HEADER CHAPERONE 14-NOV-06 2NWC
TITLE A 3.02 ANGSTROM CRYSTAL STRUCTURE OF WILD-TYPE APO GROEL IN A
TITLE 2 MONOCLINIC SPACE GROUP
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: 60 KDA CHAPERONIN;
COMPND 3 CHAIN: A, B, C, D, E, F, G, H, I, J, K, L, M, N;
COMPND 4 SYNONYM: PROTEIN CPN60, GROEL PROTEIN;
COMPND 5 EC: 3.6.4.9;
COMPND 6 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;
SOURCE 3 ORGANISM_TAXID: 562;
SOURCE 4 GENE: GROL, GROEL;
SOURCE 5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 6 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 7 EXPRESSION_SYSTEM_STRAIN: BL21 ROSETTA 2(DE3)PLYSS
KEYWDS CHAPERONIN, HSP60, CHAPERONE
EXPDTA X-RAY DIFFRACTION
AUTHOR P.D.KISER,D.T.LODOWSKI,K.PALCZEWSKI
REVDAT 4 30-AUG-23 2NWC 1 REMARK
REVDAT 3 24-FEB-09 2NWC 1 VERSN
REVDAT 2 26-JUN-07 2NWC 1 JRNL
REVDAT 1 22-MAY-07 2NWC 0
JRNL AUTH P.D.KISER,D.T.LODOWSKI,K.PALCZEWSKI
JRNL TITL PURIFICATION, CRYSTALLIZATION AND STRUCTURE DETERMINATION OF
JRNL TITL 2 NATIVE GROEL FROM ESCHERICHIA COLI LACKING BOUND POTASSIUM
JRNL TITL 3 IONS
JRNL REF ACTA CRYSTALLOGR.,SECT.F V. 63 457 2007
JRNL REFN ESSN 1744-3091
JRNL PMID 17554162
JRNL DOI 10.1107/S1744309107020295
REMARK 2
REMARK 2 RESOLUTION. 3.02 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 PROGRAM : REFMAC 5.2.0005
REMARK 3 AUTHORS : MURSHUDOV,SKUBAK,LEBEDEV,PANNU,STEINER,
REMARK 3 : NICHOLLS,WINN,LONG,VAGIN
REMARK 3
REMARK 3 REFINEMENT TARGET : MAXIMUM LIKELIHOOD
REMARK 3
REMARK 3 DATA USED IN REFINEMENT.
REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 3.02
REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 30.00
REMARK 3 DATA CUTOFF (SIGMA(F)) : NULL
REMARK 3 COMPLETENESS FOR RANGE (%) : 99.7
REMARK 3 NUMBER OF REFLECTIONS : 188012
REMARK 3
REMARK 3 FIT TO DATA USED IN REFINEMENT.
REMARK 3 CROSS-VALIDATION METHOD : THROUGHOUT
REMARK 3 FREE R VALUE TEST SET SELECTION : RANDOM
REMARK 3 R VALUE (WORKING + TEST SET) : 0.228
REMARK 3 R VALUE (WORKING SET) : 0.227
REMARK 3 FREE R VALUE : 0.263
REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.100
REMARK 3 FREE R VALUE TEST SET COUNT : 10042
REMARK 3
REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN.
REMARK 3 TOTAL NUMBER OF BINS USED : 20
REMARK 3 BIN RESOLUTION RANGE HIGH (A) : 3.02
REMARK 3 BIN RESOLUTION RANGE LOW (A) : 3.10
REMARK 3 REFLECTION IN BIN (WORKING SET) : 13658
REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : 98.92
REMARK 3 BIN R VALUE (WORKING SET) : 0.3480
REMARK 3 BIN FREE R VALUE SET COUNT : 758
REMARK 3 BIN FREE R VALUE : 0.3690
REMARK 3
REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.
REMARK 3 PROTEIN ATOMS : 53970
REMARK 3 NUCLEIC ACID ATOMS : 0
REMARK 3 HETEROGEN ATOMS : 0
REMARK 3 SOLVENT ATOMS : 0
REMARK 3
REMARK 3 B VALUES.
REMARK 3 FROM WILSON PLOT (A**2) : NULL
REMARK 3 MEAN B VALUE (OVERALL, A**2) : 70.40
REMARK 3 OVERALL ANISOTROPIC B VALUE.
REMARK 3 B11 (A**2) : -1.46000
REMARK 3 B22 (A**2) : -3.30000
REMARK 3 B33 (A**2) : 5.65000
REMARK 3 B12 (A**2) : 0.00000
REMARK 3 B13 (A**2) : 2.60000
REMARK 3 B23 (A**2) : 0.00000
REMARK 3
REMARK 3 ESTIMATED OVERALL COORDINATE ERROR.
REMARK 3 ESU BASED ON R VALUE (A): NULL
REMARK 3 ESU BASED ON FREE R VALUE (A): 0.433
REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD (A): 0.358
REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 44.905
REMARK 3
REMARK 3 CORRELATION COEFFICIENTS.
REMARK 3 CORRELATION COEFFICIENT FO-FC : 0.930
REMARK 3 CORRELATION COEFFICIENT FO-FC FREE : 0.904
REMARK 3
REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT
REMARK 3 BOND LENGTHS REFINED ATOMS (A): 54362 ; 0.006 ; 0.022
REMARK 3 BOND LENGTHS OTHERS (A): NULL ; NULL ; NULL
REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES): 73402 ; 0.971 ; 1.988
REMARK 3 BOND ANGLES OTHERS (DEGREES): NULL ; NULL ; NULL
REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES): 7322 ; 4.479 ; 5.000
REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES): 2100 ;39.520 ;26.067
REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES): 10080 ;17.461 ;15.000
REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES): 308 ;14.941 ;15.000
REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3): 8932 ; 0.066 ; 0.200
REMARK 3 GENERAL PLANES REFINED ATOMS (A): 39494 ; 0.002 ; 0.020
REMARK 3 GENERAL PLANES OTHERS (A): NULL ; NULL ; NULL
REMARK 3 NON-BONDED CONTACTS REFINED ATOMS (A): 25139 ; 0.184 ; 0.200
REMARK 3 NON-BONDED CONTACTS OTHERS (A): NULL ; NULL ; NULL
REMARK 3 NON-BONDED TORSION REFINED ATOMS (A): 38349 ; 0.288 ; 0.200
REMARK 3 NON-BONDED TORSION OTHERS (A): NULL ; NULL ; NULL
REMARK 3 H-BOND (X...Y) REFINED ATOMS (A): 1284 ; 0.111 ; 0.200
REMARK 3 H-BOND (X...Y) OTHERS (A): NULL ; NULL ; NULL
REMARK 3 POTENTIAL METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL
REMARK 3 POTENTIAL METAL-ION OTHERS (A): NULL ; NULL ; NULL
REMARK 3 SYMMETRY VDW REFINED ATOMS (A): 24 ; 0.213 ; 0.200
REMARK 3 SYMMETRY VDW OTHERS (A): NULL ; NULL ; NULL
REMARK 3 SYMMETRY H-BOND REFINED ATOMS (A): 6 ; 0.195 ; 0.200
REMARK 3 SYMMETRY H-BOND OTHERS (A): NULL ; NULL ; NULL
REMARK 3 SYMMETRY METAL-ION REFINED ATOMS (A): NULL ; NULL ; NULL
REMARK 3 SYMMETRY METAL-ION OTHERS (A): NULL ; NULL ; NULL
REMARK 3
REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT
REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2): 37177 ; 0.194 ; 1.500
REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2): NULL ; NULL ; NULL
REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 57876 ; 0.326 ; 2.000
REMARK 3 MAIN-CHAIN ANGLE OTHER ATOMS (A**2): NULL ; NULL ; NULL
REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2): 18651 ; 0.411 ; 3.000
REMARK 3 SIDE-CHAIN BOND OTHER ATOMS (A**2): NULL ; NULL ; NULL
REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2): 15526 ; 0.733 ; 4.500
REMARK 3 SIDE-CHAIN ANGLE OTHER ATOMS (A**2): NULL ; NULL ; NULL
REMARK 3 LONG RANGE B REFINED ATOMS (A**2): NULL ; NULL ; NULL
REMARK 3 LONG RANGE B OTHER ATOMS (A**2): NULL ; NULL ; NULL
REMARK 3
REMARK 3 ANISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT
REMARK 3 RIGID-BOND RESTRAINTS (A**2): NULL ; NULL ; NULL
REMARK 3 SPHERICITY; FREE ATOMS (A**2): NULL ; NULL ; NULL
REMARK 3 SPHERICITY; BONDED ATOMS (A**2): NULL ; NULL ; NULL
REMARK 3
REMARK 3 NCS RESTRAINTS STATISTICS
REMARK 3 NUMBER OF DIFFERENT NCS GROUPS : 2
REMARK 3
REMARK 3 NCS GROUP NUMBER : 1
REMARK 3 CHAIN NAMES : D A B C E F G
REMARK 3 NUMBER OF COMPONENTS NCS GROUP : 6
REMARK 3 COMPONENT C SSSEQI TO C SSSEQI CODE
REMARK 3 1 D 2 D 39 1
REMARK 3 1 A 2 A 39 1
REMARK 3 1 B 2 B 39 1
REMARK 3 1 C 2 C 39 1
REMARK 3 1 E 2 E 39 1
REMARK 3 1 F 2 F 39 1
REMARK 3 1 G 2 G 39 1
REMARK 3 2 D 40 D 46 6
REMARK 3 2 A 40 A 46 6
REMARK 3 2 B 40 B 46 6
REMARK 3 2 C 40 C 46 6
REMARK 3 2 E 40 E 46 6
REMARK 3 2 F 40 F 46 6
REMARK 3 2 G 40 G 46 6
REMARK 3 3 D 47 D 195 1
REMARK 3 3 A 47 A 195 1
REMARK 3 3 B 47 B 195 1
REMARK 3 3 C 47 C 195 1
REMARK 3 3 E 47 E 195 1
REMARK 3 3 F 47 F 195 1
REMARK 3 3 G 47 G 195 1
REMARK 3 4 D 196 D 224 6
REMARK 3 4 A 196 A 224 6
REMARK 3 4 B 196 B 224 6
REMARK 3 4 C 196 C 224 6
REMARK 3 4 E 196 E 224 6
REMARK 3 4 F 196 F 224 6
REMARK 3 4 G 196 G 224 6
REMARK 3 5 D 225 D 473 6
REMARK 3 5 A 225 A 473 6
REMARK 3 5 B 225 B 473 6
REMARK 3 5 C 225 C 473 6
REMARK 3 5 E 225 E 473 6
REMARK 3 5 F 225 F 473 6
REMARK 3 5 G 225 G 473 6
REMARK 3 6 D 489 D 525 1
REMARK 3 6 A 489 A 525 1
REMARK 3 6 B 489 B 525 1
REMARK 3 6 C 489 C 525 1
REMARK 3 6 E 489 E 525 1
REMARK 3 6 F 489 F 525 1
REMARK 3 6 G 489 G 525 1
REMARK 3 GROUP CHAIN COUNT RMS WEIGHT
REMARK 3 TIGHT POSITIONAL 1 D (A): 1619 ; 0.01 ; 0.05
REMARK 3 TIGHT POSITIONAL 1 A (A): 1619 ; 0.02 ; 0.05
REMARK 3 TIGHT POSITIONAL 1 B (A): 1619 ; 0.01 ; 0.05
REMARK 3 TIGHT POSITIONAL 1 C (A): 1619 ; 0.01 ; 0.05
REMARK 3 TIGHT POSITIONAL 1 E (A): 1619 ; 0.01 ; 0.05
REMARK 3 TIGHT POSITIONAL 1 F (A): 1619 ; 0.01 ; 0.05
REMARK 3 TIGHT POSITIONAL 1 G (A): 1619 ; 0.03 ; 0.05
REMARK 3 LOOSE POSITIONAL 1 D (A): 2121 ; 0.47 ; 5.00
REMARK 3 LOOSE POSITIONAL 1 A (A): 2121 ; 1.37 ; 5.00
REMARK 3 LOOSE POSITIONAL 1 B (A): 2121 ; 1.26 ; 5.00
REMARK 3 LOOSE POSITIONAL 1 C (A): 2121 ; 0.76 ; 5.00
REMARK 3 LOOSE POSITIONAL 1 E (A): 2121 ; 0.78 ; 5.00
REMARK 3 LOOSE POSITIONAL 1 F (A): 2121 ; 0.54 ; 5.00
REMARK 3 LOOSE POSITIONAL 1 G (A): 2121 ; 0.54 ; 5.00
REMARK 3 TIGHT THERMAL 1 D (A**2): 1619 ; 0.02 ; 0.50
REMARK 3 TIGHT THERMAL 1 A (A**2): 1619 ; 0.02 ; 0.50
REMARK 3 TIGHT THERMAL 1 B (A**2): 1619 ; 0.02 ; 0.50
REMARK 3 TIGHT THERMAL 1 C (A**2): 1619 ; 0.02 ; 0.50
REMARK 3 TIGHT THERMAL 1 E (A**2): 1619 ; 0.02 ; 0.50
REMARK 3 TIGHT THERMAL 1 F (A**2): 1619 ; 0.02 ; 0.50
REMARK 3 TIGHT THERMAL 1 G (A**2): 1619 ; 0.02 ; 0.50
REMARK 3 LOOSE THERMAL 1 D (A**2): 2121 ; 0.82 ; 10.00
REMARK 3 LOOSE THERMAL 1 A (A**2): 2121 ; 0.70 ; 10.00
REMARK 3 LOOSE THERMAL 1 B (A**2): 2121 ; 0.67 ; 10.00
REMARK 3 LOOSE THERMAL 1 C (A**2): 2121 ; 0.65 ; 10.00
REMARK 3 LOOSE THERMAL 1 E (A**2): 2121 ; 0.61 ; 10.00
REMARK 3 LOOSE THERMAL 1 F (A**2): 2121 ; 0.71 ; 10.00
REMARK 3 LOOSE THERMAL 1 G (A**2): 2121 ; 0.73 ; 10.00
REMARK 3
REMARK 3 NCS GROUP NUMBER : 2
REMARK 3 CHAIN NAMES : H N I J L M K
REMARK 3 NUMBER OF COMPONENTS NCS GROUP : 6
REMARK 3 COMPONENT C SSSEQI TO C SSSEQI CODE
REMARK 3 1 H 2 H 39 1
REMARK 3 1 N 2 N 39 1
REMARK 3 1 I 2 I 39 1
REMARK 3 1 J 2 J 39 1
REMARK 3 1 L 2 L 39 1
REMARK 3 1 M 2 M 39 1
REMARK 3 1 K 2 K 39 1
REMARK 3 2 H 40 H 46 6
REMARK 3 2 N 40 N 46 6
REMARK 3 2 I 40 I 46 6
REMARK 3 2 J 40 J 46 6
REMARK 3 2 L 40 L 46 6
REMARK 3 2 M 40 M 46 6
REMARK 3 2 K 40 K 46 6
REMARK 3 3 H 47 H 195 1
REMARK 3 3 N 47 N 195 1
REMARK 3 3 I 47 I 195 1
REMARK 3 3 J 47 J 195 1
REMARK 3 3 L 47 L 195 1
REMARK 3 3 M 47 M 195 1
REMARK 3 3 K 47 K 195 1
REMARK 3 4 H 196 H 224 6
REMARK 3 4 N 196 N 224 6
REMARK 3 4 I 196 I 224 6
REMARK 3 4 J 196 J 224 6
REMARK 3 4 L 196 L 224 6
REMARK 3 4 M 196 M 224 6
REMARK 3 4 K 196 K 224 6
REMARK 3 5 H 225 H 473 6
REMARK 3 5 N 225 N 473 6
REMARK 3 5 I 225 I 473 6
REMARK 3 5 J 225 J 473 6
REMARK 3 5 L 225 L 473 6
REMARK 3 5 M 225 M 473 6
REMARK 3 5 K 225 K 473 6
REMARK 3 6 H 489 H 525 1
REMARK 3 6 N 489 N 525 1
REMARK 3 6 I 489 I 525 1
REMARK 3 6 J 489 J 525 1
REMARK 3 6 L 489 L 525 1
REMARK 3 6 M 489 M 525 1
REMARK 3 6 K 489 K 525 1
REMARK 3 GROUP CHAIN COUNT RMS WEIGHT
REMARK 3 TIGHT POSITIONAL 2 H (A): 1619 ; 0.01 ; 0.05
REMARK 3 TIGHT POSITIONAL 2 N (A): 1619 ; 0.01 ; 0.05
REMARK 3 TIGHT POSITIONAL 2 I (A): 1619 ; 0.01 ; 0.05
REMARK 3 TIGHT POSITIONAL 2 J (A): 1619 ; 0.01 ; 0.05
REMARK 3 TIGHT POSITIONAL 2 L (A): 1619 ; 0.01 ; 0.05
REMARK 3 TIGHT POSITIONAL 2 M (A): 1619 ; 0.01 ; 0.05
REMARK 3 TIGHT POSITIONAL 2 K (A): 1619 ; 0.01 ; 0.05
REMARK 3 LOOSE POSITIONAL 2 H (A): 2121 ; 0.62 ; 5.00
REMARK 3 LOOSE POSITIONAL 2 N (A): 2121 ; 0.47 ; 5.00
REMARK 3 LOOSE POSITIONAL 2 I (A): 2121 ; 0.64 ; 5.00
REMARK 3 LOOSE POSITIONAL 2 J (A): 2121 ; 0.60 ; 5.00
REMARK 3 LOOSE POSITIONAL 2 L (A): 2121 ; 0.91 ; 5.00
REMARK 3 LOOSE POSITIONAL 2 M (A): 2121 ; 0.81 ; 5.00
REMARK 3 LOOSE POSITIONAL 2 K (A): 2121 ; 0.64 ; 5.00
REMARK 3 TIGHT THERMAL 2 H (A**2): 1619 ; 0.02 ; 0.50
REMARK 3 TIGHT THERMAL 2 N (A**2): 1619 ; 0.02 ; 0.50
REMARK 3 TIGHT THERMAL 2 I (A**2): 1619 ; 0.02 ; 0.50
REMARK 3 TIGHT THERMAL 2 J (A**2): 1619 ; 0.02 ; 0.50
REMARK 3 TIGHT THERMAL 2 L (A**2): 1619 ; 0.02 ; 0.50
REMARK 3 TIGHT THERMAL 2 M (A**2): 1619 ; 0.02 ; 0.50
REMARK 3 TIGHT THERMAL 2 K (A**2): 1619 ; 0.02 ; 0.50
REMARK 3 LOOSE THERMAL 2 H (A**2): 2121 ; 0.61 ; 10.00
REMARK 3 LOOSE THERMAL 2 N (A**2): 2121 ; 0.84 ; 10.00
REMARK 3 LOOSE THERMAL 2 I (A**2): 2121 ; 0.64 ; 10.00
REMARK 3 LOOSE THERMAL 2 J (A**2): 2121 ; 0.66 ; 10.00
REMARK 3 LOOSE THERMAL 2 L (A**2): 2121 ; 0.64 ; 10.00
REMARK 3 LOOSE THERMAL 2 M (A**2): 2121 ; 0.59 ; 10.00
REMARK 3 LOOSE THERMAL 2 K (A**2): 2121 ; 0.65 ; 10.00
REMARK 3
REMARK 3 TLS DETAILS
REMARK 3 NUMBER OF TLS GROUPS : NULL
REMARK 3
REMARK 3 BULK SOLVENT MODELLING.
REMARK 3 METHOD USED : MASK
REMARK 3 PARAMETERS FOR MASK CALCULATION
REMARK 3 VDW PROBE RADIUS : 1.20
REMARK 3 ION PROBE RADIUS : 0.80
REMARK 3 SHRINKAGE RADIUS : 0.80
REMARK 3
REMARK 3 OTHER REFINEMENT REMARKS: NULL
REMARK 4
REMARK 4 2NWC COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 16-NOV-06.
