
REMARK 470     VAL K 159    CG1  CG2                                            
REMARK 470     MET K 160    CG   SD   CE                                        
REMARK 470     LEU K 161    CG   CD1  CD2                                       
REMARK 470     GLU K 162    CG   CD   OE1  OE2                                  
REMARK 470     THR K 163    OG1  CG2                                            
REMARK 470     PRO K 165    CG   CD                                             
REMARK 470     ARG K 166    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR K 171    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN K 174    CG   CD   OE1  NE2                                  
REMARK 470     GLU K 176    CG   CD   OE1  OE2                                  
REMARK 470     GLU K 187    CG   CD   OE1  OE2                                  
REMARK 470     ARG K 189    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU U   7    CG   CD   OE1  OE2                                  
REMARK 470     THR U  11    OG1  CG2                                            
REMARK 470     SER U  13    OG                                                  
REMARK 470     THR U  19    OG1  CG2                                            
REMARK 470     ILE U  20    CG1  CG2  CD1                                       
REMARK 470     LYS U  48    CG   CD   CE   NZ                                   
REMARK 470     LYS U  51    CG   CD   CE   NZ                                   
REMARK 470     LYS U  59    CG   CD   CE   NZ                                   
REMARK 470     LYS U  68    CG   CD   CE   NZ                                   
REMARK 470     SER U  79    OG                                                  
REMARK 470     SER U  83    OG                                                  
REMARK 470     SER U 108    OG                                                  
REMARK 470     LEU U 112    CG   CD1  CD2                                       
REMARK 470     LEU U 113    CG   CD1  CD2                                       
REMARK 470     PRO U 116    CG   CD                                             
REMARK 470     GLN U 119    CG   CD   OE1  NE2                                  
REMARK 470     VAL U 125    CG1  CG2                                            
REMARK 470     GLN U 127    CG   CD   OE1  NE2                                  
REMARK 470     LEU U 128    CG   CD1  CD2                                       
REMARK 470     ARG U 129    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP U 130    CG   OD1  OD2                                       
REMARK 470     SER U 131    OG                                                  
REMARK 470     LYS U 132    CG   CD   CE   NZ                                   
REMARK 470     LYS U 136    CG   CD   CE   NZ                                   
REMARK 470     SER U 137    OG                                                  
REMARK 470     THR U 142    OG1  CG2                                            
REMARK 470     ASP U 145    CG   OD1  OD2                                       
REMARK 470     GLN U 147    CG   CD   OE1  NE2                                  
REMARK 470     ASN U 149    CG   OD1  ND2                                       
REMARK 470     SER U 151    OG                                                  
REMARK 470     GLN U 152    CG   CD   OE1  NE2                                  
REMARK 470     SER U 153    OG                                                  
REMARK 470     ASP U 157    CG   OD1  OD2                                       
REMARK 470     TYR U 159    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE U 160    CG1  CG2  CD1                                       
REMARK 470     LYS U 163    CG   CD   CE   NZ                                   
REMARK 470     LEU U 166    CG   CD1  CD2                                       
REMARK 470     MET U 171    CG   SD   CE                                        
REMARK 470     LYS U 174    CG   CD   CE   NZ                                   
REMARK 470     ASN U 176    CG   OD1  ND2                                       
REMARK 470     ASN U 183    CG   OD1  ND2                                       
REMARK 470     LYS U 184    CG   CD   CE   NZ                                   
REMARK 470     ASP U 186    CG   OD1  OD2                                       
REMARK 470     PHE U 187    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ILE U 197    CG1  CG2  CD1                                       
REMARK 470     ILE U 198    CG1  CG2  CD1                                       
REMARK 470     GLU U 200    CG   CD   OE1  OE2                                  
REMARK 470     THR U 202    OG1  CG2                                            
REMARK 470     PHE U 203    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE U 204    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PRO U 205    CG   CD                                             
REMARK 470     GLN V  41    CG   CD   OE1  NE2                                  
REMARK 470     ASN V  51    OD1  ND2                                            
REMARK 470     LYS V  57    CG   CD   CE   NZ                                   
REMARK 470     VAL V 117    CG1  CG2                                            
REMARK 470     LEU V 120    CG   CD1  CD2                                       
REMARK 470     GLU V 135    CG   CD   OE1  OE2                                  
REMARK 470     LYS V 143    CG   CD   CE   NZ                                   
REMARK 470     TYR V 154    OH                                                  
REMARK 470     LYS V 167    CG   CD   CE   NZ                                   
REMARK 470     VAL V 169    CG1  CG2                                            
REMARK 470     GLN V 178    CG   CD   OE1  NE2                                  
REMARK 470     LYS V 181    CG   CD   CE   NZ                                   
REMARK 470     LEU V 186    CG   CD1  CD2                                       
REMARK 470     ASP V 188    CG   OD1  OD2                                       
REMARK 470     LEU V 193    CD1  CD2                                            
REMARK 470     ARG V 198    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG V 208    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS V 210    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLN V 214    CG   CD   OE1  NE2                                  
REMARK 470     LEU V 220    CD1  CD2                                            
REMARK 470     GLU V 225    CG   CD   OE1  OE2                                  
REMARK 475                                                                      
REMARK 475 ZERO OCCUPANCY RESIDUES                                              
REMARK 475 THE FOLLOWING RESIDUES WERE MODELED WITH ZERO OCCUPANCY.             
REMARK 475 THE LOCATION AND PROPERTIES OF THESE RESIDUES MAY NOT                
REMARK 475 BE RELIABLE. (M=MODEL NUMBER; RES=RESIDUE NAME;                      
REMARK 475 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE)          
REMARK 475   M RES C  SSEQI                                                     
REMARK 475     ASN K   113                                                      
REMARK 480                                                                      
REMARK 480 ZERO OCCUPANCY ATOM                                                  
REMARK 480 THE FOLLOWING RESIDUES HAVE ATOMS MODELED WITH ZERO                  
REMARK 480 OCCUPANCY. THE LOCATION AND PROPERTIES OF THESE ATOMS                
REMARK 480 MAY NOT BE RELIABLE. (M=MODEL NUMBER; RES=RESIDUE NAME;              
REMARK 480 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):         
REMARK 480   M RES C SSEQI ATOMS                                                
REMARK 480     ARG B  166   NE   CZ   NH1  NH2                                  
REMARK 480     TYR B  171   CE1  CE2  CZ   OH                                   
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    LEU V    11     O    LEU V   114              1.97            
REMARK 500   O    PHE U    17     O    LYS U    77              2.03            
REMARK 500   OG   SER R    31     OE2  GLU R    48              2.04            
REMARK 500   O    LYS M    55     N    SER M    57              2.14            
REMARK 500   O    LEU R    46     O    LYS R    57              2.16            
REMARK 500   O    LEU P    11     O    LEU P   114              2.17            
