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Database: PDB
Entry: 2ECD
LinkDB: 2ECD
Original site: 2ECD 
HEADER    SIGNALING PROTEIN                       13-FEB-07   2ECD              
TITLE     SOLUTION STRUCTURE OF THE HUMAN ABL2 SH2 DOMAIN                       
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: TYROSINE-PROTEIN KINASE ABL2;                              
COMPND   3 CHAIN: A;                                                            
COMPND   4 FRAGMENT: SH2 DOMAIN;                                                
COMPND   5 SYNONYM: ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 2,           
COMPND   6 ABELSON-RELATED GENE PROTEIN, TYROSINE KINASE ARG;                   
COMPND   7 EC: 2.7.10.2;                                                        
COMPND   8 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: ABL2;                                                          
SOURCE   6 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE   7 EXPRESSION_SYSTEM_PLASMID: P040705-09;                               
SOURCE   8 OTHER_DETAILS: CELL-FREE PROTEIN SYNTHESIS                           
KEYWDS    SH2 DOMAIN, PHOSPHOTYROSINE BINDING DOMAIN, PROTEIN                   
KEYWDS   2 TYROSINE KINASE, SIGNAL TRANSDUCTION, STRUCTURAL GENOMICS,           
KEYWDS   3 NPPSFA, NATIONAL PROJECT ON PROTEIN STRUCTURAL AND                   
KEYWDS   4 FUNCTIONAL ANALYSES, RIKEN STRUCTURAL GENOMICS/PROTEOMICS            
KEYWDS   5 INITIATIVE, RSGI, SIGNALING PROTEIN                                  
EXPDTA    SOLUTION NMR                                                          
NUMMDL    20                                                                    
AUTHOR    T.KASAI,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMA,RIKEN                   
AUTHOR   2 STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE (RSGI)                     
REVDAT   2   24-FEB-09 2ECD    1       VERSN                                    
REVDAT   1   19-FEB-08 2ECD    0                                                
JRNL        AUTH   T.KASAI,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMA                
JRNL        TITL   SOLUTION STRUCTURE OF THE HUMAN ABL2 SH2 DOMAIN              
JRNL        REF    TO BE PUBLISHED                                              
JRNL        REFN                                                                
REMARK   1                                                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION. NOT APPLICABLE.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : CYANA 2.0.17                                         
REMARK   3   AUTHORS     : GUNTERT, P.                                          
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 2ECD COMPLIES WITH FORMAT V. 3.15, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 15-FEB-07.                  
REMARK 100 THE RCSB ID CODE IS RCSB026493.                                      
REMARK 210                                                                      
REMARK 210 EXPERIMENTAL DETAILS                                                 
REMARK 210  EXPERIMENT TYPE                : NMR                                
REMARK 210  TEMPERATURE           (KELVIN) : 298                                
REMARK 210  PH                             : 7.0                                
REMARK 210  IONIC STRENGTH                 : 120MM                              
REMARK 210  PRESSURE                       : AMBIENT                            
REMARK 210  SAMPLE CONTENTS                : 0.33MM SH2 DOMAIN U-15N, 13C;      
REMARK 210                                   20MM D-TRIS-HCL(PH 7.0); 100MM     
REMARK 210                                   NACL; 1MM D-DTT; 0.02% NAN3;       
REMARK 210                                   90% H2O, 10% D2O                   
REMARK 210                                                                      
REMARK 210  NMR EXPERIMENTS CONDUCTED      : 3D_15N-SEPARATED_NOESY, 3D_        
REMARK 210                                   13C-SEPARATED_NOESY                
REMARK 210  SPECTROMETER FIELD STRENGTH    : 800 MHZ                            
REMARK 210  SPECTROMETER MODEL             : AVANCE                             
REMARK 210  SPECTROMETER MANUFACTURER      : BRUKER                             
REMARK 210                                                                      
REMARK 210  STRUCTURE DETERMINATION.                                            
