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Database: PDB
Entry: 2CKJ
LinkDB: 2CKJ
Original site: 2CKJ 
HEADER    OXIDOREDUCTASE                          19-APR-06   2CKJ              
TITLE     HUMAN MILK XANTHINE OXIDOREDUCTASE                                    
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: XANTHINE OXIDOREDUCTASE;                                   
COMPND   3 CHAIN: A, B, C, D;                                                   
COMPND   4 SYNONYM: XDH, XANTHINE DEHYDROGENASE, XO, XANTHINE                   
COMPND   5  OXIDASE, OXIDOREDUCTASE;                                            
COMPND   6 EC: 1.1.1.204, 1.2.3.2, 1.17.3.2                                     
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 TISSUE: BREAST MILK;                                                 
SOURCE   6 OTHER_DETAILS: MILK KINDLY DONATED BY MOTHERS AT THE                 
SOURCE   7  INTENSIVE CARE BABY UNITS AT THE BRISTOL ROYAL INFIRMARY            
SOURCE   8  AND SOUTHMEAD HOSPITAL, BRISTOL, UK                                 
KEYWDS    FAD, NAD, IRON, 2FE-2S, MOLYBDENUM, PEROXISOME, REVERSIBLE            
KEYWDS   2 INTERCONVERSION, XANTHINE DEHYDROGENASE, XANTHINE                    
KEYWDS   3 OXIDOREDUCTASE, OXIDOREDUCTASE, XANTHINE OXIDASE, IRON-              
KEYWDS   4 SULFUR, POLYMORPHISM, FLAVOPROTEIN, METAL-BINDING                    
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    A.R.PEARSON,B.L.J.GODBER,R.EISENTHAL,G.L.TAYLOR,R.HARRISON            
REVDAT   2   24-FEB-09 2CKJ    1       VERSN                                    
REVDAT   1   29-MAY-07 2CKJ    0                                                
JRNL        AUTH   A.R.PEARSON,B.L.J.GODBER,R.EISENTHAL,G.L.TAYLOR,             
JRNL        AUTH 2 R.HARRISON                                                   
JRNL        TITL   HUMAN MILK XANTHINE DEHYDROGENASE IS INCOMPLETELY            
JRNL        TITL 2 CONVERTED TO THE OXIDASE FORM IN THE ABSENCE OF              
JRNL        TITL 3 PROTEOLYSIS. A STRUCTURAL EXPLANATION.                       
JRNL        REF    TO BE PUBLISHED                                              
JRNL        REFN                                                                
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.59 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : REFMAC 5.2.0005                                      
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON                               
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.59                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 30.76                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NULL                           
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.2                           
REMARK   3   NUMBER OF REFLECTIONS             : 70696                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.182                           
REMARK   3   R VALUE            (WORKING SET) : 0.178                           
REMARK   3   FREE R VALUE                     : 0.258                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 3745                            
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 20                           
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 3.59                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 3.68                         
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 4917                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : NULL                         
REMARK   3   BIN R VALUE           (WORKING SET) : 0.1810                       
REMARK   3   BIN FREE R VALUE SET COUNT          : 244                          
REMARK   3   BIN FREE R VALUE                    : 0.2770                       
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 39530                                   
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 277                                     
REMARK   3   SOLVENT ATOMS            : 0                                       
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 22.75                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 0.00000                                              
REMARK   3    B22 (A**2) : 0.00000                                              
REMARK   3    B33 (A**2) : 0.00000                                              
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.                                 
REMARK   3   ESU BASED ON R VALUE                            (A): NULL          
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.710         
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.511         
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 68.993        
REMARK   3                                                                      
REMARK   3 CORRELATION COEFFICIENTS.                                            
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.916                         
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.841                         
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT      
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 40686 ; 0.045 ; 0.022       
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 55080 ; 3.461 ; 1.972       
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL       
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  5101 ;15.080 ; 5.000       
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):  1681 ;40.738 ;23.968       
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  6980 ;25.790 ;15.000       
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):   242 ;22.106 ;15.000       
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  6192 ; 0.221 ; 0.200       
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 30316 ; 0.012 ; 0.020       
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A): 16918 ; 0.317 ; 0.200       
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A): 26141 ; 0.354 ; 0.200       
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  1154 ; 0.218 ; 0.200       
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):   110 ; 0.360 ; 0.200       
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):     8 ; 0.182 ; 0.200       
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT      
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2): 27044 ; 1.193 ; 1.500       
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 41134 ; 1.759 ; 2.000       
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2): 16864 ; 2.564 ; 3.000       
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2): 13890 ; 3.993 ; 4.500       
REMARK   3                                                                      
REMARK   3 ANISOTROPIC THERMAL FACTOR RESTRAINTS.    COUNT   RMS   WEIGHT       
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS STATISTICS                                           
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : 1                                 
REMARK   3                                                                      
REMARK   3  NCS GROUP NUMBER               : 1                                  
REMARK   3     CHAIN NAMES                    : A B C D                         
REMARK   3     NUMBER OF COMPONENTS NCS GROUP : 7                               
REMARK   3       COMPONENT C  SSSEQI  TO  C   SSSEQI   CODE                     
REMARK   3           1     A      6       A     422      1                      
REMARK   3           1     B      6       B     422      1                      
REMARK   3           1     C      6       C     422      1                      
REMARK   3           1     D      6       D     422      1                      
REMARK   3           2     A    435       A     503      1                      
REMARK   3           2     B    435       B     503      1                      
REMARK   3           2     C    435       C     503      1                      
REMARK   3           2     D    435       D     503      1                      
REMARK   3           3     A    515       A     523      1                      
REMARK   3           3     B    515       B     523      1                      
REMARK   3           3     C    515       C     523      1                      
REMARK   3           3     D    515       D     523      1                      
REMARK   3           4     A    557       A     590      1                      
REMARK   3           4     B    557       B     590      1                      
REMARK   3           4     C    557       C     590      1                      
REMARK   3           4     D    557       D     590      1                      
REMARK   3           5     A    600       A     745      1                      
REMARK   3           5     B    600       B     745      1                      
REMARK   3           5     C    600       C     745      1                      
REMARK   3           5     D    600       D     745      1                      
REMARK   3           6     A    755       A    1310      1                      
REMARK   3           6     B    755       B    1310      1                      
REMARK   3           6     C    755       C    1310      1                      
REMARK   3           6     D    755       D    1310      1                      
REMARK   3           7     A   3001       A    3006      1                      
REMARK   3           7     B   3001       B    3006      1                      
REMARK   3           7     C   3001       C    3006      1                      
REMARK   3           7     D   3001       D    3006      1                      
REMARK   3                   GROUP CHAIN        COUNT   RMS     WEIGHT          
REMARK   3   TIGHT POSITIONAL   1    A    (A):   9345 ;  0.14 ;  0.05           
REMARK   3   TIGHT POSITIONAL   1    B    (A):   9345 ;  0.14 ;  0.05           
REMARK   3   TIGHT POSITIONAL   1    C    (A):   9345 ;  0.14 ;  0.05           
REMARK   3   TIGHT POSITIONAL   1    D    (A):   9345 ;  0.15 ;  0.05           
REMARK   3   TIGHT THERMAL      1    A (A**2):   9345 ;  0.25 ;  0.50           
REMARK   3   TIGHT THERMAL      1    B (A**2):   9345 ;  0.25 ;  0.50           
REMARK   3   TIGHT THERMAL      1    C (A**2):   9345 ;  0.26 ;  0.50           
REMARK   3   TIGHT THERMAL      1    D (A**2):   9345 ;  0.26 ;  0.50           
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 4                                          
REMARK   3                                                                      
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A     2        A  1318                          
REMARK   3    ORIGIN FOR THE GROUP (A):  88.7870  89.3940 137.1520              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.4447 T22:  -0.4512                                     
REMARK   3      T33:  -0.5053 T12:   0.0333                                     
REMARK   3      T13:  -0.0290 T23:   0.0442                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.5155 L22:   0.6817                                     
REMARK   3      L33:   0.3800 L12:   0.2349                                     
REMARK   3      L13:  -0.1480 L23:   0.1051                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0058 S12:  -0.1876 S13:  -0.2273                       
REMARK   3      S21:  -0.1216 S22:   0.0291 S23:  -0.1961                       
REMARK   3      S31:   0.0942 S32:   0.1721 S33:  -0.0233                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B     2        B  1318                          
REMARK   3    ORIGIN FOR THE GROUP (A): -25.1450 139.3380 101.5330              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.5014 T22:  -0.5842                                     
REMARK   3      T33:  -0.4620 T12:   0.0032                                     
REMARK   3      T13:  -0.0484 T23:   0.0071                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.8937 L22:   0.8879                                     
REMARK   3      L33:   0.3109 L12:  -0.1702                                     
REMARK   3      L13:  -0.0151 L23:  -0.0863                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0176 S12:  -0.0546 S13:  -0.3802                       
REMARK   3      S21:  -0.0422 S22:  -0.0254 S23:  -0.0033                       
REMARK   3      S31:   0.0805 S32:   0.0032 S33:   0.0079                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   C     2        C  1318                          
REMARK   3    ORIGIN FOR THE GROUP (A):   4.9680  58.1330 112.0020              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.4751 T22:  -0.5883                                     
REMARK   3      T33:  -0.4427 T12:   0.0464                                     
REMARK   3      T13:  -0.1349 T23:  -0.0738                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6626 L22:   0.7838                                     
REMARK   3      L33:   0.4619 L12:  -0.2858                                     
REMARK   3      L13:   0.0367 L23:  -0.0993                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0539 S12:  -0.0412 S13:   0.1360                       
REMARK   3      S21:   0.1564 S22:   0.0506 S23:  -0.3596                       
REMARK   3      S31:   0.0251 S32:   0.1251 S33:   0.0033                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D     2        D  1318                          
REMARK   3    ORIGIN FOR THE GROUP (A): -49.1890  24.0340 125.0440              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.2750 T22:  -0.5264                                     
REMARK   3      T33:  -0.5614 T12:  -0.0743                                     
REMARK   3      T13:  -0.1325 T23:   0.0381                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2503 L22:   0.8149                                     
REMARK   3      L33:   0.5802 L12:  -0.0031                                     
REMARK   3      L13:  -0.0785 L23:  -0.1683                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0141 S12:   0.0100 S13:  -0.0078                       
REMARK   3      S21:  -0.0688 S22:   0.0619 S23:   0.1878                       
REMARK   3      S31:   0.2281 S32:  -0.1993 S33:  -0.0478                       
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED : BABINET MODEL WITH MASK                              
REMARK   3   PARAMETERS FOR MASK CALCULATION                                    
REMARK   3   VDW PROBE RADIUS   : 1.20                                          
REMARK   3   ION PROBE RADIUS   : 0.80                                          
REMARK   3   SHRINKAGE RADIUS   : 0.80                                          
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE          
REMARK   3  RIDING POSITIONS. RESIDUES A1-2, A166-192, A426-429, A534-557,      
REMARK   3  A1231-A1328, A1330-1333, B1, B166-192, B548-556, B1320-1325,        
REMARK   3  B1333, C1-2, C166-192, C429-431, C548-556, C1320-1327, C1333,       
REMARK   3  D1-2, D166-192, D542-556, D1321-1325, D1333 ARE NOT PRESENT IN      
REMARK   3  THE ELECTRON DENSITY.                                               
REMARK   4                                                                      
REMARK   4 2CKJ COMPLIES WITH FORMAT V. 3.15, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 20-APR-06.                  
REMARK 100 THE PDBE ID CODE IS EBI-28500.                                       
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : NULL                               
REMARK 200  TEMPERATURE           (KELVIN) : 100.0                              
REMARK 200  PH                             : 6.00                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : ESRF                               
REMARK 200  BEAMLINE                       : ID14-2                             
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9326                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : MARRESEARCH                        
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : DENZO                              
REMARK 200  DATA SCALING SOFTWARE          : SCALA                              
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 75088                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.500                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 30.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 1.500                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.2                               
REMARK 200  DATA REDUNDANCY                : 4.400                              
REMARK 200  R MERGE                    (I) : 0.12000                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 3.6000                             
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.50                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.62                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 95.3                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.50                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.47000                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 1.500                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: AMORE                                                 
REMARK 200 STARTING MODEL: PDB ENTRY 1FO4                                       
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 53.8                                      
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.7                      
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 26% (W/V) PEG 4K, 0.1M SODIUM            
REMARK 280  ACETATE, PH 6, 0.25M AMMONIUM ACETATE, 10MM DTT, 10% (W/V)          
REMARK 280  GLUCOSE                                                             
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 31 2 1                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -Y,X-Y,Z+1/3                                            
REMARK 290       3555   -X+Y,-X,Z+2/3                                           
REMARK 290       4555   Y,X,-Z                                                  
REMARK 290       5555   X-Y,-Y,-Z+2/3                                           
REMARK 290       6555   -X,-X+Y,-Z+1/3                                          
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       95.17933            
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000      190.35867            
REMARK 290   SMTRY1   4 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   4  0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   5  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000      190.35867            
REMARK 290   SMTRY1   6 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   6 -0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000       95.17933            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2, 3                                                 
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY.  THE REMARK MAY ALSO PROVIDE INFORMATION ON              
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 GENERATING THE BIOMOLECULE                                           
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE:  1                                                      
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PQS                                                   
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350   BIOMT1   2 -0.500000  0.866025 -0.000000        0.00000            
REMARK 350   BIOMT2   2  0.866025  0.500000 -0.000000        0.00000            
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000      285.53800            
REMARK 350 BIOMOLECULE:  2                                                      
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PQS                                                   
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350   BIOMT1   2  1.000000 -0.000000 -0.000000        0.00000            
REMARK 350   BIOMT2   2  0.000000 -1.000000  0.000000      342.48533            
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000      190.35867            
REMARK 350 BIOMOLECULE:  3                                                      
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PQS                                                   
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     THR A     2                                                      
REMARK 465     ASP A   166                                                      
REMARK 465     GLY A   167                                                      
REMARK 465     GLY A   168                                                      
REMARK 465     CYS A   169                                                      
REMARK 465     CYS A   170                                                      
REMARK 465     GLY A   171                                                      
REMARK 465     GLY A   172                                                      
REMARK 465     ASP A   173                                                      
REMARK 465     GLY A   174                                                      
REMARK 465     ASN A   175                                                      
REMARK 465     ASN A   176                                                      
REMARK 465     PRO A   177                                                      
REMARK 465     ASN A   178                                                      
REMARK 465     CYS A   179                                                      
REMARK 465     CYS A   180                                                      
REMARK 465     MET A   181                                                      
REMARK 465     ASN A   182                                                      
REMARK 465     GLN A   183                                                      
REMARK 465     LYS A   184                                                      
REMARK 465     LYS A   185                                                      
REMARK 465     ASP A   186                                                      
REMARK 465     HIS A   187                                                      
REMARK 465     SER A   188                                                      
REMARK 465     VAL A   189                                                      
REMARK 465     SER A   190                                                      
REMARK 465     LEU A   191                                                      
REMARK 465     SER A   192                                                      
REMARK 465     ARG A   426                                                      
REMARK 465     ARG A   427                                                      
REMARK 465     GLU A   428                                                      
REMARK 465     ASP A   429                                                      
REMARK 465     ASP A   534                                                      
REMARK 465     LYS A   535                                                      
REMARK 465     CYS A   536                                                      
REMARK 465     GLY A   537                                                      
REMARK 465     LYS A   538                                                      
REMARK 465     LEU A   539                                                      
REMARK 465     ASP A   540                                                      
REMARK 465     PRO A   541                                                      
REMARK 465     THR A   542                                                      
REMARK 465     PHE A   543                                                      
REMARK 465     ALA A   544                                                      
REMARK 465     SER A   545                                                      
REMARK 465     ALA A   546                                                      
REMARK 465     THR A   547                                                      
REMARK 465     LEU A   548                                                      
REMARK 465     LEU A   549                                                      
REMARK 465     PHE A   550                                                      
REMARK 465     GLN A   551                                                      
REMARK 465     LYS A   552                                                      
REMARK 465     ASP A   553                                                      
REMARK 465     PRO A   554                                                      
REMARK 465     PRO A   555                                                      
REMARK 465     ALA A   556                                                      
REMARK 465     ASP A   557                                                      
REMARK 465     GLY A  1321                                                      
REMARK 465     VAL A  1322                                                      
REMARK 465     PRO A  1323                                                      
REMARK 465     GLU A  1324                                                      
REMARK 465     ASN A  1325                                                      
REMARK 465     CYS A  1326                                                      
REMARK 465     LYS A  1327                                                      
REMARK 465     PRO A  1328                                                      
REMARK 465     SER A  1330                                                      
REMARK 465     VAL A  1331                                                      
REMARK 465     ARG A  1332                                                      
REMARK 465     VAL A  1333                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ASP B   166                                                      
REMARK 465     GLY B   167                                                      
REMARK 465     GLY B   168                                                      
REMARK 465     CYS B   169                                                      
REMARK 465     CYS B   170                                                      
REMARK 465     GLY B   171                                                      
REMARK 465     GLY B   172                                                      
REMARK 465     ASP B   173                                                      
REMARK 465     GLY B   174                                                      
REMARK 465     ASN B   175                                                      
REMARK 465     ASN B   176                                                      
REMARK 465     PRO B   177                                                      