REMARK 500   O    GLN B    64     N    ASP B    66              2.17            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    SER P  33   CB    SER P  33   OG      0.105                       
REMARK 500    SER R  33   CB    SER R  33   OG      0.112                       
REMARK 500    SER T  33   CB    SER T  33   OG      0.113                       
REMARK 500    SER V  33   CB    SER V  33   OG      0.115                       
REMARK 500    GLU V 132   CD    GLU V 132   OE1     0.280                       
REMARK 500    GLU V 132   CD    GLU V 132   OE2     1.277                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    THR B 163   N   -  CA  -  C   ANGL. DEV. =  17.7 DEGREES          
REMARK 500    PRO B 165   N   -  CA  -  CB  ANGL. DEV. =   8.0 DEGREES          
REMARK 500    GLN P  41   N   -  CA  -  C   ANGL. DEV. = -20.9 DEGREES          
REMARK 500    PRO D  81   C   -  N   -  CA  ANGL. DEV. =   9.1 DEGREES          
REMARK 500    PRO D 155   C   -  N   -  CA  ANGL. DEV. =  10.2 DEGREES          
REMARK 500    THR D 157   N   -  CA  -  C   ANGL. DEV. = -18.1 DEGREES          
REMARK 500    THR Q 161   N   -  CA  -  C   ANGL. DEV. =  16.9 DEGREES          
REMARK 500    VAL R 100   N   -  CA  -  C   ANGL. DEV. = -16.7 DEGREES          
REMARK 500    PRO R 184   C   -  N   -  CA  ANGL. DEV. =   9.8 DEGREES          
REMARK 500    PRO G 155   C   -  N   -  CA  ANGL. DEV. =   9.7 DEGREES          
REMARK 500    PRO T 184   C   -  N   -  CA  ANGL. DEV. =  11.5 DEGREES          
REMARK 500    PRO J 155   C   -  N   -  CA  ANGL. DEV. =   9.5 DEGREES          
REMARK 500    PRO V  25   C   -  N   -  CA  ANGL. DEV. =   9.9 DEGREES          
REMARK 500    VAL V 100   N   -  CA  -  C   ANGL. DEV. = -17.9 DEGREES          
REMARK 500    GLU V 132   OE1 -  CD  -  OE2 ANGL. DEV. = -90.2 DEGREES          
REMARK 500    GLU V 132   CG  -  CD  -  OE2 ANGL. DEV. = -26.8 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    HIS A   5      114.84   -169.76                                   
REMARK 500    ASP A  27       69.99     31.89                                   
REMARK 500    ALA A  37      -71.22    -81.35                                   
REMARK 500    GLU A  46      -14.50    -46.55                                   
REMARK 500    ALA A  56      -56.37     72.55                                   
REMARK 500    ASN A  78       30.31     87.37                                   
REMARK 500    LEU A  99      133.75    -34.64                                   
REMARK 500    GLU A 101       94.87   -171.10                                   
REMARK 500    PRO A 102      139.72    -19.87                                   
REMARK 500    ASN A 124       81.28     53.27                                   
REMARK 500    THR A 129       12.09   -142.93                                   
REMARK 500    VAL A 136     -159.60    -65.73                                   
REMARK 500    PRO A 139      170.58    -57.79                                   
REMARK 500    HIS A 143        4.21     83.36                                   
REMARK 500    LEU A 144     -156.91    -81.55                                   
REMARK 500    PRO A 155      127.77    -32.98                                   
REMARK 500    SER A 156     -173.69     27.11                                   
REMARK 500    THR A 157      -41.34    154.84                                   
REMARK 500    GLU A 158       17.66    161.48                                   
REMARK 500    TRP A 168      -18.28    -41.88                                   
REMARK 500    PHE A 180       74.62   -112.97                                   
REMARK 500    ASP B   2       80.36    -38.80                                   
REMARK 500    THR B   3      136.86     72.67                                   
REMARK 500    ARG B   4      -85.30    -81.77                                   
REMARK 500    GLU B  22      -72.89    -69.05                                   
REMARK 500    ASN B  33      -77.50     73.30                                   
REMARK 500    GLN B  34       -8.11   -144.28                                   
REMARK 500    SER B  42      -37.52    -30.74                                   
REMARK 500    ASP B  43       28.25    -77.78                                   
REMARK 500    VAL B  44       -4.91   -151.81                                   
REMARK 500    LEU B  53        5.99    -69.97                                   
REMARK 500    ALA B  58      -73.50    -59.23                                   
REMARK 500    LYS B  65       19.24     26.55                                   
REMARK 500    ASP B  76      -64.55    -92.00                                   
REMARK 500    TYR B  78      -80.63   -109.08                                   
REMARK 500    CYS B  79      -73.67    -35.41                                   
REMARK 500    THR B  90      -79.87    -90.65                                   
REMARK 500    PHE B 155     -159.63    -98.00                                   
REMARK 500    GLN B 156      140.67    163.53                                   
REMARK 500    LEU B 161     -129.28    -98.01                                   
REMARK 500    GLU B 162     -161.71    175.71                                   
REMARK 500    THR B 163     -167.88      9.29                                   
REMARK 500    VAL B 164     -111.28     41.03                                   
REMARK 500    PRO B 165      -24.95    148.48                                   
REMARK 500    ARG B 166     -124.20    152.26                                   
REMARK 500    SER B 167      -67.89    111.37                                   
REMARK 500    GLU B 169      166.34    -35.96                                   
REMARK 500    HIS C   2      -47.21   -161.60                                   
REMARK 500    VAL C   8      -44.92   -133.46                                   
REMARK 500    THR C   9       96.49     52.21                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     615 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500    TYR P  49         0.08    SIDE CHAIN                              
REMARK 500    TYR T  49         0.07    SIDE CHAIN                              
REMARK 500    GLU V 132         0.23    SIDE CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 1U3H   RELATED DB: PDB                                   
REMARK 900 CRYSTAL STRUCTURE OF MOUSE TCR 172.10 COMPLEXED WITH MHC CLASS II I- 
REMARK 900 AU MOLECULE AT 2.4 A                                                 
REMARK 900 RELATED ID: 1FYT   RELATED DB: PDB                                   
REMARK 900 CRYSTAL STRUCTURE OF A COMPLEX OF A HUMAN ALPHA/BETA-T CELL          
REMARK 900 RECEPTOR, INFLUENZA HA ANTIGEN PEPTIDE, AND MHC CLASS II MOLECULE,   
REMARK 900 HLA-DR1                                                              
DBREF  1ZGL A    1   181  UNP    P01903   2DRA_HUMAN      26    206             
DBREF  1ZGL B    1   192  UNP    Q29787   Q29787_HUMAN     1    192             
DBREF  1ZGL C    1    13  UNP    Q6AI64   Q6AI64_HUMAN    45     57             
DBREF  1ZGL M  116   211  UNP    P01848   TCA_HUMAN        1     96             
DBREF  1ZGL P  118   248  UNP    P01850   TCB_HUMAN        1    131             
DBREF  1ZGL D    1   181  UNP    P01903   2DRA_HUMAN      26    206             
DBREF  1ZGL E    1   192  UNP    Q29787   Q29787_HUMAN     1    192             
DBREF  1ZGL F    1    13  UNP    Q6AI64   Q6AI64_HUMAN    45     57             
DBREF  1ZGL Q  116   211  UNP    P01848   TCA_HUMAN        1     96             
DBREF  1ZGL R  118   248  UNP    P01850   TCB_HUMAN        1    131             
DBREF  1ZGL G    1   181  UNP    P01903   2DRA_HUMAN      26    206             
DBREF  1ZGL H    1   192  UNP    Q29787   Q29787_HUMAN     1    192             
DBREF  1ZGL I    1    13  UNP    Q6AI64   Q6AI64_HUMAN    45     57             
DBREF  1ZGL S  116   211  UNP    P01848   TCA_HUMAN        1     96             
DBREF  1ZGL T  118   248  UNP    P01850   TCB_HUMAN        1    131             
DBREF  1ZGL J    1   181  UNP    P01903   2DRA_HUMAN      26    206             
DBREF  1ZGL K    1   192  UNP    Q29787   Q29787_HUMAN     1    192             
DBREF  1ZGL L    1    13  UNP    Q6AI64   Q6AI64_HUMAN    45     57             
DBREF  1ZGL U  116   211  UNP    P01848   TCA_HUMAN        1     96             
DBREF  1ZGL V  118   248  UNP    P01850   TCB_HUMAN        1    131             