REMARK 210   SOFTWARE USED                 : XWINNMR 3.5, NMRPIPE               
REMARK 210                                   20031121, NMRVIEW 5.0.4,           
REMARK 210                                   KUJIRA 0.9810, CYANA 2.0.17        
REMARK 210   METHOD USED                   : TORSION ANGLE DYNAMICS,            
REMARK 210                                   RESTRAINTED MOLECULAR DYNAMICS     
REMARK 210                                                                      
REMARK 210 CONFORMERS, NUMBER CALCULATED   : 100                                
REMARK 210 CONFORMERS, NUMBER SUBMITTED    : 20                                 
REMARK 210 CONFORMERS, SELECTION CRITERIA  : STRUCTURES WITH THE LEAST          
REMARK 210                                   RESTRAINT VIOLATIONS,              
REMARK 210                                   STRUCTURES WITH THE LOWEST         
REMARK 210                                   ENERGY, TARGET FUNCTION            
REMARK 210                                                                      
REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : 1                   
REMARK 210                                                                      
REMARK 210 REMARK: NULL                                                         
REMARK 215                                                                      
REMARK 215 NMR STUDY                                                            
REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION           
REMARK 215 NMR DATA.  PROTEIN DATA BANK CONVENTIONS REQUIRE THAT                
REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON              
REMARK 215 THESE RECORDS ARE MEANINGLESS.                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500  1 SER A   5      110.43   -172.29                                   
REMARK 500  1 LYS A  15      -62.16    -90.86                                   
REMARK 500  1 HIS A  16      142.44    -34.51                                   
REMARK 500  1 SER A  34       35.05    -90.67                                   
REMARK 500  1 ASN A  37       43.65    -84.66                                   
REMARK 500  1 SER A  47      -70.99    -40.62                                   
REMARK 500  1 VAL A  77       74.98   -106.35                                   
REMARK 500  1 LEU A 100      173.05    -48.45                                   
REMARK 500  1 LEU A 104      101.57    -47.02                                   
REMARK 500  1 LYS A 110       47.01     31.92                                   
REMARK 500  1 SER A 118      135.92   -171.81                                   
REMARK 500  2 ASN A  11      132.66   -170.43                                   
REMARK 500  2 HIS A  20       40.65   -107.20                                   
REMARK 500  2 SER A  34       34.44    -87.68                                   
REMARK 500  2 ILE A  36      177.36    -52.34                                   
REMARK 500  2 ASN A  37       44.51    -85.25                                   
REMARK 500  2 PRO A  49       86.98    -69.82                                   
REMARK 500  2 TYR A  76      122.03   -171.32                                   
REMARK 500  2 LEU A 100     -178.83    -53.03                                   
REMARK 500  2 PRO A 107     -164.63    -69.77                                   
REMARK 500  3 VAL A  10       36.31     37.76                                   
REMARK 500  3 LEU A  13       43.19    -86.68                                   
REMARK 500  3 GLU A  14       48.02    -75.73                                   
REMARK 500  3 HIS A  20      -51.83   -124.18                                   
REMARK 500  3 PRO A  22       86.64    -69.65                                   
REMARK 500  3 LEU A  35      173.64    -59.42                                   
REMARK 500  3 GLU A  46      -70.46    -85.40                                   
REMARK 500  3 SER A  48      162.78    -41.48                                   
REMARK 500  3 PRO A  49     -162.91    -69.80                                   
REMARK 500  3 GLU A  59       96.78    -38.45                                   
REMARK 500  3 THR A  78      148.72   -176.65                                   
REMARK 500  3 HIS A  93       33.67    -83.98                                   
REMARK 500  3 ASP A  98       83.01    -54.82                                   
REMARK 500  4 ASN A  11      140.64    -35.63                                   