REMARK 465     ASN B   178                                                      
REMARK 465     CYS B   179                                                      
REMARK 465     CYS B   180                                                      
REMARK 465     MET B   181                                                      
REMARK 465     ASN B   182                                                      
REMARK 465     GLN B   183                                                      
REMARK 465     LYS B   184                                                      
REMARK 465     LYS B   185                                                      
REMARK 465     ASP B   186                                                      
REMARK 465     HIS B   187                                                      
REMARK 465     SER B   188                                                      
REMARK 465     VAL B   189                                                      
REMARK 465     SER B   190                                                      
REMARK 465     LEU B   191                                                      
REMARK 465     SER B   192                                                      
REMARK 465     LEU B   548                                                      
REMARK 465     LEU B   549                                                      
REMARK 465     PHE B   550                                                      
REMARK 465     GLN B   551                                                      
REMARK 465     LYS B   552                                                      
REMARK 465     ASP B   553                                                      
REMARK 465     PRO B   554                                                      
REMARK 465     PRO B   555                                                      
REMARK 465     ALA B   556                                                      
REMARK 465     THR B  1320                                                      
REMARK 465     GLY B  1321                                                      
REMARK 465     VAL B  1322                                                      
REMARK 465     PRO B  1323                                                      
REMARK 465     GLU B  1324                                                      
REMARK 465     ASN B  1325                                                      
REMARK 465     VAL B  1333                                                      
REMARK 465     MET C     1                                                      
REMARK 465     THR C     2                                                      
REMARK 465     ASP C   166                                                      
REMARK 465     GLY C   167                                                      
REMARK 465     GLY C   168                                                      
REMARK 465     CYS C   169                                                      
REMARK 465     CYS C   170                                                      
REMARK 465     GLY C   171                                                      
REMARK 465     GLY C   172                                                      
REMARK 465     ASP C   173                                                      
REMARK 465     GLY C   174                                                      
REMARK 465     ASN C   175                                                      
REMARK 465     ASN C   176                                                      
REMARK 465     PRO C   177                                                      
REMARK 465     ASN C   178                                                      
REMARK 465     CYS C   179                                                      
REMARK 465     CYS C   180                                                      
REMARK 465     MET C   181                                                      
REMARK 465     ASN C   182                                                      
REMARK 465     GLN C   183                                                      
REMARK 465     LYS C   184                                                      
REMARK 465     LYS C   185                                                      
REMARK 465     ASP C   186                                                      
REMARK 465     HIS C   187                                                      
REMARK 465     SER C   188                                                      
REMARK 465     VAL C   189                                                      
REMARK 465     SER C   190                                                      
REMARK 465     LEU C   191                                                      
REMARK 465     SER C   192                                                      
REMARK 465     ASP C   429                                                      
REMARK 465     ASP C   430                                                      
REMARK 465     ILE C   431                                                      
REMARK 465     LEU C   548                                                      
REMARK 465     LEU C   549                                                      
REMARK 465     PHE C   550                                                      
REMARK 465     GLN C   551                                                      
REMARK 465     LYS C   552                                                      
REMARK 465     ASP C   553                                                      
REMARK 465     PRO C   554                                                      
REMARK 465     PRO C   555                                                      
REMARK 465     ALA C   556                                                      
REMARK 465     THR C  1320                                                      
REMARK 465     GLY C  1321                                                      
REMARK 465     VAL C  1322                                                      
REMARK 465     PRO C  1323                                                      
REMARK 465     GLU C  1324                                                      
REMARK 465     ASN C  1325                                                      
REMARK 465     CYS C  1326                                                      
REMARK 465     LYS C  1327                                                      
REMARK 465     VAL C  1333                                                      
REMARK 465     MET D     1                                                      
REMARK 465     THR D     2                                                      
REMARK 465     ASP D   166                                                      
REMARK 465     GLY D   167                                                      
REMARK 465     GLY D   168                                                      
REMARK 465     CYS D   169                                                      
REMARK 465     CYS D   170                                                      
REMARK 465     GLY D   171                                                      
REMARK 465     GLY D   172                                                      
REMARK 465     ASP D   173                                                      
REMARK 465     GLY D   174                                                      
REMARK 465     ASN D   175                                                      
REMARK 465     ASN D   176                                                      
REMARK 465     PRO D   177                                                      
REMARK 465     ASN D   178                                                      
REMARK 465     CYS D   179                                                      
REMARK 465     CYS D   180                                                      
REMARK 465     MET D   181                                                      
REMARK 465     ASN D   182                                                      
REMARK 465     GLN D   183                                                      
REMARK 465     LYS D   184                                                      
REMARK 465     LYS D   185                                                      
REMARK 465     ASP D   186                                                      
REMARK 465     HIS D   187                                                      
REMARK 465     SER D   188                                                      
REMARK 465     VAL D   189                                                      
REMARK 465     SER D   190                                                      
REMARK 465     LEU D   191                                                      
REMARK 465     SER D   192                                                      
REMARK 465     THR D   542                                                      
REMARK 465     PHE D   543                                                      
REMARK 465     ALA D   544                                                      
REMARK 465     SER D   545                                                      
REMARK 465     ALA D   546                                                      
REMARK 465     THR D   547                                                      
REMARK 465     LEU D   548                                                      
REMARK 465     LEU D   549                                                      
REMARK 465     PHE D   550                                                      
REMARK 465     GLN D   551                                                      
REMARK 465     LYS D   552                                                      
REMARK 465     ASP D   553                                                      
REMARK 465     PRO D   554                                                      
REMARK 465     PRO D   555                                                      
REMARK 465     ALA D   556                                                      
REMARK 465     GLY D  1321                                                      
REMARK 465     VAL D  1322                                                      
REMARK 465     PRO D  1323                                                      
REMARK 465     GLU D  1324                                                      
REMARK 465     ASN D  1325                                                      
REMARK 465     VAL D  1333                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ARG B1332    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG C1332    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG D1332    CG   CD   NE   CZ   NH1  NH2                        
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    LEU A   219  -  N    ASP A   221              2.13            
REMARK 500   OG   SER A   399  -  OE1  GLU A   401              2.15            
REMARK 500   NH2  ARG A   439  -  OE1  GLU A   451              2.15            
REMARK 500   O    THR A   698  -  O    GLU A   700              1.90            
REMARK 500   O    ASP A   701  -  N    ILE A   703              2.10            
REMARK 500   OE1  GLU A  1210  -  OH   TYR A  1228              1.98            
REMARK 500   O    THR B     2  -  OD1  ASP B     4              1.78            
REMARK 500   O    LEU B   219  -  N    ASP B   221              1.97            
REMARK 500   CG   ASP B   430  -  CE   LYS B  1229              2.17            
REMARK 500   OD2  ASP B   430  -  CD   LYS B  1229              1.88            
REMARK 500   O    THR B   698  -  O    GLU B   700              1.90            
REMARK 500   O    ASP B   701  -  N    ILE B   703              2.00            
REMARK 500   O    ALA B   980  -  N    LYS B   982              2.16            
REMARK 500   OE1  GLU B  1210  -  OH   TYR B  1228              2.02            
REMARK 500   CB   ASN B  1289  -  NH1  ARG C   380              1.90            
REMARK 500   O    LEU C   219  -  N    ASP C   221              2.10            
REMARK 500   O    THR C   698  -  O    GLU C   700              2.19            
REMARK 500   O    ASP C   701  -  N    ILE C   703              2.02            
REMARK 500   O    GLY D   159  -  CG2  THR D   162              2.03            
REMARK 500   O    LEU D   219  -  N    ASP D   221              2.04            
REMARK 500   N    LEU D   404  -  N6A  FAD D  3006              2.20            
REMARK 500   NH2  ARG D   439  -  OE1  GLU D   451              2.15            
REMARK 500   O    THR D   698  -  O    GLU D   700              2.15            
REMARK 500   O    ILE D   699  -  CB   ALA D   702              2.16            
REMARK 500   O    ASP D   701  -  N    ILE D   703              2.05            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    VAL A   7   CB    VAL A   7   CG1    -0.175                       
REMARK 500    VAL A   7   CB    VAL A   7   CG2    -0.182                       
REMARK 500    ARG A  13   CG    ARG A  13   CD      0.151                       
REMARK 500    VAL A  16   CA    VAL A  16   CB     -0.135                       
REMARK 500    VAL A  16   CB    VAL A  16   CG2    -0.164                       
REMARK 500    ASP A  21   CB    ASP A  21   CG      0.133                       
REMARK 500    GLU A  23   CD    GLU A  23   OE2     0.076                       
REMARK 500    LEU A  27   C     LEU A  27   O       0.118                       
REMARK 500    ALA A  28   CA    ALA A  28   CB      0.138                       
REMARK 500    LYS A  33   CD    LYS A  33   CE      0.154                       
REMARK 500    LYS A  40   CD    LYS A  40   CE      0.197                       
REMARK 500    MET A  54   CG    MET A  54   SD      0.193                       
REMARK 500    GLN A  62   CG    GLN A  62   CD      0.167                       
REMARK 500    LYS A  64   CD    LYS A  64   CE      0.228                       
REMARK 500    LYS A  64   CG    LYS A  64   CD      0.210                       
REMARK 500    HIS A  67   N     HIS A  67   CA      0.122                       
REMARK 500    CYS A  78   CB    CYS A  78   SG      0.278                       
REMARK 500    VAL A  83   CB    VAL A  83   CG1    -0.209                       
REMARK 500    LYS A  95   CD    LYS A  95   CE      0.181                       
REMARK 500    LYS A  95   CE    LYS A  95   NZ      0.163                       
REMARK 500    GLU A 103   CG    GLU A 103   CD      0.096                       
REMARK 500    LYS A 107   CD    LYS A 107   CE      0.177                       
REMARK 500    GLN A 112   CG    GLN A 112   CD      0.157                       
REMARK 500    GLU A 133   CD    GLU A 133   OE1     0.067                       
REMARK 500    GLU A 133   CG    GLU A 133   CD      0.124                       
REMARK 500    GLU A 137   CG    GLU A 137   CD      0.103                       
REMARK 500    GLU A 138   CG    GLU A 138   CD      0.108                       
REMARK 500    GLU A 140   CB    GLU A 140   CG      0.120                       
REMARK 500    GLU A 140   CD    GLU A 140   OE1     0.071                       
REMARK 500    CYS A 150   CB    CYS A 150   SG     -0.177                       
REMARK 500    ARG A 161   CB    ARG A 161   CG      0.173                       
REMARK 500    ARG A 161   CG    ARG A 161   CD      0.192                       
REMARK 500    GLU A 199   CB    GLU A 199   CG      0.120                       
REMARK 500    GLU A 199   CG    GLU A 199   CD      0.091                       
REMARK 500    GLU A 200   CB    GLU A 200   CG      0.145                       
REMARK 500    GLU A 200   CD    GLU A 200   OE2     0.079                       
REMARK 500    GLU A 200   CG    GLU A 200   CD      0.101                       
REMARK 500    GLU A 215   CD    GLU A 215   OE1     0.089                       
REMARK 500    GLU A 230   CD    GLU A 230   OE1     0.069                       
REMARK 500    GLU A 230   CD    GLU A 230   OE2     0.070                       
REMARK 500    GLU A 232   CG    GLU A 232   CD      0.153                       
REMARK 500    TRP A 236   CE2   TRP A 236   CZ2    -0.104                       
REMARK 500    VAL A 258   CA    VAL A 258   CB     -0.141                       
REMARK 500    LYS A 269   CD    LYS A 269   CE      0.203                       
REMARK 500    VAL A 279   CB    VAL A 279   CG2    -0.136                       
REMARK 500    TRP A 283   CG    TRP A 283   CD1    -0.116                       
REMARK 500    GLU A 291   CG    GLU A 291   CD      0.098                       
REMARK 500    GLU A 309   CB    GLU A 309   CG      0.115                       
REMARK 500    GLU A 309   CD    GLU A 309   OE1     0.090                       
REMARK 500    GLU A 309   CD    GLU A 309   OE2     0.108                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LEU A   6   CB  -  CG  -  CD2 ANGL. DEV. = -12.5 DEGREES          
REMARK 500    ASP A  21   CB  -  CG  -  OD2 ANGL. DEV. =  -7.5 DEGREES          
REMARK 500    LYS A  40   CD  -  CE  -  NZ  ANGL. DEV. =  17.6 DEGREES          
REMARK 500    LYS A  64   O   -  C   -  N   ANGL. DEV. =  -9.7 DEGREES          
REMARK 500    ARG A  97   NE  -  CZ  -  NH1 ANGL. DEV. =   4.5 DEGREES          
REMARK 500    ARG A 129   NE  -  CZ  -  NH1 ANGL. DEV. =   3.2 DEGREES          
REMARK 500    ARG A 149   NE  -  CZ  -  NH2 ANGL. DEV. =   5.5 DEGREES          
REMARK 500    ARG A 161   NE  -  CZ  -  NH1 ANGL. DEV. =   4.8 DEGREES          
REMARK 500    ARG A 161   NE  -  CZ  -  NH2 ANGL. DEV. =  -4.7 DEGREES          
REMARK 500    ARG A 165   N   -  CA  -  CB  ANGL. DEV. =  11.4 DEGREES          
REMARK 500    ARG A 165   NE  -  CZ  -  NH2 ANGL. DEV. =   4.0 DEGREES          
REMARK 500    SER A 194   N   -  CA  -  C   ANGL. DEV. =  20.3 DEGREES          
REMARK 500    LEU A 195   N   -  CA  -  C   ANGL. DEV. =  17.0 DEGREES          
REMARK 500    PRO A 203   C   -  N   -  CA  ANGL. DEV. =  15.4 DEGREES          
REMARK 500    PRO A 214   C   -  N   -  CA  ANGL. DEV. = -13.7 DEGREES          
REMARK 500    GLU A 215   OE1 -  CD  -  OE2 ANGL. DEV. =   8.4 DEGREES          
REMARK 500    LEU A 216   N   -  CA  -  C   ANGL. DEV. = -20.8 DEGREES          
REMARK 500    LEU A 219   CB  -  CG  -  CD2 ANGL. DEV. =  10.7 DEGREES          
REMARK 500    LEU A 227   CB  -  CG  -  CD2 ANGL. DEV. = -10.6 DEGREES          
REMARK 500    MET A 277   CG  -  SD  -  CE  ANGL. DEV. =  13.9 DEGREES          
REMARK 500    CYS A 303   CB  -  CA  -  C   ANGL. DEV. =  -8.2 DEGREES          
REMARK 500    LEU A 312   CB  -  CG  -  CD2 ANGL. DEV. =  10.8 DEGREES          
REMARK 500    VAL A 313   CB  -  CA  -  C   ANGL. DEV. = -12.8 DEGREES          
REMARK 500    LYS A 318   CD  -  CE  -  NZ  ANGL. DEV. =  14.7 DEGREES          
REMARK 500    LEU A 334   CB  -  CG  -  CD1 ANGL. DEV. = -11.7 DEGREES          
REMARK 500    VAL A 345   N   -  CA  -  C   ANGL. DEV. =  16.8 DEGREES          
REMARK 500    VAL A 348   CB  -  CA  -  C   ANGL. DEV. = -12.4 DEGREES          
REMARK 500    LEU A 361   CB  -  CG  -  CD2 ANGL. DEV. = -14.7 DEGREES          
REMARK 500    LEU A 372   CB  -  CG  -  CD2 ANGL. DEV. =  10.5 DEGREES          
REMARK 500    ARG A 377   NE  -  CZ  -  NH1 ANGL. DEV. =   3.1 DEGREES          
REMARK 500    ARG A 381   NE  -  CZ  -  NH1 ANGL. DEV. =   3.1 DEGREES          
REMARK 500    ARG A 394   NE  -  CZ  -  NH1 ANGL. DEV. =   4.2 DEGREES          
REMARK 500    ARG A 394   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.4 DEGREES          
REMARK 500    LEU A 467   N   -  CA  -  C   ANGL. DEV. =  16.6 DEGREES          
REMARK 500    CYS A 509   CA  -  CB  -  SG  ANGL. DEV. =  -9.8 DEGREES          
REMARK 500    LEU A 521   CB  -  CG  -  CD2 ANGL. DEV. = -14.4 DEGREES          
REMARK 500    PRO A 577   C   -  N   -  CA  ANGL. DEV. =   9.5 DEGREES          
REMARK 500    VAL A 592   CB  -  CA  -  C   ANGL. DEV. = -14.0 DEGREES          
REMARK 500    CYS A 594   CA  -  CB  -  SG  ANGL. DEV. =  -8.3 DEGREES          
REMARK 500    ARG A 599   NE  -  CZ  -  NH1 ANGL. DEV. =   4.0 DEGREES          
REMARK 500    ARG A 599   NE  -  CZ  -  NH2 ANGL. DEV. =  -4.8 DEGREES          
REMARK 500    ARG A 607   NE  -  CZ  -  NH1 ANGL. DEV. =  -4.4 DEGREES          
REMARK 500    LEU A 608   CB  -  CG  -  CD2 ANGL. DEV. = -11.3 DEGREES          
REMARK 500    ASP A 640   CB  -  CG  -  OD1 ANGL. DEV. =  -7.3 DEGREES          
REMARK 500    THR A 654   CB  -  CA  -  C   ANGL. DEV. = -16.7 DEGREES          
REMARK 500    ASP A 674   CB  -  CG  -  OD1 ANGL. DEV. =   6.7 DEGREES          
REMARK 500    ARG A 681   NE  -  CZ  -  NH1 ANGL. DEV. =   5.5 DEGREES          
REMARK 500    ARG A 681   NE  -  CZ  -  NH2 ANGL. DEV. =  -5.4 DEGREES          
REMARK 500    GLY A 685   N   -  CA  -  C   ANGL. DEV. =  21.2 DEGREES          
REMARK 500    VAL A 686   CG1 -  CB  -  CG2 ANGL. DEV. = -10.7 DEGREES          
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     445 ANGLE DEVIATIONS                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASP A   4      -46.38   -132.42                                   
REMARK 500    ASN A  19       26.03   -153.71                                   
REMARK 500    ALA A  28      -51.24    119.48                                   
REMARK 500    ARG A  60      -42.91     90.10                                   
REMARK 500    ASN A  63       70.27     22.16                                   
REMARK 500    THR A  96      -87.63   -146.19                                   
REMARK 500    GLN A 112      -92.40    -85.16                                   
REMARK 500    GLN A 131       94.94   -167.28                                   
REMARK 500    GLU A 140       -0.34    -57.12                                   
REMARK 500    ASN A 141      -19.33   -166.38                                   
REMARK 500    TYR A 153      -41.11     80.25                                   
REMARK 500    THR A 162      -33.01    -29.82                                   
REMARK 500    LEU A 204      105.06     95.61                                   
REMARK 500    LEU A 217      -43.07     93.65                                   
REMARK 500    LEU A 219     -103.98    -70.50                                   
REMARK 500    LYS A 220      -13.46     37.60                                   
REMARK 500    ASP A 221      -75.52   -111.87                                   
REMARK 500    THR A 222       86.65    -27.00                                   
REMARK 500    ARG A 233      -28.56   -149.42                                   
REMARK 500    HIS A 252       66.54   -152.79                                   
REMARK 500    ASN A 272       40.52    -11.84                                   
REMARK 500    PRO A 281     -117.88    -73.31                                   
REMARK 500    ALA A 282      -28.30     83.77                                   
REMARK 500    LEU A 305      -54.09    -29.46                                   
REMARK 500    LYS A 318       32.87    -96.51                                   
REMARK 500    PRO A 320      113.88    -27.69                                   
REMARK 500    ALA A 321       30.12    -68.50                                   
REMARK 500    THR A 324       39.64    -84.38                                   
REMARK 500    ALA A 355       92.89    -60.91                                   
REMARK 500    ARG A 380       55.51   -145.11                                   
REMARK 500    TYR A 393      105.96    -58.23                                   
REMARK 500    THR A 396     -160.99   -125.82                                   
REMARK 500    ALA A 424     -126.18   -107.66                                   
REMARK 500    ALA A 432      173.24     77.26                                   
REMARK 500    LYS A 433     -170.63     51.66                                   
REMARK 500    GLU A 448      -62.27   -163.50                                   
REMARK 500    VAL A 449       86.58    115.10                                   
REMARK 500    ALA A 466      -51.29     -4.24                                   
REMARK 500    GLN A 471      -80.17    -40.35                                   
REMARK 500    ARG A 472      -35.78    -35.60                                   
REMARK 500    SER A 475       65.00     37.02                                   
REMARK 500    LYS A 476     -141.94   -104.56                                   
REMARK 500    TRP A 478       89.62    -66.11                                   
REMARK 500    LEU A 494       51.43    -96.02                                   
REMARK 500    CYS A 509      -74.48    -68.31                                   
REMARK 500    THR A 510      -38.44    -33.96                                   
REMARK 500    GLN A 529       40.61   -141.15                                   
REMARK 500    GLU A 530       85.33    -14.81                                   
REMARK 500    LEU A 532      -84.87    -74.29                                   
REMARK 500    PRO A 565      123.03    -15.63                                   
REMARK 500    GLN A 568      153.88    -35.64                                   
REMARK 500    HIS A 580      105.34    -20.61                                   
REMARK 500    LEU A 581      -18.19    -23.30                                   
REMARK 500    ALA A 582       20.68   -141.27                                   
REMARK 500    TYR A 593     -128.00    -95.25                                   
REMARK 500    CYS A 594      -69.67    -97.20                                   
REMARK 500    ASP A 595       15.68    -58.65                                   
REMARK 500    ARG A 607      129.22    151.38                                   
REMARK 500    LYS A 627       -2.96    -53.44                                   
REMARK 500    CYS A 634      151.70    175.53                                   
REMARK 500    SER A 644      118.65   -175.17                                   
REMARK 500    ASN A 651       20.54     37.33                                   
REMARK 500    ASP A 659      -31.57     79.91                                   
REMARK 500    HIS A 666      128.19     32.55                                   
REMARK 500    ALA A 683      -31.68    -22.28                                   
REMARK 500    ILE A 697      -66.58   -121.56                                   
REMARK 500    ASP A 701     -129.50     70.19                                   
REMARK 500    ALA A 702      -71.64     25.01                                   
REMARK 500    ASN A 706       87.10     43.42                                   
REMARK 500    SER A 707      -77.28    -77.34                                   
REMARK 500    GLU A 712      115.72    -20.25                                   
REMARK 500    ASP A 719      135.91    120.65                                   
REMARK 500    LEU A 720      -50.61    179.47                                   
REMARK 500    PHE A 724      -59.10     73.54                                   