SEQADV 1ZGL GLY C   14  UNP  Q6AI64              CLONING ARTIFACT               
SEQADV 1ZGL GLY C   15  UNP  Q6AI64              CLONING ARTIFACT               
SEQADV 1ZGL GLY F   14  UNP  Q6AI64              CLONING ARTIFACT               
SEQADV 1ZGL GLY F   15  UNP  Q6AI64              CLONING ARTIFACT               
SEQADV 1ZGL GLY I   14  UNP  Q6AI64              CLONING ARTIFACT               
SEQADV 1ZGL GLY I   15  UNP  Q6AI64              CLONING ARTIFACT               
SEQADV 1ZGL GLY L   14  UNP  Q6AI64              CLONING ARTIFACT               
SEQADV 1ZGL GLY L   15  UNP  Q6AI64              CLONING ARTIFACT               
SEQRES   1 A  181  ILE LYS GLU GLU HIS VAL ILE ILE GLN ALA GLU PHE TYR          
SEQRES   2 A  181  LEU ASN PRO ASP GLN SER GLY GLU PHE MET PHE ASP PHE          
SEQRES   3 A  181  ASP GLY ASP GLU ILE PHE HIS VAL ASP MET ALA LYS LYS          
SEQRES   4 A  181  GLU THR VAL TRP ARG LEU GLU GLU PHE GLY ARG PHE ALA          
SEQRES   5 A  181  SER PHE GLU ALA GLN GLY ALA LEU ALA ASN ILE ALA VAL          
SEQRES   6 A  181  ASP LYS ALA ASN LEU GLU ILE MET THR LYS ARG SER ASN          
SEQRES   7 A  181  TYR THR PRO ILE THR ASN VAL PRO PRO GLU VAL THR VAL          
SEQRES   8 A  181  LEU THR ASN SER PRO VAL GLU LEU ARG GLU PRO ASN VAL          
SEQRES   9 A  181  LEU ILE CYS PHE ILE ASP LYS PHE THR PRO PRO VAL VAL          
SEQRES  10 A  181  ASN VAL THR TRP LEU ARG ASN GLY LYS PRO VAL THR THR          
SEQRES  11 A  181  GLY VAL SER GLU THR VAL PHE LEU PRO ARG GLU ASP HIS          
SEQRES  12 A  181  LEU PHE ARG LYS PHE HIS TYR LEU PRO PHE LEU PRO SER          
SEQRES  13 A  181  THR GLU ASP VAL TYR ASP CYS ARG VAL GLU HIS TRP GLY          
SEQRES  14 A  181  LEU ASP GLU PRO LEU LEU LYS HIS TRP GLU PHE ASP              
SEQRES   1 B  192  GLY ASP THR ARG PRO ARG PHE LEU GLN GLN ASP LYS TYR          
SEQRES   2 B  192  GLU CYS HIS PHE PHE ASN GLY THR GLU ARG VAL ARG PHE          
SEQRES   3 B  192  LEU HIS ARG ASP ILE TYR ASN GLN GLU GLU ASP LEU ARG          
SEQRES   4 B  192  PHE ASP SER ASP VAL GLY GLU TYR ARG ALA VAL THR GLU          
SEQRES   5 B  192  LEU GLY ARG PRO ASP ALA GLU TYR TRP ASN SER GLN LYS          
SEQRES   6 B  192  ASP PHE LEU GLU ASP ARG ARG ALA ALA VAL ASP THR TYR          
SEQRES   7 B  192  CYS ARG HIS ASN TYR GLY VAL GLY GLU SER PHE THR VAL          
SEQRES   8 B  192  GLN ARG ARG VAL GLU PRO LYS VAL THR VAL TYR PRO ALA          
SEQRES   9 B  192  ARG THR GLN THR LEU GLN HIS HIS ASN LEU LEU VAL CYS          
SEQRES  10 B  192  SER VAL ASN GLY PHE TYR PRO GLY SER ILE GLU VAL ARG          
SEQRES  11 B  192  TRP PHE ARG ASN SER GLN GLU GLU LYS ALA GLY VAL VAL          
SEQRES  12 B  192  SER THR GLY LEU ILE GLN ASN GLY ASP TRP THR PHE GLN          
SEQRES  13 B  192  THR LEU VAL MET LEU GLU THR VAL PRO ARG SER GLY GLU          
SEQRES  14 B  192  VAL TYR THR CYS GLN VAL GLU HIS PRO SER VAL THR SER          
SEQRES  15 B  192  PRO LEU THR VAL GLU TRP ARG ALA GLN SER                      
SEQRES   1 C   15  VAL HIS PHE PHE LYS ASN ILE VAL THR PRO ARG THR PRO          
SEQRES   2 C   15  GLY GLY                                                      
SEQRES   1 M  209  GLY ASP SER VAL THR GLN MET GLU GLY PRO VAL THR LEU          
SEQRES   2 M  209  SER GLU GLU ALA PHE LEU THR ILE ASN CYS THR TYR THR          
SEQRES   3 M  209  ALA THR GLY TYR PRO SER LEU PHE TRP TYR VAL GLN TYR          
SEQRES   4 M  209  PRO GLY GLU GLY LEU GLN LEU LEU LEU LYS ALA THR LYS          
SEQRES   5 M  209  ALA ASP ASP LYS GLY SER ASN LYS GLY PHE GLU ALA THR          
SEQRES   6 M  209  TYR ARG LYS GLU THR THR SER PHE HIS LEU GLU LYS GLY          
SEQRES   7 M  209  SER VAL GLN VAL SER ASP SER ALA VAL TYR PHE CYS ALA          
SEQRES   8 M  209  LEU SER GLY GLY ASP SER SER TYR LYS LEU ILE PHE GLY          
SEQRES   9 M  209  SER GLY THR ARG LEU LEU VAL ARG PRO ASP ILE GLN ASN          
SEQRES  10 M  209  PRO ASP PRO ALA VAL TYR GLN LEU ARG ASP SER LYS SER          
SEQRES  11 M  209  SER ASP LYS SER VAL CYS LEU PHE THR ASP PHE ASP SER          
SEQRES  12 M  209  GLN THR ASN VAL SER GLN SER LYS ASP SER ASP VAL TYR          
SEQRES  13 M  209  ILE THR ASP LYS THR VAL LEU ASP MET ARG SER MET ASP          
SEQRES  14 M  209  PHE LYS SER ASN SER ALA VAL ALA TRP SER ASN LYS SER          
SEQRES  15 M  209  ASP PHE ALA CYS ALA ASN ALA PHE ASN ASN SER ILE ILE          
SEQRES  16 M  209  PRO GLU ASP THR PHE PHE PRO SER PRO GLU SER SER CYS          
SEQRES  17 M  209  ALA                                                          
SEQRES   1 P  249  GLY GLY GLY GLY GLY VAL THR GLN THR PRO ARG TYR LEU          
SEQRES   2 P  249  ILE LYS THR ARG GLY GLN GLN VAL THR LEU SER CYS SER          
SEQRES   3 P  249  PRO ILE SER GLY HIS ARG SER VAL SER TRP TYR GLN GLN          
SEQRES   4 P  249  THR PRO GLY GLN GLY LEU GLN PHE LEU PHE GLU TYR PHE          
SEQRES   5 P  249  ASN GLU THR GLN ARG ASN LYS GLY ASN PHE PRO GLY ARG          
SEQRES   6 P  249  PHE SER GLY ARG GLN PHE SER ASN SER ARG SER GLU MET          
SEQRES   7 P  249  ASN VAL SER THR LEU GLU LEU GLY ASP SER ALA LEU TYR          
SEQRES   8 P  249  LEU CYS ALA SER SER LEU ALA ASP ARG VAL ASN THR GLU          
SEQRES   9 P  249  ALA PHE PHE GLY GLN GLY THR ARG LEU THR VAL VAL GLU          
SEQRES  10 P  249  ASP LEU LYS ASN VAL PHE PRO PRO GLU VAL ALA VAL PHE          
SEQRES  11 P  249  GLU PRO SER GLU ALA GLU ILE SER HIS THR GLN LYS ALA          
SEQRES  12 P  249  THR LEU VAL CYS LEU ALA THR GLY PHE TYR PRO ASP HIS          
SEQRES  13 P  249  VAL GLU LEU SER TRP TRP VAL ASN GLY LYS GLU VAL HIS          
SEQRES  14 P  249  SER GLY VAL SER THR ASP PRO GLN PRO LEU LYS GLU GLN          
SEQRES  15 P  249  PRO ALA LEU ASN ASP SER ARG TYR SER LEU SER SER ARG          
SEQRES  16 P  249  LEU ARG VAL SER ALA THR PHE TRP GLN ASN PRO ARG ASN          
SEQRES  17 P  249  HIS PHE ARG CYS GLN VAL GLN PHE TYR GLY LEU SER GLU          
SEQRES  18 P  249  ASN ASP GLU TRP THR GLN ASP ARG ALA LYS PRO VAL THR          
SEQRES  19 P  249  GLN ILE VAL SER ALA GLU ALA TRP GLY ARG ALA ASP CYS          
SEQRES  20 P  249  ALA ALA                                                      
SEQRES   1 D  181  ILE LYS GLU GLU HIS VAL ILE ILE GLN ALA GLU PHE TYR          
SEQRES   2 D  181  LEU ASN PRO ASP GLN SER GLY GLU PHE MET PHE ASP PHE          
SEQRES   3 D  181  ASP GLY ASP GLU ILE PHE HIS VAL ASP MET ALA LYS LYS          
SEQRES   4 D  181  GLU THR VAL TRP ARG LEU GLU GLU PHE GLY ARG PHE ALA          
SEQRES   5 D  181  SER PHE GLU ALA GLN GLY ALA LEU ALA ASN ILE ALA VAL          
SEQRES   6 D  181  ASP LYS ALA ASN LEU GLU ILE MET THR LYS ARG SER ASN          
SEQRES   7 D  181  TYR THR PRO ILE THR ASN VAL PRO PRO GLU VAL THR VAL          
SEQRES   8 D  181  LEU THR ASN SER PRO VAL GLU LEU ARG GLU PRO ASN VAL          
SEQRES   9 D  181  LEU ILE CYS PHE ILE ASP LYS PHE THR PRO PRO VAL VAL          
SEQRES  10 D  181  ASN VAL THR TRP LEU ARG ASN GLY LYS PRO VAL THR THR          
SEQRES  11 D  181  GLY VAL SER GLU THR VAL PHE LEU PRO ARG GLU ASP HIS          
SEQRES  12 D  181  LEU PHE ARG LYS PHE HIS TYR LEU PRO PHE LEU PRO SER          
SEQRES  13 D  181  THR GLU ASP VAL TYR ASP CYS ARG VAL GLU HIS TRP GLY          
SEQRES  14 D  181  LEU ASP GLU PRO LEU LEU LYS HIS TRP GLU PHE ASP              
SEQRES   1 E  192  GLY ASP THR ARG PRO ARG PHE LEU GLN GLN ASP LYS TYR          
SEQRES   2 E  192  GLU CYS HIS PHE PHE ASN GLY THR GLU ARG VAL ARG PHE          
SEQRES   3 E  192  LEU HIS ARG ASP ILE TYR ASN GLN GLU GLU ASP LEU ARG          
SEQRES   4 E  192  PHE ASP SER ASP VAL GLY GLU TYR ARG ALA VAL THR GLU          
SEQRES   5 E  192  LEU GLY ARG PRO ASP ALA GLU TYR TRP ASN SER GLN LYS          
SEQRES   6 E  192  ASP PHE LEU GLU ASP ARG ARG ALA ALA VAL ASP THR TYR          
SEQRES   7 E  192  CYS ARG HIS ASN TYR GLY VAL GLY GLU SER PHE THR VAL          
SEQRES   8 E  192  GLN ARG ARG VAL GLU PRO LYS VAL THR VAL TYR PRO ALA          
SEQRES   9 E  192  ARG THR GLN THR LEU GLN HIS HIS ASN LEU LEU VAL CYS          
SEQRES  10 E  192  SER VAL ASN GLY PHE TYR PRO GLY SER ILE GLU VAL ARG          
SEQRES  11 E  192  TRP PHE ARG ASN SER GLN GLU GLU LYS ALA GLY VAL VAL          
SEQRES  12 E  192  SER THR GLY LEU ILE GLN ASN GLY ASP TRP THR PHE GLN          
SEQRES  13 E  192  THR LEU VAL MET LEU GLU THR VAL PRO ARG SER GLY GLU          
SEQRES  14 E  192  VAL TYR THR CYS GLN VAL GLU HIS PRO SER VAL THR SER          
SEQRES  15 E  192  PRO LEU THR VAL GLU TRP ARG ALA GLN SER                      