REMARK 500  4 LEU A  13       57.50   -112.14                                   
REMARK 500  4 TYR A  19       88.73    -68.23                                   
REMARK 500  4 PRO A  22       82.86    -69.70                                   
REMARK 500  4 LEU A  35     -178.60    -59.71                                   
REMARK 500  4 PRO A  49        8.96    -69.87                                   
REMARK 500  4 TYR A  76      122.45   -173.06                                   
REMARK 500  4 VAL A  77       76.16   -105.51                                   
REMARK 500  4 VAL A 101      -36.78    -33.82                                   
REMARK 500  4 THR A 102      149.64   -173.76                                   
REMARK 500  4 PRO A 107     -177.42    -69.84                                   
REMARK 500  4 SER A 117      123.36    -36.26                                   
REMARK 500  5 SER A  12       96.19    -51.35                                   
REMARK 500  5 GLU A  14       83.03    -55.93                                   
REMARK 500  5 PRO A  22       93.90    -69.78                                   
REMARK 500  5 ILE A  36      162.09    -49.20                                   
REMARK 500  5 PRO A  49       87.58    -69.80                                   
REMARK 500  5 GLU A  59       41.76     35.82                                   
REMARK 500  5 ALA A  71      142.81    -36.19                                   
REMARK 500  5 TYR A  76      121.37   -174.49                                   
REMARK 500  5 VAL A  77       76.36   -101.28                                   
REMARK 500  5 LEU A 104      101.12    -35.91                                   
REMARK 500  5 HIS A 105      -71.07    -72.99                                   
REMARK 500  5 PRO A 107     -177.35    -69.83                                   
REMARK 500  6 SER A   3      142.35    -35.61                                   
REMARK 500  6 SER A   5      129.87   -171.80                                   
REMARK 500  6 GLU A  14       41.16    -96.50                                   
REMARK 500  6 PRO A  22       89.78    -69.77                                   
REMARK 500  6 LEU A  35      176.76    -53.96                                   
REMARK 500  6 ASN A  37       39.79    -83.34                                   
REMARK 500  6 TYR A  65      105.40   -160.84                                   
REMARK 500  6 TYR A  76      120.18   -172.38                                   
REMARK 500  6 ASP A  98       93.15    -37.46                                   
REMARK 500  6 LEU A 104       92.91    -38.39                                   
REMARK 500  6 PRO A 107     -178.95    -69.72                                   
REMARK 500  6 LYS A 110      161.55    -40.47                                   
REMARK 500  6 CYS A 111      -51.98   -120.62                                   
REMARK 500  6 SER A 114      123.03   -171.81                                   
REMARK 500  7 SER A   6      146.52   -174.99                                   
REMARK 500  7 GLU A  14       38.09     33.24                                   
REMARK 500  7 PRO A  22       85.52    -69.71                                   
REMARK 500  7 ILE A  36     -178.41    -69.42                                   
REMARK 500  7 ASN A  37       39.48    -93.29                                   
REMARK 500  7 SER A  45      142.11    -39.20                                   
REMARK 500  7 GLU A  59       95.49    -38.08                                   
REMARK 500  7 TYR A  76      120.75   -174.74                                   
REMARK 500  7 SER A  84      -63.08    -91.45                                   
REMARK 500  7 THR A 102      143.94   -174.69                                   
REMARK 500  7 THR A 103      158.53    -43.18                                   
REMARK 500  7 HIS A 105      -66.07   -106.12                                   
REMARK 500  7 ALA A 108      139.35   -175.16                                   
REMARK 500  7 PRO A 109     -173.85    -69.68                                   
REMARK 500  7 LYS A 110       70.67   -119.25                                   
REMARK 500  7 SER A 118      123.26    -36.34                                   
REMARK 500  8 SER A   2      130.93    -39.42                                   
REMARK 500  8 LYS A  15      -37.65    -34.40                                   