REMARK 500    PHE A 743       70.00     38.36                                   
REMARK 500    CYS A 749     -175.63    179.39                                   
REMARK 500    THR A 750      111.09   -162.28                                   
REMARK 500    THR A 804      -42.64   -143.72                                   
REMARK 500    SER A 806      -43.72    -24.61                                   
REMARK 500    LEU A 835      -70.35    -72.24                                   
REMARK 500    SER A 866       99.73     -4.93                                   
REMARK 500    ASP A 873     -157.60     51.97                                   
REMARK 500    LEU A 874       -4.26    -49.78                                   
REMARK 500    PHE A 884      -12.85    -44.84                                   
REMARK 500    ASN A 888     -117.28     47.71                                   
REMARK 500    ILE A 892       83.77   -172.70                                   
REMARK 500    ASN A 905       46.01    -86.94                                   
REMARK 500    MET A 921       87.88    -66.02                                   
REMARK 500    LEU A 922      -49.30    159.93                                   
REMARK 500    ILE A 923      -85.06    -57.75                                   
REMARK 500    GLU A 925       31.16    125.57                                   
REMARK 500    CYS A 926      -86.59   -148.44                                   
REMARK 500    TRP A 927      -72.07     11.73                                   
REMARK 500    VAL A 931      -83.32    -43.96                                   
REMARK 500    ALA A 932      -19.87    -35.01                                   
REMARK 500    MET A 937      -98.49    -80.58                                   
REMARK 500    PRO A 938      141.22    -33.56                                   
REMARK 500    TYR A 948      151.32    -36.88                                   
REMARK 500    ALA A 974      -81.90    -67.40                                   
REMARK 500    GLN A 977       74.58     47.75                                   
REMARK 500    TYR A 978      -79.62    -59.30                                   
REMARK 500    HIS A 979      101.37    -59.70                                   
REMARK 500    ALA A 980      -42.35   -140.27                                   
REMARK 500    ARG A 981      -50.10    -26.62                                   
REMARK 500    LYS A 987      -61.49    146.06                                   
REMARK 500    SER A1009      156.58    152.71                                   
REMARK 500    PHE A1014       15.52    -67.54                                   
REMARK 500    THR A1026       -2.87    -59.80                                   
REMARK 500    LYS A1056       38.07     73.87                                   
REMARK 500    THR A1069       35.31    -95.44                                   
REMARK 500    ASN A1070       10.00   -155.31                                   
REMARK 500    ASN A1074       42.06     77.11                                   
REMARK 500    PRO A1077      151.71    -47.90                                   
REMARK 500    ALA A1079     -108.68   -135.44                                   
REMARK 500    SER A1081      -13.58     91.46                                   
REMARK 500    SER A1083      -38.64    -23.40                                   
REMARK 500    GLU A1103      -61.95    -24.14                                   
REMARK 500    ASN A1109       61.52   -152.04                                   
REMARK 500    THR A1125       46.11    100.87                                   
REMARK 500    TYR A1134      140.99   -171.56                                   
REMARK 500    ASN A1138       39.22     80.91                                   
REMARK 500    THR A1145      -17.70    159.76                                   
REMARK 500    ASN A1146       58.00     28.59                                   
REMARK 500    ASN A1174       61.74   -118.08                                   
REMARK 500    ASN A1188       97.67   -165.50                                   
REMARK 500    LEU A1209      -35.96   -131.40                                   
REMARK 500    PRO A1225       -9.40    -46.87                                   
REMARK 500    ASP A1247       76.20     53.62                                   
REMARK 500    CYS A1248       58.56   -168.70                                   
REMARK 500    ILE A1254      127.91    -14.97                                   
REMARK 500    TYR A1255       52.35     15.70                                   
REMARK 500    ALA A1256       13.98     82.08                                   
REMARK 500    ALA A1269      -60.45    -10.65                                   
REMARK 500    ARG A1280      -74.42    -39.44                                   
REMARK 500    ASN A1289      -94.36   -105.91                                   
REMARK 500    ASN A1290       91.03     56.98                                   
REMARK 500    VAL A1291      -93.39    -30.73                                   
REMARK 500    GLU A1293      136.72    -27.68                                   
REMARK 500    ARG A1296      100.98    -54.43                                   
REMARK 500    PRO A1303      -41.26    -26.32                                   
REMARK 500    CYS A1310       71.30   -100.32                                   
REMARK 500    ASP A1312     -179.07   -178.04                                   
REMARK 500    LYS A1313      -56.70    -27.14                                   
REMARK 500    VAL A1319     -111.93     10.40                                   
REMARK 500    ALA B   3        1.23    -28.71                                   
REMARK 500    ASP B   4     -143.62     17.62                                   
REMARK 500    ASN B  19       30.92   -145.72                                   
REMARK 500    ALA B  28      -55.16    125.16                                   
REMARK 500    ARG B  60      -58.56     85.45                                   
REMARK 500    ASN B  63       81.26     12.13                                   
REMARK 500    LEU B  74      -11.45   -146.04                                   
REMARK 500    HIS B  82       11.21     85.44                                   
REMARK 500    THR B  96      -80.13   -147.22                                   
REMARK 500    GLN B 112      -93.20   -104.31                                   
REMARK 500    TYR B 125      -39.44    -33.10                                   
REMARK 500    GLU B 133       84.54   -158.54                                   
REMARK 500    GLU B 140       -8.10    -53.50                                   
REMARK 500    ASN B 141      -11.17   -155.58                                   
REMARK 500    TYR B 153      -37.84     91.43                                   
REMARK 500    THR B 162      -31.32    -23.80                                   
REMARK 500    LEU B 204      113.67     95.14                                   
REMARK 500    LEU B 217      -36.83     89.29                                   
REMARK 500    LEU B 219     -101.39    -70.42                                   
REMARK 500    LYS B 220      -19.37     38.09                                   
REMARK 500    ASP B 221      -80.41   -103.86                                   
REMARK 500    THR B 222       85.66    -12.84                                   
REMARK 500    ARG B 233      -35.78   -149.14                                   
REMARK 500    THR B 262        2.07    -68.36                                   
REMARK 500    GLU B 263      -64.79   -122.29                                   
REMARK 500    LYS B 271       55.03   -105.39                                   
REMARK 500    ASN B 272       63.90    -21.93                                   
REMARK 500    PRO B 281     -119.29    -68.42                                   
REMARK 500    ALA B 282      -43.70     95.36                                   
REMARK 500    CYS B 303      134.47    -37.21                                   
REMARK 500    LYS B 318       41.28   -107.55                                   
REMARK 500    PRO B 320      105.95    -34.79                                   
REMARK 500    ALA B 321       36.92    -51.27                                   
REMARK 500    GLN B 322      -21.67   -142.42                                   
REMARK 500    THR B 324       36.80    -84.95                                   
REMARK 500    THR B 354        2.27    -61.30                                   
REMARK 500    ALA B 355       88.63    -59.13                                   
REMARK 500    ARG B 381      159.30    -36.47                                   
REMARK 500    HIS B 387      -17.78    -31.10                                   
REMARK 500    THR B 396     -160.34   -127.27                                   
REMARK 500    ALA B 424      -59.88   -144.64                                   
REMARK 500    SER B 425      114.25     78.70                                   
REMARK 500    ARG B 426       98.81     61.10                                   
REMARK 500    ASP B 429      105.57     37.54                                   
REMARK 500    ASP B 430     -179.24    176.73                                   
REMARK 500    ALA B 432       69.90   -116.59                                   
REMARK 500    LYS B 433      -65.73      0.37                                   
REMARK 500    GLU B 448      -68.43   -179.67                                   
REMARK 500    VAL B 449       79.73    117.30                                   
REMARK 500    ALA B 460     -145.37   -139.11                                   
REMARK 500    ALA B 466      -41.26    -25.15                                   
REMARK 500    GLN B 471      -89.79    -32.73                                   
REMARK 500    ARG B 472      -41.54    -20.22                                   
REMARK 500    LYS B 476     -147.28   -104.03                                   
REMARK 500    TRP B 478       92.98    -66.15                                   
REMARK 500    LEU B 494       48.66    -94.74                                   
REMARK 500    VAL B 523      -94.52    -60.11                                   
REMARK 500    LEU B 524      -79.71      5.52                                   
REMARK 500    GLN B 525      -19.48    -34.77                                   
REMARK 500    LYS B 526       48.57   -108.23                                   
REMARK 500    GLN B 529      -76.50    111.95                                   
REMARK 500    GLU B 530      117.10     71.70                                   
REMARK 500    LEU B 532      100.96    -24.74                                   
REMARK 500    ASP B 534      -85.75   -171.76                                   
REMARK 500    LYS B 538      113.91     94.01                                   
REMARK 500    LEU B 539       40.41   -102.22                                   
REMARK 500    ASP B 540     -111.32    -78.97                                   
REMARK 500    PRO B 541       81.73      0.17                                   
REMARK 500    THR B 542       84.85      1.60                                   
REMARK 500    SER B 545      -95.49    -29.50                                   
REMARK 500    PRO B 565      124.25     -7.02                                   
REMARK 500    HIS B 580      111.60    -29.49                                   
REMARK 500    LEU B 581      -19.82    -38.15                                   
REMARK 500    ALA B 591      115.95    -14.28                                   
REMARK 500    TYR B 593     -111.63    -96.11                                   
REMARK 500    CYS B 594      -66.03   -127.53                                   
REMARK 500    ASP B 595        4.75    -53.89                                   
REMARK 500    ILE B 597      123.02    -39.77                                   
REMARK 500    ARG B 607      127.50    159.49                                   
REMARK 500    HIS B 615      118.39   -171.61                                   
REMARK 500    SER B 620      168.09    173.78                                   
REMARK 500    SER B 644      113.55   -165.29                                   
REMARK 500    ASN B 651       21.72     46.11                                   
REMARK 500    ASP B 659      -35.22     72.97                                   
REMARK 500    HIS B 666      114.03     31.52                                   
REMARK 500    GLN B 680      -70.01    -29.45                                   
REMARK 500    ALA B 683      -33.92    -11.73                                   
REMARK 500    ASP B 701     -131.89     69.38                                   
REMARK 500    ALA B 702      -80.85     23.65                                   
REMARK 500    ASN B 706       85.19     52.41                                   
REMARK 500    SER B 707      -74.06    -78.37                                   
REMARK 500    GLU B 712      125.64    -36.14                                   
REMARK 500    ASP B 719      138.70    116.53                                   
REMARK 500    LEU B 720      -59.59    172.50                                   
REMARK 500    PHE B 724      -73.66     81.01                                   
REMARK 500    CYS B 749      136.85   -170.49                                   
REMARK 500    THR B 804      -35.07   -147.10                                   
REMARK 500    SER B 806      -51.49    -27.80                                   
REMARK 500    LEU B 835      -80.38    -81.84                                   
REMARK 500    SER B 866       94.14     12.68                                   
REMARK 500    ASP B 873     -166.74     50.49                                   
REMARK 500    LEU B 874      -13.94    -42.88                                   
REMARK 500    PHE B 884      -11.36    -39.78                                   
REMARK 500    ASN B 888     -108.09     50.73                                   
REMARK 500    ILE B 892       90.79   -166.18                                   
REMARK 500    MET B 921       44.95     80.76                                   
REMARK 500    LEU B 922      -60.43    141.98                                   
REMARK 500    ILE B 923      -83.40    -49.77                                   
REMARK 500    GLU B 925       36.51    123.66                                   
REMARK 500    CYS B 926      -82.77   -164.86                                   
REMARK 500    TRP B 927      -64.53     -0.68                                   
REMARK 500    VAL B 931      -77.50    -56.23                                   
REMARK 500    ALA B 932      -15.69    -41.01                                   
REMARK 500    MET B 937      -98.32    -79.83                                   
REMARK 500    PRO B 938      137.07    -36.76                                   
REMARK 500    TYR B 948      151.27    -32.28                                   
REMARK 500    THR B 954      162.65    -47.80                                   
REMARK 500    ALA B 974      -76.90    -81.14                                   
REMARK 500    GLN B 977       81.68     43.35                                   
REMARK 500    TYR B 978      -71.35    -71.60                                   
REMARK 500    ALA B 980      -67.55   -140.14                                   
REMARK 500    ARG B 981      -54.34     -5.90                                   
REMARK 500    LYS B 987      -59.99    132.34                                   
REMARK 500    THR B1004      148.14   -170.96                                   
REMARK 500    SER B1009      151.18    150.89                                   
REMARK 500    THR B1026        7.32    -61.39                                   
REMARK 500    VAL B1050      -70.99    -52.06                                   
REMARK 500    LYS B1056       25.70     84.25                                   
REMARK 500    ASN B1074       44.20     74.00                                   
REMARK 500    ALA B1079      -96.52   -143.83                                   
REMARK 500    SER B1081      -17.95     80.58                                   
REMARK 500    SER B1083      -36.05    -35.89                                   
REMARK 500    GLU B1103      -62.88    -18.83                                   
REMARK 500    LYS B1108       -4.89    -55.08                                   
REMARK 500    ASN B1109       66.03   -163.52                                   
REMARK 500    THR B1119      -19.57    -38.51                                   
REMARK 500    THR B1125       54.61    100.36                                   
REMARK 500    GLU B1144       66.11   -113.75                                   
REMARK 500    THR B1145      -17.75    155.63                                   
REMARK 500    ASN B1146       48.09     26.64                                   
REMARK 500    ASN B1174       75.13   -117.43                                   
REMARK 500    ASN B1188       89.17    178.15                                   
REMARK 500    LEU B1209      -31.11   -144.72                                   
REMARK 500    ASP B1247       75.84     42.87                                   
REMARK 500    CYS B1248       66.05   -163.93                                   
REMARK 500    ILE B1254      130.75    -24.71                                   
REMARK 500    TYR B1255       47.01     22.57                                   
REMARK 500    LEU B1267       -9.77    -51.57                                   
REMARK 500    ALA B1269      -51.47    -23.58                                   
REMARK 500    ASN B1289      -98.52   -108.79                                   
REMARK 500    ASN B1290       88.02     59.22                                   
REMARK 500    VAL B1291      -90.19    -34.33                                   
REMARK 500    PRO B1303      -40.98    -25.37                                   
REMARK 500    LYS B1327       14.61   -153.75                                   
REMARK 500    SER B1330     -120.15   -132.22                                   
REMARK 500    VAL B1331     -133.20    109.00                                   
REMARK 500    ASP C   4      -68.67   -127.28                                   
REMARK 500    ASN C  19       27.67   -147.52                                   
REMARK 500    PRO C  22      -16.49    -49.46                                   
REMARK 500    ALA C  28      -60.14    126.46                                   
REMARK 500    ARG C  60      -62.18     99.12                                   
REMARK 500    ASN C  63       67.33     39.50                                   
REMARK 500    THR C  96      -86.49   -144.82                                   
REMARK 500    GLN C 112      -97.28   -103.93                                   
REMARK 500    GLU C 133       80.74   -150.51                                   
REMARK 500    ASN C 141      -16.69   -160.45                                   
REMARK 500    TYR C 153      -28.61     80.58                                   
REMARK 500    THR C 162      -26.69    -34.74                                   
REMARK 500    PHE C 196      144.02   -170.59                                   
REMARK 500    PHE C 201      124.95    -34.50                                   
REMARK 500    LEU C 204      112.24     93.95                                   
REMARK 500    LEU C 217      -43.50     75.27                                   
REMARK 500    LEU C 219     -103.23    -84.30                                   
REMARK 500    LYS C 220      -12.57     41.84                                   
REMARK 500    ASP C 221      -73.66   -110.25                                   
REMARK 500    THR C 222       86.64    -21.11                                   
REMARK 500    GLU C 263      -77.29   -120.76                                   
REMARK 500    LYS C 271       51.24   -114.37                                   
REMARK 500    ASN C 272       54.44    -11.65                                   
REMARK 500    PRO C 281     -114.00    -83.81                                   
REMARK 500    ALA C 282      -43.69     79.47                                   
REMARK 500    THR C 311      -75.64    -70.85                                   
REMARK 500    PRO C 320      104.09    -26.41                                   
REMARK 500    ALA C 321       27.21    -53.84                                   
REMARK 500    THR C 324       34.10    -81.54                                   
REMARK 500    THR C 354       -4.12    -58.54                                   
REMARK 500    ARG C 380       51.19   -149.83                                   
REMARK 500    ARG C 381      157.99    -46.02                                   
REMARK 500    HIS C 387      -15.45    -46.50                                   
REMARK 500    TYR C 393      108.07    -57.00                                   
REMARK 500    LEU C 398      142.47    -37.47                                   
REMARK 500    ALA C 424     -111.04   -114.45                                   
REMARK 500    SER C 425       39.83   -165.90                                   
REMARK 500    ARG C 426      123.67    131.27                                   
REMARK 500    LYS C 433      -90.01     75.91                                   
REMARK 500    GLU C 448      -66.34   -162.55                                   
REMARK 500    VAL C 449       70.06    123.07                                   
REMARK 500    ALA C 460     -159.96   -135.31                                   
REMARK 500    ALA C 466      -39.69    -35.21                                   
REMARK 500    GLN C 471      -87.13    -35.96                                   
REMARK 500    ARG C 472      -43.97    -18.98                                   
REMARK 500    LYS C 476     -148.20   -106.21                                   
REMARK 500    LEU C 494       44.22   -106.65                                   
REMARK 500    ALA C 500      147.16    -38.77                                   
REMARK 500    THR C 512      -65.50    -22.89                                   
REMARK 500    GLN C 525      -39.71    -28.42                                   
REMARK 500    GLN C 529      -32.96     92.68                                   
REMARK 500    GLU C 530      161.34     -0.72                                   
REMARK 500    ASN C 531       89.53    140.72                                   
REMARK 500    ASP C 534      -43.95    145.29                                   
REMARK 500    LYS C 538      169.51     69.14                                   
REMARK 500    LEU C 539      -50.23   -143.83                                   
REMARK 500    THR C 542       60.45     71.99                                   
REMARK 500    PHE C 543     -141.81    -51.54                                   
REMARK 500    ALA C 544      137.13    116.61                                   
REMARK 500    SER C 545      -83.11   -125.78                                   
REMARK 500    ALA C 546     -160.38    151.31                                   
REMARK 500    PRO C 565      128.09     -9.31                                   
REMARK 500    HIS C 580      111.46    -37.32                                   
REMARK 500    LEU C 581      -15.58    -33.10                                   
REMARK 500    ALA C 591      102.95    -41.81                                   
REMARK 500    CYS C 594      -75.47   -173.35                                   
REMARK 500    ASP C 595       38.52    -62.12                                   
REMARK 500    ARG C 607      128.64    163.38                                   
REMARK 500    CYS C 634      151.09    177.34                                   
REMARK 500    ASN C 651       29.48     37.62                                   
REMARK 500    ASP C 659      -35.66     73.33                                   
REMARK 500    HIS C 666      119.05     26.79                                   
REMARK 500    ALA C 683      -26.01    -16.83                                   
REMARK 500    ASP C 701     -142.85     60.71                                   
REMARK 500    ALA C 702      -83.17     35.18                                   
REMARK 500    LYS C 704      -19.26    -34.48                                   
REMARK 500    ASN C 706       87.59     44.24                                   
REMARK 500    SER C 707      -78.13    -74.31                                   
REMARK 500    GLU C 712      125.80    -38.43                                   
REMARK 500    ASP C 719      136.46    132.27                                   
REMARK 500    LEU C 720      -57.43    173.33                                   
REMARK 500    PHE C 724      -64.87     87.57                                   
REMARK 500    PHE C 743       64.69     30.27                                   
REMARK 500    CYS C 749      134.85   -178.12                                   
REMARK 500    THR C 804      -32.86   -139.43                                   
REMARK 500    LEU C 835      -78.11    -65.24                                   
REMARK 500    SER C 866       95.76      8.66                                   
REMARK 500    ASP C 873     -158.32     52.32                                   
REMARK 500    LEU C 874       -1.75    -55.87                                   
REMARK 500    PHE C 884       -7.89    -51.51                                   
REMARK 500    ASN C 888     -104.35     55.96                                   
REMARK 500    ILE C 892       85.33   -162.56                                   
REMARK 500    ASN C 905       50.68   -102.97                                   
REMARK 500    MET C 921       54.57     78.14                                   
REMARK 500    LEU C 922      -53.70    135.26                                   
REMARK 500    ILE C 923      -81.88    -57.80                                   
REMARK 500    GLU C 925       37.49    126.09                                   
REMARK 500    CYS C 926      -89.65   -164.98                                   
REMARK 500    TRP C 927      -63.37      4.76                                   
REMARK 500    VAL C 931      -80.29    -51.72                                   
REMARK 500    ALA C 932      -22.36    -37.73                                   
REMARK 500    MET C 937      -99.03    -87.52                                   
REMARK 500    PRO C 938      131.79    -23.45                                   
REMARK 500    TYR C 948      149.43    -39.59                                   
REMARK 500    ASP C 952     -172.42    -61.73                                   
REMARK 500    HIS C 955       -8.93    -59.11                                   
REMARK 500    LEU C 973       -8.84    -58.69                                   
REMARK 500    ALA C 974      -75.36    -69.68                                   
REMARK 500    GLN C 977       77.15     50.93                                   
REMARK 500    TYR C 978      -71.73    -68.19                                   
REMARK 500    ALA C 980      -54.80   -136.97                                   
