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Database: PDB
Entry: 2Y7J
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HEADER    TRANSFERASE                             31-JAN-11   2Y7J              
TITLE     STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2                      
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER 
COMPND   3 ISOFORM;                                                             
COMPND   4 CHAIN: A, B, C, D;                                                   
COMPND   5 FRAGMENT: RESIDUES 6-293;                                            
COMPND   6 SYNONYM: PHOSPHORYLASE KINASE GAMMA 2, PHK-GAMMA-T, PSK-C3,          
COMPND   7 PHOSPHORYLASE KINASE SUBUNIT GAMMA-2;                                
COMPND   8 EC: 2.7.11.19;                                                       
COMPND   9 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);                                 
SOURCE   8 EXPRESSION_SYSTEM_VARIANT: R-LA;                                     
SOURCE   9 EXPRESSION_SYSTEM_VECTOR: PNIC-ZB                                    
KEYWDS    TRANSFERASE                                                           
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    J.R.C.MUNIZ,A.SHRESTHA,P.SAVITSKY,J.WANG,P.RELLOS,O.FEDOROV,          
AUTHOR   2 N.BURGESS-BROWN,B.BRENNER,G.BERRIDGE,J.M.ELKINS,T.KROJER,M.VOLLMAR,  
AUTHOR   3 K.H.CHE,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,C.BOUNTRA,  
AUTHOR   4 S.KNAPP                                                              
REVDAT   3   24-JAN-18 2Y7J    1       JRNL                                     
REVDAT   2   12-OCT-11 2Y7J    1       SOURCE REMARK HETATM VERSN               
REVDAT   1   09-FEB-11 2Y7J    0                                                
JRNL        AUTH   J.R.C.MUNIZ,A.SHRESTHA,P.SAVITSKY,J.WANG,P.RELLOS,O.FEDOROV, 
JRNL        AUTH 2 N.BURGESS-BROWN,B.BRENNER,G.BERRIDGE,J.M.ELKINS,T.KROJER,    
JRNL        AUTH 3 M.VOLLMAR,K.H.CHE,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,    
JRNL        AUTH 4 J.WEIGELT,C.BOUNTRA,S.KNAPP                                  
JRNL        TITL   STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2             
JRNL        REF    TO BE PUBLISHED                                              
JRNL        REFN                                                                
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.50 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : BUSTER 2.8.0                                         
REMARK   3   AUTHORS     : BRICOGNE,BLANC,BRANDL,FLENSBURG,KELLER,              
REMARK   3               : PACIOREK,ROVERSI,SHARFF,SMART,VONRHEIN,              
REMARK   3               : WOMACK,MATTHEWS,TEN EYCK,TRONRUD                     
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.50                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 61.14                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : NULL                           
REMARK   3   NUMBER OF REFLECTIONS             : 46353                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD           : THROUGHOUT                     
REMARK   3   FREE R VALUE TEST SET SELECTION   : RANDOM                         
REMARK   3   R VALUE     (WORKING + TEST SET)  : 0.184                          
REMARK   3   R VALUE            (WORKING SET)  : 0.182                          
REMARK   3   FREE R VALUE                      : 0.216                          
REMARK   3   FREE R VALUE TEST SET SIZE   (%)  : 5.050                          
REMARK   3   FREE R VALUE TEST SET COUNT       : 2343                           
REMARK   3   ESTIMATED ERROR OF FREE R VALUE   : NULL                           
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED               : 20                       
REMARK   3   BIN RESOLUTION RANGE HIGH   (ANGSTROMS) : 2.50                     
REMARK   3   BIN RESOLUTION RANGE LOW    (ANGSTROMS) : 2.56                     
REMARK   3   BIN COMPLETENESS (WORKING+TEST)     (%) : NULL                     
REMARK   3   REFLECTIONS IN BIN (WORKING + TEST SET) : 3283                     
REMARK   3   BIN R VALUE        (WORKING + TEST SET) : 0.2166                   
REMARK   3   REFLECTIONS IN BIN        (WORKING SET) : 3100                     
REMARK   3   BIN R VALUE               (WORKING SET) : 0.2133                   
REMARK   3   BIN FREE R VALUE                        : 0.2722                   
REMARK   3   BIN FREE R VALUE TEST SET SIZE      (%) : 5.57                     
REMARK   3   BIN FREE R VALUE TEST SET COUNT         : 183                      
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE     : NULL                     
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 8940                                    
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 116                                     
REMARK   3   SOLVENT ATOMS            : 283                                     
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 56.58                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 51.11                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : -0.37820                                             
REMARK   3    B22 (A**2) : -2.91620                                             
REMARK   3    B33 (A**2) : 3.29430                                              
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 0.00000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED COORDINATE ERROR.                                         
REMARK   3   ESD FROM LUZZATI PLOT                    (A) : 0.306               
REMARK   3   DPI (BLOW EQ-10) BASED ON R VALUE        (A) : NULL                
REMARK   3   DPI (BLOW EQ-9) BASED ON FREE R VALUE    (A) : NULL                
REMARK   3   DPI (CRUICKSHANK) BASED ON R VALUE       (A) : NULL                
REMARK   3   DPI (CRUICKSHANK) BASED ON FREE R VALUE  (A) : NULL                
REMARK   3                                                                      
REMARK   3   REFERENCES: BLOW, D. (2002) ACTA CRYST D58, 792-797                
REMARK   3               CRUICKSHANK, D.W.J. (1999) ACTA CRYST D55, 583-601     
REMARK   3                                                                      
REMARK   3 CORRELATION COEFFICIENTS.                                            
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.939                         
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.919                         
REMARK   3                                                                      
REMARK   3   NUMBER OF GEOMETRIC FUNCTION TERMS DEFINED : 15                    
REMARK   3   TERM                          COUNT    WEIGHT   FUNCTION.          
REMARK   3    BOND LENGTHS              : 9318   ; 2.000  ; HARMONIC            
REMARK   3    BOND ANGLES               : 12635  ; 2.000  ; HARMONIC            
REMARK   3    TORSION ANGLES            : 4273   ; 2.000  ; SINUSOIDAL          
REMARK   3    TRIGONAL CARBON PLANES    : 248    ; 2.000  ; HARMONIC            
REMARK   3    GENERAL PLANES            : 1386   ; 5.000  ; HARMONIC            
REMARK   3    ISOTROPIC THERMAL FACTORS : 9318   ; 20.000 ; HARMONIC            
REMARK   3    BAD NON-BONDED CONTACTS   : 1      ; 5.000  ; SEMIHARMONIC        
REMARK   3    IMPROPER TORSIONS         : NULL   ; NULL   ; NULL                
REMARK   3    PSEUDOROTATION ANGLES     : NULL   ; NULL   ; NULL                
REMARK   3    CHIRAL IMPROPER TORSION   : 1188   ; 5.000  ; SEMIHARMONIC        
REMARK   3    SUM OF OCCUPANCIES        : NULL   ; NULL   ; NULL                
REMARK   3    UTILITY DISTANCES         : NULL   ; NULL   ; NULL                
REMARK   3    UTILITY ANGLES            : NULL   ; NULL   ; NULL                
REMARK   3    UTILITY TORSION           : NULL   ; NULL   ; NULL                
REMARK   3    IDEAL-DIST CONTACT TERM   : 10788  ; 4.000  ; SEMIHARMONIC        
REMARK   3                                                                      
REMARK   3   RMS DEVIATIONS FROM IDEAL VALUES.                                  
