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Database: PDB
Entry: 2FIN
LinkDB: 2FIN
Original site: 2FIN 
HEADER    VIRUS/VIRAL PROTEIN/CYTOKINE            29-DEC-05   2FIN              
TITLE     SOLUTION STRUCTURE OF THE COMPLEX BETWEEN POXVIRUS-ENCODED            
TITLE    2 CC CHEMOKINE INHIBITOR VCCI AND HUMAN MIP-1BETA, ENSEMBLE            
TITLE    3 STRUCTURE                                                            
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: RABBITPOX ENCODED CC CHEMOKINE INHIBITOR;                  
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: VCCI, 35 KDA, P35;                                          
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: SMALL INDUCIBLE CYTOKINE A4;                               
COMPND   8 CHAIN: B;                                                            
COMPND   9 SYNONYM: MACROPHAGE INFLAMMATORY PROTEIN 1-BETA, MIP-1-              
COMPND  10 BETA;                                                                
COMPND  11 ENGINEERED: YES;                                                     
COMPND  12 MUTATION: YES                                                        
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: RABBITPOX VIRUS;                                
SOURCE   3 ORGANISM_TAXID: 32606;                                               
SOURCE   4 EXPRESSION_SYSTEM: PICHIA PASTORIS;                                  
SOURCE   5 EXPRESSION_SYSTEM_TAXID: 4922;                                       
SOURCE   6 EXPRESSION_SYSTEM_STRAIN: SMD1168;                                   
SOURCE   7 EXPRESSION_SYSTEM_VECTOR_TYPE: PPIC9K;                               
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: CCL4, LAG1, MIP1B, SCYA4;                                      
SOURCE  13 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);                       
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE  15 EXPRESSION_SYSTEM_STRAIN: BL21-DE3;                                  
SOURCE  16 EXPRESSION_SYSTEM_VECTOR_TYPE: PET-32 XA/LIC                         
KEYWDS    PROTEIN-PROTEIN COMPLEX, CHEMOKINE, POX VIRUS, VIRAL CC               
KEYWDS   2 CHEMOKINE INHIBITOR, VIRUS/VIRAL PROTEIN/CYTOKINE COMPLEX            
EXPDTA    SOLUTION NMR                                                          
NUMMDL    15                                                                    
AUTHOR    L.ZHANG                                                               
REVDAT   3   24-FEB-09 2FIN    1       VERSN                                    
REVDAT   2   03-OCT-06 2FIN    1       JRNL                                     
REVDAT   1   22-AUG-06 2FIN    0                                                
JRNL        AUTH   L.ZHANG,M.DERIDER,M.A.MCCORNACK,S.C.JAO,N.ISERN,             
JRNL        AUTH 2 T.NESS,R.MOYER,P.J.LIWANG                                    
JRNL        TITL   SOLUTION STRUCTURE OF THE COMPLEX BETWEEN                    
JRNL        TITL 2 POXVIRUS-ENCODED CC CHEMOKINE INHIBITOR VCCI AND             
JRNL        TITL 3 HUMAN MIP-1BETA.                                             
JRNL        REF    PROC.NATL.ACAD.SCI.USA        V. 103 13985 2006              
JRNL        REFN                   ISSN 0027-8424                               
JRNL        PMID   16963564                                                     
JRNL        DOI    10.1073/PNAS.0602142103                                      
REMARK   1                                                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION. NOT APPLICABLE.                                          
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : DYNAMO 3.1                                           
REMARK   3   AUTHORS     : FRANK DELAGLIO                                       
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 2FIN COMPLIES WITH FORMAT V. 3.15, 01-DEC-08                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 20-JAN-06.                  
REMARK 100 THE RCSB ID CODE IS RCSB035922.                                      
REMARK 210                                                                      
REMARK 210 EXPERIMENTAL DETAILS                                                 
REMARK 210  EXPERIMENT TYPE                : NMR                                
REMARK 210  TEMPERATURE           (KELVIN) : 310                                
REMARK 210  PH                             : 7.0                                
REMARK 210  IONIC STRENGTH                 : 100MM                              
REMARK 210  PRESSURE                       : 1 ATM                              
REMARK 210  SAMPLE CONTENTS                : 0.5-2.0 MM                         
REMARK 210                                                                      
REMARK 210  NMR EXPERIMENTS CONDUCTED      : 3D_13C-SEPARATED_NOESY, 3D_        
REMARK 210                                   15N-SEPARATED_NOESY, 4D_13C/       
REMARK 210                                   15N-SEPARATED_NOESY                
REMARK 210  SPECTROMETER FIELD STRENGTH    : 600 MHZ, 750 MHZ, 800 MHZ          
REMARK 210  SPECTROMETER MODEL             : INOVA                              
REMARK 210  SPECTROMETER MANUFACTURER      : VARIAN                             
REMARK 210                                                                      
REMARK 210  STRUCTURE DETERMINATION.                                            
REMARK 210   SOFTWARE USED                 : NMRPIPE LINUX9, DYNAMO 3.1         
REMARK 210   METHOD USED                   : NULL                               
REMARK 210                                                                      
REMARK 210 CONFORMERS, NUMBER CALCULATED   : 100                                
REMARK 210 CONFORMERS, NUMBER SUBMITTED    : 15                                 
REMARK 210 CONFORMERS, SELECTION CRITERIA  : STRUCTURES WITH THE LEAST          
REMARK 210                                   RESTRAINT VIOLATIONS,              
REMARK 210                                   STRUCTURES WITH THE LOWEST         
REMARK 210                                   ENERGY                             
REMARK 210                                                                      
REMARK 210 BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE : NULL                
REMARK 210                                                                      
REMARK 210 REMARK: NULL                                                         
REMARK 215                                                                      
REMARK 215 NMR STUDY                                                            
REMARK 215 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM SOLUTION           
REMARK 215 NMR DATA.  PROTEIN DATA BANK CONVENTIONS REQUIRE THAT                
REMARK 215 CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES ON              
REMARK 215 THESE RECORDS ARE MEANINGLESS.                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500  1 PRO A   2     -171.88    -51.77                                   
REMARK 500  1 ALA A   3      175.18     53.49                                   
REMARK 500  1 SER A   4       -8.87   -165.61                                   
REMARK 500  1 GLN A   7     -143.11    -60.95                                   
REMARK 500  1 SER A   8      -14.70   -158.11                                   
REMARK 500  1 GLU A  19      -63.11    -27.60                                   
REMARK 500  1 GLN A  37      -23.44   -172.09                                   
REMARK 500  1 PRO A  39      159.17    -39.62                                   
REMARK 500  1 ASN A  41      101.15   -174.08                                   
REMARK 500  1 ILE A  44      176.09    -57.83                                   
REMARK 500  1 SER A  47      165.52    178.71                                   
REMARK 500  1 SER A  54      -46.09     74.15                                   
REMARK 500  1 SER A  56     -105.76     39.71                                   
REMARK 500  1 ASP A  57      -37.82   -160.31                                   
REMARK 500  1 PRO A  58      -94.95    -80.92                                   
REMARK 500  1 ASP A  59       51.67   -176.13                                   
REMARK 500  1 GLU A  61       61.64     62.72                                   
REMARK 500  1 VAL A  62      -25.42     72.54                                   
REMARK 500  1 GLU A  63       63.04     63.35                                   
REMARK 500  1 ASP A  66       90.89   -167.81                                   
REMARK 500  1 SER A  68      -47.33   -173.56                                   
REMARK 500  1 THR A  69      -39.96   -172.75                                   
REMARK 500  1 VAL A  71       33.93   -158.28                                   
REMARK 500  1 ASP A  73      -98.60    -34.35                                   
REMARK 500  1 VAL A  74      -80.22     57.33                                   
REMARK 500  1 PRO A  77     -147.51    -55.84                                   
REMARK 500  1 SER A  82       66.18   -105.03                                   
REMARK 500  1 PRO A  98      148.03    -39.10                                   
REMARK 500  1 PRO A 121      162.25    -40.32                                   
REMARK 500  1 GLN A 123      -46.13   -140.11                                   
REMARK 500  1 SER A 127       61.89   -163.21                                   
REMARK 500  1 ASP A 147       77.07   -158.29                                   
REMARK 500  1 ARG A 149     -149.11   -134.70                                   
REMARK 500  1 GLU A 152       10.79   -147.50                                   
REMARK 500  1 THR A 161       -2.33    -57.95                                   
REMARK 500  1 PRO A 163      160.46    -40.49                                   
REMARK 500  1 ASN A 168       -0.65     58.75                                   
REMARK 500  1 LYS A 172     -166.90    -58.26                                   
REMARK 500  1 LYS A 188      -16.98    -44.93                                   
REMARK 500  1 CYS A 189       24.55   -143.71                                   
REMARK 500  1 VAL A 190      104.27   -163.98                                   
REMARK 500  1 ARG A 198      113.87   -171.79                                   
REMARK 500  1 LYS A 204      117.56   -161.69                                   
REMARK 500  1 GLU A 205      156.40    -43.98                                   
REMARK 500  1 SER A 206       17.80   -141.11                                   
REMARK 500  1 SER A 207      -74.22     56.28                                   
REMARK 500  1 ASP A 228       95.52    -67.09                                   
REMARK 500  1 SER B   5      -91.81    -54.75                                   
REMARK 500  1 PRO B   8      -99.34    -34.33                                   
REMARK 500  1 THR B   9      165.20    163.50                                   
REMARK 500  1 ALA B  10       57.93   -142.92                                   
REMARK 500  1 PRO B  21      153.44    -42.67                                   
REMARK 500  1 ASN B  23      -34.69    -38.89                                   