REMARK 500  8 HIS A  16      164.93    -45.32                                   
REMARK 500  8 PRO A  22       95.53    -69.69                                   
REMARK 500  8 LEU A  35      171.05    -55.25                                   
REMARK 500  8 ILE A  36      179.13    -56.07                                   
REMARK 500  8 ASN A  37       43.19    -86.33                                   
REMARK 500  8 PRO A  49        8.70    -69.70                                   
REMARK 500  8 ALA A  71      -75.19    -42.99                                   
REMARK 500  8 ASP A  72      -74.97    -47.91                                   
REMARK 500  8 VAL A  77       75.94   -105.01                                   
REMARK 500  8 THR A 102      149.57   -173.27                                   
REMARK 500  8 HIS A 105      -62.24   -130.36                                   
REMARK 500  8 PRO A 107     -178.38    -69.74                                   
REMARK 500  8 CYS A 111       45.21    -79.75                                   
REMARK 500  9 LEU A  35      -75.43    -59.95                                   
REMARK 500  9 GLU A  46      -75.39    -89.65                                   
REMARK 500  9 PRO A  49     -162.41    -69.75                                   
REMARK 500  9 TYR A  65      110.16   -160.78                                   
REMARK 500  9 TYR A  76      119.81   -168.68                                   
REMARK 500  9 GLU A  80      -34.12   -131.12                                   
REMARK 500  9 THR A 102      142.01   -173.99                                   
REMARK 500  9 HIS A 105      -73.73    -75.25                                   
REMARK 500  9 ALA A 108      137.61   -175.17                                   
REMARK 500  9 LYS A 110       48.48    -94.30                                   
REMARK 500  9 PRO A 116        0.31    -69.64                                   
REMARK 500  9 SER A 117       54.95    -95.07                                   
REMARK 500 10 HIS A  16      159.11    -47.92                                   
REMARK 500 10 LEU A  35      170.72    -52.81                                   
REMARK 500 10 TYR A  58      119.16   -170.19                                   
REMARK 500 10 VAL A  77       74.21   -107.17                                   
REMARK 500 10 THR A  78      133.20   -177.53                                   
REMARK 500 10 ASP A  98       29.42     46.25                                   
REMARK 500 10 LEU A 100      151.91    -41.63                                   
REMARK 500 10 THR A 102      135.61   -174.48                                   
REMARK 500 10 THR A 103      110.40    -38.85                                   
REMARK 500 10 LEU A 104      106.69    -41.00                                   
REMARK 500 10 HIS A 105      -73.31    -79.42                                   
REMARK 500 11 SER A   5      170.33    -54.22                                   
REMARK 500 11 SER A   6      158.52    -38.79                                   
REMARK 500 11 LYS A  15      -37.49    -34.23                                   
REMARK 500 11 HIS A  16      123.25    -34.60                                   
REMARK 500 11 TYR A  19       74.15    -67.62                                   
REMARK 500 11 HIS A  20       41.26    -82.07                                   
REMARK 500 11 LEU A  31      -29.21    -39.81                                   
REMARK 500 11 SER A  33       37.77     38.05                                   
REMARK 500 11 ASN A  37      -35.32    -34.28                                   
REMARK 500 11 SER A  47       37.19     34.13                                   
REMARK 500 11 PRO A  49     -162.98    -69.83                                   
REMARK 500 11 GLU A  59       93.50    -31.77                                   
REMARK 500 11 ASN A  68     -178.40    -60.86                                   
REMARK 500 11 ASP A  72       43.34    -80.80                                   
REMARK 500 11 TYR A  76      124.87   -173.99                                   
REMARK 500 11 VAL A  77       76.01   -104.27                                   
REMARK 500 11 THR A 102      140.72   -174.17                                   
REMARK 500 11 LEU A 104      109.14    -40.37                                   
REMARK 500 11 HIS A 105      -72.85    -79.11                                   
REMARK 500 11 PRO A 107     -178.21    -69.76                                   