REMARK   3    BOND LENGTHS                       (A) : 0.010                    
REMARK   3    BOND ANGLES                  (DEGREES) : 1.08                     
REMARK   3    PEPTIDE OMEGA TORSION ANGLES (DEGREES) : 3.20                     
REMARK   3    OTHER TORSION ANGLES         (DEGREES) : 2.89                     
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 24                                         
REMARK   3                                                                      
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 10 - 118)                           
REMARK   3    ORIGIN FOR THE GROUP (A):  -24.5224   -3.1174   47.2739           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.0810 T22:    0.0140                                    
REMARK   3     T33:   -0.0961 T12:    0.0178                                    
REMARK   3     T13:    0.0010 T23:    0.0348                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    0.5490 L22:    2.3057                                    
REMARK   3     L33:    2.4548 L12:    0.1333                                    
REMARK   3     L13:    0.1551 L23:    0.8495                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.1063 S12:    0.0740 S13:    0.0532                     
REMARK   3     S21:    0.0745 S22:    0.0161 S23:    0.2650                     
REMARK   3     S31:   -0.2144 S32:   -0.0373 S33:    0.0902                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 119 - 131)                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -10.0438  -24.7278   33.1752           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.0303 T22:    0.1951                                    
REMARK   3     T33:   -0.0943 T12:    0.1520                                    
REMARK   3     T13:    0.0258 T23:   -0.0389                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.0918 L22:    0.6875                                    
REMARK   3     L33:    0.0000 L12:   -2.9002                                    
REMARK   3     L13:    2.0709 L23:    1.1794                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0137 S12:   -0.0505 S13:   -0.1750                     
REMARK   3     S21:    0.0190 S22:    0.1030 S23:   -0.1399                     
REMARK   3     S31:   -0.0245 S32:    0.2315 S33:   -0.1167                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 132 - 178)                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -25.2961  -19.9314   41.7306           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.0438 T22:   -0.0669                                    
REMARK   3     T33:   -0.1138 T12:    0.0116                                    
REMARK   3     T13:   -0.0414 T23:   -0.0248                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    0.6004 L22:    2.2751                                    
REMARK   3     L33:    2.9994 L12:   -0.6737                                    
REMARK   3     L13:    0.3588 L23:    0.1994                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0502 S12:   -0.0220 S13:    0.1798                     
REMARK   3     S21:    0.2210 S22:   -0.0470 S23:    0.1868                     
REMARK   3     S31:    0.4079 S32:    0.1184 S33:   -0.0033                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 179 - 186)                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -43.4873  -20.7281   36.8591           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.1272 T22:   -0.0112                                    
REMARK   3     T33:    0.2985 T12:   -0.1009                                    
REMARK   3     T13:   -0.1152 T23:    0.0070                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    3.0857 L22:    0.8666                                    
REMARK   3     L33:    0.0000 L12:    0.6114                                    
REMARK   3     L13:    0.3025 L23:   -0.1809                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0168 S12:    0.0382 S13:    0.0288                     
REMARK   3     S21:    0.1774 S22:   -0.1072 S23:    0.0401                     
REMARK   3     S31:    0.0701 S32:   -0.1287 S33:    0.0904                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 187 - 232)                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -31.2986  -22.4086   28.2363           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.0219 T22:   -0.0282                                    
REMARK   3     T33:   -0.0983 T12:   -0.0146                                    
REMARK   3     T13:   -0.0812 T23:   -0.0092                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    0.0000 L22:    4.3493                                    
REMARK   3     L33:    3.5009 L12:   -1.3302                                    
REMARK   3     L13:    0.0251 L23:    1.1135                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0656 S12:    0.1161 S13:   -0.0252                     
REMARK   3     S21:   -0.4808 S22:   -0.0907 S23:    0.5442                     
REMARK   3     S31:    0.4256 S32:   -0.0588 S33:    0.0250                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 233 - 292)                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -24.6404  -29.9401   26.2073           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.0585 T22:   -0.1380                                    
REMARK   3     T33:   -0.2295 T12:    0.0456                                    
REMARK   3     T13:   -0.0655 T23:   -0.1211                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    3.3249 L22:    2.9897                                    
REMARK   3     L33:    6.4938 L12:   -1.2141                                    
REMARK   3     L13:    1.0540 L23:   -0.9141                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.0227 S12:    0.4148 S13:   -0.3923                     
REMARK   3     S21:   -0.0840 S22:   -0.0377 S23:    0.0355                     
REMARK   3     S31:    0.5442 S32:    0.5083 S33:    0.0604                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: (CHAIN B AND RESID 11 - 55)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   -2.0360   -3.2267   -6.7566           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.0599 T22:   -0.1043                                    
REMARK   3     T33:   -0.0695 T12:   -0.0098                                    
REMARK   3     T13:    0.0108 T23:   -0.0440                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.3497 L22:    1.1648                                    
REMARK   3     L33:    2.5747 L12:   -0.4532                                    
REMARK   3     L13:    1.5748 L23:   -0.5183                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.1458 S12:   -0.0184 S13:    0.0357                     
REMARK   3     S21:    0.0796 S22:   -0.0549 S23:   -0.3538                     
REMARK   3     S31:   -0.1084 S32:    0.1848 S33:   -0.0909                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    SELECTION: (CHAIN B AND RESID 56 - 82)                            
REMARK   3    ORIGIN FOR THE GROUP (A):    3.1159   14.1691   -3.9376           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.1789 T22:    0.0391                                    
REMARK   3     T33:   -0.0088 T12:   -0.1520                                    
REMARK   3     T13:    0.0049 T23:   -0.1414                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    1.2060 L22:    1.9945                                    
REMARK   3     L33:    0.9978 L12:   -2.9104                                    
REMARK   3     L13:    2.7320 L23:   -2.9104                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.0248 S12:    0.0161 S13:    0.1956                     
REMARK   3     S21:   -0.2038 S22:   -0.0851 S23:    0.2739                     
REMARK   3     S31:   -0.2393 S32:    0.1440 S33:    0.1099                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    SELECTION: (CHAIN B AND RESID 83 - 110)                           
REMARK   3    ORIGIN FOR THE GROUP (A):    7.2251    0.9966   -2.8629           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.0032 T22:   -0.0230                                    
REMARK   3     T33:   -0.0245 T12:   -0.0337                                    
REMARK   3     T13:    0.0051 T23:   -0.0576                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.2240 L22:    0.0000                                    
REMARK   3     L33:    2.8570 L12:    2.9104                                    
REMARK   3     L13:    2.1676 L23:    2.8478                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.0128 S12:   -0.1330 S13:    0.1808                     
REMARK   3     S21:   -0.2134 S22:    0.1116 S23:   -0.0957                     
REMARK   3     S31:   -0.0628 S32:    0.2266 S33:   -0.0988                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 111 - 183)                          
REMARK   3    ORIGIN FOR THE GROUP (A):   11.7813    1.1243   12.7587           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.0736 T22:   -0.0344                                    
REMARK   3     T33:   -0.0413 T12:   -0.0425                                    
REMARK   3     T13:   -0.0281 T23:   -0.0037                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    0.9018 L22:    4.3122                                    
REMARK   3     L33:    2.2577 L12:    0.3679                                    
REMARK   3     L13:    1.1381 L23:    1.7724                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.0064 S12:    0.2091 S13:   -0.3028                     
REMARK   3     S21:   -0.4253 S22:    0.4113 S23:   -0.3430                     
REMARK   3     S31:    0.4388 S32:    0.1757 S33:   -0.4050                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 184 - 229)                          
REMARK   3    ORIGIN FOR THE GROUP (A):   11.6413   15.3745   18.5428           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.0447 T22:    0.0163                                    
REMARK   3     T33:   -0.1135 T12:   -0.0662                                    
REMARK   3     T13:   -0.0214 T23:    0.0291                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    0.1286 L22:    7.0637                                    
REMARK   3     L33:    0.0000 L12:    1.4167                                    
REMARK   3     L13:   -0.1977 L23:    2.2715                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0943 S12:    0.0756 S13:    0.0545                     
REMARK   3     S21:    0.3661 S22:    0.1660 S23:    0.0143                     
REMARK   3     S31:   -0.1648 S32:    0.0612 S33:   -0.2603                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 230 - 293)                          
REMARK   3    ORIGIN FOR THE GROUP (A):   14.5938    6.4037   27.6853           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.0285 T22:   -0.1337                                    
REMARK   3     T33:   -0.2131 T12:   -0.1084                                    
REMARK   3     T13:   -0.1520 T23:   -0.0155                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    3.2538 L22:    7.2407                                    
REMARK   3     L33:    8.2135 L12:    1.8735                                    
REMARK   3     L13:   -0.3743 L23:   -0.4479                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0112 S12:   -0.5065 S13:   -0.4714                     
REMARK   3     S21:    0.5442 S22:    0.0935 S23:   -0.3617                     
REMARK   3     S31:   -0.1597 S32:    0.3735 S33:   -0.1047                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 10 - 111)                           
REMARK   3    ORIGIN FOR THE GROUP (A):  -20.2557   -1.0067  -10.6763           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.0069 T22:   -0.0608                                    
REMARK   3     T33:   -0.0833 T12:    0.0144                                    
REMARK   3     T13:   -0.0745 T23:   -0.0351                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    1.9222 L22:    0.5961                                    
REMARK   3     L33:    2.3247 L12:    0.0511                                    
REMARK   3     L13:   -0.3002 L23:   -0.3424                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0592 S12:    0.0601 S13:   -0.0353                     
REMARK   3     S21:    0.0666 S22:   -0.0516 S23:   -0.0689                     
REMARK   3     S31:    0.0735 S32:   -0.0664 S33:   -0.0076                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 112 - 178)                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -38.2396    3.1254   -1.4931           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.0507 T22:   -0.0043                                    
REMARK   3     T33:   -0.1076 T12:    0.0782                                    
REMARK   3     T13:   -0.0347 T23:    0.0273                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.3568 L22:    3.3277                                    
REMARK   3     L33:    3.0768 L12:    0.6995                                    
REMARK   3     L13:    0.0428 L23:   -0.0240                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.1151 S12:    0.1016 S13:    0.2923                     
REMARK   3     S21:    0.2187 S22:    0.0252 S23:    0.1800                     
REMARK   3     S31:   -0.2195 S32:   -0.4897 S33:   -0.1402                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 15                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 179 - 186)                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -39.4227  -20.0129   -1.7411           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.1574 T22:   -0.1085                                    
REMARK   3     T33:    0.0981 T12:   -0.1520                                    
REMARK   3     T13:   -0.1511 T23:    0.0010                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    1.1118 L22:    2.7507                                    
REMARK   3     L33:    0.8239 L12:    1.8381                                    