REMARK 500  1 THR B  31     -110.38    -53.11                                   
REMARK 500  1 SER B  32     -145.72   -150.81                                   
REMARK 500  1 SER B  33      -22.90   -141.38                                   
REMARK 500  1 LEU B  34       -5.33    -59.23                                   
REMARK 500  1 SER B  36       36.94    -72.66                                   
REMARK 500  1 GLN B  37       60.86   -167.51                                   
REMARK 500  1 PRO B  38     -161.02    -70.16                                   
REMARK 500  1 ALA B  39      176.92    173.48                                   
REMARK 500  1 THR B  44     -142.92   -136.12                                   
REMARK 500  1 SER B  47      -79.61   -151.48                                   
REMARK 500  1 ALA B  48      -90.22    155.58                                   
REMARK 500  1 LEU B  68      -77.49    -76.40                                   
REMARK 500  2 PRO A   2      163.55    -43.04                                   
REMARK 500  2 ALA A   3     -174.76    -58.43                                   
REMARK 500  2 SER A   4     -165.30   -165.88                                   
REMARK 500  2 LEU A   5       98.07     53.86                                   
REMARK 500  2 GLN A   7     -143.50    -69.17                                   
REMARK 500  2 SER A   8      -18.73   -168.31                                   
REMARK 500  2 GLU A  18     -164.42    -61.98                                   
REMARK 500  2 GLU A  19      -62.85   -127.01                                   
REMARK 500  2 ASN A  20       34.74    -82.15                                   
REMARK 500  2 PRO A  39      159.48    -43.03                                   
REMARK 500  2 LYS A  43       81.47    -58.40                                   
REMARK 500  2 GLU A  53      169.39    -45.26                                   
REMARK 500  2 GLU A  55       88.76    -30.85                                   
REMARK 500  2 PRO A  58      107.24    -34.88                                   
REMARK 500  2 GLU A  63     -155.16    -83.40                                   
REMARK 500  2 GLU A  65      -89.78    -41.08                                   
REMARK 500  2 SER A  68       44.39     80.54                                   
REMARK 500  2 THR A  69      -14.10   -149.79                                   
REMARK 500  2 SER A  70      -53.75   -168.89                                   
REMARK 500  2 VAL A  71       72.72     51.93                                   
REMARK 500  2 GLU A  72      -49.92   -154.85                                   
REMARK 500  2 VAL A  74     -154.04    -69.10                                   
REMARK 500  2 PRO A  76       95.57    -33.24                                   
REMARK 500  2 PHE A  92     -169.93   -102.75                                   
REMARK 500  2 PRO A  98      152.42    -38.70                                   
REMARK 500  2 SER A 127       62.66   -155.43                                   
REMARK 500  2 ASP A 147       86.89   -160.77                                   
REMARK 500  2 GLU A 153      101.57    -51.34                                   
REMARK 500  2 PRO A 163      157.01    -39.18                                   
REMARK 500  2 ASN A 168       -3.37     59.24                                   
REMARK 500  2 HIS A 171       39.42    -73.55                                   
REMARK 500  2 CYS A 189       40.29   -143.09                                   
REMARK 500  2 ARG A 198      111.27   -169.35                                   
REMARK 500  2 GLU A 205      158.30    -42.72                                   
REMARK 500  2 SER A 207      -75.87     58.44                                   
REMARK 500  2 ASP A 228       95.74    -63.32                                   
REMARK 500  2 ASP A 229       35.92    -89.95                                   
REMARK 500  2 ASP B   6       74.73     48.37                                   
REMARK 500  2 PRO B   8     -122.23    -38.18                                   
REMARK 500  2 THR B   9       68.83    157.23                                   
REMARK 500  2 ALA B  10       82.47    -66.45                                   
REMARK 500  2 ASN B  23      -34.61    -37.72                                   
REMARK 500  2 PHE B  24       42.40   -107.54                                   
REMARK 500  2 THR B  31     -116.10    -55.69                                   
REMARK 500  2 SER B  32     -156.07   -149.43                                   
REMARK 500  2 LEU B  34       -9.84    -53.09                                   
REMARK 500  2 SER B  36       42.47    -74.57                                   
REMARK 500  2 GLN B  37       56.86   -166.31                                   
REMARK 500  2 PRO B  38     -161.58    -67.97                                   
REMARK 500  2 ALA B  39      177.39    167.83                                   
REMARK 500  2 THR B  44     -138.21    -75.62                                   
REMARK 500  2 ALA B  45      -32.22   -131.02                                   
REMARK 500  2 SER B  47      -83.35   -142.94                                   
REMARK 500  2 ALA B  48      -90.73    154.58                                   
REMARK 500  2 LEU B  68      -79.51    -83.66                                   
REMARK 500  3 PRO A   2     -173.34    -51.76                                   
REMARK 500  3 THR A  38      104.96    -40.98                                   
REMARK 500  3 PRO A  39      164.50    -44.50                                   
REMARK 500  3 ASN A  41       97.01   -171.64                                   
REMARK 500  3 LYS A  43       87.93    -65.10                                   
REMARK 500  3 SER A  47      164.63    174.29                                   
REMARK 500  3 GLU A  53     -176.16    -52.95                                   
REMARK 500  3 GLU A  55      178.23     50.38                                   
REMARK 500  3 SER A  56       59.08    -91.66                                   
REMARK 500  3 PRO A  58       89.32    -42.49                                   
REMARK 500  3 ASP A  59       59.60   -179.57                                   
REMARK 500  3 GLU A  63      168.18     88.05                                   
REMARK 500  3 SER A  64      -17.18    165.02                                   
REMARK 500  3 ASP A  66      -70.09    -58.58                                   
REMARK 500  3 THR A  69      -45.22   -140.83                                   
REMARK 500  3 SER A  70     -161.93     50.89                                   
REMARK 500  3 VAL A  71       29.53    -75.21                                   
REMARK 500  3 GLU A  72       76.31     55.13                                   
REMARK 500  3 ASP A  73       21.66   -164.28                                   
REMARK 500  3 PRO A  77     -143.47    -79.89                                   
REMARK 500  3 PHE A  92     -167.09   -102.17                                   
REMARK 500  3 PRO A  98      147.55    -37.79                                   
REMARK 500  3 SER A 127       63.20   -154.38                                   
REMARK 500  3 PRO A 128      151.61    -40.54                                   
REMARK 500  3 ASP A 147       88.83   -152.32                                   
REMARK 500  3 LYS A 155      173.98    -52.81                                   
REMARK 500  3 THR A 161        6.99    -65.09                                   
REMARK 500  3 PRO A 163      158.13    -40.87                                   
REMARK 500  3 ASN A 168       -5.87     60.48                                   
REMARK 500  3 HIS A 171       37.86    -72.45                                   
REMARK 500  3 LYS A 172     -173.40    -66.64                                   
REMARK 500  3 ASP A 178       99.00    -61.77                                   
REMARK 500  3 LYS A 188      -38.37    -34.58                                   
REMARK 500  3 CYS A 189       31.32   -142.15                                   
REMARK 500  3 LEU A 193      105.95    179.45                                   
REMARK 500  3 ARG A 198      106.60   -166.30                                   
REMARK 500  3 SER A 207      -76.63     58.31                                   
REMARK 500  3 PHE A 215     -168.94   -119.69                                   
REMARK 500  3 SER A 223      110.43   -168.13                                   
REMARK 500  3 ASP A 228       95.93    -51.16                                   
REMARK 500  3 SER A 235        1.51    -62.22                                   
REMARK 500  3 ASP B   6       84.70    -21.00                                   
REMARK 500  3 PRO B   7     -173.60    -65.85                                   
REMARK 500  3 PRO B   8     -132.73    -54.34                                   
REMARK 500  3 THR B   9       45.06    177.73                                   
REMARK 500  3 ALA B  10       93.84    -48.32                                   
REMARK 500  3 CYS B  12      135.82    -39.71                                   
REMARK 500  3 ASN B  23      -34.73    -37.36                                   
REMARK 500  3 PHE B  24       44.32   -106.78                                   
REMARK 500  3 THR B  31     -112.39    -55.03                                   
REMARK 500  3 SER B  32     -141.34   -150.28                                   
REMARK 500  3 SER B  33      -24.42   -143.04                                   
REMARK 500  3 LEU B  34       -6.71    -58.12                                   
REMARK 500  3 SER B  36       38.17    -73.12                                   
REMARK 500  3 GLN B  37       58.99   -165.74                                   
REMARK 500  3 PRO B  38     -170.48    -67.81                                   
REMARK 500  3 THR B  44     -143.22   -140.10                                   
REMARK 500  3 SER B  47      -82.24   -153.54                                   
REMARK 500  3 ALA B  48      -90.10    156.05                                   
REMARK 500  3 LEU B  68      -70.25    -75.01                                   
REMARK 500  4 PRO A   2     -172.34    -49.88                                   
REMARK 500  4 ALA A   3     -151.91   -167.50                                   
REMARK 500  4 SER A   4      -50.92   -170.03                                   
REMARK 500  4 GLN A   6       83.17   -164.95                                   
REMARK 500  4 SER A   8      -11.94   -167.39                                   
REMARK 500  4 GLU A  19      -31.05    -32.42                                   
REMARK 500  4 ASN A  20       38.65    -95.49                                   
REMARK 500  4 THR A  38      106.90    -44.14                                   
REMARK 500  4 PRO A  39      161.74    -43.79                                   
REMARK 500  4 ASN A  41      102.68   -173.49                                   
REMARK 500  4 LYS A  43       89.39    -64.93                                   
REMARK 500  4 GLU A  53      179.64    -52.15                                   
REMARK 500  4 GLU A  55       90.61    -65.24                                   
REMARK 500  4 SER A  56      -96.17    175.14                                   