REMARK 100 THE DEPOSITION ID IS D_1000040382.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION
REMARK 200 DATE OF DATA COLLECTION : 16-APR-06
REMARK 200 TEMPERATURE (KELVIN) : 100
REMARK 200 PH : 8.0
REMARK 200 NUMBER OF CRYSTALS USED : 1
REMARK 200
REMARK 200 SYNCHROTRON (Y/N) : Y
REMARK 200 RADIATION SOURCE : ALS
REMARK 200 BEAMLINE : 5.0.2
REMARK 200 X-RAY GENERATOR MODEL : NULL
REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M
REMARK 200 WAVELENGTH OR RANGE (A) : 0.97
REMARK 200 MONOCHROMATOR : NULL
REMARK 200 OPTICS : NULL
REMARK 200
REMARK 200 DETECTOR TYPE : CCD
REMARK 200 DETECTOR MANUFACTURER : ADSC QUANTUM 315
REMARK 200 INTENSITY-INTEGRATION SOFTWARE : HKL-2000
REMARK 200 DATA SCALING SOFTWARE : HKL-2000
REMARK 200
REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 202060
REMARK 200 RESOLUTION RANGE HIGH (A) : 3.020
REMARK 200 RESOLUTION RANGE LOW (A) : 50.000
REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200 COMPLETENESS FOR RANGE (%) : 99.7
REMARK 200 DATA REDUNDANCY : 3.800
REMARK 200 R MERGE (I) : NULL
REMARK 200 R SYM (I) : 0.08700
REMARK 200 <I/SIGMA(I)> FOR THE DATA SET : 9.8000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.02
REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 3.13
REMARK 200 COMPLETENESS FOR SHELL (%) : 98.9
REMARK 200 DATA REDUNDANCY IN SHELL : 3.60
REMARK 200 R MERGE FOR SHELL (I) : NULL
REMARK 200 R SYM FOR SHELL (I) : 0.75700
REMARK 200 <I/SIGMA(I)> FOR SHELL : 1.020
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT
REMARK 200 SOFTWARE USED: PHASER
REMARK 200 STARTING MODEL: PDB ENTRY 1KP8
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS (%): 61.95
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.23
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M IMIDAZOLE, 35% MPD, 0.2 M MGCL2,
REMARK 280 PH 8.0, VAPOR DIFFUSION, TEMPERATURE 277K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290 SYMOP SYMMETRY
REMARK 290 NNNMMM OPERATOR
REMARK 290 1555 X,Y,Z
REMARK 290 2555 -X,Y+1/2,-Z
REMARK 290
REMARK 290 WHERE NNN -> OPERATOR NUMBER
REMARK 290 MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000
REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000
REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000
REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 0.00000
REMARK 290 SMTRY2 2 0.000000 1.000000 0.000000 131.12700
REMARK 290 SMTRY3 2 0.000000 0.000000 -1.000000 0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 300 REMARK: BIOLOGICAL ASSEMBLY IS IDENTICAL TO THAT OF DEPOSITED
REMARK 300 COORDINATES.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRADECAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRADECAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 51440 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 290000 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -218.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,
REMARK 350 AND CHAINS: K, L, M, N
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 LYS A 526
REMARK 465 ASN A 527
REMARK 465 ASP A 528
REMARK 465 ALA A 529
REMARK 465 ALA A 530
REMARK 465 ASP A 531
REMARK 465 LEU A 532
REMARK 465 GLY A 533
REMARK 465 ALA A 534
REMARK 465 ALA A 535
REMARK 465 GLY A 536
REMARK 465 GLY A 537
REMARK 465 MET A 538
REMARK 465 GLY A 539
REMARK 465 GLY A 540
REMARK 465 MET A 541
REMARK 465 GLY A 542
REMARK 465 GLY A 543
REMARK 465 MET A 544
REMARK 465 GLY A 545
REMARK 465 GLY A 546
REMARK 465 MET A 547
REMARK 465 MET A 548
REMARK 465 LYS B 526
REMARK 465 ASN B 527
REMARK 465 ASP B 528
REMARK 465 ALA B 529
REMARK 465 ALA B 530
REMARK 465 ASP B 531
REMARK 465 LEU B 532
REMARK 465 GLY B 533
REMARK 465 ALA B 534
REMARK 465 ALA B 535
REMARK 465 GLY B 536
REMARK 465 GLY B 537
REMARK 465 MET B 538
REMARK 465 GLY B 539
REMARK 465 GLY B 540
REMARK 465 MET B 541
REMARK 465 GLY B 542
REMARK 465 GLY B 543
REMARK 465 MET B 544
REMARK 465 GLY B 545
REMARK 465 GLY B 546
REMARK 465 MET B 547
REMARK 465 MET B 548
REMARK 465 LYS C 526
REMARK 465 ASN C 527
REMARK 465 ASP C 528
REMARK 465 ALA C 529
REMARK 465 ALA C 530
REMARK 465 ASP C 531
REMARK 465 LEU C 532
REMARK 465 GLY C 533
REMARK 465 ALA C 534
REMARK 465 ALA C 535
REMARK 465 GLY C 536
REMARK 465 GLY C 537
REMARK 465 MET C 538
REMARK 465 GLY C 539
REMARK 465 GLY C 540
REMARK 465 MET C 541
REMARK 465 GLY C 542
REMARK 465 GLY C 543
REMARK 465 MET C 544
REMARK 465 GLY C 545
REMARK 465 GLY C 546
REMARK 465 MET C 547
REMARK 465 MET C 548
REMARK 465 LYS D 526
REMARK 465 ASN D 527
REMARK 465 ASP D 528
REMARK 465 ALA D 529
REMARK 465 ALA D 530
REMARK 465 ASP D 531
REMARK 465 LEU D 532
REMARK 465 GLY D 533
REMARK 465 ALA D 534
REMARK 465 ALA D 535
REMARK 465 GLY D 536
REMARK 465 GLY D 537
REMARK 465 MET D 538
REMARK 465 GLY D 539
REMARK 465 GLY D 540
REMARK 465 MET D 541
REMARK 465 GLY D 542
REMARK 465 GLY D 543
REMARK 465 MET D 544
REMARK 465 GLY D 545
REMARK 465 GLY D 546
REMARK 465 MET D 547
REMARK 465 MET D 548
REMARK 465 LYS E 526
REMARK 465 ASN E 527
REMARK 465 ASP E 528
REMARK 465 ALA E 529
REMARK 465 ALA E 530
REMARK 465 ASP E 531
REMARK 465 LEU E 532
REMARK 465 GLY E 533
REMARK 465 ALA E 534
REMARK 465 ALA E 535
REMARK 465 GLY E 536
REMARK 465 GLY E 537
REMARK 465 MET E 538
REMARK 465 GLY E 539
REMARK 465 GLY E 540
REMARK 465 MET E 541
REMARK 465 GLY E 542
REMARK 465 GLY E 543
REMARK 465 MET E 544
REMARK 465 GLY E 545
REMARK 465 GLY E 546
REMARK 465 MET E 547
REMARK 465 MET E 548
REMARK 465 LYS F 526
REMARK 465 ASN F 527
REMARK 465 ASP F 528
REMARK 465 ALA F 529
REMARK 465 ALA F 530
REMARK 465 ASP F 531
REMARK 465 LEU F 532
REMARK 465 GLY F 533
REMARK 465 ALA F 534
REMARK 465 ALA F 535
REMARK 465 GLY F 536
REMARK 465 GLY F 537
REMARK 465 MET F 538
REMARK 465 GLY F 539
REMARK 465 GLY F 540
REMARK 465 MET F 541
REMARK 465 GLY F 542
REMARK 465 GLY F 543
REMARK 465 MET F 544
REMARK 465 GLY F 545
REMARK 465 GLY F 546
REMARK 465 MET F 547
REMARK 465 MET F 548
REMARK 465 LYS G 526
REMARK 465 ASN G 527
REMARK 465 ASP G 528
REMARK 465 ALA G 529
REMARK 465 ALA G 530
REMARK 465 ASP G 531
REMARK 465 LEU G 532
REMARK 465 GLY G 533
REMARK 465 ALA G 534
REMARK 465 ALA G 535
REMARK 465 GLY G 536
REMARK 465 GLY G 537
REMARK 465 MET G 538
REMARK 465 GLY G 539
REMARK 465 GLY G 540
REMARK 465 MET G 541
REMARK 465 GLY G 542
REMARK 465 GLY G 543
REMARK 465 MET G 544
REMARK 465 GLY G 545
REMARK 465 GLY G 546
REMARK 465 MET G 547
REMARK 465 MET G 548
REMARK 465 LYS H 526
REMARK 465 ASN H 527
REMARK 465 ASP H 528
REMARK 465 ALA H 529
REMARK 465 ALA H 530
REMARK 465 ASP H 531
REMARK 465 LEU H 532
REMARK 465 GLY H 533
REMARK 465 ALA H 534
REMARK 465 ALA H 535
REMARK 465 GLY H 536
REMARK 465 GLY H 537
REMARK 465 MET H 538
REMARK 465 GLY H 539
REMARK 465 GLY H 540
REMARK 465 MET H 541
REMARK 465 GLY H 542
REMARK 465 GLY H 543
REMARK 465 MET H 544
REMARK 465 GLY H 545
REMARK 465 GLY H 546
REMARK 465 MET H 547
REMARK 465 MET H 548
REMARK 465 LYS I 526
REMARK 465 ASN I 527
REMARK 465 ASP I 528
REMARK 465 ALA I 529
REMARK 465 ALA I 530
REMARK 465 ASP I 531
REMARK 465 LEU I 532
REMARK 465 GLY I 533
REMARK 465 ALA I 534
REMARK 465 ALA I 535
REMARK 465 GLY I 536
REMARK 465 GLY I 537
REMARK 465 MET I 538
REMARK 465 GLY I 539
REMARK 465 GLY I 540
REMARK 465 MET I 541
REMARK 465 GLY I 542
REMARK 465 GLY I 543
REMARK 465 MET I 544
REMARK 465 GLY I 545
REMARK 465 GLY I 546
REMARK 465 MET I 547
REMARK 465 MET I 548
REMARK 465 LYS J 526
REMARK 465 ASN J 527
REMARK 465 ASP J 528
REMARK 465 ALA J 529
REMARK 465 ALA J 530
REMARK 465 ASP J 531
REMARK 465 LEU J 532
REMARK 465 GLY J 533
REMARK 465 ALA J 534
REMARK 465 ALA J 535
REMARK 465 GLY J 536
REMARK 465 GLY J 537
REMARK 465 MET J 538
REMARK 465 GLY J 539
REMARK 465 GLY J 540
REMARK 465 MET J 541
REMARK 465 GLY J 542
REMARK 465 GLY J 543
REMARK 465 MET J 544
REMARK 465 GLY J 545
REMARK 465 GLY J 546
REMARK 465 MET J 547
REMARK 465 MET J 548
REMARK 465 LYS K 526
REMARK 465 ASN K 527
REMARK 465 ASP K 528
REMARK 465 ALA K 529
REMARK 465 ALA K 530
REMARK 465 ASP K 531
REMARK 465 LEU K 532
REMARK 465 GLY K 533
REMARK 465 ALA K 534
REMARK 465 ALA K 535
REMARK 465 GLY K 536
REMARK 465 GLY K 537
REMARK 465 MET K 538
REMARK 465 GLY K 539
REMARK 465 GLY K 540
REMARK 465 MET K 541
REMARK 465 GLY K 542
REMARK 465 GLY K 543
REMARK 465 MET K 544
REMARK 465 GLY K 545
REMARK 465 GLY K 546
REMARK 465 MET K 547
REMARK 465 MET K 548
REMARK 465 LYS L 526
REMARK 465 ASN L 527
REMARK 465 ASP L 528
REMARK 465 ALA L 529
REMARK 465 ALA L 530
REMARK 465 ASP L 531
REMARK 465 LEU L 532
REMARK 465 GLY L 533
REMARK 465 ALA L 534
REMARK 465 ALA L 535
REMARK 465 GLY L 536
REMARK 465 GLY L 537
REMARK 465 MET L 538
REMARK 465 GLY L 539
REMARK 465 GLY L 540
REMARK 465 MET L 541
REMARK 465 GLY L 542
REMARK 465 GLY L 543
REMARK 465 MET L 544
REMARK 465 GLY L 545
REMARK 465 GLY L 546
REMARK 465 MET L 547
REMARK 465 MET L 548
REMARK 465 LYS M 526
REMARK 465 ASN M 527
REMARK 465 ASP M 528
REMARK 465 ALA M 529
REMARK 465 ALA M 530
REMARK 465 ASP M 531
REMARK 465 LEU M 532
REMARK 465 GLY M 533
REMARK 465 ALA M 534
REMARK 465 ALA M 535
REMARK 465 GLY M 536
REMARK 465 GLY M 537
REMARK 465 MET M 538
REMARK 465 GLY M 539
REMARK 465 GLY M 540
REMARK 465 MET M 541
REMARK 465 GLY M 542
REMARK 465 GLY M 543
REMARK 465 MET M 544
REMARK 465 GLY M 545
REMARK 465 GLY M 546
REMARK 465 MET M 547
REMARK 465 MET M 548
REMARK 465 LYS N 526
REMARK 465 ASN N 527
REMARK 465 ASP N 528
REMARK 465 ALA N 529
REMARK 465 ALA N 530
REMARK 465 ASP N 531
REMARK 465 LEU N 532
REMARK 465 GLY N 533
REMARK 465 ALA N 534
REMARK 465 ALA N 535
REMARK 465 GLY N 536
REMARK 465 GLY N 537
REMARK 465 MET N 538
REMARK 465 GLY N 539
REMARK 465 GLY N 540
REMARK 465 MET N 541
REMARK 465 GLY N 542
REMARK 465 GLY N 543
REMARK 465 MET N 544
REMARK 465 GLY N 545
REMARK 465 GLY N 546
REMARK 465 MET N 547
REMARK 465 MET N 548
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION
REMARK 500 GLU B 232 CD GLU B 232 OE1 0.109
REMARK 500 GLU B 232 CD GLU B 232 OE2 0.180
REMARK 500 LYS I 327 CE LYS I 327 NZ 0.214
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 SER E 43 N - CA - CB ANGL. DEV. = -19.6 DEGREES
REMARK 500 SER E 43 N - CA - C ANGL. DEV. = 24.0 DEGREES
REMARK 500 ARG G 18 CD - NE - CZ ANGL. DEV. = 11.1 DEGREES
REMARK 500 ARG G 18 NE - CZ - NH1 ANGL. DEV. = -9.3 DEGREES
REMARK 500 ARG G 18 NE - CZ - NH2 ANGL. DEV. = 8.8 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 LYS A 34 32.16 -97.35
REMARK 500 CYS A 138 77.28 -117.30
REMARK 500 SER A 139 -74.84 -75.23
REMARK 500 ASP A 196 40.88 -83.73
REMARK 500 LYS A 225 160.48 179.91
REMARK 500 ASP A 253 147.93 -174.68
REMARK 500 ILE A 270 -74.84 -62.82
REMARK 500 SER A 358 117.18 -174.72
REMARK 500 ASN A 479 98.89 -58.85
REMARK 500 GLU A 483 59.94 74.75
REMARK 500 LYS B 34 33.45 -96.58
REMARK 500 CYS B 138 77.82 -117.29
REMARK 500 SER B 139 -74.70 -75.60
REMARK 500 GLU B 257 20.97 -67.85
REMARK 500 ALA B 258 -43.71 -135.56
REMARK 500 ASP B 328 31.12 -152.47
REMARK 500 ASP B 334 74.00 58.61
REMARK 500 GLU B 355 -79.86 -96.99
REMARK 500 LYS C 34 32.56 -97.46
REMARK 500 CYS C 138 77.35 -117.55
REMARK 500 SER C 139 -74.88 -75.07
REMARK 500 PRO C 202 -161.72 -64.16
REMARK 500 TYR C 203 -5.13 63.86
REMARK 500 ARG C 322 144.16 -170.43
REMARK 500 ASP C 328 29.49 -148.83
REMARK 500 GLU C 483 76.65 35.26
REMARK 500 LYS D 34 32.86 -97.45
REMARK 500 CYS D 138 77.14 -116.89
REMARK 500 SER D 139 -73.98 -75.44
REMARK 500 ASP D 196 48.80 -89.83
REMARK 500 PRO D 202 -162.82 -64.61
REMARK 500 TYR D 203 -23.63 69.91
REMARK 500 ASP D 328 26.77 -147.08
REMARK 500 ASP D 334 68.69 62.16
REMARK 500 THR D 385 127.05 -172.41