REMARK   3     L13:   -2.1376 L23:   -0.9891                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.0230 S12:    0.0619 S13:    0.0422                     
REMARK   3     S21:    0.0134 S22:    0.0800 S23:    0.0301                     
REMARK   3     S31:    0.0436 S32:   -0.0678 S33:   -0.0570                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 16                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 187 - 246)                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -39.5436   -8.2769   11.4855           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.0360 T22:   -0.0531                                    
REMARK   3     T33:   -0.0723 T12:    0.0459                                    
REMARK   3     T13:   -0.0097 T23:    0.0235                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    0.5306 L22:    1.1984                                    
REMARK   3     L33:    1.1888 L12:    0.1108                                    
REMARK   3     L13:    0.0622 L23:   -2.6265                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0121 S12:    0.0189 S13:    0.0179                     
REMARK   3     S21:    0.4965 S22:    0.2688 S23:    0.4756                     
REMARK   3     S31:   -0.2185 S32:   -0.5442 S33:   -0.2808                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 17                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 247 - 257)                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -48.3382    1.8129   18.0980           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:    0.0538 T22:    0.0433                                    
REMARK   3     T33:   -0.0449 T12:    0.1024                                    
REMARK   3     T13:    0.1520 T23:    0.1520                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    2.8807 L22:    0.0000                                    
REMARK   3     L33:    2.2666 L12:   -1.1365                                    
REMARK   3     L13:   -0.4917 L23:   -1.0062                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:   -0.0225 S12:   -0.0383 S13:    0.1146                     
REMARK   3     S21:    0.0429 S22:   -0.0598 S23:   -0.0124                     
REMARK   3     S31:   -0.0644 S32:    0.0056 S33:    0.0822                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 18                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 258 - 292)                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -52.8069   -0.7229    4.6583           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.2212 T22:    0.1627                                    
REMARK   3     T33:   -0.0060 T12:    0.0708                                    
REMARK   3     T13:    0.0496 T23:    0.1059                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    3.2495 L22:    1.5165                                    
REMARK   3     L33:    2.7522 L12:   -2.9104                                    
REMARK   3     L13:   -1.2829 L23:    0.9907                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0054 S12:    0.1323 S13:    0.0552                     
REMARK   3     S21:    0.1775 S22:    0.0974 S23:    0.4286                     
REMARK   3     S31:   -0.1689 S32:   -0.5423 S33:   -0.1028                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 19                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 11 - 55)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -26.6932   15.9233   45.2118           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.1578 T22:    0.0195                                    
REMARK   3     T33:   -0.1145 T12:    0.0380                                    
REMARK   3     T13:    0.0180 T23:   -0.0098                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    0.2669 L22:    4.8411                                    
REMARK   3     L33:    3.7281 L12:    0.9278                                    
REMARK   3     L13:   -0.0875 L23:   -0.3621                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0366 S12:    0.3491 S13:   -0.0594                     
REMARK   3     S21:    0.0698 S22:    0.1661 S23:   -0.0949                     
REMARK   3     S31:   -0.1686 S32:    0.3721 S33:   -0.2027                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 20                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 56 - 72)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   -4.8567   15.3474   45.9389           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.0400 T22:    0.1312                                    
REMARK   3     T33:    0.2247 T12:    0.0302                                    
REMARK   3     T13:   -0.0433 T23:    0.0755                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    1.7555 L22:    2.4302                                    
REMARK   3     L33:    1.4543 L12:   -1.9173                                    
REMARK   3     L13:   -0.1909 L23:    0.3748                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.0050 S12:    0.0469 S13:   -0.0267                     
REMARK   3     S21:    0.0255 S22:   -0.0018 S23:    0.0493                     
REMARK   3     S31:   -0.0255 S32:   -0.0133 S33:   -0.0032                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 21                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 73 - 111)                           
REMARK   3    ORIGIN FOR THE GROUP (A):  -19.8356   25.7850   42.6683           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.1273 T22:    0.0500                                    
REMARK   3     T33:   -0.1236 T12:   -0.0701                                    
REMARK   3     T13:   -0.0025 T23:   -0.0322                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    1.3729 L22:    0.9147                                    
REMARK   3     L33:    3.2483 L12:    0.5868                                    
REMARK   3     L13:   -2.9104 L23:   -1.1745                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.1081 S12:   -0.2461 S13:    0.2101                     
REMARK   3     S21:    0.0082 S22:    0.1626 S23:    0.1006                     
REMARK   3     S31:   -0.3901 S32:    0.4210 S33:   -0.2707                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 22                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 112 - 183)                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -19.4548   30.9288   27.3812           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.1851 T22:   -0.0131                                    
REMARK   3     T33:   -0.1184 T12:   -0.0229                                    
REMARK   3     T13:    0.0249 T23:    0.0708                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    8.3155 L22:    2.1522                                    
REMARK   3     L33:    4.1445 L12:    0.3133                                    
REMARK   3     L13:   -0.9866 L23:   -0.2099                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.2466 S12:    0.4758 S13:    0.5442                     
REMARK   3     S21:   -0.1090 S22:    0.0511 S23:    0.3700                     
REMARK   3     S31:   -0.2527 S32:   -0.5442 S33:   -0.2977                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 23                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 184 - 231)                          
REMARK   3    ORIGIN FOR THE GROUP (A):   -5.2456   30.5557   23.1368           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.0828 T22:    0.1403                                    
REMARK   3     T33:   -0.1128 T12:   -0.0142                                    
REMARK   3     T13:   -0.0388 T23:    0.0096                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    8.3155 L22:    0.5254                                    
REMARK   3     L33:    0.0261 L12:    2.6403                                    
REMARK   3     L13:   -2.3055 L23:    0.1159                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.1226 S12:    0.5299 S13:    0.1525                     
REMARK   3     S21:   -0.1127 S22:    0.0960 S23:    0.0360                     
REMARK   3     S31:   -0.1449 S32:   -0.1316 S33:   -0.2186                     
REMARK   3                                                                      
REMARK   3   TLS GROUP : 24                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 232 - 293)                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -11.9287   33.5418   13.5590           
REMARK   3    T TENSOR                                                          
REMARK   3     T11:   -0.3040 T22:    0.1526                                    
REMARK   3     T33:   -0.2687 T12:    0.0095                                    
REMARK   3     T13:   -0.0083 T23:    0.1520                                    
REMARK   3    L TENSOR                                                          
REMARK   3     L11:    7.8335 L22:    4.3395                                    
REMARK   3     L33:    8.3155 L12:   -0.4026                                    
REMARK   3     L13:   -2.9104 L23:   -1.1665                                    
REMARK   3    S TENSOR                                                          
REMARK   3     S11:    0.1222 S12:    0.5442 S13:    0.5217                     
REMARK   3     S21:   -0.2560 S22:    0.0227 S23:    0.2824                     
REMARK   3     S31:   -0.2240 S32:   -0.0795 S33:   -0.1448                     
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 2Y7J COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 31-JAN-11.                  
REMARK 100 THE DEPOSITION ID IS D_1290047206.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 08-DEC-10                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : NULL                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : DIAMOND                            
REMARK 200  BEAMLINE                       : I03                                
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9763                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC CCD                           
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM                             
REMARK 200  DATA SCALING SOFTWARE          : SCALA                              
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 46408                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.500                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 63.320                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 2.000                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.7                               
REMARK 200  DATA REDUNDANCY                : 3.500                              
REMARK 200  R MERGE                    (I) : 0.04000                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 9.5000                             
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.50                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.64                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 98.6                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.10                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.56000                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 2.000                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NONE                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 36.99                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 1.95                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 25% PEG 3350; 0.1 M BIS-TRIS 5.5         
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21                       
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X+1/2,-Y,Z+1/2                                         
REMARK 290       3555   -X,Y+1/2,-Z+1/2                                         
REMARK 290       4555   X+1/2,-Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       43.89500            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       82.24000            
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       45.71000            
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       82.24000            
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       43.89500            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       45.71000            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 5680 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 49220 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -33.1 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A   -71                                                      
REMARK 465     HIS A   -70                                                      
REMARK 465     HIS A   -69                                                      
REMARK 465     HIS A   -68                                                      
REMARK 465     HIS A   -67                                                      
REMARK 465     HIS A   -66                                                      
REMARK 465     HIS A   -65                                                      
REMARK 465     SER A   -64                                                      
REMARK 465     SER A   -63                                                      
REMARK 465     GLY A   -62                                                      
REMARK 465     VAL A   -61                                                      
REMARK 465     ASP A   -60                                                      
REMARK 465     ASN A   -59                                                      
REMARK 465     LYS A   -58                                                      
REMARK 465     PHE A   -57                                                      
REMARK 465     ASN A   -56                                                      
REMARK 465     LYS A   -55                                                      
REMARK 465     GLU A   -54                                                      
REMARK 465     ARG A   -53                                                      
