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Database: PDB
Entry: 3J96
LinkDB: 3J96
Original site: 3J96 
HEADER    HYDROLASE                               05-DEC-14   3J96              
TITLE     STRUCTURE OF 20S SUPERCOMPLEX DETERMINED BY SINGLE PARTICLE           
TITLE    2 CRYOELECTRON MICROSCOPY (STATE I)                                    
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: VESICLE-FUSING ATPASE;                                     
COMPND   3 CHAIN: A, B, C, D, E, F;                                             
COMPND   4 SYNONYM: N-ETHYLMALEIMIDE-SENSITIVE FUSION PROTEIN, NEM-SENSITIVE    
COMPND   5 FUSION PROTEIN, VESICULAR-FUSION PROTEIN NSF, N-ETHYLMALEIMIDE       
COMPND   6 SENSITIVE FACTOR;                                                    
COMPND   7 EC: 3.6.4.6;                                                         
COMPND   8 ENGINEERED: YES;                                                     
COMPND   9 MOL_ID: 2;                                                           
COMPND  10 MOLECULE: ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN;                      
COMPND  11 CHAIN: G, H, I, J;                                                   
COMPND  12 SYNONYM: SNAP-ALPHA, N-ETHYLMALEIMIDE-SENSITIVE FACTOR ATTACHMENT    
COMPND  13 PROTEIN ALPHA, ALPHA-SNAP;                                           
COMPND  14 ENGINEERED: YES;                                                     
COMPND  15 MOL_ID: 3;                                                           
COMPND  16 MOLECULE: VESICLE-ASSOCIATED MEMBRANE PROTEIN 2;                     
COMPND  17 CHAIN: K;                                                            
COMPND  18 FRAGMENT: UNP RESIDUES 28-89;                                        
COMPND  19 SYNONYM: VAMP-2, SYNAPTOBREVIN-2;                                    
COMPND  20 ENGINEERED: YES;                                                     
COMPND  21 MOL_ID: 4;                                                           
COMPND  22 MOLECULE: SYNTAXIN-1A;                                               
COMPND  23 CHAIN: L;                                                            
COMPND  24 FRAGMENT: UNP RESIDUES 191-256;                                      
COMPND  25 SYNONYM: NEURON-SPECIFIC ANTIGEN HPC-1, SYNAPTOTAGMIN-ASSOCIATED 35  
COMPND  26 KDA PROTEIN, P35A;                                                   
COMPND  27 ENGINEERED: YES;                                                     
COMPND  28 MOL_ID: 5;                                                           
COMPND  29 MOLECULE: SYNAPTOSOMAL-ASSOCIATED PROTEIN 25;                        
COMPND  30 CHAIN: M;                                                            
COMPND  31 SYNONYM: SNAP-25, SUPER PROTEIN, SUP, SYNAPTOSOMAL-ASSOCIATED 25 KDA 
COMPND  32 PROTEIN;                                                             
COMPND  33 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: CRICETULUS GRISEUS;                             
SOURCE   3 ORGANISM_COMMON: CHINESE HAMSTER;                                    
SOURCE   4 ORGANISM_TAXID: 10029;                                               
SOURCE   5 GENE: NSF;                                                           
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;                              
SOURCE  10 ORGANISM_COMMON: RAT;                                                
SOURCE  11 ORGANISM_TAXID: 10116;                                               
SOURCE  12 GENE: NAPA, SNAP, SNAPA;                                             
SOURCE  13 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;                              
SOURCE  17 ORGANISM_COMMON: RAT;                                                
SOURCE  18 ORGANISM_TAXID: 10116;                                               
SOURCE  19 GENE: VAMP2, SYB2;                                                   
SOURCE  20 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  21 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  22 MOL_ID: 4;                                                           
SOURCE  23 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;                              
SOURCE  24 ORGANISM_COMMON: RAT;                                                
SOURCE  25 ORGANISM_TAXID: 10116;                                               
SOURCE  26 GENE: STX1A, SAP;                                                    
SOURCE  27 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  28 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  29 MOL_ID: 5;                                                           
SOURCE  30 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;                              
SOURCE  31 ORGANISM_COMMON: RAT;                                                
SOURCE  32 ORGANISM_TAXID: 10116;                                               
SOURCE  33 GENE: SNAP25, SNAP;                                                  
SOURCE  34 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  35 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    VESICLE TRAFFICKING, HYDROLASE                                        
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    M.ZHAO,S.WU,Y.CHENG,A.T.BRUNGER                                       
REVDAT   3   18-JUL-18 3J96    1       REMARK                                   
REVDAT   2   11-FEB-15 3J96    1       JRNL                                     
REVDAT   1   28-JAN-15 3J96    0                                                
JRNL        AUTH   M.ZHAO,S.WU,Q.ZHOU,S.VIVONA,D.J.CIPRIANO,Y.CHENG,A.T.BRUNGER 
JRNL        TITL   MECHANISTIC INSIGHTS INTO THE RECYCLING MACHINE OF THE SNARE 
JRNL        TITL 2 COMPLEX.                                                     
JRNL        REF    NATURE                        V. 518    61 2015              
JRNL        REFN                   ISSN 0028-0836                               
JRNL        PMID   25581794                                                     
JRNL        DOI    10.1038/NATURE14148                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    7.60 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : PHENIX, UCSF CHIMERA, RELION              
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : 1NSF                                
REMARK   3   REFINEMENT SPACE             : RECIPROCAL                          
REMARK   3   REFINEMENT PROTOCOL          : FLEXIBLE FIT                        
REMARK   3   REFINEMENT TARGET            : R-FACTOR                            
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : REFINEMENT PROTOCOL--FLEXIBLE DETAILS--D2        
REMARK   3  DOMAIN OF NSF WAS FROM CRYSTAL STRUCTURE 1NSF. D1 DOMAIN OF NSF     
REMARK   3  WAS FROM RELATED ENTRY EMD-6204. N DOMAIN OF NSF WAS FROM           
REMARK   3  CRYSTAL STRUCTURE 1QCS. ASNAP WAS A HOMOLOGY MODEL. SNARE           
REMARK   3  COMPLEX WAS FROM CRYSTAL STRUCTURE 1N7S.                            
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : 2.431                          
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 7.600                          
REMARK   3   NUMBER OF PARTICLES               : 29717                          
REMARK   3   CTF CORRECTION METHOD             : NULL                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: (SINGLE PARTICLE DETAILS: 3D CLASSIFICATION,          
REMARK   3  REFINEMENT, AND RECONSTRUCTION WERE PERFORMED USING RELION)         
REMARK   3  (SINGLE PARTICLE--APPLIED SYMMETRY: C1)                             
REMARK   4                                                                      
REMARK   4 3J96 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 10-DEC-14.                  
REMARK 100 THE DEPOSITION ID IS D_1000160408.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : VITREOUS ICE (CRYO EM)            
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : 20S SUPERCOMPLEX CONSISTING OF    
REMARK 245                                    TRUNCATED NEURONAL SNARE          
REMARK 245                                    COMPLEX, ALPHA-SNAP, AND N-       
REMARK 245                                    ETHYLMALEIMIDE SENSITIVE FACTOR   
REMARK 245                                    (NSF); N-ETHYLMALEIMIDE           
REMARK 245                                    SENSITIVE FACTOR; ALPHA SOLUBLE   
REMARK 245                                    NSF ATTACHMENT PROTEIN;           
REMARK 245                                    SYNTAXIN-1A; SYNAPTOBREVIN-2;     
REMARK 245                                    SYNAPTOSOMAL-ASSOCIATED PROTEIN   
REMARK 245                                    25                                
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 15.00                             
REMARK 245   SAMPLE SUPPORT DETAILS         : HOLEY CARBON ON TOP OF 400 MESH   
REMARK 245                                    COPPER GRID                       
REMARK 245   SAMPLE VITRIFICATION DETAILS   : BLOT FOR 3.5 SECONDS BEFORE       
REMARK 245                                    PLUNGING INTO LIQUID ETHANE       
REMARK 245                                    (FEI VITROBOT MARK I).            