REMARK 500    ARG C 981      -53.96    -22.85                                   
REMARK 500    VAL C 985      -76.61    -65.56                                   
REMARK 500    LYS C 987      -64.57    140.02                                   
REMARK 500    THR C1004      138.30   -170.30                                   
REMARK 500    SER C1009      155.79    147.24                                   
REMARK 500    PHE C1014        0.72    -61.26                                   
REMARK 500    GLN C1049      -65.47    -26.98                                   
REMARK 500    LYS C1056       22.43     82.67                                   
REMARK 500    THR C1069       40.73   -103.37                                   
REMARK 500    ASN C1070        8.07   -161.46                                   
REMARK 500    VAL C1072       99.46   -163.63                                   
REMARK 500    ASN C1074       48.83     82.36                                   
REMARK 500    ALA C1079     -110.20   -128.69                                   
REMARK 500    SER C1081      -37.29     82.32                                   
REMARK 500    SER C1083      -41.83    -21.56                                   
REMARK 500    ASN C1109       64.73   -167.16                                   
REMARK 500    THR C1125       46.93    104.03                                   
REMARK 500    THR C1145      -23.21    152.12                                   
REMARK 500    ASN C1146       57.94     26.28                                   
REMARK 500    PHE C1151     -165.20   -111.42                                   
REMARK 500    VAL C1158      138.34   -170.59                                   
REMARK 500    ASN C1174       79.80   -110.68                                   
REMARK 500    ASN C1188       90.11   -177.06                                   
REMARK 500    LEU C1209      -46.03   -145.87                                   
REMARK 500    PRO C1225      -14.19    -47.89                                   
REMARK 500    ASP C1247       80.61     39.69                                   
REMARK 500    CYS C1248       71.39   -167.34                                   
REMARK 500    ILE C1254      126.89    -28.86                                   
REMARK 500    TYR C1255       40.46     32.71                                   
REMARK 500    LEU C1267      -17.31    -35.11                                   
REMARK 500    ALA C1269      -61.93     -5.77                                   
REMARK 500    ARG C1280      -85.61    -29.01                                   
REMARK 500    ALA C1281      -21.45    -36.43                                   
REMARK 500    HIS C1286       31.28    -95.28                                   
REMARK 500    ASN C1289      -95.50    -94.63                                   
REMARK 500    ASN C1290       91.97     54.69                                   
REMARK 500    VAL C1291      -93.87    -32.73                                   
REMARK 500    THR C1315      -35.76    -32.78                                   
REMARK 500    ASP D   4      -42.82   -133.94                                   
REMARK 500    ASN D  19       28.60   -148.22                                   
REMARK 500    ALA D  28      -57.88    112.18                                   
REMARK 500    ARG D  60      -36.74     90.78                                   
REMARK 500    ASN D  63       74.55     17.60                                   
REMARK 500    LEU D  80       -0.64    -59.16                                   
REMARK 500    THR D  96      -88.46   -132.59                                   
REMARK 500    GLN D 112      -98.90    -96.85                                   
REMARK 500    GLU D 140       -5.76    -58.70                                   
REMARK 500    ASN D 141      -15.23   -157.45                                   
REMARK 500    TYR D 153      -24.97     76.25                                   
REMARK 500    PHE D 196      130.43   -176.00                                   
REMARK 500    LEU D 204      109.79    101.49                                   
REMARK 500    LEU D 217      -32.38     86.61                                   
REMARK 500    LEU D 219      -97.11    -77.68                                   
REMARK 500    LYS D 220      -11.48     31.52                                   
REMARK 500    ASP D 221      -75.58   -109.79                                   
REMARK 500    THR D 222       84.07    -23.99                                   
REMARK 500    ARG D 233      -35.22   -138.64                                   
REMARK 500    HIS D 252       78.32   -155.64                                   
REMARK 500    GLU D 263      -73.75   -111.41                                   
REMARK 500    LYS D 271       51.28   -114.02                                   
REMARK 500    ASN D 272       51.77    -18.61                                   
REMARK 500    PRO D 281     -112.00    -80.15                                   
REMARK 500    ALA D 282      -21.73     82.82                                   
REMARK 500    LYS D 310      -35.14    -38.16                                   
REMARK 500    THR D 311      -76.74    -70.89                                   
REMARK 500    LEU D 312      -56.68    -26.75                                   
REMARK 500    LYS D 318       34.37    -99.98                                   
REMARK 500    PRO D 320      107.47    -32.75                                   
REMARK 500    ALA D 321       18.86    -57.96                                   
REMARK 500    PHE D 337       90.92    -68.16                                   
REMARK 500    ARG D 380       44.19   -151.55                                   
REMARK 500    ARG D 381      153.97    -38.05                                   
REMARK 500    THR D 396     -156.36   -131.32                                   
REMARK 500    ALA D 424      -77.53   -137.86                                   
REMARK 500    SER D 425       80.99    145.02                                   
REMARK 500    ARG D 426       89.35     81.74                                   
REMARK 500    ARG D 427      -82.72    -22.81                                   
REMARK 500    ASP D 429       90.71     47.63                                   
REMARK 500    ASP D 430     -158.23   -157.77                                   
REMARK 500    GLU D 448      -69.71   -167.77                                   
REMARK 500    VAL D 449       76.86    121.69                                   
REMARK 500    ALA D 460     -157.84   -135.79                                   
REMARK 500    ALA D 466      -33.41    -33.29                                   
REMARK 500    GLN D 471      -73.41    -40.02                                   
REMARK 500    ARG D 472      -36.31    -36.14                                   
REMARK 500    LYS D 476     -137.91   -100.74                                   
REMARK 500    LEU D 494       35.39    -88.42                                   
REMARK 500    THR D 510      -19.56    -47.56                                   
REMARK 500    THR D 512      -15.55    -40.03                                   
REMARK 500    VAL D 523      -70.40    -67.80                                   
REMARK 500    LEU D 524      -77.30    -15.18                                   
REMARK 500    GLN D 525      -19.21    -36.58                                   
REMARK 500    LYS D 526       54.72   -119.63                                   
REMARK 500    GLU D 530       43.55    100.20                                   
REMARK 500    ASN D 531       18.86    -51.61                                   
REMARK 500    LEU D 532      -58.01    -27.91                                   
REMARK 500    GLU D 533      -14.05   -148.64                                   
REMARK 500    ASP D 534     -104.98     -8.19                                   
REMARK 500    LYS D 535      -17.10   -162.48                                   
REMARK 500    LEU D 539     -153.89   -110.61                                   
REMARK 500    ASP D 540      -79.35   -104.25                                   
REMARK 500    PRO D 565      121.09    -11.13                                   
REMARK 500    HIS D 580      105.15    -29.80                                   
REMARK 500    LEU D 581      -29.65    -25.62                                   
REMARK 500    ALA D 591      103.24    -37.57                                   
REMARK 500    TYR D 593     -115.74   -110.81                                   
REMARK 500    ASP D 595       24.27    -53.23                                   
REMARK 500    PRO D 598      122.18    -23.12                                   
REMARK 500    ARG D 607      129.94    161.65                                   
REMARK 500    CYS D 634      144.67   -175.61                                   
REMARK 500    ASN D 651       15.36     48.06                                   
REMARK 500    ALA D 657      140.55    -39.98                                   
REMARK 500    ASP D 659      -40.19     68.15                                   
REMARK 500    HIS D 666      123.28     27.34                                   
REMARK 500    ALA D 673     -166.96   -128.60                                   
REMARK 500    ALA D 683      -39.95    -10.71                                   
REMARK 500    ILE D 697      -70.55   -116.27                                   
REMARK 500    ASP D 701     -125.15     59.93                                   
REMARK 500    ALA D 702      -73.08     21.62                                   
REMARK 500    ASN D 706       80.83     38.97                                   
REMARK 500    SER D 707     -144.17    -66.61                                   
REMARK 500    PHE D 708       80.13     91.94                                   
REMARK 500    GLU D 712      116.70    -37.92                                   
REMARK 500    ASP D 719      141.49    136.79                                   
REMARK 500    LEU D 720      -46.09    176.91                                   
REMARK 500    PHE D 724      -65.99     77.85                                   
REMARK 500    PHE D 743       55.52     39.53                                   
REMARK 500    CYS D 749      136.98    179.37                                   
REMARK 500    PRO D 784      150.73    -48.36                                   
REMARK 500    THR D 804      -44.92   -136.07                                   
REMARK 500    SER D 806      -49.14    -27.14                                   
REMARK 500    LEU D 835      -71.63    -65.81                                   
REMARK 500    SER D 866       92.42   -161.47                                   
REMARK 500    ASN D 870       30.55    -99.62                                   
REMARK 500    THR D 871      146.02   -173.62                                   
REMARK 500    ASP D 873     -155.18     60.11                                   
REMARK 500    LEU D 874       -8.87    -48.32                                   
REMARK 500    PHE D 884      -15.16    -40.80                                   
REMARK 500    ASN D 888     -105.26     50.43                                   
REMARK 500    ILE D 892       81.16   -172.61                                   
REMARK 500    ASN D 905       50.26    -91.23                                   
REMARK 500    MET D 921       48.63     83.46                                   
REMARK 500    LEU D 922      -51.99    149.07                                   
REMARK 500    ILE D 923      -88.55    -51.54                                   
REMARK 500    GLU D 925       27.70    118.47                                   
REMARK 500    CYS D 926      -84.43   -151.99                                   
REMARK 500    TRP D 927      -61.97     -0.81                                   
REMARK 500    MET D 937     -101.44    -83.08                                   
REMARK 500    PRO D 938      143.77    -37.62                                   
REMARK 500    TYR D 948      151.99    -30.30                                   
REMARK 500    THR D 954      157.01    -36.80                                   
REMARK 500    HIS D 955        3.57    -62.59                                   
REMARK 500    ALA D 974      -73.03    -77.42                                   
REMARK 500    SER D 976      -32.25    -39.12                                   
REMARK 500    GLN D 977       78.17     38.04                                   
REMARK 500    ALA D 980      -51.87   -132.60                                   
REMARK 500    ARG D 981      -56.58    -18.70                                   
REMARK 500    VAL D 985      -75.47    -75.79                                   
REMARK 500    LYS D 987      -66.07    144.28                                   
REMARK 500    SER D1009      159.10    156.84                                   
REMARK 500    PHE D1014        0.46    -69.19                                   
REMARK 500    VAL D1050      -71.21    -55.17                                   
REMARK 500    THR D1069       45.53    -99.95                                   
REMARK 500    ASN D1070        7.70   -166.96                                   
REMARK 500    ASN D1074       53.08     79.29                                   
REMARK 500    PRO D1077      151.17    -46.19                                   
REMARK 500    ALA D1079     -105.89   -131.97                                   
REMARK 500    ALA D1080       41.37    -76.28                                   
REMARK 500    SER D1081      -16.67     86.72                                   
REMARK 500    SER D1083      -37.56    -26.54                                   
REMARK 500    GLU D1103      -66.50    -20.89                                   
REMARK 500    ASN D1109       51.79   -152.03                                   
REMARK 500    PRO D1110        7.25    -69.80                                   
REMARK 500    THR D1125       57.37    101.73                                   
REMARK 500    TYR D1134      144.09   -171.70                                   
REMARK 500    ASN D1138       41.43     73.01                                   
REMARK 500    THR D1145      -25.27    145.14                                   
REMARK 500    ASN D1146       53.31     30.11                                   
REMARK 500    ASN D1174       67.59   -116.31                                   
REMARK 500    ASN D1188       91.77   -179.04                                   
REMARK 500    THR D1208       -6.75   -141.91                                   
REMARK 500    LEU D1209      -25.34   -146.65                                   
REMARK 500    PRO D1225      -17.42    -40.92                                   
REMARK 500    ASP D1247       79.38     37.70                                   
REMARK 500    CYS D1248       58.56   -163.23                                   
REMARK 500    ILE D1254      132.79    -23.57                                   
REMARK 500    TYR D1255       39.46     22.65                                   
REMARK 500    LEU D1267      -14.47    -45.95                                   
REMARK 500    ALA D1269      -54.96    -11.19                                   
REMARK 500    ASN D1289      -99.09   -100.04                                   
REMARK 500    ASN D1290       86.49     59.68                                   
REMARK 500    VAL D1291      -85.70    -34.81                                   
REMARK 500    GLU D1293      151.87    -45.76                                   
REMARK 500    PRO D1303      -57.42    -28.56                                   
REMARK 500    LYS D1313      -50.88    -23.25                                   
REMARK 500    THR D1316      -65.42    -28.88                                   
REMARK 500    CYS D1318     -109.40    -88.48                                   
REMARK 500    LYS D1327     -107.50    159.16                                   
REMARK 500    PRO D1328     -102.23    -91.16                                   
REMARK 500    TRP D1329      -13.31   -145.42                                   
REMARK 500    VAL D1331      -75.96   -151.83                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 GLU A  140     ASN A  141                 -119.95                    
REMARK 500 ALA A  164     ARG A  165                  142.64                    
REMARK 500 THR A  202     PRO A  203                 -144.25                    
REMARK 500 THR A  222     PRO A  223                 -149.12                    
REMARK 500 PRO A  294     ASP A  295                 -136.26                    
REMARK 500 PHE A  337     ALA A  338                  134.50                    
REMARK 500 GLY A  339     LYS A  340                 -148.69                    
REMARK 500 THR A  354     ALA A  355                 -108.93                    
REMARK 500 GLN A  423     ALA A  424                 -141.19                    
REMARK 500 ASP A  430     ILE A  431                 -132.62                    
REMARK 500 THR A  446     THR A  447                  148.61                    
REMARK 500 ALA A  460     ASN A  461                  149.00                    
REMARK 500 ALA A  466     LEU A  467                 -105.33                    
REMARK 500 MET A  504     VAL A  505                 -144.56                    
REMARK 500 LEU A  527     GLY A  528                  144.13                    
REMARK 500 GLY A  528     GLN A  529                 -120.04                    
REMARK 500 GLN A  529     GLU A  530                 -141.16                    
REMARK 500 ASN A  531     LEU A  532                  144.01                    
REMARK 500 VAL A  664     GLY A  665                  127.08                    
REMARK 500 GLY A  665     HIS A  666                   94.90                    
REMARK 500 GLN A  684     GLY A  685                  120.27                    
REMARK 500 GLU A  700     ASP A  701                 -147.04                    
REMARK 500 SER A  707     PHE A  708                  -99.75                    
REMARK 500 GLY A  718     ASP A  719                 -127.41                    
REMARK 500 ASP A  719     LEU A  720                  -96.11                    
REMARK 500 VAL A  731     SER A  732                 -131.39                    
REMARK 500 GLY A  838     GLY A  839                 -146.67                    
REMARK 500 PHE A  865     SER A  866                  111.92                    
REMARK 500 LYS A  891     ILE A  892                 -148.32                    
REMARK 500 ILE A  892     PRO A  893                 -145.84                    
REMARK 500 GLN A  919     GLY A  920                 -148.48                    
REMARK 500 GLY A  920     MET A  921                   85.64                    
REMARK 500 CYS A  926     TRP A  927                  111.76                    
REMARK 500 GLY A  936     MET A  937                 -123.94                    
REMARK 500 MET A  937     PRO A  938                  -79.73                    
REMARK 500 HIS A  979     ALA A  980                   90.08                    
REMARK 500 SER A 1299     PRO A 1300                   58.65                    
REMARK 500 CYS A 1318     VAL A 1319                  131.33                    
REMARK 500 VAL A 1319     THR A 1320                  127.79                    
REMARK 500 ALA B    3     ASP B    4                  134.66                    
REMARK 500 GLY B   38     THR B   39                  145.76                    
REMARK 500 GLU B  140     ASN B  141                 -122.18                    
REMARK 500 ALA B  164     ARG B  165                  145.44                    
REMARK 500 THR B  202     PRO B  203                 -144.58                    
REMARK 500 ASP B  221     THR B  222                  146.33                    
REMARK 500 THR B  222     PRO B  223                 -148.59                    
REMARK 500 LYS B  271     ASN B  272                 -147.37                    
REMARK 500 PRO B  294     ASP B  295                 -134.94                    
REMARK 500 PHE B  337     ALA B  338                  129.47                    
REMARK 500 GLY B  339     LYS B  340                 -137.35                    
REMARK 500 THR B  354     ALA B  355                 -108.78                    
REMARK 500 GLN B  423     ALA B  424                 -145.57                    
REMARK 500 ALA B  424     SER B  425                 -145.17                    
REMARK 500 ASP B  430     ILE B  431                 -149.92                    
REMARK 500 ILE B  431     ALA B  432                 -128.23                    
REMARK 500 LYS B  443     PRO B  444                 -142.52                    
REMARK 500 THR B  446     THR B  447                  143.07                    
REMARK 500 ALA B  466     LEU B  467                 -103.32                    
REMARK 500 VAL B  523     LEU B  524                  148.31                    
REMARK 500 GLY B  528     GLN B  529                   94.76                    
REMARK 500 GLU B  530     ASN B  531                 -122.62                    
REMARK 500 ASN B  531     LEU B  532                  135.10                    
REMARK 500 LEU B  532     GLU B  533                   99.84                    
REMARK 500 ASP B  534     LYS B  535                 -126.78                    
REMARK 500 CYS B  536     GLY B  537                 -118.86                    
REMARK 500 ASP B  540     PRO B  541                 -133.42                    
REMARK 500 PRO B  541     THR B  542                  104.57                    
REMARK 500 THR B  542     PHE B  543                 -144.95                    
REMARK 500 ALA B  544     SER B  545                 -149.13                    
REMARK 500 GLU B  590     ALA B  591                  148.23                    
REMARK 500 THR B  623     SER B  624                 -149.31                    
REMARK 500 VAL B  664     GLY B  665                  111.57                    
REMARK 500 GLY B  665     HIS B  666                   97.04                    
REMARK 500 ALA B  683     GLN B  684                 -146.16                    
REMARK 500 GLN B  684     GLY B  685                  106.52                    
REMARK 500 SER B  707     PHE B  708                 -104.06                    
REMARK 500 PHE B  708     TYR B  709                  149.04                    
REMARK 500 GLY B  718     ASP B  719                 -126.45                    
REMARK 500 ASP B  719     LEU B  720                  -91.69                    
REMARK 500 VAL B  731     SER B  732                 -128.29                    
REMARK 500 PHE B  865     SER B  866                  100.25                    
REMARK 500 ILE B  892     PRO B  893                 -145.84                    
REMARK 500 GLY B  920     MET B  921                  -87.08                    
REMARK 500 CYS B  926     TRP B  927                  115.73                    
REMARK 500 GLY B  936     MET B  937                 -114.94                    
REMARK 500 MET B  937     PRO B  938                  -75.53                    
REMARK 500 HIS B  979     ALA B  980                   99.24                    
REMARK 500 SER B 1299     PRO B 1300                   59.63                    
REMARK 500 LYS B 1327     PRO B 1328                 -110.30                    
REMARK 500 VAL B 1331     ARG B 1332                 -145.45                    
REMARK 500 GLU C  140     ASN C  141                 -115.95                    
REMARK 500 CYS C  150     THR C  151                 -149.98                    
REMARK 500 PRO C  193     SER C  194                 -146.11                    
REMARK 500 THR C  202     PRO C  203                 -143.64                    
REMARK 500 THR C  222     PRO C  223                 -149.98                    
REMARK 500 PRO C  294     ASP C  295                 -140.90                    
REMARK 500 PHE C  337     ALA C  338                  127.56                    
REMARK 500 THR C  354     ALA C  355                  -94.05                    
REMARK 500 ALA C  424     SER C  425                 -142.46                    
REMARK 500 LYS C  443     PRO C  444                 -144.59                    
REMARK 500 THR C  446     THR C  447                  143.17                    
REMARK 500 ALA C  466     LEU C  467                 -104.59                    
REMARK 500 MET C  504     VAL C  505                 -148.19                    
REMARK 500 GLY C  528     GLN C  529                  109.65                    
REMARK 500 GLU C  530     ASN C  531                 -139.78                    
REMARK 500 LEU C  532     GLU C  533                 -107.24                    
REMARK 500 GLU C  533     ASP C  534                  -96.08                    
REMARK 500 ASP C  534     LYS C  535                 -135.91                    
REMARK 500 LYS C  535     CYS C  536                  145.26                    
REMARK 500 CYS C  536     GLY C  537                  145.04                    
REMARK 500 LYS C  538     LEU C  539                 -142.12                    
REMARK 500 ASP C  540     PRO C  541                 -132.29                    
REMARK 500 ALA C  546     THR C  547                  135.17                    
REMARK 500 GLY C  567     GLN C  568                 -149.14                    
REMARK 500 VAL C  664     GLY C  665                  121.91                    
REMARK 500 GLY C  665     HIS C  666                   93.40                    
REMARK 500 ALA C  683     GLN C  684                 -149.44                    
REMARK 500 GLN C  684     GLY C  685                  111.48                    
REMARK 500 GLU C  700     ASP C  701                 -147.56                    
REMARK 500 SER C  707     PHE C  708                 -106.78                    
REMARK 500 PHE C  708     TYR C  709                  148.86                    
REMARK 500 GLY C  718     ASP C  719                 -132.24                    
REMARK 500 ASP C  719     LEU C  720                  -94.94                    
REMARK 500 VAL C  731     SER C  732                 -133.01                    
REMARK 500 PHE C  865     SER C  866                  101.77                    
REMARK 500 LYS C  891     ILE C  892                 -145.44                    
REMARK 500 ILE C  892     PRO C  893                 -141.10                    
REMARK 500 GLY C  920     MET C  921                  -90.14                    
REMARK 500 CYS C  926     TRP C  927                  114.29                    
REMARK 500 GLY C  936     MET C  937                 -113.58                    
REMARK 500 MET C  937     PRO C  938                  -80.64                    
REMARK 500 HIS C  979     ALA C  980                   97.18                    
REMARK 500 ALA C 1079     ALA C 1080                 -141.37                    
REMARK 500 GLU C 1144     THR C 1145                 -147.52                    
REMARK 500 ALA C 1268     ALA C 1269                  146.33                    