REMARK 500 ASN D 479 93.92 -68.31
REMARK 500 LYS E 34 33.10 -97.43
REMARK 500 PHE E 44 97.96 166.21
REMARK 500 CYS E 138 76.77 -117.75
REMARK 500 SER E 139 -74.24 -74.93
REMARK 500 ASP E 196 45.44 -83.83
REMARK 500 ARG E 268 70.33 -115.70
REMARK 500 ILE E 270 -106.80 -1.58
REMARK 500 THR E 313 -154.61 -110.78
REMARK 500 ASP E 328 33.68 -150.76
REMARK 500 GLU E 483 70.05 48.59
REMARK 500 LYS F 34 32.16 -97.64
REMARK 500 CYS F 138 77.61 -117.91
REMARK 500 SER F 139 -74.71 -75.30
REMARK 500 PRO F 202 7.20 -67.47
REMARK 500
REMARK 500 THIS ENTRY HAS 118 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500 MODEL OMEGA
REMARK 500 GLY A 269 ILE A 270 -142.54
REMARK 500 GLY C 269 ILE C 270 -109.90
REMARK 500 ARG D 268 GLY D 269 144.95
REMARK 500 SER E 43 PHE E 44 -114.05
REMARK 500 GLY F 269 ILE F 270 -124.95
REMARK 500 GLY I 269 ILE I 270 -134.72
REMARK 500 GLY K 269 ILE K 270 -136.08
REMARK 500 GLY M 269 ILE M 270 -137.42
REMARK 500 ILE M 270 VAL M 271 141.96
REMARK 500 GLY N 269 ILE N 270 -149.68
REMARK 500
REMARK 500 REMARK: NULL
DBREF 2NWC A 2 548 UNP Q1R3B6 CH60_ECOUT 2 548
DBREF 2NWC B 2 548 UNP Q1R3B6 CH60_ECOUT 2 548
DBREF 2NWC C 2 548 UNP Q1R3B6 CH60_ECOUT 2 548
DBREF 2NWC D 2 548 UNP Q1R3B6 CH60_ECOUT 2 548
DBREF 2NWC E 2 548 UNP Q1R3B6 CH60_ECOUT 2 548
DBREF 2NWC F 2 548 UNP Q1R3B6 CH60_ECOUT 2 548
DBREF 2NWC G 2 548 UNP Q1R3B6 CH60_ECOUT 2 548
DBREF 2NWC H 2 548 UNP Q1R3B6 CH60_ECOUT 2 548
DBREF 2NWC I 2 548 UNP Q1R3B6 CH60_ECOUT 2 548
DBREF 2NWC J 2 548 UNP Q1R3B6 CH60_ECOUT 2 548
DBREF 2NWC K 2 548 UNP Q1R3B6 CH60_ECOUT 2 548
DBREF 2NWC L 2 548 UNP Q1R3B6 CH60_ECOUT 2 548
DBREF 2NWC M 2 548 UNP Q1R3B6 CH60_ECOUT 2 548
DBREF 2NWC N 2 548 UNP Q1R3B6 CH60_ECOUT 2 548
SEQRES 1 A 547 ALA ALA LYS ASP VAL LYS PHE GLY ASN ASP ALA ARG VAL
SEQRES 2 A 547 LYS MET LEU ARG GLY VAL ASN VAL LEU ALA ASP ALA VAL
SEQRES 3 A 547 LYS VAL THR LEU GLY PRO LYS GLY ARG ASN VAL VAL LEU
SEQRES 4 A 547 ASP LYS SER PHE GLY ALA PRO THR ILE THR LYS ASP GLY
SEQRES 5 A 547 VAL SER VAL ALA ARG GLU ILE GLU LEU GLU ASP LYS PHE
SEQRES 6 A 547 GLU ASN MET GLY ALA GLN MET VAL LYS GLU VAL ALA SER
SEQRES 7 A 547 LYS ALA ASN ASP ALA ALA GLY ASP GLY THR THR THR ALA
SEQRES 8 A 547 THR VAL LEU ALA GLN ALA ILE ILE THR GLU GLY LEU LYS
SEQRES 9 A 547 ALA VAL ALA ALA GLY MET ASN PRO MET ASP LEU LYS ARG
SEQRES 10 A 547 GLY ILE ASP LYS ALA VAL THR ALA ALA VAL GLU GLU LEU
SEQRES 11 A 547 LYS ALA LEU SER VAL PRO CYS SER ASP SER LYS ALA ILE
SEQRES 12 A 547 ALA GLN VAL GLY THR ILE SER ALA ASN SER ASP GLU THR
SEQRES 13 A 547 VAL GLY LYS LEU ILE ALA GLU ALA MET ASP LYS VAL GLY
SEQRES 14 A 547 LYS GLU GLY VAL ILE THR VAL GLU ASP GLY THR GLY LEU
SEQRES 15 A 547 GLN ASP GLU LEU ASP VAL VAL GLU GLY MET GLN PHE ASP
SEQRES 16 A 547 ARG GLY TYR LEU SER PRO TYR PHE ILE ASN LYS PRO GLU
SEQRES 17 A 547 THR GLY ALA VAL GLU LEU GLU SER PRO PHE ILE LEU LEU
SEQRES 18 A 547 ALA ASP LYS LYS ILE SER ASN ILE ARG GLU MET LEU PRO
SEQRES 19 A 547 VAL LEU GLU ALA VAL ALA LYS ALA GLY LYS PRO LEU LEU
SEQRES 20 A 547 ILE ILE ALA GLU ASP VAL GLU GLY GLU ALA LEU ALA THR
SEQRES 21 A 547 LEU VAL VAL ASN THR MET ARG GLY ILE VAL LYS VAL ALA
SEQRES 22 A 547 ALA VAL LYS ALA PRO GLY PHE GLY ASP ARG ARG LYS ALA
SEQRES 23 A 547 MET LEU GLN ASP ILE ALA THR LEU THR GLY GLY THR VAL
SEQRES 24 A 547 ILE SER GLU GLU ILE GLY MET GLU LEU GLU LYS ALA THR
SEQRES 25 A 547 LEU GLU ASP LEU GLY GLN ALA LYS ARG VAL VAL ILE ASN
SEQRES 26 A 547 LYS ASP THR THR THR ILE ILE ASP GLY VAL GLY GLU GLU
SEQRES 27 A 547 ALA ALA ILE GLN GLY ARG VAL ALA GLN ILE ARG GLN GLN
SEQRES 28 A 547 ILE GLU GLU ALA THR SER ASP TYR ASP ARG GLU LYS LEU
SEQRES 29 A 547 GLN GLU ARG VAL ALA LYS LEU ALA GLY GLY VAL ALA VAL
SEQRES 30 A 547 ILE LYS VAL GLY ALA ALA THR GLU VAL GLU MET LYS GLU
SEQRES 31 A 547 LYS LYS ALA ARG VAL GLU ASP ALA LEU HIS ALA THR ARG
SEQRES 32 A 547 ALA ALA VAL GLU GLU GLY VAL VAL ALA GLY GLY GLY VAL
SEQRES 33 A 547 ALA LEU ILE ARG VAL ALA SER LYS LEU ALA ASP LEU ARG
SEQRES 34 A 547 GLY GLN ASN GLU ASP GLN ASN VAL GLY ILE LYS VAL ALA
SEQRES 35 A 547 LEU ARG ALA MET GLU ALA PRO LEU ARG GLN ILE VAL LEU
SEQRES 36 A 547 ASN CYS GLY GLU GLU PRO SER VAL VAL ALA ASN THR VAL
SEQRES 37 A 547 LYS GLY GLY ASP GLY ASN TYR GLY TYR ASN ALA ALA THR
SEQRES 38 A 547 GLU GLU TYR GLY ASN MET ILE ASP MET GLY ILE LEU ASP
SEQRES 39 A 547 PRO THR LYS VAL THR ARG SER ALA LEU GLN TYR ALA ALA
SEQRES 40 A 547 SER VAL ALA GLY LEU MET ILE THR THR GLU CYS MET VAL
SEQRES 41 A 547 THR ASP LEU PRO LYS ASN ASP ALA ALA ASP LEU GLY ALA
SEQRES 42 A 547 ALA GLY GLY MET GLY GLY MET GLY GLY MET GLY GLY MET
SEQRES 43 A 547 MET
SEQRES 1 B 547 ALA ALA LYS ASP VAL LYS PHE GLY ASN ASP ALA ARG VAL
SEQRES 2 B 547 LYS MET LEU ARG GLY VAL ASN VAL LEU ALA ASP ALA VAL
SEQRES 3 B 547 LYS VAL THR LEU GLY PRO LYS GLY ARG ASN VAL VAL LEU
SEQRES 4 B 547 ASP LYS SER PHE GLY ALA PRO THR ILE THR LYS ASP GLY
SEQRES 5 B 547 VAL SER VAL ALA ARG GLU ILE GLU LEU GLU ASP LYS PHE
SEQRES 6 B 547 GLU ASN MET GLY ALA GLN MET VAL LYS GLU VAL ALA SER
SEQRES 7 B 547 LYS ALA ASN ASP ALA ALA GLY ASP GLY THR THR THR ALA
SEQRES 8 B 547 THR VAL LEU ALA GLN ALA ILE ILE THR GLU GLY LEU LYS
SEQRES 9 B 547 ALA VAL ALA ALA GLY MET ASN PRO MET ASP LEU LYS ARG
SEQRES 10 B 547 GLY ILE ASP LYS ALA VAL THR ALA ALA VAL GLU GLU LEU
SEQRES 11 B 547 LYS ALA LEU SER VAL PRO CYS SER ASP SER LYS ALA ILE
SEQRES 12 B 547 ALA GLN VAL GLY THR ILE SER ALA ASN SER ASP GLU THR
SEQRES 13 B 547 VAL GLY LYS LEU ILE ALA GLU ALA MET ASP LYS VAL GLY
SEQRES 14 B 547 LYS GLU GLY VAL ILE THR VAL GLU ASP GLY THR GLY LEU
SEQRES 15 B 547 GLN ASP GLU LEU ASP VAL VAL GLU GLY MET GLN PHE ASP
SEQRES 16 B 547 ARG GLY TYR LEU SER PRO TYR PHE ILE ASN LYS PRO GLU
SEQRES 17 B 547 THR GLY ALA VAL GLU LEU GLU SER PRO PHE ILE LEU LEU
SEQRES 18 B 547 ALA ASP LYS LYS ILE SER ASN ILE ARG GLU MET LEU PRO
SEQRES 19 B 547 VAL LEU GLU ALA VAL ALA LYS ALA GLY LYS PRO LEU LEU
SEQRES 20 B 547 ILE ILE ALA GLU ASP VAL GLU GLY GLU ALA LEU ALA THR
SEQRES 21 B 547 LEU VAL VAL ASN THR MET ARG GLY ILE VAL LYS VAL ALA
SEQRES 22 B 547 ALA VAL LYS ALA PRO GLY PHE GLY ASP ARG ARG LYS ALA
SEQRES 23 B 547 MET LEU GLN ASP ILE ALA THR LEU THR GLY GLY THR VAL
SEQRES 24 B 547 ILE SER GLU GLU ILE GLY MET GLU LEU GLU LYS ALA THR
SEQRES 25 B 547 LEU GLU ASP LEU GLY GLN ALA LYS ARG VAL VAL ILE ASN
SEQRES 26 B 547 LYS ASP THR THR THR ILE ILE ASP GLY VAL GLY GLU GLU
SEQRES 27 B 547 ALA ALA ILE GLN GLY ARG VAL ALA GLN ILE ARG GLN GLN
SEQRES 28 B 547 ILE GLU GLU ALA THR SER ASP TYR ASP ARG GLU LYS LEU
SEQRES 29 B 547 GLN GLU ARG VAL ALA LYS LEU ALA GLY GLY VAL ALA VAL
SEQRES 30 B 547 ILE LYS VAL GLY ALA ALA THR GLU VAL GLU MET LYS GLU
SEQRES 31 B 547 LYS LYS ALA ARG VAL GLU ASP ALA LEU HIS ALA THR ARG
SEQRES 32 B 547 ALA ALA VAL GLU GLU GLY VAL VAL ALA GLY GLY GLY VAL
SEQRES 33 B 547 ALA LEU ILE ARG VAL ALA SER LYS LEU ALA ASP LEU ARG
SEQRES 34 B 547 GLY GLN ASN GLU ASP GLN ASN VAL GLY ILE LYS VAL ALA
SEQRES 35 B 547 LEU ARG ALA MET GLU ALA PRO LEU ARG GLN ILE VAL LEU
SEQRES 36 B 547 ASN CYS GLY GLU GLU PRO SER VAL VAL ALA ASN THR VAL
SEQRES 37 B 547 LYS GLY GLY ASP GLY ASN TYR GLY TYR ASN ALA ALA THR
SEQRES 38 B 547 GLU GLU TYR GLY ASN MET ILE ASP MET GLY ILE LEU ASP
SEQRES 39 B 547 PRO THR LYS VAL THR ARG SER ALA LEU GLN TYR ALA ALA
SEQRES 40 B 547 SER VAL ALA GLY LEU MET ILE THR THR GLU CYS MET VAL
SEQRES 41 B 547 THR ASP LEU PRO LYS ASN ASP ALA ALA ASP LEU GLY ALA
SEQRES 42 B 547 ALA GLY GLY MET GLY GLY MET GLY GLY MET GLY GLY MET
SEQRES 43 B 547 MET
SEQRES 1 C 547 ALA ALA LYS ASP VAL LYS PHE GLY ASN ASP ALA ARG VAL
SEQRES 2 C 547 LYS MET LEU ARG GLY VAL ASN VAL LEU ALA ASP ALA VAL
SEQRES 3 C 547 LYS VAL THR LEU GLY PRO LYS GLY ARG ASN VAL VAL LEU
SEQRES 4 C 547 ASP LYS SER PHE GLY ALA PRO THR ILE THR LYS ASP GLY
SEQRES 5 C 547 VAL SER VAL ALA ARG GLU ILE GLU LEU GLU ASP LYS PHE
SEQRES 6 C 547 GLU ASN MET GLY ALA GLN MET VAL LYS GLU VAL ALA SER
SEQRES 7 C 547 LYS ALA ASN ASP ALA ALA GLY ASP GLY THR THR THR ALA
SEQRES 8 C 547 THR VAL LEU ALA GLN ALA ILE ILE THR GLU GLY LEU LYS
SEQRES 9 C 547 ALA VAL ALA ALA GLY MET ASN PRO MET ASP LEU LYS ARG
SEQRES 10 C 547 GLY ILE ASP LYS ALA VAL THR ALA ALA VAL GLU GLU LEU
SEQRES 11 C 547 LYS ALA LEU SER VAL PRO CYS SER ASP SER LYS ALA ILE
SEQRES 12 C 547 ALA GLN VAL GLY THR ILE SER ALA ASN SER ASP GLU THR
SEQRES 13 C 547 VAL GLY LYS LEU ILE ALA GLU ALA MET ASP LYS VAL GLY
SEQRES 14 C 547 LYS GLU GLY VAL ILE THR VAL GLU ASP GLY THR GLY LEU
SEQRES 15 C 547 GLN ASP GLU LEU ASP VAL VAL GLU GLY MET GLN PHE ASP
SEQRES 16 C 547 ARG GLY TYR LEU SER PRO TYR PHE ILE ASN LYS PRO GLU
SEQRES 17 C 547 THR GLY ALA VAL GLU LEU GLU SER PRO PHE ILE LEU LEU
SEQRES 18 C 547 ALA ASP LYS LYS ILE SER ASN ILE ARG GLU MET LEU PRO
SEQRES 19 C 547 VAL LEU GLU ALA VAL ALA LYS ALA GLY LYS PRO LEU LEU
SEQRES 20 C 547 ILE ILE ALA GLU ASP VAL GLU GLY GLU ALA LEU ALA THR
SEQRES 21 C 547 LEU VAL VAL ASN THR MET ARG GLY ILE VAL LYS VAL ALA
SEQRES 22 C 547 ALA VAL LYS ALA PRO GLY PHE GLY ASP ARG ARG LYS ALA
SEQRES 23 C 547 MET LEU GLN ASP ILE ALA THR LEU THR GLY GLY THR VAL
SEQRES 24 C 547 ILE SER GLU GLU ILE GLY MET GLU LEU GLU LYS ALA THR
SEQRES 25 C 547 LEU GLU ASP LEU GLY GLN ALA LYS ARG VAL VAL ILE ASN
SEQRES 26 C 547 LYS ASP THR THR THR ILE ILE ASP GLY VAL GLY GLU GLU
SEQRES 27 C 547 ALA ALA ILE GLN GLY ARG VAL ALA GLN ILE ARG GLN GLN
SEQRES 28 C 547 ILE GLU GLU ALA THR SER ASP TYR ASP ARG GLU LYS LEU
SEQRES 29 C 547 GLN GLU ARG VAL ALA LYS LEU ALA GLY GLY VAL ALA VAL
SEQRES 30 C 547 ILE LYS VAL GLY ALA ALA THR GLU VAL GLU MET LYS GLU
SEQRES 31 C 547 LYS LYS ALA ARG VAL GLU ASP ALA LEU HIS ALA THR ARG
SEQRES 32 C 547 ALA ALA VAL GLU GLU GLY VAL VAL ALA GLY GLY GLY VAL
SEQRES 33 C 547 ALA LEU ILE ARG VAL ALA SER LYS LEU ALA ASP LEU ARG
SEQRES 34 C 547 GLY GLN ASN GLU ASP GLN ASN VAL GLY ILE LYS VAL ALA
SEQRES 35 C 547 LEU ARG ALA MET GLU ALA PRO LEU ARG GLN ILE VAL LEU
SEQRES 36 C 547 ASN CYS GLY GLU GLU PRO SER VAL VAL ALA ASN THR VAL
SEQRES 37 C 547 LYS GLY GLY ASP GLY ASN TYR GLY TYR ASN ALA ALA THR
SEQRES 38 C 547 GLU GLU TYR GLY ASN MET ILE ASP MET GLY ILE LEU ASP
SEQRES 39 C 547 PRO THR LYS VAL THR ARG SER ALA LEU GLN TYR ALA ALA
SEQRES 40 C 547 SER VAL ALA GLY LEU MET ILE THR THR GLU CYS MET VAL
SEQRES 41 C 547 THR ASP LEU PRO LYS ASN ASP ALA ALA ASP LEU GLY ALA
SEQRES 42 C 547 ALA GLY GLY MET GLY GLY MET GLY GLY MET GLY GLY MET
SEQRES 43 C 547 MET
SEQRES 1 D 547 ALA ALA LYS ASP VAL LYS PHE GLY ASN ASP ALA ARG VAL
SEQRES 2 D 547 LYS MET LEU ARG GLY VAL ASN VAL LEU ALA ASP ALA VAL
SEQRES 3 D 547 LYS VAL THR LEU GLY PRO LYS GLY ARG ASN VAL VAL LEU
SEQRES 4 D 547 ASP LYS SER PHE GLY ALA PRO THR ILE THR LYS ASP GLY
SEQRES 5 D 547 VAL SER VAL ALA ARG GLU ILE GLU LEU GLU ASP LYS PHE
SEQRES 6 D 547 GLU ASN MET GLY ALA GLN MET VAL LYS GLU VAL ALA SER
SEQRES 7 D 547 LYS ALA ASN ASP ALA ALA GLY ASP GLY THR THR THR ALA
SEQRES 8 D 547 THR VAL LEU ALA GLN ALA ILE ILE THR GLU GLY LEU LYS
SEQRES 9 D 547 ALA VAL ALA ALA GLY MET ASN PRO MET ASP LEU LYS ARG
SEQRES 10 D 547 GLY ILE ASP LYS ALA VAL THR ALA ALA VAL GLU GLU LEU
SEQRES 11 D 547 LYS ALA LEU SER VAL PRO CYS SER ASP SER LYS ALA ILE
SEQRES 12 D 547 ALA GLN VAL GLY THR ILE SER ALA ASN SER ASP GLU THR
SEQRES 13 D 547 VAL GLY LYS LEU ILE ALA GLU ALA MET ASP LYS VAL GLY
SEQRES 14 D 547 LYS GLU GLY VAL ILE THR VAL GLU ASP GLY THR GLY LEU
SEQRES 15 D 547 GLN ASP GLU LEU ASP VAL VAL GLU GLY MET GLN PHE ASP
SEQRES 16 D 547 ARG GLY TYR LEU SER PRO TYR PHE ILE ASN LYS PRO GLU
SEQRES 17 D 547 THR GLY ALA VAL GLU LEU GLU SER PRO PHE ILE LEU LEU
SEQRES 18 D 547 ALA ASP LYS LYS ILE SER ASN ILE ARG GLU MET LEU PRO