REMARK 500 11 CYS A 111       52.17   -110.50                                   
REMARK 500 11 PRO A 116     -175.37    -69.69                                   
REMARK 500 12 ASN A  11       50.42     34.60                                   
REMARK 500 12 TYR A  19      104.95    -59.72                                   
REMARK 500 12 TYR A  76      123.48   -173.29                                   
REMARK 500 12 VAL A  77       75.93   -100.13                                   
REMARK 500 12 HIS A  93       31.44    -85.20                                   
REMARK 500 12 ASP A  98       82.12    -55.62                                   
REMARK 500 12 LEU A 104       85.40    -64.74                                   
REMARK 500 12 PRO A 107     -172.27    -69.80                                   
REMARK 500 12 PRO A 116       91.11    -69.77                                   
REMARK 500 13 PRO A   9     -168.26    -69.83                                   
REMARK 500 13 VAL A  10       38.26     30.64                                   
REMARK 500 13 PRO A  22       91.20    -69.78                                   
REMARK 500 13 ASN A  37       44.28    -80.46                                   
REMARK 500 13 TYR A  76      114.27   -169.71                                   
REMARK 500 13 GLU A  80      -43.98   -130.30                                   
REMARK 500 13 SER A  94      -34.19    -35.21                                   
REMARK 500 13 THR A 102      148.69   -173.59                                   
REMARK 500 13 LEU A 104       98.81    -62.12                                   
REMARK 500 13 PRO A 107     -170.74    -69.78                                   
REMARK 500 13 PRO A 109     -173.34    -69.91                                   
REMARK 500 13 LYS A 113      134.45    -34.28                                   
REMARK 500 13 SER A 117       42.27     34.31                                   
REMARK 500 14 LEU A  13      -61.13   -122.17                                   
REMARK 500 14 TYR A  19       97.43    -62.32                                   
REMARK 500 14 HIS A  20       45.53   -109.60                                   
REMARK 500 14 ILE A  36      172.48    -51.81                                   
REMARK 500 14 ASN A  37       34.10    -93.71                                   
REMARK 500 14 PRO A  49       84.49    -69.73                                   
REMARK 500 14 ASP A  72      -70.42    -52.97                                   
REMARK 500 14 TYR A  76      116.42   -173.56                                   
REMARK 500 14 GLU A  80      -39.43   -134.71                                   
REMARK 500 14 SER A  94      -19.96    -48.04                                   
REMARK 500 14 THR A  95      -73.49    -88.33                                   
REMARK 500 14 VAL A 101      -39.44    -33.60                                   
REMARK 500 14 THR A 103      151.54    -43.32                                   
REMARK 500 14 PRO A 107     -169.19    -69.69                                   
REMARK 500 14 SER A 117      112.88   -167.68                                   
REMARK 500 14 SER A 118      161.03    -40.40                                   
REMARK 500 15 VAL A  10      -38.80    -34.96                                   
REMARK 500 15 GLU A  14       45.49    -77.52                                   
REMARK 500 15 PRO A  22       90.52    -69.72                                   
REMARK 500 15 SER A  47      -70.53    -70.25                                   
REMARK 500 15 THR A  70      -59.28   -130.23                                   
REMARK 500 15 TYR A  76      118.19   -168.25                                   
REMARK 500 15 GLU A  80      -38.63   -135.03                                   
REMARK 500 15 SER A  84      -60.80    -94.39                                   
REMARK 500 15 ALA A  87      -38.09    -36.25                                   
REMARK 500 15 SER A  94      -28.98    -37.80                                   
REMARK 500 15 ASP A  98       88.78    -47.06                                   
REMARK 500 15 PRO A 107     -177.95    -69.82                                   
REMARK 500 15 PRO A 109     -179.34    -69.86                                   
REMARK 500 15 PRO A 116        2.00    -69.75                                   
REMARK 500 15 SER A 117       95.79    -34.86                                   
REMARK 500 16 SER A   2      113.92   -161.90                                   