REMARK 465     ARG A   -52                                                      
REMARK 465     ARG A   -51                                                      
REMARK 465     ALA A   -50                                                      
REMARK 465     ARG A   -49                                                      
REMARK 465     ARG A   -48                                                      
REMARK 465     GLU A   -47                                                      
REMARK 465     ILE A   -46                                                      
REMARK 465     ARG A   -45                                                      
REMARK 465     HIS A   -44                                                      
REMARK 465     LEU A   -43                                                      
REMARK 465     PRO A   -42                                                      
REMARK 465     ASN A   -41                                                      
REMARK 465     LEU A   -40                                                      
REMARK 465     ASN A   -39                                                      
REMARK 465     ARG A   -38                                                      
REMARK 465     GLU A   -37                                                      
REMARK 465     GLN A   -36                                                      
REMARK 465     ARG A   -35                                                      
REMARK 465     ARG A   -34                                                      
REMARK 465     ALA A   -33                                                      
REMARK 465     PHE A   -32                                                      
REMARK 465     ILE A   -31                                                      
REMARK 465     ARG A   -30                                                      
REMARK 465     SER A   -29                                                      
REMARK 465     LEU A   -28                                                      
REMARK 465     ARG A   -27                                                      
REMARK 465     ASP A   -26                                                      
REMARK 465     ASP A   -25                                                      
REMARK 465     PRO A   -24                                                      
REMARK 465     SER A   -23                                                      
REMARK 465     GLN A   -22                                                      
REMARK 465     SER A   -21                                                      
REMARK 465     ALA A   -20                                                      
REMARK 465     ASN A   -19                                                      
REMARK 465     LEU A   -18                                                      
REMARK 465     LEU A   -17                                                      
REMARK 465     ALA A   -16                                                      
REMARK 465     GLU A   -15                                                      
REMARK 465     ALA A   -14                                                      
REMARK 465     LYS A   -13                                                      
REMARK 465     LYS A   -12                                                      
REMARK 465     LEU A   -11                                                      
REMARK 465     ASN A   -10                                                      
REMARK 465     ASP A    -9                                                      
REMARK 465     ALA A    -8                                                      
REMARK 465     GLN A    -7                                                      
REMARK 465     PRO A    -6                                                      
REMARK 465     LYS A    -5                                                      
REMARK 465     GLY A    -4                                                      
REMARK 465     THR A    -3                                                      
REMARK 465     GLU A    -2                                                      
REMARK 465     ASN A    -1                                                      
REMARK 465     LEU A     0                                                      
REMARK 465     TYR A     1                                                      
REMARK 465     PHE A     2                                                      
REMARK 465     GLN A     3                                                      
REMARK 465     SER A     4                                                      
REMARK 465     MET A     5                                                      
REMARK 465     GLY A     6                                                      
REMARK 465     PRO A     7                                                      
REMARK 465     GLU A     8                                                      
REMARK 465     ASP A     9                                                      
REMARK 465     MET B   -71                                                      
REMARK 465     HIS B   -70                                                      
REMARK 465     HIS B   -69                                                      
REMARK 465     HIS B   -68                                                      
REMARK 465     HIS B   -67                                                      
REMARK 465     HIS B   -66                                                      
REMARK 465     HIS B   -65                                                      
REMARK 465     SER B   -64                                                      
REMARK 465     SER B   -63                                                      
REMARK 465     GLY B   -62                                                      
REMARK 465     VAL B   -61                                                      
REMARK 465     ASP B   -60                                                      
REMARK 465     ASN B   -59                                                      
REMARK 465     LYS B   -58                                                      
REMARK 465     PHE B   -57                                                      
REMARK 465     ASN B   -56                                                      
REMARK 465     LYS B   -55                                                      
REMARK 465     GLU B   -54                                                      
REMARK 465     ARG B   -53                                                      
REMARK 465     ARG B   -52                                                      
REMARK 465     ARG B   -51                                                      
REMARK 465     ALA B   -50                                                      
REMARK 465     ARG B   -49                                                      
REMARK 465     ARG B   -48                                                      
REMARK 465     GLU B   -47                                                      
REMARK 465     ILE B   -46                                                      
REMARK 465     ARG B   -45                                                      
REMARK 465     HIS B   -44                                                      
REMARK 465     LEU B   -43                                                      
REMARK 465     PRO B   -42                                                      
REMARK 465     ASN B   -41                                                      
REMARK 465     LEU B   -40                                                      
REMARK 465     ASN B   -39                                                      
REMARK 465     ARG B   -38                                                      
REMARK 465     GLU B   -37                                                      
REMARK 465     GLN B   -36                                                      
REMARK 465     ARG B   -35                                                      
REMARK 465     ARG B   -34                                                      
REMARK 465     ALA B   -33                                                      
REMARK 465     PHE B   -32                                                      
REMARK 465     ILE B   -31                                                      
REMARK 465     ARG B   -30                                                      
REMARK 465     SER B   -29                                                      
REMARK 465     LEU B   -28                                                      
REMARK 465     ARG B   -27                                                      
REMARK 465     ASP B   -26                                                      
REMARK 465     ASP B   -25                                                      
REMARK 465     PRO B   -24                                                      
REMARK 465     SER B   -23                                                      
REMARK 465     GLN B   -22                                                      
REMARK 465     SER B   -21                                                      
REMARK 465     ALA B   -20                                                      
REMARK 465     ASN B   -19                                                      
REMARK 465     LEU B   -18                                                      
REMARK 465     LEU B   -17                                                      
REMARK 465     ALA B   -16                                                      
REMARK 465     GLU B   -15                                                      
REMARK 465     ALA B   -14                                                      
REMARK 465     LYS B   -13                                                      
REMARK 465     LYS B   -12                                                      
REMARK 465     LEU B   -11                                                      
REMARK 465     ASN B   -10                                                      
REMARK 465     ASP B    -9                                                      
REMARK 465     ALA B    -8                                                      
REMARK 465     GLN B    -7                                                      
REMARK 465     PRO B    -6                                                      
REMARK 465     LYS B    -5                                                      
REMARK 465     GLY B    -4                                                      
REMARK 465     THR B    -3                                                      
REMARK 465     GLU B    -2                                                      
REMARK 465     ASN B    -1                                                      
REMARK 465     LEU B     0                                                      
REMARK 465     TYR B     1                                                      
REMARK 465     PHE B     2                                                      
REMARK 465     GLN B     3                                                      
REMARK 465     SER B     4                                                      
REMARK 465     MET B     5                                                      
REMARK 465     GLY B     6                                                      
REMARK 465     PRO B     7                                                      
REMARK 465     GLU B     8                                                      
REMARK 465     ASP B     9                                                      
REMARK 465     GLU B    60                                                      
REMARK 465     ARG B    61                                                      
REMARK 465     LEU B    62                                                      
REMARK 465     MET C   -71                                                      
REMARK 465     HIS C   -70                                                      
REMARK 465     HIS C   -69                                                      
REMARK 465     HIS C   -68                                                      
REMARK 465     HIS C   -67                                                      
REMARK 465     HIS C   -66                                                      
REMARK 465     HIS C   -65                                                      
REMARK 465     SER C   -64                                                      
REMARK 465     SER C   -63                                                      
REMARK 465     GLY C   -62                                                      
REMARK 465     VAL C   -61                                                      
REMARK 465     ASP C   -60                                                      
REMARK 465     ASN C   -59                                                      
REMARK 465     LYS C   -58                                                      
REMARK 465     PHE C   -57                                                      
REMARK 465     ASN C   -56                                                      
REMARK 465     LYS C   -55                                                      
REMARK 465     GLU C   -54                                                      
REMARK 465     ARG C   -53                                                      
REMARK 465     ARG C   -52                                                      
REMARK 465     ARG C   -51                                                      
REMARK 465     ALA C   -50                                                      
REMARK 465     ARG C   -49                                                      
REMARK 465     ARG C   -48                                                      
REMARK 465     GLU C   -47                                                      
REMARK 465     ILE C   -46                                                      
REMARK 465     ARG C   -45                                                      
REMARK 465     HIS C   -44                                                      
REMARK 465     LEU C   -43                                                      
REMARK 465     PRO C   -42                                                      
REMARK 465     ASN C   -41                                                      
REMARK 465     LEU C   -40                                                      
REMARK 465     ASN C   -39                                                      