SEQRES   1 F   15  VAL HIS PHE PHE LYS ASN ILE VAL THR PRO ARG THR PRO          
SEQRES   2 F   15  GLY GLY                                                      
SEQRES   1 Q  209  GLY ASP SER VAL THR GLN MET GLU GLY PRO VAL THR LEU          
SEQRES   2 Q  209  SER GLU GLU ALA PHE LEU THR ILE ASN CYS THR TYR THR          
SEQRES   3 Q  209  ALA THR GLY TYR PRO SER LEU PHE TRP TYR VAL GLN TYR          
SEQRES   4 Q  209  PRO GLY GLU GLY LEU GLN LEU LEU LEU LYS ALA THR LYS          
SEQRES   5 Q  209  ALA ASP ASP LYS GLY SER ASN LYS GLY PHE GLU ALA THR          
SEQRES   6 Q  209  TYR ARG LYS GLU THR THR SER PHE HIS LEU GLU LYS GLY          
SEQRES   7 Q  209  SER VAL GLN VAL SER ASP SER ALA VAL TYR PHE CYS ALA          
SEQRES   8 Q  209  LEU SER GLY GLY ASP SER SER TYR LYS LEU ILE PHE GLY          
SEQRES   9 Q  209  SER GLY THR ARG LEU LEU VAL ARG PRO ASP ILE GLN ASN          
SEQRES  10 Q  209  PRO ASP PRO ALA VAL TYR GLN LEU ARG ASP SER LYS SER          
SEQRES  11 Q  209  SER ASP LYS SER VAL CYS LEU PHE THR ASP PHE ASP SER          
SEQRES  12 Q  209  GLN THR ASN VAL SER GLN SER LYS ASP SER ASP VAL TYR          
SEQRES  13 Q  209  ILE THR ASP LYS THR VAL LEU ASP MET ARG SER MET ASP          
SEQRES  14 Q  209  PHE LYS SER ASN SER ALA VAL ALA TRP SER ASN LYS SER          
SEQRES  15 Q  209  ASP PHE ALA CYS ALA ASN ALA PHE ASN ASN SER ILE ILE          
SEQRES  16 Q  209  PRO GLU ASP THR PHE PHE PRO SER PRO GLU SER SER CYS          
SEQRES  17 Q  209  ALA                                                          
SEQRES   1 R  249  GLY GLY GLY GLY GLY VAL THR GLN THR PRO ARG TYR LEU          
SEQRES   2 R  249  ILE LYS THR ARG GLY GLN GLN VAL THR LEU SER CYS SER          
SEQRES   3 R  249  PRO ILE SER GLY HIS ARG SER VAL SER TRP TYR GLN GLN          
SEQRES   4 R  249  THR PRO GLY GLN GLY LEU GLN PHE LEU PHE GLU TYR PHE          
SEQRES   5 R  249  ASN GLU THR GLN ARG ASN LYS GLY ASN PHE PRO GLY ARG          
SEQRES   6 R  249  PHE SER GLY ARG GLN PHE SER ASN SER ARG SER GLU MET          
SEQRES   7 R  249  ASN VAL SER THR LEU GLU LEU GLY ASP SER ALA LEU TYR          
SEQRES   8 R  249  LEU CYS ALA SER SER LEU ALA ASP ARG VAL ASN THR GLU          
SEQRES   9 R  249  ALA PHE PHE GLY GLN GLY THR ARG LEU THR VAL VAL GLU          
SEQRES  10 R  249  ASP LEU LYS ASN VAL PHE PRO PRO GLU VAL ALA VAL PHE          
SEQRES  11 R  249  GLU PRO SER GLU ALA GLU ILE SER HIS THR GLN LYS ALA          
SEQRES  12 R  249  THR LEU VAL CYS LEU ALA THR GLY PHE TYR PRO ASP HIS          
SEQRES  13 R  249  VAL GLU LEU SER TRP TRP VAL ASN GLY LYS GLU VAL HIS          
SEQRES  14 R  249  SER GLY VAL SER THR ASP PRO GLN PRO LEU LYS GLU GLN          
SEQRES  15 R  249  PRO ALA LEU ASN ASP SER ARG TYR SER LEU SER SER ARG          
SEQRES  16 R  249  LEU ARG VAL SER ALA THR PHE TRP GLN ASN PRO ARG ASN          
SEQRES  17 R  249  HIS PHE ARG CYS GLN VAL GLN PHE TYR GLY LEU SER GLU          
SEQRES  18 R  249  ASN ASP GLU TRP THR GLN ASP ARG ALA LYS PRO VAL THR          
SEQRES  19 R  249  GLN ILE VAL SER ALA GLU ALA TRP GLY ARG ALA ASP CYS          
SEQRES  20 R  249  ALA ALA                                                      
SEQRES   1 G  181  ILE LYS GLU GLU HIS VAL ILE ILE GLN ALA GLU PHE TYR          
SEQRES   2 G  181  LEU ASN PRO ASP GLN SER GLY GLU PHE MET PHE ASP PHE          
SEQRES   3 G  181  ASP GLY ASP GLU ILE PHE HIS VAL ASP MET ALA LYS LYS          
SEQRES   4 G  181  GLU THR VAL TRP ARG LEU GLU GLU PHE GLY ARG PHE ALA          
SEQRES   5 G  181  SER PHE GLU ALA GLN GLY ALA LEU ALA ASN ILE ALA VAL          
SEQRES   6 G  181  ASP LYS ALA ASN LEU GLU ILE MET THR LYS ARG SER ASN          
SEQRES   7 G  181  TYR THR PRO ILE THR ASN VAL PRO PRO GLU VAL THR VAL          
SEQRES   8 G  181  LEU THR ASN SER PRO VAL GLU LEU ARG GLU PRO ASN VAL          
SEQRES   9 G  181  LEU ILE CYS PHE ILE ASP LYS PHE THR PRO PRO VAL VAL          
SEQRES  10 G  181  ASN VAL THR TRP LEU ARG ASN GLY LYS PRO VAL THR THR          
SEQRES  11 G  181  GLY VAL SER GLU THR VAL PHE LEU PRO ARG GLU ASP HIS          
SEQRES  12 G  181  LEU PHE ARG LYS PHE HIS TYR LEU PRO PHE LEU PRO SER          
SEQRES  13 G  181  THR GLU ASP VAL TYR ASP CYS ARG VAL GLU HIS TRP GLY          
SEQRES  14 G  181  LEU ASP GLU PRO LEU LEU LYS HIS TRP GLU PHE ASP              
SEQRES   1 H  192  GLY ASP THR ARG PRO ARG PHE LEU GLN GLN ASP LYS TYR          
SEQRES   2 H  192  GLU CYS HIS PHE PHE ASN GLY THR GLU ARG VAL ARG PHE          
SEQRES   3 H  192  LEU HIS ARG ASP ILE TYR ASN GLN GLU GLU ASP LEU ARG          
SEQRES   4 H  192  PHE ASP SER ASP VAL GLY GLU TYR ARG ALA VAL THR GLU          
SEQRES   5 H  192  LEU GLY ARG PRO ASP ALA GLU TYR TRP ASN SER GLN LYS          
SEQRES   6 H  192  ASP PHE LEU GLU ASP ARG ARG ALA ALA VAL ASP THR TYR          
SEQRES   7 H  192  CYS ARG HIS ASN TYR GLY VAL GLY GLU SER PHE THR VAL          
SEQRES   8 H  192  GLN ARG ARG VAL GLU PRO LYS VAL THR VAL TYR PRO ALA          
SEQRES   9 H  192  ARG THR GLN THR LEU GLN HIS HIS ASN LEU LEU VAL CYS          
SEQRES  10 H  192  SER VAL ASN GLY PHE TYR PRO GLY SER ILE GLU VAL ARG          
SEQRES  11 H  192  TRP PHE ARG ASN SER GLN GLU GLU LYS ALA GLY VAL VAL          
SEQRES  12 H  192  SER THR GLY LEU ILE GLN ASN GLY ASP TRP THR PHE GLN          
SEQRES  13 H  192  THR LEU VAL MET LEU GLU THR VAL PRO ARG SER GLY GLU          
SEQRES  14 H  192  VAL TYR THR CYS GLN VAL GLU HIS PRO SER VAL THR SER          
SEQRES  15 H  192  PRO LEU THR VAL GLU TRP ARG ALA GLN SER                      
SEQRES   1 I   15  VAL HIS PHE PHE LYS ASN ILE VAL THR PRO ARG THR PRO          
SEQRES   2 I   15  GLY GLY                                                      
SEQRES   1 S  209  GLY ASP SER VAL THR GLN MET GLU GLY PRO VAL THR LEU          
SEQRES   2 S  209  SER GLU GLU ALA PHE LEU THR ILE ASN CYS THR TYR THR          
SEQRES   3 S  209  ALA THR GLY TYR PRO SER LEU PHE TRP TYR VAL GLN TYR          
SEQRES   4 S  209  PRO GLY GLU GLY LEU GLN LEU LEU LEU LYS ALA THR LYS          
SEQRES   5 S  209  ALA ASP ASP LYS GLY SER ASN LYS GLY PHE GLU ALA THR          
SEQRES   6 S  209  TYR ARG LYS GLU THR THR SER PHE HIS LEU GLU LYS GLY          
SEQRES   7 S  209  SER VAL GLN VAL SER ASP SER ALA VAL TYR PHE CYS ALA          
SEQRES   8 S  209  LEU SER GLY GLY ASP SER SER TYR LYS LEU ILE PHE GLY          
SEQRES   9 S  209  SER GLY THR ARG LEU LEU VAL ARG PRO ASP ILE GLN ASN          
SEQRES  10 S  209  PRO ASP PRO ALA VAL TYR GLN LEU ARG ASP SER LYS SER          
SEQRES  11 S  209  SER ASP LYS SER VAL CYS LEU PHE THR ASP PHE ASP SER          
SEQRES  12 S  209  GLN THR ASN VAL SER GLN SER LYS ASP SER ASP VAL TYR          
SEQRES  13 S  209  ILE THR ASP LYS THR VAL LEU ASP MET ARG SER MET ASP          
SEQRES  14 S  209  PHE LYS SER ASN SER ALA VAL ALA TRP SER ASN LYS SER          
SEQRES  15 S  209  ASP PHE ALA CYS ALA ASN ALA PHE ASN ASN SER ILE ILE          
SEQRES  16 S  209  PRO GLU ASP THR PHE PHE PRO SER PRO GLU SER SER CYS          
SEQRES  17 S  209  ALA                                                          
SEQRES   1 T  249  GLY GLY GLY GLY GLY VAL THR GLN THR PRO ARG TYR LEU          
SEQRES   2 T  249  ILE LYS THR ARG GLY GLN GLN VAL THR LEU SER CYS SER          
SEQRES   3 T  249  PRO ILE SER GLY HIS ARG SER VAL SER TRP TYR GLN GLN          
SEQRES   4 T  249  THR PRO GLY GLN GLY LEU GLN PHE LEU PHE GLU TYR PHE          
SEQRES   5 T  249  ASN GLU THR GLN ARG ASN LYS GLY ASN PHE PRO GLY ARG          
SEQRES   6 T  249  PHE SER GLY ARG GLN PHE SER ASN SER ARG SER GLU MET          
SEQRES   7 T  249  ASN VAL SER THR LEU GLU LEU GLY ASP SER ALA LEU TYR          
SEQRES   8 T  249  LEU CYS ALA SER SER LEU ALA ASP ARG VAL ASN THR GLU          
SEQRES   9 T  249  ALA PHE PHE GLY GLN GLY THR ARG LEU THR VAL VAL GLU          
SEQRES  10 T  249  ASP LEU LYS ASN VAL PHE PRO PRO GLU VAL ALA VAL PHE          
SEQRES  11 T  249  GLU PRO SER GLU ALA GLU ILE SER HIS THR GLN LYS ALA          
SEQRES  12 T  249  THR LEU VAL CYS LEU ALA THR GLY PHE TYR PRO ASP HIS          
SEQRES  13 T  249  VAL GLU LEU SER TRP TRP VAL ASN GLY LYS GLU VAL HIS          
SEQRES  14 T  249  SER GLY VAL SER THR ASP PRO GLN PRO LEU LYS GLU GLN          
SEQRES  15 T  249  PRO ALA LEU ASN ASP SER ARG TYR SER LEU SER SER ARG          
SEQRES  16 T  249  LEU ARG VAL SER ALA THR PHE TRP GLN ASN PRO ARG ASN          
SEQRES  17 T  249  HIS PHE ARG CYS GLN VAL GLN PHE TYR GLY LEU SER GLU          
SEQRES  18 T  249  ASN ASP GLU TRP THR GLN ASP ARG ALA LYS PRO VAL THR          