REMARK 500 SER C 1299     PRO C 1300                   60.66                    
REMARK 500 GLN D  131     PRO D  132                 -146.17                    
REMARK 500 GLU D  140     ASN D  141                 -122.83                    
REMARK 500 ALA D  164     ARG D  165                  145.74                    
REMARK 500 PRO D  193     SER D  194                 -144.92                    
REMARK 500 THR D  202     PRO D  203                 -148.33                    
REMARK 500 THR D  222     PRO D  223                 -145.52                    
REMARK 500 LYS D  271     ASN D  272                 -148.58                    
REMARK 500 PRO D  281     ALA D  282                  141.43                    
REMARK 500 PRO D  294     ASP D  295                 -136.85                    
REMARK 500 PHE D  337     ALA D  338                  133.46                    
REMARK 500 GLY D  339     LYS D  340                 -139.37                    
REMARK 500 THR D  354     ALA D  355                  -97.86                    
REMARK 500 ASP D  429     ASP D  430                  140.47                    
REMARK 500 ILE D  431     ALA D  432                 -114.24                    
REMARK 500 LYS D  443     PRO D  444                 -147.19                    
REMARK 500 THR D  446     THR D  447                  148.45                    
REMARK 500 ALA D  466     LEU D  467                 -112.78                    
REMARK 500 LEU D  527     GLY D  528                  146.81                    
REMARK 500 GLY D  528     GLN D  529                 -147.37                    
REMARK 500 GLU D  530     ASN D  531                  148.55                    
REMARK 500 LEU D  532     GLU D  533                  109.01                    
REMARK 500 GLU D  533     ASP D  534                 -102.85                    
REMARK 500 LYS D  535     CYS D  536                 -117.76                    
REMARK 500 CYS D  536     GLY D  537                  144.96                    
REMARK 500 LYS D  538     LEU D  539                  116.87                    
REMARK 500 ASP D  540     PRO D  541                  133.58                    
REMARK 500 ILE D  649     CYS D  650                  144.49                    
REMARK 500 VAL D  664     GLY D  665                  119.71                    
REMARK 500 GLY D  665     HIS D  666                   88.50                    
REMARK 500 GLN D  684     GLY D  685                  105.89                    
REMARK 500 ILE D  699     GLU D  700                  148.31                    
REMARK 500 GLU D  700     ASP D  701                 -141.20                    
REMARK 500 SER D  707     PHE D  708                  115.33                    
REMARK 500 GLY D  718     ASP D  719                 -141.17                    
REMARK 500 ASP D  719     LEU D  720                  -98.15                    
REMARK 500 VAL D  731     SER D  732                 -129.50                    
REMARK 500 PHE D  865     SER D  866                 -120.74                    
REMARK 500 LYS D  891     ILE D  892                 -144.87                    
REMARK 500 ILE D  892     PRO D  893                 -135.75                    
REMARK 500 GLN D  919     GLY D  920                 -149.50                    
REMARK 500 GLY D  920     MET D  921                 -100.18                    
REMARK 500 CYS D  926     TRP D  927                  114.48                    
REMARK 500 GLY D  936     MET D  937                 -117.22                    
REMARK 500 MET D  937     PRO D  938                  -82.24                    
REMARK 500 HIS D  979     ALA D  980                   89.11                    
REMARK 500 ALA D 1079     ALA D 1080                 -147.46                    
REMARK 500 GLU D 1144     THR D 1145                 -149.16                    
REMARK 500 SER D 1299     PRO D 1300                   56.99                    
REMARK 500 LYS D 1327     PRO D 1328                  -99.83                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION, C(I) - CA(I) - N(I+1) - O(I), GREATER                       
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    PHE A 865         10.02                                           
REMARK 500    GLY B 528         10.17                                           
REMARK 500    PHE B 865         11.12                                           
REMARK 500    GLY B 920        -14.43                                           
REMARK 500    SER C 707        -11.06                                           
REMARK 500    GLY C 920        -14.63                                           
REMARK 500    HIS C 979         10.05                                           
REMARK 500    GLY D 665         12.13                                           
REMARK 500    GLN D 684         11.34                                           
REMARK 500    SER D 707         10.19                                           
REMARK 500    PHE D 865        -12.20                                           
REMARK 500    GLY D 920        -11.04                                           
REMARK 500    HIS D 979         10.90                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CHIRAL CENTERS                                             
REMARK 500                                                                      
REMARK 500 UNEXPECTED CONFIGURATION OF THE FOLLOWING CHIRAL                     
REMARK 500 CENTER(S) USING IMPROPER CA--C--CB--N CHIRALITY                      
REMARK 500 M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN                            
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE                   
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,6X,F5.1,6X,A1,10X,A1,3X,A16)       
REMARK 500                                                                      
REMARK 500  M RES CSSEQI    IMPROPER   EXPECTED   FOUND DETAILS                 
REMARK 500    ILE A  77        24.9      L          L   OUTSIDE RANGE           
REMARK 500    THR A  96        24.9      L          L   OUTSIDE RANGE           
REMARK 500    THR A 117        23.9      L          L   OUTSIDE RANGE           
REMARK 500    ARG A 165        13.5      L          L   OUTSIDE RANGE           
REMARK 500    SER A 194        21.9      L          L   OUTSIDE RANGE           
REMARK 500    LEU A 216        46.2      L          L   OUTSIDE RANGE           
REMARK 500    ILE A 307        22.4      L          L   OUTSIDE RANGE           
REMARK 500    LYS A 318        23.7      L          L   OUTSIDE RANGE           
REMARK 500    LYS A 340        23.9      L          L   OUTSIDE RANGE           
REMARK 500    VAL A 345        12.4      L          L   OUTSIDE RANGE           
REMARK 500    ILE A 358        24.0      L          L   OUTSIDE RANGE           
REMARK 500    THR A 382        24.6      L          L   OUTSIDE RANGE           
REMARK 500    GLN A 423        23.2      L          L   OUTSIDE RANGE           
REMARK 500    SER A 425        23.5      L          L   OUTSIDE RANGE           
REMARK 500    ALA A 432        24.6      L          L   OUTSIDE RANGE           
REMARK 500    ILE A 464        22.0      L          L   OUTSIDE RANGE           
REMARK 500    LEU A 467        21.6      L          L   OUTSIDE RANGE           
REMARK 500    SER A 475        21.2      L          L   OUTSIDE RANGE           
REMARK 500    ASP A 499        24.9      L          L   OUTSIDE RANGE           
REMARK 500    VAL A 505        19.4      L          L   OUTSIDE RANGE           
REMARK 500    GLU A 530        17.9      L          L   OUTSIDE RANGE           
REMARK 500    GLU A 533        22.6      L          L   OUTSIDE RANGE           
REMARK 500    GLN A 568        22.2      L          L   OUTSIDE RANGE           
REMARK 500    CYS A 594        19.6      L          L   OUTSIDE RANGE           
REMARK 500    THR A 610        23.7      L          L   OUTSIDE RANGE           
REMARK 500    VAL A 633        22.3      L          L   OUTSIDE RANGE           
REMARK 500    TYR A 709        24.5      L          L   OUTSIDE RANGE           
REMARK 500    VAL A 731        19.1      L          L   OUTSIDE RANGE           
REMARK 500    LEU A 745        23.6      L          L   OUTSIDE RANGE           
REMARK 500    THR A 767        24.5      L          L   OUTSIDE RANGE           
REMARK 500    THR A 770        24.8      L          L   OUTSIDE RANGE           
REMARK 500    LYS A 802        23.0      L          L   OUTSIDE RANGE           
REMARK 500    VAL A 808        24.1      L          L   OUTSIDE RANGE           
REMARK 500    THR A 837        24.1      L          L   OUTSIDE RANGE           
REMARK 500    VAL A 857        24.4      L          L   OUTSIDE RANGE           
REMARK 500    HIS A 885        24.7      L          L   OUTSIDE RANGE           
REMARK 500    MET A 937        24.5      L          L   OUTSIDE RANGE           
REMARK 500    ASN A 946        23.1      L          L   OUTSIDE RANGE           
REMARK 500    LEU A 953        21.8      L          L   OUTSIDE RANGE           
REMARK 500    ALA A 980        47.8      L          L   OUTSIDE RANGE           
REMARK 500    ARG A 981        24.8      L          L   OUTSIDE RANGE           
REMARK 500    ALA A1018        22.4      L          L   OUTSIDE RANGE           
REMARK 500    LEU A1031        22.5      L          L   OUTSIDE RANGE           
REMARK 500    SER A1065        24.7      L          L   OUTSIDE RANGE           
REMARK 500    ALA A1080        21.8      L          L   OUTSIDE RANGE           
REMARK 500    ILE A1098        23.8      L          L   OUTSIDE RANGE           
REMARK 500    THR A1169        24.8      L          L   OUTSIDE RANGE           
REMARK 500    ARG A1223        23.5      L          L   OUTSIDE RANGE           
REMARK 500    ILE A1254        22.6      L          L   OUTSIDE RANGE           
REMARK 500    ASN A1289        22.9      L          L   OUTSIDE RANGE           
REMARK 500    VAL A1291        24.5      L          L   OUTSIDE RANGE           
REMARK 500    LEU A1297        24.3      L          L   OUTSIDE RANGE           
REMARK 500    CYS A1318        21.1      L          L   OUTSIDE RANGE           
REMARK 500    VAL A1319        23.6      L          L   OUTSIDE RANGE           
REMARK 500    ALA B   3        13.4      L          L   OUTSIDE RANGE           
REMARK 500    ILE B  77        24.3      L          L   OUTSIDE RANGE           
REMARK 500    THR B 117        24.0      L          L   OUTSIDE RANGE           
REMARK 500    ARG B 165         3.3      L          D   EXPECTING SP3           
REMARK 500    SER B 194        21.2      L          L   OUTSIDE RANGE           
REMARK 500    LYS B 220        24.4      L          L   OUTSIDE RANGE           
REMARK 500    ILE B 307        23.9      L          L   OUTSIDE RANGE           
REMARK 500    LYS B 340        24.1      L          L   OUTSIDE RANGE           
REMARK 500    VAL B 345        17.9      L          L   OUTSIDE RANGE           
REMARK 500    ALA B 355        23.5      L          L   OUTSIDE RANGE           
REMARK 500    VAL B 375        24.8      L          L   OUTSIDE RANGE           
REMARK 500    THR B 382        21.2      L          L   OUTSIDE RANGE           
REMARK 500    SER B 425        24.7      L          L   OUTSIDE RANGE           
REMARK 500    ASP B 430        19.5      L          L   OUTSIDE RANGE           
REMARK 500    ILE B 431         9.1      L          D   EXPECTING SP3           
REMARK 500    ILE B 464        20.8      L          L   OUTSIDE RANGE           
REMARK 500    LEU B 467        24.4      L          L   OUTSIDE RANGE           
REMARK 500    SER B 475        20.3      L          L   OUTSIDE RANGE           
REMARK 500    GLN B 529        17.2      L          L   OUTSIDE RANGE           
REMARK 500    GLU B 530        13.6      L          L   OUTSIDE RANGE           
REMARK 500    GLU B 533        17.6      L          L   OUTSIDE RANGE           
REMARK 500    LYS B 535        21.4      L          L   OUTSIDE RANGE           
REMARK 500    PRO B 541        17.6      L          L   OUTSIDE RANGE           
REMARK 500    SER B 545        19.0      L          L   OUTSIDE RANGE           
REMARK 500    ALA B 546        22.8      L          L   OUTSIDE RANGE           
REMARK 500    ASP B 557        19.8      L          L   OUTSIDE RANGE           
REMARK 500    GLU B 590        22.1      L          L   OUTSIDE RANGE           
REMARK 500    ASP B 622        22.5      L          L   OUTSIDE RANGE           
REMARK 500    GLU B 653        23.7      L          L   OUTSIDE RANGE           
REMARK 500    TYR B 709        22.8      L          L   OUTSIDE RANGE           
REMARK 500    VAL B 731        21.4      L          L   OUTSIDE RANGE           
REMARK 500    VAL B 753        22.3      L          L   OUTSIDE RANGE           
REMARK 500    ASN B 769        24.4      L          L   OUTSIDE RANGE           
REMARK 500    THR B 770        24.4      L          L   OUTSIDE RANGE           
REMARK 500    LYS B 802        23.7      L          L   OUTSIDE RANGE           
REMARK 500    VAL B 808        24.3      L          L   OUTSIDE RANGE           
REMARK 500    THR B 811        24.6      L          L   OUTSIDE RANGE           
REMARK 500    MET B 937        22.8      L          L   OUTSIDE RANGE           
REMARK 500    ASN B 946        22.3      L          L   OUTSIDE RANGE           
REMARK 500    LEU B 953        23.9      L          L   OUTSIDE RANGE           
REMARK 500    ARG B 967        23.8      L          L   OUTSIDE RANGE           
REMARK 500    ALA B 980        47.1      L          L   OUTSIDE RANGE           
REMARK 500    ARG B 981        24.4      L          L   OUTSIDE RANGE           
REMARK 500    THR B1011        21.1      L          L   OUTSIDE RANGE           
REMARK 500    ALA B1018        19.5      L          L   OUTSIDE RANGE           
REMARK 500    THR B1026        24.6      L          L   OUTSIDE RANGE           
REMARK 500    LEU B1031        24.3      L          L   OUTSIDE RANGE           
REMARK 500    ALA B1080        22.4      L          L   OUTSIDE RANGE           
REMARK 500    ILE B1098        23.8      L          L   OUTSIDE RANGE           
REMARK 500    THR B1119        24.6      L          L   OUTSIDE RANGE           
REMARK 500    LEU B1175        24.0      L          L   OUTSIDE RANGE           
REMARK 500    ARG B1223        24.3      L          L   OUTSIDE RANGE           
REMARK 500    ILE B1254        22.7      L          L   OUTSIDE RANGE           
REMARK 500    ASN B1289        22.7      L          L   OUTSIDE RANGE           
REMARK 500    ASN B1290        24.6      L          L   OUTSIDE RANGE           
REMARK 500    VAL B1291        24.4      L          L   OUTSIDE RANGE           
REMARK 500    SER B1299        24.8      L          L   OUTSIDE RANGE           
REMARK 500    ASP B1312        23.9      L          L   OUTSIDE RANGE           
REMARK 500    VAL B1319        18.9      L          L   OUTSIDE RANGE           
REMARK 500    TRP B1329        21.1      L          L   OUTSIDE RANGE           
REMARK 500    SER B1330        23.3      L          L   OUTSIDE RANGE           
REMARK 500    VAL B1331        17.4      L          L   OUTSIDE RANGE           
REMARK 500    ARG C  32        23.0      L          L   OUTSIDE RANGE           
REMARK 500    LEU C  41        21.0      L          L   OUTSIDE RANGE           
REMARK 500    ASP C  59        23.9      L          L   OUTSIDE RANGE           
REMARK 500    ASN C  71        24.5      L          L   OUTSIDE RANGE           
REMARK 500    ARG C 165         7.5      L          D   EXPECTING SP3           
REMARK 500    SER C 194        22.8      L          L   OUTSIDE RANGE           
REMARK 500    LEU C 195        23.3      L          L   OUTSIDE RANGE           
REMARK 500    THR C 202        23.8      L          L   OUTSIDE RANGE           
REMARK 500    ILE C 307        23.3      L          L   OUTSIDE RANGE           
REMARK 500    ASP C 314        24.1      L          L   OUTSIDE RANGE           
REMARK 500    VAL C 316        24.3      L          L   OUTSIDE RANGE           
REMARK 500    VAL C 345        17.4      L          L   OUTSIDE RANGE           
REMARK 500    THR C 382        24.5      L          L   OUTSIDE RANGE           
REMARK 500    GLU C 401        23.5      L          L   OUTSIDE RANGE           
REMARK 500    ILE C 464        23.2      L          L   OUTSIDE RANGE           
REMARK 500    LEU C 467        22.2      L          L   OUTSIDE RANGE           
REMARK 500    THR C 470        24.2      L          L   OUTSIDE RANGE           
REMARK 500    SER C 475        22.0      L          L   OUTSIDE RANGE           
REMARK 500    GLN C 529        23.6      L          L   OUTSIDE RANGE           
REMARK 500    GLU C 530        18.3      L          L   OUTSIDE RANGE           
REMARK 500    GLU C 533        16.3      L          L   OUTSIDE RANGE           
REMARK 500    LYS C 535        22.9      L          L   OUTSIDE RANGE           
REMARK 500    LYS C 538        22.7      L          L   OUTSIDE RANGE           
REMARK 500    THR C 547        23.5      L          L   OUTSIDE RANGE           
REMARK 500    LEU C 560        24.1      L          L   OUTSIDE RANGE           
REMARK 500    CYS C 594        23.7      L          L   OUTSIDE RANGE           
REMARK 500    SER C 611        24.6      L          L   OUTSIDE RANGE           
REMARK 500    ASP C 622        25.0      L          L   OUTSIDE RANGE           
REMARK 500    VAL C 633        23.3      L          L   OUTSIDE RANGE           
REMARK 500    GLU C 653        18.2      L          L   OUTSIDE RANGE           
REMARK 500    TYR C 709        25.0      L          L   OUTSIDE RANGE           
REMARK 500    VAL C 730        24.8      L          L   OUTSIDE RANGE           
REMARK 500    VAL C 731        22.1      L          L   OUTSIDE RANGE           
REMARK 500    LEU C 745        21.4      L          L   OUTSIDE RANGE           
REMARK 500    VAL C 753        22.4      L          L   OUTSIDE RANGE           
REMARK 500    THR C 767        24.3      L          L   OUTSIDE RANGE           
REMARK 500    LYS C 802        24.2      L          L   OUTSIDE RANGE           
REMARK 500    THR C 837        22.6      L          L   OUTSIDE RANGE           
REMARK 500    SER C 866        22.4      L          L   OUTSIDE RANGE           
REMARK 500    GLN C 919        24.0      L          L   OUTSIDE RANGE           
REMARK 500    MET C 937        24.4      L          L   OUTSIDE RANGE           
REMARK 500    ARG C 981        22.3      L          L   OUTSIDE RANGE           
REMARK 500    THR C1011        24.5      L          L   OUTSIDE RANGE           
REMARK 500    PHE C1014        24.9      L          L   OUTSIDE RANGE           
REMARK 500    LEU C1031        22.9      L          L   OUTSIDE RANGE           
REMARK 500    SER C1068        24.9      L          L   OUTSIDE RANGE           
REMARK 500    ALA C1080        21.9      L          L   OUTSIDE RANGE           
REMARK 500    LEU C1086        24.4      L          L   OUTSIDE RANGE           
REMARK 500    ILE C1098        23.2      L          L   OUTSIDE RANGE           
REMARK 500    ASN C1149        24.6      L          L   OUTSIDE RANGE           
REMARK 500    LEU C1175        24.4      L          L   OUTSIDE RANGE           
REMARK 500    GLU C1239        24.4      L          L   OUTSIDE RANGE           
REMARK 500    ASN C1289        18.9      L          L   OUTSIDE RANGE           
REMARK 500    ASN C1290        24.8      L          L   OUTSIDE RANGE           
REMARK 500    PHE C1295        24.6      L          L   OUTSIDE RANGE           
REMARK 500    THR C1316        24.4      L          L   OUTSIDE RANGE           
REMARK 500    VAL C1319        20.9      L          L   OUTSIDE RANGE           
REMARK 500    SER C1330        21.8      L          L   OUTSIDE RANGE           
REMARK 500    ARG C1332        20.9      L          L   OUTSIDE RANGE           
REMARK 500    THR D  39        46.3      L          L   OUTSIDE RANGE           
REMARK 500    LEU D  41        23.3      L          L   OUTSIDE RANGE           
REMARK 500    ASP D  59        24.5      L          L   OUTSIDE RANGE           
REMARK 500    VAL D  66        24.9      L          L   OUTSIDE RANGE           
REMARK 500    ASN D  71        24.7      L          L   OUTSIDE RANGE           
REMARK 500    ILE D  77        21.9      L          L   OUTSIDE RANGE           
REMARK 500    THR D  96        22.4      L          L   OUTSIDE RANGE           
REMARK 500    THR D 117        22.8      L          L   OUTSIDE RANGE           
REMARK 500    ARG D 165        10.7      L          L   OUTSIDE RANGE           
REMARK 500    LEU D 195        24.0      L          L   OUTSIDE RANGE           
REMARK 500    ILE D 307        24.1      L          L   OUTSIDE RANGE           
REMARK 500    VAL D 316        24.5      L          L   OUTSIDE RANGE           
REMARK 500    LYS D 340        23.6      L          L   OUTSIDE RANGE           
REMARK 500    VAL D 345        21.0      L          L   OUTSIDE RANGE           
REMARK 500    ALA D 355        23.8      L          L   OUTSIDE RANGE           
REMARK 500    THR D 382        20.6      L          L   OUTSIDE RANGE           
REMARK 500    ASP D 430        16.1      L          L   OUTSIDE RANGE           
REMARK 500    ILE D 431        15.9      L          L   OUTSIDE RANGE           
REMARK 500    ALA D 453        23.4      L          L   OUTSIDE RANGE           
REMARK 500    ILE D 464        21.0      L          L   OUTSIDE RANGE           
REMARK 500    LEU D 467        22.8      L          L   OUTSIDE RANGE           
REMARK 500    SER D 475        20.8      L          L   OUTSIDE RANGE           
REMARK 500    GLU D 480        24.5      L          L   OUTSIDE RANGE           
REMARK 500    GLN D 529        22.2      L          L   OUTSIDE RANGE           
REMARK 500    GLU D 530        23.1      L          L   OUTSIDE RANGE           
REMARK 500    ASP D 534        21.1      L          L   OUTSIDE RANGE           
REMARK 500    LYS D 538        22.7      L          L   OUTSIDE RANGE           
REMARK 500    ASP D 540        22.9      L          L   OUTSIDE RANGE           
REMARK 500    GLU D 590        24.9      L          L   OUTSIDE RANGE           
REMARK 500    CYS D 594        21.1      L          L   OUTSIDE RANGE           
REMARK 500    ALA D 614        23.1      L          L   OUTSIDE RANGE           
REMARK 500    ASP D 622        24.3      L          L   OUTSIDE RANGE           
REMARK 500    GLU D 653        24.3      L          L   OUTSIDE RANGE           
REMARK 500    PHE D 708        13.4      L          L   OUTSIDE RANGE           
REMARK 500    TYR D 709        22.6      L          L   OUTSIDE RANGE           
REMARK 500    VAL D 731        20.0      L          L   OUTSIDE RANGE           
REMARK 500    VAL D 753        24.0      L          L   OUTSIDE RANGE           
REMARK 500    LYS D 802        22.9      L          L   OUTSIDE RANGE           
REMARK 500    GLN D 919        23.4      L          L   OUTSIDE RANGE           
REMARK 500    MET D 937        21.9      L          L   OUTSIDE RANGE           
REMARK 500    ASN D 946        21.7      L          L   OUTSIDE RANGE           
REMARK 500    LEU D 953        22.6      L          L   OUTSIDE RANGE           
REMARK 500    ARG D 967        24.1      L          L   OUTSIDE RANGE           
REMARK 500    ARG D 981        24.4      L          L   OUTSIDE RANGE           
REMARK 500    THR D1011        24.6      L          L   OUTSIDE RANGE           
REMARK 500    PHE D1014        24.8      L          L   OUTSIDE RANGE           
REMARK 500    THR D1119        24.7      L          L   OUTSIDE RANGE           
REMARK 500    SER D1127        24.9      L          L   OUTSIDE RANGE           
REMARK 500    THR D1208        24.7      L          L   OUTSIDE RANGE           
REMARK 500    ARG D1223        24.6      L          L   OUTSIDE RANGE           
REMARK 500    ILE D1254        22.6      L          L   OUTSIDE RANGE           
REMARK 500    VAL D1260        24.2      L          L   OUTSIDE RANGE           
REMARK 500    ASN D1289        20.8      L          L   OUTSIDE RANGE           
REMARK 500    ASN D1290        24.5      L          L   OUTSIDE RANGE           
REMARK 500    VAL D1291        24.6      L          L   OUTSIDE RANGE           
REMARK 500    SER D1299        24.6      L          L   OUTSIDE RANGE           
REMARK 500    VAL D1311        19.7      L          L   OUTSIDE RANGE           
REMARK 500    VAL D1319        17.1      L          L   OUTSIDE RANGE           
REMARK 500    LYS D1327        21.5      L          L   OUTSIDE RANGE           
REMARK 500    VAL D1331        18.8      L          L   OUTSIDE RANGE           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620  (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;              
REMARK 620   SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                           
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES A3001  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 FES A3001   S1                                                     
REMARK 620 2 CYS A 148   SG  106.6                                              
REMARK 620 3 FES A3001  FE2   52.4 120.5                                        
REMARK 620 4 FES A3001   S2  104.6 112.0  52.2                                  
REMARK 620 5 CYS A 116   SG  119.1  94.4 145.1 119.2                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES A3001  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 FES A3001   S1                                                     
REMARK 620 2 CYS A 113   SG  110.0                                              
REMARK 620 3 FES A3001  FE1   52.9 127.6                                        
REMARK 620 4 CYS A 150   SG  113.1 106.7 125.7                                  
REMARK 620 5 FES A3001   S2  106.3 110.5  53.5 110.3                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES A3002  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS A  48   SG                                                     
REMARK 620 2 CYS A  43   SG  110.3                                              
REMARK 620 3 FES A3002  FE2  123.7 109.7                                        
REMARK 620 4 FES A3002   S1  142.9 104.0  52.4                                  
REMARK 620 5 FES A3002   S2   84.8  97.3  52.2 104.6                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES A3002  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS A  51   SG                                                     
REMARK 620 2 FES A3002  FE1  122.1                                              
REMARK 620 3 FES A3002   S1   85.6  52.9                                        
REMARK 620 4 FES A3002   S2  138.4  53.5 106.3                                  