REMARK 245   SAMPLE BUFFER                  : 50 MM TRIS-CL, 150 MM NACL, 1     
REMARK 245                                    MM AMPPNP, 1 MM EDTA, 1 MM DTT,   
REMARK 245                                    0.05% V/V NONIDENT P-40           
REMARK 245   PH                             : 8.00                              
REMARK 245   SAMPLE DETAILS                 : ONE HEXAMER OF NSF + FOUR ALPHA   
REMARK 245  -SNAP MOLECULES + ONE SNARE COMPLEX                                 
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : 28-JAN-14                      
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI POLARA 300                 
REMARK 245   DETECTOR TYPE                     : GATAN K2 (4K X 4K)             
REMARK 245   MINIMUM DEFOCUS (NM)              : -1800.00                       
REMARK 245   MAXIMUM DEFOCUS (NM)              : -2800.00                       
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.30                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 44.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : 31000                          
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIDECAMERIC                      
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: K, L, M                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     GLY A    -2                                                      
REMARK 465     ALA A    -1                                                      
REMARK 465     HIS A     0                                                      
REMARK 465     ASP A   156                                                      
REMARK 465     PRO A   157                                                      
REMARK 465     SER A   158                                                      
REMARK 465     ILE A   159                                                      
REMARK 465     LEU A   160                                                      
REMARK 465     LYS A   161                                                      
REMARK 465     GLY A   162                                                      
REMARK 465     GLU A   163                                                      
REMARK 465     PRO A   164                                                      
REMARK 465     ALA A   165                                                      
REMARK 465     SER A   166                                                      
REMARK 465     GLY A   167                                                      
REMARK 465     LYS A   168                                                      
REMARK 465     LYS A   202                                                      
REMARK 465     GLU A   203                                                      
REMARK 465     ASN A   204                                                      
REMARK 465     ARG A   205                                                      
REMARK 465     GLN A   206                                                      
REMARK 465     SER A   207                                                      
REMARK 465     ILE A   208                                                      
REMARK 465     ILE A   209                                                      
REMARK 465     ASN A   210                                                      
REMARK 465     PRO A   211                                                      
REMARK 465     ASP A   212                                                      
REMARK 465     TRP A   213                                                      
REMARK 465     ASN A   214                                                      
REMARK 465     LYS A   335                                                      
REMARK 465     GLN A   336                                                      
REMARK 465     ARG A   337                                                      
REMARK 465     GLY A   338                                                      
REMARK 465     SER A   339                                                      
REMARK 465     MET A   340                                                      
REMARK 465     ALA A   341                                                      
REMARK 465     GLY A   342                                                      
REMARK 465     SER A   343                                                      
REMARK 465     THR A   344                                                      
REMARK 465     GLY A   345                                                      
REMARK 465     VAL A   346                                                      
REMARK 465     LYS A   458                                                      
REMARK 465     ALA A   459                                                      
REMARK 465     SER A   460                                                      
REMARK 465     THR A   461                                                      
REMARK 465     LYS A   462                                                      
REMARK 465     VAL A   463                                                      
REMARK 465     GLU A   464                                                      
REMARK 465     VAL A   465                                                      
REMARK 465     ASP A   466                                                      
REMARK 465     MET A   467                                                      
REMARK 465     GLU A   468                                                      
REMARK 465     LYS A   469                                                      
REMARK 465     ALA A   470                                                      
REMARK 465     GLU A   471                                                      
REMARK 465     SER A   472                                                      
REMARK 465     LEU A   473                                                      
REMARK 465     GLN A   474                                                      
REMARK 465     VAL A   475                                                      
REMARK 465     THR A   476                                                      
REMARK 465     ARG A   477                                                      
REMARK 465     GLY A   478                                                      
REMARK 465     ALA A   738                                                      
REMARK 465     SER A   739                                                      
REMARK 465     PRO A   740                                                      
REMARK 465     LEU A   741                                                      
REMARK 465     ASP A   742                                                      
REMARK 465     PHE A   743                                                      
REMARK 465     ASP A   744                                                      
REMARK 465     GLY B    -2                                                      
REMARK 465     ALA B    -1                                                      
REMARK 465     HIS B     0                                                      
REMARK 465     ASP B   156                                                      
REMARK 465     PRO B   157                                                      
REMARK 465     SER B   158                                                      
REMARK 465     ILE B   159                                                      
REMARK 465     LEU B   160                                                      
REMARK 465     LYS B   161                                                      
REMARK 465     GLY B   162                                                      
REMARK 465     GLU B   163                                                      
REMARK 465     PRO B   164                                                      
REMARK 465     ALA B   165                                                      
REMARK 465     SER B   166                                                      
REMARK 465     GLY B   167                                                      
REMARK 465     LYS B   168                                                      
REMARK 465     LYS B   202                                                      
REMARK 465     GLU B   203                                                      
REMARK 465     ASN B   204                                                      
REMARK 465     ARG B   205                                                      
REMARK 465     GLN B   206                                                      
REMARK 465     SER B   207                                                      
REMARK 465     ILE B   208                                                      
REMARK 465     ILE B   209                                                      
REMARK 465     ASN B   210                                                      
REMARK 465     PRO B   211                                                      
REMARK 465     ASP B   212                                                      
REMARK 465     TRP B   213                                                      
REMARK 465     ASN B   214                                                      
REMARK 465     PHE B   215                                                      
REMARK 465     GLU B   216                                                      
REMARK 465     ASP B   331                                                      
REMARK 465     ALA B   332                                                      
REMARK 465     ILE B   333                                                      
REMARK 465     CYS B   334                                                      
REMARK 465     LYS B   335                                                      
REMARK 465     GLN B   336                                                      
REMARK 465     ARG B   337                                                      
REMARK 465     GLY B   338                                                      
REMARK 465     SER B   339                                                      
REMARK 465     MET B   340                                                      
REMARK 465     ALA B   341                                                      
REMARK 465     GLY B   342                                                      
REMARK 465     SER B   343                                                      
REMARK 465     THR B   344                                                      
REMARK 465     GLY B   345                                                      
REMARK 465     VAL B   346                                                      
REMARK 465     LYS B   458                                                      
REMARK 465     ALA B   459                                                      
REMARK 465     SER B   460                                                      
REMARK 465     THR B   461                                                      
REMARK 465     LYS B   462                                                      
REMARK 465     VAL B   463                                                      
REMARK 465     GLU B   464                                                      
REMARK 465     VAL B   465                                                      