REMARK 500  4 ASP A  57       -4.65   -169.48                                   
REMARK 500  4 PRO A  58      -98.74    -79.40                                   
REMARK 500  4 ASP A  59      -59.14   -155.13                                   
REMARK 500  4 PRO A  60      112.31    -19.86                                   
REMARK 500  4 GLU A  61     -145.03   -100.14                                   
REMARK 500  4 VAL A  62      -98.32   -165.55                                   
REMARK 500  4 SER A  64     -172.04     60.01                                   
REMARK 500  4 ASP A  66       46.42   -156.30                                   
REMARK 500  4 SER A  68     -149.80     62.87                                   
REMARK 500  4 THR A  69       65.87     33.63                                   
REMARK 500  4 VAL A  71      -46.20   -157.21                                   
REMARK 500  4 GLU A  72      -95.37    -46.59                                   
REMARK 500  4 ASP A  73       84.25    165.24                                   
REMARK 500  4 ASP A  75       67.24   -166.14                                   
REMARK 500  4 PHE A  92     -169.15   -100.11                                   
REMARK 500  4 LYS A  96       45.31     70.85                                   
REMARK 500  4 PRO A  98      142.72    -38.53                                   
REMARK 500  4 LYS A 101       -7.66   -145.50                                   
REMARK 500  4 ASN A 110       21.33   -142.86                                   
REMARK 500  4 GLN A 123      -51.82   -126.40                                   
REMARK 500  4 ASP A 126     -179.45    -63.96                                   
REMARK 500  4 SER A 127       59.76   -171.29                                   
REMARK 500  4 GLU A 152       14.18   -147.51                                   
REMARK 500  4 LYS A 155      158.49    -46.29                                   
REMARK 500  4 LYS A 160     -159.42   -109.85                                   
REMARK 500  4 PRO A 163      155.14    -39.36                                   
REMARK 500  4 ASN A 168      -11.53     62.73                                   
REMARK 500  4 HIS A 171       47.24    -79.05                                   
REMARK 500  4 SER A 175      132.71    -14.73                                   
REMARK 500  4 LYS A 188      -37.66    -39.40                                   
REMARK 500  4 ARG A 198      111.22   -164.96                                   
REMARK 500  4 CYS A 203      -61.32    -97.74                                   
REMARK 500  4 SER A 207      -76.12     58.81                                   
REMARK 500  4 ASP A 228       95.15    -61.36                                   
REMARK 500  4 ASP A 229       34.02    -86.84                                   
REMARK 500  4 SER B   5      -84.55    -76.54                                   
REMARK 500  4 PRO B   7     -168.83    -53.02                                   
REMARK 500  4 PRO B   8     -111.48    -88.17                                   
REMARK 500  4 THR B   9       72.60    158.01                                   
REMARK 500  4 ASN B  23       24.82    -68.09                                   
REMARK 500  4 PHE B  24       32.60   -150.88                                   
REMARK 500  4 THR B  31     -107.44    -52.35                                   
REMARK 500  4 SER B  32     -128.95   -146.93                                   
REMARK 500  4 SER B  33      -40.84   -158.95                                   
REMARK 500  4 LEU B  34       -2.11    -59.08                                   
REMARK 500  4 GLN B  37       49.61   -173.56                                   
REMARK 500  4 PRO B  38     -158.56    -58.63                                   
REMARK 500  4 ALA B  39      176.95    168.36                                   
REMARK 500  4 THR B  44     -142.73   -138.84                                   
REMARK 500  4 SER B  47      -80.33   -153.72                                   
REMARK 500  4 ALA B  48      -82.20    155.54                                   
REMARK 500  4 LEU B  68      -84.50    -79.11                                   
REMARK 500  5 PRO A   2     -157.45    -54.40                                   
REMARK 500  5 ALA A   3      -42.10   -169.76                                   
REMARK 500  5 SER A   4     -157.95     56.94                                   
REMARK 500  5 LEU A   5      108.06     58.44                                   
REMARK 500  5 GLN A   6       51.91   -150.06                                   
REMARK 500  5 GLN A   7     -166.26    -61.39                                   
REMARK 500  5 SER A   8      -58.10   -164.62                                   
REMARK 500  5 GLU A  18     -152.63    -62.52                                   
REMARK 500  5 GLU A  19      -72.15   -121.16                                   
REMARK 500  5 MET A  24      170.79    -46.54                                   
REMARK 500  5 GLN A  35     -170.55    -68.85                                   
REMARK 500  5 THR A  38      106.48    -40.70                                   
REMARK 500  5 PRO A  39      170.68    -43.68                                   
REMARK 500  5 LYS A  43       92.46    -63.74                                   
REMARK 500  5 SER A  47      164.82    178.09                                   
REMARK 500  5 GLU A  53      175.02    -52.71                                   
REMARK 500  5 GLU A  55      164.15    -44.95                                   
REMARK 500  5 SER A  56      -23.36    159.76                                   
REMARK 500  5 PRO A  58      -27.73    -35.49                                   
REMARK 500  5 PRO A  60     -164.30    -50.27                                   
REMARK 500  5 GLU A  61     -115.96   -119.93                                   
REMARK 500  5 VAL A  62       91.78     41.19                                   
REMARK 500  5 SER A  64     -120.71     55.95                                   
REMARK 500  5 GLU A  65     -137.40   -161.14                                   
REMARK 500  5 ASP A  66       -3.93     67.34                                   
REMARK 500  5 SER A  68      -14.86     73.18                                   
REMARK 500  5 VAL A  74     -130.47    -85.20                                   
REMARK 500  5 ASP A  75       71.87   -158.59                                   
REMARK 500  5 PHE A  92     -169.99   -116.81                                   
REMARK 500  5 PRO A  98      160.57    -38.64                                   
REMARK 500  5 LYS A 101      -21.92   -147.14                                   
REMARK 500  5 GLN A 123      -53.96   -133.71                                   
REMARK 500  5 PRO A 128      129.63    -37.17                                   
REMARK 500  5 ASP A 147       88.88   -163.58                                   
REMARK 500  5 GLU A 153       99.03    -55.37                                   
REMARK 500  5 LYS A 155      156.78    -45.43                                   
REMARK 500  5 ASN A 168       -3.45     60.97                                   
REMARK 500  5 HIS A 171       40.88    -75.59                                   
REMARK 500  5 SER A 175      141.14    -27.54                                   
REMARK 500  5 LYS A 188      -34.59    -34.97                                   
REMARK 500  5 CYS A 189       56.93   -152.10                                   
REMARK 500  5 VAL A 190       91.99   -173.77                                   
REMARK 500  5 ARG A 198      116.59   -174.19                                   
REMARK 500  5 SER A 207      -41.81    -23.45                                   
REMARK 500  5 GLU A 208      -73.43    -58.65                                   
REMARK 500  5 ASP A 219       -8.87     59.39                                   
REMARK 500  5 ASP A 228       95.94    -60.04                                   
REMARK 500  5 ASP A 229       30.66    -90.61                                   
REMARK 500  5 SER A 235       -4.14    -59.29                                   
REMARK 500  5 LYS A 237       13.62    -67.90                                   
REMARK 500  5 SER B   5      -88.89    -70.88                                   
REMARK 500  5 ASP B   6       66.64   -152.26                                   
REMARK 500  5 PRO B   8      176.37    -46.02                                   
REMARK 500  5 CYS B  12      129.17    -38.37                                   
REMARK 500  5 PRO B  21      152.76    -41.34                                   
REMARK 500  5 ASN B  23      -33.59    -37.57                                   
REMARK 500  5 PHE B  24       43.19   -109.50                                   
REMARK 500  5 THR B  31     -109.04    -54.31                                   
REMARK 500  5 SER B  32     -141.57   -152.58                                   
REMARK 500  5 SER B  33      -23.29   -146.53                                   
REMARK 500  5 SER B  36       37.86    -72.75                                   
REMARK 500  5 GLN B  37       60.17   -168.51                                   
REMARK 500  5 PRO B  38     -164.75    -68.60                                   
REMARK 500  5 ALA B  39      176.64    178.90                                   
REMARK 500  5 THR B  44     -145.09   -137.11                                   
REMARK 500  5 SER B  47      -83.00   -155.33                                   
REMARK 500  5 ALA B  48      -90.38    155.35                                   
REMARK 500  5 LEU B  68      -77.27    -78.56                                   
REMARK 500  6 ALA A   3      101.41     52.08                                   
REMARK 500  6 GLN A   7      -97.70    -84.41                                   
REMARK 500  6 SER A   8      -12.23   -154.28                                   
REMARK 500  6 ASN A  41       90.68   -167.02                                   
REMARK 500  6 LYS A  43       83.91    -61.05                                   
REMARK 500  6 GLU A  53     -176.53    -54.63                                   
REMARK 500  6 SER A  54       -2.97    102.22                                   
REMARK 500  6 GLU A  55      167.98     65.06                                   
REMARK 500  6 ASP A  59      106.99     59.88                                   
REMARK 500  6 PRO A  60       97.59    -43.68                                   
REMARK 500  6 GLU A  61       29.51     33.24                                   
REMARK 500  6 VAL A  62      -78.42    -76.40                                   
REMARK 500  6 SER A  64      163.90    -41.08                                   
REMARK 500  6 ASP A  66      100.17     51.99                                   
REMARK 500  6 SER A  68      -59.48   -145.28                                   
REMARK 500  6 VAL A  71      -76.20    -73.13                                   
REMARK 500  6 GLU A  72       28.65   -172.14                                   
REMARK 500  6 ASP A  73     -169.67   -110.07                                   
REMARK 500  6 VAL A  74       73.82     37.42                                   
REMARK 500  6 ASP A  75      150.48    -48.28                                   