REMARK 620 5 CYS A  73   SG   79.0 131.5  91.3 138.3                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES B3001  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 FES B3001   S2                                                     
REMARK 620 2 CYS B 116   SG  115.1                                              
REMARK 620 3 CYS B 148   SG   95.7  90.8                                        
REMARK 620 4 FES B3001  FE2   52.2 151.4 114.4                                  
REMARK 620 5 FES B3001   S1  104.5 129.1 116.4  52.4                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES B3001  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 FES B3001   S2                                                     
REMARK 620 2 FES B3001  FE1   53.5                                              
REMARK 620 3 CYS B 150   SG  115.0 128.9                                        
REMARK 620 4 CYS B 113   SG  120.4 128.2 101.3                                  
REMARK 620 5 FES B3001   S1  106.4  52.9 111.3 101.8                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES B3002  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B  43   SG                                                     
REMARK 620 2 FES B3002   S1  109.1                                              
REMARK 620 3 FES B3002  FE2  118.2  52.4                                        
REMARK 620 4 CYS B  48   SG  105.1 138.6 126.1                                  
REMARK 620 5 FES B3002   S2  102.0 104.6  52.2  90.2                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES B3002  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 FES B3002   S1                                                     
REMARK 620 2 CYS B  51   SG   88.8                                              
REMARK 620 3 CYS B  73   SG   90.1  77.8                                        
REMARK 620 4 FES B3002  FE1   52.9 130.4 125.2                                  
REMARK 620 5 FES B3002   S2  106.3 145.9 131.0  53.5                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES C3001  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 FES C3001   S1                                                     
REMARK 620 2 CYS C 116   SG  127.1                                              
REMARK 620 3 FES C3001  FE2   52.4 138.5                                        
REMARK 620 4 FES C3001   S2  104.6 106.6  52.2                                  
REMARK 620 5 CYS C 148   SG  106.8  98.6 122.0 113.4                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES C3001  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 FES C3001   S1                                                     
REMARK 620 2 CYS C 113   SG  117.5                                              
REMARK 620 3 FES C3001  FE1   52.9 137.7                                        
REMARK 620 4 FES C3001   S2  106.3 113.2  53.5                                  
REMARK 620 5 CYS C 150   SG  111.2  92.9 129.4 115.8                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES C3002  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 FES C3002   S2                                                     
REMARK 620 2 FES C3002  FE2   52.2                                              
REMARK 620 3 FES C3002   S1  104.6  52.4                                        
REMARK 620 4 CYS C  48   SG  102.0 139.0 138.0                                  
REMARK 620 5 CYS C  43   SG   97.8 117.5 112.7  95.0                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES C3002  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 FES C3002   S2                                                     
REMARK 620 2 CYS C  51   SG  136.6                                              
REMARK 620 3 CYS C  73   SG  126.2  83.2                                        
REMARK 620 4 FES C3002  FE1   53.5 126.1 139.7                                  
REMARK 620 5 FES C3002   S1  106.3  90.8 107.1  52.9                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES D3001  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS D 148   SG                                                     
REMARK 620 2 FES D3001   S2  102.5                                              
REMARK 620 3 CYS D 116   SG   96.8 118.6                                        
REMARK 620 4 FES D3001  FE2  122.1  52.2 140.7                                  
REMARK 620 5 FES D3001   S1  118.7 104.6 115.6  52.5                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES D3001  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 FES D3001  FE1                                                     
REMARK 620 2 FES D3001   S2   53.5                                              
REMARK 620 3 CYS D 113   SG  141.9 121.4                                        
REMARK 620 4 CYS D 150   SG  125.0 106.6  93.1                                  
REMARK 620 5 FES D3001   S1   52.9 106.4 112.7 116.6                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES D3002  FE1                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS D  43   SG                                                     
REMARK 620 2 FES D3002   S2  121.4                                              
REMARK 620 3 CYS D  48   SG  101.6 100.6                                        
REMARK 620 4 FES D3002  FE2  127.7  52.2 130.4                                  
REMARK 620 5 FES D3002   S1  101.3 104.6 129.5  52.4                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FES D3002  FE2                           
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 FES D3002   S2                                                     
REMARK 620 2 CYS D  51   SG  144.9                                              
REMARK 620 3 FES D3002  FE1   53.5 126.9                                        
REMARK 620 4 FES D3002   S1  106.4  85.8  52.9                                  
REMARK 620 5 CYS D  73   SG  124.6  85.9 123.9  94.2                            
REMARK 620 N                    1     2     3     4                             
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE PO4 D3009                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FES A3001                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FES A3002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FAD A3006                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FES B3001                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FES B3002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FAD B3006                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FES C3001                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FES C3002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FAD C3006                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FES D3001                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FES D3002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FAD D3006                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL A3007                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL B3007                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL C3007                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE GOL D3007                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ACY D3008                 
DBREF  2CKJ A    1     1  PDB    2CKJ     2CKJ             1      1             
DBREF  2CKJ A    2  1333  UNP    P47989   XDH_HUMAN        1   1332             
DBREF  2CKJ B    1     1  PDB    2CKJ     2CKJ             1      1             
DBREF  2CKJ B    2  1333  UNP    P47989   XDH_HUMAN        1   1332             
DBREF  2CKJ C    1     1  PDB    2CKJ     2CKJ             1      1             
DBREF  2CKJ C    2  1333  UNP    P47989   XDH_HUMAN        1   1332             
DBREF  2CKJ D    1     1  PDB    2CKJ     2CKJ             1      1             
DBREF  2CKJ D    2  1333  UNP    P47989   XDH_HUMAN        1   1332             
SEQRES   1 A 1333  MET THR ALA ASP LYS LEU VAL PHE PHE VAL ASN GLY ARG          
SEQRES   2 A 1333  LYS VAL VAL GLU LYS ASN ALA ASP PRO GLU THR THR LEU          
SEQRES   3 A 1333  LEU ALA TYR LEU ARG ARG LYS LEU GLY LEU SER GLY THR          
SEQRES   4 A 1333  LYS LEU GLY CYS GLY GLU GLY GLY CYS GLY ALA CYS THR          
SEQRES   5 A 1333  VAL MET LEU SER LYS TYR ASP ARG LEU GLN ASN LYS ILE          
SEQRES   6 A 1333  VAL HIS PHE SER ALA ASN ALA CYS LEU ALA PRO ILE CYS          
SEQRES   7 A 1333  SER LEU HIS HIS VAL ALA VAL THR THR VAL GLU GLY ILE          
SEQRES   8 A 1333  GLY SER THR LYS THR ARG LEU HIS PRO VAL GLN GLU ARG          
SEQRES   9 A 1333  ILE ALA LYS SER HIS GLY SER GLN CYS GLY PHE CYS THR          
SEQRES  10 A 1333  PRO GLY ILE VAL MET SER MET TYR THR LEU LEU ARG ASN          
SEQRES  11 A 1333  GLN PRO GLU PRO THR MET GLU GLU ILE GLU ASN ALA PHE          
SEQRES  12 A 1333  GLN GLY ASN LEU CYS ARG CYS THR GLY TYR ARG PRO ILE          
SEQRES  13 A 1333  LEU GLN GLY PHE ARG THR PHE ALA ARG ASP GLY GLY CYS          
SEQRES  14 A 1333  CYS GLY GLY ASP GLY ASN ASN PRO ASN CYS CYS MET ASN          
SEQRES  15 A 1333  GLN LYS LYS ASP HIS SER VAL SER LEU SER PRO SER LEU          
SEQRES  16 A 1333  PHE LYS PRO GLU GLU PHE THR PRO LEU ASP PRO THR GLN          
SEQRES  17 A 1333  GLU PRO ILE PHE PRO PRO GLU LEU LEU ARG LEU LYS ASP          
SEQRES  18 A 1333  THR PRO ARG LYS GLN LEU ARG PHE GLU GLY GLU ARG VAL          
SEQRES  19 A 1333  THR TRP ILE GLN ALA SER THR LEU LYS GLU LEU LEU ASP          
SEQRES  20 A 1333  LEU LYS ALA GLN HIS PRO ASP ALA LYS LEU VAL VAL GLY          
SEQRES  21 A 1333  ASN THR GLU ILE GLY ILE GLU MET LYS PHE LYS ASN MET          
SEQRES  22 A 1333  LEU PHE PRO MET ILE VAL CYS PRO ALA TRP ILE PRO GLU          
SEQRES  23 A 1333  LEU ASN SER VAL GLU HIS GLY PRO ASP GLY ILE SER PHE          
SEQRES  24 A 1333  GLY ALA ALA CYS PRO LEU SER ILE VAL GLU LYS THR LEU          
SEQRES  25 A 1333  VAL ASP ALA VAL ALA LYS LEU PRO ALA GLN LYS THR GLU          
SEQRES  26 A 1333  VAL PHE ARG GLY VAL LEU GLU GLN LEU ARG TRP PHE ALA          
SEQRES  27 A 1333  GLY LYS GLN VAL LYS SER VAL ALA SER VAL GLY GLY ASN          
SEQRES  28 A 1333  ILE ILE THR ALA SER PRO ILE SER ASP LEU ASN PRO VAL          
SEQRES  29 A 1333  PHE MET ALA SER GLY ALA LYS LEU THR LEU VAL SER ARG          
SEQRES  30 A 1333  GLY THR ARG ARG THR VAL GLN MET ASP HIS THR PHE PHE          
SEQRES  31 A 1333  PRO GLY TYR ARG LYS THR LEU LEU SER PRO GLU GLU ILE          
SEQRES  32 A 1333  LEU LEU SER ILE GLU ILE PRO TYR SER ARG GLU GLY GLU          
SEQRES  33 A 1333  TYR PHE SER ALA PHE LYS GLN ALA SER ARG ARG GLU ASP          
SEQRES  34 A 1333  ASP ILE ALA LYS VAL THR SER GLY MET ARG VAL LEU PHE          
SEQRES  35 A 1333  LYS PRO GLY THR THR GLU VAL GLN GLU LEU ALA LEU CYS          
SEQRES  36 A 1333  TYR GLY GLY MET ALA ASN ARG THR ILE SER ALA LEU LYS          
SEQRES  37 A 1333  THR THR GLN ARG GLN LEU SER LYS LEU TRP LYS GLU GLU          
SEQRES  38 A 1333  LEU LEU GLN ASP VAL CYS ALA GLY LEU ALA GLU GLU LEU          
SEQRES  39 A 1333  HIS LEU PRO PRO ASP ALA PRO GLY GLY MET VAL ASP PHE          
SEQRES  40 A 1333  ARG CYS THR LEU THR LEU SER PHE PHE PHE LYS PHE TYR          
SEQRES  41 A 1333  LEU THR VAL LEU GLN LYS LEU GLY GLN GLU ASN LEU GLU          
SEQRES  42 A 1333  ASP LYS CYS GLY LYS LEU ASP PRO THR PHE ALA SER ALA          
SEQRES  43 A 1333  THR LEU LEU PHE GLN LYS ASP PRO PRO ALA ASP VAL GLN          
SEQRES  44 A 1333  LEU PHE GLN GLU VAL PRO LYS GLY GLN SER GLU GLU ASP          
SEQRES  45 A 1333  MET VAL GLY ARG PRO LEU PRO HIS LEU ALA ALA ASP MET          
SEQRES  46 A 1333  GLN ALA SER GLY GLU ALA VAL TYR CYS ASP ASP ILE PRO          
SEQRES  47 A 1333  ARG TYR GLU ASN GLU LEU SER LEU ARG LEU VAL THR SER          
SEQRES  48 A 1333  THR ARG ALA HIS ALA LYS ILE LYS SER ILE ASP THR SER          
SEQRES  49 A 1333  GLU ALA LYS LYS VAL PRO GLY PHE VAL CYS PHE ILE SER          
SEQRES  50 A 1333  ALA ASP ASP VAL PRO GLY SER ASN ILE THR GLY ILE CYS          
SEQRES  51 A 1333  ASN ASP GLU THR VAL PHE ALA LYS ASP LYS VAL THR CYS          
SEQRES  52 A 1333  VAL GLY HIS ILE ILE GLY ALA VAL VAL ALA ASP THR PRO          
SEQRES  53 A 1333  GLU HIS THR GLN ARG ALA ALA GLN GLY VAL LYS ILE THR          
SEQRES  54 A 1333  TYR GLU GLU LEU PRO ALA ILE ILE THR ILE GLU ASP ALA          
SEQRES  55 A 1333  ILE LYS ASN ASN SER PHE TYR GLY PRO GLU LEU LYS ILE          
SEQRES  56 A 1333  GLU LYS GLY ASP LEU LYS LYS GLY PHE SER GLU ALA ASP          
SEQRES  57 A 1333  ASN VAL VAL SER GLY GLU ILE TYR ILE GLY GLY GLN GLU          
SEQRES  58 A 1333  HIS PHE TYR LEU GLU THR HIS CYS THR ILE ALA VAL PRO          
SEQRES  59 A 1333  LYS GLY GLU ALA GLY GLU MET GLU LEU PHE VAL SER THR          
SEQRES  60 A 1333  GLN ASN THR MET LYS THR GLN SER PHE VAL ALA LYS MET          
SEQRES  61 A 1333  LEU GLY VAL PRO ALA ASN ARG ILE VAL VAL ARG VAL LYS          
SEQRES  62 A 1333  ARG MET GLY GLY GLY PHE GLY GLY LYS GLU THR ARG SER          
SEQRES  63 A 1333  THR VAL VAL SER THR ALA VAL ALA LEU ALA ALA TYR LYS          
SEQRES  64 A 1333  THR GLY ARG PRO VAL ARG CYS MET LEU ASP ARG ASP GLU          
SEQRES  65 A 1333  ASP MET LEU ILE THR GLY GLY ARG HIS PRO PHE LEU ALA          
SEQRES  66 A 1333  ARG TYR LYS VAL GLY PHE MET LYS THR GLY THR VAL VAL          
SEQRES  67 A 1333  ALA LEU GLU VAL ASP HIS PHE SER ASN VAL GLY ASN THR          
SEQRES  68 A 1333  GLN ASP LEU SER GLN SER ILE MET GLU ARG ALA LEU PHE          
SEQRES  69 A 1333  HIS MET ASP ASN CYS TYR LYS ILE PRO ASN ILE ARG GLY          
SEQRES  70 A 1333  THR GLY ARG LEU CYS LYS THR ASN LEU PRO SER ASN THR          
SEQRES  71 A 1333  ALA PHE ARG GLY PHE GLY GLY PRO GLN GLY MET LEU ILE          
SEQRES  72 A 1333  ALA GLU CYS TRP MET SER GLU VAL ALA VAL THR CYS GLY          
SEQRES  73 A 1333  MET PRO ALA GLU GLU VAL ARG ARG LYS ASN LEU TYR LYS          
SEQRES  74 A 1333  GLU GLY ASP LEU THR HIS PHE ASN GLN LYS LEU GLU GLY          
SEQRES  75 A 1333  PHE THR LEU PRO ARG CYS TRP GLU GLU CYS LEU ALA SER          
SEQRES  76 A 1333  SER GLN TYR HIS ALA ARG LYS SER GLU VAL ASP LYS PHE          
SEQRES  77 A 1333  ASN LYS GLU ASN CYS TRP LYS LYS ARG GLY LEU CYS ILE          
SEQRES  78 A 1333  ILE PRO THR LYS PHE GLY ILE SER PHE THR VAL PRO PHE          
SEQRES  79 A 1333  LEU ASN GLN ALA GLY ALA LEU LEU HIS VAL TYR THR ASP          
SEQRES  80 A 1333  GLY SER VAL LEU LEU THR HIS GLY GLY THR GLU MET GLY          
SEQRES  81 A 1333  GLN GLY LEU HIS THR LYS MET VAL GLN VAL ALA SER ARG          
SEQRES  82 A 1333  ALA LEU LYS ILE PRO THR SER LYS ILE TYR ILE SER GLU          
SEQRES  83 A 1333  THR SER THR ASN THR VAL PRO ASN THR SER PRO THR ALA          
SEQRES  84 A 1333  ALA SER VAL SER ALA ASP LEU ASN GLY GLN ALA VAL TYR          
SEQRES  85 A 1333  ALA ALA CYS GLN THR ILE LEU LYS ARG LEU GLU PRO TYR          
SEQRES  86 A 1333  LYS LYS LYS ASN PRO SER GLY SER TRP GLU ASP TRP VAL          
SEQRES  87 A 1333  THR ALA ALA TYR MET ASP THR VAL SER LEU SER ALA THR          
SEQRES  88 A 1333  GLY PHE TYR ARG THR PRO ASN LEU GLY TYR SER PHE GLU          
SEQRES  89 A 1333  THR ASN SER GLY ASN PRO PHE HIS TYR PHE SER TYR GLY          
SEQRES  90 A 1333  VAL ALA CYS SER GLU VAL GLU ILE ASP CYS LEU THR GLY          
SEQRES  91 A 1333  ASP HIS LYS ASN LEU ARG THR ASP ILE VAL MET ASP VAL          
SEQRES  92 A 1333  GLY SER SER LEU ASN PRO ALA ILE ASP ILE GLY GLN VAL          
SEQRES  93 A 1333  GLU GLY ALA PHE VAL GLN GLY LEU GLY LEU PHE THR LEU          
SEQRES  94 A 1333  GLU GLU LEU HIS TYR SER PRO GLU GLY SER LEU HIS THR          
SEQRES  95 A 1333  ARG GLY PRO SER THR TYR LYS ILE PRO ALA PHE GLY SER          
SEQRES  96 A 1333  ILE PRO ILE GLU PHE ARG VAL SER LEU LEU ARG ASP CYS          
SEQRES  97 A 1333  PRO ASN LYS LYS ALA ILE TYR ALA SER LYS ALA VAL GLY          
SEQRES  98 A 1333  GLU PRO PRO LEU PHE LEU ALA ALA SER ILE PHE PHE ALA          
SEQRES  99 A 1333  ILE LYS ASP ALA ILE ARG ALA ALA ARG ALA GLN HIS THR          
SEQRES 100 A 1333  GLY ASN ASN VAL LYS GLU LEU PHE ARG LEU ASP SER PRO          
SEQRES 101 A 1333  ALA THR PRO GLU LYS ILE ARG ASN ALA CYS VAL ASP LYS          
SEQRES 102 A 1333  PHE THR THR LEU CYS VAL THR GLY VAL PRO GLU ASN CYS          
SEQRES 103 A 1333  LYS PRO TRP SER VAL ARG VAL                                  
SEQRES   1 B 1333  MET THR ALA ASP LYS LEU VAL PHE PHE VAL ASN GLY ARG          
SEQRES   2 B 1333  LYS VAL VAL GLU LYS ASN ALA ASP PRO GLU THR THR LEU          
SEQRES   3 B 1333  LEU ALA TYR LEU ARG ARG LYS LEU GLY LEU SER GLY THR          
SEQRES   4 B 1333  LYS LEU GLY CYS GLY GLU GLY GLY CYS GLY ALA CYS THR          
SEQRES   5 B 1333  VAL MET LEU SER LYS TYR ASP ARG LEU GLN ASN LYS ILE          
SEQRES   6 B 1333  VAL HIS PHE SER ALA ASN ALA CYS LEU ALA PRO ILE CYS          
SEQRES   7 B 1333  SER LEU HIS HIS VAL ALA VAL THR THR VAL GLU GLY ILE          
SEQRES   8 B 1333  GLY SER THR LYS THR ARG LEU HIS PRO VAL GLN GLU ARG          
SEQRES   9 B 1333  ILE ALA LYS SER HIS GLY SER GLN CYS GLY PHE CYS THR          
SEQRES  10 B 1333  PRO GLY ILE VAL MET SER MET TYR THR LEU LEU ARG ASN          
SEQRES  11 B 1333  GLN PRO GLU PRO THR MET GLU GLU ILE GLU ASN ALA PHE          
SEQRES  12 B 1333  GLN GLY ASN LEU CYS ARG CYS THR GLY TYR ARG PRO ILE          
SEQRES  13 B 1333  LEU GLN GLY PHE ARG THR PHE ALA ARG ASP GLY GLY CYS          
SEQRES  14 B 1333  CYS GLY GLY ASP GLY ASN ASN PRO ASN CYS CYS MET ASN          
SEQRES  15 B 1333  GLN LYS LYS ASP HIS SER VAL SER LEU SER PRO SER LEU          
SEQRES  16 B 1333  PHE LYS PRO GLU GLU PHE THR PRO LEU ASP PRO THR GLN          
SEQRES  17 B 1333  GLU PRO ILE PHE PRO PRO GLU LEU LEU ARG LEU LYS ASP          
SEQRES  18 B 1333  THR PRO ARG LYS GLN LEU ARG PHE GLU GLY GLU ARG VAL          
SEQRES  19 B 1333  THR TRP ILE GLN ALA SER THR LEU LYS GLU LEU LEU ASP          
SEQRES  20 B 1333  LEU LYS ALA GLN HIS PRO ASP ALA LYS LEU VAL VAL GLY          
SEQRES  21 B 1333  ASN THR GLU ILE GLY ILE GLU MET LYS PHE LYS ASN MET          
SEQRES  22 B 1333  LEU PHE PRO MET ILE VAL CYS PRO ALA TRP ILE PRO GLU          
SEQRES  23 B 1333  LEU ASN SER VAL GLU HIS GLY PRO ASP GLY ILE SER PHE          
SEQRES  24 B 1333  GLY ALA ALA CYS PRO LEU SER ILE VAL GLU LYS THR LEU          
SEQRES  25 B 1333  VAL ASP ALA VAL ALA LYS LEU PRO ALA GLN LYS THR GLU          
SEQRES  26 B 1333  VAL PHE ARG GLY VAL LEU GLU GLN LEU ARG TRP PHE ALA          
SEQRES  27 B 1333  GLY LYS GLN VAL LYS SER VAL ALA SER VAL GLY GLY ASN          
SEQRES  28 B 1333  ILE ILE THR ALA SER PRO ILE SER ASP LEU ASN PRO VAL          
SEQRES  29 B 1333  PHE MET ALA SER GLY ALA LYS LEU THR LEU VAL SER ARG          
SEQRES  30 B 1333  GLY THR ARG ARG THR VAL GLN MET ASP HIS THR PHE PHE          
SEQRES  31 B 1333  PRO GLY TYR ARG LYS THR LEU LEU SER PRO GLU GLU ILE          
SEQRES  32 B 1333  LEU LEU SER ILE GLU ILE PRO TYR SER ARG GLU GLY GLU          
SEQRES  33 B 1333  TYR PHE SER ALA PHE LYS GLN ALA SER ARG ARG GLU ASP          
SEQRES  34 B 1333  ASP ILE ALA LYS VAL THR SER GLY MET ARG VAL LEU PHE          
SEQRES  35 B 1333  LYS PRO GLY THR THR GLU VAL GLN GLU LEU ALA LEU CYS          
SEQRES  36 B 1333  TYR GLY GLY MET ALA ASN ARG THR ILE SER ALA LEU LYS          
SEQRES  37 B 1333  THR THR GLN ARG GLN LEU SER LYS LEU TRP LYS GLU GLU          
SEQRES  38 B 1333  LEU LEU GLN ASP VAL CYS ALA GLY LEU ALA GLU GLU LEU          
SEQRES  39 B 1333  HIS LEU PRO PRO ASP ALA PRO GLY GLY MET VAL ASP PHE          
SEQRES  40 B 1333  ARG CYS THR LEU THR LEU SER PHE PHE PHE LYS PHE TYR          
SEQRES  41 B 1333  LEU THR VAL LEU GLN LYS LEU GLY GLN GLU ASN LEU GLU          
SEQRES  42 B 1333  ASP LYS CYS GLY LYS LEU ASP PRO THR PHE ALA SER ALA          
SEQRES  43 B 1333  THR LEU LEU PHE GLN LYS ASP PRO PRO ALA ASP VAL GLN          
SEQRES  44 B 1333  LEU PHE GLN GLU VAL PRO LYS GLY GLN SER GLU GLU ASP          
SEQRES  45 B 1333  MET VAL GLY ARG PRO LEU PRO HIS LEU ALA ALA ASP MET          
SEQRES  46 B 1333  GLN ALA SER GLY GLU ALA VAL TYR CYS ASP ASP ILE PRO          
SEQRES  47 B 1333  ARG TYR GLU ASN GLU LEU SER LEU ARG LEU VAL THR SER          
SEQRES  48 B 1333  THR ARG ALA HIS ALA LYS ILE LYS SER ILE ASP THR SER          
SEQRES  49 B 1333  GLU ALA LYS LYS VAL PRO GLY PHE VAL CYS PHE ILE SER          
SEQRES  50 B 1333  ALA ASP ASP VAL PRO GLY SER ASN ILE THR GLY ILE CYS          
SEQRES  51 B 1333  ASN ASP GLU THR VAL PHE ALA LYS ASP LYS VAL THR CYS          
SEQRES  52 B 1333  VAL GLY HIS ILE ILE GLY ALA VAL VAL ALA ASP THR PRO          
SEQRES  53 B 1333  GLU HIS THR GLN ARG ALA ALA GLN GLY VAL LYS ILE THR          
SEQRES  54 B 1333  TYR GLU GLU LEU PRO ALA ILE ILE THR ILE GLU ASP ALA          
SEQRES  55 B 1333  ILE LYS ASN ASN SER PHE TYR GLY PRO GLU LEU LYS ILE          
SEQRES  56 B 1333  GLU LYS GLY ASP LEU LYS LYS GLY PHE SER GLU ALA ASP          
SEQRES  57 B 1333  ASN VAL VAL SER GLY GLU ILE TYR ILE GLY GLY GLN GLU          
SEQRES  58 B 1333  HIS PHE TYR LEU GLU THR HIS CYS THR ILE ALA VAL PRO          
SEQRES  59 B 1333  LYS GLY GLU ALA GLY GLU MET GLU LEU PHE VAL SER THR          
SEQRES  60 B 1333  GLN ASN THR MET LYS THR GLN SER PHE VAL ALA LYS MET          
SEQRES  61 B 1333  LEU GLY VAL PRO ALA ASN ARG ILE VAL VAL ARG VAL LYS          
SEQRES  62 B 1333  ARG MET GLY GLY GLY PHE GLY GLY LYS GLU THR ARG SER          
SEQRES  63 B 1333  THR VAL VAL SER THR ALA VAL ALA LEU ALA ALA TYR LYS          
SEQRES  64 B 1333  THR GLY ARG PRO VAL ARG CYS MET LEU ASP ARG ASP GLU          
SEQRES  65 B 1333  ASP MET LEU ILE THR GLY GLY ARG HIS PRO PHE LEU ALA          
SEQRES  66 B 1333  ARG TYR LYS VAL GLY PHE MET LYS THR GLY THR VAL VAL          
SEQRES  67 B 1333  ALA LEU GLU VAL ASP HIS PHE SER ASN VAL GLY ASN THR          
SEQRES  68 B 1333  GLN ASP LEU SER GLN SER ILE MET GLU ARG ALA LEU PHE          
SEQRES  69 B 1333  HIS MET ASP ASN CYS TYR LYS ILE PRO ASN ILE ARG GLY          
SEQRES  70 B 1333  THR GLY ARG LEU CYS LYS THR ASN LEU PRO SER ASN THR          
SEQRES  71 B 1333  ALA PHE ARG GLY PHE GLY GLY PRO GLN GLY MET LEU ILE          
SEQRES  72 B 1333  ALA GLU CYS TRP MET SER GLU VAL ALA VAL THR CYS GLY          
SEQRES  73 B 1333  MET PRO ALA GLU GLU VAL ARG ARG LYS ASN LEU TYR LYS          
SEQRES  74 B 1333  GLU GLY ASP LEU THR HIS PHE ASN GLN LYS LEU GLU GLY          
SEQRES  75 B 1333  PHE THR LEU PRO ARG CYS TRP GLU GLU CYS LEU ALA SER          
SEQRES  76 B 1333  SER GLN TYR HIS ALA ARG LYS SER GLU VAL ASP LYS PHE          
SEQRES  77 B 1333  ASN LYS GLU ASN CYS TRP LYS LYS ARG GLY LEU CYS ILE          
SEQRES  78 B 1333  ILE PRO THR LYS PHE GLY ILE SER PHE THR VAL PRO PHE          
SEQRES  79 B 1333  LEU ASN GLN ALA GLY ALA LEU LEU HIS VAL TYR THR ASP          
SEQRES  80 B 1333  GLY SER VAL LEU LEU THR HIS GLY GLY THR GLU MET GLY          
SEQRES  81 B 1333  GLN GLY LEU HIS THR LYS MET VAL GLN VAL ALA SER ARG          
SEQRES  82 B 1333  ALA LEU LYS ILE PRO THR SER LYS ILE TYR ILE SER GLU          
SEQRES  83 B 1333  THR SER THR ASN THR VAL PRO ASN THR SER PRO THR ALA          
SEQRES  84 B 1333  ALA SER VAL SER ALA ASP LEU ASN GLY GLN ALA VAL TYR          
SEQRES  85 B 1333  ALA ALA CYS GLN THR ILE LEU LYS ARG LEU GLU PRO TYR          
SEQRES  86 B 1333  LYS LYS LYS ASN PRO SER GLY SER TRP GLU ASP TRP VAL          
SEQRES  87 B 1333  THR ALA ALA TYR MET ASP THR VAL SER LEU SER ALA THR          
SEQRES  88 B 1333  GLY PHE TYR ARG THR PRO ASN LEU GLY TYR SER PHE GLU          
SEQRES  89 B 1333  THR ASN SER GLY ASN PRO PHE HIS TYR PHE SER TYR GLY          
SEQRES  90 B 1333  VAL ALA CYS SER GLU VAL GLU ILE ASP CYS LEU THR GLY          
SEQRES  91 B 1333  ASP HIS LYS ASN LEU ARG THR ASP ILE VAL MET ASP VAL          
SEQRES  92 B 1333  GLY SER SER LEU ASN PRO ALA ILE ASP ILE GLY GLN VAL          
SEQRES  93 B 1333  GLU GLY ALA PHE VAL GLN GLY LEU GLY LEU PHE THR LEU          
SEQRES  94 B 1333  GLU GLU LEU HIS TYR SER PRO GLU GLY SER LEU HIS THR          
SEQRES  95 B 1333  ARG GLY PRO SER THR TYR LYS ILE PRO ALA PHE GLY SER          
SEQRES  96 B 1333  ILE PRO ILE GLU PHE ARG VAL SER LEU LEU ARG ASP CYS          
SEQRES  97 B 1333  PRO ASN LYS LYS ALA ILE TYR ALA SER LYS ALA VAL GLY          
SEQRES  98 B 1333  GLU PRO PRO LEU PHE LEU ALA ALA SER ILE PHE PHE ALA          
SEQRES  99 B 1333  ILE LYS ASP ALA ILE ARG ALA ALA ARG ALA GLN HIS THR          
SEQRES 100 B 1333  GLY ASN ASN VAL LYS GLU LEU PHE ARG LEU ASP SER PRO          
SEQRES 101 B 1333  ALA THR PRO GLU LYS ILE ARG ASN ALA CYS VAL ASP LYS          
SEQRES 102 B 1333  PHE THR THR LEU CYS VAL THR GLY VAL PRO GLU ASN CYS          
SEQRES 103 B 1333  LYS PRO TRP SER VAL ARG VAL                                  
SEQRES   1 C 1333  MET THR ALA ASP LYS LEU VAL PHE PHE VAL ASN GLY ARG          
SEQRES   2 C 1333  LYS VAL VAL GLU LYS ASN ALA ASP PRO GLU THR THR LEU          
SEQRES   3 C 1333  LEU ALA TYR LEU ARG ARG LYS LEU GLY LEU SER GLY THR          
SEQRES   4 C 1333  LYS LEU GLY CYS GLY GLU GLY GLY CYS GLY ALA CYS THR          
SEQRES   5 C 1333  VAL MET LEU SER LYS TYR ASP ARG LEU GLN ASN LYS ILE          
SEQRES   6 C 1333  VAL HIS PHE SER ALA ASN ALA CYS LEU ALA PRO ILE CYS          
SEQRES   7 C 1333  SER LEU HIS HIS VAL ALA VAL THR THR VAL GLU GLY ILE          
SEQRES   8 C 1333  GLY SER THR LYS THR ARG LEU HIS PRO VAL GLN GLU ARG          
SEQRES   9 C 1333  ILE ALA LYS SER HIS GLY SER GLN CYS GLY PHE CYS THR          
SEQRES  10 C 1333  PRO GLY ILE VAL MET SER MET TYR THR LEU LEU ARG ASN          
SEQRES  11 C 1333  GLN PRO GLU PRO THR MET GLU GLU ILE GLU ASN ALA PHE          
SEQRES  12 C 1333  GLN GLY ASN LEU CYS ARG CYS THR GLY TYR ARG PRO ILE          
SEQRES  13 C 1333  LEU GLN GLY PHE ARG THR PHE ALA ARG ASP GLY GLY CYS          
SEQRES  14 C 1333  CYS GLY GLY ASP GLY ASN ASN PRO ASN CYS CYS MET ASN          
SEQRES  15 C 1333  GLN LYS LYS ASP HIS SER VAL SER LEU SER PRO SER LEU          
SEQRES  16 C 1333  PHE LYS PRO GLU GLU PHE THR PRO LEU ASP PRO THR GLN          
SEQRES  17 C 1333  GLU PRO ILE PHE PRO PRO GLU LEU LEU ARG LEU LYS ASP          
SEQRES  18 C 1333  THR PRO ARG LYS GLN LEU ARG PHE GLU GLY GLU ARG VAL          
SEQRES  19 C 1333  THR TRP ILE GLN ALA SER THR LEU LYS GLU LEU LEU ASP          
SEQRES  20 C 1333  LEU LYS ALA GLN HIS PRO ASP ALA LYS LEU VAL VAL GLY          
SEQRES  21 C 1333  ASN THR GLU ILE GLY ILE GLU MET LYS PHE LYS ASN MET          
SEQRES  22 C 1333  LEU PHE PRO MET ILE VAL CYS PRO ALA TRP ILE PRO GLU          
SEQRES  23 C 1333  LEU ASN SER VAL GLU HIS GLY PRO ASP GLY ILE SER PHE          
SEQRES  24 C 1333  GLY ALA ALA CYS PRO LEU SER ILE VAL GLU LYS THR LEU          
SEQRES  25 C 1333  VAL ASP ALA VAL ALA LYS LEU PRO ALA GLN LYS THR GLU          
SEQRES  26 C 1333  VAL PHE ARG GLY VAL LEU GLU GLN LEU ARG TRP PHE ALA          
SEQRES  27 C 1333  GLY LYS GLN VAL LYS SER VAL ALA SER VAL GLY GLY ASN          
SEQRES  28 C 1333  ILE ILE THR ALA SER PRO ILE SER ASP LEU ASN PRO VAL          
SEQRES  29 C 1333  PHE MET ALA SER GLY ALA LYS LEU THR LEU VAL SER ARG          
SEQRES  30 C 1333  GLY THR ARG ARG THR VAL GLN MET ASP HIS THR PHE PHE          
SEQRES  31 C 1333  PRO GLY TYR ARG LYS THR LEU LEU SER PRO GLU GLU ILE          