REMARK 465     ASP B   466                                                      
REMARK 465     MET B   467                                                      
REMARK 465     GLU B   468                                                      
REMARK 465     LYS B   469                                                      
REMARK 465     ALA B   470                                                      
REMARK 465     GLU B   471                                                      
REMARK 465     SER B   472                                                      
REMARK 465     LEU B   473                                                      
REMARK 465     GLN B   474                                                      
REMARK 465     VAL B   475                                                      
REMARK 465     THR B   476                                                      
REMARK 465     ARG B   477                                                      
REMARK 465     GLY B   478                                                      
REMARK 465     ALA B   738                                                      
REMARK 465     SER B   739                                                      
REMARK 465     PRO B   740                                                      
REMARK 465     LEU B   741                                                      
REMARK 465     ASP B   742                                                      
REMARK 465     PHE B   743                                                      
REMARK 465     ASP B   744                                                      
REMARK 465     GLY C    -2                                                      
REMARK 465     ALA C    -1                                                      
REMARK 465     HIS C     0                                                      
REMARK 465     ASP C   156                                                      
REMARK 465     PRO C   157                                                      
REMARK 465     SER C   158                                                      
REMARK 465     ILE C   159                                                      
REMARK 465     LEU C   160                                                      
REMARK 465     LYS C   161                                                      
REMARK 465     GLY C   162                                                      
REMARK 465     GLU C   163                                                      
REMARK 465     PRO C   164                                                      
REMARK 465     ALA C   165                                                      
REMARK 465     SER C   166                                                      
REMARK 465     GLY C   167                                                      
REMARK 465     LYS C   168                                                      
REMARK 465     LYS C   202                                                      
REMARK 465     GLU C   203                                                      
REMARK 465     ASN C   204                                                      
REMARK 465     ARG C   205                                                      
REMARK 465     GLN C   206                                                      
REMARK 465     SER C   207                                                      
REMARK 465     ILE C   208                                                      
REMARK 465     ILE C   209                                                      
REMARK 465     ASN C   210                                                      
REMARK 465     PRO C   211                                                      
REMARK 465     ASP C   212                                                      
REMARK 465     TRP C   213                                                      
REMARK 465     ASN C   214                                                      
REMARK 465     PHE C   215                                                      
REMARK 465     GLU C   216                                                      
REMARK 465     LYS C   335                                                      
REMARK 465     GLN C   336                                                      
REMARK 465     ARG C   337                                                      
REMARK 465     GLY C   338                                                      
REMARK 465     SER C   339                                                      
REMARK 465     MET C   340                                                      
REMARK 465     ALA C   341                                                      
REMARK 465     GLY C   342                                                      
REMARK 465     SER C   343                                                      
REMARK 465     THR C   344                                                      
REMARK 465     GLY C   345                                                      
REMARK 465     VAL C   346                                                      
REMARK 465     LYS C   458                                                      
REMARK 465     ALA C   459                                                      
REMARK 465     SER C   460                                                      
REMARK 465     THR C   461                                                      
REMARK 465     LYS C   462                                                      
REMARK 465     VAL C   463                                                      
REMARK 465     GLU C   464                                                      
REMARK 465     VAL C   465                                                      
REMARK 465     ASP C   466                                                      
REMARK 465     MET C   467                                                      
REMARK 465     GLU C   468                                                      
REMARK 465     LYS C   469                                                      
REMARK 465     ALA C   470                                                      
REMARK 465     GLU C   471                                                      
REMARK 465     SER C   472                                                      
REMARK 465     LEU C   473                                                      
REMARK 465     GLN C   474                                                      
REMARK 465     VAL C   475                                                      
REMARK 465     THR C   476                                                      
REMARK 465     ARG C   477                                                      
REMARK 465     GLY C   478                                                      
REMARK 465     ALA C   738                                                      
REMARK 465     SER C   739                                                      
REMARK 465     PRO C   740                                                      
REMARK 465     LEU C   741                                                      
REMARK 465     ASP C   742                                                      
REMARK 465     PHE C   743                                                      
REMARK 465     ASP C   744                                                      
REMARK 465     GLY D    -2                                                      
REMARK 465     ALA D    -1                                                      
REMARK 465     HIS D     0                                                      
REMARK 465     ASP D   156                                                      
REMARK 465     PRO D   157                                                      
REMARK 465     SER D   158                                                      
REMARK 465     ILE D   159                                                      
REMARK 465     LEU D   160                                                      
REMARK 465     LYS D   161                                                      
REMARK 465     GLY D   162                                                      
REMARK 465     GLU D   163                                                      
REMARK 465     PRO D   164                                                      
REMARK 465     ALA D   165                                                      
REMARK 465     SER D   166                                                      
REMARK 465     GLY D   167                                                      
REMARK 465     LYS D   168                                                      
REMARK 465     LYS D   202                                                      
REMARK 465     GLU D   203                                                      
REMARK 465     ASN D   204                                                      
REMARK 465     ARG D   205                                                      
REMARK 465     GLN D   206                                                      
REMARK 465     SER D   207                                                      
REMARK 465     ILE D   208                                                      
REMARK 465     ILE D   209                                                      
REMARK 465     ASN D   210                                                      
REMARK 465     PRO D   211                                                      
REMARK 465     ASP D   212                                                      
REMARK 465     TRP D   213                                                      
REMARK 465     ASN D   214                                                      
REMARK 465     PHE D   215                                                      
REMARK 465     GLU D   216                                                      
REMARK 465     CYS D   334                                                      
REMARK 465     LYS D   335                                                      
REMARK 465     GLN D   336                                                      
REMARK 465     ARG D   337                                                      
REMARK 465     GLY D   338                                                      
REMARK 465     SER D   339                                                      
REMARK 465     MET D   340                                                      
REMARK 465     ALA D   341                                                      
REMARK 465     GLY D   342                                                      
REMARK 465     SER D   343                                                      
REMARK 465     THR D   344                                                      
REMARK 465     GLY D   345                                                      
REMARK 465     VAL D   346                                                      
REMARK 465     HIS D   347                                                      
REMARK 465     LYS D   458                                                      
REMARK 465     ALA D   459                                                      
REMARK 465     SER D   460                                                      
REMARK 465     THR D   461                                                      