REMARK 465     ARG C   -38                                                      
REMARK 465     GLU C   -37                                                      
REMARK 465     GLN C   -36                                                      
REMARK 465     ARG C   -35                                                      
REMARK 465     ARG C   -34                                                      
REMARK 465     ALA C   -33                                                      
REMARK 465     PHE C   -32                                                      
REMARK 465     ILE C   -31                                                      
REMARK 465     ARG C   -30                                                      
REMARK 465     SER C   -29                                                      
REMARK 465     LEU C   -28                                                      
REMARK 465     ARG C   -27                                                      
REMARK 465     ASP C   -26                                                      
REMARK 465     ASP C   -25                                                      
REMARK 465     PRO C   -24                                                      
REMARK 465     SER C   -23                                                      
REMARK 465     GLN C   -22                                                      
REMARK 465     SER C   -21                                                      
REMARK 465     ALA C   -20                                                      
REMARK 465     ASN C   -19                                                      
REMARK 465     LEU C   -18                                                      
REMARK 465     LEU C   -17                                                      
REMARK 465     ALA C   -16                                                      
REMARK 465     GLU C   -15                                                      
REMARK 465     ALA C   -14                                                      
REMARK 465     LYS C   -13                                                      
REMARK 465     LYS C   -12                                                      
REMARK 465     LEU C   -11                                                      
REMARK 465     ASN C   -10                                                      
REMARK 465     ASP C    -9                                                      
REMARK 465     ALA C    -8                                                      
REMARK 465     GLN C    -7                                                      
REMARK 465     PRO C    -6                                                      
REMARK 465     LYS C    -5                                                      
REMARK 465     GLY C    -4                                                      
REMARK 465     THR C    -3                                                      
REMARK 465     GLU C    -2                                                      
REMARK 465     ASN C    -1                                                      
REMARK 465     LEU C     0                                                      
REMARK 465     TYR C     1                                                      
REMARK 465     PHE C     2                                                      
REMARK 465     GLN C     3                                                      
REMARK 465     SER C     4                                                      
REMARK 465     MET C     5                                                      
REMARK 465     GLY C     6                                                      
REMARK 465     PRO C     7                                                      
REMARK 465     GLU C     8                                                      
REMARK 465     ASP C     9                                                      
REMARK 465     MET D   -71                                                      
REMARK 465     HIS D   -70                                                      
REMARK 465     HIS D   -69                                                      
REMARK 465     HIS D   -68                                                      
REMARK 465     HIS D   -67                                                      
REMARK 465     HIS D   -66                                                      
REMARK 465     HIS D   -65                                                      
REMARK 465     SER D   -64                                                      
REMARK 465     SER D   -63                                                      
REMARK 465     GLY D   -62                                                      
REMARK 465     VAL D   -61                                                      
REMARK 465     ASP D   -60                                                      
REMARK 465     ASN D   -59                                                      
REMARK 465     LYS D   -58                                                      
REMARK 465     PHE D   -57                                                      
REMARK 465     ASN D   -56                                                      
REMARK 465     LYS D   -55                                                      
REMARK 465     GLU D   -54                                                      
REMARK 465     ARG D   -53                                                      
REMARK 465     ARG D   -52                                                      
REMARK 465     ARG D   -51                                                      
REMARK 465     ALA D   -50                                                      
REMARK 465     ARG D   -49                                                      
REMARK 465     ARG D   -48                                                      
REMARK 465     GLU D   -47                                                      
REMARK 465     ILE D   -46                                                      
REMARK 465     ARG D   -45                                                      
REMARK 465     HIS D   -44                                                      
REMARK 465     LEU D   -43                                                      
REMARK 465     PRO D   -42                                                      
REMARK 465     ASN D   -41                                                      
REMARK 465     LEU D   -40                                                      
REMARK 465     ASN D   -39                                                      
REMARK 465     ARG D   -38                                                      
REMARK 465     GLU D   -37                                                      
REMARK 465     GLN D   -36                                                      
REMARK 465     ARG D   -35                                                      
REMARK 465     ARG D   -34                                                      
REMARK 465     ALA D   -33                                                      
REMARK 465     PHE D   -32                                                      
REMARK 465     ILE D   -31                                                      
REMARK 465     ARG D   -30                                                      
REMARK 465     SER D   -29                                                      
REMARK 465     LEU D   -28                                                      
REMARK 465     ARG D   -27                                                      
REMARK 465     ASP D   -26                                                      
REMARK 465     ASP D   -25                                                      
REMARK 465     PRO D   -24                                                      
REMARK 465     SER D   -23                                                      
REMARK 465     GLN D   -22                                                      
REMARK 465     SER D   -21                                                      
REMARK 465     ALA D   -20                                                      
REMARK 465     ASN D   -19                                                      
REMARK 465     LEU D   -18                                                      
REMARK 465     LEU D   -17                                                      
REMARK 465     ALA D   -16                                                      
REMARK 465     GLU D   -15                                                      
REMARK 465     ALA D   -14                                                      
REMARK 465     LYS D   -13                                                      
REMARK 465     LYS D   -12                                                      
REMARK 465     LEU D   -11                                                      
REMARK 465     ASN D   -10                                                      
REMARK 465     ASP D    -9                                                      
REMARK 465     ALA D    -8                                                      
REMARK 465     GLN D    -7                                                      
REMARK 465     PRO D    -6                                                      
REMARK 465     LYS D    -5                                                      
REMARK 465     GLY D    -4                                                      
REMARK 465     THR D    -3                                                      
REMARK 465     GLU D    -2                                                      
REMARK 465     ASN D    -1                                                      
REMARK 465     LEU D     0                                                      
REMARK 465     TYR D     1                                                      
REMARK 465     PHE D     2                                                      
REMARK 465     GLN D     3                                                      
REMARK 465     SER D     4                                                      
REMARK 465     MET D     5                                                      
REMARK 465     GLY D     6                                                      
REMARK 465     PRO D     7                                                      
REMARK 465     GLU D     8                                                      
REMARK 465     ASP D     9                                                      
REMARK 465     THR D    58                                                      
REMARK 465     ALA D    59                                                      
REMARK 465     GLU D    60                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ARG A  61    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER A  63    OG                                                  
REMARK 470     LYS A 128    CG   CD   CE   NZ                                   
REMARK 470     ASP A 204    CG   OD1  OD2                                       
REMARK 470     ARG A 236    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A 256    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 258    CG   OD1  OD2                                       
REMARK 470     ASP A 259    CG   OD1  OD2                                       
REMARK 470     SER A 269    OG                                                  
REMARK 470     GLU A 292    CD   OE1  OE2                                       
REMARK 470     ARG A 293    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU B  10    CG   CD   OE1  OE2                                  
REMARK 470     LEU B  11    CG   CD1  CD2                                       
REMARK 470     VAL B  34    CG1  CG2                                            
REMARK 470     GLN B  66    CG   CD   OE1  NE2                                  
REMARK 470     LEU B  67    CG   CD1  CD2                                       
REMARK 470     ARG B  71    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     MET B 103    CG   SD   CE                                        
REMARK 470     GLU B 179    CG   CD   OE1  OE2                                  
REMARK 470     HIS B 235    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ARG B 236    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B 237    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN B 238    CG   CD   OE1  NE2                                  
REMARK 470     ILE B 239    CG1  CG2  CD1                                       
REMARK 470     LEU B 240    CG   CD1  CD2                                       
REMARK 470     ARG B 243    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN B 249    CG   CD   OE1  NE2                                  
REMARK 470     SER B 254    OG                                                  
REMARK 470     SER B 269    OG                                                  
REMARK 470     LYS C  18    CE   NZ                                             
REMARK 470     ARG C  61    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C  65    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 200    CD   CE   NZ                                        
REMARK 470     ARG C 236    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG C 243    NE   CZ   NH1  NH2                                  
REMARK 470     GLN C 251    CG   CD   OE1  NE2                                  
REMARK 470     GLU C 256    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 258    CG   OD1  OD2                                       
REMARK 470     SER C 269    OG                                                  
REMARK 470     GLU C 277    CD   OE1  OE2                                       
REMARK 470     ARG C 293    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU D  10    CG   CD   OE1  OE2                                  
REMARK 470     VAL D  57    CG1  CG2                                            
REMARK 470     ARG D  61    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU D  62    CG   CD1  CD2                                       
REMARK 470     GLU D  65    CG   CD   OE1  OE2                                  
REMARK 470     GLN D  66    CG   CD   OE1  NE2                                  
REMARK 470     SER D 100    OG                                                  
REMARK 470     LYS D 122    CG   CD   CE   NZ                                   