REMARK 500 16 SER A   5      160.36    -41.51                                   
REMARK 500 16 VAL A  10       25.76     39.22                                   
REMARK 500 16 LYS A  15      -33.74    -34.44                                   
REMARK 500 16 HIS A  16      168.33    -47.22                                   
REMARK 500 16 ARG A  25      -38.21    -34.58                                   
REMARK 500 16 LEU A  35      -75.37    -58.72                                   
REMARK 500 16 ASN A  37       30.86    -84.90                                   
REMARK 500 16 TYR A  76      117.27   -167.27                                   
REMARK 500 16 THR A  78      146.41   -176.90                                   
REMARK 500 16 THR A 102      148.05   -171.49                                   
REMARK 500 16 PRO A 107     -179.09    -69.82                                   
REMARK 500 16 LYS A 113      -55.39   -127.01                                   
REMARK 500 16 SER A 118      126.68   -170.47                                   
REMARK 500 17 VAL A  10       46.34     32.61                                   
REMARK 500 17 TYR A  19      121.37    -38.74                                   
REMARK 500 17 PRO A  22       90.98    -69.81                                   
REMARK 500 17 SER A  34       32.43    -89.64                                   
REMARK 500 17 SER A  45      128.89    -36.55                                   
REMARK 500 17 GLU A  59       95.12    -30.76                                   
REMARK 500 17 ARG A  66       85.68    -66.15                                   
REMARK 500 17 ILE A  67      137.77    -37.44                                   
REMARK 500 17 TYR A  76      120.55   -172.14                                   
REMARK 500 17 VAL A  77       76.26   -101.18                                   
REMARK 500 17 GLU A  80      -38.80   -131.00                                   
REMARK 500 17 ASP A  98       92.82    -38.48                                   
REMARK 500 17 THR A 103      108.68    -37.86                                   
REMARK 500 17 HIS A 105      -68.74   -105.99                                   
REMARK 500 18 SER A   2       87.16    -69.59                                   
REMARK 500 18 PRO A   9     -168.67    -69.73                                   
REMARK 500 18 VAL A  10       43.09     29.69                                   
REMARK 500 18 LEU A  13      -73.49    -71.19                                   
REMARK 500 18 LEU A  35      155.16    -47.86                                   
REMARK 500 18 ILE A  36     -178.45    -61.44                                   
REMARK 500 18 ASN A  37       48.05    -86.87                                   
REMARK 500 18 PRO A  49       82.38    -69.85                                   
REMARK 500 18 GLU A  59       38.70     36.38                                   
REMARK 500 18 TYR A  76      118.54   -171.20                                   
REMARK 500 18 VAL A  77       75.98   -100.19                                   
REMARK 500 18 ASP A  98       87.76    -49.62                                   
REMARK 500 18 LEU A 104      109.13    -55.60                                   
REMARK 500 18 PRO A 107     -176.10    -69.71                                   
REMARK 500 18 LYS A 110      164.44    -46.81                                   
REMARK 500 18 ASN A 112       38.80     38.53                                   
REMARK 500 18 PRO A 116       93.90    -69.78                                   
REMARK 500 19 VAL A  10      163.74    -41.33                                   
REMARK 500 19 ASN A  11      152.91    -35.79                                   
REMARK 500 19 GLU A  14       48.17    -91.42                                   
REMARK 500 19 ASN A  37       47.46    -75.68                                   
REMARK 500 19 ARG A  66       86.20    -66.74                                   
REMARK 500 19 ILE A  67       99.53    -43.01                                   
REMARK 500 19 ASP A  72       47.71     73.56                                   
REMARK 500 19 TYR A  76      132.23   -175.10                                   
REMARK 500 19 VAL A  77       73.99   -103.76                                   
REMARK 500 19 SER A  94      -37.42    -33.31                                   
REMARK 500 19 VAL A 101      -34.36    -39.18                                   