REMARK 465     LYS D   462                                                      
REMARK 465     VAL D   463                                                      
REMARK 465     GLU D   464                                                      
REMARK 465     VAL D   465                                                      
REMARK 465     ASP D   466                                                      
REMARK 465     MET D   467                                                      
REMARK 465     GLU D   468                                                      
REMARK 465     LYS D   469                                                      
REMARK 465     ALA D   470                                                      
REMARK 465     GLU D   471                                                      
REMARK 465     SER D   472                                                      
REMARK 465     LEU D   473                                                      
REMARK 465     GLN D   474                                                      
REMARK 465     VAL D   475                                                      
REMARK 465     THR D   476                                                      
REMARK 465     ARG D   477                                                      
REMARK 465     GLY D   478                                                      
REMARK 465     ASP D   479                                                      
REMARK 465     ALA D   738                                                      
REMARK 465     SER D   739                                                      
REMARK 465     PRO D   740                                                      
REMARK 465     LEU D   741                                                      
REMARK 465     ASP D   742                                                      
REMARK 465     PHE D   743                                                      
REMARK 465     ASP D   744                                                      
REMARK 465     GLY E    -2                                                      
REMARK 465     ALA E    -1                                                      
REMARK 465     HIS E     0                                                      
REMARK 465     ASP E   156                                                      
REMARK 465     PRO E   157                                                      
REMARK 465     SER E   158                                                      
REMARK 465     ILE E   159                                                      
REMARK 465     LEU E   160                                                      
REMARK 465     LYS E   161                                                      
REMARK 465     GLY E   162                                                      
REMARK 465     GLU E   163                                                      
REMARK 465     PRO E   164                                                      
REMARK 465     ALA E   165                                                      
REMARK 465     SER E   166                                                      
REMARK 465     GLY E   167                                                      
REMARK 465     LYS E   168                                                      
REMARK 465     LYS E   202                                                      
REMARK 465     GLU E   203                                                      
REMARK 465     ASN E   204                                                      
REMARK 465     ARG E   205                                                      
REMARK 465     GLN E   206                                                      
REMARK 465     SER E   207                                                      
REMARK 465     ILE E   208                                                      
REMARK 465     ILE E   209                                                      
REMARK 465     ASN E   210                                                      
REMARK 465     PRO E   211                                                      
REMARK 465     ASP E   212                                                      
REMARK 465     TRP E   213                                                      
REMARK 465     ASN E   214                                                      
REMARK 465     PHE E   215                                                      
REMARK 465     GLU E   216                                                      
REMARK 465     ASP E   331                                                      
REMARK 465     ALA E   332                                                      
REMARK 465     ILE E   333                                                      
REMARK 465     CYS E   334                                                      
REMARK 465     LYS E   335                                                      
REMARK 465     GLN E   336                                                      
REMARK 465     ARG E   337                                                      
REMARK 465     GLY E   338                                                      
REMARK 465     SER E   339                                                      
REMARK 465     MET E   340                                                      
REMARK 465     ALA E   341                                                      
REMARK 465     GLY E   342                                                      
REMARK 465     SER E   343                                                      
REMARK 465     THR E   344                                                      
REMARK 465     GLY E   345                                                      
REMARK 465     VAL E   346                                                      
REMARK 465     LYS E   458                                                      
REMARK 465     ALA E   459                                                      
REMARK 465     SER E   460                                                      
REMARK 465     THR E   461                                                      
REMARK 465     LYS E   462                                                      
REMARK 465     VAL E   463                                                      
REMARK 465     GLU E   464                                                      
REMARK 465     VAL E   465                                                      
REMARK 465     ASP E   466                                                      
REMARK 465     MET E   467                                                      
REMARK 465     GLU E   468                                                      
REMARK 465     LYS E   469                                                      
REMARK 465     ALA E   470                                                      
REMARK 465     GLU E   471                                                      
REMARK 465     SER E   472                                                      
REMARK 465     LEU E   473                                                      
REMARK 465     GLN E   474                                                      
REMARK 465     VAL E   475                                                      
REMARK 465     THR E   476                                                      
REMARK 465     ARG E   477                                                      
REMARK 465     GLY E   478                                                      
REMARK 465     ASN E   495                                                      
REMARK 465     GLN E   496                                                      
REMARK 465     ALA E   738                                                      
REMARK 465     SER E   739                                                      
REMARK 465     PRO E   740                                                      
REMARK 465     LEU E   741                                                      
REMARK 465     ASP E   742                                                      
REMARK 465     PHE E   743                                                      
REMARK 465     ASP E   744                                                      
REMARK 465     GLY F    -2                                                      
REMARK 465     ALA F    -1                                                      
REMARK 465     HIS F     0                                                      
REMARK 465     ASP F   156                                                      
REMARK 465     PRO F   157                                                      
REMARK 465     SER F   158                                                      
REMARK 465     ILE F   159                                                      
REMARK 465     LEU F   160                                                      
REMARK 465     LYS F   161                                                      
REMARK 465     GLY F   162                                                      
REMARK 465     GLU F   163                                                      
REMARK 465     PRO F   164                                                      
REMARK 465     ALA F   165                                                      
REMARK 465     SER F   166                                                      
REMARK 465     GLY F   167                                                      
REMARK 465     LYS F   168                                                      
REMARK 465     LYS F   202                                                      
REMARK 465     GLU F   203                                                      
REMARK 465     ASN F   204                                                      
REMARK 465     ARG F   205                                                      
REMARK 465     GLN F   206                                                      
REMARK 465     SER F   207                                                      
REMARK 465     ILE F   208                                                      
REMARK 465     ILE F   209                                                      
REMARK 465     ASN F   210                                                      
REMARK 465     PRO F   211                                                      
REMARK 465     ASP F   212                                                      
REMARK 465     TRP F   213                                                      
REMARK 465     ASN F   214                                                      
REMARK 465     PHE F   215                                                      
REMARK 465     GLU F   216                                                      
REMARK 465     ASP F   331                                                      
REMARK 465     ALA F   332                                                      
REMARK 465     ILE F   333                                                      
REMARK 465     CYS F   334                                                      
REMARK 465     LYS F   335                                                      
REMARK 465     GLN F   336                                                      
REMARK 465     ARG F   337                                                      