SEQRES  19 T  249  GLN ILE VAL SER ALA GLU ALA TRP GLY ARG ALA ASP CYS          
SEQRES  20 T  249  ALA ALA                                                      
SEQRES   1 J  181  ILE LYS GLU GLU HIS VAL ILE ILE GLN ALA GLU PHE TYR          
SEQRES   2 J  181  LEU ASN PRO ASP GLN SER GLY GLU PHE MET PHE ASP PHE          
SEQRES   3 J  181  ASP GLY ASP GLU ILE PHE HIS VAL ASP MET ALA LYS LYS          
SEQRES   4 J  181  GLU THR VAL TRP ARG LEU GLU GLU PHE GLY ARG PHE ALA          
SEQRES   5 J  181  SER PHE GLU ALA GLN GLY ALA LEU ALA ASN ILE ALA VAL          
SEQRES   6 J  181  ASP LYS ALA ASN LEU GLU ILE MET THR LYS ARG SER ASN          
SEQRES   7 J  181  TYR THR PRO ILE THR ASN VAL PRO PRO GLU VAL THR VAL          
SEQRES   8 J  181  LEU THR ASN SER PRO VAL GLU LEU ARG GLU PRO ASN VAL          
SEQRES   9 J  181  LEU ILE CYS PHE ILE ASP LYS PHE THR PRO PRO VAL VAL          
SEQRES  10 J  181  ASN VAL THR TRP LEU ARG ASN GLY LYS PRO VAL THR THR          
SEQRES  11 J  181  GLY VAL SER GLU THR VAL PHE LEU PRO ARG GLU ASP HIS          
SEQRES  12 J  181  LEU PHE ARG LYS PHE HIS TYR LEU PRO PHE LEU PRO SER          
SEQRES  13 J  181  THR GLU ASP VAL TYR ASP CYS ARG VAL GLU HIS TRP GLY          
SEQRES  14 J  181  LEU ASP GLU PRO LEU LEU LYS HIS TRP GLU PHE ASP              
SEQRES   1 K  192  GLY ASP THR ARG PRO ARG PHE LEU GLN GLN ASP LYS TYR          
SEQRES   2 K  192  GLU CYS HIS PHE PHE ASN GLY THR GLU ARG VAL ARG PHE          
SEQRES   3 K  192  LEU HIS ARG ASP ILE TYR ASN GLN GLU GLU ASP LEU ARG          
SEQRES   4 K  192  PHE ASP SER ASP VAL GLY GLU TYR ARG ALA VAL THR GLU          
SEQRES   5 K  192  LEU GLY ARG PRO ASP ALA GLU TYR TRP ASN SER GLN LYS          
SEQRES   6 K  192  ASP PHE LEU GLU ASP ARG ARG ALA ALA VAL ASP THR TYR          
SEQRES   7 K  192  CYS ARG HIS ASN TYR GLY VAL GLY GLU SER PHE THR VAL          
SEQRES   8 K  192  GLN ARG ARG VAL GLU PRO LYS VAL THR VAL TYR PRO ALA          
SEQRES   9 K  192  ARG THR GLN THR LEU GLN HIS HIS ASN LEU LEU VAL CYS          
SEQRES  10 K  192  SER VAL ASN GLY PHE TYR PRO GLY SER ILE GLU VAL ARG          
SEQRES  11 K  192  TRP PHE ARG ASN SER GLN GLU GLU LYS ALA GLY VAL VAL          
SEQRES  12 K  192  SER THR GLY LEU ILE GLN ASN GLY ASP TRP THR PHE GLN          
SEQRES  13 K  192  THR LEU VAL MET LEU GLU THR VAL PRO ARG SER GLY GLU          
SEQRES  14 K  192  VAL TYR THR CYS GLN VAL GLU HIS PRO SER VAL THR SER          
SEQRES  15 K  192  PRO LEU THR VAL GLU TRP ARG ALA GLN SER                      
SEQRES   1 L   15  VAL HIS PHE PHE LYS ASN ILE VAL THR PRO ARG THR PRO          
SEQRES   2 L   15  GLY GLY                                                      
SEQRES   1 U  209  GLY ASP SER VAL THR GLN MET GLU GLY PRO VAL THR LEU          
SEQRES   2 U  209  SER GLU GLU ALA PHE LEU THR ILE ASN CYS THR TYR THR          
SEQRES   3 U  209  ALA THR GLY TYR PRO SER LEU PHE TRP TYR VAL GLN TYR          
SEQRES   4 U  209  PRO GLY GLU GLY LEU GLN LEU LEU LEU LYS ALA THR LYS          
SEQRES   5 U  209  ALA ASP ASP LYS GLY SER ASN LYS GLY PHE GLU ALA THR          
SEQRES   6 U  209  TYR ARG LYS GLU THR THR SER PHE HIS LEU GLU LYS GLY          
SEQRES   7 U  209  SER VAL GLN VAL SER ASP SER ALA VAL TYR PHE CYS ALA          
SEQRES   8 U  209  LEU SER GLY GLY ASP SER SER TYR LYS LEU ILE PHE GLY          
SEQRES   9 U  209  SER GLY THR ARG LEU LEU VAL ARG PRO ASP ILE GLN ASN          
SEQRES  10 U  209  PRO ASP PRO ALA VAL TYR GLN LEU ARG ASP SER LYS SER          
SEQRES  11 U  209  SER ASP LYS SER VAL CYS LEU PHE THR ASP PHE ASP SER          
SEQRES  12 U  209  GLN THR ASN VAL SER GLN SER LYS ASP SER ASP VAL TYR          
SEQRES  13 U  209  ILE THR ASP LYS THR VAL LEU ASP MET ARG SER MET ASP          
SEQRES  14 U  209  PHE LYS SER ASN SER ALA VAL ALA TRP SER ASN LYS SER          
SEQRES  15 U  209  ASP PHE ALA CYS ALA ASN ALA PHE ASN ASN SER ILE ILE          
SEQRES  16 U  209  PRO GLU ASP THR PHE PHE PRO SER PRO GLU SER SER CYS          
SEQRES  17 U  209  ALA                                                          
SEQRES   1 V  249  GLY GLY GLY GLY GLY VAL THR GLN THR PRO ARG TYR LEU          
SEQRES   2 V  249  ILE LYS THR ARG GLY GLN GLN VAL THR LEU SER CYS SER          
SEQRES   3 V  249  PRO ILE SER GLY HIS ARG SER VAL SER TRP TYR GLN GLN          
SEQRES   4 V  249  THR PRO GLY GLN GLY LEU GLN PHE LEU PHE GLU TYR PHE          
SEQRES   5 V  249  ASN GLU THR GLN ARG ASN LYS GLY ASN PHE PRO GLY ARG          
SEQRES   6 V  249  PHE SER GLY ARG GLN PHE SER ASN SER ARG SER GLU MET          
SEQRES   7 V  249  ASN VAL SER THR LEU GLU LEU GLY ASP SER ALA LEU TYR          
SEQRES   8 V  249  LEU CYS ALA SER SER LEU ALA ASP ARG VAL ASN THR GLU          
SEQRES   9 V  249  ALA PHE PHE GLY GLN GLY THR ARG LEU THR VAL VAL GLU          
SEQRES  10 V  249  ASP LEU LYS ASN VAL PHE PRO PRO GLU VAL ALA VAL PHE          
SEQRES  11 V  249  GLU PRO SER GLU ALA GLU ILE SER HIS THR GLN LYS ALA          
SEQRES  12 V  249  THR LEU VAL CYS LEU ALA THR GLY PHE TYR PRO ASP HIS          
SEQRES  13 V  249  VAL GLU LEU SER TRP TRP VAL ASN GLY LYS GLU VAL HIS          
SEQRES  14 V  249  SER GLY VAL SER THR ASP PRO GLN PRO LEU LYS GLU GLN          
SEQRES  15 V  249  PRO ALA LEU ASN ASP SER ARG TYR SER LEU SER SER ARG          
SEQRES  16 V  249  LEU ARG VAL SER ALA THR PHE TRP GLN ASN PRO ARG ASN          
SEQRES  17 V  249  HIS PHE ARG CYS GLN VAL GLN PHE TYR GLY LEU SER GLU          
SEQRES  18 V  249  ASN ASP GLU TRP THR GLN ASP ARG ALA LYS PRO VAL THR          
SEQRES  19 V  249  GLN ILE VAL SER ALA GLU ALA TRP GLY ARG ALA ASP CYS          
SEQRES  20 V  249  ALA ALA                                                      
HELIX    1   1 GLU A   47  PHE A   51  5                                   5    
HELIX    2   2 GLY A   58  SER A   77  1                                  20    
HELIX    3   3 ASP B   43  GLY B   45  5                                   3    
HELIX    4   4 THR B   51  LEU B   53  5                                   3    
HELIX    5   5 GLY B   54  SER B   63  1                                  10    
HELIX    6   6 ASP B   66  ALA B   73  1                                   8    
HELIX    7   7 ALA B   73  TYR B   78  1                                   6    
HELIX    8   8 TYR B   78  SER B   88  1                                  11    
HELIX    9   9 GLN M   81  SER M   85  5                                   5    
HELIX   10  10 MET M  168  ASP M  172  5                                   5    
HELIX   11  11 GLU P  135  GLN P  142  1                                   8    
HELIX   12  12 SER P  200  GLN P  205  1                                   6    
HELIX   13  13 LEU D   45  PHE D   51  5                                   7    
HELIX   14  14 GLY D   58  ASN D   78  1                                  21    
HELIX   15  15 ASP E   43  GLY E   45  5                                   3    
HELIX   16  16 GLY E   54  ASN E   62  1                                   9    
HELIX   17  17 ASP E   66  ALA E   73  1                                   8    
HELIX   18  18 ALA E   73  TYR E   78  1                                   6    
HELIX   19  19 TYR E   78  SER E   88  1                                  11    
HELIX   20  20 ALA Q  188  PHE Q  193  1                                   6    
HELIX   21  21 ASP R  119  VAL R  123  5                                   5    
HELIX   22  22 GLU R  135  GLN R  142  1                                   8    
HELIX   23  23 ALA R  201  GLN R  205  1                                   5    
HELIX   24  24 LEU G   45  PHE G   51  5                                   7    
HELIX   25  25 GLY G   58  SER G   77  1                                  20    
HELIX   26  26 ASP H   43  GLY H   45  5                                   3    
HELIX   27  27 THR H   51  LEU H   53  5                                   3    
HELIX   28  28 GLY H   54  ASN H   62  1                                   9    
HELIX   29  29 LYS H   65  ALA H   73  1                                   9    
HELIX   30  30 ALA H   73  TYR H   78  1                                   6    
HELIX   31  31 TYR H   78  SER H   88  1                                  11    
HELIX   32  32 GLN S   81  SER S   85  5                                   5    
HELIX   33  33 GLU T   83  SER T   87  5                                   5    
HELIX   34  34 ASP T  119  VAL T  123  5                                   5    
HELIX   35  35 LEU J   45  PHE J   51  5                                   7    