SEQRES 19 D 547 VAL LEU GLU ALA VAL ALA LYS ALA GLY LYS PRO LEU LEU
SEQRES 20 D 547 ILE ILE ALA GLU ASP VAL GLU GLY GLU ALA LEU ALA THR
SEQRES 21 D 547 LEU VAL VAL ASN THR MET ARG GLY ILE VAL LYS VAL ALA
SEQRES 22 D 547 ALA VAL LYS ALA PRO GLY PHE GLY ASP ARG ARG LYS ALA
SEQRES 23 D 547 MET LEU GLN ASP ILE ALA THR LEU THR GLY GLY THR VAL
SEQRES 24 D 547 ILE SER GLU GLU ILE GLY MET GLU LEU GLU LYS ALA THR
SEQRES 25 D 547 LEU GLU ASP LEU GLY GLN ALA LYS ARG VAL VAL ILE ASN
SEQRES 26 D 547 LYS ASP THR THR THR ILE ILE ASP GLY VAL GLY GLU GLU
SEQRES 27 D 547 ALA ALA ILE GLN GLY ARG VAL ALA GLN ILE ARG GLN GLN
SEQRES 28 D 547 ILE GLU GLU ALA THR SER ASP TYR ASP ARG GLU LYS LEU
SEQRES 29 D 547 GLN GLU ARG VAL ALA LYS LEU ALA GLY GLY VAL ALA VAL
SEQRES 30 D 547 ILE LYS VAL GLY ALA ALA THR GLU VAL GLU MET LYS GLU
SEQRES 31 D 547 LYS LYS ALA ARG VAL GLU ASP ALA LEU HIS ALA THR ARG
SEQRES 32 D 547 ALA ALA VAL GLU GLU GLY VAL VAL ALA GLY GLY GLY VAL
SEQRES 33 D 547 ALA LEU ILE ARG VAL ALA SER LYS LEU ALA ASP LEU ARG
SEQRES 34 D 547 GLY GLN ASN GLU ASP GLN ASN VAL GLY ILE LYS VAL ALA
SEQRES 35 D 547 LEU ARG ALA MET GLU ALA PRO LEU ARG GLN ILE VAL LEU
SEQRES 36 D 547 ASN CYS GLY GLU GLU PRO SER VAL VAL ALA ASN THR VAL
SEQRES 37 D 547 LYS GLY GLY ASP GLY ASN TYR GLY TYR ASN ALA ALA THR
SEQRES 38 D 547 GLU GLU TYR GLY ASN MET ILE ASP MET GLY ILE LEU ASP
SEQRES 39 D 547 PRO THR LYS VAL THR ARG SER ALA LEU GLN TYR ALA ALA
SEQRES 40 D 547 SER VAL ALA GLY LEU MET ILE THR THR GLU CYS MET VAL
SEQRES 41 D 547 THR ASP LEU PRO LYS ASN ASP ALA ALA ASP LEU GLY ALA
SEQRES 42 D 547 ALA GLY GLY MET GLY GLY MET GLY GLY MET GLY GLY MET
SEQRES 43 D 547 MET
SEQRES 1 E 547 ALA ALA LYS ASP VAL LYS PHE GLY ASN ASP ALA ARG VAL
SEQRES 2 E 547 LYS MET LEU ARG GLY VAL ASN VAL LEU ALA ASP ALA VAL
SEQRES 3 E 547 LYS VAL THR LEU GLY PRO LYS GLY ARG ASN VAL VAL LEU
SEQRES 4 E 547 ASP LYS SER PHE GLY ALA PRO THR ILE THR LYS ASP GLY
SEQRES 5 E 547 VAL SER VAL ALA ARG GLU ILE GLU LEU GLU ASP LYS PHE
SEQRES 6 E 547 GLU ASN MET GLY ALA GLN MET VAL LYS GLU VAL ALA SER
SEQRES 7 E 547 LYS ALA ASN ASP ALA ALA GLY ASP GLY THR THR THR ALA
SEQRES 8 E 547 THR VAL LEU ALA GLN ALA ILE ILE THR GLU GLY LEU LYS
SEQRES 9 E 547 ALA VAL ALA ALA GLY MET ASN PRO MET ASP LEU LYS ARG
SEQRES 10 E 547 GLY ILE ASP LYS ALA VAL THR ALA ALA VAL GLU GLU LEU
SEQRES 11 E 547 LYS ALA LEU SER VAL PRO CYS SER ASP SER LYS ALA ILE
SEQRES 12 E 547 ALA GLN VAL GLY THR ILE SER ALA ASN SER ASP GLU THR
SEQRES 13 E 547 VAL GLY LYS LEU ILE ALA GLU ALA MET ASP LYS VAL GLY
SEQRES 14 E 547 LYS GLU GLY VAL ILE THR VAL GLU ASP GLY THR GLY LEU
SEQRES 15 E 547 GLN ASP GLU LEU ASP VAL VAL GLU GLY MET GLN PHE ASP
SEQRES 16 E 547 ARG GLY TYR LEU SER PRO TYR PHE ILE ASN LYS PRO GLU
SEQRES 17 E 547 THR GLY ALA VAL GLU LEU GLU SER PRO PHE ILE LEU LEU
SEQRES 18 E 547 ALA ASP LYS LYS ILE SER ASN ILE ARG GLU MET LEU PRO
SEQRES 19 E 547 VAL LEU GLU ALA VAL ALA LYS ALA GLY LYS PRO LEU LEU
SEQRES 20 E 547 ILE ILE ALA GLU ASP VAL GLU GLY GLU ALA LEU ALA THR
SEQRES 21 E 547 LEU VAL VAL ASN THR MET ARG GLY ILE VAL LYS VAL ALA
SEQRES 22 E 547 ALA VAL LYS ALA PRO GLY PHE GLY ASP ARG ARG LYS ALA
SEQRES 23 E 547 MET LEU GLN ASP ILE ALA THR LEU THR GLY GLY THR VAL
SEQRES 24 E 547 ILE SER GLU GLU ILE GLY MET GLU LEU GLU LYS ALA THR
SEQRES 25 E 547 LEU GLU ASP LEU GLY GLN ALA LYS ARG VAL VAL ILE ASN
SEQRES 26 E 547 LYS ASP THR THR THR ILE ILE ASP GLY VAL GLY GLU GLU
SEQRES 27 E 547 ALA ALA ILE GLN GLY ARG VAL ALA GLN ILE ARG GLN GLN
SEQRES 28 E 547 ILE GLU GLU ALA THR SER ASP TYR ASP ARG GLU LYS LEU
SEQRES 29 E 547 GLN GLU ARG VAL ALA LYS LEU ALA GLY GLY VAL ALA VAL
SEQRES 30 E 547 ILE LYS VAL GLY ALA ALA THR GLU VAL GLU MET LYS GLU
SEQRES 31 E 547 LYS LYS ALA ARG VAL GLU ASP ALA LEU HIS ALA THR ARG
SEQRES 32 E 547 ALA ALA VAL GLU GLU GLY VAL VAL ALA GLY GLY GLY VAL
SEQRES 33 E 547 ALA LEU ILE ARG VAL ALA SER LYS LEU ALA ASP LEU ARG
SEQRES 34 E 547 GLY GLN ASN GLU ASP GLN ASN VAL GLY ILE LYS VAL ALA
SEQRES 35 E 547 LEU ARG ALA MET GLU ALA PRO LEU ARG GLN ILE VAL LEU
SEQRES 36 E 547 ASN CYS GLY GLU GLU PRO SER VAL VAL ALA ASN THR VAL
SEQRES 37 E 547 LYS GLY GLY ASP GLY ASN TYR GLY TYR ASN ALA ALA THR
SEQRES 38 E 547 GLU GLU TYR GLY ASN MET ILE ASP MET GLY ILE LEU ASP
SEQRES 39 E 547 PRO THR LYS VAL THR ARG SER ALA LEU GLN TYR ALA ALA
SEQRES 40 E 547 SER VAL ALA GLY LEU MET ILE THR THR GLU CYS MET VAL
SEQRES 41 E 547 THR ASP LEU PRO LYS ASN ASP ALA ALA ASP LEU GLY ALA
SEQRES 42 E 547 ALA GLY GLY MET GLY GLY MET GLY GLY MET GLY GLY MET
SEQRES 43 E 547 MET
SEQRES 1 F 547 ALA ALA LYS ASP VAL LYS PHE GLY ASN ASP ALA ARG VAL
SEQRES 2 F 547 LYS MET LEU ARG GLY VAL ASN VAL LEU ALA ASP ALA VAL
SEQRES 3 F 547 LYS VAL THR LEU GLY PRO LYS GLY ARG ASN VAL VAL LEU
SEQRES 4 F 547 ASP LYS SER PHE GLY ALA PRO THR ILE THR LYS ASP GLY
SEQRES 5 F 547 VAL SER VAL ALA ARG GLU ILE GLU LEU GLU ASP LYS PHE
SEQRES 6 F 547 GLU ASN MET GLY ALA GLN MET VAL LYS GLU VAL ALA SER
SEQRES 7 F 547 LYS ALA ASN ASP ALA ALA GLY ASP GLY THR THR THR ALA
SEQRES 8 F 547 THR VAL LEU ALA GLN ALA ILE ILE THR GLU GLY LEU LYS
SEQRES 9 F 547 ALA VAL ALA ALA GLY MET ASN PRO MET ASP LEU LYS ARG
SEQRES 10 F 547 GLY ILE ASP LYS ALA VAL THR ALA ALA VAL GLU GLU LEU
SEQRES 11 F 547 LYS ALA LEU SER VAL PRO CYS SER ASP SER LYS ALA ILE
SEQRES 12 F 547 ALA GLN VAL GLY THR ILE SER ALA ASN SER ASP GLU THR
SEQRES 13 F 547 VAL GLY LYS LEU ILE ALA GLU ALA MET ASP LYS VAL GLY
SEQRES 14 F 547 LYS GLU GLY VAL ILE THR VAL GLU ASP GLY THR GLY LEU
SEQRES 15 F 547 GLN ASP GLU LEU ASP VAL VAL GLU GLY MET GLN PHE ASP
SEQRES 16 F 547 ARG GLY TYR LEU SER PRO TYR PHE ILE ASN LYS PRO GLU
SEQRES 17 F 547 THR GLY ALA VAL GLU LEU GLU SER PRO PHE ILE LEU LEU
SEQRES 18 F 547 ALA ASP LYS LYS ILE SER ASN ILE ARG GLU MET LEU PRO
SEQRES 19 F 547 VAL LEU GLU ALA VAL ALA LYS ALA GLY LYS PRO LEU LEU
SEQRES 20 F 547 ILE ILE ALA GLU ASP VAL GLU GLY GLU ALA LEU ALA THR
SEQRES 21 F 547 LEU VAL VAL ASN THR MET ARG GLY ILE VAL LYS VAL ALA
SEQRES 22 F 547 ALA VAL LYS ALA PRO GLY PHE GLY ASP ARG ARG LYS ALA
SEQRES 23 F 547 MET LEU GLN ASP ILE ALA THR LEU THR GLY GLY THR VAL
SEQRES 24 F 547 ILE SER GLU GLU ILE GLY MET GLU LEU GLU LYS ALA THR
SEQRES 25 F 547 LEU GLU ASP LEU GLY GLN ALA LYS ARG VAL VAL ILE ASN
SEQRES 26 F 547 LYS ASP THR THR THR ILE ILE ASP GLY VAL GLY GLU GLU
SEQRES 27 F 547 ALA ALA ILE GLN GLY ARG VAL ALA GLN ILE ARG GLN GLN
SEQRES 28 F 547 ILE GLU GLU ALA THR SER ASP TYR ASP ARG GLU LYS LEU
SEQRES 29 F 547 GLN GLU ARG VAL ALA LYS LEU ALA GLY GLY VAL ALA VAL
SEQRES 30 F 547 ILE LYS VAL GLY ALA ALA THR GLU VAL GLU MET LYS GLU
SEQRES 31 F 547 LYS LYS ALA ARG VAL GLU ASP ALA LEU HIS ALA THR ARG
SEQRES 32 F 547 ALA ALA VAL GLU GLU GLY VAL VAL ALA GLY GLY GLY VAL
SEQRES 33 F 547 ALA LEU ILE ARG VAL ALA SER LYS LEU ALA ASP LEU ARG
SEQRES 34 F 547 GLY GLN ASN GLU ASP GLN ASN VAL GLY ILE LYS VAL ALA
SEQRES 35 F 547 LEU ARG ALA MET GLU ALA PRO LEU ARG GLN ILE VAL LEU
SEQRES 36 F 547 ASN CYS GLY GLU GLU PRO SER VAL VAL ALA ASN THR VAL
SEQRES 37 F 547 LYS GLY GLY ASP GLY ASN TYR GLY TYR ASN ALA ALA THR
SEQRES 38 F 547 GLU GLU TYR GLY ASN MET ILE ASP MET GLY ILE LEU ASP
SEQRES 39 F 547 PRO THR LYS VAL THR ARG SER ALA LEU GLN TYR ALA ALA
SEQRES 40 F 547 SER VAL ALA GLY LEU MET ILE THR THR GLU CYS MET VAL
SEQRES 41 F 547 THR ASP LEU PRO LYS ASN ASP ALA ALA ASP LEU GLY ALA
SEQRES 42 F 547 ALA GLY GLY MET GLY GLY MET GLY GLY MET GLY GLY MET
SEQRES 43 F 547 MET
SEQRES 1 G 547 ALA ALA LYS ASP VAL LYS PHE GLY ASN ASP ALA ARG VAL
SEQRES 2 G 547 LYS MET LEU ARG GLY VAL ASN VAL LEU ALA ASP ALA VAL
SEQRES 3 G 547 LYS VAL THR LEU GLY PRO LYS GLY ARG ASN VAL VAL LEU
SEQRES 4 G 547 ASP LYS SER PHE GLY ALA PRO THR ILE THR LYS ASP GLY
SEQRES 5 G 547 VAL SER VAL ALA ARG GLU ILE GLU LEU GLU ASP LYS PHE
SEQRES 6 G 547 GLU ASN MET GLY ALA GLN MET VAL LYS GLU VAL ALA SER
SEQRES 7 G 547 LYS ALA ASN ASP ALA ALA GLY ASP GLY THR THR THR ALA
SEQRES 8 G 547 THR VAL LEU ALA GLN ALA ILE ILE THR GLU GLY LEU LYS
SEQRES 9 G 547 ALA VAL ALA ALA GLY MET ASN PRO MET ASP LEU LYS ARG
SEQRES 10 G 547 GLY ILE ASP LYS ALA VAL THR ALA ALA VAL GLU GLU LEU
SEQRES 11 G 547 LYS ALA LEU SER VAL PRO CYS SER ASP SER LYS ALA ILE
SEQRES 12 G 547 ALA GLN VAL GLY THR ILE SER ALA ASN SER ASP GLU THR
SEQRES 13 G 547 VAL GLY LYS LEU ILE ALA GLU ALA MET ASP LYS VAL GLY
SEQRES 14 G 547 LYS GLU GLY VAL ILE THR VAL GLU ASP GLY THR GLY LEU
SEQRES 15 G 547 GLN ASP GLU LEU ASP VAL VAL GLU GLY MET GLN PHE ASP
SEQRES 16 G 547 ARG GLY TYR LEU SER PRO TYR PHE ILE ASN LYS PRO GLU
SEQRES 17 G 547 THR GLY ALA VAL GLU LEU GLU SER PRO PHE ILE LEU LEU
SEQRES 18 G 547 ALA ASP LYS LYS ILE SER ASN ILE ARG GLU MET LEU PRO
SEQRES 19 G 547 VAL LEU GLU ALA VAL ALA LYS ALA GLY LYS PRO LEU LEU
SEQRES 20 G 547 ILE ILE ALA GLU ASP VAL GLU GLY GLU ALA LEU ALA THR
SEQRES 21 G 547 LEU VAL VAL ASN THR MET ARG GLY ILE VAL LYS VAL ALA
SEQRES 22 G 547 ALA VAL LYS ALA PRO GLY PHE GLY ASP ARG ARG LYS ALA
SEQRES 23 G 547 MET LEU GLN ASP ILE ALA THR LEU THR GLY GLY THR VAL
SEQRES 24 G 547 ILE SER GLU GLU ILE GLY MET GLU LEU GLU LYS ALA THR
SEQRES 25 G 547 LEU GLU ASP LEU GLY GLN ALA LYS ARG VAL VAL ILE ASN
SEQRES 26 G 547 LYS ASP THR THR THR ILE ILE ASP GLY VAL GLY GLU GLU
SEQRES 27 G 547 ALA ALA ILE GLN GLY ARG VAL ALA GLN ILE ARG GLN GLN
SEQRES 28 G 547 ILE GLU GLU ALA THR SER ASP TYR ASP ARG GLU LYS LEU
SEQRES 29 G 547 GLN GLU ARG VAL ALA LYS LEU ALA GLY GLY VAL ALA VAL
SEQRES 30 G 547 ILE LYS VAL GLY ALA ALA THR GLU VAL GLU MET LYS GLU
SEQRES 31 G 547 LYS LYS ALA ARG VAL GLU ASP ALA LEU HIS ALA THR ARG
SEQRES 32 G 547 ALA ALA VAL GLU GLU GLY VAL VAL ALA GLY GLY GLY VAL
SEQRES 33 G 547 ALA LEU ILE ARG VAL ALA SER LYS LEU ALA ASP LEU ARG
SEQRES 34 G 547 GLY GLN ASN GLU ASP GLN ASN VAL GLY ILE LYS VAL ALA
SEQRES 35 G 547 LEU ARG ALA MET GLU ALA PRO LEU ARG GLN ILE VAL LEU
SEQRES 36 G 547 ASN CYS GLY GLU GLU PRO SER VAL VAL ALA ASN THR VAL
SEQRES 37 G 547 LYS GLY GLY ASP GLY ASN TYR GLY TYR ASN ALA ALA THR
SEQRES 38 G 547 GLU GLU TYR GLY ASN MET ILE ASP MET GLY ILE LEU ASP
SEQRES 39 G 547 PRO THR LYS VAL THR ARG SER ALA LEU GLN TYR ALA ALA
SEQRES 40 G 547 SER VAL ALA GLY LEU MET ILE THR THR GLU CYS MET VAL
SEQRES 41 G 547 THR ASP LEU PRO LYS ASN ASP ALA ALA ASP LEU GLY ALA
SEQRES 42 G 547 ALA GLY GLY MET GLY GLY MET GLY GLY MET GLY GLY MET
SEQRES 43 G 547 MET
SEQRES 1 H 547 ALA ALA LYS ASP VAL LYS PHE GLY ASN ASP ALA ARG VAL
SEQRES 2 H 547 LYS MET LEU ARG GLY VAL ASN VAL LEU ALA ASP ALA VAL
SEQRES 3 H 547 LYS VAL THR LEU GLY PRO LYS GLY ARG ASN VAL VAL LEU
SEQRES 4 H 547 ASP LYS SER PHE GLY ALA PRO THR ILE THR LYS ASP GLY
SEQRES 5 H 547 VAL SER VAL ALA ARG GLU ILE GLU LEU GLU ASP LYS PHE
SEQRES 6 H 547 GLU ASN MET GLY ALA GLN MET VAL LYS GLU VAL ALA SER
SEQRES 7 H 547 LYS ALA ASN ASP ALA ALA GLY ASP GLY THR THR THR ALA
SEQRES 8 H 547 THR VAL LEU ALA GLN ALA ILE ILE THR GLU GLY LEU LYS
SEQRES 9 H 547 ALA VAL ALA ALA GLY MET ASN PRO MET ASP LEU LYS ARG
SEQRES 10 H 547 GLY ILE ASP LYS ALA VAL THR ALA ALA VAL GLU GLU LEU
SEQRES 11 H 547 LYS ALA LEU SER VAL PRO CYS SER ASP SER LYS ALA ILE
SEQRES 12 H 547 ALA GLN VAL GLY THR ILE SER ALA ASN SER ASP GLU THR
SEQRES 13 H 547 VAL GLY LYS LEU ILE ALA GLU ALA MET ASP LYS VAL GLY
SEQRES 14 H 547 LYS GLU GLY VAL ILE THR VAL GLU ASP GLY THR GLY LEU
SEQRES 15 H 547 GLN ASP GLU LEU ASP VAL VAL GLU GLY MET GLN PHE ASP
SEQRES 16 H 547 ARG GLY TYR LEU SER PRO TYR PHE ILE ASN LYS PRO GLU
SEQRES 17 H 547 THR GLY ALA VAL GLU LEU GLU SER PRO PHE ILE LEU LEU
SEQRES 18 H 547 ALA ASP LYS LYS ILE SER ASN ILE ARG GLU MET LEU PRO