REMARK 465     GLY F   338                                                      
REMARK 465     SER F   339                                                      
REMARK 465     MET F   340                                                      
REMARK 465     ALA F   341                                                      
REMARK 465     GLY F   342                                                      
REMARK 465     SER F   343                                                      
REMARK 465     THR F   344                                                      
REMARK 465     GLY F   345                                                      
REMARK 465     VAL F   346                                                      
REMARK 465     LYS F   458                                                      
REMARK 465     ALA F   459                                                      
REMARK 465     SER F   460                                                      
REMARK 465     THR F   461                                                      
REMARK 465     LYS F   462                                                      
REMARK 465     VAL F   463                                                      
REMARK 465     GLU F   464                                                      
REMARK 465     VAL F   465                                                      
REMARK 465     ASP F   466                                                      
REMARK 465     MET F   467                                                      
REMARK 465     GLU F   468                                                      
REMARK 465     LYS F   469                                                      
REMARK 465     ALA F   470                                                      
REMARK 465     GLU F   471                                                      
REMARK 465     SER F   472                                                      
REMARK 465     LEU F   473                                                      
REMARK 465     GLN F   474                                                      
REMARK 465     VAL F   475                                                      
REMARK 465     THR F   476                                                      
REMARK 465     ARG F   477                                                      
REMARK 465     GLY F   478                                                      
REMARK 465     ASP F   479                                                      
REMARK 465     PHE F   480                                                      
REMARK 465     LEU F   481                                                      
REMARK 465     ALA F   482                                                      
REMARK 465     SER F   483                                                      
REMARK 465     LEU F   484                                                      
REMARK 465     GLU F   485                                                      
REMARK 465     ASN F   486                                                      
REMARK 465     ASP F   487                                                      
REMARK 465     ILE F   488                                                      
REMARK 465     LYS F   489                                                      
REMARK 465     PRO F   490                                                      
REMARK 465     ALA F   491                                                      
REMARK 465     PHE F   492                                                      
REMARK 465     GLY F   493                                                      
REMARK 465     THR F   494                                                      
REMARK 465     ASN F   495                                                      
REMARK 465     GLN F   496                                                      
REMARK 465     ALA F   738                                                      
REMARK 465     SER F   739                                                      
REMARK 465     PRO F   740                                                      
REMARK 465     LEU F   741                                                      
REMARK 465     ASP F   742                                                      
REMARK 465     PHE F   743                                                      
REMARK 465     ASP F   744                                                      
REMARK 465     GLY G    -1                                                      
REMARK 465     SER G     0                                                      
REMARK 465     MET G     1                                                      
REMARK 465     ASP G     2                                                      
REMARK 465     THR G     3                                                      
REMARK 465     SER G     4                                                      
REMARK 465     GLY G     5                                                      
REMARK 465     LYS G     6                                                      
REMARK 465     GLN G     7                                                      
REMARK 465     LEU G   294                                                      
REMARK 465     ARG G   295                                                      
REMARK 465     GLY H    -1                                                      
REMARK 465     SER H     0                                                      
REMARK 465     MET H     1                                                      
REMARK 465     ASP H     2                                                      
REMARK 465     THR H     3                                                      
REMARK 465     SER H     4                                                      
REMARK 465     GLY H     5                                                      
REMARK 465     LYS H     6                                                      
REMARK 465     GLN H     7                                                      
REMARK 465     LEU H   294                                                      
REMARK 465     ARG H   295                                                      
REMARK 465     GLY I    -1                                                      
REMARK 465     SER I     0                                                      
REMARK 465     MET I     1                                                      
REMARK 465     ASP I     2                                                      
REMARK 465     THR I     3                                                      
REMARK 465     SER I     4                                                      
REMARK 465     GLY I     5                                                      
REMARK 465     LYS I     6                                                      
REMARK 465     GLN I     7                                                      
REMARK 465     LEU I   294                                                      
REMARK 465     ARG I   295                                                      
REMARK 465     GLY J    -1                                                      
REMARK 465     SER J     0                                                      
REMARK 465     MET J     1                                                      
REMARK 465     ASP J     2                                                      
REMARK 465     THR J     3                                                      
REMARK 465     SER J     4                                                      
REMARK 465     GLY J     5                                                      
REMARK 465     LYS J     6                                                      
REMARK 465     GLN J     7                                                      
REMARK 465     LEU J   294                                                      
REMARK 465     ARG J   295                                                      
REMARK 465     GLY K    27                                                      
REMARK 465     SER K    28                                                      
REMARK 465     MET L   190                                                      
REMARK 465     PHE M    84                                                      
REMARK 465     CYS M    85                                                      
REMARK 465     GLY M    86                                                      
REMARK 465     LEU M    87                                                      
REMARK 465     CYS M    88                                                      
REMARK 465     VAL M    89                                                      
REMARK 465     CYS M    90                                                      
REMARK 465     PRO M    91                                                      
REMARK 465     CYS M    92                                                      
REMARK 465     ASN M    93                                                      
REMARK 465     LYS M    94                                                      
REMARK 465     LEU M    95                                                      
REMARK 465     LYS M    96                                                      
REMARK 465     SER M    97                                                      
REMARK 465     SER M    98                                                      
REMARK 465     ASP M    99                                                      
REMARK 465     ALA M   100                                                      
REMARK 465     TYR M   101                                                      
REMARK 465     LYS M   102                                                      
REMARK 465     LYS M   103                                                      
REMARK 465     ALA M   104                                                      
REMARK 465     TRP M   105                                                      
REMARK 465     GLY M   106                                                      
REMARK 465     ASN M   107                                                      
REMARK 465     ASN M   108                                                      
REMARK 465     GLN M   109                                                      
REMARK 465     ASP M   110                                                      
REMARK 465     GLY M   111                                                      
REMARK 465     VAL M   112                                                      
REMARK 465     VAL M   113                                                      
REMARK 465     ALA M   114                                                      
REMARK 465     SER M   115                                                      
REMARK 465     GLN M   116                                                      
REMARK 465     PRO M   117                                                      
REMARK 465     ALA M   118                                                      
REMARK 465     ARG M   119                                                      
REMARK 465     VAL M   120                                                      
REMARK 465     VAL M   121                                                      
REMARK 465     ASP M   122                                                      