REMARK 500  6 PRO A  76      156.95    -35.72                                   
REMARK 500  6 PHE A  92     -169.70   -100.90                                   
REMARK 500  6 PRO A  98      145.55    -38.61                                   
REMARK 500  6 LYS A 101       -9.56   -143.04                                   
REMARK 500  6 PRO A 121      155.62    -34.81                                   
REMARK 500  6 GLN A 123      -40.67   -154.75                                   
REMARK 500  6 SER A 127       66.18   -155.70                                   
REMARK 500  6 CYS A 142      120.42    -39.31                                   
REMARK 500  6 ASP A 147       88.67   -154.38                                   
REMARK 500  6 PRO A 163      161.11    -39.89                                   
REMARK 500  6 ASN A 168        0.70     58.76                                   
REMARK 500  6 HIS A 171       43.12    -75.79                                   
REMARK 500  6 LYS A 172     -174.52    -66.56                                   
REMARK 500  6 LYS A 188      -16.23    -43.49                                   
REMARK 500  6 CYS A 189       12.59   -148.43                                   
REMARK 500  6 ARG A 198      115.94   -171.70                                   
REMARK 500  6 SER A 207      -76.59     58.29                                   
REMARK 500  6 SER A 223      117.69   -168.28                                   
REMARK 500  6 ASP A 228       95.39    -57.68                                   
REMARK 500  6 LEU A 232      -33.14    -39.20                                   
REMARK 500  6 SER B   5      -76.49    -78.32                                   
REMARK 500  6 PRO B   7     -174.29    -61.36                                   
REMARK 500  6 PRO B   8     -138.85    -58.03                                   
REMARK 500  6 THR B   9       31.07   -178.53                                   
REMARK 500  6 ALA B  10       91.36    -41.36                                   
REMARK 500  6 PHE B  24       41.67   -108.53                                   
REMARK 500  6 THR B  31     -113.06    -57.20                                   
REMARK 500  6 SER B  32     -142.56   -151.66                                   
REMARK 500  6 SER B  33      -16.78   -143.32                                   
REMARK 500  6 SER B  36       44.14    -74.49                                   
REMARK 500  6 GLN B  37       57.85   -173.31                                   
REMARK 500  6 PRO B  38     -162.51    -72.61                                   
REMARK 500  6 ALA B  39      176.96    174.62                                   
REMARK 500  6 THR B  44     -145.39   -137.95                                   
REMARK 500  6 SER B  47      -83.79   -154.05                                   
REMARK 500  6 ALA B  48      -87.80    159.21                                   
REMARK 500  6 LEU B  68      -81.78    -82.26                                   
REMARK 500  7 GLN A   7     -139.19    -61.56                                   
REMARK 500  7 SER A   8      -44.11   -158.26                                   
REMARK 500  7 GLU A  19      -61.06    -17.71                                   
REMARK 500  7 HIS A  23       78.73    -67.79                                   
REMARK 500  7 ASP A  36       36.51    -74.12                                   
REMARK 500  7 GLN A  37      -46.98   -136.56                                   
REMARK 500  7 LYS A  43       87.38    -51.43                                   
REMARK 500  7 SER A  54      -48.17     69.87                                   
REMARK 500  7 GLU A  55      -85.55    -48.55                                   
REMARK 500  7 SER A  56      -91.17     51.90                                   
REMARK 500  7 ASP A  57      -61.95   -163.89                                   
REMARK 500  7 PRO A  58      -93.90    -55.58                                   
REMARK 500  7 PRO A  60      152.90    -36.33                                   
REMARK 500  7 GLU A  61       56.86   -168.46                                   
REMARK 500  7 VAL A  62     -106.52   -136.48                                   
REMARK 500  7 SER A  64      179.92    -50.99                                   
REMARK 500  7 GLU A  65       98.49     38.79                                   
REMARK 500  7 ASP A  66      -22.01   -175.83                                   
REMARK 500  7 ASP A  67     -127.00    -81.30                                   
REMARK 500  7 SER A  68     -104.77   -169.09                                   
REMARK 500  7 GLU A  72       80.34     43.94                                   
REMARK 500  7 ASP A  75       50.45   -173.06                                   
REMARK 500  7 PRO A  76      106.99    -55.95                                   
REMARK 500  7 PRO A  77     -159.88    -55.67                                   
REMARK 500  7 PRO A  98      135.58    -32.71                                   
REMARK 500  7 ALA A 114      119.55   -165.72                                   
REMARK 500  7 GLN A 123      -33.65   -143.67                                   
REMARK 500  7 PRO A 163      162.36    -39.06                                   
REMARK 500  7 ASN A 168      -10.18     67.07                                   
REMARK 500  7 HIS A 171       33.72    -77.22                                   
REMARK 500  7 CYS A 189       27.99   -142.49                                   
REMARK 500  7 VAL A 190       99.69   -165.18                                   
REMARK 500  7 ILE A 199      109.75   -160.96                                   
REMARK 500  7 ASP A 219      -12.68     64.58                                   
REMARK 500  7 SER A 223      120.74   -173.83                                   
REMARK 500  7 ASP A 228       95.65    -55.33                                   
REMARK 500  7 ASP A 229       36.18    -88.75                                   
REMARK 500  7 MET B   3      174.98    -48.24                                   
REMARK 500  7 SER B   5       25.94   -169.14                                   
REMARK 500  7 ASP B   6       50.24    161.38                                   
REMARK 500  7 PRO B   8     -123.80    -63.43                                   
REMARK 500  7 THR B   9       47.33    175.53                                   
REMARK 500  7 ALA B  10       95.35    -48.44                                   
REMARK 500  7 PRO B  21      152.24    -40.65                                   
REMARK 500  7 PHE B  24       46.05   -105.77                                   
REMARK 500  7 THR B  31     -115.35    -55.58                                   
REMARK 500  7 SER B  32     -156.15   -148.29                                   
REMARK 500  7 SER B  36       34.16    -73.54                                   
REMARK 500  7 GLN B  37       63.08   -168.67                                   
REMARK 500  7 PRO B  38     -161.41    -71.63                                   
REMARK 500  7 ALA B  39      176.94    173.35                                   
REMARK 500  7 THR B  44     -142.19   -143.84                                   
REMARK 500  7 SER B  47      -84.58   -147.42                                   
REMARK 500  7 ALA B  48      -84.68    154.01                                   
REMARK 500  7 LEU B  68      -75.04    -74.03                                   
REMARK 500  8 ALA A   3      -17.95   -164.72                                   
REMARK 500  8 LEU A   5       80.26     55.75                                   
REMARK 500  8 GLN A   7     -142.27     53.69                                   
REMARK 500  8 SER A   8      -13.20   -161.42                                   
REMARK 500  8 LYS A  43       85.78    -54.93                                   
REMARK 500  8 SER A  47     -172.15   -173.09                                   
REMARK 500  8 VAL A  48       91.26   -167.70                                   
REMARK 500  8 GLU A  53      160.42    -38.74                                   
REMARK 500  8 GLU A  55       39.00    -74.58                                   
REMARK 500  8 SER A  56      -91.77    -64.02                                   
REMARK 500  8 PRO A  58      -96.85    -85.82                                   
REMARK 500  8 GLU A  61       31.92   -175.72                                   
REMARK 500  8 GLU A  63      -55.52   -155.51                                   
REMARK 500  8 SER A  64     -103.22   -168.58                                   
REMARK 500  8 SER A  68       73.59   -164.21                                   
REMARK 500  8 SER A  70      105.59     61.98                                   
REMARK 500  8 VAL A  71      -34.04   -163.51                                   
REMARK 500  8 ASP A  73       81.75     49.23                                   
REMARK 500  8 ASP A  75       31.81   -175.60                                   
REMARK 500  8 SER A  82       67.00   -101.02                                   
REMARK 500  8 PHE A  92     -167.04   -112.05                                   
REMARK 500  8 LYS A  96       30.91     70.22                                   
REMARK 500  8 PRO A  98      148.04    -39.60                                   
REMARK 500  8 LYS A 101      -22.86   -156.80                                   
REMARK 500  8 ALA A 114      118.72   -164.41                                   
REMARK 500  8 PRO A 121      170.26    -40.08                                   
REMARK 500  8 GLN A 123     -115.55    -81.84                                   
REMARK 500  8 ASP A 147       94.95   -166.99                                   
REMARK 500  8 GLU A 152       -2.05   -155.49                                   
REMARK 500  8 ASP A 156      172.80    -55.74                                   
REMARK 500  8 PRO A 163      155.96    -40.35                                   
REMARK 500  8 ASN A 168       -8.36     64.15                                   
REMARK 500  8 HIS A 171       38.57    -74.19                                   
REMARK 500  8 LYS A 172     -170.79    -67.62                                   
REMARK 500  8 LYS A 188      -28.48    -36.40                                   
REMARK 500  8 CYS A 189       24.23   -149.34                                   
REMARK 500  8 LEU A 193      106.46   -169.22                                   
REMARK 500  8 ARG A 198      111.54   -170.67                                   
REMARK 500  8 SER A 207      -27.27    -37.11                                   
REMARK 500  8 ASP A 228       96.88    -67.14                                   
REMARK 500  8 SER A 235        4.19    -65.58                                   
REMARK 500  8 SER B   5      -84.30    -73.63                                   
REMARK 500  8 PRO B   7     -175.06    -57.19                                   
REMARK 500  8 PRO B   8     -132.01    -54.19                                   
REMARK 500  8 THR B   9       50.83    175.81                                   
REMARK 500  8 ALA B  10       97.67    -46.83                                   
REMARK 500  8 ASN B  23      -32.25    -38.30                                   
REMARK 500  8 THR B  31     -111.12    -55.67                                   
REMARK 500  8 SER B  32     -153.84   -152.01                                   