REMARK 470     ARG D 236    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN D 238    CG   CD   OE1  NE2                                  
REMARK 470     LEU D 240    CG   CD1  CD2                                       
REMARK 470     ARG D 243    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU D 247    CG   CD   OE1  OE2                                  
REMARK 470     GLN D 249    CD   OE1  NE2                                       
REMARK 470     SER D 254    OG                                                  
REMARK 470     ASP D 258    CG   OD1  OD2                                       
REMARK 470     LYS D 265    CG   CD   CE   NZ                                   
REMARK 470     SER D 269    OG                                                  
REMARK 470     GLU D 292    CG   CD   OE1  OE2                                  
REMARK 470     ARG D 293    CG   CD   NE   CZ   NH1  NH2                        
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS                                             
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC             
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15          
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A           
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375             
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE               
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.            
REMARK 500                                                                      
REMARK 500 DISTANCE CUTOFF:                                                     
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS              
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS                  
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE          
REMARK 500   O    PRO A   208     O    ALA D    45     3445     2.11            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LYS A  27     -140.21   -117.67                                   
REMARK 500    VAL A 123      -58.44     75.12                                   
REMARK 500    ASP A 153       44.98   -164.47                                   
REMARK 500    ASP A 171       70.88     54.75                                   
REMARK 500    MET A 203      -19.62   -151.54                                   
REMARK 500    LYS B  27     -145.15   -123.81                                   
REMARK 500    VAL B  57       54.54    -96.24                                   
REMARK 500    THR B  58        1.91   -163.59                                   
REMARK 500    VAL B 123      -60.32     75.52                                   
REMARK 500    ASP B 153       41.00   -150.42                                   
REMARK 500    ASP B 171       72.46     48.31                                   
REMARK 500    MET B 203      -74.71    -90.05                                   
REMARK 500    PRO B 289       -8.34    -57.36                                   
REMARK 500    LYS C  27     -139.62   -119.23                                   
REMARK 500    VAL C 123      -59.15     74.37                                   
REMARK 500    ASP C 153       41.54   -158.82                                   
REMARK 500    SER C 170     -166.61   -128.01                                   
REMARK 500    ASP C 171       75.18     49.58                                   
REMARK 500    LYS D  27     -150.10   -117.63                                   
REMARK 500    VAL D 123      -58.90     74.87                                   
REMARK 500    ASP D 153       41.93   -149.06                                   
REMARK 500    ASP D 171       74.24     54.45                                   
REMARK 500    ASP D 259       45.46    -95.80                                   
REMARK 500    LEU D 272       55.08    -93.24                                   
REMARK 500    PRO D 289       -7.01    -58.48                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE B49 A 1294                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE B49 B 1294                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE B49 C 1294                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE B49 D 1294                
DBREF  2Y7J A    6   293  UNP    P15735   PHKG2_HUMAN      6    293             
DBREF  2Y7J B    6   293  UNP    P15735   PHKG2_HUMAN      6    293             
DBREF  2Y7J C    6   293  UNP    P15735   PHKG2_HUMAN      6    293             
DBREF  2Y7J D    6   293  UNP    P15735   PHKG2_HUMAN      6    293             
SEQADV 2Y7J MET A  -71  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS A  -70  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS A  -69  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS A  -68  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS A  -67  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS A  -66  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS A  -65  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER A  -64  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER A  -63  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLY A  -62  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J VAL A  -61  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASP A  -60  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN A  -59  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS A  -58  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PHE A  -57  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN A  -56  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS A  -55  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU A  -54  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG A  -53  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG A  -52  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG A  -51  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA A  -50  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG A  -49  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG A  -48  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU A  -47  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ILE A  -46  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG A  -45  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS A  -44  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU A  -43  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PRO A  -42  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN A  -41  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU A  -40  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN A  -39  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG A  -38  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU A  -37  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLN A  -36  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG A  -35  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG A  -34  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA A  -33  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PHE A  -32  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ILE A  -31  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG A  -30  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER A  -29  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU A  -28  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG A  -27  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASP A  -26  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASP A  -25  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PRO A  -24  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER A  -23  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLN A  -22  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER A  -21  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA A  -20  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN A  -19  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU A  -18  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU A  -17  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA A  -16  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU A  -15  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA A  -14  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS A  -13  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS A  -12  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU A  -11  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN A  -10  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASP A   -9  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA A   -8  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLN A   -7  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PRO A   -6  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS A   -5  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLY A   -4  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J THR A   -3  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU A   -2  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN A   -1  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU A    0  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J TYR A    1  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PHE A    2  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLN A    3  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER A    4  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J MET A    5  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J MET B  -71  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS B  -70  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS B  -69  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS B  -68  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS B  -67  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS B  -66  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS B  -65  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER B  -64  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER B  -63  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLY B  -62  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J VAL B  -61  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASP B  -60  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN B  -59  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS B  -58  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PHE B  -57  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN B  -56  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS B  -55  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU B  -54  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG B  -53  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG B  -52  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG B  -51  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA B  -50  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG B  -49  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG B  -48  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU B  -47  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ILE B  -46  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG B  -45  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS B  -44  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU B  -43  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PRO B  -42  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN B  -41  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU B  -40  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN B  -39  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG B  -38  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU B  -37  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLN B  -36  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG B  -35  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG B  -34  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA B  -33  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PHE B  -32  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ILE B  -31  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG B  -30  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER B  -29  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU B  -28  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG B  -27  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASP B  -26  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASP B  -25  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PRO B  -24  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER B  -23  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLN B  -22  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER B  -21  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA B  -20  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN B  -19  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU B  -18  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU B  -17  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA B  -16  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU B  -15  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA B  -14  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS B  -13  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS B  -12  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU B  -11  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN B  -10  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASP B   -9  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA B   -8  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLN B   -7  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PRO B   -6  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS B   -5  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLY B   -4  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J THR B   -3  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU B   -2  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN B   -1  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU B    0  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J TYR B    1  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PHE B    2  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLN B    3  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER B    4  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J MET B    5  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J MET C  -71  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS C  -70  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS C  -69  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS C  -68  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS C  -67  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS C  -66  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS C  -65  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER C  -64  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER C  -63  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLY C  -62  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J VAL C  -61  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASP C  -60  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN C  -59  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS C  -58  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PHE C  -57  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN C  -56  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS C  -55  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU C  -54  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG C  -53  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG C  -52  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG C  -51  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA C  -50  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG C  -49  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG C  -48  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU C  -47  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ILE C  -46  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG C  -45  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS C  -44  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU C  -43  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PRO C  -42  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN C  -41  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU C  -40  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN C  -39  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG C  -38  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU C  -37  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLN C  -36  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG C  -35  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG C  -34  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA C  -33  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PHE C  -32  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ILE C  -31  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG C  -30  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER C  -29  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU C  -28  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG C  -27  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASP C  -26  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASP C  -25  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PRO C  -24  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER C  -23  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLN C  -22  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER C  -21  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA C  -20  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN C  -19  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU C  -18  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU C  -17  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA C  -16  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU C  -15  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA C  -14  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS C  -13  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS C  -12  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU C  -11  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN C  -10  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASP C   -9  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA C   -8  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLN C   -7  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PRO C   -6  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS C   -5  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLY C   -4  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J THR C   -3  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU C   -2  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN C   -1  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU C    0  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J TYR C    1  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PHE C    2  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLN C    3  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER C    4  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J MET C    5  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J MET D  -71  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS D  -70  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS D  -69  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS D  -68  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS D  -67  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS D  -66  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS D  -65  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER D  -64  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER D  -63  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLY D  -62  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J VAL D  -61  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASP D  -60  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN D  -59  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS D  -58  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PHE D  -57  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN D  -56  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS D  -55  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU D  -54  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG D  -53  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG D  -52  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG D  -51  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA D  -50  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG D  -49  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG D  -48  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU D  -47  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ILE D  -46  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG D  -45  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J HIS D  -44  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU D  -43  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PRO D  -42  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN D  -41  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU D  -40  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN D  -39  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG D  -38  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU D  -37  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLN D  -36  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG D  -35  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG D  -34  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA D  -33  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PHE D  -32  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ILE D  -31  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG D  -30  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER D  -29  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU D  -28  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ARG D  -27  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASP D  -26  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASP D  -25  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PRO D  -24  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER D  -23  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLN D  -22  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER D  -21  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA D  -20  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN D  -19  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU D  -18  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU D  -17  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA D  -16  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU D  -15  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA D  -14  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS D  -13  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS D  -12  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU D  -11  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN D  -10  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASP D   -9  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ALA D   -8  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLN D   -7  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PRO D   -6  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LYS D   -5  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLY D   -4  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J THR D   -3  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLU D   -2  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J ASN D   -1  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J LEU D    0  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J TYR D    1  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J PHE D    2  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J GLN D    3  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J SER D    4  UNP  P15735              EXPRESSION TAG                 
SEQADV 2Y7J MET D    5  UNP  P15735              EXPRESSION TAG                 
SEQRES   1 A  365  MET HIS HIS HIS HIS HIS HIS SER SER GLY VAL ASP ASN          
SEQRES   2 A  365  LYS PHE ASN LYS GLU ARG ARG ARG ALA ARG ARG GLU ILE          
SEQRES   3 A  365  ARG HIS LEU PRO ASN LEU ASN ARG GLU GLN ARG ARG ALA          
SEQRES   4 A  365  PHE ILE ARG SER LEU ARG ASP ASP PRO SER GLN SER ALA          
SEQRES   5 A  365  ASN LEU LEU ALA GLU ALA LYS LYS LEU ASN ASP ALA GLN          
SEQRES   6 A  365  PRO LYS GLY THR GLU ASN LEU TYR PHE GLN SER MET GLY          
SEQRES   7 A  365  PRO GLU ASP GLU LEU PRO ASP TRP ALA ALA ALA LYS GLU          
SEQRES   8 A  365  PHE TYR GLN LYS TYR ASP PRO LYS ASP VAL ILE GLY ARG          
SEQRES   9 A  365  GLY VAL SER SER VAL VAL ARG ARG CYS VAL HIS ARG ALA          
SEQRES  10 A  365  THR GLY HIS GLU PHE ALA VAL LYS ILE MET GLU VAL THR          
SEQRES  11 A  365  ALA GLU ARG LEU SER PRO GLU GLN LEU GLU GLU VAL ARG          
SEQRES  12 A  365  GLU ALA THR ARG ARG GLU THR HIS ILE LEU ARG GLN VAL          
SEQRES  13 A  365  ALA GLY HIS PRO HIS ILE ILE THR LEU ILE ASP SER TYR          
SEQRES  14 A  365  GLU SER SER SER PHE MET PHE LEU VAL PHE ASP LEU MET          
SEQRES  15 A  365  ARG LYS GLY GLU LEU PHE ASP TYR LEU THR GLU LYS VAL          
SEQRES  16 A  365  ALA LEU SER GLU LYS GLU THR ARG SER ILE MET ARG SER          
SEQRES  17 A  365  LEU LEU GLU ALA VAL SER PHE LEU HIS ALA ASN ASN ILE          
SEQRES  18 A  365  VAL HIS ARG ASP LEU LYS PRO GLU ASN ILE LEU LEU ASP          
SEQRES  19 A  365  ASP ASN MET GLN ILE ARG LEU SER ASP PHE GLY PHE SER          
SEQRES  20 A  365  CYS HIS LEU GLU PRO GLY GLU LYS LEU ARG GLU LEU CYS          
SEQRES  21 A  365  GLY THR PRO GLY TYR LEU ALA PRO GLU ILE LEU LYS CYS          
SEQRES  22 A  365  SER MET ASP GLU THR HIS PRO GLY TYR GLY LYS GLU VAL          
SEQRES  23 A  365  ASP LEU TRP ALA CYS GLY VAL ILE LEU PHE THR LEU LEU          
SEQRES  24 A  365  ALA GLY SER PRO PRO PHE TRP HIS ARG ARG GLN ILE LEU          
SEQRES  25 A  365  MET LEU ARG MET ILE MET GLU GLY GLN TYR GLN PHE SER          
SEQRES  26 A  365  SER PRO GLU TRP ASP ASP ARG SER SER THR VAL LYS ASP          
SEQRES  27 A  365  LEU ILE SER ARG LEU LEU GLN VAL ASP PRO GLU ALA ARG          
SEQRES  28 A  365  LEU THR ALA GLU GLN ALA LEU GLN HIS PRO PHE PHE GLU          
SEQRES  29 A  365  ARG                                                          
SEQRES   1 B  365  MET HIS HIS HIS HIS HIS HIS SER SER GLY VAL ASP ASN          
SEQRES   2 B  365  LYS PHE ASN LYS GLU ARG ARG ARG ALA ARG ARG GLU ILE          
SEQRES   3 B  365  ARG HIS LEU PRO ASN LEU ASN ARG GLU GLN ARG ARG ALA          
SEQRES   4 B  365  PHE ILE ARG SER LEU ARG ASP ASP PRO SER GLN SER ALA          
SEQRES   5 B  365  ASN LEU LEU ALA GLU ALA LYS LYS LEU ASN ASP ALA GLN          
SEQRES   6 B  365  PRO LYS GLY THR GLU ASN LEU TYR PHE GLN SER MET GLY          
SEQRES   7 B  365  PRO GLU ASP GLU LEU PRO ASP TRP ALA ALA ALA LYS GLU          
SEQRES   8 B  365  PHE TYR GLN LYS TYR ASP PRO LYS ASP VAL ILE GLY ARG          
SEQRES   9 B  365  GLY VAL SER SER VAL VAL ARG ARG CYS VAL HIS ARG ALA          
SEQRES  10 B  365  THR GLY HIS GLU PHE ALA VAL LYS ILE MET GLU VAL THR          
SEQRES  11 B  365  ALA GLU ARG LEU SER PRO GLU GLN LEU GLU GLU VAL ARG          
SEQRES  12 B  365  GLU ALA THR ARG ARG GLU THR HIS ILE LEU ARG GLN VAL          
SEQRES  13 B  365  ALA GLY HIS PRO HIS ILE ILE THR LEU ILE ASP SER TYR          
SEQRES  14 B  365  GLU SER SER SER PHE MET PHE LEU VAL PHE ASP LEU MET          
SEQRES  15 B  365  ARG LYS GLY GLU LEU PHE ASP TYR LEU THR GLU LYS VAL          
SEQRES  16 B  365  ALA LEU SER GLU LYS GLU THR ARG SER ILE MET ARG SER          
SEQRES  17 B  365  LEU LEU GLU ALA VAL SER PHE LEU HIS ALA ASN ASN ILE          
SEQRES  18 B  365  VAL HIS ARG ASP LEU LYS PRO GLU ASN ILE LEU LEU ASP          
SEQRES  19 B  365  ASP ASN MET GLN ILE ARG LEU SER ASP PHE GLY PHE SER          
SEQRES  20 B  365  CYS HIS LEU GLU PRO GLY GLU LYS LEU ARG GLU LEU CYS          
SEQRES  21 B  365  GLY THR PRO GLY TYR LEU ALA PRO GLU ILE LEU LYS CYS          
SEQRES  22 B  365  SER MET ASP GLU THR HIS PRO GLY TYR GLY LYS GLU VAL          
SEQRES  23 B  365  ASP LEU TRP ALA CYS GLY VAL ILE LEU PHE THR LEU LEU          
SEQRES  24 B  365  ALA GLY SER PRO PRO PHE TRP HIS ARG ARG GLN ILE LEU          
SEQRES  25 B  365  MET LEU ARG MET ILE MET GLU GLY GLN TYR GLN PHE SER          
SEQRES  26 B  365  SER PRO GLU TRP ASP ASP ARG SER SER THR VAL LYS ASP          
SEQRES  27 B  365  LEU ILE SER ARG LEU LEU GLN VAL ASP PRO GLU ALA ARG          
SEQRES  28 B  365  LEU THR ALA GLU GLN ALA LEU GLN HIS PRO PHE PHE GLU          
SEQRES  29 B  365  ARG                                                          
SEQRES   1 C  365  MET HIS HIS HIS HIS HIS HIS SER SER GLY VAL ASP ASN          