REMARK 465     GLU M   123                                                      
REMARK 465     ARG M   124                                                      
REMARK 465     GLU M   125                                                      
REMARK 465     GLN M   126                                                      
REMARK 465     MET M   127                                                      
REMARK 465     ALA M   128                                                      
REMARK 465     ILE M   129                                                      
REMARK 465     SER M   130                                                      
REMARK 465     GLY M   131                                                      
REMARK 465     GLY M   132                                                      
REMARK 465     PHE M   133                                                      
REMARK 465     ILE M   134                                                      
REMARK 465     ARG M   135                                                      
REMARK 465     ARG M   136                                                      
REMARK 465     VAL M   137                                                      
REMARK 465     THR M   138                                                      
REMARK 465     ASN M   139                                                      
REMARK 465     ASP M   140                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     PHE A 215    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU A 216    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 217    CG   CD   CE   NZ                                   
REMARK 470     MET A 218    CG   SD   CE                                        
REMARK 470     ARG A 232    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 238    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN A 247    CG   CD   OE1  NE2                                  
REMARK 470     MET A 248    CG   SD   CE                                        
REMARK 470     LYS A 251    CG   CD   CE   NZ                                   
REMARK 470     LYS A 254    CG   CD   CE   NZ                                   
REMARK 470     LYS A 266    CG   CD   CE   NZ                                   
REMARK 470     LYS A 275    CG   CD   CE   NZ                                   
REMARK 470     MET A 276    CG   SD   CE                                        
REMARK 470     LEU A 277    CG   CD1  CD2                                       
REMARK 470     ASN A 278    CG   OD1  ND2                                       
REMARK 470     ARG A 280    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A 281    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 283    CG   CD   CE   NZ                                   
REMARK 470     GLU A 289    CG   CD   OE1  OE2                                  
REMARK 470     ILE A 290    CG1  CG2  CD1                                       
REMARK 470     LEU A 291    CG   CD1  CD2                                       
REMARK 470     ASN A 292    CG   OD1  ND2                                       
REMARK 470     LYS A 293    CG   CD   CE   NZ                                   
REMARK 470     GLU A 297    CG   CD   OE1  OE2                                  
REMARK 470     SER A 298    OG                                                  
REMARK 470     ILE A 302    CG1  CG2  CD1                                       
REMARK 470     GLU A 312    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 314    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A 329    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 331    CG   OD1  OD2                                       
REMARK 470     ILE A 333    CG1  CG2  CD1                                       
REMARK 470     CYS A 334    SG                                                  
REMARK 470     HIS A 347    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASP A 348    CG   OD1  OD2                                       
REMARK 470     ASP A 359    CG   OD1  OD2                                       
REMARK 470     VAL A 361    CG1  CG2                                            
REMARK 470     GLU A 362    CG   CD   OE1  OE2                                  
REMARK 470     GLN A 363    CG   CD   OE1  NE2                                  
REMARK 470     LEU A 364    CG   CD1  CD2                                       
REMARK 470     ASN A 366    CG   OD1  ND2                                       
REMARK 470     MET A 372    CG   SD   CE                                        
REMARK 470     GLU A 390    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 392    CG   CD   CE   NZ                                   
REMARK 470     MET A 393    CG   SD   CE                                        
REMARK 470     GLU A 394    CG   CD   OE1  OE2                                  
REMARK 470     LEU A 397    CG   CD1  CD2                                       
REMARK 470     ARG A 403    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 415    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 434    CG   CD   CE   NZ                                   
REMARK 470     ASN A 435    CG   OD1  ND2                                       
REMARK 470     ASP A 479    CG   OD1  OD2                                       
REMARK 470     PHE A 480    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU A 481    CG   CD1  CD2                                       
REMARK 470     SER A 483    OG                                                  
REMARK 470     LEU A 484    CG   CD1  CD2                                       
REMARK 470     GLU A 485    CG   CD   OE1  OE2                                  
REMARK 470     ASN A 486    CG   OD1  ND2                                       
REMARK 470     ASP A 487    CG   OD1  OD2                                       
REMARK 470     ILE A 488    CG1  CG2  CD1                                       
REMARK 470     LYS A 489    CG   CD   CE   NZ                                   
REMARK 470     PHE A 492    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     THR A 494    OG1  CG2                                            
REMARK 470     ASN A 495    CG   OD1  ND2                                       
REMARK 470     GLN A 496    CG   CD   OE1  NE2                                  
REMARK 470     ASN A 505    CG   OD1  ND2                                       
REMARK 470     PHE A 562    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP A 603    CG   OD1  OD2                                       
REMARK 470     LYS B 217    CG   CD   CE   NZ                                   
REMARK 470     MET B 218    CG   SD   CE                                        
REMARK 470     ARG B 232    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B 238    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN B 247    CG   CD   OE1  NE2                                  
REMARK 470     MET B 248    CG   SD   CE                                        
REMARK 470     LYS B 251    CG   CD   CE   NZ                                   
REMARK 470     LYS B 254    CG   CD   CE   NZ                                   
REMARK 470     LYS B 275    CG   CD   CE   NZ                                   
REMARK 470     MET B 276    CG   SD   CE                                        
REMARK 470     LEU B 277    CG   CD1  CD2                                       
REMARK 470     ASN B 278    CG   OD1  ND2                                       
REMARK 470     ARG B 280    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU B 281    CG   CD   OE1  OE2                                  
REMARK 470     LYS B 283    CG   CD   CE   NZ                                   
REMARK 470     GLU B 289    CG   CD   OE1  OE2                                  
REMARK 470     ILE B 290    CG1  CG2  CD1                                       
REMARK 470     LEU B 291    CG   CD1  CD2                                       
REMARK 470     ASN B 292    CG   OD1  ND2                                       
REMARK 470     LYS B 293    CG   CD   CE   NZ                                   
REMARK 470     GLU B 297    CG   CD   OE1  OE2                                  
REMARK 470     SER B 298    OG                                                  
REMARK 470     ILE B 302    CG1  CG2  CD1                                       
REMARK 470     GLU B 329    CG   CD   OE1  OE2                                  
REMARK 470     HIS B 347    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASP B 348    CG   OD1  OD2                                       
REMARK 470     ASP B 359    CG   OD1  OD2                                       
REMARK 470     VAL B 361    CG1  CG2                                            
REMARK 470     GLU B 362    CG   CD   OE1  OE2                                  
REMARK 470     GLN B 363    CG   CD   OE1  NE2                                  
REMARK 470     LEU B 364    CG   CD1  CD2                                       
REMARK 470     ASN B 366    CG   OD1  ND2                                       
REMARK 470     GLU B 390    CG   CD   OE1  OE2                                  
REMARK 470     LYS B 392    CG   CD   CE   NZ                                   
REMARK 470     MET B 393    CG   SD   CE                                        
REMARK 470     GLU B 394    CG   CD   OE1  OE2                                  
REMARK 470     ARG B 403    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B 415    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS B 434    CG   CD   CE   NZ                                   
REMARK 470     ASN B 435    CG   OD1  ND2                                       
REMARK 470     ARG B 446    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP B 479    CG   OD1  OD2                                       
REMARK 470     PHE B 480    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU B 481    CG   CD1  CD2                                       
REMARK 470     SER B 483    OG                                                  
REMARK 470     LEU B 484    CG   CD1  CD2                                       
REMARK 470     GLU B 485    CG   CD   OE1  OE2                                  
REMARK 470     ASN B 486    CG   OD1  ND2                                       
REMARK 470     ASP B 487    CG   OD1  OD2                                       
REMARK 470     ILE B 488    CG1  CG2  CD1                                       
REMARK 470     LYS B 489    CG   CD   CE   NZ                                   
REMARK 470     PHE B 492    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     THR B 494    OG1  CG2                                            
REMARK 470     ASN B 495    CG   OD1  ND2                                       
REMARK 470     GLN B 496    CG   CD   OE1  NE2                                  
REMARK 470     TYR B 499    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS C 217    CG   CD   CE   NZ                                   
REMARK 470     MET C 218    CG   SD   CE                                        
REMARK 470     ARG C 232    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG C 238    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN C 247    CG   CD   OE1  NE2                                  