REMARK 500  8 LEU B  34       -7.08    -59.36                                   
REMARK 500  8 SER B  36       36.28    -74.08                                   
REMARK 500  8 GLN B  37       61.68   -169.91                                   
REMARK 500  8 PRO B  38     -162.06    -73.14                                   
REMARK 500  8 ALA B  39      176.93    173.96                                   
REMARK 500  8 THR B  44     -143.34   -138.59                                   
REMARK 500  8 SER B  47      -84.40   -147.06                                   
REMARK 500  8 ALA B  48      -90.35    156.08                                   
REMARK 500  8 LEU B  68      -77.62    -77.51                                   
REMARK 500  9 SER A   4       83.57   -164.16                                   
REMARK 500  9 GLN A   6      -33.90   -166.29                                   
REMARK 500  9 GLU A  18     -149.73    -67.32                                   
REMARK 500  9 GLU A  19      -68.87   -135.38                                   
REMARK 500  9 ASP A  36       28.62    -78.33                                   
REMARK 500  9 GLN A  37      -19.44   -141.05                                   
REMARK 500  9 PRO A  39      157.84    -40.00                                   
REMARK 500  9 LYS A  43       88.12    -67.47                                   
REMARK 500  9 SER A  47      159.34    177.48                                   
REMARK 500  9 SER A  54       -1.62    112.14                                   
REMARK 500  9 GLU A  55      -52.80    -28.97                                   
REMARK 500  9 SER A  56     -123.65     29.48                                   
REMARK 500  9 ASP A  57      -54.47   -171.65                                   
REMARK 500  9 PRO A  58     -104.66    -85.75                                   
REMARK 500  9 GLU A  61       52.96     70.74                                   
REMARK 500  9 VAL A  62       15.07   -148.78                                   
REMARK 500  9 GLU A  63       84.55    -41.14                                   
REMARK 500  9 SER A  64      108.16     48.64                                   
REMARK 500  9 GLU A  65       97.83     90.54                                   
REMARK 500  9 ASP A  67      171.66     59.75                                   
REMARK 500  9 THR A  69      -47.79     75.08                                   
REMARK 500  9 SER A  70      155.55    -44.00                                   
REMARK 500  9 GLU A  72       84.15     53.19                                   
REMARK 500  9 ASP A  75      -62.42   -178.64                                   
REMARK 500  9 PRO A  76       94.71    -27.82                                   
REMARK 500  9 SER A  82       62.66   -103.91                                   
REMARK 500  9 PRO A  98      129.95    -39.28                                   
REMARK 500  9 PRO A 121      163.81    -39.77                                   
REMARK 500  9 GLN A 123      -52.27   -139.31                                   
REMARK 500  9 GLU A 152       17.74   -162.45                                   
REMARK 500  9 ASP A 156      174.44    -50.09                                   
REMARK 500  9 LYS A 160     -160.88   -104.95                                   
REMARK 500  9 PRO A 163      158.62    -39.29                                   
REMARK 500  9 HIS A 171       35.92    -73.21                                   
REMARK 500  9 LYS A 172     -164.66    -59.21                                   
REMARK 500  9 SER A 175      149.25    -31.48                                   
REMARK 500  9 ASP A 178       96.29    -65.92                                   
REMARK 500  9 LYS A 188      -27.41    -37.55                                   
REMARK 500  9 CYS A 189       31.43   -146.17                                   
REMARK 500  9 LEU A 193      108.84   -174.07                                   
REMARK 500  9 GLU A 205      156.62    -48.28                                   
REMARK 500  9 GLU A 210      105.59   -163.80                                   
REMARK 500  9 LYS A 212      147.30   -171.38                                   
REMARK 500  9 ASP A 228       95.47    -57.91                                   
REMARK 500  9 ASP A 229       35.60    -89.20                                   
REMARK 500  9 LEU A 232      -37.22    -38.52                                   
REMARK 500  9 ALA A 240      171.32    -55.75                                   
REMARK 500  9 SER B   5      -88.14    -67.27                                   
REMARK 500  9 ASP B   6       59.17   -151.10                                   
REMARK 500  9 PRO B   8      172.59    -42.72                                   
REMARK 500  9 PRO B  21      151.04    -41.93                                   
REMARK 500  9 ASN B  23      -41.26    -28.99                                   
REMARK 500  9 PHE B  24       50.26   -109.60                                   
REMARK 500  9 VAL B  25       88.78   -150.22                                   
REMARK 500  9 THR B  31     -115.35    -55.92                                   
REMARK 500  9 SER B  32     -149.29   -147.84                                   
REMARK 500  9 SER B  36       37.97    -73.65                                   
REMARK 500  9 GLN B  37       64.30   -169.22                                   
REMARK 500  9 PRO B  38     -162.86    -75.95                                   
REMARK 500  9 ALA B  39      176.20    174.32                                   
REMARK 500  9 THR B  44     -140.86    -79.52                                   
REMARK 500  9 SER B  47      -84.95   -157.26                                   
REMARK 500  9 ALA B  48      -90.42    154.76                                   
REMARK 500  9 LEU B  68      -75.34    -76.21                                   
REMARK 500 10 ALA A   3      148.70   -171.57                                   
REMARK 500 10 SER A   4       12.50   -170.18                                   
REMARK 500 10 GLN A   6      -72.84   -166.48                                   
REMARK 500 10 GLU A  19      -65.72    -23.54                                   
REMARK 500 10 SER A  47      154.12    173.14                                   
REMARK 500 10 GLU A  53      171.57    -52.96                                   
REMARK 500 10 SER A  56      115.30    -33.59                                   
REMARK 500 10 PRO A  58       -5.53    -45.79                                   
REMARK 500 10 ASP A  59      -50.68   -177.53                                   
REMARK 500 10 PRO A  60     -143.05    -59.11                                   
REMARK 500 10 GLU A  61      160.23     91.47                                   
REMARK 500 10 VAL A  62     -104.63   -143.50                                   
REMARK 500 10 SER A  64      130.78     82.99                                   
REMARK 500 10 ASP A  67      -94.84    -87.68                                   
REMARK 500 10 THR A  69       80.72     50.43                                   
REMARK 500 10 VAL A  71       37.40   -160.97                                   
REMARK 500 10 GLU A  72       41.64    -97.44                                   
REMARK 500 10 PRO A  76      157.52    -38.90                                   
REMARK 500 10 PRO A  77     -170.01    -67.97                                   
REMARK 500 10 PHE A  92     -164.91   -116.27                                   
REMARK 500 10 PRO A  98      153.51    -34.91                                   
REMARK 500 10 LYS A 101      -12.05   -147.21                                   
REMARK 500 10 SER A 127       61.03   -155.04                                   
REMARK 500 10 ASP A 147       85.76   -166.10                                   
REMARK 500 10 ASP A 156      171.79    -52.16                                   
REMARK 500 10 PRO A 163      159.92    -39.42                                   
REMARK 500 10 ASN A 168        9.93     58.08                                   
REMARK 500 10 HIS A 171       43.95    -74.95                                   
REMARK 500 10 LYS A 188      -30.41    -39.21                                   
REMARK 500 10 CYS A 189       26.43   -143.95                                   
REMARK 500 10 ARG A 198      112.30   -171.25                                   
REMARK 500 10 SER A 207      -39.37    -35.58                                   
REMARK 500 10 SER A 223      129.81   -170.87                                   
REMARK 500 10 ASP A 228       99.61    -61.64                                   
REMARK 500 10 SER A 235       -0.05    -56.78                                   
REMARK 500 10 SER B   5      -84.65    -72.61                                   
REMARK 500 10 PRO B   8     -124.64    -51.37                                   
REMARK 500 10 THR B   9      -74.88   -170.59                                   
REMARK 500 10 ALA B  10       64.90     74.00                                   
REMARK 500 10 THR B  31     -109.79    -55.82                                   
REMARK 500 10 SER B  32     -147.96   -153.86                                   
REMARK 500 10 SER B  33      -32.43   -136.47                                   
REMARK 500 10 SER B  36       37.00    -72.58                                   
REMARK 500 10 GLN B  37       61.83   -171.27                                   
REMARK 500 10 PRO B  38     -167.66    -73.66                                   
REMARK 500 10 THR B  44     -145.82   -142.00                                   
REMARK 500 10 SER B  47      -83.78   -149.04                                   
REMARK 500 10 ALA B  48      -87.56    155.29                                   
REMARK 500 10 LEU B  68      -78.07    -78.63                                   
REMARK 500 11 SER A   4      -84.62    -68.26                                   
REMARK 500 11 LEU A   5      -75.90   -168.23                                   
REMARK 500 11 GLN A   6       79.13    -62.92                                   
REMARK 500 11 SER A   8      -33.73   -165.37                                   
REMARK 500 11 GLU A  18     -163.89    -61.24                                   
REMARK 500 11 GLU A  19      -73.01   -114.56                                   
REMARK 500 11 THR A  38      104.10    -40.30                                   
REMARK 500 11 PRO A  39      161.81    -43.87                                   
REMARK 500 11 ASN A  41       96.21   -165.30                                   
REMARK 500 11 LYS A  43       82.53    -65.35                                   
REMARK 500 11 GLU A  53       84.85    -57.17                                   
REMARK 500 11 SER A  54       17.05   -145.55                                   
REMARK 500 11 SER A  56       30.90   -164.78                                   
REMARK 500 11 PRO A  58       86.36    -35.15                                   
REMARK 500 11 ASP A  59       64.50    164.12                                   
REMARK 500 11 VAL A  62      -27.28   -173.20                                   
REMARK 500 11 GLU A  63       30.23   -172.59                                   
REMARK 500 11 SER A  64     -177.61    177.73                                   