SEQRES 19 H 547 VAL LEU GLU ALA VAL ALA LYS ALA GLY LYS PRO LEU LEU
SEQRES 20 H 547 ILE ILE ALA GLU ASP VAL GLU GLY GLU ALA LEU ALA THR
SEQRES 21 H 547 LEU VAL VAL ASN THR MET ARG GLY ILE VAL LYS VAL ALA
SEQRES 22 H 547 ALA VAL LYS ALA PRO GLY PHE GLY ASP ARG ARG LYS ALA
SEQRES 23 H 547 MET LEU GLN ASP ILE ALA THR LEU THR GLY GLY THR VAL
SEQRES 24 H 547 ILE SER GLU GLU ILE GLY MET GLU LEU GLU LYS ALA THR
SEQRES 25 H 547 LEU GLU ASP LEU GLY GLN ALA LYS ARG VAL VAL ILE ASN
SEQRES 26 H 547 LYS ASP THR THR THR ILE ILE ASP GLY VAL GLY GLU GLU
SEQRES 27 H 547 ALA ALA ILE GLN GLY ARG VAL ALA GLN ILE ARG GLN GLN
SEQRES 28 H 547 ILE GLU GLU ALA THR SER ASP TYR ASP ARG GLU LYS LEU
SEQRES 29 H 547 GLN GLU ARG VAL ALA LYS LEU ALA GLY GLY VAL ALA VAL
SEQRES 30 H 547 ILE LYS VAL GLY ALA ALA THR GLU VAL GLU MET LYS GLU
SEQRES 31 H 547 LYS LYS ALA ARG VAL GLU ASP ALA LEU HIS ALA THR ARG
SEQRES 32 H 547 ALA ALA VAL GLU GLU GLY VAL VAL ALA GLY GLY GLY VAL
SEQRES 33 H 547 ALA LEU ILE ARG VAL ALA SER LYS LEU ALA ASP LEU ARG
SEQRES 34 H 547 GLY GLN ASN GLU ASP GLN ASN VAL GLY ILE LYS VAL ALA
SEQRES 35 H 547 LEU ARG ALA MET GLU ALA PRO LEU ARG GLN ILE VAL LEU
SEQRES 36 H 547 ASN CYS GLY GLU GLU PRO SER VAL VAL ALA ASN THR VAL
SEQRES 37 H 547 LYS GLY GLY ASP GLY ASN TYR GLY TYR ASN ALA ALA THR
SEQRES 38 H 547 GLU GLU TYR GLY ASN MET ILE ASP MET GLY ILE LEU ASP
SEQRES 39 H 547 PRO THR LYS VAL THR ARG SER ALA LEU GLN TYR ALA ALA
SEQRES 40 H 547 SER VAL ALA GLY LEU MET ILE THR THR GLU CYS MET VAL
SEQRES 41 H 547 THR ASP LEU PRO LYS ASN ASP ALA ALA ASP LEU GLY ALA
SEQRES 42 H 547 ALA GLY GLY MET GLY GLY MET GLY GLY MET GLY GLY MET
SEQRES 43 H 547 MET
SEQRES 1 I 547 ALA ALA LYS ASP VAL LYS PHE GLY ASN ASP ALA ARG VAL
SEQRES 2 I 547 LYS MET LEU ARG GLY VAL ASN VAL LEU ALA ASP ALA VAL
SEQRES 3 I 547 LYS VAL THR LEU GLY PRO LYS GLY ARG ASN VAL VAL LEU
SEQRES 4 I 547 ASP LYS SER PHE GLY ALA PRO THR ILE THR LYS ASP GLY
SEQRES 5 I 547 VAL SER VAL ALA ARG GLU ILE GLU LEU GLU ASP LYS PHE
SEQRES 6 I 547 GLU ASN MET GLY ALA GLN MET VAL LYS GLU VAL ALA SER
SEQRES 7 I 547 LYS ALA ASN ASP ALA ALA GLY ASP GLY THR THR THR ALA
SEQRES 8 I 547 THR VAL LEU ALA GLN ALA ILE ILE THR GLU GLY LEU LYS
SEQRES 9 I 547 ALA VAL ALA ALA GLY MET ASN PRO MET ASP LEU LYS ARG
SEQRES 10 I 547 GLY ILE ASP LYS ALA VAL THR ALA ALA VAL GLU GLU LEU
SEQRES 11 I 547 LYS ALA LEU SER VAL PRO CYS SER ASP SER LYS ALA ILE
SEQRES 12 I 547 ALA GLN VAL GLY THR ILE SER ALA ASN SER ASP GLU THR
SEQRES 13 I 547 VAL GLY LYS LEU ILE ALA GLU ALA MET ASP LYS VAL GLY
SEQRES 14 I 547 LYS GLU GLY VAL ILE THR VAL GLU ASP GLY THR GLY LEU
SEQRES 15 I 547 GLN ASP GLU LEU ASP VAL VAL GLU GLY MET GLN PHE ASP
SEQRES 16 I 547 ARG GLY TYR LEU SER PRO TYR PHE ILE ASN LYS PRO GLU
SEQRES 17 I 547 THR GLY ALA VAL GLU LEU GLU SER PRO PHE ILE LEU LEU
SEQRES 18 I 547 ALA ASP LYS LYS ILE SER ASN ILE ARG GLU MET LEU PRO
SEQRES 19 I 547 VAL LEU GLU ALA VAL ALA LYS ALA GLY LYS PRO LEU LEU
SEQRES 20 I 547 ILE ILE ALA GLU ASP VAL GLU GLY GLU ALA LEU ALA THR
SEQRES 21 I 547 LEU VAL VAL ASN THR MET ARG GLY ILE VAL LYS VAL ALA
SEQRES 22 I 547 ALA VAL LYS ALA PRO GLY PHE GLY ASP ARG ARG LYS ALA
SEQRES 23 I 547 MET LEU GLN ASP ILE ALA THR LEU THR GLY GLY THR VAL
SEQRES 24 I 547 ILE SER GLU GLU ILE GLY MET GLU LEU GLU LYS ALA THR
SEQRES 25 I 547 LEU GLU ASP LEU GLY GLN ALA LYS ARG VAL VAL ILE ASN
SEQRES 26 I 547 LYS ASP THR THR THR ILE ILE ASP GLY VAL GLY GLU GLU
SEQRES 27 I 547 ALA ALA ILE GLN GLY ARG VAL ALA GLN ILE ARG GLN GLN
SEQRES 28 I 547 ILE GLU GLU ALA THR SER ASP TYR ASP ARG GLU LYS LEU
SEQRES 29 I 547 GLN GLU ARG VAL ALA LYS LEU ALA GLY GLY VAL ALA VAL
SEQRES 30 I 547 ILE LYS VAL GLY ALA ALA THR GLU VAL GLU MET LYS GLU
SEQRES 31 I 547 LYS LYS ALA ARG VAL GLU ASP ALA LEU HIS ALA THR ARG
SEQRES 32 I 547 ALA ALA VAL GLU GLU GLY VAL VAL ALA GLY GLY GLY VAL
SEQRES 33 I 547 ALA LEU ILE ARG VAL ALA SER LYS LEU ALA ASP LEU ARG
SEQRES 34 I 547 GLY GLN ASN GLU ASP GLN ASN VAL GLY ILE LYS VAL ALA
SEQRES 35 I 547 LEU ARG ALA MET GLU ALA PRO LEU ARG GLN ILE VAL LEU
SEQRES 36 I 547 ASN CYS GLY GLU GLU PRO SER VAL VAL ALA ASN THR VAL
SEQRES 37 I 547 LYS GLY GLY ASP GLY ASN TYR GLY TYR ASN ALA ALA THR
SEQRES 38 I 547 GLU GLU TYR GLY ASN MET ILE ASP MET GLY ILE LEU ASP
SEQRES 39 I 547 PRO THR LYS VAL THR ARG SER ALA LEU GLN TYR ALA ALA
SEQRES 40 I 547 SER VAL ALA GLY LEU MET ILE THR THR GLU CYS MET VAL
SEQRES 41 I 547 THR ASP LEU PRO LYS ASN ASP ALA ALA ASP LEU GLY ALA
SEQRES 42 I 547 ALA GLY GLY MET GLY GLY MET GLY GLY MET GLY GLY MET
SEQRES 43 I 547 MET
SEQRES 1 J 547 ALA ALA LYS ASP VAL LYS PHE GLY ASN ASP ALA ARG VAL
SEQRES 2 J 547 LYS MET LEU ARG GLY VAL ASN VAL LEU ALA ASP ALA VAL
SEQRES 3 J 547 LYS VAL THR LEU GLY PRO LYS GLY ARG ASN VAL VAL LEU
SEQRES 4 J 547 ASP LYS SER PHE GLY ALA PRO THR ILE THR LYS ASP GLY
SEQRES 5 J 547 VAL SER VAL ALA ARG GLU ILE GLU LEU GLU ASP LYS PHE
SEQRES 6 J 547 GLU ASN MET GLY ALA GLN MET VAL LYS GLU VAL ALA SER
SEQRES 7 J 547 LYS ALA ASN ASP ALA ALA GLY ASP GLY THR THR THR ALA
SEQRES 8 J 547 THR VAL LEU ALA GLN ALA ILE ILE THR GLU GLY LEU LYS
SEQRES 9 J 547 ALA VAL ALA ALA GLY MET ASN PRO MET ASP LEU LYS ARG
SEQRES 10 J 547 GLY ILE ASP LYS ALA VAL THR ALA ALA VAL GLU GLU LEU
SEQRES 11 J 547 LYS ALA LEU SER VAL PRO CYS SER ASP SER LYS ALA ILE
SEQRES 12 J 547 ALA GLN VAL GLY THR ILE SER ALA ASN SER ASP GLU THR
SEQRES 13 J 547 VAL GLY LYS LEU ILE ALA GLU ALA MET ASP LYS VAL GLY
SEQRES 14 J 547 LYS GLU GLY VAL ILE THR VAL GLU ASP GLY THR GLY LEU
SEQRES 15 J 547 GLN ASP GLU LEU ASP VAL VAL GLU GLY MET GLN PHE ASP
SEQRES 16 J 547 ARG GLY TYR LEU SER PRO TYR PHE ILE ASN LYS PRO GLU
SEQRES 17 J 547 THR GLY ALA VAL GLU LEU GLU SER PRO PHE ILE LEU LEU
SEQRES 18 J 547 ALA ASP LYS LYS ILE SER ASN ILE ARG GLU MET LEU PRO
SEQRES 19 J 547 VAL LEU GLU ALA VAL ALA LYS ALA GLY LYS PRO LEU LEU
SEQRES 20 J 547 ILE ILE ALA GLU ASP VAL GLU GLY GLU ALA LEU ALA THR
SEQRES 21 J 547 LEU VAL VAL ASN THR MET ARG GLY ILE VAL LYS VAL ALA
SEQRES 22 J 547 ALA VAL LYS ALA PRO GLY PHE GLY ASP ARG ARG LYS ALA
SEQRES 23 J 547 MET LEU GLN ASP ILE ALA THR LEU THR GLY GLY THR VAL
SEQRES 24 J 547 ILE SER GLU GLU ILE GLY MET GLU LEU GLU LYS ALA THR
SEQRES 25 J 547 LEU GLU ASP LEU GLY GLN ALA LYS ARG VAL VAL ILE ASN
SEQRES 26 J 547 LYS ASP THR THR THR ILE ILE ASP GLY VAL GLY GLU GLU
SEQRES 27 J 547 ALA ALA ILE GLN GLY ARG VAL ALA GLN ILE ARG GLN GLN
SEQRES 28 J 547 ILE GLU GLU ALA THR SER ASP TYR ASP ARG GLU LYS LEU
SEQRES 29 J 547 GLN GLU ARG VAL ALA LYS LEU ALA GLY GLY VAL ALA VAL
SEQRES 30 J 547 ILE LYS VAL GLY ALA ALA THR GLU VAL GLU MET LYS GLU
SEQRES 31 J 547 LYS LYS ALA ARG VAL GLU ASP ALA LEU HIS ALA THR ARG
SEQRES 32 J 547 ALA ALA VAL GLU GLU GLY VAL VAL ALA GLY GLY GLY VAL
SEQRES 33 J 547 ALA LEU ILE ARG VAL ALA SER LYS LEU ALA ASP LEU ARG
SEQRES 34 J 547 GLY GLN ASN GLU ASP GLN ASN VAL GLY ILE LYS VAL ALA
SEQRES 35 J 547 LEU ARG ALA MET GLU ALA PRO LEU ARG GLN ILE VAL LEU
SEQRES 36 J 547 ASN CYS GLY GLU GLU PRO SER VAL VAL ALA ASN THR VAL
SEQRES 37 J 547 LYS GLY GLY ASP GLY ASN TYR GLY TYR ASN ALA ALA THR
SEQRES 38 J 547 GLU GLU TYR GLY ASN MET ILE ASP MET GLY ILE LEU ASP
SEQRES 39 J 547 PRO THR LYS VAL THR ARG SER ALA LEU GLN TYR ALA ALA
SEQRES 40 J 547 SER VAL ALA GLY LEU MET ILE THR THR GLU CYS MET VAL
SEQRES 41 J 547 THR ASP LEU PRO LYS ASN ASP ALA ALA ASP LEU GLY ALA
SEQRES 42 J 547 ALA GLY GLY MET GLY GLY MET GLY GLY MET GLY GLY MET
SEQRES 43 J 547 MET
SEQRES 1 K 547 ALA ALA LYS ASP VAL LYS PHE GLY ASN ASP ALA ARG VAL
SEQRES 2 K 547 LYS MET LEU ARG GLY VAL ASN VAL LEU ALA ASP ALA VAL
SEQRES 3 K 547 LYS VAL THR LEU GLY PRO LYS GLY ARG ASN VAL VAL LEU
SEQRES 4 K 547 ASP LYS SER PHE GLY ALA PRO THR ILE THR LYS ASP GLY
SEQRES 5 K 547 VAL SER VAL ALA ARG GLU ILE GLU LEU GLU ASP LYS PHE
SEQRES 6 K 547 GLU ASN MET GLY ALA GLN MET VAL LYS GLU VAL ALA SER
SEQRES 7 K 547 LYS ALA ASN ASP ALA ALA GLY ASP GLY THR THR THR ALA
SEQRES 8 K 547 THR VAL LEU ALA GLN ALA ILE ILE THR GLU GLY LEU LYS
SEQRES 9 K 547 ALA VAL ALA ALA GLY MET ASN PRO MET ASP LEU LYS ARG
SEQRES 10 K 547 GLY ILE ASP LYS ALA VAL THR ALA ALA VAL GLU GLU LEU
SEQRES 11 K 547 LYS ALA LEU SER VAL PRO CYS SER ASP SER LYS ALA ILE
SEQRES 12 K 547 ALA GLN VAL GLY THR ILE SER ALA ASN SER ASP GLU THR
SEQRES 13 K 547 VAL GLY LYS LEU ILE ALA GLU ALA MET ASP LYS VAL GLY
SEQRES 14 K 547 LYS GLU GLY VAL ILE THR VAL GLU ASP GLY THR GLY LEU
SEQRES 15 K 547 GLN ASP GLU LEU ASP VAL VAL GLU GLY MET GLN PHE ASP
SEQRES 16 K 547 ARG GLY TYR LEU SER PRO TYR PHE ILE ASN LYS PRO GLU
SEQRES 17 K 547 THR GLY ALA VAL GLU LEU GLU SER PRO PHE ILE LEU LEU
SEQRES 18 K 547 ALA ASP LYS LYS ILE SER ASN ILE ARG GLU MET LEU PRO
SEQRES 19 K 547 VAL LEU GLU ALA VAL ALA LYS ALA GLY LYS PRO LEU LEU
SEQRES 20 K 547 ILE ILE ALA GLU ASP VAL GLU GLY GLU ALA LEU ALA THR
SEQRES 21 K 547 LEU VAL VAL ASN THR MET ARG GLY ILE VAL LYS VAL ALA
SEQRES 22 K 547 ALA VAL LYS ALA PRO GLY PHE GLY ASP ARG ARG LYS ALA
SEQRES 23 K 547 MET LEU GLN ASP ILE ALA THR LEU THR GLY GLY THR VAL
SEQRES 24 K 547 ILE SER GLU GLU ILE GLY MET GLU LEU GLU LYS ALA THR
SEQRES 25 K 547 LEU GLU ASP LEU GLY GLN ALA LYS ARG VAL VAL ILE ASN
SEQRES 26 K 547 LYS ASP THR THR THR ILE ILE ASP GLY VAL GLY GLU GLU
SEQRES 27 K 547 ALA ALA ILE GLN GLY ARG VAL ALA GLN ILE ARG GLN GLN
SEQRES 28 K 547 ILE GLU GLU ALA THR SER ASP TYR ASP ARG GLU LYS LEU
SEQRES 29 K 547 GLN GLU ARG VAL ALA LYS LEU ALA GLY GLY VAL ALA VAL
SEQRES 30 K 547 ILE LYS VAL GLY ALA ALA THR GLU VAL GLU MET LYS GLU
SEQRES 31 K 547 LYS LYS ALA ARG VAL GLU ASP ALA LEU HIS ALA THR ARG
SEQRES 32 K 547 ALA ALA VAL GLU GLU GLY VAL VAL ALA GLY GLY GLY VAL
SEQRES 33 K 547 ALA LEU ILE ARG VAL ALA SER LYS LEU ALA ASP LEU ARG
SEQRES 34 K 547 GLY GLN ASN GLU ASP GLN ASN VAL GLY ILE LYS VAL ALA
SEQRES 35 K 547 LEU ARG ALA MET GLU ALA PRO LEU ARG GLN ILE VAL LEU
SEQRES 36 K 547 ASN CYS GLY GLU GLU PRO SER VAL VAL ALA ASN THR VAL
SEQRES 37 K 547 LYS GLY GLY ASP GLY ASN TYR GLY TYR ASN ALA ALA THR
SEQRES 38 K 547 GLU GLU TYR GLY ASN MET ILE ASP MET GLY ILE LEU ASP
SEQRES 39 K 547 PRO THR LYS VAL THR ARG SER ALA LEU GLN TYR ALA ALA
SEQRES 40 K 547 SER VAL ALA GLY LEU MET ILE THR THR GLU CYS MET VAL
SEQRES 41 K 547 THR ASP LEU PRO LYS ASN ASP ALA ALA ASP LEU GLY ALA
SEQRES 42 K 547 ALA GLY GLY MET GLY GLY MET GLY GLY MET GLY GLY MET
SEQRES 43 K 547 MET
SEQRES 1 L 547 ALA ALA LYS ASP VAL LYS PHE GLY ASN ASP ALA ARG VAL
SEQRES 2 L 547 LYS MET LEU ARG GLY VAL ASN VAL LEU ALA ASP ALA VAL
SEQRES 3 L 547 LYS VAL THR LEU GLY PRO LYS GLY ARG ASN VAL VAL LEU
SEQRES 4 L 547 ASP LYS SER PHE GLY ALA PRO THR ILE THR LYS ASP GLY
SEQRES 5 L 547 VAL SER VAL ALA ARG GLU ILE GLU LEU GLU ASP LYS PHE
SEQRES 6 L 547 GLU ASN MET GLY ALA GLN MET VAL LYS GLU VAL ALA SER
SEQRES 7 L 547 LYS ALA ASN ASP ALA ALA GLY ASP GLY THR THR THR ALA
SEQRES 8 L 547 THR VAL LEU ALA GLN ALA ILE ILE THR GLU GLY LEU LYS
SEQRES 9 L 547 ALA VAL ALA ALA GLY MET ASN PRO MET ASP LEU LYS ARG
SEQRES 10 L 547 GLY ILE ASP LYS ALA VAL THR ALA ALA VAL GLU GLU LEU
SEQRES 11 L 547 LYS ALA LEU SER VAL PRO CYS SER ASP SER LYS ALA ILE
SEQRES 12 L 547 ALA GLN VAL GLY THR ILE SER ALA ASN SER ASP GLU THR
SEQRES 13 L 547 VAL GLY LYS LEU ILE ALA GLU ALA MET ASP LYS VAL GLY
SEQRES 14 L 547 LYS GLU GLY VAL ILE THR VAL GLU ASP GLY THR GLY LEU
SEQRES 15 L 547 GLN ASP GLU LEU ASP VAL VAL GLU GLY MET GLN PHE ASP
SEQRES 16 L 547 ARG GLY TYR LEU SER PRO TYR PHE ILE ASN LYS PRO GLU
SEQRES 17 L 547 THR GLY ALA VAL GLU LEU GLU SER PRO PHE ILE LEU LEU
SEQRES 18 L 547 ALA ASP LYS LYS ILE SER ASN ILE ARG GLU MET LEU PRO
SEQRES 19 L 547 VAL LEU GLU ALA VAL ALA LYS ALA GLY LYS PRO LEU LEU