REMARK 470     MET C 248    CG   SD   CE                                        
REMARK 470     LYS C 251    CG   CD   CE   NZ                                   
REMARK 470     LYS C 254    CG   CD   CE   NZ                                   
REMARK 470     LYS C 275    CG   CD   CE   NZ                                   
REMARK 470     MET C 276    CG   SD   CE                                        
REMARK 470     LEU C 277    CG   CD1  CD2                                       
REMARK 470     ASN C 278    CG   OD1  ND2                                       
REMARK 470     ARG C 280    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 281    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 283    CG   CD   CE   NZ                                   
REMARK 470     GLU C 289    CG   CD   OE1  OE2                                  
REMARK 470     ILE C 290    CG1  CG2  CD1                                       
REMARK 470     LEU C 291    CG   CD1  CD2                                       
REMARK 470     ASN C 292    CG   OD1  ND2                                       
REMARK 470     LYS C 293    CG   CD   CE   NZ                                   
REMARK 470     GLU C 297    CG   CD   OE1  OE2                                  
REMARK 470     SER C 298    OG                                                  
REMARK 470     ILE C 302    CG1  CG2  CD1                                       
REMARK 470     ARG C 303    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE C 306    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU C 329    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 331    CG   OD1  OD2                                       
REMARK 470     ILE C 333    CG1  CG2  CD1                                       
REMARK 470     CYS C 334    SG                                                  
REMARK 470     HIS C 347    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASP C 348    CG   OD1  OD2                                       
REMARK 470     GLN C 353    CG   CD   OE1  NE2                                  
REMARK 470     ILE C 358    CG1  CG2  CD1                                       
REMARK 470     ASP C 359    CG   OD1  OD2                                       
REMARK 470     VAL C 361    CG1  CG2                                            
REMARK 470     GLU C 362    CG   CD   OE1  OE2                                  
REMARK 470     GLN C 363    CG   CD   OE1  NE2                                  
REMARK 470     LEU C 364    CG   CD1  CD2                                       
REMARK 470     ASN C 366    CG   OD1  ND2                                       
REMARK 470     MET C 372    CG   SD   CE                                        
REMARK 470     LEU C 389    CG   CD1  CD2                                       
REMARK 470     GLU C 390    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 392    CG   CD   CE   NZ                                   
REMARK 470     MET C 393    CG   SD   CE                                        
REMARK 470     GLU C 394    CG   CD   OE1  OE2                                  
REMARK 470     ARG C 403    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG C 415    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C 434    CG   CD   CE   NZ                                   
REMARK 470     ASN C 435    CG   OD1  ND2                                       
REMARK 470     ARG C 446    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP C 479    CG   OD1  OD2                                       
REMARK 470     PHE C 480    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU C 481    CG   CD1  CD2                                       
REMARK 470     SER C 483    OG                                                  
REMARK 470     LEU C 484    CG   CD1  CD2                                       
REMARK 470     GLU C 485    CG   CD   OE1  OE2                                  
REMARK 470     ASN C 486    CG   OD1  ND2                                       
REMARK 470     ASP C 487    CG   OD1  OD2                                       
REMARK 470     ILE C 488    CG1  CG2  CD1                                       
REMARK 470     LYS C 489    CG   CD   CE   NZ                                   
REMARK 470     PHE C 492    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     THR C 494    OG1  CG2                                            
REMARK 470     ASN C 495    CG   OD1  ND2                                       
REMARK 470     GLN C 496    CG   CD   OE1  NE2                                  
REMARK 470     LYS D 217    CG   CD   CE   NZ                                   
REMARK 470     MET D 218    CG   SD   CE                                        
REMARK 470     LYS D 225    CG   CD   CE   NZ                                   
REMARK 470     ARG D 232    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG D 233    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG D 238    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN D 247    CG   CD   OE1  NE2                                  
REMARK 470     MET D 248    CG   SD   CE                                        
REMARK 470     LYS D 251    CG   CD   CE   NZ                                   
REMARK 470     HIS D 252    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS D 254    CG   CD   CE   NZ                                   
REMARK 470     LYS D 275    CG   CD   CE   NZ                                   
REMARK 470     LEU D 277    CG   CD1  CD2                                       
REMARK 470     ASN D 278    CG   OD1  ND2                                       
REMARK 470     ARG D 280    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU D 281    CG   CD   OE1  OE2                                  
REMARK 470     LYS D 283    CG   CD   CE   NZ                                   
REMARK 470     GLU D 289    CG   CD   OE1  OE2                                  
REMARK 470     ILE D 290    CG1  CG2  CD1                                       
REMARK 470     LEU D 291    CG   CD1  CD2                                       
REMARK 470     ASN D 292    CG   OD1  ND2                                       
REMARK 470     LYS D 293    CG   CD   CE   NZ                                   
REMARK 470     GLU D 297    CG   CD   OE1  OE2                                  
REMARK 470     SER D 298    OG                                                  
REMARK 470     ILE D 302    CG1  CG2  CD1                                       
REMARK 470     PHE D 306    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU D 310    CG   CD   OE1  OE2                                  
REMARK 470     GLN D 313    CG   CD   OE1  NE2                                  
REMARK 470     ARG D 314    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG D 315    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU D 329    CG   CD   OE1  OE2                                  
REMARK 470     ASP D 331    CG   OD1  OD2                                       
REMARK 470     ILE D 333    CG1  CG2  CD1                                       
REMARK 470     ASP D 348    CG   OD1  OD2                                       
REMARK 470     ASP D 359    CG   OD1  OD2                                       
REMARK 470     VAL D 361    CG1  CG2                                            
REMARK 470     GLU D 362    CG   CD   OE1  OE2                                  
REMARK 470     GLN D 363    CG   CD   OE1  NE2                                  
REMARK 470     LEU D 364    CG   CD1  CD2                                       
REMARK 470     ASN D 366    CG   OD1  ND2                                       
REMARK 470     ARG D 385    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU D 390    CG   CD   OE1  OE2                                  
REMARK 470     LYS D 392    CG   CD   CE   NZ                                   
REMARK 470     MET D 393    CG   SD   CE                                        
REMARK 470     GLU D 394    CG   CD   OE1  OE2                                  
REMARK 470     ARG D 403    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     MET D 414    CG   SD   CE                                        
REMARK 470     ARG D 415    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS D 434    CG   CD   CE   NZ                                   
REMARK 470     ASN D 435    CG   OD1  ND2                                       
REMARK 470     GLU D 442    CG   CD   OE1  OE2                                  
REMARK 470     ARG D 446    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE D 480    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU D 481    CG   CD1  CD2                                       
REMARK 470     SER D 483    OG                                                  
REMARK 470     LEU D 484    CG   CD1  CD2                                       
REMARK 470     GLU D 485    CG   CD   OE1  OE2                                  
REMARK 470     ASN D 486    CG   OD1  ND2                                       
REMARK 470     ASP D 487    CG   OD1  OD2                                       
REMARK 470     ILE D 488    CG1  CG2  CD1                                       
REMARK 470     LYS D 489    CG   CD   CE   NZ                                   
REMARK 470     PHE D 492    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     THR D 494    OG1  CG2                                            
REMARK 470     ASN D 495    CG   OD1  ND2                                       
REMARK 470     GLN D 496    CG   CD   OE1  NE2                                  
REMARK 470     GLU D 497    CG   CD   OE1  OE2                                  
REMARK 470     LYS E 217    CG   CD   CE   NZ                                   
REMARK 470     MET E 218    CG   SD   CE                                        
REMARK 470     ARG E 232    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG E 238    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN E 247    CG   CD   OE1  NE2                                  
REMARK 470     MET E 248    CG   SD   CE                                        
REMARK 470     LYS E 251    CG   CD   CE   NZ                                   
REMARK 470     LYS E 254    CG   CD   CE   NZ                                   
REMARK 470     LYS E 275    CG   CD   CE   NZ                                   
REMARK 470     MET E 276    CG   SD   CE                                        
REMARK 470     LEU E 277    CG   CD1  CD2                                       
REMARK 470     ASN E 278    CG   OD1  ND2                                       
REMARK 470     ARG E 280    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU E 281    CG   CD   OE1  OE2                                  
REMARK 470     LYS E 283    CG   CD   CE   NZ                                   
REMARK 470     GLU E 289    CG   CD   OE1  OE2                                  
REMARK 470     ILE E 290    CG1  CG2  CD1                                       
REMARK 470     LEU E 291    CG   CD1  CD2                                       
REMARK 470     ASN E 292    CG   OD1  ND2                                       
REMARK 470     LYS E 293    CG   CD   CE   NZ                                   
REMARK 470     GLU E 297    CG   CD   OE1  OE2                                  