HELIX   36  36 ALA J   56  ASN J   78  1                                  23    
HELIX   37  37 THR K   51  LEU K   53  5                                   3    
HELIX   38  38 GLY K   54  ASN K   62  1                                   9    
HELIX   39  39 ASP K   66  ALA K   73  1                                   8    
HELIX   40  40 ALA K   73  TYR K   78  1                                   6    
HELIX   41  41 TYR K   78  SER K   88  1                                  11    
HELIX   42  42 GLN U   81  SER U   85  5                                   5    
HELIX   43  43 MET U  168  ASP U  172  5                                   5    
HELIX   44  44 ASP V  119  VAL V  123  5                                   5    
HELIX   45  45 GLU V  135  THR V  141  1                                   7    
HELIX   46  46 ALA V  201  ASN V  206  1                                   6    
SHEET    1   A 8 GLU A  40  TRP A  43  0                                        
SHEET    2   A 8 ASP A  29  ASP A  35 -1  N  HIS A  33   O  VAL A  42           
SHEET    3   A 8 SER A  19  PHE A  26 -1  N  PHE A  26   O  ASP A  29           
SHEET    4   A 8 HIS A   5  ASN A  15 -1  N  ILE A   8   O  ASP A  25           
SHEET    5   A 8 PHE B   7  PHE B  18 -1  O  ASP B  11   N  GLU A  11           
SHEET    6   A 8 ARG B  23  TYR B  32 -1  O  ARG B  25   N  HIS B  16           
SHEET    7   A 8 GLU B  35  ASP B  41 -1  O  LEU B  38   N  ASP B  30           
SHEET    8   A 8 TYR B  47  ALA B  49 -1  O  ARG B  48   N  ARG B  39           
SHEET    1   B 2 SER A  53  PHE A  54  0                                        
SHEET    2   B 2 PHE C   3  PHE C   4  1  O  PHE C   4   N  SER A  53           
SHEET    1   C 4 GLU A  88  THR A  93  0                                        
SHEET    2   C 4 ASN A 103  PHE A 112 -1  O  ILE A 106   N  LEU A  92           
SHEET    3   C 4 PHE A 145  PHE A 153 -1  O  HIS A 149   N  CYS A 107           
SHEET    4   C 4 SER A 133  GLU A 134 -1  N  SER A 133   O  TYR A 150           
SHEET    1   D 4 PRO A 127  VAL A 128  0                                        
SHEET    2   D 4 ASN A 118  LEU A 122 -1  N  TRP A 121   O  VAL A 128           
SHEET    3   D 4 TYR A 161  GLU A 166 -1  O  ARG A 164   N  THR A 120           
SHEET    4   D 4 LEU A 174  TRP A 178 -1  O  LEU A 174   N  VAL A 165           
SHEET    1   E 4 THR B 100  TYR B 102  0                                        
SHEET    2   E 4 VAL B 116  ASN B 120 -1  O  VAL B 116   N  TYR B 102           
SHEET    3   E 4 PHE B 155  MET B 160 -1  O  VAL B 159   N  CYS B 117           
SHEET    4   E 4 ILE B 148  GLN B 149 -1  N  ILE B 148   O  GLN B 156           
SHEET    1   F 3 GLU B 128  ARG B 130  0                                        
SHEET    2   F 3 THR B 172  GLU B 176 -1  O  GLU B 176   N  GLU B 128           
SHEET    3   F 3 LEU B 184  GLU B 187 -1  O  LEU B 184   N  VAL B 175           
SHEET    1   G 2 VAL M   3  GLN M   5  0                                        
SHEET    2   G 2 CYS M  22  TYR M  24 -1  O  THR M  23   N  THR M   4           
SHEET    1   H 2 THR M  19  ILE M  20  0                                        
SHEET    2   H 2 LEU M  75  GLU M  76 -1  O  LEU M  75   N  ILE M  20           
SHEET    1   I 4 GLN M  44  LEU M  47  0                                        
SHEET    2   I 4 SER M  31  GLN M  37 -1  N  VAL M  36   O  GLN M  44           
SHEET    3   I 4 VAL M  87  SER M  93 -1  O  PHE M  89   N  TYR M  35           
SHEET    4   I 4 ILE M 105  PHE M 106 -1  O  ILE M 105   N  LEU M  92           
SHEET    1   J 4 GLN M  44  LEU M  47  0                                        
SHEET    2   J 4 SER M  31  GLN M  37 -1  N  VAL M  36   O  GLN M  44           
SHEET    3   J 4 VAL M  87  SER M  93 -1  O  PHE M  89   N  TYR M  35           
SHEET    4   J 4 THR M 110  ARG M 111 -1  O  THR M 110   N  TYR M  88           
SHEET    1   K 3 VAL M 138  THR M 142  0                                        
SHEET    2   K 3 ASN M 176  TRP M 181 -1  O  ALA M 180   N  CYS M 139           
SHEET    3   K 3 THR M 164  VAL M 165 -1  N  THR M 164   O  SER M 177           
SHEET    1   L 4 THR P   5  THR P   7  0                                        
SHEET    2   L 4 VAL P  19  SER P  24 -1  O  SER P  24   N  THR P   5           
SHEET    3   L 4 SER P  75  VAL P  79 -1  O  SER P  75   N  CYS P  23           
SHEET    4   L 4 PHE P  65  GLN P  69 -1  N  SER P  66   O  ASN P  78           
SHEET    1   M 4 GLN P  44  TYR P  49  0                                        
SHEET    2   M 4 SER P  31  GLN P  37 -1  N  GLN P  36   O  GLN P  44           
SHEET    3   M 4 LEU P  89  SER P  95 -1  O  LEU P  91   N  TYR P  35           
SHEET    4   M 4 PHE P 107  PHE P 108 -1  O  PHE P 107   N  SER P  94           
SHEET    1   N 4 GLN P  44  TYR P  49  0                                        
SHEET    2   N 4 SER P  31  GLN P  37 -1  N  GLN P  36   O  GLN P  44           
SHEET    3   N 4 LEU P  89  SER P  95 -1  O  LEU P  91   N  TYR P  35           
SHEET    4   N 4 THR P 112  ARG P 113 -1  O  THR P 112   N  TYR P  90           
SHEET    1   O 3 THR P 145  PHE P 153  0                                        
SHEET    2   O 3 TYR P 191  ARG P 198 -1  O  SER P 195   N  CYS P 148           
SHEET    3   O 3 VAL P 173  THR P 175 -1  N  SER P 174   O  ARG P 196           
SHEET    1   P 3 THR P 145  PHE P 153  0                                        
SHEET    2   P 3 TYR P 191  ARG P 198 -1  O  SER P 195   N  CYS P 148           
SHEET    3   P 3 LEU P 180  LYS P 181 -1  N  LEU P 180   O  SER P 192           
SHEET    1   Q 4 VAL P 158  GLU P 159  0                                        
SHEET    2   Q 4 PHE P 211  PHE P 217 -1  O  GLN P 216   N  GLU P 159           
SHEET    3   Q 4 TRP P 162  VAL P 164 -1  N  TRP P 163   O  ARG P 212           
SHEET    4   Q 4 LYS P 167  GLU P 168 -1  O  LYS P 167   N  VAL P 164           
SHEET    1   R 3 VAL P 158  GLU P 159  0                                        
SHEET    2   R 3 PHE P 211  PHE P 217 -1  O  GLN P 216   N  GLU P 159           
SHEET    3   R 3 ILE P 237  ALA P 240 -1  O  ALA P 240   N  CYS P 213           
SHEET    1   S 8 GLU D  40  TRP D  43  0                                        
SHEET    2   S 8 ASP D  29  ASP D  35 -1  N  HIS D  33   O  VAL D  42           
SHEET    3   S 8 SER D  19  PHE D  26 -1  N  PHE D  24   O  PHE D  32           
SHEET    4   S 8 HIS D   5  ASN D  15 -1  N  ILE D   8   O  ASP D  25           
SHEET    5   S 8 PHE E   7  PHE E  18 -1  O  PHE E  17   N  HIS D   5           
SHEET    6   S 8 ARG E  23  TYR E  32 -1  O  LEU E  27   N  GLU E  14           
SHEET    7   S 8 GLU E  35  ASP E  41 -1  O  LEU E  38   N  ASP E  30           
SHEET    8   S 8 TYR E  47  ARG E  48 -1  O  ARG E  48   N  ARG E  39           
SHEET    1   T 4 GLU D  88  THR D  93  0                                        
SHEET    2   T 4 ASN D 103  PHE D 112 -1  O  ILE D 106   N  LEU D  92           
SHEET    3   T 4 PHE D 145  PHE D 153 -1  O  LYS D 147   N  ILE D 109           
SHEET    4   T 4 SER D 133  PRO D 139 -1  N  SER D 133   O  TYR D 150           
SHEET    1   U 4 LYS D 126  PRO D 127  0                                        
SHEET    2   U 4 ASN D 118  ARG D 123 -1  N  ARG D 123   O  LYS D 126           
SHEET    3   U 4 TYR D 161  GLU D 166 -1  O  ARG D 164   N  THR D 120           
SHEET    4   U 4 LEU D 174  TRP D 178 -1  O  LEU D 174   N  VAL D 165           
SHEET    1   V 4 THR E 100  TYR E 102  0                                        
SHEET    2   V 4 LEU E 115  PHE E 122 -1  O  SER E 118   N  THR E 100           
SHEET    3   V 4 PHE E 155  LEU E 161 -1  O  PHE E 155   N  PHE E 122           
SHEET    4   V 4 ILE E 148  GLN E 149 -1  N  ILE E 148   O  GLN E 156           
SHEET    1   W 2 VAL E 129  ARG E 130  0                                        
SHEET    2   W 2 GLN E 174  VAL E 175 -1  O  GLN E 174   N  ARG E 130           
SHEET    1   X 2 TYR E 171  THR E 172  0                                        
SHEET    2   X 2 GLU E 187  TRP E 188 -1  O  TRP E 188   N  TYR E 171           
SHEET    1   Y 2 VAL Q   3  GLN Q   5  0                                        
SHEET    2   Y 2 CYS Q  22  TYR Q  24 -1  O  THR Q  23   N  THR Q   4           
SHEET    1   Z 2 LEU Q  12  SER Q  13  0                                        
SHEET    2   Z 2 VAL Q 114  ARG Q 115  1  O  ARG Q 115   N  LEU Q  12           
SHEET    1  AA 2 THR Q  19  ILE Q  20  0                                        