SEQRES 20 L 547 ILE ILE ALA GLU ASP VAL GLU GLY GLU ALA LEU ALA THR
SEQRES 21 L 547 LEU VAL VAL ASN THR MET ARG GLY ILE VAL LYS VAL ALA
SEQRES 22 L 547 ALA VAL LYS ALA PRO GLY PHE GLY ASP ARG ARG LYS ALA
SEQRES 23 L 547 MET LEU GLN ASP ILE ALA THR LEU THR GLY GLY THR VAL
SEQRES 24 L 547 ILE SER GLU GLU ILE GLY MET GLU LEU GLU LYS ALA THR
SEQRES 25 L 547 LEU GLU ASP LEU GLY GLN ALA LYS ARG VAL VAL ILE ASN
SEQRES 26 L 547 LYS ASP THR THR THR ILE ILE ASP GLY VAL GLY GLU GLU
SEQRES 27 L 547 ALA ALA ILE GLN GLY ARG VAL ALA GLN ILE ARG GLN GLN
SEQRES 28 L 547 ILE GLU GLU ALA THR SER ASP TYR ASP ARG GLU LYS LEU
SEQRES 29 L 547 GLN GLU ARG VAL ALA LYS LEU ALA GLY GLY VAL ALA VAL
SEQRES 30 L 547 ILE LYS VAL GLY ALA ALA THR GLU VAL GLU MET LYS GLU
SEQRES 31 L 547 LYS LYS ALA ARG VAL GLU ASP ALA LEU HIS ALA THR ARG
SEQRES 32 L 547 ALA ALA VAL GLU GLU GLY VAL VAL ALA GLY GLY GLY VAL
SEQRES 33 L 547 ALA LEU ILE ARG VAL ALA SER LYS LEU ALA ASP LEU ARG
SEQRES 34 L 547 GLY GLN ASN GLU ASP GLN ASN VAL GLY ILE LYS VAL ALA
SEQRES 35 L 547 LEU ARG ALA MET GLU ALA PRO LEU ARG GLN ILE VAL LEU
SEQRES 36 L 547 ASN CYS GLY GLU GLU PRO SER VAL VAL ALA ASN THR VAL
SEQRES 37 L 547 LYS GLY GLY ASP GLY ASN TYR GLY TYR ASN ALA ALA THR
SEQRES 38 L 547 GLU GLU TYR GLY ASN MET ILE ASP MET GLY ILE LEU ASP
SEQRES 39 L 547 PRO THR LYS VAL THR ARG SER ALA LEU GLN TYR ALA ALA
SEQRES 40 L 547 SER VAL ALA GLY LEU MET ILE THR THR GLU CYS MET VAL
SEQRES 41 L 547 THR ASP LEU PRO LYS ASN ASP ALA ALA ASP LEU GLY ALA
SEQRES 42 L 547 ALA GLY GLY MET GLY GLY MET GLY GLY MET GLY GLY MET
SEQRES 43 L 547 MET
SEQRES 1 M 547 ALA ALA LYS ASP VAL LYS PHE GLY ASN ASP ALA ARG VAL
SEQRES 2 M 547 LYS MET LEU ARG GLY VAL ASN VAL LEU ALA ASP ALA VAL
SEQRES 3 M 547 LYS VAL THR LEU GLY PRO LYS GLY ARG ASN VAL VAL LEU
SEQRES 4 M 547 ASP LYS SER PHE GLY ALA PRO THR ILE THR LYS ASP GLY
SEQRES 5 M 547 VAL SER VAL ALA ARG GLU ILE GLU LEU GLU ASP LYS PHE
SEQRES 6 M 547 GLU ASN MET GLY ALA GLN MET VAL LYS GLU VAL ALA SER
SEQRES 7 M 547 LYS ALA ASN ASP ALA ALA GLY ASP GLY THR THR THR ALA
SEQRES 8 M 547 THR VAL LEU ALA GLN ALA ILE ILE THR GLU GLY LEU LYS
SEQRES 9 M 547 ALA VAL ALA ALA GLY MET ASN PRO MET ASP LEU LYS ARG
SEQRES 10 M 547 GLY ILE ASP LYS ALA VAL THR ALA ALA VAL GLU GLU LEU
SEQRES 11 M 547 LYS ALA LEU SER VAL PRO CYS SER ASP SER LYS ALA ILE
SEQRES 12 M 547 ALA GLN VAL GLY THR ILE SER ALA ASN SER ASP GLU THR
SEQRES 13 M 547 VAL GLY LYS LEU ILE ALA GLU ALA MET ASP LYS VAL GLY
SEQRES 14 M 547 LYS GLU GLY VAL ILE THR VAL GLU ASP GLY THR GLY LEU
SEQRES 15 M 547 GLN ASP GLU LEU ASP VAL VAL GLU GLY MET GLN PHE ASP
SEQRES 16 M 547 ARG GLY TYR LEU SER PRO TYR PHE ILE ASN LYS PRO GLU
SEQRES 17 M 547 THR GLY ALA VAL GLU LEU GLU SER PRO PHE ILE LEU LEU
SEQRES 18 M 547 ALA ASP LYS LYS ILE SER ASN ILE ARG GLU MET LEU PRO
SEQRES 19 M 547 VAL LEU GLU ALA VAL ALA LYS ALA GLY LYS PRO LEU LEU
SEQRES 20 M 547 ILE ILE ALA GLU ASP VAL GLU GLY GLU ALA LEU ALA THR
SEQRES 21 M 547 LEU VAL VAL ASN THR MET ARG GLY ILE VAL LYS VAL ALA
SEQRES 22 M 547 ALA VAL LYS ALA PRO GLY PHE GLY ASP ARG ARG LYS ALA
SEQRES 23 M 547 MET LEU GLN ASP ILE ALA THR LEU THR GLY GLY THR VAL
SEQRES 24 M 547 ILE SER GLU GLU ILE GLY MET GLU LEU GLU LYS ALA THR
SEQRES 25 M 547 LEU GLU ASP LEU GLY GLN ALA LYS ARG VAL VAL ILE ASN
SEQRES 26 M 547 LYS ASP THR THR THR ILE ILE ASP GLY VAL GLY GLU GLU
SEQRES 27 M 547 ALA ALA ILE GLN GLY ARG VAL ALA GLN ILE ARG GLN GLN
SEQRES 28 M 547 ILE GLU GLU ALA THR SER ASP TYR ASP ARG GLU LYS LEU
SEQRES 29 M 547 GLN GLU ARG VAL ALA LYS LEU ALA GLY GLY VAL ALA VAL
SEQRES 30 M 547 ILE LYS VAL GLY ALA ALA THR GLU VAL GLU MET LYS GLU
SEQRES 31 M 547 LYS LYS ALA ARG VAL GLU ASP ALA LEU HIS ALA THR ARG
SEQRES 32 M 547 ALA ALA VAL GLU GLU GLY VAL VAL ALA GLY GLY GLY VAL
SEQRES 33 M 547 ALA LEU ILE ARG VAL ALA SER LYS LEU ALA ASP LEU ARG
SEQRES 34 M 547 GLY GLN ASN GLU ASP GLN ASN VAL GLY ILE LYS VAL ALA
SEQRES 35 M 547 LEU ARG ALA MET GLU ALA PRO LEU ARG GLN ILE VAL LEU
SEQRES 36 M 547 ASN CYS GLY GLU GLU PRO SER VAL VAL ALA ASN THR VAL
SEQRES 37 M 547 LYS GLY GLY ASP GLY ASN TYR GLY TYR ASN ALA ALA THR
SEQRES 38 M 547 GLU GLU TYR GLY ASN MET ILE ASP MET GLY ILE LEU ASP
SEQRES 39 M 547 PRO THR LYS VAL THR ARG SER ALA LEU GLN TYR ALA ALA
SEQRES 40 M 547 SER VAL ALA GLY LEU MET ILE THR THR GLU CYS MET VAL
SEQRES 41 M 547 THR ASP LEU PRO LYS ASN ASP ALA ALA ASP LEU GLY ALA
SEQRES 42 M 547 ALA GLY GLY MET GLY GLY MET GLY GLY MET GLY GLY MET
SEQRES 43 M 547 MET
SEQRES 1 N 547 ALA ALA LYS ASP VAL LYS PHE GLY ASN ASP ALA ARG VAL
SEQRES 2 N 547 LYS MET LEU ARG GLY VAL ASN VAL LEU ALA ASP ALA VAL
SEQRES 3 N 547 LYS VAL THR LEU GLY PRO LYS GLY ARG ASN VAL VAL LEU
SEQRES 4 N 547 ASP LYS SER PHE GLY ALA PRO THR ILE THR LYS ASP GLY
SEQRES 5 N 547 VAL SER VAL ALA ARG GLU ILE GLU LEU GLU ASP LYS PHE
SEQRES 6 N 547 GLU ASN MET GLY ALA GLN MET VAL LYS GLU VAL ALA SER
SEQRES 7 N 547 LYS ALA ASN ASP ALA ALA GLY ASP GLY THR THR THR ALA
SEQRES 8 N 547 THR VAL LEU ALA GLN ALA ILE ILE THR GLU GLY LEU LYS
SEQRES 9 N 547 ALA VAL ALA ALA GLY MET ASN PRO MET ASP LEU LYS ARG
SEQRES 10 N 547 GLY ILE ASP LYS ALA VAL THR ALA ALA VAL GLU GLU LEU
SEQRES 11 N 547 LYS ALA LEU SER VAL PRO CYS SER ASP SER LYS ALA ILE
SEQRES 12 N 547 ALA GLN VAL GLY THR ILE SER ALA ASN SER ASP GLU THR
SEQRES 13 N 547 VAL GLY LYS LEU ILE ALA GLU ALA MET ASP LYS VAL GLY
SEQRES 14 N 547 LYS GLU GLY VAL ILE THR VAL GLU ASP GLY THR GLY LEU
SEQRES 15 N 547 GLN ASP GLU LEU ASP VAL VAL GLU GLY MET GLN PHE ASP
SEQRES 16 N 547 ARG GLY TYR LEU SER PRO TYR PHE ILE ASN LYS PRO GLU
SEQRES 17 N 547 THR GLY ALA VAL GLU LEU GLU SER PRO PHE ILE LEU LEU
SEQRES 18 N 547 ALA ASP LYS LYS ILE SER ASN ILE ARG GLU MET LEU PRO
SEQRES 19 N 547 VAL LEU GLU ALA VAL ALA LYS ALA GLY LYS PRO LEU LEU
SEQRES 20 N 547 ILE ILE ALA GLU ASP VAL GLU GLY GLU ALA LEU ALA THR
SEQRES 21 N 547 LEU VAL VAL ASN THR MET ARG GLY ILE VAL LYS VAL ALA
SEQRES 22 N 547 ALA VAL LYS ALA PRO GLY PHE GLY ASP ARG ARG LYS ALA
SEQRES 23 N 547 MET LEU GLN ASP ILE ALA THR LEU THR GLY GLY THR VAL
SEQRES 24 N 547 ILE SER GLU GLU ILE GLY MET GLU LEU GLU LYS ALA THR
SEQRES 25 N 547 LEU GLU ASP LEU GLY GLN ALA LYS ARG VAL VAL ILE ASN
SEQRES 26 N 547 LYS ASP THR THR THR ILE ILE ASP GLY VAL GLY GLU GLU
SEQRES 27 N 547 ALA ALA ILE GLN GLY ARG VAL ALA GLN ILE ARG GLN GLN
SEQRES 28 N 547 ILE GLU GLU ALA THR SER ASP TYR ASP ARG GLU LYS LEU
SEQRES 29 N 547 GLN GLU ARG VAL ALA LYS LEU ALA GLY GLY VAL ALA VAL
SEQRES 30 N 547 ILE LYS VAL GLY ALA ALA THR GLU VAL GLU MET LYS GLU
SEQRES 31 N 547 LYS LYS ALA ARG VAL GLU ASP ALA LEU HIS ALA THR ARG
SEQRES 32 N 547 ALA ALA VAL GLU GLU GLY VAL VAL ALA GLY GLY GLY VAL
SEQRES 33 N 547 ALA LEU ILE ARG VAL ALA SER LYS LEU ALA ASP LEU ARG
SEQRES 34 N 547 GLY GLN ASN GLU ASP GLN ASN VAL GLY ILE LYS VAL ALA
SEQRES 35 N 547 LEU ARG ALA MET GLU ALA PRO LEU ARG GLN ILE VAL LEU
SEQRES 36 N 547 ASN CYS GLY GLU GLU PRO SER VAL VAL ALA ASN THR VAL
SEQRES 37 N 547 LYS GLY GLY ASP GLY ASN TYR GLY TYR ASN ALA ALA THR
SEQRES 38 N 547 GLU GLU TYR GLY ASN MET ILE ASP MET GLY ILE LEU ASP
SEQRES 39 N 547 PRO THR LYS VAL THR ARG SER ALA LEU GLN TYR ALA ALA
SEQRES 40 N 547 SER VAL ALA GLY LEU MET ILE THR THR GLU CYS MET VAL
SEQRES 41 N 547 THR ASP LEU PRO LYS ASN ASP ALA ALA ASP LEU GLY ALA
SEQRES 42 N 547 ALA GLY GLY MET GLY GLY MET GLY GLY MET GLY GLY MET
SEQRES 43 N 547 MET
HELIX 1 1 GLY A 9 LYS A 28 1 20
HELIX 2 2 VAL A 29 LEU A 31 5 3
HELIX 3 3 ASP A 52 ILE A 60 1 9
HELIX 4 4 ASP A 64 GLY A 86 1 23
HELIX 5 5 GLY A 88 ALA A 109 1 22
HELIX 6 6 ASN A 112 SER A 135 1 24
HELIX 7 7 ASP A 140 ALA A 152 1 13
HELIX 8 8 ASP A 155 GLY A 170 1 16
HELIX 9 9 SER A 201 ILE A 205 5 5
HELIX 10 10 LYS A 207 GLY A 211 5 5
HELIX 11 11 ILE A 230 GLU A 232 5 3
HELIX 12 12 MET A 233 GLY A 244 1 12
HELIX 13 13 GLU A 255 ARG A 268 1 14
HELIX 14 14 PHE A 281 GLY A 297 1 17
HELIX 15 15 GLU A 304 GLY A 306 5 3
HELIX 16 16 GLU A 308 ALA A 312 5 5
HELIX 17 17 THR A 313 LEU A 317 5 5
HELIX 18 18 GLU A 338 GLU A 354 1 17
HELIX 19 19 SER A 358 ALA A 373 1 16
HELIX 20 20 THR A 385 GLY A 410 1 26
HELIX 21 21 GLY A 416 SER A 424 1 9
HELIX 22 22 LYS A 425 ALA A 427 5 3
HELIX 23 23 ASN A 433 MET A 447 1 15
HELIX 24 24 GLU A 448 CYS A 458 1 11
HELIX 25 25 GLU A 461 GLY A 472 1 12
HELIX 26 26 THR A 497 THR A 516 1 20
HELIX 27 27 GLY B 9 LYS B 28 1 20
HELIX 28 28 VAL B 29 LEU B 31 5 3
HELIX 29 29 ASP B 52 ILE B 60 1 9
HELIX 30 30 ASP B 64 GLY B 86 1 23
HELIX 31 31 GLY B 88 ALA B 109 1 22
HELIX 32 32 ASN B 112 SER B 135 1 24
HELIX 33 33 ASP B 140 ALA B 152 1 13
HELIX 34 34 ASP B 155 GLY B 170 1 16
HELIX 35 35 SER B 201 ILE B 205 5 5
HELIX 36 36 ASN B 229 GLU B 232 5 4
HELIX 37 37 MET B 233 GLU B 238 1 6
HELIX 38 38 GLU B 238 GLY B 244 1 7
HELIX 39 39 ALA B 258 ARG B 268 1 11
HELIX 40 40 PHE B 281 GLY B 297 1 17
HELIX 41 41 GLU B 338 GLU B 354 1 17
HELIX 42 42 SER B 358 GLY B 375 1 18
HELIX 43 43 THR B 385 GLY B 410 1 26
HELIX 44 44 GLY B 416 LEU B 426 1 11
HELIX 45 45 ASN B 433 MET B 447 1 15
HELIX 46 46 GLU B 448 GLY B 459 1 12
HELIX 47 47 GLU B 461 GLY B 471 1 11
HELIX 48 48 THR B 497 THR B 516 1 20
HELIX 49 49 GLY C 9 LYS C 28 1 20
HELIX 50 50 VAL C 29 LEU C 31 5 3
HELIX 51 51 ASP C 52 ILE C 60 1 9
HELIX 52 52 ASP C 64 GLY C 86 1 23
HELIX 53 53 GLY C 88 ALA C 109 1 22
HELIX 54 54 ASN C 112 SER C 135 1 24
HELIX 55 55 ASP C 140 ALA C 152 1 13
HELIX 56 56 ASP C 155 GLY C 170 1 16
HELIX 57 57 MET C 233 LYS C 242 1 10
HELIX 58 58 GLY C 256 ARG C 268 1 13
HELIX 59 59 PHE C 281 GLY C 297 1 17
HELIX 60 60 GLU C 338 GLU C 354 1 17
HELIX 61 61 SER C 358 GLY C 375 1 18
HELIX 62 62 THR C 385 GLY C 410 1 26
HELIX 63 63 GLY C 416 LYS C 425 1 10
HELIX 64 64 ASN C 433 MET C 447 1 15
HELIX 65 65 GLU C 448 CYS C 458 1 11
HELIX 66 66 GLU C 461 GLY C 472 1 12
HELIX 67 67 THR C 497 THR C 516 1 20
HELIX 68 68 GLY D 9 LYS D 28 1 20
HELIX 69 69 VAL D 29 LEU D 31 5 3
HELIX 70 70 ASP D 52 ILE D 60 1 9
HELIX 71 71 ASP D 64 GLY D 86 1 23
HELIX 72 72 GLY D 88 ALA D 109 1 22
HELIX 73 73 ASN D 112 SER D 135 1 24
HELIX 74 74 ASP D 140 ALA D 152 1 13
HELIX 75 75 ASP D 155 GLY D 170 1 16
HELIX 76 76 ASN D 229 GLU D 232 5 4
HELIX 77 77 MET D 233 GLY D 244 1 12
HELIX 78 78 GLU D 255 MET D 267 1 13
HELIX 79 79 PHE D 281 GLY D 297 1 17
HELIX 80 80 THR D 313 LEU D 317 5 5
HELIX 81 81 GLU D 338 ALA D 356 1 19
HELIX 82 82 SER D 358 GLY D 375 1 18
HELIX 83 83 THR D 385 GLY D 410 1 26
HELIX 84 84 GLY D 416 LEU D 426 1 11
HELIX 85 85 ASN D 433 MET D 447 1 15
HELIX 86 86 GLU D 448 CYS D 458 1 11
HELIX 87 87 GLU D 461 GLY D 471 1 11
HELIX 88 88 THR D 497 THR D 516 1 20
HELIX 89 89 GLY E 9 LYS E 28 1 20
HELIX 90 90 VAL E 29 LEU E 31 5 3
HELIX 91 91 ASP E 52 ILE E 60 1 9
HELIX 92 92 ASP E 64 GLY E 86 1 23
HELIX 93 93 GLY E 88 ALA E 109 1 22
HELIX 94 94 ASN E 112 SER E 135 1 24
HELIX 95 95 ASP E 140 ALA E 152 1 13
HELIX 96 96 ASP E 155 GLY E 170 1 16
HELIX 97 97 SER E 201 ILE E 205 5 5
HELIX 98 98 ASN E 229 GLU E 232 5 4
HELIX 99 99 MET E 233 GLY E 244 1 12
HELIX 100 100 GLU E 255 ARG E 268 1 14
HELIX 101 101 PHE E 281 GLY E 297 1 17
HELIX 102 102 GLU E 338 GLU E 355 1 18
HELIX 103 103 SER E 358 ALA E 373 1 16
HELIX 104 104 THR E 385 GLY E 410 1 26
HELIX 105 105 GLY E 416 LYS E 425 1 10
HELIX 106 106 ASN E 433 MET E 447 1 15
HELIX 107 107 GLU E 448 CYS E 458 1 11
HELIX 108 108 GLU E 461 GLY E 472 1 12
HELIX 109 109 THR E 497 THR E 516 1 20
HELIX 110 110 GLY F 9 LYS F 28 1 20
HELIX 111 111 VAL F 29 LEU F 31 5 3
HELIX 112 112 ASP F 52 ILE F 60 1 9
HELIX 113 113 ASP F 64 GLY F 86 1 23
HELIX 114 114 GLY F 88 ALA F 109 1 22
HELIX 115 115 ASN F 112 SER F 135 1 24
HELIX 116 116 ASP F 140 ALA F 152 1 13