REMARK 500 11 ASP A  66     -127.31   -136.00                                   
REMARK 500 11 SER A  70       48.44    -76.52                                   
REMARK 500 11 GLU A  72      -33.78   -147.91                                   
REMARK 500 11 VAL A  74       46.06   -146.51                                   
REMARK 500 11 ASP A  75       66.80   -158.35                                   
REMARK 500 11 SER A  82       75.42   -152.53                                   
REMARK 500 11 PRO A  98      144.19    -34.39                                   
REMARK 500 11 LYS A 101      -15.96   -143.27                                   
REMARK 500 11 PRO A 121      163.75    -38.84                                   
REMARK 500 11 GLN A 123      -27.57   -152.89                                   
REMARK 500 11 SER A 127       67.13   -153.19                                   
REMARK 500 11 GLU A 154       -0.74   -144.54                                   
REMARK 500 11 THR A 161        0.43    -64.26                                   
REMARK 500 11 PRO A 163      157.49    -40.11                                   
REMARK 500 11 ASN A 168       -0.74     60.31                                   
REMARK 500 11 LYS A 172     -170.98    -59.63                                   
REMARK 500 11 SER A 175      143.68    -38.65                                   
REMARK 500 11 CYS A 189       16.75   -147.33                                   
REMARK 500 11 LEU A 193      105.84   -169.74                                   
REMARK 500 11 ARG A 198      108.91   -166.41                                   
REMARK 500 11 SER A 207      -75.63     58.39                                   
REMARK 500 11 ASP A 228       95.72    -62.55                                   
REMARK 500 11 ASP A 229       30.03    -87.27                                   
REMARK 500 11 SER A 235       -6.50    -56.60                                   
REMARK 500 11 ASP B   6       70.40     40.89                                   
REMARK 500 11 PRO B   8     -116.33    -36.11                                   
REMARK 500 11 THR B   9      -73.97    172.64                                   
REMARK 500 11 ALA B  10       63.98     80.00                                   
REMARK 500 11 ASN B  23       29.90    -69.67                                   
REMARK 500 11 PHE B  24       33.33   -155.45                                   
REMARK 500 11 THR B  31     -108.25    -51.45                                   
REMARK 500 11 LEU B  34      -13.14    -49.59                                   
REMARK 500 11 SER B  36       35.32    -76.44                                   
REMARK 500 11 GLN B  37       59.27   -163.98                                   
REMARK 500 11 PRO B  38     -164.57    -60.40                                   
REMARK 500 11 ALA B  39      176.69    176.14                                   
REMARK 500 11 SER B  47      -79.61   -158.47                                   
REMARK 500 11 ALA B  48      -90.54    155.80                                   
REMARK 500 11 LEU B  68      -74.75    -72.85                                   
REMARK 500 12 SER A   4       25.91   -166.37                                   
REMARK 500 12 LEU A   5      150.26     57.45                                   
REMARK 500 12 GLU A  18     -165.24    -67.64                                   
REMARK 500 12 GLU A  19      -75.92   -116.05                                   
REMARK 500 12 PRO A  39      157.80    -39.25                                   
REMARK 500 12 LYS A  43       83.80    -63.51                                   
REMARK 500 12 GLU A  53      176.58    -51.11                                   
REMARK 500 12 GLU A  55     -151.23    113.62                                   
REMARK 500 12 SER A  56      -66.53   -138.68                                   
REMARK 500 12 ASP A  59      -64.62    169.27                                   
REMARK 500 12 PRO A  60     -105.74    -24.05                                   
REMARK 500 12 GLU A  61       83.91     51.30                                   
REMARK 500 12 SER A  64       34.60   -162.18                                   
REMARK 500 12 GLU A  65       66.55   -171.37                                   
REMARK 500 12 ASP A  66       56.22   -171.27                                   
REMARK 500 12 ASP A  67       93.20    -69.24                                   
REMARK 500 12 SER A  68     -178.55    -63.25                                   
REMARK 500 12 THR A  69       27.27   -162.18                                   
REMARK 500 12 VAL A  71       59.09   -103.96                                   
REMARK 500 12 GLU A  72      -27.06   -165.82                                   
REMARK 500 12 VAL A  74     -135.77    -70.70                                   
REMARK 500 12 PRO A  76      106.05    -43.85                                   
REMARK 500 12 SER A  82       69.38   -103.45                                   
REMARK 500 12 PRO A  98      154.14    -40.06                                   
REMARK 500 12 PRO A 121      144.68    -37.62                                   
REMARK 500 12 GLU A 152       11.40   -166.47                                   
REMARK 500 12 ASP A 156      173.11    -58.21                                   
REMARK 500 12 PRO A 163      154.47    -40.10                                   
REMARK 500 12 ASN A 168        5.25     57.60                                   
REMARK 500 12 HIS A 171       39.55    -83.13                                   
REMARK 500 12 LYS A 188      -28.87    -38.36                                   
REMARK 500 12 CYS A 189       29.39   -148.42                                   
REMARK 500 12 LEU A 193      106.65   -173.22                                   
REMARK 500 12 GLU A 205      158.71    -47.63                                   
REMARK 500 12 SER A 206       23.02   -143.38                                   
REMARK 500 12 SER A 207      -75.23     57.68                                   
REMARK 500 12 SER A 223      120.07   -174.97                                   
REMARK 500 12 ASP A 228       97.79    -57.32                                   
REMARK 500 12 ASP A 229       31.00    -93.26                                   
REMARK 500 12 PRO B   2     -107.92    -77.44                                   
REMARK 500 12 MET B   3       20.79    163.25                                   
REMARK 500 12 SER B   5      -97.23   -162.24                                   
REMARK 500 12 ASP B   6       61.99   -117.25                                   
REMARK 500 12 PRO B   8     -124.14    -38.65                                   
REMARK 500 12 THR B   9       67.67    159.30                                   
REMARK 500 12 ALA B  10      103.03    -56.73                                   
REMARK 500 12 PRO B  21      153.08    -42.04                                   
REMARK 500 12 ASN B  23      -35.50    -35.95                                   
REMARK 500 12 PHE B  24       43.23   -105.58                                   
REMARK 500 12 THR B  31     -111.40    -53.93                                   
REMARK 500 12 SER B  32     -148.68   -154.98                                   
REMARK 500 12 SER B  36       38.65    -73.31                                   
REMARK 500 12 GLN B  37       61.10   -164.29                                   
REMARK 500 12 PRO B  38     -161.82    -74.14                                   
REMARK 500 12 ALA B  39      176.53    170.76                                   
REMARK 500 12 THR B  44     -144.85   -138.17                                   
REMARK 500 12 SER B  47      -83.17   -152.83                                   
REMARK 500 12 ALA B  48      -86.78    155.29                                   
REMARK 500 12 LEU B  68      -83.57    -79.79                                   
REMARK 500 13 PRO A   2      104.69    -44.08                                   
REMARK 500 13 ALA A   3       85.78    -65.95                                   
REMARK 500 13 SER A   4       77.05    -68.93                                   
REMARK 500 13 LEU A   5     -161.48    -57.48                                   
REMARK 500 13 GLN A   6     -165.44     51.72                                   
REMARK 500 13 GLN A   7      159.49     58.16                                   
REMARK 500 13 SER A   8      -27.46   -163.06                                   
REMARK 500 13 GLU A  18     -167.32    -62.44                                   
REMARK 500 13 ASP A  36       43.21    -76.26                                   
REMARK 500 13 GLN A  37      -28.33   -152.30                                   
REMARK 500 13 PRO A  39      156.82    -38.47                                   
REMARK 500 13 LYS A  43       82.24    -69.00                                   
REMARK 500 13 CYS A  45       40.29     32.82                                   
REMARK 500 13 GLU A  53      171.33    -51.70                                   
REMARK 500 13 GLU A  55      158.36    -39.53                                   
REMARK 500 13 SER A  56     -103.38    -27.31                                   
REMARK 500 13 ASP A  57      153.56     55.27                                   
REMARK 500 13 PRO A  58       39.97    -74.60                                   
REMARK 500 13 ASP A  59       72.53   -174.03                                   
REMARK 500 13 VAL A  62      -34.70   -164.86                                   
REMARK 500 13 GLU A  63      124.85     71.88                                   
REMARK 500 13 SER A  64      105.86     69.77                                   
REMARK 500 13 ASP A  67      165.70    -41.86                                   
REMARK 500 13 SER A  68       88.85    -44.25                                   
REMARK 500 13 SER A  70     -119.32   -166.91                                   
REMARK 500 13 GLU A  72       96.95     47.88                                   
REMARK 500 13 ASP A  73       43.38   -157.71                                   
REMARK 500 13 PRO A  76      157.62    -37.18                                   
REMARK 500 13 SER A  82       69.38   -103.07                                   
REMARK 500 13 PRO A  98      162.13    -38.55                                   
REMARK 500 13 GLN A 123      -37.35   -141.24                                   
REMARK 500 13 SER A 127       63.42   -159.19                                   
REMARK 500 13 PRO A 163      147.94    -38.14                                   
REMARK 500 13 HIS A 171       28.22    -68.60                                   
REMARK 500 13 ASP A 178       95.19    -68.45                                   
REMARK 500 13 CYS A 189       36.23   -142.78                                   
REMARK 500 13 VAL A 190      105.09   -169.43                                   
REMARK 500 13 LEU A 193      106.60   -173.56                                   
REMARK 500 13 GLU A 205      156.17    -43.65                                   
REMARK 500 13 SER A 206       67.08   -156.86                                   
REMARK 500 13 SER A 207      -88.21     30.84                                   
REMARK 500 13 LYS A 212      146.67   -171.01                                   
REMARK 500 13 ASP A 228       95.64    -62.13                                   