SHEET    2  AA 2 LEU Q  75  GLU Q  76 -1  O  LEU Q  75   N  ILE Q  20           
SHEET    1  AB 4 GLN Q  44  ALA Q  49  0                                        
SHEET    2  AB 4 SER Q  31  GLN Q  37 -1  N  LEU Q  32   O  ALA Q  49           
SHEET    3  AB 4 VAL Q  87  SER Q  93 -1  O  ALA Q  91   N  PHE Q  33           
SHEET    4  AB 4 ILE Q 105  PHE Q 106 -1  O  ILE Q 105   N  LEU Q  92           
SHEET    1  AC 4 GLN Q  44  ALA Q  49  0                                        
SHEET    2  AC 4 SER Q  31  GLN Q  37 -1  N  LEU Q  32   O  ALA Q  49           
SHEET    3  AC 4 VAL Q  87  SER Q  93 -1  O  ALA Q  91   N  PHE Q  33           
SHEET    4  AC 4 THR Q 110  ARG Q 111 -1  O  THR Q 110   N  TYR Q  88           
SHEET    1  AD 3 VAL Q 138  THR Q 142  0                                        
SHEET    2  AD 3 LYS Q 174  TRP Q 181 -1  O  ALA Q 180   N  CYS Q 139           
SHEET    3  AD 3 VAL Q 165  ASP Q 167 -1  N  LEU Q 166   O  SER Q 175           
SHEET    1  AE 4 THR R   5  THR R   7  0                                        
SHEET    2  AE 4 VAL R  19  SER R  24 -1  O  SER R  22   N  THR R   7           
SHEET    3  AE 4 SER R  75  VAL R  79 -1  O  MET R  77   N  LEU R  21           
SHEET    4  AE 4 PHE R  65  GLN R  69 -1  N  SER R  66   O  ASN R  78           
SHEET    1  AF 4 GLN R  44  PHE R  50  0                                        
SHEET    2  AF 4 SER R  31  GLN R  36 -1  N  TRP R  34   O  LEU R  46           
SHEET    3  AF 4 LEU R  89  SER R  95 -1  O  LEU R  91   N  TYR R  35           
SHEET    4  AF 4 PHE R 107  PHE R 108 -1  O  PHE R 107   N  SER R  94           
SHEET    1  AG 4 GLN R  44  PHE R  50  0                                        
SHEET    2  AG 4 SER R  31  GLN R  36 -1  N  TRP R  34   O  LEU R  46           
SHEET    3  AG 4 LEU R  89  SER R  95 -1  O  LEU R  91   N  TYR R  35           
SHEET    4  AG 4 THR R 112  ARG R 113 -1  O  THR R 112   N  TYR R  90           
SHEET    1  AH 4 VAL R 128  PHE R 131  0                                        
SHEET    2  AH 4 LYS R 143  PHE R 153 -1  O  VAL R 147   N  PHE R 131           
SHEET    3  AH 4 SER R 195  SER R 200 -1  O  LEU R 197   N  LEU R 146           
SHEET    4  AH 4 VAL R 173  THR R 175 -1  N  SER R 174   O  ARG R 196           
SHEET    1  AI 3 VAL R 128  PHE R 131  0                                        
SHEET    2  AI 3 LYS R 143  PHE R 153 -1  O  VAL R 147   N  PHE R 131           
SHEET    3  AI 3 TYR R 191  LEU R 193 -1  O  TYR R 191   N  PHE R 153           
SHEET    1  AJ 4 LYS R 167  GLU R 168  0                                        
SHEET    2  AJ 4 LEU R 160  VAL R 164 -1  N  VAL R 164   O  LYS R 167           
SHEET    3  AJ 4 PHE R 211  VAL R 215 -1  O  ARG R 212   N  TRP R 163           
SHEET    4  AJ 4 VAL R 238  ALA R 240 -1  O  VAL R 238   N  VAL R 215           
SHEET    1  AK 8 THR G  41  TRP G  43  0                                        
SHEET    2  AK 8 ASP G  29  VAL G  34 -1  N  HIS G  33   O  VAL G  42           
SHEET    3  AK 8 SER G  19  PHE G  26 -1  N  PHE G  26   O  ASP G  29           
SHEET    4  AK 8 HIS G   5  ASN G  15 -1  N  LEU G  14   O  SER G  19           
SHEET    5  AK 8 PHE H   7  PHE H  18 -1  O  PHE H  17   N  HIS G   5           
SHEET    6  AK 8 ARG H  23  TYR H  32 -1  O  LEU H  27   N  GLU H  14           
SHEET    7  AK 8 GLU H  35  ASP H  41 -1  O  LEU H  38   N  ASP H  30           
SHEET    8  AK 8 TYR H  47  ARG H  48 -1  O  ARG H  48   N  ARG H  39           
SHEET    1  AL 4 GLU G  88  THR G  93  0                                        
SHEET    2  AL 4 ASN G 103  PHE G 112 -1  O  ASP G 110   N  GLU G  88           
SHEET    3  AL 4 PHE G 145  PHE G 153 -1  O  LEU G 151   N  LEU G 105           
SHEET    4  AL 4 SER G 133  GLU G 134 -1  N  SER G 133   O  TYR G 150           
SHEET    1  AM 4 GLU G  88  THR G  93  0                                        
SHEET    2  AM 4 ASN G 103  PHE G 112 -1  O  ASP G 110   N  GLU G  88           
SHEET    3  AM 4 PHE G 145  PHE G 153 -1  O  LEU G 151   N  LEU G 105           
SHEET    4  AM 4 LEU G 138  PRO G 139 -1  N  LEU G 138   O  ARG G 146           
SHEET    1  AN 4 LYS G 126  VAL G 128  0                                        
SHEET    2  AN 4 ASN G 118  ARG G 123 -1  N  ARG G 123   O  LYS G 126           
SHEET    3  AN 4 TYR G 161  GLU G 166 -1  O  GLU G 166   N  ASN G 118           
SHEET    4  AN 4 HIS G 177  TRP G 178 -1  O  TRP G 178   N  TYR G 161           
SHEET    1  AO 4 VAL H  99  PRO H 103  0                                        
SHEET    2  AO 4 LEU H 115  PHE H 122 -1  O  VAL H 116   N  TYR H 102           
SHEET    3  AO 4 PHE H 155  LEU H 161 -1  O  PHE H 155   N  PHE H 122           
SHEET    4  AO 4 ILE H 148  GLN H 149 -1  N  ILE H 148   O  GLN H 156           
SHEET    1  AP 2 GLU H 128  PHE H 132  0                                        
SHEET    2  AP 2 THR H 172  GLU H 176 -1  O  GLU H 176   N  GLU H 128           
SHEET    1  AQ 2 SER S   2  GLN S   5  0                                        
SHEET    2  AQ 2 CYS S  22  THR S  25 -1  O  THR S  23   N  THR S   4           
SHEET    1  AR 2 LEU S  12  SER S  13  0                                        
SHEET    2  AR 2 VAL S 114  ARG S 115  1  O  ARG S 115   N  LEU S  12           
SHEET    1  AS 2 THR S  19  ILE S  20  0                                        
SHEET    2  AS 2 LEU S  75  GLU S  76 -1  O  LEU S  75   N  ILE S  20           
SHEET    1  AT 3 SER S  31  GLN S  37  0                                        
SHEET    2  AT 3 VAL S  87  SER S  93 -1  O  SER S  93   N  SER S  31           
SHEET    3  AT 3 ILE S 105  PHE S 106 -1  O  ILE S 105   N  LEU S  92           
SHEET    1  AU 3 SER S  31  GLN S  37  0                                        
SHEET    2  AU 3 VAL S  87  SER S  93 -1  O  SER S  93   N  SER S  31           
SHEET    3  AU 3 THR S 110  ARG S 111 -1  O  THR S 110   N  TYR S  88           
SHEET    1  AV 4 THR T   5  THR T   7  0                                        
SHEET    2  AV 4 GLN T  18  SER T  24 -1  O  SER T  22   N  THR T   7           
SHEET    3  AV 4 SER T  75  SER T  80 -1  O  MET T  77   N  LEU T  21           
SHEET    4  AV 4 PHE T  65  GLN T  69 -1  N  SER T  66   O  ASN T  78           
SHEET    1  AW 2 LYS T  13  THR T  14  0                                        
SHEET    2  AW 2 VAL T 116  VAL T 117  1  O  VAL T 117   N  LYS T  13           
SHEET    1  AX 4 GLN T  44  PHE T  50  0                                        
SHEET    2  AX 4 SER T  31  GLN T  37 -1  N  TRP T  34   O  LEU T  46           
SHEET    3  AX 4 LEU T  89  SER T  95 -1  O  LEU T  91   N  TYR T  35           
SHEET    4  AX 4 THR T 112  ARG T 113 -1  O  THR T 112   N  TYR T  90           
SHEET    1  AY 3 CYS T 148  LEU T 149  0                                        
SHEET    2  AY 3 SER T 194  ARG T 196 -1  O  SER T 195   N  CYS T 148           
SHEET    3  AY 3 SER T 174  THR T 175 -1  N  SER T 174   O  ARG T 196           
SHEET    1  AZ 2 VAL T 158  GLU T 159  0                                        
SHEET    2  AZ 2 GLN T 216  PHE T 217 -1  N  GLN T 216   O  GLU T 159           
SHEET    1  BA 2 TRP T 162  VAL T 164  0                                        
SHEET    2  BA 2 PHE T 211  CYS T 213 -1  O  ARG T 212   N  TRP T 163           
SHEET    1  BB 8 GLU J  40  TRP J  43  0                                        
SHEET    2  BB 8 ASP J  29  ASP J  35 -1  N  ASP J  35   O  GLU J  40           
SHEET    3  BB 8 GLY J  20  PHE J  26 -1  N  PHE J  26   O  ASP J  29           
SHEET    4  BB 8 HIS J   5  ASN J  15 -1  N  ALA J  10   O  MET J  23           
SHEET    5  BB 8 PHE K   7  PHE K  18 -1  O  PHE K   7   N  ASN J  15           
SHEET    6  BB 8 ARG K  23  TYR K  32 -1  O  LEU K  27   N  GLU K  14           
SHEET    7  BB 8 GLU K  35  ASP K  41 -1  O  GLU K  35   N  TYR K  32           
SHEET    8  BB 8 TYR K  47  ALA K  49 -1  O  ARG K  48   N  ARG K  39           
SHEET    1  BC 4 GLU J  88  THR J  93  0                                        
SHEET    2  BC 4 ASN J 103  PHE J 112 -1  O  ILE J 106   N  LEU J  92           
SHEET    3  BC 4 PHE J 145  PHE J 153 -1  O  HIS J 149   N  CYS J 107           
SHEET    4  BC 4 SER J 133  GLU J 134 -1  N  SER J 133   O  TYR J 150           
SHEET    1  BD 4 GLU J  88  THR J  93  0                                        
SHEET    2  BD 4 ASN J 103  PHE J 112 -1  O  ILE J 106   N  LEU J  92           
SHEET    3  BD 4 PHE J 145  PHE J 153 -1  O  HIS J 149   N  CYS J 107           