SEQRES  32 C 1333  LEU LEU SER ILE GLU ILE PRO TYR SER ARG GLU GLY GLU          
SEQRES  33 C 1333  TYR PHE SER ALA PHE LYS GLN ALA SER ARG ARG GLU ASP          
SEQRES  34 C 1333  ASP ILE ALA LYS VAL THR SER GLY MET ARG VAL LEU PHE          
SEQRES  35 C 1333  LYS PRO GLY THR THR GLU VAL GLN GLU LEU ALA LEU CYS          
SEQRES  36 C 1333  TYR GLY GLY MET ALA ASN ARG THR ILE SER ALA LEU LYS          
SEQRES  37 C 1333  THR THR GLN ARG GLN LEU SER LYS LEU TRP LYS GLU GLU          
SEQRES  38 C 1333  LEU LEU GLN ASP VAL CYS ALA GLY LEU ALA GLU GLU LEU          
SEQRES  39 C 1333  HIS LEU PRO PRO ASP ALA PRO GLY GLY MET VAL ASP PHE          
SEQRES  40 C 1333  ARG CYS THR LEU THR LEU SER PHE PHE PHE LYS PHE TYR          
SEQRES  41 C 1333  LEU THR VAL LEU GLN LYS LEU GLY GLN GLU ASN LEU GLU          
SEQRES  42 C 1333  ASP LYS CYS GLY LYS LEU ASP PRO THR PHE ALA SER ALA          
SEQRES  43 C 1333  THR LEU LEU PHE GLN LYS ASP PRO PRO ALA ASP VAL GLN          
SEQRES  44 C 1333  LEU PHE GLN GLU VAL PRO LYS GLY GLN SER GLU GLU ASP          
SEQRES  45 C 1333  MET VAL GLY ARG PRO LEU PRO HIS LEU ALA ALA ASP MET          
SEQRES  46 C 1333  GLN ALA SER GLY GLU ALA VAL TYR CYS ASP ASP ILE PRO          
SEQRES  47 C 1333  ARG TYR GLU ASN GLU LEU SER LEU ARG LEU VAL THR SER          
SEQRES  48 C 1333  THR ARG ALA HIS ALA LYS ILE LYS SER ILE ASP THR SER          
SEQRES  49 C 1333  GLU ALA LYS LYS VAL PRO GLY PHE VAL CYS PHE ILE SER          
SEQRES  50 C 1333  ALA ASP ASP VAL PRO GLY SER ASN ILE THR GLY ILE CYS          
SEQRES  51 C 1333  ASN ASP GLU THR VAL PHE ALA LYS ASP LYS VAL THR CYS          
SEQRES  52 C 1333  VAL GLY HIS ILE ILE GLY ALA VAL VAL ALA ASP THR PRO          
SEQRES  53 C 1333  GLU HIS THR GLN ARG ALA ALA GLN GLY VAL LYS ILE THR          
SEQRES  54 C 1333  TYR GLU GLU LEU PRO ALA ILE ILE THR ILE GLU ASP ALA          
SEQRES  55 C 1333  ILE LYS ASN ASN SER PHE TYR GLY PRO GLU LEU LYS ILE          
SEQRES  56 C 1333  GLU LYS GLY ASP LEU LYS LYS GLY PHE SER GLU ALA ASP          
SEQRES  57 C 1333  ASN VAL VAL SER GLY GLU ILE TYR ILE GLY GLY GLN GLU          
SEQRES  58 C 1333  HIS PHE TYR LEU GLU THR HIS CYS THR ILE ALA VAL PRO          
SEQRES  59 C 1333  LYS GLY GLU ALA GLY GLU MET GLU LEU PHE VAL SER THR          
SEQRES  60 C 1333  GLN ASN THR MET LYS THR GLN SER PHE VAL ALA LYS MET          
SEQRES  61 C 1333  LEU GLY VAL PRO ALA ASN ARG ILE VAL VAL ARG VAL LYS          
SEQRES  62 C 1333  ARG MET GLY GLY GLY PHE GLY GLY LYS GLU THR ARG SER          
SEQRES  63 C 1333  THR VAL VAL SER THR ALA VAL ALA LEU ALA ALA TYR LYS          
SEQRES  64 C 1333  THR GLY ARG PRO VAL ARG CYS MET LEU ASP ARG ASP GLU          
SEQRES  65 C 1333  ASP MET LEU ILE THR GLY GLY ARG HIS PRO PHE LEU ALA          
SEQRES  66 C 1333  ARG TYR LYS VAL GLY PHE MET LYS THR GLY THR VAL VAL          
SEQRES  67 C 1333  ALA LEU GLU VAL ASP HIS PHE SER ASN VAL GLY ASN THR          
SEQRES  68 C 1333  GLN ASP LEU SER GLN SER ILE MET GLU ARG ALA LEU PHE          
SEQRES  69 C 1333  HIS MET ASP ASN CYS TYR LYS ILE PRO ASN ILE ARG GLY          
SEQRES  70 C 1333  THR GLY ARG LEU CYS LYS THR ASN LEU PRO SER ASN THR          
SEQRES  71 C 1333  ALA PHE ARG GLY PHE GLY GLY PRO GLN GLY MET LEU ILE          
SEQRES  72 C 1333  ALA GLU CYS TRP MET SER GLU VAL ALA VAL THR CYS GLY          
SEQRES  73 C 1333  MET PRO ALA GLU GLU VAL ARG ARG LYS ASN LEU TYR LYS          
SEQRES  74 C 1333  GLU GLY ASP LEU THR HIS PHE ASN GLN LYS LEU GLU GLY          
SEQRES  75 C 1333  PHE THR LEU PRO ARG CYS TRP GLU GLU CYS LEU ALA SER          
SEQRES  76 C 1333  SER GLN TYR HIS ALA ARG LYS SER GLU VAL ASP LYS PHE          
SEQRES  77 C 1333  ASN LYS GLU ASN CYS TRP LYS LYS ARG GLY LEU CYS ILE          
SEQRES  78 C 1333  ILE PRO THR LYS PHE GLY ILE SER PHE THR VAL PRO PHE          
SEQRES  79 C 1333  LEU ASN GLN ALA GLY ALA LEU LEU HIS VAL TYR THR ASP          
SEQRES  80 C 1333  GLY SER VAL LEU LEU THR HIS GLY GLY THR GLU MET GLY          
SEQRES  81 C 1333  GLN GLY LEU HIS THR LYS MET VAL GLN VAL ALA SER ARG          
SEQRES  82 C 1333  ALA LEU LYS ILE PRO THR SER LYS ILE TYR ILE SER GLU          
SEQRES  83 C 1333  THR SER THR ASN THR VAL PRO ASN THR SER PRO THR ALA          
SEQRES  84 C 1333  ALA SER VAL SER ALA ASP LEU ASN GLY GLN ALA VAL TYR          
SEQRES  85 C 1333  ALA ALA CYS GLN THR ILE LEU LYS ARG LEU GLU PRO TYR          
SEQRES  86 C 1333  LYS LYS LYS ASN PRO SER GLY SER TRP GLU ASP TRP VAL          
SEQRES  87 C 1333  THR ALA ALA TYR MET ASP THR VAL SER LEU SER ALA THR          
SEQRES  88 C 1333  GLY PHE TYR ARG THR PRO ASN LEU GLY TYR SER PHE GLU          
SEQRES  89 C 1333  THR ASN SER GLY ASN PRO PHE HIS TYR PHE SER TYR GLY          
SEQRES  90 C 1333  VAL ALA CYS SER GLU VAL GLU ILE ASP CYS LEU THR GLY          
SEQRES  91 C 1333  ASP HIS LYS ASN LEU ARG THR ASP ILE VAL MET ASP VAL          
SEQRES  92 C 1333  GLY SER SER LEU ASN PRO ALA ILE ASP ILE GLY GLN VAL          
SEQRES  93 C 1333  GLU GLY ALA PHE VAL GLN GLY LEU GLY LEU PHE THR LEU          
SEQRES  94 C 1333  GLU GLU LEU HIS TYR SER PRO GLU GLY SER LEU HIS THR          
SEQRES  95 C 1333  ARG GLY PRO SER THR TYR LYS ILE PRO ALA PHE GLY SER          
SEQRES  96 C 1333  ILE PRO ILE GLU PHE ARG VAL SER LEU LEU ARG ASP CYS          
SEQRES  97 C 1333  PRO ASN LYS LYS ALA ILE TYR ALA SER LYS ALA VAL GLY          
SEQRES  98 C 1333  GLU PRO PRO LEU PHE LEU ALA ALA SER ILE PHE PHE ALA          
SEQRES  99 C 1333  ILE LYS ASP ALA ILE ARG ALA ALA ARG ALA GLN HIS THR          
SEQRES 100 C 1333  GLY ASN ASN VAL LYS GLU LEU PHE ARG LEU ASP SER PRO          
SEQRES 101 C 1333  ALA THR PRO GLU LYS ILE ARG ASN ALA CYS VAL ASP LYS          
SEQRES 102 C 1333  PHE THR THR LEU CYS VAL THR GLY VAL PRO GLU ASN CYS          
SEQRES 103 C 1333  LYS PRO TRP SER VAL ARG VAL                                  
SEQRES   1 D 1333  MET THR ALA ASP LYS LEU VAL PHE PHE VAL ASN GLY ARG          
SEQRES   2 D 1333  LYS VAL VAL GLU LYS ASN ALA ASP PRO GLU THR THR LEU          
SEQRES   3 D 1333  LEU ALA TYR LEU ARG ARG LYS LEU GLY LEU SER GLY THR          
SEQRES   4 D 1333  LYS LEU GLY CYS GLY GLU GLY GLY CYS GLY ALA CYS THR          
SEQRES   5 D 1333  VAL MET LEU SER LYS TYR ASP ARG LEU GLN ASN LYS ILE          
SEQRES   6 D 1333  VAL HIS PHE SER ALA ASN ALA CYS LEU ALA PRO ILE CYS          
SEQRES   7 D 1333  SER LEU HIS HIS VAL ALA VAL THR THR VAL GLU GLY ILE          
SEQRES   8 D 1333  GLY SER THR LYS THR ARG LEU HIS PRO VAL GLN GLU ARG          
SEQRES   9 D 1333  ILE ALA LYS SER HIS GLY SER GLN CYS GLY PHE CYS THR          
SEQRES  10 D 1333  PRO GLY ILE VAL MET SER MET TYR THR LEU LEU ARG ASN          
SEQRES  11 D 1333  GLN PRO GLU PRO THR MET GLU GLU ILE GLU ASN ALA PHE          
SEQRES  12 D 1333  GLN GLY ASN LEU CYS ARG CYS THR GLY TYR ARG PRO ILE          
SEQRES  13 D 1333  LEU GLN GLY PHE ARG THR PHE ALA ARG ASP GLY GLY CYS          
SEQRES  14 D 1333  CYS GLY GLY ASP GLY ASN ASN PRO ASN CYS CYS MET ASN          
SEQRES  15 D 1333  GLN LYS LYS ASP HIS SER VAL SER LEU SER PRO SER LEU          
SEQRES  16 D 1333  PHE LYS PRO GLU GLU PHE THR PRO LEU ASP PRO THR GLN          
SEQRES  17 D 1333  GLU PRO ILE PHE PRO PRO GLU LEU LEU ARG LEU LYS ASP          
SEQRES  18 D 1333  THR PRO ARG LYS GLN LEU ARG PHE GLU GLY GLU ARG VAL          
SEQRES  19 D 1333  THR TRP ILE GLN ALA SER THR LEU LYS GLU LEU LEU ASP          
SEQRES  20 D 1333  LEU LYS ALA GLN HIS PRO ASP ALA LYS LEU VAL VAL GLY          
SEQRES  21 D 1333  ASN THR GLU ILE GLY ILE GLU MET LYS PHE LYS ASN MET          
SEQRES  22 D 1333  LEU PHE PRO MET ILE VAL CYS PRO ALA TRP ILE PRO GLU          
SEQRES  23 D 1333  LEU ASN SER VAL GLU HIS GLY PRO ASP GLY ILE SER PHE          
SEQRES  24 D 1333  GLY ALA ALA CYS PRO LEU SER ILE VAL GLU LYS THR LEU          
SEQRES  25 D 1333  VAL ASP ALA VAL ALA LYS LEU PRO ALA GLN LYS THR GLU          
SEQRES  26 D 1333  VAL PHE ARG GLY VAL LEU GLU GLN LEU ARG TRP PHE ALA          
SEQRES  27 D 1333  GLY LYS GLN VAL LYS SER VAL ALA SER VAL GLY GLY ASN          
SEQRES  28 D 1333  ILE ILE THR ALA SER PRO ILE SER ASP LEU ASN PRO VAL          
SEQRES  29 D 1333  PHE MET ALA SER GLY ALA LYS LEU THR LEU VAL SER ARG          
SEQRES  30 D 1333  GLY THR ARG ARG THR VAL GLN MET ASP HIS THR PHE PHE          
SEQRES  31 D 1333  PRO GLY TYR ARG LYS THR LEU LEU SER PRO GLU GLU ILE          
SEQRES  32 D 1333  LEU LEU SER ILE GLU ILE PRO TYR SER ARG GLU GLY GLU          
SEQRES  33 D 1333  TYR PHE SER ALA PHE LYS GLN ALA SER ARG ARG GLU ASP          
SEQRES  34 D 1333  ASP ILE ALA LYS VAL THR SER GLY MET ARG VAL LEU PHE          
SEQRES  35 D 1333  LYS PRO GLY THR THR GLU VAL GLN GLU LEU ALA LEU CYS          
SEQRES  36 D 1333  TYR GLY GLY MET ALA ASN ARG THR ILE SER ALA LEU LYS          
SEQRES  37 D 1333  THR THR GLN ARG GLN LEU SER LYS LEU TRP LYS GLU GLU          
SEQRES  38 D 1333  LEU LEU GLN ASP VAL CYS ALA GLY LEU ALA GLU GLU LEU          
SEQRES  39 D 1333  HIS LEU PRO PRO ASP ALA PRO GLY GLY MET VAL ASP PHE          
SEQRES  40 D 1333  ARG CYS THR LEU THR LEU SER PHE PHE PHE LYS PHE TYR          
SEQRES  41 D 1333  LEU THR VAL LEU GLN LYS LEU GLY GLN GLU ASN LEU GLU          
SEQRES  42 D 1333  ASP LYS CYS GLY LYS LEU ASP PRO THR PHE ALA SER ALA          
SEQRES  43 D 1333  THR LEU LEU PHE GLN LYS ASP PRO PRO ALA ASP VAL GLN          
SEQRES  44 D 1333  LEU PHE GLN GLU VAL PRO LYS GLY GLN SER GLU GLU ASP          
SEQRES  45 D 1333  MET VAL GLY ARG PRO LEU PRO HIS LEU ALA ALA ASP MET          
SEQRES  46 D 1333  GLN ALA SER GLY GLU ALA VAL TYR CYS ASP ASP ILE PRO          
SEQRES  47 D 1333  ARG TYR GLU ASN GLU LEU SER LEU ARG LEU VAL THR SER          
SEQRES  48 D 1333  THR ARG ALA HIS ALA LYS ILE LYS SER ILE ASP THR SER          
SEQRES  49 D 1333  GLU ALA LYS LYS VAL PRO GLY PHE VAL CYS PHE ILE SER          
SEQRES  50 D 1333  ALA ASP ASP VAL PRO GLY SER ASN ILE THR GLY ILE CYS          
SEQRES  51 D 1333  ASN ASP GLU THR VAL PHE ALA LYS ASP LYS VAL THR CYS          
SEQRES  52 D 1333  VAL GLY HIS ILE ILE GLY ALA VAL VAL ALA ASP THR PRO          
SEQRES  53 D 1333  GLU HIS THR GLN ARG ALA ALA GLN GLY VAL LYS ILE THR          
SEQRES  54 D 1333  TYR GLU GLU LEU PRO ALA ILE ILE THR ILE GLU ASP ALA          
SEQRES  55 D 1333  ILE LYS ASN ASN SER PHE TYR GLY PRO GLU LEU LYS ILE          
SEQRES  56 D 1333  GLU LYS GLY ASP LEU LYS LYS GLY PHE SER GLU ALA ASP          
SEQRES  57 D 1333  ASN VAL VAL SER GLY GLU ILE TYR ILE GLY GLY GLN GLU          
SEQRES  58 D 1333  HIS PHE TYR LEU GLU THR HIS CYS THR ILE ALA VAL PRO          
SEQRES  59 D 1333  LYS GLY GLU ALA GLY GLU MET GLU LEU PHE VAL SER THR          
SEQRES  60 D 1333  GLN ASN THR MET LYS THR GLN SER PHE VAL ALA LYS MET          
SEQRES  61 D 1333  LEU GLY VAL PRO ALA ASN ARG ILE VAL VAL ARG VAL LYS          
SEQRES  62 D 1333  ARG MET GLY GLY GLY PHE GLY GLY LYS GLU THR ARG SER          
SEQRES  63 D 1333  THR VAL VAL SER THR ALA VAL ALA LEU ALA ALA TYR LYS          
SEQRES  64 D 1333  THR GLY ARG PRO VAL ARG CYS MET LEU ASP ARG ASP GLU          
SEQRES  65 D 1333  ASP MET LEU ILE THR GLY GLY ARG HIS PRO PHE LEU ALA          
SEQRES  66 D 1333  ARG TYR LYS VAL GLY PHE MET LYS THR GLY THR VAL VAL          
SEQRES  67 D 1333  ALA LEU GLU VAL ASP HIS PHE SER ASN VAL GLY ASN THR          
SEQRES  68 D 1333  GLN ASP LEU SER GLN SER ILE MET GLU ARG ALA LEU PHE          
SEQRES  69 D 1333  HIS MET ASP ASN CYS TYR LYS ILE PRO ASN ILE ARG GLY          
SEQRES  70 D 1333  THR GLY ARG LEU CYS LYS THR ASN LEU PRO SER ASN THR          
SEQRES  71 D 1333  ALA PHE ARG GLY PHE GLY GLY PRO GLN GLY MET LEU ILE          
SEQRES  72 D 1333  ALA GLU CYS TRP MET SER GLU VAL ALA VAL THR CYS GLY          
SEQRES  73 D 1333  MET PRO ALA GLU GLU VAL ARG ARG LYS ASN LEU TYR LYS          
SEQRES  74 D 1333  GLU GLY ASP LEU THR HIS PHE ASN GLN LYS LEU GLU GLY          
SEQRES  75 D 1333  PHE THR LEU PRO ARG CYS TRP GLU GLU CYS LEU ALA SER          
SEQRES  76 D 1333  SER GLN TYR HIS ALA ARG LYS SER GLU VAL ASP LYS PHE          
SEQRES  77 D 1333  ASN LYS GLU ASN CYS TRP LYS LYS ARG GLY LEU CYS ILE          
SEQRES  78 D 1333  ILE PRO THR LYS PHE GLY ILE SER PHE THR VAL PRO PHE          
SEQRES  79 D 1333  LEU ASN GLN ALA GLY ALA LEU LEU HIS VAL TYR THR ASP          
SEQRES  80 D 1333  GLY SER VAL LEU LEU THR HIS GLY GLY THR GLU MET GLY          
SEQRES  81 D 1333  GLN GLY LEU HIS THR LYS MET VAL GLN VAL ALA SER ARG          
SEQRES  82 D 1333  ALA LEU LYS ILE PRO THR SER LYS ILE TYR ILE SER GLU          
SEQRES  83 D 1333  THR SER THR ASN THR VAL PRO ASN THR SER PRO THR ALA          
SEQRES  84 D 1333  ALA SER VAL SER ALA ASP LEU ASN GLY GLN ALA VAL TYR          
SEQRES  85 D 1333  ALA ALA CYS GLN THR ILE LEU LYS ARG LEU GLU PRO TYR          
SEQRES  86 D 1333  LYS LYS LYS ASN PRO SER GLY SER TRP GLU ASP TRP VAL          
SEQRES  87 D 1333  THR ALA ALA TYR MET ASP THR VAL SER LEU SER ALA THR          
SEQRES  88 D 1333  GLY PHE TYR ARG THR PRO ASN LEU GLY TYR SER PHE GLU          
SEQRES  89 D 1333  THR ASN SER GLY ASN PRO PHE HIS TYR PHE SER TYR GLY          
SEQRES  90 D 1333  VAL ALA CYS SER GLU VAL GLU ILE ASP CYS LEU THR GLY          
SEQRES  91 D 1333  ASP HIS LYS ASN LEU ARG THR ASP ILE VAL MET ASP VAL          
SEQRES  92 D 1333  GLY SER SER LEU ASN PRO ALA ILE ASP ILE GLY GLN VAL          
SEQRES  93 D 1333  GLU GLY ALA PHE VAL GLN GLY LEU GLY LEU PHE THR LEU          
SEQRES  94 D 1333  GLU GLU LEU HIS TYR SER PRO GLU GLY SER LEU HIS THR          
SEQRES  95 D 1333  ARG GLY PRO SER THR TYR LYS ILE PRO ALA PHE GLY SER          
SEQRES  96 D 1333  ILE PRO ILE GLU PHE ARG VAL SER LEU LEU ARG ASP CYS          
SEQRES  97 D 1333  PRO ASN LYS LYS ALA ILE TYR ALA SER LYS ALA VAL GLY          
SEQRES  98 D 1333  GLU PRO PRO LEU PHE LEU ALA ALA SER ILE PHE PHE ALA          
SEQRES  99 D 1333  ILE LYS ASP ALA ILE ARG ALA ALA ARG ALA GLN HIS THR          
SEQRES 100 D 1333  GLY ASN ASN VAL LYS GLU LEU PHE ARG LEU ASP SER PRO          
SEQRES 101 D 1333  ALA THR PRO GLU LYS ILE ARG ASN ALA CYS VAL ASP LYS          
SEQRES 102 D 1333  PHE THR THR LEU CYS VAL THR GLY VAL PRO GLU ASN CYS          
SEQRES 103 D 1333  LYS PRO TRP SER VAL ARG VAL                                  
HET    PO4  D3009       5                                                       
HET    FES  A3001       4                                                       
HET    FES  A3002       4                                                       
HET    FAD  A3006      53                                                       
HET    FES  B3001       4                                                       
HET    FES  B3002       4                                                       
HET    FAD  B3006      53                                                       
HET    FES  C3001       4                                                       
HET    FES  C3002       4                                                       
HET    FAD  C3006      53                                                       
HET    FES  D3001       4                                                       
HET    FES  D3002       4                                                       
HET    FAD  D3006      53                                                       
HET    GOL  A3007       6                                                       
HET    GOL  B3007       6                                                       
HET    GOL  C3007       6                                                       
HET    GOL  D3007       6                                                       
HET    ACY  D3008       4                                                       
HETNAM     PO4 PHOSPHATE ION                                                    
HETNAM     FES FE2/S2 (INORGANIC) CLUSTER                                       
HETNAM     FAD FLAVIN-ADENINE DINUCLEOTIDE                                      
HETNAM     GOL GLYCEROL                                                         
HETNAM     ACY ACETIC ACID                                                      
FORMUL   5  PO4    O4 P 3-                                                      
FORMUL   6  FES    8(FE2 S2)                                                    
FORMUL   8  FAD    4(C27 H33 N9 O15 P2)                                         
FORMUL  18  GOL    4(C3 H8 O3)                                                  
FORMUL  22  ACY    C2 H4 O2                                                     
HELIX    1   1 THR A   25  LEU A   34  1                                  10    
HELIX    2   2 ILE A   77  HIS A   81  5                                   5    
HELIX    3   3 THR A   87  ILE A   91  5                                   5    
HELIX    4   4 HIS A   99  SER A  108  1                                  10    
HELIX    5   5 CYS A  116  GLN A  131  1                                  16    
HELIX    6   6 THR A  135  GLU A  140  1                                   6    
HELIX    7   7 ASN A  141  ASN A  146  5                                   6    
HELIX    8   8 TYR A  153  THR A  162  1                                  10    
HELIX    9   9 ASP A  205  GLU A  209  5                                   5    
HELIX   10  10 PRO A  214  LEU A  219  1                                   6    
HELIX   11  11 THR A  241  HIS A  252  1                                  12    
HELIX   12  12 GLU A  263  LYS A  271  1                                   9    
HELIX   13  13 ILE A  284  ASN A  288  5                                   5    
HELIX   14  14 PRO A  304  VAL A  316  1                                  13    
HELIX   15  15 THR A  324  ARG A  335  1                                  12    
HELIX   16  16 GLY A  339  SER A  344  1                                   6    
HELIX   17  17 SER A  347  THR A  354  1                                   8    
HELIX   18  18 LEU A  361  GLY A  369  1                                   9    
HELIX   19  19 LEU A  467  LEU A  474  1                                   8    
HELIX   20  20 LYS A  479  LEU A  494  1                                  16    
HELIX   21  21 MET A  504  GLN A  525  1                                  22    
HELIX   22  22 ALA A  582  SER A  588  1                                   7    
HELIX   23  23 ASP A  639  VAL A  641  5                                   3    
HELIX   24  24 THR A  675  VAL A  686  1                                  12    
HELIX   25  25 LYS A  721  GLU A  726  1                                   6    
HELIX   26  26 ASN A  769  GLY A  782  1                                  14    
HELIX   27  27 PRO A  784  ASN A  786  5                                   3    
HELIX   28  28 ARG A  805  GLY A  821  1                                  17    
HELIX   29  29 ASP A  829  THR A  837  1                                   9    
HELIX   30  30 LEU A  874  PHE A  884  1                                  11    
HELIX   31  31 CYS A  926  GLY A  936  1                                  11    
HELIX   32  32 PRO A  938  ASN A  946  1                                   9    
HELIX   33  33 THR A  964  SER A  976  1                                  13    
HELIX   34  34 GLN A  977  ASN A  992  1                                  16    
HELIX   35  35 VAL A 1012  LEU A 1015  5                                   4    
HELIX   36  36 GLY A 1042  LYS A 1056  1                                  15    
HELIX   37  37 PRO A 1058  SER A 1060  5                                   3    
HELIX   38  38 VAL A 1082  LYS A 1108  1                                  27    
HELIX   39  39 SER A 1113  THR A 1125  1                                  13    
HELIX   40  40 ALA A 1190  LEU A 1209  1                                  20    
HELIX   41  41 ALA A 1232  ILE A 1236  5                                   5    
HELIX   42  42 ALA A 1253  ALA A 1256  5                                   4    
HELIX   43  43 GLU A 1262  LEU A 1267  5                                   6    
HELIX   44  44 ALA A 1268  HIS A 1286  1                                  19    
HELIX   45  45 THR A 1302  ALA A 1309  1                                   8    
HELIX   46  46 PHE A 1314  VAL A 1319  1                                   6    
HELIX   47  47 THR B   25  LYS B   33  1                                   9    
HELIX   48  48 ILE B   77  HIS B   81  5                                   5    
HELIX   49  49 THR B   87  ILE B   91  5                                   5    
HELIX   50  50 HIS B   99  SER B  108  1                                  10    
HELIX   51  51 CYS B  116  GLN B  131  1                                  16    
HELIX   52  52 THR B  135  GLU B  140  1                                   6    
HELIX   53  53 TYR B  153  THR B  162  1                                  10    
HELIX   54  54 LYS B  197  PHE B  201  5                                   5    
HELIX   55  55 ASP B  205  GLU B  209  5                                   5    
HELIX   56  56 THR B  241  HIS B  252  1                                  12    
HELIX   57  57 GLU B  263  LYS B  271  1                                   9    
HELIX   58  58 ILE B  284  ASN B  288  5                                   5    
HELIX   59  59 PRO B  304  LYS B  318  1                                  15    
HELIX   60  60 VAL B  326  ARG B  335  1                                  10    
HELIX   61  61 GLY B  339  SER B  344  1                                   6    
HELIX   62  62 SER B  347  THR B  354  1                                   8    
HELIX   63  63 LEU B  361  GLY B  369  1                                   9    
HELIX   64  64 LEU B  467  GLN B  473  1                                   7    
HELIX   65  65 LYS B  479  LEU B  494  1                                  16    
HELIX   66  66 MET B  504  GLN B  525  1                                  22    
HELIX   67  67 ALA B  582  SER B  588  1                                   7    
HELIX   68  68 THR B  623  VAL B  629  5                                   7    
HELIX   69  69 ASP B  639  VAL B  641  5                                   3    
HELIX   70  70 THR B  675  VAL B  686  1                                  12    
HELIX   71  71 ASP B  701  ASN B  706  5                                   6    
HELIX   72  72 LYS B  721  GLU B  726  1                                   6    
HELIX   73  73 ASN B  769  GLY B  782  1                                  14    
HELIX   74  74 PRO B  784  ASN B  786  5                                   3    
HELIX   75  75 SER B  806  GLY B  821  1                                  16    
HELIX   76  76 ASP B  829  THR B  837  1                                   9    
HELIX   77  77 LEU B  874  PHE B  884  1                                  11    
HELIX   78  78 CYS B  926  GLY B  936  1                                  11    
HELIX   79  79 PRO B  938  ASN B  946  1                                   9    
HELIX   80  80 THR B  964  SER B  976  1                                  13    
HELIX   81  81 ARG B  981  ASN B  992  1                                  12    
HELIX   82  82 VAL B 1012  LEU B 1015  5                                   4    
HELIX   83  83 GLY B 1042  LYS B 1056  1                                  15    
HELIX   84  84 PRO B 1058  SER B 1060  5                                   3    
HELIX   85  85 VAL B 1082  LYS B 1108  1                                  27    
HELIX   86  86 SER B 1113  THR B 1125  1                                  13    
HELIX   87  87 ALA B 1190  LEU B 1209  1                                  20    
HELIX   88  88 ALA B 1232  ILE B 1236  5                                   5    
HELIX   89  89 ALA B 1253  ALA B 1256  5                                   4    
HELIX   90  90 GLU B 1262  LEU B 1267  5                                   6    
HELIX   91  91 ALA B 1268  THR B 1287  1                                  20    
HELIX   92  92 THR B 1302  CYS B 1310  1                                   9    
HELIX   93  93 THR C   25  LEU C   34  1                                  10    
HELIX   94  94 ILE C   77  HIS C   81  5                                   5    
HELIX   95  95 THR C   87  ILE C   91  5                                   5    
HELIX   96  96 HIS C   99  SER C  108  1                                  10    
HELIX   97  97 CYS C  116  GLN C  131  1                                  16    
HELIX   98  98 THR C  135  GLU C  140  1                                   6    
HELIX   99  99 TYR C  153  ARG C  161  1                                   9    
HELIX  100 100 THR C  162  ALA C  164  5                                   3    
HELIX  101 101 ASP C  205  GLU C  209  5                                   5    
HELIX  102 102 THR C  241  HIS C  252  1                                  12    
HELIX  103 103 GLU C  263  LYS C  271  1                                   9    
HELIX  104 104 ILE C  284  ASN C  288  5                                   5    
HELIX  105 105 PRO C  304  VAL C  316  1                                  13    
HELIX  106 106 THR C  324  ARG C  335  1                                  12    
HELIX  107 107 GLY C  339  SER C  344  1                                   6    
HELIX  108 108 SER C  347  THR C  354  1                                   8    
HELIX  109 109 LEU C  361  GLY C  369  1                                   9    
HELIX  110 110 LEU C  467  GLN C  473  1                                   7    
HELIX  111 111 LYS C  479  LEU C  494  1                                  16    
HELIX  112 112 MET C  504  GLN C  525  1                                  22    
HELIX  113 113 ALA C  582  SER C  588  1                                   7    
HELIX  114 114 ASP C  639  VAL C  641  5                                   3    
HELIX  115 115 THR C  675  VAL C  686  1                                  12    
HELIX  116 116 LYS C  721  GLU C  726  1                                   6    
HELIX  117 117 ASN C  769  GLY C  782  1                                  14    
HELIX  118 118 PRO C  784  ASN C  786  5                                   3    
HELIX  119 119 ARG C  805  GLY C  821  1                                  17    
HELIX  120 120 ASP C  829  THR C  837  1                                   9    
HELIX  121 121 LEU C  874  PHE C  884  1                                  11    
HELIX  122 122 CYS C  926  GLY C  936  1                                  11    
HELIX  123 123 PRO C  938  ASN C  946  1                                   9    
HELIX  124 124 THR C  964  GLU C  971  1                                   8    
HELIX  125 125 GLU C  971  SER C  976  1                                   6    
HELIX  126 126 GLN C  977  ASN C  992  1                                  16    
HELIX  127 127 VAL C 1012  LEU C 1015  5                                   4    
HELIX  128 128 GLY C 1042  LYS C 1056  1                                  15    
HELIX  129 129 PRO C 1058  SER C 1060  5                                   3    
HELIX  130 130 VAL C 1082  LYS C 1108  1                                  27    
HELIX  131 131 SER C 1113  THR C 1125  1                                  13    
HELIX  132 132 ALA C 1190  LEU C 1209  1                                  20    
HELIX  133 133 ALA C 1232  ILE C 1236  5                                   5    