REMARK 500 13 MET B   3      175.03    -51.66                                   
REMARK 500 13 SER B   5       20.85   -175.74                                   
REMARK 500 13 ASP B   6       70.73    148.31                                   
REMARK 500 13 PRO B   8     -110.40    -74.90                                   
REMARK 500 13 THR B   9       65.55    160.65                                   
REMARK 500 13 ALA B  10       84.86    -63.82                                   
REMARK 500 13 ASN B  23       26.31    -70.20                                   
REMARK 500 13 PHE B  24       27.42   -146.22                                   
REMARK 500 13 THR B  31     -108.57    -52.51                                   
REMARK 500 13 SER B  32     -149.45   -150.57                                   
REMARK 500 13 SER B  33      -24.60   -142.20                                   
REMARK 500 13 SER B  36       35.76    -72.61                                   
REMARK 500 13 GLN B  37       56.16   -155.04                                   
REMARK 500 13 PRO B  38     -167.86    -64.98                                   
REMARK 500 13 ALA B  39      176.57    173.21                                   
REMARK 500 13 THR B  44     -143.10   -140.08                                   
REMARK 500 13 SER B  47      -80.48   -156.09                                   
REMARK 500 13 ALA B  48      -90.20    154.72                                   
REMARK 500 13 LEU B  68      -84.51    -79.44                                   
REMARK 500 14 SER A   4       68.82   -169.66                                   
REMARK 500 14 LEU A   5      179.61     52.30                                   
REMARK 500 14 GLU A  19      -63.60    -23.51                                   
REMARK 500 14 ASN A  20       49.24    -76.68                                   
REMARK 500 14 MET A  24      174.76    -47.05                                   
REMARK 500 14 ASP A  36       40.99    -75.38                                   
REMARK 500 14 GLN A  37      -28.51   -145.30                                   
REMARK 500 14 PRO A  39      158.05    -40.29                                   
REMARK 500 14 GLU A  53      174.72    -56.27                                   
REMARK 500 14 ASP A  57       87.17   -156.00                                   
REMARK 500 14 GLU A  61      -96.79    -49.50                                   
REMARK 500 14 VAL A  62      -65.44    178.17                                   
REMARK 500 14 GLU A  63      -41.68   -173.05                                   
REMARK 500 14 SER A  64       88.24    -43.79                                   
REMARK 500 14 GLU A  65      105.06   -166.54                                   
REMARK 500 14 ASP A  67     -115.39    -59.03                                   
REMARK 500 14 THR A  69       22.92   -162.57                                   
REMARK 500 14 SER A  70     -177.68    165.15                                   
REMARK 500 14 VAL A  71       85.63     36.64                                   
REMARK 500 14 GLU A  72       -7.40    -54.98                                   
REMARK 500 14 ASP A  73       63.49   -100.01                                   
REMARK 500 14 PRO A  98      153.56    -40.47                                   
REMARK 500 14 SER A 127       68.33   -156.48                                   
REMARK 500 14 ASP A 147       79.97   -157.89                                   
REMARK 500 14 GLU A 152        7.14   -165.52                                   
REMARK 500 14 LYS A 155      155.93    -49.45                                   
REMARK 500 14 THR A 161       -0.92    -59.22                                   
REMARK 500 14 PRO A 163      154.60    -40.77                                   
REMARK 500 14 ASN A 168       -0.02     59.11                                   
REMARK 500 14 HIS A 171       31.86    -73.13                                   
REMARK 500 14 LYS A 172     -178.86    -64.61                                   
REMARK 500 14 LYS A 188      -36.47    -36.18                                   
REMARK 500 14 CYS A 189       32.74   -141.54                                   
REMARK 500 14 SER A 207      -76.03     52.93                                   
REMARK 500 14 LYS A 212      147.01   -170.23                                   
REMARK 500 14 SER A 223      116.77   -174.49                                   
REMARK 500 14 ASP A 228       95.87    -50.80                                   
REMARK 500 14 ASP A 229       35.55    -90.71                                   
REMARK 500 14 SER B   5      -86.61    -70.95                                   
REMARK 500 14 PRO B   7     -174.91    -59.38                                   
REMARK 500 14 PRO B   8     -131.85    -53.79                                   
REMARK 500 14 THR B   9       41.93    177.21                                   
REMARK 500 14 ALA B  10       93.26    -44.53                                   
REMARK 500 14 PRO B  21      150.09    -44.62                                   
REMARK 500 14 ASN B  23       27.66    -68.45                                   
REMARK 500 14 PHE B  24       27.30   -151.98                                   
REMARK 500 14 THR B  31     -107.29    -50.51                                   
REMARK 500 14 SER B  32     -132.93   -151.70                                   
REMARK 500 14 SER B  33      -25.28   -152.47                                   
REMARK 500 14 LEU B  34       -7.41    -57.70                                   
REMARK 500 14 SER B  36       35.54    -72.33                                   
REMARK 500 14 GLN B  37       61.71   -167.59                                   
REMARK 500 14 PRO B  38     -161.29    -73.94                                   
REMARK 500 14 ALA B  39      176.37    174.57                                   
REMARK 500 14 THR B  44     -145.99   -138.11                                   
REMARK 500 14 SER B  47      -79.23   -156.20                                   
REMARK 500 14 ALA B  48      -90.05    155.59                                   
REMARK 500 14 LEU B  68      -77.46    -76.77                                   
REMARK 500 15 ALA A   3       86.41     50.93                                   
REMARK 500 15 SER A   4       61.31   -166.28                                   
REMARK 500 15 LEU A   5     -177.47     50.70                                   
REMARK 500 15 GLN A   6       69.13   -170.02                                   
REMARK 500 15 SER A   8      -26.86     74.22                                   
REMARK 500 15 ILE A  30      110.67   -161.20                                   
REMARK 500 15 ASP A  36      -19.16    -46.77                                   
REMARK 500 15 ASN A  41       99.15   -167.09                                   
REMARK 500 15 LYS A  43       91.47    -67.87                                   
REMARK 500 15 SER A  47     -176.19   -174.20                                   
REMARK 500 15 VAL A  48      101.30   -170.36                                   
REMARK 500 15 GLU A  53      168.84    -48.00                                   
REMARK 500 15 SER A  56      -96.07    -27.15                                   
REMARK 500 15 ASP A  57      -33.15   -170.99                                   
REMARK 500 15 PRO A  58      -65.04    -90.62                                   
REMARK 500 15 ASP A  59      103.11    -40.73                                   
REMARK 500 15 GLU A  61       89.80    -62.29                                   
REMARK 500 15 VAL A  62       55.57     10.32                                   
REMARK 500 15 GLU A  63      172.75    -43.12                                   
REMARK 500 15 SER A  64       50.02    145.53                                   
REMARK 500 15 ASP A  66       62.25     69.85                                   
REMARK 500 15 ASP A  67     -122.23    -83.96                                   
REMARK 500 15 SER A  70     -162.56     50.70                                   
REMARK 500 15 VAL A  71       67.94   -153.71                                   
REMARK 500 15 GLU A  72       75.77     59.55                                   
REMARK 500 15 ASP A  73     -139.35    -76.86                                   
REMARK 500 15 ASP A  75       75.84     43.10                                   
REMARK 500 15 PRO A  98      143.51    -39.22                                   
REMARK 500 15 PRO A 121      158.27    -37.89                                   
REMARK 500 15 GLN A 123       -1.12   -140.99                                   
REMARK 500 15 SER A 127       60.72   -158.44                                   
REMARK 500 15 PRO A 128      143.81    -35.53                                   
REMARK 500 15 ASP A 147       83.37   -152.19                                   
REMARK 500 15 GLU A 152        6.06   -158.90                                   
REMARK 500 15 THR A 161        1.97    -62.55                                   
REMARK 500 15 PRO A 163      150.12    -40.39                                   
REMARK 500 15 ASN A 168        1.32     56.50                                   
REMARK 500 15 HIS A 171       46.34    -83.83                                   
REMARK 500 15 LYS A 188      -26.97    -39.82                                   
REMARK 500 15 CYS A 189       24.94   -146.31                                   
REMARK 500 15 LEU A 193      109.16   -172.88                                   
REMARK 500 15 CYS A 203      -61.74    -97.23                                   
REMARK 500 15 SER A 207      -36.97    -38.21                                   
REMARK 500 15 ASP A 219      -13.92     59.92                                   
REMARK 500 15 ASP A 228       95.80    -66.16                                   
REMARK 500 15 ASP B   6       96.96    -31.27                                   
REMARK 500 15 PRO B   8     -118.81    -34.61                                   
REMARK 500 15 THR B   9      -75.68    177.42                                   
REMARK 500 15 ALA B  10       57.00     80.72                                   
REMARK 500 15 ASN B  23       28.24    -69.77                                   
REMARK 500 15 PHE B  24       29.96   -153.12                                   
REMARK 500 15 THR B  31     -106.31    -53.92                                   
REMARK 500 15 SER B  32     -142.27   -157.70                                   
REMARK 500 15 SER B  33      -22.28   -145.65                                   
REMARK 500 15 LEU B  34       -7.46    -56.83                                   
REMARK 500 15 SER B  36       42.41    -74.55                                   
REMARK 500 15 GLN B  37       57.00   -167.69                                   
REMARK 500 15 PRO B  38     -164.20    -68.94                                   
REMARK 500 15 ALA B  39      176.82    175.59                                   
REMARK 500 15 THR B  44     -144.96   -135.60                                   
REMARK 500 15 ALA B  45      -38.82   -130.46                                   
REMARK 500 15 SER B  47      -81.02   -156.58                                   
REMARK 500 15 ALA B  48      -87.79    156.16                                   