HELIX 117 117 ASP F 155 GLY F 170 1 16
HELIX 118 118 ASN F 229 GLU F 232 5 4
HELIX 119 119 MET F 233 GLY F 244 1 12
HELIX 120 120 GLU F 255 ARG F 268 1 14
HELIX 121 121 PHE F 281 GLY F 297 1 17
HELIX 122 122 GLU F 308 ALA F 312 5 5
HELIX 123 123 THR F 313 LEU F 317 5 5
HELIX 124 124 GLU F 338 GLU F 354 1 17
HELIX 125 125 SER F 358 GLY F 375 1 18
HELIX 126 126 THR F 385 GLY F 410 1 26
HELIX 127 127 GLY F 416 LYS F 425 1 10
HELIX 128 128 ASN F 433 MET F 447 1 15
HELIX 129 129 GLU F 448 GLY F 459 1 12
HELIX 130 130 GLU F 461 GLY F 472 1 12
HELIX 131 131 THR F 497 THR F 516 1 20
HELIX 132 132 GLY G 9 LYS G 28 1 20
HELIX 133 133 VAL G 29 LEU G 31 5 3
HELIX 134 134 ASP G 52 ILE G 60 1 9
HELIX 135 135 ASP G 64 GLY G 86 1 23
HELIX 136 136 GLY G 88 ALA G 109 1 22
HELIX 137 137 ASN G 112 SER G 135 1 24
HELIX 138 138 ASP G 140 ALA G 152 1 13
HELIX 139 139 ASP G 155 GLY G 170 1 16
HELIX 140 140 ASN G 229 GLU G 232 5 4
HELIX 141 141 MET G 233 GLY G 244 1 12
HELIX 142 142 GLU G 255 ARG G 268 1 14
HELIX 143 143 PHE G 281 GLY G 297 1 17
HELIX 144 144 GLU G 308 ALA G 312 5 5
HELIX 145 145 THR G 313 LEU G 317 5 5
HELIX 146 146 GLU G 338 ALA G 356 1 19
HELIX 147 147 SER G 358 GLY G 375 1 18
HELIX 148 148 THR G 385 GLY G 410 1 26
HELIX 149 149 GLY G 416 LYS G 425 1 10
HELIX 150 150 ASN G 433 MET G 447 1 15
HELIX 151 151 GLU G 448 CYS G 458 1 11
HELIX 152 152 GLU G 461 GLY G 471 1 11
HELIX 153 153 THR G 497 THR G 516 1 20
HELIX 154 154 GLY H 9 LYS H 28 1 20
HELIX 155 155 VAL H 29 LEU H 31 5 3
HELIX 156 156 ASP H 52 ILE H 60 1 9
HELIX 157 157 ASP H 64 GLY H 86 1 23
HELIX 158 158 GLY H 88 ALA H 109 1 22
HELIX 159 159 ASN H 112 SER H 135 1 24
HELIX 160 160 ASP H 140 SER H 151 1 12
HELIX 161 161 ASP H 155 GLY H 170 1 16
HELIX 162 162 SER H 201 ILE H 205 5 5
HELIX 163 163 ASN H 229 GLU H 232 5 4
HELIX 164 164 MET H 233 GLY H 244 1 12
HELIX 165 165 GLY H 256 ARG H 268 1 13
HELIX 166 166 GLY H 282 GLY H 297 1 16
HELIX 167 167 GLU H 308 ALA H 312 5 5
HELIX 168 168 THR H 313 LEU H 317 5 5
HELIX 169 169 ALA H 340 ALA H 356 1 17
HELIX 170 170 SER H 358 GLY H 375 1 18
HELIX 171 171 THR H 385 GLY H 410 1 26
HELIX 172 172 GLY H 416 LYS H 425 1 10
HELIX 173 173 ASN H 433 MET H 447 1 15
HELIX 174 174 GLU H 448 CYS H 458 1 11
HELIX 175 175 GLU H 461 GLY H 471 1 11
HELIX 176 176 ILE H 489 GLY H 492 5 4
HELIX 177 177 THR H 497 THR H 516 1 20
HELIX 178 178 GLY I 9 LYS I 28 1 20
HELIX 179 179 VAL I 29 LEU I 31 5 3
HELIX 180 180 ASP I 52 ILE I 60 1 9
HELIX 181 181 ASP I 64 GLY I 86 1 23
HELIX 182 182 GLY I 88 ALA I 109 1 22
HELIX 183 183 ASN I 112 SER I 135 1 24
HELIX 184 184 ASP I 140 SER I 151 1 12
HELIX 185 185 ASP I 155 GLY I 170 1 16
HELIX 186 186 ASN I 229 GLU I 232 5 4
HELIX 187 187 MET I 233 GLY I 244 1 12
HELIX 188 188 GLU I 255 GLY I 269 1 15
HELIX 189 189 GLY I 282 GLY I 297 1 16
HELIX 190 190 THR I 313 LEU I 317 5 5
HELIX 191 191 ALA I 340 GLU I 355 1 16
HELIX 192 192 SER I 358 GLY I 375 1 18
HELIX 193 193 THR I 385 GLY I 410 1 26
HELIX 194 194 GLY I 416 LYS I 425 1 10
HELIX 195 195 ASN I 433 MET I 447 1 15
HELIX 196 196 GLU I 448 CYS I 458 1 11
HELIX 197 197 GLU I 461 GLY I 471 1 11
HELIX 198 198 THR I 497 THR I 516 1 20
HELIX 199 199 GLY J 9 LYS J 28 1 20
HELIX 200 200 VAL J 29 LEU J 31 5 3
HELIX 201 201 ASP J 52 ILE J 60 1 9
HELIX 202 202 ASP J 64 GLY J 86 1 23
HELIX 203 203 GLY J 88 ALA J 109 1 22
HELIX 204 204 ASN J 112 SER J 135 1 24
HELIX 205 205 ASP J 140 SER J 151 1 12
HELIX 206 206 ASP J 155 GLY J 170 1 16
HELIX 207 207 SER J 201 ILE J 205 5 5
HELIX 208 208 ASN J 229 GLU J 232 5 4
HELIX 209 209 MET J 233 GLY J 244 1 12
HELIX 210 210 GLU J 255 GLY J 269 1 15
HELIX 211 211 GLY J 282 GLY J 297 1 16
HELIX 212 212 GLU J 308 ALA J 312 5 5
HELIX 213 213 THR J 313 LEU J 317 5 5
HELIX 214 214 ALA J 340 ALA J 356 1 17
HELIX 215 215 SER J 358 GLY J 375 1 18
HELIX 216 216 THR J 385 GLY J 410 1 26
HELIX 217 217 GLY J 416 LEU J 426 1 11
HELIX 218 218 ASN J 433 MET J 447 1 15
HELIX 219 219 GLU J 448 CYS J 458 1 11
HELIX 220 220 GLU J 461 GLY J 472 1 12
HELIX 221 221 THR J 497 THR J 516 1 20
HELIX 222 222 GLY K 9 LYS K 28 1 20
HELIX 223 223 VAL K 29 LEU K 31 5 3
HELIX 224 224 ASP K 52 ILE K 60 1 9
HELIX 225 225 ASP K 64 GLY K 86 1 23
HELIX 226 226 GLY K 88 ALA K 109 1 22
HELIX 227 227 ASN K 112 SER K 135 1 24
HELIX 228 228 ASP K 140 SER K 151 1 12
HELIX 229 229 ASP K 155 GLY K 170 1 16
HELIX 230 230 MET K 233 GLY K 244 1 12
HELIX 231 231 GLY K 256 GLY K 269 1 14
HELIX 232 232 GLY K 282 GLY K 297 1 16
HELIX 233 233 THR K 313 LEU K 317 5 5
HELIX 234 234 ALA K 340 GLU K 354 1 15
HELIX 235 235 SER K 358 ALA K 373 1 16
HELIX 236 236 THR K 385 GLY K 410 1 26
HELIX 237 237 GLY K 416 LYS K 425 1 10
HELIX 238 238 ASN K 433 MET K 447 1 15
HELIX 239 239 GLU K 448 CYS K 458 1 11
HELIX 240 240 GLU K 461 GLY K 471 1 11
HELIX 241 241 THR K 497 THR K 516 1 20
HELIX 242 242 GLY L 9 LYS L 28 1 20
HELIX 243 243 VAL L 29 LEU L 31 5 3
HELIX 244 244 ASP L 52 ILE L 60 1 9
HELIX 245 245 ASP L 64 GLY L 86 1 23
HELIX 246 246 GLY L 88 ALA L 109 1 22
HELIX 247 247 ASN L 112 SER L 135 1 24
HELIX 248 248 ASP L 140 SER L 151 1 12
HELIX 249 249 ASP L 155 GLY L 170 1 16
HELIX 250 250 SER L 201 ILE L 205 5 5
HELIX 251 251 ASN L 229 GLU L 232 5 4
HELIX 252 252 MET L 233 GLY L 244 1 12
HELIX 253 253 GLU L 255 GLY L 269 1 15
HELIX 254 254 GLY L 282 GLY L 297 1 16
HELIX 255 255 GLU L 308 ALA L 312 5 5
HELIX 256 256 GLU L 338 ALA L 356 1 19
HELIX 257 257 SER L 358 ALA L 373 1 16
HELIX 258 258 THR L 385 GLY L 410 1 26
HELIX 259 259 GLY L 416 LYS L 425 1 10
HELIX 260 260 ASN L 433 MET L 447 1 15
HELIX 261 261 GLU L 448 CYS L 458 1 11
HELIX 262 262 GLU L 461 GLY L 471 1 11
HELIX 263 263 THR L 497 THR L 516 1 20
HELIX 264 264 GLY M 9 LYS M 28 1 20
HELIX 265 265 VAL M 29 LEU M 31 5 3
HELIX 266 266 ASP M 52 ILE M 60 1 9
HELIX 267 267 ASP M 64 GLY M 86 1 23
HELIX 268 268 GLY M 88 ALA M 109 1 22
HELIX 269 269 ASN M 112 SER M 135 1 24
HELIX 270 270 ASP M 140 SER M 151 1 12
HELIX 271 271 ASP M 155 GLY M 170 1 16
HELIX 272 272 SER M 201 ILE M 205 5 5
HELIX 273 273 LYS M 207 GLY M 211 5 5
HELIX 274 274 ASN M 229 GLY M 244 1 16
HELIX 275 275 GLU M 255 GLY M 269 1 15
HELIX 276 276 PHE M 281 GLY M 297 1 17
HELIX 277 277 THR M 313 LEU M 317 5 5
HELIX 278 278 GLU M 338 GLU M 355 1 18
HELIX 279 279 SER M 358 GLY M 375 1 18
HELIX 280 280 THR M 385 GLY M 410 1 26
HELIX 281 281 GLY M 416 LYS M 425 1 10
HELIX 282 282 ASN M 433 MET M 447 1 15
HELIX 283 283 GLU M 448 CYS M 458 1 11
HELIX 284 284 GLU M 461 GLY M 471 1 11
HELIX 285 285 THR M 497 THR M 516 1 20
HELIX 286 286 GLY N 9 LYS N 28 1 20
HELIX 287 287 VAL N 29 LEU N 31 5 3
HELIX 288 288 ASP N 52 ILE N 60 1 9
HELIX 289 289 ASP N 64 GLY N 86 1 23
HELIX 290 290 GLY N 88 ALA N 109 1 22
HELIX 291 291 ASN N 112 SER N 135 1 24
HELIX 292 292 ASP N 140 SER N 151 1 12
HELIX 293 293 ASP N 155 GLY N 170 1 16
HELIX 294 294 SER N 201 ILE N 205 5 5
HELIX 295 295 ASN N 229 GLU N 232 5 4
HELIX 296 296 MET N 233 GLY N 244 1 12
HELIX 297 297 GLU N 255 ARG N 268 1 14
HELIX 298 298 PHE N 281 GLY N 297 1 17
HELIX 299 299 GLU N 308 ALA N 312 5 5
HELIX 300 300 THR N 313 LEU N 317 5 5
HELIX 301 301 ALA N 340 GLU N 355 1 16
HELIX 302 302 SER N 358 ALA N 373 1 16
HELIX 303 303 THR N 385 GLY N 410 1 26
HELIX 304 304 GLY N 416 LEU N 426 1 11
HELIX 305 305 ASN N 433 MET N 447 1 15
HELIX 306 306 GLU N 448 CYS N 458 1 11
HELIX 307 307 GLU N 461 GLY N 472 1 12
HELIX 308 308 THR N 497 THR N 516 1 20
SHEET 1 A 4 LYS A 4 PHE A 8 0
SHEET 2 A 4 THR A 517 ASP A 523 -1 O THR A 522 N ASP A 5
SHEET 3 A 4 ASN G 37 LEU G 40 1 O VAL G 39 N VAL A 521
SHEET 4 A 4 THR G 48 THR G 50 -1 O THR G 48 N LEU G 40
SHEET 1 B 4 THR A 48 THR A 50 0
SHEET 2 B 4 ASN A 37 LEU A 40 -1 N LEU A 40 O THR A 48
SHEET 3 B 4 THR B 517 ASP B 523 1 O VAL B 521 N VAL A 39
SHEET 4 B 4 LYS B 4 PHE B 8 -1 N ASP B 5 O THR B 522
SHEET 1 C 3 VAL A 174 ASP A 179 0
SHEET 2 C 3 VAL A 376 VAL A 381 1 O ALA A 377 N THR A 176
SHEET 3 C 3 GLU A 186 VAL A 190 -1 N ASP A 188 O VAL A 378
SHEET 1 D 6 GLY A 192 PHE A 195 0
SHEET 2 D 6 THR A 330 GLY A 335 -1 O ILE A 332 N MET A 193
SHEET 3 D 6 GLY A 318 ILE A 325 -1 N VAL A 324 O THR A 331
SHEET 4 D 6 PHE A 219 ASP A 224 -1 N ILE A 220 O GLY A 318
SHEET 5 D 6 LEU A 247 ALA A 251 1 O ILE A 250 N LEU A 221
SHEET 6 D 6 VAL A 273 LYS A 277 1 O VAL A 276 N ILE A 249
SHEET 1 E 4 VAL A 213 GLU A 216 0
SHEET 2 E 4 GLY A 318 ILE A 325 -1 O ILE A 325 N VAL A 213
SHEET 3 E 4 PHE A 219 ASP A 224 -1 N ILE A 220 O GLY A 318
SHEET 4 E 4 VAL A 300 SER A 302 1 O ILE A 301 N ASP A 224
SHEET 1 F 2 LYS A 226 ILE A 227 0
SHEET 2 F 2 ASP A 253 VAL A 254 1 O ASP A 253 N ILE A 227
SHEET 1 G 2 VAL A 411 ALA A 413 0
SHEET 2 G 2 LEU A 494 PRO A 496 -1 O ASP A 495 N VAL A 412
SHEET 1 H 2 TYR A 476 TYR A 478 0
SHEET 2 H 2 TYR A 485 ASN A 487 -1 O GLY A 486 N GLY A 477
SHEET 1 I 4 THR B 48 THR B 50 0
SHEET 2 I 4 ASN B 37 LEU B 40 -1 N LEU B 40 O THR B 48
SHEET 3 I 4 THR C 517 ASP C 523 1 O VAL C 521 N VAL B 39
SHEET 4 I 4 LYS C 4 PHE C 8 -1 N ASP C 5 O THR C 522
SHEET 1 J 3 VAL B 174 ASP B 179 0
SHEET 2 J 3 VAL B 376 VAL B 381 1 O ALA B 377 N THR B 176
SHEET 3 J 3 GLU B 186 VAL B 190 -1 N VAL B 190 O VAL B 376
SHEET 1 K 6 GLY B 192 PHE B 195 0
SHEET 2 K 6 THR B 330 GLY B 335 -1 O THR B 330 N PHE B 195
SHEET 3 K 6 GLY B 318 ILE B 325 -1 N ARG B 322 O ILE B 333
SHEET 4 K 6 PHE B 219 ILE B 227 -1 N ILE B 220 O GLY B 318
SHEET 5 K 6 LEU B 247 VAL B 254 1 O ILE B 250 N LEU B 221
SHEET 6 K 6 VAL B 273 LYS B 277 1 O VAL B 276 N ILE B 249
SHEET 1 L 4 VAL B 213 GLU B 216 0
SHEET 2 L 4 GLY B 318 ILE B 325 -1 O VAL B 323 N LEU B 215
SHEET 3 L 4 PHE B 219 ILE B 227 -1 N ILE B 220 O GLY B 318
SHEET 4 L 4 ILE B 301 SER B 302 1 O ILE B 301 N ASP B 224
SHEET 1 M 2 VAL B 411 ALA B 413 0
SHEET 2 M 2 LEU B 494 PRO B 496 -1 O ASP B 495 N VAL B 412
SHEET 1 N 2 TYR B 476 ASN B 479 0
SHEET 2 N 2 GLU B 484 ASN B 487 -1 O GLY B 486 N GLY B 477
SHEET 1 O 4 THR C 48 THR C 50 0
SHEET 2 O 4 ASN C 37 LEU C 40 -1 N LEU C 40 O THR C 48
SHEET 3 O 4 THR D 517 ASP D 523 1 O CYS D 519 N VAL C 39
SHEET 4 O 4 LYS D 4 PHE D 8 -1 N ASP D 5 O THR D 522
SHEET 1 P 3 VAL C 174 ASP C 179 0
SHEET 2 P 3 VAL C 376 VAL C 381 1 O ALA C 377 N THR C 176
SHEET 3 P 3 GLU C 186 VAL C 190 -1 N GLU C 186 O LYS C 380
SHEET 1 Q 4 MET C 193 PHE C 195 0
SHEET 2 Q 4 THR C 330 GLY C 335 -1 O THR C 330 N PHE C 195
SHEET 3 Q 4 GLY C 318 ILE C 325 -1 N ARG C 322 O ILE C 333
SHEET 4 Q 4 VAL C 213 GLU C 216 -1 N VAL C 213 O ILE C 325
SHEET 1 R 6 MET C 193 PHE C 195 0
SHEET 2 R 6 THR C 330 GLY C 335 -1 O THR C 330 N PHE C 195
SHEET 3 R 6 GLY C 318 ILE C 325 -1 N ARG C 322 O ILE C 333
SHEET 4 R 6 PHE C 219 ILE C 227 -1 N ILE C 220 O GLY C 318
SHEET 5 R 6 LEU C 247 VAL C 254 1 O ILE C 250 N LEU C 221
SHEET 6 R 6 VAL C 273 LYS C 277 1 O VAL C 276 N ILE C 249
SHEET 1 S 2 VAL C 411 ALA C 413 0
SHEET 2 S 2 LEU C 494 PRO C 496 -1 O ASP C 495 N VAL C 412
SHEET 1 T 2 TYR C 476 ASN C 479 0
SHEET 2 T 2 GLU C 484 ASN C 487 -1 O GLY C 486 N GLY C 477
SHEET 1 U 4 THR D 48 THR D 50 0
SHEET 2 U 4 ASN D 37 LEU D 40 -1 N LEU D 40 O THR D 48
SHEET 3 U 4 THR E 517 ASP E 523 1 O VAL E 521 N VAL D 39
SHEET 4 U 4 LYS E 4 PHE E 8 -1 N ASP E 5 O THR E 522
SHEET 1 V 3 VAL D 174 ASP D 179 0
SHEET 2 V 3 VAL D 376 VAL D 381 1 O ALA D 377 N THR D 176
SHEET 3 V 3 GLU D 186 VAL D 190 -1 N GLU D 186 O LYS D 380
SHEET 1 W 6 GLY D 192 PHE D 195 0
SHEET 2 W 6 THR D 330 GLY D 335 -1 O ILE D 332 N MET D 193
SHEET 3 W 6 GLY D 318 ILE D 325 -1 N ARG D 322 O ILE D 333
SHEET 4 W 6 PHE D 219 ASP D 224 -1 N ILE D 220 O GLY D 318
SHEET 5 W 6 LEU D 247 ALA D 251 1 O LEU D 248 N PHE D 219