HELIX  134 134 ALA C 1253  ALA C 1256  5                                   4    
HELIX  135 135 GLU C 1262  LEU C 1267  5                                   6    
HELIX  136 136 ALA C 1268  ALA C 1284  1                                  17    
HELIX  137 137 THR C 1302  ALA C 1309  1                                   8    
HELIX  138 138 THR D   25  LEU D   34  1                                  10    
HELIX  139 139 THR D   87  ILE D   91  5                                   5    
HELIX  140 140 HIS D   99  SER D  108  1                                  10    
HELIX  141 141 CYS D  116  GLN D  131  1                                  16    
HELIX  142 142 THR D  135  GLU D  140  1                                   6    
HELIX  143 143 TYR D  153  ARG D  161  1                                   9    
HELIX  144 144 THR D  162  ALA D  164  5                                   3    
HELIX  145 145 ASP D  205  GLU D  209  5                                   5    
HELIX  146 146 THR D  241  HIS D  252  1                                  12    
HELIX  147 147 GLU D  263  LYS D  271  1                                   9    
HELIX  148 148 ILE D  284  ASN D  288  5                                   5    
HELIX  149 149 PRO D  304  VAL D  316  1                                  13    
HELIX  150 150 GLN D  322  GLU D  325  5                                   4    
HELIX  151 151 VAL D  326  ARG D  335  1                                  10    
HELIX  152 152 GLY D  339  SER D  344  1                                   6    
HELIX  153 153 SER D  347  THR D  354  1                                   8    
HELIX  154 154 LEU D  361  GLY D  369  1                                   9    
HELIX  155 155 ASP D  386  PHE D  390  5                                   5    
HELIX  156 156 LEU D  467  GLN D  473  1                                   7    
HELIX  157 157 LYS D  479  LEU D  494  1                                  16    
HELIX  158 158 MET D  504  GLN D  525  1                                  22    
HELIX  159 159 ALA D  582  SER D  588  1                                   7    
HELIX  160 160 ASP D  639  VAL D  641  5                                   3    
HELIX  161 161 THR D  675  VAL D  686  1                                  12    
HELIX  162 162 LYS D  721  GLU D  726  1                                   6    
HELIX  163 163 ASN D  769  GLY D  782  1                                  14    
HELIX  164 164 PRO D  784  ASN D  786  5                                   3    
HELIX  165 165 ARG D  805  GLY D  821  1                                  17    
HELIX  166 166 ASP D  829  THR D  837  1                                   9    
HELIX  167 167 LEU D  874  PHE D  884  1                                  11    
HELIX  168 168 TRP D  927  GLY D  936  1                                  10    
HELIX  169 169 PRO D  938  ASN D  946  1                                   9    
HELIX  170 170 THR D  964  SER D  976  1                                  13    
HELIX  171 171 GLN D  977  ASN D  992  1                                  16    
HELIX  172 172 VAL D 1012  LEU D 1015  5                                   4    
HELIX  173 173 GLY D 1042  LYS D 1056  1                                  15    
HELIX  174 174 PRO D 1058  SER D 1060  5                                   3    
HELIX  175 175 VAL D 1082  ASN D 1109  1                                  28    
HELIX  176 176 SER D 1113  THR D 1125  1                                  13    
HELIX  177 177 ALA D 1190  LEU D 1209  1                                  20    
HELIX  178 178 ALA D 1232  ILE D 1236  5                                   5    
HELIX  179 179 ALA D 1253  ALA D 1256  5                                   4    
HELIX  180 180 GLU D 1262  LEU D 1267  5                                   6    
HELIX  181 181 ALA D 1268  THR D 1287  1                                  20    
HELIX  182 182 THR D 1302  ALA D 1309  1                                   8    
HELIX  183 183 PHE D 1314  CYS D 1318  5                                   5    
SHEET    1  AA 5 ARG A  13  GLU A  17  0                                        
SHEET    2  AA 5 LEU A   6  VAL A  10 -1  O  LEU A   6   N  GLU A  17           
SHEET    3  AA 5 ALA A  84  THR A  86  1  N  VAL A  85   O  PHE A   9           
SHEET    4  AA 5 THR A  52  TYR A  58 -1  O  MET A  54   N  THR A  86           
SHEET    5  AA 5 ILE A  65  ASN A  71 -1  O  VAL A  66   N  LYS A  57           
SHEET    1  AB 4 LEU A 227  GLU A 230  0                                        
SHEET    2  AB 4 THR A 235  GLN A 238 -1  O  TRP A 236   N  PHE A 229           
SHEET    3  AB 4 MET A 277  CYS A 280  1  O  ILE A 278   N  ILE A 237           
SHEET    4  AB 4 LYS A 256  LEU A 257  1  O  LYS A 256   N  VAL A 279           
SHEET    1  AC 4 VAL A 290  HIS A 292  0                                        
SHEET    2  AC 4 GLY A 296  GLY A 300 -1  O  SER A 298   N  GLU A 291           
SHEET    3  AC 4 ILE A 403  PRO A 410 -1  O  ILE A 407   N  PHE A 299           
SHEET    4  AC 4 THR A 373  VAL A 375 -1  O  THR A 373   N  LEU A 405           
SHEET    1  AD 4 GLU A 416  GLN A 423  0                                        
SHEET    2  AD 4 VAL A 434  LEU A 441 -1  O  VAL A 434   N  GLN A 423           
SHEET    3  AD 4 GLU A 451  GLY A 457 -1  O  GLU A 451   N  LEU A 441           
SHEET    4  AD 4 ILE A 464  SER A 465 -1  O  ILE A 464   N  TYR A 456           
SHEET    1  AE 5 GLN A 559  LEU A 560  0                                        
SHEET    2  AE 5 GLU A1239  LEU A1244  1  O  VAL A1242   N  LEU A 560           
SHEET    3  AE 5 ASP A1171  ASP A1182  1  O  LEU A1175   N  GLU A1239           
SHEET    4  AE 5 TYR A1153  ASP A1166 -1  O  TYR A1156   N  ASP A1182           
SHEET    5  AE 5 LYS A 995  ILE A1008 -1  O  LYS A 996   N  ILE A1165           
SHEET    1  AF 6 LEU A 604  SER A 605  0                                        
SHEET    2  AF 6 VAL A 824  MET A 827  1  N  ARG A 825   O  LEU A 604           
SHEET    3  AF 6 CYS A 749  VAL A 753 -1  O  THR A 750   N  CYS A 826           
SHEET    4  AF 6 MET A 761  VAL A 765 -1  O  GLU A 762   N  VAL A 753           
SHEET    5  AF 6 ILE A 788  VAL A 792  1  O  VAL A 789   N  LEU A 763           
SHEET    6  AF 6 THR A1067  SER A1068 -1  O  THR A1067   N  VAL A 792           
SHEET    1  AG 3 LEU A 608  THR A 610  0                                        
SHEET    2  AG 3 ILE A 667  ALA A 673 -1  N  ILE A 668   O  VAL A 609           
SHEET    3  AG 3 PHE A 632  SER A 637 -1  N  VAL A 633   O  VAL A 672           
SHEET    1  AH 3 LYS A 660  VAL A 661  0                                        
SHEET    2  AH 3 ALA A 616  ASP A 622 -1  O  ALA A 616   N  VAL A 661           
SHEET    3  AH 3 LYS A 687  GLU A 691 -1  O  LYS A 687   N  ASP A 622           
SHEET    1  AI 5 LEU A 713  LYS A 717  0                                        
SHEET    2  AI 5 ILE A 895  LYS A 903 -1  O  ILE A 895   N  LYS A 717           
SHEET    3  AI 5 VAL A 857  GLY A 869  1  O  LEU A 860   N  ARG A 896           
SHEET    4  AI 5 PHE A 843  PHE A 851 -1  O  LEU A 844   N  PHE A 865           
SHEET    5  AI 5 ASN A 729  ILE A 737 -1  O  ASN A 729   N  PHE A 851           
SHEET    1  AJ 4 ILE A1062  ILE A1064  0                                        
SHEET    2  AJ 4 VAL A1030  HIS A1034  1  O  VAL A1030   N  TYR A1063           
SHEET    3  AJ 4 GLN A1017  VAL A1024 -1  O  LEU A1021   N  THR A1033           
SHEET    4  AJ 4 SER A1129  ARG A1135 -1  O  ALA A1130   N  LEU A1022           
SHEET    1  AK 2 GLY A1140  SER A1142  0                                        
SHEET    2  AK 2 SER A1147  ASN A1149 -1  O  SER A1147   N  SER A1142           
SHEET    1  BA 5 ARG B  13  GLU B  17  0                                        
SHEET    2  BA 5 LEU B   6  VAL B  10 -1  O  LEU B   6   N  GLU B  17           
SHEET    3  BA 5 ALA B  84  THR B  86  1  N  VAL B  85   O  PHE B   9           
SHEET    4  BA 5 THR B  52  TYR B  58 -1  O  MET B  54   N  THR B  86           
SHEET    5  BA 5 ILE B  65  ASN B  71 -1  O  VAL B  66   N  LYS B  57           
SHEET    1  BB 4 LEU B 227  GLU B 230  0                                        
SHEET    2  BB 4 THR B 235  GLN B 238 -1  O  TRP B 236   N  PHE B 229           
SHEET    3  BB 4 MET B 277  CYS B 280  1  O  ILE B 278   N  ILE B 237           
SHEET    4  BB 4 LYS B 256  LEU B 257  1  O  LYS B 256   N  VAL B 279           
SHEET    1  BC 4 VAL B 290  HIS B 292  0                                        
SHEET    2  BC 4 GLY B 296  GLY B 300 -1  O  SER B 298   N  GLU B 291           
SHEET    3  BC 4 ILE B 403  PRO B 410 -1  O  ILE B 407   N  PHE B 299           
SHEET    4  BC 4 THR B 373  VAL B 375 -1  O  THR B 373   N  LEU B 405           
SHEET    1  BD 4 GLU B 416  GLN B 423  0                                        
SHEET    2  BD 4 VAL B 434  LEU B 441 -1  O  VAL B 434   N  GLN B 423           
SHEET    3  BD 4 GLU B 451  GLY B 457 -1  O  GLU B 451   N  LEU B 441           
SHEET    4  BD 4 ILE B 464  SER B 465 -1  O  ILE B 464   N  TYR B 456           
SHEET    1  BE 5 GLN B 559  LEU B 560  0                                        
SHEET    2  BE 5 GLU B1239  LEU B1244  1  O  VAL B1242   N  LEU B 560           
SHEET    3  BE 5 HIS B1172  MET B1181  1  O  LEU B1175   N  GLU B1239           
SHEET    4  BE 5 TYR B1153  ASP B1166 -1  O  VAL B1158   N  VAL B1180           
SHEET    5  BE 5 LYS B 995  ILE B1008 -1  O  LYS B 996   N  ILE B1165           
SHEET    1  BF 6 LEU B 604  SER B 605  0                                        
SHEET    2  BF 6 VAL B 824  MET B 827  1  N  ARG B 825   O  LEU B 604           
SHEET    3  BF 6 CYS B 749  PRO B 754 -1  O  THR B 750   N  CYS B 826           
SHEET    4  BF 6 MET B 761  VAL B 765 -1  O  GLU B 762   N  VAL B 753           
SHEET    5  BF 6 ILE B 788  VAL B 792  1  O  VAL B 789   N  LEU B 763           
SHEET    6  BF 6 THR B1067  SER B1068 -1  O  THR B1067   N  VAL B 792           
SHEET    1  BG 3 LEU B 608  THR B 610  0                                        
SHEET    2  BG 3 ILE B 667  VAL B 672 -1  N  ILE B 668   O  VAL B 609           
SHEET    3  BG 3 CYS B 634  SER B 637 -1  O  CYS B 634   N  VAL B 672           
SHEET    1  BH 3 LYS B 660  VAL B 661  0                                        
SHEET    2  BH 3 ALA B 616  ASP B 622 -1  O  ALA B 616   N  VAL B 661           
SHEET    3  BH 3 LYS B 687  GLU B 691 -1  O  LYS B 687   N  ASP B 622           
SHEET    1  BI 5 LEU B 713  LYS B 717  0                                        
SHEET    2  BI 5 ILE B 895  LYS B 903 -1  O  ILE B 895   N  LYS B 717           
SHEET    3  BI 5 VAL B 857  GLY B 869  1  O  LEU B 860   N  ARG B 896           
SHEET    4  BI 5 PHE B 843  PHE B 851 -1  O  LEU B 844   N  PHE B 865           
SHEET    5  BI 5 ASN B 729  ILE B 737 -1  O  ASN B 729   N  PHE B 851           
SHEET    1  BJ 4 ILE B1062  ILE B1064  0                                        
SHEET    2  BJ 4 VAL B1030  HIS B1034  1  O  VAL B1030   N  TYR B1063           
SHEET    3  BJ 4 GLN B1017  VAL B1024 -1  O  LEU B1021   N  THR B1033           
SHEET    4  BJ 4 SER B1129  ARG B1135 -1  O  ALA B1130   N  LEU B1022           
SHEET    1  BK 2 GLY B1140  SER B1142  0                                        
SHEET    2  BK 2 SER B1147  ASN B1149 -1  O  SER B1147   N  SER B1142           
SHEET    1  CA 5 ARG C  13  GLU C  17  0                                        
SHEET    2  CA 5 LEU C   6  VAL C  10 -1  O  LEU C   6   N  GLU C  17           
SHEET    3  CA 5 ALA C  84  THR C  86  1  N  VAL C  85   O  PHE C   9           
SHEET    4  CA 5 THR C  52  TYR C  58 -1  O  MET C  54   N  THR C  86           
SHEET    5  CA 5 ILE C  65  ASN C  71 -1  O  VAL C  66   N  LYS C  57           
SHEET    1  CB 4 LEU C 227  GLU C 230  0                                        
SHEET    2  CB 4 THR C 235  GLN C 238 -1  O  TRP C 236   N  PHE C 229           
SHEET    3  CB 4 MET C 277  CYS C 280  1  O  ILE C 278   N  ILE C 237           
SHEET    4  CB 4 LYS C 256  LEU C 257  1  O  LYS C 256   N  VAL C 279           
SHEET    1  CC 4 VAL C 290  HIS C 292  0                                        
SHEET    2  CC 4 GLY C 296  GLY C 300 -1  O  SER C 298   N  GLU C 291           
SHEET    3  CC 4 ILE C 403  PRO C 410 -1  O  ILE C 407   N  PHE C 299           
SHEET    4  CC 4 THR C 373  VAL C 375 -1  O  THR C 373   N  LEU C 405           
SHEET    1  CD 4 GLU C 416  GLN C 423  0                                        
SHEET    2  CD 4 VAL C 434  LEU C 441 -1  O  VAL C 434   N  GLN C 423           
SHEET    3  CD 4 GLU C 451  GLY C 457 -1  O  GLU C 451   N  LEU C 441           
SHEET    4  CD 4 ILE C 464  SER C 465 -1  O  ILE C 464   N  TYR C 456           
SHEET    1  CE 5 GLN C 559  LEU C 560  0                                        
SHEET    2  CE 5 GLU C1239  LEU C1244  1  O  VAL C1242   N  LEU C 560           
SHEET    3  CE 5 HIS C1172  MET C1181  1  O  LEU C1175   N  GLU C1239           
SHEET    4  CE 5 TYR C1153  ASP C1166 -1  O  VAL C1158   N  VAL C1180           
SHEET    5  CE 5 LYS C 995  ILE C1008 -1  O  LYS C 996   N  ILE C1165           
SHEET    1  CF 6 LEU C 604  SER C 605  0                                        
SHEET    2  CF 6 VAL C 824  MET C 827  1  N  ARG C 825   O  LEU C 604           
SHEET    3  CF 6 CYS C 749  VAL C 753 -1  O  THR C 750   N  CYS C 826           
SHEET    4  CF 6 MET C 761  VAL C 765 -1  O  GLU C 762   N  VAL C 753           
SHEET    5  CF 6 ILE C 788  VAL C 792  1  O  VAL C 789   N  LEU C 763           
SHEET    6  CF 6 THR C1067  SER C1068 -1  O  THR C1067   N  VAL C 792           
SHEET    1  CG 3 LEU C 608  THR C 610  0                                        
SHEET    2  CG 3 ILE C 667  ALA C 673 -1  N  ILE C 668   O  VAL C 609           
SHEET    3  CG 3 PHE C 632  SER C 637 -1  N  VAL C 633   O  VAL C 672           
SHEET    1  CH 3 LYS C 660  VAL C 661  0                                        
SHEET    2  CH 3 ALA C 616  ASP C 622 -1  O  ALA C 616   N  VAL C 661           
SHEET    3  CH 3 LYS C 687  GLU C 691 -1  O  LYS C 687   N  ASP C 622           
SHEET    1  CI 5 LEU C 713  LYS C 717  0                                        
SHEET    2  CI 5 ILE C 895  LYS C 903 -1  O  ILE C 895   N  LYS C 717           
SHEET    3  CI 5 VAL C 857  GLY C 869  1  O  LEU C 860   N  ARG C 896           
SHEET    4  CI 5 PHE C 843  PHE C 851 -1  O  LEU C 844   N  PHE C 865           
SHEET    5  CI 5 ASN C 729  ILE C 737 -1  O  ASN C 729   N  PHE C 851           
SHEET    1  CJ 4 ILE C1062  ILE C1064  0                                        
SHEET    2  CJ 4 VAL C1030  HIS C1034  1  O  VAL C1030   N  TYR C1063           
SHEET    3  CJ 4 GLN C1017  VAL C1024 -1  O  LEU C1021   N  THR C1033           
SHEET    4  CJ 4 SER C1129  ARG C1135 -1  O  ALA C1130   N  LEU C1022           
SHEET    1  CK 2 GLY C1140  SER C1142  0                                        
SHEET    2  CK 2 SER C1147  ASN C1149 -1  O  SER C1147   N  SER C1142           
SHEET    1  DA 5 ARG D  13  GLU D  17  0                                        
SHEET    2  DA 5 LEU D   6  VAL D  10 -1  O  LEU D   6   N  GLU D  17           
SHEET    3  DA 5 ALA D  84  THR D  86  1  N  VAL D  85   O  PHE D   9           
SHEET    4  DA 5 THR D  52  TYR D  58 -1  O  MET D  54   N  THR D  86           
SHEET    5  DA 5 ILE D  65  ASN D  71 -1  O  VAL D  66   N  LYS D  57           
SHEET    1  DB 4 LEU D 227  GLU D 230  0                                        
SHEET    2  DB 4 THR D 235  GLN D 238 -1  O  TRP D 236   N  PHE D 229           
SHEET    3  DB 4 MET D 277  CYS D 280  1  O  ILE D 278   N  ILE D 237           
SHEET    4  DB 4 LYS D 256  LEU D 257  1  O  LYS D 256   N  VAL D 279           
SHEET    1  DC 4 VAL D 290  HIS D 292  0                                        
SHEET    2  DC 4 GLY D 296  GLY D 300 -1  O  SER D 298   N  GLU D 291           
SHEET    3  DC 4 ILE D 403  PRO D 410 -1  O  ILE D 407   N  PHE D 299           
SHEET    4  DC 4 THR D 373  VAL D 375 -1  O  THR D 373   N  LEU D 405           
SHEET    1  DD 4 GLU D 416  GLN D 423  0                                        
SHEET    2  DD 4 VAL D 434  LEU D 441 -1  O  VAL D 434   N  GLN D 423           
SHEET    3  DD 4 GLU D 451  GLY D 457 -1  O  GLU D 451   N  LEU D 441           
SHEET    4  DD 4 ILE D 464  SER D 465 -1  O  ILE D 464   N  TYR D 456           
SHEET    1  DE 5 GLN D 559  LEU D 560  0                                        
SHEET    2  DE 5 GLU D1239  SER D1243  1  O  VAL D1242   N  LEU D 560           
SHEET    3  DE 5 HIS D1172  ASP D1182  1  O  LEU D1175   N  GLU D1239           
SHEET    4  DE 5 TYR D1153  ASP D1166 -1  O  TYR D1156   N  ASP D1182           
SHEET    5  DE 5 LYS D 995  ILE D1008 -1  O  LYS D 996   N  ILE D1165           
SHEET    1  DF 6 LEU D 604  SER D 605  0                                        
SHEET    2  DF 6 VAL D 824  MET D 827  1  N  ARG D 825   O  LEU D 604           
SHEET    3  DF 6 CYS D 749  PRO D 754 -1  O  THR D 750   N  CYS D 826           
SHEET    4  DF 6 MET D 761  VAL D 765 -1  O  GLU D 762   N  VAL D 753           
SHEET    5  DF 6 ILE D 788  VAL D 792  1  O  VAL D 789   N  LEU D 763           
SHEET    6  DF 6 THR D1067  SER D1068 -1  O  THR D1067   N  VAL D 792           
SHEET    1  DG 3 LEU D 608  THR D 610  0                                        
SHEET    2  DG 3 ILE D 667  VAL D 672 -1  N  ILE D 668   O  VAL D 609           
SHEET    3  DG 3 CYS D 634  SER D 637 -1  O  CYS D 634   N  VAL D 672           
SHEET    1  DH 3 LYS D 660  VAL D 661  0                                        
SHEET    2  DH 3 ALA D 616  ASP D 622 -1  O  ALA D 616   N  VAL D 661           
SHEET    3  DH 3 LYS D 687  GLU D 691 -1  O  LYS D 687   N  ASP D 622           
SHEET    1  DI 5 LEU D 713  LYS D 717  0                                        
SHEET    2  DI 5 ILE D 895  LYS D 903 -1  O  ILE D 895   N  LYS D 717           
SHEET    3  DI 5 VAL D 857  GLY D 869  1  O  LEU D 860   N  ARG D 896           
SHEET    4  DI 5 PHE D 843  PHE D 851 -1  O  LEU D 844   N  PHE D 865           
SHEET    5  DI 5 ASN D 729  ILE D 737 -1  O  ASN D 729   N  PHE D 851           
SHEET    1  DJ 4 ILE D1062  TYR D1063  0                                        
SHEET    2  DJ 4 VAL D1030  HIS D1034  1  O  VAL D1030   N  TYR D1063           
SHEET    3  DJ 4 GLN D1017  VAL D1024 -1  O  LEU D1021   N  THR D1033           
SHEET    4  DJ 4 SER D1129  ARG D1135 -1  O  ALA D1130   N  LEU D1022           
SHEET    1  DK 2 GLY D1140  SER D1142  0                                        
SHEET    2  DK 2 SER D1147  ASN D1149 -1  O  SER D1147   N  SER D1142           
SSBOND   1 CYS A  509    CYS A 1318                          1555   1555  2.16  
SSBOND   2 CYS B  509    CYS B 1318                          1555   1555  2.20  
SSBOND   3 CYS B  536    CYS B  993                          1555   1555  2.08  
SSBOND   4 CYS C  509    CYS C 1318                          1555   1555  2.08  
SSBOND   5 CYS C  536    CYS C  993                          1555   1555  2.11  
SSBOND   6 CYS D  509    CYS D 1318                          1555   1555  2.24  
SSBOND   7 CYS D  536    CYS D  993                          1555   1555  2.14  
LINK        FE1  FES A3001                 SG  CYS A 148     1555   1555  2.29  
LINK        FE1  FES A3001                 SG  CYS A 116     1555   1555  2.38  
LINK        FE2  FES A3001                 SG  CYS A 113     1555   1555  2.11  
LINK        FE2  FES A3001                 SG  CYS A 150     1555   1555  2.53  
LINK        FE1  FES A3002                 SG  CYS A  48     1555   1555  2.35  
LINK        FE1  FES A3002                 SG  CYS A  43     1555   1555  2.31  
LINK        FE2  FES A3002                 SG  CYS A  51     1555   1555  2.34  
LINK        FE2  FES A3002                 SG  CYS A  73     1555   1555  2.44  
LINK        FE1  FES B3001                 SG  CYS B 116     1555   1555  2.30  
LINK        FE1  FES B3001                 SG  CYS B 148     1555   1555  2.36  
LINK        FE2  FES B3001                 SG  CYS B 150     1555   1555  2.58  
LINK        FE2  FES B3001                 SG  CYS B 113     1555   1555  2.30  
LINK        FE1  FES B3002                 SG  CYS B  43     1555   1555  2.11  
LINK        FE1  FES B3002                 SG  CYS B  48     1555   1555  2.36  
LINK        FE2  FES B3002                 SG  CYS B  51     1555   1555  2.34  
LINK        FE2  FES B3002                 SG  CYS B  73     1555   1555  2.46  
LINK        FE1  FES C3001                 SG  CYS C 148     1555   1555  2.40  
LINK        FE2  FES C3001                 SG  CYS C 113     1555   1555  2.38  
LINK        FE2  FES C3001                 SG  CYS C 150     1555   1555  2.73  
LINK        FE1  FES C3001                 SG  CYS C 116     1555   1555  2.22  
LINK        FE1  FES C3002                 SG  CYS C  43     1555   1555  2.29  
LINK        FE2  FES C3002                 SG  CYS C  51     1555   1555  2.19  
LINK        FE2  FES C3002                 SG  CYS C  73     1555   1555  2.43  
LINK        FE1  FES C3002                 SG  CYS C  48     1555   1555  2.38  
LINK        FE1  FES D3001                 SG  CYS D 116     1555   1555  2.41  
LINK        FE2  FES D3001                 SG  CYS D 113     1555   1555  2.23  
LINK        FE2  FES D3001                 SG  CYS D 150     1555   1555  2.83  
LINK        FE1  FES D3001                 SG  CYS D 148     1555   1555  2.31  
LINK        FE1  FES D3002                 SG  CYS D  48     1555   1555  2.46  
LINK        FE2  FES D3002                 SG  CYS D  51     1555   1555  2.18  
LINK        FE2  FES D3002                 SG  CYS D  73     1555   1555  2.30  
LINK        FE1  FES D3002                 SG  CYS D  43     1555   1555  2.26  
SITE     1 AC1  6 GLN D1041  ALA D1079  SER D1081  SER D1083                    
SITE     2 AC1  6 GLY D1261  ACY D3008                                          
SITE     1 AC2  6 CYS A 113  GLY A 114  CYS A 116  CYS A 148                    
SITE     2 AC2  6 ARG A 149  CYS A 150                                          
SITE     1 AC3  8 GLY A  42  CYS A  43  GLY A  44  GLY A  46                    
SITE     2 AC3  8 CYS A  48  GLY A  49  CYS A  51  CYS A  73                    
SITE     1 AC4 23 GLY A  46  LYS A 256  LEU A 257  VAL A 258                    
SITE     2 AC4 23 VAL A 259  GLY A 260  ASN A 261  THR A 262                    
SITE     3 AC4 23 GLU A 263  ILE A 264  PHE A 337  ALA A 338                    
SITE     4 AC4 23 ALA A 346  SER A 347  GLY A 350  ASN A 351                    
SITE     5 AC4 23 ILE A 353  THR A 354  SER A 359  ASP A 360                    
SITE     6 AC4 23 ILE A 403  LEU A 404  LYS A 422                               
SITE     1 AC5  7 GLN B 112  CYS B 113  GLY B 114  CYS B 116                    
SITE     2 AC5  7 CYS B 148  ARG B 149  CYS B 150                               
SITE     1 AC6  8 GLY B  42  CYS B  43  GLY B  44  GLY B  46                    
SITE     2 AC6  8 CYS B  48  GLY B  49  CYS B  51  CYS B  73                    
SITE     1 AC7 20 LYS B 256  LEU B 257  VAL B 259  GLY B 260                    
SITE     2 AC7 20 ASN B 261  THR B 262  GLU B 263  ILE B 264                    
SITE     3 AC7 20 PHE B 337  ALA B 338  ALA B 346  SER B 347                    
SITE     4 AC7 20 GLY B 350  ASN B 351  ILE B 353  THR B 354                    
SITE     5 AC7 20 SER B 359  ASP B 360  LEU B 404  LYS B 422                    
SITE     1 AC8  7 GLN C 112  CYS C 113  GLY C 114  CYS C 116                    
SITE     2 AC8  7 CYS C 148  ARG C 149  CYS C 150                               
SITE     1 AC9  8 GLY C  42  CYS C  43  GLY C  44  GLY C  46                    
SITE     2 AC9  8 CYS C  48  GLY C  49  CYS C  51  CYS C  73                    
SITE     1 BC1 22 GLY C  46  LYS C 256  LEU C 257  VAL C 259                    
SITE     2 BC1 22 GLY C 260  ASN C 261  THR C 262  GLU C 263                    
SITE     3 BC1 22 ILE C 264  ALA C 301  PHE C 337  ALA C 338                    
SITE     4 BC1 22 ALA C 346  SER C 347  GLY C 350  ASN C 351                    
SITE     5 BC1 22 ILE C 353  SER C 359  ASP C 360  ILE C 403                    
SITE     6 BC1 22 LEU C 404  LYS C 422                                          
SITE     1 BC2  6 CYS D 113  GLY D 114  CYS D 116  CYS D 148                    
SITE     2 BC2  6 ARG D 149  CYS D 150                                          
SITE     1 BC3  8 GLY D  42  CYS D  43  GLY D  44  GLY D  46                    
SITE     2 BC3  8 CYS D  48  GLY D  49  CYS D  51  CYS D  73                    
SITE     1 BC4 24 GLY D  46  LYS D 256  LEU D 257  VAL D 258                    
SITE     2 BC4 24 VAL D 259  GLY D 260  ASN D 261  THR D 262                    
SITE     3 BC4 24 GLU D 263  ILE D 264  ALA D 301  PHE D 337                    
SITE     4 BC4 24 ALA D 346  SER D 347  GLY D 350  ASN D 351                    
SITE     5 BC4 24 ILE D 353  THR D 354  SER D 359  ASP D 360                    
SITE     6 BC4 24 ILE D 403  LEU D 404  LYS D 422  ASP D 430                    
SITE     1 BC5  9 ARG A 840  HIS A 841  ILE A 878  THR A 910                    
SITE     2 BC5  9 ALA A 911  PHE A 912  PHE A 915  GLY A 916                    
SITE     3 BC5  9 GLN A 919                                                     
SITE     1 BC6  8 ARG B 840  HIS B 841  ILE B 878  THR B 910                    
SITE     2 BC6  8 PHE B 912  PHE B 915  GLY B 916  GLN B 919                    
SITE     1 BC7  9 ARG C 840  HIS C 841  ILE C 878  THR C 910                    
SITE     2 BC7  9 ALA C 911  PHE C 912  PHE C 915  GLY C 916                    
SITE     3 BC7  9 GLN C 919                                                     
SITE     1 BC8  9 ARG D 840  HIS D 841  ILE D 878  THR D 910                    
SITE     2 BC8  9 ALA D 911  PHE D 912  PHE D 915  GLY D 916                    
SITE     3 BC8  9 GLN D 919                                                     
SITE     1 BC9  2 ALA D1079  PO4 D3009                                          
CRYST1  197.734  197.734  285.538  90.00  90.00 120.00 P 31 2 1     24          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.005057  0.002920  0.000000        0.00000                         
SCALE2      0.000000  0.005840  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.003502        0.00000                         
MTRIX1   1 -0.507000 -0.862000 -0.006000       97.69203    1                    
MTRIX2   1 -0.862000  0.507000 -0.023000      173.79907    1                    
MTRIX3   1  0.023000 -0.007000 -1.000000      237.25742    1                    
MTRIX1   2  0.462000 -0.886000  0.029000       39.08794    1                    
MTRIX2   2  0.887000  0.463000  0.009000      -63.10650    1                    
MTRIX3   2 -0.021000  0.022000  1.000000      -25.20313    1                    
MTRIX1   3 -0.999000 -0.033000 -0.032000       46.84574    1                    
MTRIX2   3 -0.033000  0.999000 -0.002000      -62.02838    1                    
MTRIX3   3  0.032000 -0.001000 -0.999000      259.46573    1                    
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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