SHEET    4  BD 4 LEU J 138  PRO J 139 -1  N  LEU J 138   O  ARG J 146           
SHEET    1  BE 4 PRO J 127  VAL J 128  0                                        
SHEET    2  BE 4 ASN J 118  ARG J 123 -1  N  TRP J 121   O  VAL J 128           
SHEET    3  BE 4 TYR J 161  GLU J 166 -1  O  ARG J 164   N  THR J 120           
SHEET    4  BE 4 LEU J 174  TRP J 178 -1  O  LEU J 174   N  VAL J 165           
SHEET    1  BF 4 VAL K 101  TYR K 102  0                                        
SHEET    2  BF 4 LEU K 114  PHE K 122 -1  O  VAL K 116   N  TYR K 102           
SHEET    3  BF 4 PHE K 155  GLU K 162 -1  O  PHE K 155   N  PHE K 122           
SHEET    4  BF 4 ILE K 148  GLN K 149 -1  N  ILE K 148   O  GLN K 156           
SHEET    1  BG 3 GLU K 128  ARG K 133  0                                        
SHEET    2  BG 3 TYR K 171  GLU K 176 -1  O  THR K 172   N  PHE K 132           
SHEET    3  BG 3 LEU K 184  TRP K 188 -1  O  TRP K 188   N  TYR K 171           
SHEET    1  BH 2 VAL U   3  GLN U   5  0                                        
SHEET    2  BH 2 CYS U  22  TYR U  24 -1  O  THR U  23   N  THR U   4           
SHEET    1  BI 3 THR U  19  ILE U  20  0                                        
SHEET    2  BI 3 LEU U  75  LYS U  77 -1  O  LEU U  75   N  ILE U  20           
SHEET    3  BI 3 PHE U  62  GLU U  63 -1  N  GLU U  63   O  GLU U  76           
SHEET    1  BJ 4 GLN U  44  ALA U  49  0                                        
SHEET    2  BJ 4 SER U  31  VAL U  36 -1  N  LEU U  32   O  ALA U  49           
SHEET    3  BJ 4 VAL U  87  SER U  93 -1  O  PHE U  89   N  TYR U  35           
SHEET    4  BJ 4 ILE U 105  PHE U 106 -1  O  ILE U 105   N  LEU U  92           
SHEET    1  BK 4 GLN U  44  ALA U  49  0                                        
SHEET    2  BK 4 SER U  31  VAL U  36 -1  N  LEU U  32   O  ALA U  49           
SHEET    3  BK 4 VAL U  87  SER U  93 -1  O  PHE U  89   N  TYR U  35           
SHEET    4  BK 4 THR U 110  ARG U 111 -1  O  THR U 110   N  TYR U  88           
SHEET    1  BL 2 TYR U  66  ARG U  67  0                                        
SHEET    2  BL 2 SER U  72  PHE U  73 -1  O  SER U  72   N  ARG U  67           
SHEET    1  BM 3 CYS U 139  THR U 142  0                                        
SHEET    2  BM 3 SER U 175  ALA U 180 -1  O  ALA U 180   N  CYS U 139           
SHEET    3  BM 3 THR U 164  LEU U 166 -1  N  LEU U 166   O  SER U 175           
SHEET    1  BN 4 THR V   5  THR V   7  0                                        
SHEET    2  BN 4 VAL V  19  SER V  24 -1  O  SER V  22   N  THR V   7           
SHEET    3  BN 4 SER V  75  VAL V  79 -1  O  MET V  77   N  LEU V  21           
SHEET    4  BN 4 PHE V  65  GLN V  69 -1  N  SER V  66   O  ASN V  78           
SHEET    1  BO 4 GLN V  44  PHE V  50  0                                        
SHEET    2  BO 4 SER V  31  GLN V  37 -1  N  TRP V  34   O  LEU V  46           
SHEET    3  BO 4 LEU V  89  SER V  95 -1  O  LEU V  89   N  GLN V  37           
SHEET    4  BO 4 PHE V 107  PHE V 108 -1  O  PHE V 107   N  SER V  94           
SHEET    1  BP 4 GLN V  44  PHE V  50  0                                        
SHEET    2  BP 4 SER V  31  GLN V  37 -1  N  TRP V  34   O  LEU V  46           
SHEET    3  BP 4 LEU V  89  SER V  95 -1  O  LEU V  89   N  GLN V  37           
SHEET    4  BP 4 THR V 112  ARG V 113 -1  O  THR V 112   N  TYR V  90           
SHEET    1  BQ 4 GLU V 127  PHE V 131  0                                        
SHEET    2  BQ 4 LYS V 143  PHE V 153 -1  O  VAL V 147   N  PHE V 131           
SHEET    3  BQ 4 TYR V 191  SER V 200 -1  O  VAL V 199   N  ALA V 144           
SHEET    4  BQ 4 VAL V 173  THR V 175 -1  N  SER V 174   O  ARG V 196           
SHEET    1  BR 4 GLU V 127  PHE V 131  0                                        
SHEET    2  BR 4 LYS V 143  PHE V 153 -1  O  VAL V 147   N  PHE V 131           
SHEET    3  BR 4 TYR V 191  SER V 200 -1  O  VAL V 199   N  ALA V 144           
SHEET    4  BR 4 LEU V 180  LYS V 181 -1  N  LEU V 180   O  SER V 192           
SHEET    1  BS 4 GLU V 168  VAL V 169  0                                        
SHEET    2  BS 4 VAL V 158  VAL V 164 -1  N  TRP V 162   O  VAL V 169           
SHEET    3  BS 4 PHE V 211  PHE V 217 -1  O  ARG V 212   N  TRP V 163           
SHEET    4  BS 4 VAL V 238  ALA V 240 -1  O  VAL V 238   N  VAL V 215           
SSBOND   1 CYS A  107    CYS A  163                          1555   1555  2.04  
SSBOND   2 CYS B   15    CYS B   79                          1555   1555  2.05  
SSBOND   3 CYS B  117    CYS B  173                          1555   1555  2.03  
SSBOND   4 CYS M   22    CYS M   90                          1555   1555  2.04  
SSBOND   5 CYS P   23    CYS P   92                          1555   1555  2.03  
SSBOND   6 CYS P  148    CYS P  213                          1555   1555  2.03  
SSBOND   7 CYS D  107    CYS D  163                          1555   1555  2.04  
SSBOND   8 CYS E   15    CYS E   79                          1555   1555  2.04  
SSBOND   9 CYS E  117    CYS E  173                          1555   1555  2.04  
SSBOND  10 CYS Q   22    CYS Q   90                          1555   1555  2.04  
SSBOND  11 CYS Q  139    CYS Q  189                          1555   1555  2.04  
SSBOND  12 CYS R   23    CYS R   92                          1555   1555  2.03  
SSBOND  13 CYS R  148    CYS R  213                          1555   1555  2.03  
SSBOND  14 CYS G  107    CYS G  163                          1555   1555  2.04  
SSBOND  15 CYS H   15    CYS H   79                          1555   1555  2.03  
SSBOND  16 CYS H  117    CYS H  173                          1555   1555  2.03  
SSBOND  17 CYS S   22    CYS S   90                          1555   1555  2.03  
SSBOND  18 CYS T   23    CYS T   92                          1555   1555  2.03  
SSBOND  19 CYS T  148    CYS T  213                          1555   1555  2.04  
SSBOND  20 CYS J  107    CYS J  163                          1555   1555  2.04  
SSBOND  21 CYS K   15    CYS K   79                          1555   1555  2.04  
SSBOND  22 CYS K  117    CYS K  173                          1555   1555  2.03  
SSBOND  23 CYS U   22    CYS U   90                          1555   1555  2.04  
SSBOND  24 CYS U  139    CYS U  189                          1555   1555  2.04  
SSBOND  25 CYS V   23    CYS V   92                          1555   1555  2.04  
SSBOND  26 CYS V  148    CYS V  213                          1555   1555  2.04  
CISPEP   1 ASN A   15    PRO A   16          0         0.04                     
CISPEP   2 THR A  113    PRO A  114          0        -0.02                     
CISPEP   3 TYR B  123    PRO B  124          0         0.89                     
CISPEP   4 THR P    7    PRO P    8          0        -0.55                     
CISPEP   5 TYR P  154    PRO P  155          0        -0.05                     
CISPEP   6 ASN D   15    PRO D   16          0         0.01                     
CISPEP   7 THR D  113    PRO D  114          0        -3.73                     
CISPEP   8 TYR E  123    PRO E  124          0         0.09                     
CISPEP   9 THR R    7    PRO R    8          0         0.15                     
CISPEP  10 TYR R  154    PRO R  155          0         0.03                     
CISPEP  11 ASN G   15    PRO G   16          0        -0.16                     
CISPEP  12 THR G  113    PRO G  114          0         4.20                     
CISPEP  13 TYR H  123    PRO H  124          0         0.06                     
CISPEP  14 THR T    7    PRO T    8          0         1.23                     
CISPEP  15 TYR T  154    PRO T  155          0        -0.11                     
CISPEP  16 ASN J   15    PRO J   16          0         0.23                     
CISPEP  17 THR J  113    PRO J  114          0        -0.03                     
CISPEP  18 TYR K  123    PRO K  124          0         2.45                     
CISPEP  19 THR V    7    PRO V    8          0        -0.21                     
CISPEP  20 TYR V  154    PRO V  155          0        -0.36                     
CRYST1   96.480   97.690  124.020  74.39  83.19  61.55 P 1           4          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.010365 -0.005616  0.000134        0.00000                         
SCALE2      0.000000  0.011642 -0.002923        0.00000                         
SCALE3      0.000000  0.000000  0.008373        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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