SEQRES   2 C  365  LYS PHE ASN LYS GLU ARG ARG ARG ALA ARG ARG GLU ILE          
SEQRES   3 C  365  ARG HIS LEU PRO ASN LEU ASN ARG GLU GLN ARG ARG ALA          
SEQRES   4 C  365  PHE ILE ARG SER LEU ARG ASP ASP PRO SER GLN SER ALA          
SEQRES   5 C  365  ASN LEU LEU ALA GLU ALA LYS LYS LEU ASN ASP ALA GLN          
SEQRES   6 C  365  PRO LYS GLY THR GLU ASN LEU TYR PHE GLN SER MET GLY          
SEQRES   7 C  365  PRO GLU ASP GLU LEU PRO ASP TRP ALA ALA ALA LYS GLU          
SEQRES   8 C  365  PHE TYR GLN LYS TYR ASP PRO LYS ASP VAL ILE GLY ARG          
SEQRES   9 C  365  GLY VAL SER SER VAL VAL ARG ARG CYS VAL HIS ARG ALA          
SEQRES  10 C  365  THR GLY HIS GLU PHE ALA VAL LYS ILE MET GLU VAL THR          
SEQRES  11 C  365  ALA GLU ARG LEU SER PRO GLU GLN LEU GLU GLU VAL ARG          
SEQRES  12 C  365  GLU ALA THR ARG ARG GLU THR HIS ILE LEU ARG GLN VAL          
SEQRES  13 C  365  ALA GLY HIS PRO HIS ILE ILE THR LEU ILE ASP SER TYR          
SEQRES  14 C  365  GLU SER SER SER PHE MET PHE LEU VAL PHE ASP LEU MET          
SEQRES  15 C  365  ARG LYS GLY GLU LEU PHE ASP TYR LEU THR GLU LYS VAL          
SEQRES  16 C  365  ALA LEU SER GLU LYS GLU THR ARG SER ILE MET ARG SER          
SEQRES  17 C  365  LEU LEU GLU ALA VAL SER PHE LEU HIS ALA ASN ASN ILE          
SEQRES  18 C  365  VAL HIS ARG ASP LEU LYS PRO GLU ASN ILE LEU LEU ASP          
SEQRES  19 C  365  ASP ASN MET GLN ILE ARG LEU SER ASP PHE GLY PHE SER          
SEQRES  20 C  365  CYS HIS LEU GLU PRO GLY GLU LYS LEU ARG GLU LEU CYS          
SEQRES  21 C  365  GLY THR PRO GLY TYR LEU ALA PRO GLU ILE LEU LYS CYS          
SEQRES  22 C  365  SER MET ASP GLU THR HIS PRO GLY TYR GLY LYS GLU VAL          
SEQRES  23 C  365  ASP LEU TRP ALA CYS GLY VAL ILE LEU PHE THR LEU LEU          
SEQRES  24 C  365  ALA GLY SER PRO PRO PHE TRP HIS ARG ARG GLN ILE LEU          
SEQRES  25 C  365  MET LEU ARG MET ILE MET GLU GLY GLN TYR GLN PHE SER          
SEQRES  26 C  365  SER PRO GLU TRP ASP ASP ARG SER SER THR VAL LYS ASP          
SEQRES  27 C  365  LEU ILE SER ARG LEU LEU GLN VAL ASP PRO GLU ALA ARG          
SEQRES  28 C  365  LEU THR ALA GLU GLN ALA LEU GLN HIS PRO PHE PHE GLU          
SEQRES  29 C  365  ARG                                                          
SEQRES   1 D  365  MET HIS HIS HIS HIS HIS HIS SER SER GLY VAL ASP ASN          
SEQRES   2 D  365  LYS PHE ASN LYS GLU ARG ARG ARG ALA ARG ARG GLU ILE          
SEQRES   3 D  365  ARG HIS LEU PRO ASN LEU ASN ARG GLU GLN ARG ARG ALA          
SEQRES   4 D  365  PHE ILE ARG SER LEU ARG ASP ASP PRO SER GLN SER ALA          
SEQRES   5 D  365  ASN LEU LEU ALA GLU ALA LYS LYS LEU ASN ASP ALA GLN          
SEQRES   6 D  365  PRO LYS GLY THR GLU ASN LEU TYR PHE GLN SER MET GLY          
SEQRES   7 D  365  PRO GLU ASP GLU LEU PRO ASP TRP ALA ALA ALA LYS GLU          
SEQRES   8 D  365  PHE TYR GLN LYS TYR ASP PRO LYS ASP VAL ILE GLY ARG          
SEQRES   9 D  365  GLY VAL SER SER VAL VAL ARG ARG CYS VAL HIS ARG ALA          
SEQRES  10 D  365  THR GLY HIS GLU PHE ALA VAL LYS ILE MET GLU VAL THR          
SEQRES  11 D  365  ALA GLU ARG LEU SER PRO GLU GLN LEU GLU GLU VAL ARG          
SEQRES  12 D  365  GLU ALA THR ARG ARG GLU THR HIS ILE LEU ARG GLN VAL          
SEQRES  13 D  365  ALA GLY HIS PRO HIS ILE ILE THR LEU ILE ASP SER TYR          
SEQRES  14 D  365  GLU SER SER SER PHE MET PHE LEU VAL PHE ASP LEU MET          
SEQRES  15 D  365  ARG LYS GLY GLU LEU PHE ASP TYR LEU THR GLU LYS VAL          
SEQRES  16 D  365  ALA LEU SER GLU LYS GLU THR ARG SER ILE MET ARG SER          
SEQRES  17 D  365  LEU LEU GLU ALA VAL SER PHE LEU HIS ALA ASN ASN ILE          
SEQRES  18 D  365  VAL HIS ARG ASP LEU LYS PRO GLU ASN ILE LEU LEU ASP          
SEQRES  19 D  365  ASP ASN MET GLN ILE ARG LEU SER ASP PHE GLY PHE SER          
SEQRES  20 D  365  CYS HIS LEU GLU PRO GLY GLU LYS LEU ARG GLU LEU CYS          
SEQRES  21 D  365  GLY THR PRO GLY TYR LEU ALA PRO GLU ILE LEU LYS CYS          
SEQRES  22 D  365  SER MET ASP GLU THR HIS PRO GLY TYR GLY LYS GLU VAL          
SEQRES  23 D  365  ASP LEU TRP ALA CYS GLY VAL ILE LEU PHE THR LEU LEU          
SEQRES  24 D  365  ALA GLY SER PRO PRO PHE TRP HIS ARG ARG GLN ILE LEU          
SEQRES  25 D  365  MET LEU ARG MET ILE MET GLU GLY GLN TYR GLN PHE SER          
SEQRES  26 D  365  SER PRO GLU TRP ASP ASP ARG SER SER THR VAL LYS ASP          
SEQRES  27 D  365  LEU ILE SER ARG LEU LEU GLN VAL ASP PRO GLU ALA ARG          
SEQRES  28 D  365  LEU THR ALA GLU GLN ALA LEU GLN HIS PRO PHE PHE GLU          
SEQRES  29 D  365  ARG                                                          
HET    B49  A1294      29                                                       
HET    B49  B1294      29                                                       
HET    B49  C1294      29                                                       
HET    B49  D1294      29                                                       
HETNAM     B49 N-[2-(DIETHYLAMINO)ETHYL]-5-[(Z)-(5-FLUORO-2-OXO-1,2-            
HETNAM   2 B49  DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-2,4-DIMETHYL-1H-             
HETNAM   3 B49  PYRROLE-3-CARBOXAMIDE                                           
HETSYN     B49 SUNITINIB                                                        
FORMUL   5  B49    4(C22 H27 F N4 O2)                                           
FORMUL   9  HOH   *283(H2 O)                                                    
HELIX    1   1 PRO A   12  LYS A   23  1                                  12    
HELIX    2   2 SER A   63  ALA A   85  1                                  23    
HELIX    3   3 GLU A  114  VAL A  123  1                                  10    
HELIX    4   4 SER A  126  ASN A  147  1                                  22    
HELIX    5   5 LYS A  155  GLU A  157  5                                   3    
HELIX    6   6 THR A  190  LEU A  194  5                                   5    
HELIX    7   7 ALA A  195  SER A  202  1                                   8    
HELIX    8   8 GLU A  213  GLY A  229  1                                  17    
HELIX    9   9 ARG A  237  GLY A  248  1                                  12    
HELIX   10  10 SER A  253  ASP A  258  1                                   6    
HELIX   11  11 SER A  261  LEU A  272  1                                  12    
HELIX   12  12 THR A  281  HIS A  288  1                                   8    
HELIX   13  13 PRO A  289  GLU A  292  5                                   4    
HELIX   14  14 PRO B   12  LYS B   23  1                                  12    
HELIX   15  15 SER B   63  ALA B   85  1                                  23    
HELIX   16  16 LEU B  115  VAL B  123  1                                   9    
HELIX   17  17 SER B  126  ASN B  147  1                                  22    
HELIX   18  18 LYS B  155  GLU B  157  5                                   3    
HELIX   19  19 THR B  190  LEU B  194  5                                   5    
HELIX   20  20 ALA B  195  ASP B  204  1                                  10    
HELIX   21  21 LYS B  212  GLY B  229  1                                  18    
HELIX   22  22 ARG B  237  GLY B  248  1                                  12    
HELIX   23  23 SER B  253  ASP B  258  1                                   6    
HELIX   24  24 SER B  261  LEU B  272  1                                  12    
HELIX   25  25 THR B  281  GLN B  287  1                                   7    
HELIX   26  26 HIS B  288  GLU B  292  5                                   5    
HELIX   27  27 PRO C   12  LYS C   23  1                                  12    
HELIX   28  28 SER C   63  ALA C   85  1                                  23    
HELIX   29  29 LEU C  115  VAL C  123  1                                   9    
HELIX   30  30 SER C  126  ASN C  147  1                                  22    
HELIX   31  31 LYS C  155  GLU C  157  5                                   3    
HELIX   32  32 THR C  190  LEU C  194  5                                   5    
HELIX   33  33 ALA C  195  ASP C  204  1                                  10    
HELIX   34  34 LYS C  212  GLY C  229  1                                  18    
HELIX   35  35 ARG C  237  GLU C  247  1                                  11    
HELIX   36  36 SER C  253  ASP C  258  1                                   6    
HELIX   37  37 SER C  261  LEU C  272  1                                  12    
HELIX   38  38 THR C  281  GLN C  287  1                                   7    
HELIX   39  39 HIS C  288  GLU C  292  5                                   5    
HELIX   40  40 PRO D   12  LYS D   23  1                                  12    
HELIX   41  41 SER D   63  ALA D   85  1                                  23    
HELIX   42  42 LEU D  115  VAL D  123  1                                   9    
HELIX   43  43 SER D  126  ASN D  147  1                                  22    
HELIX   44  44 LYS D  155  GLU D  157  5                                   3    
HELIX   45  45 THR D  190  LEU D  194  5                                   5    
HELIX   46  46 ALA D  195  ASP D  204  1                                  10    
HELIX   47  47 GLU D  213  GLY D  229  1                                  17    
HELIX   48  48 ARG D  237  GLY D  248  1                                  12    
HELIX   49  49 SER D  253  ASP D  258  1                                   6    
HELIX   50  50 SER D  261  LEU D  272  1                                  12    
HELIX   51  51 THR D  281  GLN D  287  1                                   7    
SHEET    1  AA 5 TYR A  24  ARG A  32  0                                        
SHEET    2  AA 5 SER A  36  HIS A  43 -1  O  VAL A  38   N  ILE A  30           
SHEET    3  AA 5 GLU A  49  GLU A  56 -1  O  PHE A  50   N  CYS A  41           
SHEET    4  AA 5 PHE A 102  PHE A 107 -1  O  MET A 103   N  MET A  55           
SHEET    5  AA 5 LEU A  93  GLU A  98 -1  N  ILE A  94   O  VAL A 106           
SHEET    1  AB 2 ILE A 149  VAL A 150  0                                        
SHEET    2  AB 2 CYS A 176  HIS A 177 -1  O  CYS A 176   N  VAL A 150           
SHEET    1  AC 2 ILE A 159  LEU A 161  0                                        
SHEET    2  AC 2 ILE A 167  LEU A 169 -1  O  ARG A 168   N  LEU A 160           
SHEET    1  BA 5 TYR B  24  ARG B  32  0                                        
SHEET    2  BA 5 SER B  36  HIS B  43 -1  O  VAL B  38   N  ILE B  30           
SHEET    3  BA 5 GLU B  49  GLU B  56 -1  O  PHE B  50   N  CYS B  41           
SHEET    4  BA 5 PHE B 102  PHE B 107 -1  O  MET B 103   N  MET B  55           
SHEET    5  BA 5 LEU B  93  GLU B  98 -1  N  ILE B  94   O  VAL B 106           
SHEET    1  BB 3 GLY B 113  GLU B 114  0                                        
SHEET    2  BB 3 ILE B 159  LEU B 161 -1  N  LEU B 161   O  GLY B 113           
SHEET    3  BB 3 ILE B 167  LEU B 169 -1  O  ARG B 168   N  LEU B 160           
SHEET    1  BC 2 ILE B 149  VAL B 150  0                                        
SHEET    2  BC 2 CYS B 176  HIS B 177 -1  O  CYS B 176   N  VAL B 150           
SHEET    1  CA 5 TYR C  24  ARG C  32  0                                        
SHEET    2  CA 5 SER C  36  HIS C  43 -1  O  VAL C  38   N  ILE C  30           
SHEET    3  CA 5 GLU C  49  GLU C  56 -1  O  PHE C  50   N  CYS C  41           
SHEET    4  CA 5 PHE C 102  PHE C 107 -1  O  MET C 103   N  MET C  55           
SHEET    5  CA 5 LEU C  93  GLU C  98 -1  N  ILE C  94   O  VAL C 106           
SHEET    1  CB 3 GLY C 113  GLU C 114  0                                        
SHEET    2  CB 3 ILE C 159  LEU C 161 -1  N  LEU C 161   O  GLY C 113           
SHEET    3  CB 3 ILE C 167  LEU C 169 -1  O  ARG C 168   N  LEU C 160           
SHEET    1  CC 2 ILE C 149  VAL C 150  0                                        
SHEET    2  CC 2 CYS C 176  HIS C 177 -1  O  CYS C 176   N  VAL C 150           
SHEET    1  DA 5 TYR D  24  ARG D  32  0                                        
SHEET    2  DA 5 SER D  36  HIS D  43 -1  O  VAL D  38   N  ILE D  30           
SHEET    3  DA 5 GLU D  49  GLU D  56 -1  O  PHE D  50   N  CYS D  41           
SHEET    4  DA 5 PHE D 102  ASP D 108 -1  O  MET D 103   N  MET D  55           
SHEET    5  DA 5 LEU D  93  GLU D  98 -1  N  ILE D  94   O  VAL D 106           
SHEET    1  DB 3 GLY D 113  GLU D 114  0                                        
SHEET    2  DB 3 ILE D 159  LEU D 161 -1  N  LEU D 161   O  GLY D 113           
SHEET    3  DB 3 ILE D 167  LEU D 169 -1  O  ARG D 168   N  LEU D 160           
SHEET    1  DC 2 ILE D 149  VAL D 150  0                                        
SHEET    2  DC 2 CYS D 176  HIS D 177 -1  O  CYS D 176   N  VAL D 150           
SITE     1 AC1 13 VAL A  29  ILE A  30  GLY A  31  ARG A  32                    
SITE     2 AC1 13 ALA A  51  PHE A 107  ASP A 108  MET A 110                    
SITE     3 AC1 13 ARG A 111  GLY A 113  LEU A 160  ASP A 171                    
SITE     4 AC1 13 HOH A2063                                                     
SITE     1 AC2 11 VAL B  29  ILE B  30  ALA B  51  ILE B  91                    
SITE     2 AC2 11 PHE B 107  ASP B 108  MET B 110  ARG B 111                    
SITE     3 AC2 11 GLY B 113  LEU B 160  HOH B2036                               
SITE     1 AC3 10 ILE C  30  ALA C  51  ILE C  91  PHE C 107                    
SITE     2 AC3 10 ASP C 108  MET C 110  ARG C 111  GLY C 113                    
SITE     3 AC3 10 ASP C 117  LEU C 160                                          
SITE     1 AC4 10 ILE D  30  ALA D  51  PHE D 107  ASP D 108                    
SITE     2 AC4 10 LEU D 109  MET D 110  ARG D 111  GLY D 113                    
SITE     3 AC4 10 LEU D 160  HOH D2028                                          
CRYST1   87.790   91.420  164.480  90.00  90.00  90.00 P 21 21 21   16          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.011391  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.010939  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.006080        0.00000                         
MTRIX1   1 -0.334400 -0.896600  0.290400        9.41390    1                    
MTRIX2   1 -0.817800  0.122900 -0.562200        5.16780    1                    
MTRIX3   1  0.468400 -0.425500 -0.774300       12.33360    1                    
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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