REMARK 500 15 LEU B  68     -102.30    -85.20                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500  1 TYR A  80         0.07    SIDE_CHAIN                              
REMARK 500  1 ARG A  89         0.10    SIDE_CHAIN                              
REMARK 500  1 ARG A 115         0.32    SIDE_CHAIN                              
REMARK 500  1 ARG A 149         0.29    SIDE_CHAIN                              
REMARK 500  1 ARG B  18         0.31    SIDE_CHAIN                              
REMARK 500  1 ARG B  22         0.19    SIDE_CHAIN                              
REMARK 500  2 ARG A  89         0.09    SIDE_CHAIN                              
REMARK 500  2 ARG A 149         0.31    SIDE_CHAIN                              
REMARK 500  2 ARG A 198         0.10    SIDE_CHAIN                              
REMARK 500  2 ARG B  18         0.24    SIDE_CHAIN                              
REMARK 500  2 ARG B  22         0.20    SIDE_CHAIN                              
REMARK 500  3 ARG A  89         0.08    SIDE_CHAIN                              
REMARK 500  3 ARG A 115         0.15    SIDE_CHAIN                              
REMARK 500  3 ARG A 149         0.14    SIDE_CHAIN                              
REMARK 500  3 ARG A 198         0.29    SIDE_CHAIN                              
REMARK 500  3 ARG B  18         0.32    SIDE_CHAIN                              
REMARK 500  3 ARG B  22         0.25    SIDE_CHAIN                              
REMARK 500  4 ARG A  89         0.20    SIDE_CHAIN                              
REMARK 500  4 ARG A 115         0.25    SIDE_CHAIN                              
REMARK 500  4 ARG A 149         0.26    SIDE_CHAIN                              
REMARK 500  4 ARG A 198         0.31    SIDE_CHAIN                              
REMARK 500  4 ARG B  22         0.25    SIDE_CHAIN                              
REMARK 500  5 ARG A  89         0.16    SIDE_CHAIN                              
REMARK 500  5 ARG A 115         0.31    SIDE_CHAIN                              
REMARK 500  5 ARG A 149         0.21    SIDE_CHAIN                              
REMARK 500  5 ARG A 198         0.23    SIDE_CHAIN                              
REMARK 500  5 ARG B  18         0.30    SIDE_CHAIN                              
REMARK 500  6 ARG A  89         0.22    SIDE_CHAIN                              
REMARK 500  6 ARG A 115         0.32    SIDE_CHAIN                              
REMARK 500  6 ARG A 149         0.29    SIDE_CHAIN                              
REMARK 500  6 ARG B  18         0.32    SIDE_CHAIN                              
REMARK 500  6 ARG B  22         0.27    SIDE_CHAIN                              
REMARK 500  7 ARG A  89         0.31    SIDE_CHAIN                              
REMARK 500  7 ARG A 115         0.14    SIDE_CHAIN                              
REMARK 500  7 ARG A 149         0.20    SIDE_CHAIN                              
REMARK 500  7 ARG A 198         0.29    SIDE_CHAIN                              
REMARK 500  7 ARG B  18         0.28    SIDE_CHAIN                              
REMARK 500  7 ARG B  22         0.25    SIDE_CHAIN                              
REMARK 500  8 TYR A  80         0.09    SIDE_CHAIN                              
REMARK 500  8 ARG A  89         0.14    SIDE_CHAIN                              
REMARK 500  8 ARG A 149         0.27    SIDE_CHAIN                              
REMARK 500  8 ARG A 198         0.22    SIDE_CHAIN                              
REMARK 500  8 ARG B  18         0.27    SIDE_CHAIN                              
REMARK 500  9 ARG A  89         0.18    SIDE_CHAIN                              
REMARK 500  9 ARG A 149         0.32    SIDE_CHAIN                              
REMARK 500  9 ARG A 198         0.25    SIDE_CHAIN                              
REMARK 500  9 ARG B  18         0.11    SIDE_CHAIN                              
REMARK 500  9 ARG B  22         0.22    SIDE_CHAIN                              
REMARK 500 10 TYR A  80         0.07    SIDE_CHAIN                              
REMARK 500 10 ARG A  89         0.32    SIDE_CHAIN                              
REMARK 500 10 ARG A 115         0.22    SIDE_CHAIN                              
REMARK 500 10 ARG A 149         0.30    SIDE_CHAIN                              
REMARK 500 10 ARG A 198         0.30    SIDE_CHAIN                              
REMARK 500 10 ARG B  18         0.12    SIDE_CHAIN                              
REMARK 500 11 TYR A  81         0.08    SIDE_CHAIN                              
REMARK 500 11 ARG A  89         0.10    SIDE_CHAIN                              
REMARK 500 11 ARG A 115         0.14    SIDE_CHAIN                              
REMARK 500 11 ARG A 149         0.20    SIDE_CHAIN                              
REMARK 500 11 ARG A 198         0.29    SIDE_CHAIN                              
REMARK 500 11 ARG B  18         0.17    SIDE_CHAIN                              
REMARK 500 11 ARG B  22         0.32    SIDE_CHAIN                              
REMARK 500 12 ARG A  89         0.27    SIDE_CHAIN                              
REMARK 500 12 ARG A 115         0.13    SIDE_CHAIN                              
REMARK 500 12 ARG A 149         0.13    SIDE_CHAIN                              
REMARK 500 12 ARG A 198         0.32    SIDE_CHAIN                              
REMARK 500 12 ARG B  18         0.20    SIDE_CHAIN                              
REMARK 500 13 ARG A  89         0.24    SIDE_CHAIN                              
REMARK 500 13 ARG A 115         0.31    SIDE_CHAIN                              
REMARK 500 13 ARG A 149         0.15    SIDE_CHAIN                              
REMARK 500 13 ARG A 198         0.29    SIDE_CHAIN                              
REMARK 500 13 ARG B  18         0.27    SIDE_CHAIN                              
REMARK 500 13 ARG B  22         0.17    SIDE_CHAIN                              
REMARK 500 14 TYR A  81         0.06    SIDE_CHAIN                              
REMARK 500 14 ARG A  89         0.28    SIDE_CHAIN                              
REMARK 500 14 ARG A 149         0.31    SIDE_CHAIN                              
REMARK 500 14 ARG A 198         0.31    SIDE_CHAIN                              
REMARK 500 14 ARG B  18         0.17    SIDE_CHAIN                              
REMARK 500 14 ARG B  22         0.31    SIDE_CHAIN                              
REMARK 500 15 ARG A  89         0.13    SIDE_CHAIN                              
REMARK 500 15 ARG A 115         0.18    SIDE_CHAIN                              
REMARK 500 15 ARG A 149         0.31    SIDE_CHAIN                              
REMARK 500 15 ARG A 198         0.25    SIDE_CHAIN                              
REMARK 500 15 ARG B  18         0.09    SIDE_CHAIN                              
REMARK 500 15 ARG B  22         0.31    SIDE_CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 2FFK   RELATED DB: PDB                                   
DBREF  2FIN A    1   242  GB     44971547 AAS49897        17    258             
DBREF  2FIN B    1    69  UNP    P13236   CCL4_HUMAN      24     92             
SEQADV 2FIN ALA B   45  UNP  P13236    LYS    68 ENGINEERED                     
SEQADV 2FIN ALA B   46  UNP  P13236    ARG    69 ENGINEERED                     
SEQADV 2FIN ALA B   48  UNP  P13236    LYS    71 ENGINEERED                     
SEQRES   1 A  242  MET PRO ALA SER LEU GLN GLN SER SER SER SER SER SER          
SEQRES   2 A  242  SER CYS THR GLU GLU GLU ASN LYS HIS HIS MET GLY ILE          
SEQRES   3 A  242  ASP VAL ILE ILE LYS VAL THR LYS GLN ASP GLN THR PRO          
SEQRES   4 A  242  THR ASN ASP LYS ILE CYS GLN SER VAL THR GLU ILE THR          
SEQRES   5 A  242  GLU SER GLU SER ASP PRO ASP PRO GLU VAL GLU SER GLU          
SEQRES   6 A  242  ASP ASP SER THR SER VAL GLU ASP VAL ASP PRO PRO THR          
SEQRES   7 A  242  THR TYR TYR SER ILE ILE GLY GLY GLY LEU ARG MET ASN          
SEQRES   8 A  242  PHE GLY PHE THR LYS CYS PRO GLN ILE LYS SER ILE SER          
SEQRES   9 A  242  GLU SER ALA ASP GLY ASN THR VAL ASN ALA ARG LEU SER          
SEQRES  10 A  242  SER VAL SER PRO GLY GLN GLY LYS ASP SER PRO ALA ILE          
SEQRES  11 A  242  THR HIS GLU GLU ALA LEU ALA MET ILE LYS ASP CYS GLU          
SEQRES  12 A  242  VAL SER ILE ASP ILE ARG CYS SER GLU GLU GLU LYS ASP          
SEQRES  13 A  242  SER ASP ILE LYS THR HIS PRO VAL LEU GLY SER ASN ILE          
SEQRES  14 A  242  SER HIS LYS LYS VAL SER TYR GLU ASP ILE ILE GLY SER          
SEQRES  15 A  242  THR ILE VAL ASP THR LYS CYS VAL LYS ASN LEU GLU PHE          
SEQRES  16 A  242  SER VAL ARG ILE GLY ASP MET CYS LYS GLU SER SER GLU          
SEQRES  17 A  242  LEU GLU VAL LYS ASP GLY PHE LYS TYR VAL ASP GLY SER          
SEQRES  18 A  242  ALA SER LYS GLY ALA THR ASP ASP THR SER LEU ILE ASP          
SEQRES  19 A  242  SER THR LYS LEU LYS ALA CYS VAL                              
SEQRES   1 B   69  ALA PRO MET GLY SER ASP PRO PRO THR ALA CYS CYS PHE          
SEQRES   2 B   69  SER TYR THR ALA ARG LYS LEU PRO ARG ASN PHE VAL VAL          
SEQRES   3 B   69  ASP TYR TYR GLU THR SER SER LEU CYS SER GLN PRO ALA          
SEQRES   4 B   69  VAL VAL PHE GLN THR ALA ALA SER ALA GLN VAL CYS ALA          
SEQRES   5 B   69  ASP PRO SER GLU SER TRP VAL GLN GLU TYR VAL TYR ASP          
SEQRES   6 B   69  LEU GLU LEU ASN                                              
HELIX    1   1 HIS A  132  ASP A  141  1                                  10    
HELIX    2   2 SER B   57  LEU B   68  1                                  12    
SHEET    1   1 1 MET A  24  THR A  33  0                                        
SHEET    1   2 1 SER A  47  THR A  52  0                                        
SHEET    1   3 1 THR A  79  GLY A  85  0                                        
SHEET    1   4 1 LEU A  88  THR A  95  0                                        
SHEET    1   5 1 SER A 102  ASP A 108  0                                        
SHEET    1   6 1 THR A 111  SER A 117  0                                        
SHEET    1   7 1 GLU A 143  ARG A 149  0                                        
SHEET    1   8 1 GLY A 181  ASP A 186  0                                        
SHEET    1   9 1 ASN A 192  ASP A 201  0                                        
SHEET    1  10 1 VAL A 211  VAL A 218  0                                        
SHEET    1  11 1 SER A 221  SER A 223  0                                        
SHEET    1  12 1 ASP B  27  GLU B  30  0                                        
SHEET    1  13 1 VAL B  40  GLN B  43  0                                        
SHEET    1  14 1 GLN B  49  ALA B  52  0                                        
SSBOND   1 CYS A   15    CYS A  203                          1555   1555  2.02  
SSBOND   2 CYS A   45    CYS A  241                          1555   1555  2.02  
SSBOND   3 CYS A   97    CYS A  142                          1555   1555  2.02  
SSBOND   4 CYS A  150    CYS A  189                          1555   1555  2.02  
SSBOND   5 CYS B   11    CYS B   35                          1555   1555  2.03  
SSBOND   6 CYS B   12    CYS B   51                          1555   1555  2.02  
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
MODEL        1                                                                  
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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