SHEET 6 W 6 VAL D 273 LYS D 277 1 O ALA D 274 N LEU D 247
SHEET 1 X 4 VAL D 213 GLU D 216 0
SHEET 2 X 4 GLY D 318 ILE D 325 -1 O ILE D 325 N VAL D 213
SHEET 3 X 4 PHE D 219 ASP D 224 -1 N ILE D 220 O GLY D 318
SHEET 4 X 4 ILE D 301 SER D 302 1 O ILE D 301 N LEU D 222
SHEET 1 Y 2 LYS D 226 ILE D 227 0
SHEET 2 Y 2 ASP D 253 VAL D 254 1 O ASP D 253 N ILE D 227
SHEET 1 Z 2 VAL D 411 ALA D 413 0
SHEET 2 Z 2 LEU D 494 PRO D 496 -1 O ASP D 495 N VAL D 412
SHEET 1 AA 2 TYR D 476 TYR D 478 0
SHEET 2 AA 2 TYR D 485 ASN D 487 -1 O GLY D 486 N GLY D 477
SHEET 1 AB 4 THR E 48 THR E 50 0
SHEET 2 AB 4 ASN E 37 LEU E 40 -1 N LEU E 40 O THR E 48
SHEET 3 AB 4 THR F 517 ASP F 523 1 O VAL F 521 N VAL E 39
SHEET 4 AB 4 LYS F 4 PHE F 8 -1 N ASP F 5 O THR F 522
SHEET 1 AC 3 ILE E 175 ASP E 179 0
SHEET 2 AC 3 VAL E 376 VAL E 381 1 O ALA E 377 N THR E 176
SHEET 3 AC 3 GLU E 186 VAL E 190 -1 N VAL E 190 O VAL E 376
SHEET 1 AD 6 MET E 193 PHE E 195 0
SHEET 2 AD 6 THR E 330 GLY E 335 -1 O ILE E 332 N MET E 193
SHEET 3 AD 6 GLY E 318 ILE E 325 -1 N ARG E 322 O ILE E 333
SHEET 4 AD 6 PHE E 219 ILE E 227 -1 N ILE E 220 O GLY E 318
SHEET 5 AD 6 LEU E 247 VAL E 254 1 O ILE E 250 N LEU E 221
SHEET 6 AD 6 VAL E 273 LYS E 277 1 O ALA E 274 N ILE E 249
SHEET 1 AE 4 VAL E 213 GLU E 216 0
SHEET 2 AE 4 GLY E 318 ILE E 325 -1 O ILE E 325 N VAL E 213
SHEET 3 AE 4 PHE E 219 ILE E 227 -1 N ILE E 220 O GLY E 318
SHEET 4 AE 4 ILE E 301 SER E 302 1 O ILE E 301 N LEU E 222
SHEET 1 AF 2 VAL E 411 ALA E 413 0
SHEET 2 AF 2 LEU E 494 PRO E 496 -1 O ASP E 495 N VAL E 412
SHEET 1 AG 2 TYR E 476 ASN E 479 0
SHEET 2 AG 2 GLU E 484 ASN E 487 -1 O GLU E 484 N ASN E 479
SHEET 1 AH 4 THR F 48 THR F 50 0
SHEET 2 AH 4 ASN F 37 LEU F 40 -1 N LEU F 40 O THR F 48
SHEET 3 AH 4 THR G 517 ASP G 523 1 O VAL G 521 N VAL F 39
SHEET 4 AH 4 LYS G 4 PHE G 8 -1 N ASP G 5 O THR G 522
SHEET 1 AI 3 VAL F 174 ASP F 179 0
SHEET 2 AI 3 VAL F 376 VAL F 381 1 O ALA F 377 N THR F 176
SHEET 3 AI 3 GLU F 186 VAL F 190 -1 N VAL F 190 O VAL F 376
SHEET 1 AJ 6 MET F 193 PHE F 195 0
SHEET 2 AJ 6 THR F 330 GLY F 335 -1 O ILE F 332 N MET F 193
SHEET 3 AJ 6 GLY F 318 ILE F 325 -1 N VAL F 324 O THR F 331
SHEET 4 AJ 6 PHE F 219 ILE F 227 -1 N ILE F 220 O GLY F 318
SHEET 5 AJ 6 LEU F 247 VAL F 254 1 O ILE F 250 N ALA F 223
SHEET 6 AJ 6 VAL F 273 LYS F 277 1 O VAL F 276 N ILE F 249
SHEET 1 AK 4 VAL F 213 GLU F 216 0
SHEET 2 AK 4 GLY F 318 ILE F 325 -1 O ILE F 325 N VAL F 213
SHEET 3 AK 4 PHE F 219 ILE F 227 -1 N ILE F 220 O GLY F 318
SHEET 4 AK 4 ILE F 301 SER F 302 1 O ILE F 301 N ASP F 224
SHEET 1 AL 2 VAL F 411 ALA F 413 0
SHEET 2 AL 2 LEU F 494 PRO F 496 -1 O ASP F 495 N VAL F 412
SHEET 1 AM 2 TYR F 476 TYR F 478 0
SHEET 2 AM 2 TYR F 485 ASN F 487 -1 O GLY F 486 N GLY F 477
SHEET 1 AN 3 VAL G 174 ASP G 179 0
SHEET 2 AN 3 VAL G 376 VAL G 381 1 O ALA G 377 N THR G 176
SHEET 3 AN 3 GLU G 186 VAL G 190 -1 N ASP G 188 O VAL G 378
SHEET 1 AO 6 GLY G 192 PHE G 195 0
SHEET 2 AO 6 THR G 330 GLY G 335 -1 O ILE G 332 N MET G 193
SHEET 3 AO 6 GLY G 318 ILE G 325 -1 N VAL G 324 O THR G 331
SHEET 4 AO 6 PHE G 219 ILE G 227 -1 N ILE G 220 O GLY G 318
SHEET 5 AO 6 LEU G 247 VAL G 254 1 O ILE G 250 N ALA G 223
SHEET 6 AO 6 VAL G 273 LYS G 277 1 O ALA G 274 N ILE G 249
SHEET 1 AP 4 VAL G 213 GLU G 216 0
SHEET 2 AP 4 GLY G 318 ILE G 325 -1 O VAL G 323 N LEU G 215
SHEET 3 AP 4 PHE G 219 ILE G 227 -1 N ILE G 220 O GLY G 318
SHEET 4 AP 4 ILE G 301 SER G 302 1 O ILE G 301 N ASP G 224
SHEET 1 AQ 2 VAL G 411 ALA G 413 0
SHEET 2 AQ 2 LEU G 494 PRO G 496 -1 O ASP G 495 N VAL G 412
SHEET 1 AR 2 TYR G 476 ASN G 479 0
SHEET 2 AR 2 GLU G 484 ASN G 487 -1 O GLU G 484 N ASN G 479
SHEET 1 AS 4 LYS H 4 PHE H 8 0
SHEET 2 AS 4 THR H 517 ASP H 523 -1 O THR H 522 N ASP H 5
SHEET 3 AS 4 ASN N 37 LEU N 40 1 O VAL N 39 N VAL H 521
SHEET 4 AS 4 THR N 48 THR N 50 -1 O THR N 48 N LEU N 40
SHEET 1 AT 4 THR H 48 THR H 50 0
SHEET 2 AT 4 ASN H 37 LEU H 40 -1 N LEU H 40 O THR H 48
SHEET 3 AT 4 THR I 517 ASP I 523 1 O VAL I 521 N VAL H 39
SHEET 4 AT 4 LYS I 4 PHE I 8 -1 N ASP I 5 O THR I 522
SHEET 1 AU 3 VAL H 174 ASP H 179 0
SHEET 2 AU 3 VAL H 376 VAL H 381 1 O ILE H 379 N GLU H 178
SHEET 3 AU 3 GLU H 186 VAL H 190 -1 N VAL H 190 O VAL H 376
SHEET 1 AV 6 MET H 193 PHE H 195 0
SHEET 2 AV 6 THR H 330 GLY H 335 -1 O THR H 330 N PHE H 195
SHEET 3 AV 6 GLY H 318 ILE H 325 -1 N ARG H 322 O ILE H 333
SHEET 4 AV 6 PHE H 219 ALA H 223 -1 N ILE H 220 O GLY H 318
SHEET 5 AV 6 LEU H 247 ALA H 251 1 O LEU H 248 N PHE H 219
SHEET 6 AV 6 VAL H 273 LYS H 277 1 O ALA H 274 N ILE H 249
SHEET 1 AW 4 VAL H 213 GLU H 216 0
SHEET 2 AW 4 GLY H 318 ILE H 325 -1 O ILE H 325 N VAL H 213
SHEET 3 AW 4 PHE H 219 ALA H 223 -1 N ILE H 220 O GLY H 318
SHEET 4 AW 4 VAL H 300 ILE H 301 1 O ILE H 301 N LEU H 222
SHEET 1 AX 2 LYS H 226 ILE H 227 0
SHEET 2 AX 2 ASP H 253 VAL H 254 1 O ASP H 253 N ILE H 227
SHEET 1 AY 2 VAL H 411 ALA H 413 0
SHEET 2 AY 2 LEU H 494 PRO H 496 -1 O ASP H 495 N VAL H 412
SHEET 1 AZ 2 TYR H 476 TYR H 478 0
SHEET 2 AZ 2 TYR H 485 ASN H 487 -1 O GLY H 486 N GLY H 477
SHEET 1 BA 4 THR I 48 THR I 50 0
SHEET 2 BA 4 ASN I 37 LEU I 40 -1 N LEU I 40 O THR I 48
SHEET 3 BA 4 THR J 517 ASP J 523 1 O VAL J 521 N VAL I 39
SHEET 4 BA 4 LYS J 4 PHE J 8 -1 N ASP J 5 O THR J 522
SHEET 1 BB 3 VAL I 174 ASP I 179 0
SHEET 2 BB 3 VAL I 376 VAL I 381 1 O ILE I 379 N GLU I 178
SHEET 3 BB 3 GLU I 186 VAL I 190 -1 N ASP I 188 O VAL I 378
SHEET 1 BC 6 GLY I 192 PHE I 195 0
SHEET 2 BC 6 THR I 330 GLY I 335 -1 O ILE I 332 N MET I 193
SHEET 3 BC 6 GLY I 318 ILE I 325 -1 N ARG I 322 O ILE I 333
SHEET 4 BC 6 PHE I 219 ALA I 223 -1 N ILE I 220 O GLY I 318
SHEET 5 BC 6 LEU I 247 ALA I 251 1 O LEU I 248 N LEU I 221
SHEET 6 BC 6 VAL I 273 LYS I 277 1 O ALA I 274 N LEU I 247
SHEET 1 BD 4 VAL I 213 GLU I 216 0
SHEET 2 BD 4 GLY I 318 ILE I 325 -1 O ILE I 325 N VAL I 213
SHEET 3 BD 4 PHE I 219 ALA I 223 -1 N ILE I 220 O GLY I 318
SHEET 4 BD 4 VAL I 300 ILE I 301 1 O ILE I 301 N LEU I 222
SHEET 1 BE 2 LYS I 226 ILE I 227 0
SHEET 2 BE 2 ASP I 253 VAL I 254 1 O ASP I 253 N ILE I 227
SHEET 1 BF 2 VAL I 411 ALA I 413 0
SHEET 2 BF 2 LEU I 494 PRO I 496 -1 O ASP I 495 N VAL I 412
SHEET 1 BG 4 THR J 48 THR J 50 0
SHEET 2 BG 4 ASN J 37 LEU J 40 -1 N LEU J 40 O THR J 48
SHEET 3 BG 4 THR K 517 ASP K 523 1 O VAL K 521 N VAL J 39
SHEET 4 BG 4 LYS K 4 PHE K 8 -1 N ASP K 5 O THR K 522
SHEET 1 BH 3 ILE J 175 ASP J 179 0
SHEET 2 BH 3 VAL J 376 VAL J 381 1 O ALA J 377 N THR J 176
SHEET 3 BH 3 GLU J 186 VAL J 190 -1 N ASP J 188 O VAL J 378
SHEET 1 BI 4 GLY J 192 PHE J 195 0
SHEET 2 BI 4 THR J 329 GLY J 335 -1 O ILE J 332 N MET J 193
SHEET 3 BI 4 GLY J 318 ASN J 326 -1 N VAL J 324 O THR J 331
SHEET 4 BI 4 VAL J 213 GLU J 216 -1 N VAL J 213 O ILE J 325
SHEET 1 BJ 6 GLY J 192 PHE J 195 0
SHEET 2 BJ 6 THR J 329 GLY J 335 -1 O ILE J 332 N MET J 193
SHEET 3 BJ 6 GLY J 318 ASN J 326 -1 N VAL J 324 O THR J 331
SHEET 4 BJ 6 PHE J 219 ILE J 227 -1 N ILE J 220 O GLY J 318
SHEET 5 BJ 6 LEU J 247 VAL J 254 1 O ILE J 250 N LEU J 221
SHEET 6 BJ 6 VAL J 273 LYS J 277 1 O ALA J 274 N LEU J 247
SHEET 1 BK 2 VAL J 411 ALA J 413 0
SHEET 2 BK 2 LEU J 494 PRO J 496 -1 O ASP J 495 N VAL J 412
SHEET 1 BL 2 TYR J 476 TYR J 478 0
SHEET 2 BL 2 TYR J 485 ASN J 487 -1 O GLY J 486 N GLY J 477
SHEET 1 BM 4 THR K 48 THR K 50 0
SHEET 2 BM 4 ASN K 37 LEU K 40 -1 N LEU K 40 O THR K 48
SHEET 3 BM 4 THR L 517 ASP L 523 1 O VAL L 521 N VAL K 39
SHEET 4 BM 4 LYS L 4 PHE L 8 -1 N ASP L 5 O THR L 522
SHEET 1 BN 3 VAL K 174 ASP K 179 0
SHEET 2 BN 3 VAL K 376 VAL K 381 1 O ILE K 379 N THR K 176
SHEET 3 BN 3 GLU K 186 VAL K 190 -1 N ASP K 188 O VAL K 378
SHEET 1 BO 6 GLY K 192 PHE K 195 0
SHEET 2 BO 6 THR K 330 GLY K 335 -1 O ILE K 332 N MET K 193
SHEET 3 BO 6 GLY K 318 ILE K 325 -1 N VAL K 324 O THR K 331
SHEET 4 BO 6 PHE K 219 ALA K 223 -1 N ILE K 220 O GLY K 318
SHEET 5 BO 6 LEU K 247 ALA K 251 1 O LEU K 248 N PHE K 219
SHEET 6 BO 6 VAL K 273 LYS K 277 1 O ALA K 274 N ILE K 249
SHEET 1 BP 4 VAL K 213 GLU K 216 0
SHEET 2 BP 4 GLY K 318 ILE K 325 -1 O VAL K 323 N LEU K 215
SHEET 3 BP 4 PHE K 219 ALA K 223 -1 N ILE K 220 O GLY K 318
SHEET 4 BP 4 VAL K 300 ILE K 301 1 O ILE K 301 N LEU K 222
SHEET 1 BQ 2 VAL K 411 ALA K 413 0
SHEET 2 BQ 2 LEU K 494 PRO K 496 -1 O ASP K 495 N VAL K 412
SHEET 1 BR 2 TYR K 476 ASN K 479 0
SHEET 2 BR 2 GLU K 484 ASN K 487 -1 O GLU K 484 N ASN K 479
SHEET 1 BS 4 THR L 48 THR L 50 0
SHEET 2 BS 4 ASN L 37 LEU L 40 -1 N LEU L 40 O THR L 48
SHEET 3 BS 4 THR M 517 ASP M 523 1 O CYS M 519 N VAL L 39
SHEET 4 BS 4 LYS M 4 PHE M 8 -1 N ASP M 5 O THR M 522
SHEET 1 BT 3 VAL L 174 ASP L 179 0
SHEET 2 BT 3 VAL L 376 VAL L 381 1 O ILE L 379 N THR L 176
SHEET 3 BT 3 GLU L 186 VAL L 190 -1 N VAL L 190 O VAL L 376
SHEET 1 BU 4 MET L 193 PHE L 195 0
SHEET 2 BU 4 THR L 330 GLY L 335 -1 O THR L 330 N PHE L 195
SHEET 3 BU 4 GLY L 318 ILE L 325 -1 N ARG L 322 O ILE L 333
SHEET 4 BU 4 VAL L 213 GLU L 216 -1 N VAL L 213 O ILE L 325
SHEET 1 BV 6 MET L 193 PHE L 195 0
SHEET 2 BV 6 THR L 330 GLY L 335 -1 O THR L 330 N PHE L 195
SHEET 3 BV 6 GLY L 318 ILE L 325 -1 N ARG L 322 O ILE L 333
SHEET 4 BV 6 PHE L 219 ALA L 223 -1 N ILE L 220 O GLY L 318
SHEET 5 BV 6 LEU L 247 ALA L 251 1 O ILE L 250 N ALA L 223
SHEET 6 BV 6 VAL L 273 LYS L 277 1 O ALA L 274 N ILE L 249
SHEET 1 BW 2 VAL L 411 ALA L 413 0
SHEET 2 BW 2 LEU L 494 PRO L 496 -1 O ASP L 495 N VAL L 412
SHEET 1 BX 4 THR M 48 THR M 50 0
SHEET 2 BX 4 ASN M 37 LEU M 40 -1 N LEU M 40 O THR M 48
SHEET 3 BX 4 THR N 517 ASP N 523 1 O VAL N 521 N VAL M 39
SHEET 4 BX 4 LYS N 4 PHE N 8 -1 N ASP N 5 O THR N 522
SHEET 1 BY 3 ILE M 175 ASP M 179 0
SHEET 2 BY 3 VAL M 376 VAL M 381 1 O ALA M 377 N THR M 176
SHEET 3 BY 3 GLU M 186 VAL M 190 -1 N ASP M 188 O VAL M 378
SHEET 1 BZ 4 GLY M 192 PHE M 195 0
SHEET 2 BZ 4 THR M 330 GLY M 335 -1 O ILE M 332 N MET M 193
SHEET 3 BZ 4 GLY M 318 ILE M 325 -1 N VAL M 324 O THR M 331
SHEET 4 BZ 4 VAL M 213 GLU M 216 -1 N LEU M 215 O VAL M 323
SHEET 1 CA 6 GLY M 192 PHE M 195 0
SHEET 2 CA 6 THR M 330 GLY M 335 -1 O ILE M 332 N MET M 193
SHEET 3 CA 6 GLY M 318 ILE M 325 -1 N VAL M 324 O THR M 331
SHEET 4 CA 6 PHE M 219 LEU M 222 -1 N ILE M 220 O GLY M 318
SHEET 5 CA 6 LEU M 247 ALA M 251 1 O ILE M 250 N LEU M 221
SHEET 6 CA 6 VAL M 273 LYS M 277 1 O ALA M 274 N ILE M 249
SHEET 1 CB 2 VAL M 411 ALA M 413 0
SHEET 2 CB 2 LEU M 494 PRO M 496 -1 O ASP M 495 N VAL M 412
SHEET 1 CC 2 TYR M 476 TYR M 478 0
SHEET 2 CC 2 TYR M 485 ASN M 487 -1 O GLY M 486 N GLY M 477
SHEET 1 CD 3 ILE N 175 ASP N 179 0
SHEET 2 CD 3 VAL N 376 VAL N 381 1 O ALA N 377 N THR N 176
SHEET 3 CD 3 GLU N 186 VAL N 190 -1 N ASP N 188 O VAL N 378
SHEET 1 CE 4 GLY N 192 PHE N 195 0
SHEET 2 CE 4 THR N 330 GLY N 335 -1 O ILE N 332 N MET N 193
SHEET 3 CE 4 GLY N 318 ILE N 325 -1 N VAL N 324 O THR N 331
SHEET 4 CE 4 VAL N 213 GLU N 216 -1 N VAL N 213 O ILE N 325
SHEET 1 CF 6 GLY N 192 PHE N 195 0
SHEET 2 CF 6 THR N 330 GLY N 335 -1 O ILE N 332 N MET N 193
SHEET 3 CF 6 GLY N 318 ILE N 325 -1 N VAL N 324 O THR N 331
SHEET 4 CF 6 PHE N 219 LEU N 222 -1 N ILE N 220 O GLY N 318
SHEET 5 CF 6 LEU N 247 ALA N 251 1 O LEU N 248 N LEU N 221
SHEET 6 CF 6 VAL N 273 LYS N 277 1 O VAL N 276 N ILE N 249
SHEET 1 CG 2 LYS N 226 ILE N 227 0
SHEET 2 CG 2 ASP N 253 VAL N 254 1 O ASP N 253 N ILE N 227
SHEET 1 CH 2 VAL N 411 ALA N 413 0
SHEET 2 CH 2 LEU N 494 PRO N 496 -1 O ASP N 495 N VAL N 412
CRYST1 136.423 262.254 147.074 90.00 99.83 90.00 P 1 21 1 28
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 0.007330 0.000000 0.001270 0.00000
SCALE2 0.000000 0.003813 0.000000 0.00000
SCALE3 0.000000 0.000000 0.006901 0.00000
(ATOM LINES ARE NOT SHOWN.)
END