REMARK 500 19 ALA A 108      134.45    -38.55                                   
REMARK 500 19 PRO A 109     -168.69    -69.78                                   
REMARK 500 19 CYS A 111      125.95    -34.55                                   
REMARK 500 20 PRO A  22       90.47    -69.74                                   
REMARK 500 20 ARG A  25      -35.43    -33.36                                   
REMARK 500 20 ALA A  28      -70.29    -50.00                                   
REMARK 500 20 LEU A  35      158.45    -45.10                                   
REMARK 500 20 ILE A  36      169.34    -45.50                                   
REMARK 500 20 ASN A  37       43.73    -82.21                                   
REMARK 500 20 GLU A  59       93.27    -34.47                                   
REMARK 500 20 THR A  70      -75.04   -118.15                                   
REMARK 500 20 ALA A  71      -74.54   -124.65                                   
REMARK 500 20 TYR A  76      113.94   -165.74                                   
REMARK 500 20 GLU A  80      -40.32   -133.78                                   
REMARK 500 20 SER A  94      -33.86    -36.34                                   
REMARK 500 20 ASP A  98       91.79    -40.87                                   
REMARK 500 20 THR A 102      138.64   -172.20                                   
REMARK 500 20 LEU A 104       96.74    -56.69                                   
REMARK 500 20 HIS A 105      -71.73    -65.56                                   
REMARK 500 20 PRO A 109     -173.17    -69.80                                   
REMARK 500 20 CYS A 111       47.83    -78.58                                   
REMARK 500 20 ASN A 112      -60.38   -102.05                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: HSS001001181.1   RELATED DB: TARGETDB                    
DBREF  2ECD A    8   113  UNP    P42684   ABL2_HUMAN     163    268             
SEQADV 2ECD GLY A    1  UNP  P42684              EXPRESSION TAG                 
SEQADV 2ECD SER A    2  UNP  P42684              EXPRESSION TAG                 
SEQADV 2ECD SER A    3  UNP  P42684              EXPRESSION TAG                 
SEQADV 2ECD GLY A    4  UNP  P42684              EXPRESSION TAG                 
SEQADV 2ECD SER A    5  UNP  P42684              EXPRESSION TAG                 
SEQADV 2ECD SER A    6  UNP  P42684              EXPRESSION TAG                 
SEQADV 2ECD GLY A    7  UNP  P42684              EXPRESSION TAG                 
SEQADV 2ECD SER A  114  UNP  P42684              EXPRESSION TAG                 
SEQADV 2ECD GLY A  115  UNP  P42684              EXPRESSION TAG                 
SEQADV 2ECD PRO A  116  UNP  P42684              EXPRESSION TAG                 
SEQADV 2ECD SER A  117  UNP  P42684              EXPRESSION TAG                 
SEQADV 2ECD SER A  118  UNP  P42684              EXPRESSION TAG                 
SEQADV 2ECD GLY A  119  UNP  P42684              EXPRESSION TAG                 
SEQRES   1 A  119  GLY SER SER GLY SER SER GLY THR PRO VAL ASN SER LEU          
SEQRES   2 A  119  GLU LYS HIS SER TRP TYR HIS GLY PRO VAL SER ARG SER          
SEQRES   3 A  119  ALA ALA GLU TYR LEU LEU SER SER LEU ILE ASN GLY SER          
SEQRES   4 A  119  PHE LEU VAL ARG GLU SER GLU SER SER PRO GLY GLN LEU          
SEQRES   5 A  119  SER ILE SER LEU ARG TYR GLU GLY ARG VAL TYR HIS TYR          
SEQRES   6 A  119  ARG ILE ASN THR THR ALA ASP GLY LYS VAL TYR VAL THR          
SEQRES   7 A  119  ALA GLU SER ARG PHE SER THR LEU ALA GLU LEU VAL HIS          
SEQRES   8 A  119  HIS HIS SER THR VAL ALA ASP GLY LEU VAL THR THR LEU          
SEQRES   9 A  119  HIS TYR PRO ALA PRO LYS CYS ASN LYS SER GLY PRO SER          
SEQRES  10 A  119  SER GLY                                                      
HELIX    1   1 SER A   24  SER A   34  1                                  11    
HELIX    2   2 THR A   85  VAL A   96  1                                  12    
SHEET    1   A 4 TYR A  19  PRO A  22  0                                        
SHEET    2   A 4 PHE A  40  SER A  45  1  O  VAL A  42   N  HIS A  20           
SHEET    3   A 4 GLN A  51  ARG A  57 -1  O  GLN A  51   N  SER A  45           
SHEET    4   A 4 VAL A  62  TYR A  65 -1  O  TYR A  63   N  LEU A  56           
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
MODEL        1                                                                  
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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