REMARK 470     SER E 298    OG                                                  
REMARK 470     ILE E 302    CG1  CG2  CD1                                       
REMARK 470     GLN E 313    CG   CD   OE1  NE2                                  
REMARK 470     ARG E 315    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU E 329    CG   CD   OE1  OE2                                  
REMARK 470     HIS E 347    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASP E 348    CG   OD1  OD2                                       
REMARK 470     THR E 349    OG1  CG2                                            
REMARK 470     ASP E 359    CG   OD1  OD2                                       
REMARK 470     VAL E 361    CG1  CG2                                            
REMARK 470     GLU E 362    CG   CD   OE1  OE2                                  
REMARK 470     GLN E 363    CG   CD   OE1  NE2                                  
REMARK 470     LEU E 364    CG   CD1  CD2                                       
REMARK 470     ASN E 366    CG   OD1  ND2                                       
REMARK 470     GLU E 390    CG   CD   OE1  OE2                                  
REMARK 470     LYS E 392    CG   CD   CE   NZ                                   
REMARK 470     MET E 393    CG   SD   CE                                        
REMARK 470     GLU E 394    CG   CD   OE1  OE2                                  
REMARK 470     ARG E 403    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG E 415    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS E 434    CG   CD   CE   NZ                                   
REMARK 470     ASN E 435    CG   OD1  ND2                                       
REMARK 470     ARG E 446    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP E 479    CG   OD1  OD2                                       
REMARK 470     PHE E 480    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU E 481    CG   CD1  CD2                                       
REMARK 470     SER E 483    OG                                                  
REMARK 470     LEU E 484    CG   CD1  CD2                                       
REMARK 470     GLU E 485    CG   CD   OE1  OE2                                  
REMARK 470     ASN E 486    CG   OD1  ND2                                       
REMARK 470     ASP E 487    CG   OD1  OD2                                       
REMARK 470     ILE E 488    CG1  CG2  CD1                                       
REMARK 470     LYS E 489    CG   CD   CE   NZ                                   
REMARK 470     PHE E 492    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     THR E 494    OG1  CG2                                            
REMARK 470     LEU E 540    CG   CD1  CD2                                       
REMARK 470     GLU E 542    CG   CD   OE1  OE2                                  
REMARK 470     ILE E 707    CG1  CG2  CD1                                       
REMARK 470     ASN F  20    CG   OD1  ND2                                       
REMARK 470     LYS F 217    CG   CD   CE   NZ                                   
REMARK 470     MET F 218    CG   SD   CE                                        
REMARK 470     ARG F 238    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN F 247    CG   CD   OE1  NE2                                  
REMARK 470     MET F 248    CG   SD   CE                                        
REMARK 470     LYS F 251    CG   CD   CE   NZ                                   
REMARK 470     LYS F 254    CG   CD   CE   NZ                                   
REMARK 470     LYS F 275    CG   CD   CE   NZ                                   
REMARK 470     MET F 276    CG   SD   CE                                        
REMARK 470     LEU F 277    CG   CD1  CD2                                       
REMARK 470     ASN F 278    CG   OD1  ND2                                       
REMARK 470     ARG F 280    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU F 281    CG   CD   OE1  OE2                                  
REMARK 470     LYS F 283    CG   CD   CE   NZ                                   
REMARK 470     GLU F 289    CG   CD   OE1  OE2                                  
REMARK 470     ILE F 290    CG1  CG2  CD1                                       
REMARK 470     LEU F 291    CG   CD1  CD2                                       
REMARK 470     ASN F 292    CG   OD1  ND2                                       
REMARK 470     LYS F 293    CG   CD   CE   NZ                                   
REMARK 470     GLU F 297    CG   CD   OE1  OE2                                  
REMARK 470     SER F 298    OG                                                  
REMARK 470     ILE F 302    CG1  CG2  CD1                                       
REMARK 470     ARG F 315    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU F 316    CG   CD1  CD2                                       
REMARK 470     GLU F 329    CG   CD   OE1  OE2                                  
REMARK 470     HIS F 347    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASP F 348    CG   OD1  OD2                                       
REMARK 470     ASP F 359    CG   OD1  OD2                                       
REMARK 470     VAL F 361    CG1  CG2                                            
REMARK 470     GLU F 362    CG   CD   OE1  OE2                                  
REMARK 470     GLN F 363    CG   CD   OE1  NE2                                  
REMARK 470     LEU F 364    CG   CD1  CD2                                       
REMARK 470     ASN F 366    CG   OD1  ND2                                       
REMARK 470     GLU F 390    CG   CD   OE1  OE2                                  
REMARK 470     LYS F 392    CG   CD   CE   NZ                                   
REMARK 470     MET F 393    CG   SD   CE                                        
REMARK 470     GLU F 394    CG   CD   OE1  OE2                                  
REMARK 470     ARG F 403    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG F 415    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS F 434    CG   CD   CE   NZ                                   
REMARK 470     ASN F 435    CG   OD1  ND2                                       
REMARK 470     ARG F 446    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN F 505    CG   OD1  ND2                                       
REMARK 470     ILE F 508    CG1  CG2  CD1                                       
REMARK 470     VAL F 514    CG1  CG2                                            
REMARK 470     THR F 528    OG1  CG2                                            
REMARK 470     HIS F 546    CG   ND1  CD2  CE1  NE2                             
REMARK 470     THR F 550    OG1  CG2                                            
REMARK 470     LYS F 555    CG   CD   CE   NZ                                   
REMARK 470     LYS I 222    CG   CD   CE   NZ                                   
REMARK 470     GLN K  71    CG   CD   OE1  NE2                                  
REMARK 470     LYS M  83    CG   CD   CE   NZ                                   
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OH   TYR J   228     OD1  ASP J   237              1.88            
REMARK 500   OG   SER A   569     OD1  ASP A   571              1.89            
REMARK 500   NZ   LYS A   549     OG   SER A   647              1.93            
REMARK 500   OD2  ASP E   603     OG1  THR E   645              1.97            
REMARK 500   O    GLN E   527     OG   SER E   531              1.99            
REMARK 500   OE2  GLU E   606     OG1  THR E   646              1.99            
REMARK 500   O    PHE F   564     OG   SER F   598              2.00            
REMARK 500   OG   SER F   569     OD2  ASP F   571              2.01            
REMARK 500   O    ALA A   557     OG   SER A   560              2.03            
REMARK 500   O    PRO C   544     OG   SER C   547              2.03            
REMARK 500   OG1  THR A   672     OE1  GLN A   675              2.05            
REMARK 500   O    GLU C   497     N    TYR C   499              2.06            
REMARK 500   O    GLN C   313     N    GLY C   317              2.07            
REMARK 500   OD1  ASN A   685     NH1  ARG F   533              2.07            
REMARK 500   OH   TYR G   228     OD1  ASP G   237              2.07            
REMARK 500   NE2  GLN A   449     O    MET F   248              2.08            
REMARK 500   O    PHE C   564     OG   SER C   598              2.08            
REMARK 500   OG   SER D    73     OD1  ASP J   217              2.08            
REMARK 500   O    LEU A   316     OG   SER A   320              2.10            
REMARK 500   NE2  GLN E   624     OD1  ASP F   610              2.11            
REMARK 500   O    TYR E   593     NH1  ARG E   638              2.13            
REMARK 500   O    GLU A   497     N    TYR A   499              2.14            
REMARK 500   O    VAL E   525     OG1  THR E   528              2.14            
REMARK 500   OE1  GLU D   312     ND1  HIS D   323              2.15            
REMARK 500   OE1  GLU B   311     NE   ARG B   314              2.15            
REMARK 500   OG   SER J   159     O    VAL M    48              2.15            
REMARK 500   OE1  GLU B   656     NH2  ARG C   648              2.16            
REMARK 500   NZ   LYS B   581     O    LEU B   608              2.16            
REMARK 500   OG1  THR A   267     OD2  ASP A   328              2.16            
REMARK 500   O    LYS C   689     OG1  THR C   692              2.17            
REMARK 500   O    ASP D   399     N    ARG D   403              2.17            
REMARK 500   O    ASN G   158     ND2  ASN G   162              2.17            
REMARK 500   OG   SER J   160     OE2  GLU M    52              2.18            
REMARK 500   O    THR E   693     NE2  GLN E   697              2.18            
REMARK 500   O    GLN C   496     N    ASP C   498              2.19            
REMARK 500   O    GLU E   246     NH1  ARG F   413              2.19            
REMARK 500   O    LEU C   718     NH1  ARG C   725              2.19            
REMARK 500   O    GLY E   706     N    LEU E   710              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    SER A 320   CB    SER A 320   OG     -0.087                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    PRO A 242   C   -  N   -  CD  ANGL. DEV. =  14.0 DEGREES          
REMARK 500    PRO A 262   C   -  N   -  CA  ANGL. DEV. =  16.3 DEGREES          
REMARK 500    PRO A 262   C   -  N   -  CD  ANGL. DEV. = -22.2 DEGREES          
REMARK 500    LEU A 322   CA  -  CB  -  CG  ANGL. DEV. =  14.6 DEGREES          
REMARK 500    LEU A 552   CA  -  CB  -  CG  ANGL. DEV. =  16.2 DEGREES          
REMARK 500    LEU A 597   CB  -  CG  -  CD2 ANGL. DEV. = -17.1 DEGREES          
REMARK 500    PRO B 288   C   -  N   -  CA  ANGL. DEV. =  10.1 DEGREES          
REMARK 500    LEU B 305   CA  -  CB  -  CG  ANGL. DEV. =  15.7 DEGREES          
REMARK 500    ILE B 395   CG1 -  CB  -  CG2 ANGL. DEV. = -13.5 DEGREES          
REMARK 500    LYS B 708   CD  -  CE  -  NZ  ANGL. DEV. =  33.6 DEGREES          
REMARK 500    LEU C 322   CA  -  CB  -  CG  ANGL. DEV. =  18.9 DEGREES          
REMARK 500    LEU C 677   CA  -  CB  -  CG  ANGL. DEV. =  14.6 DEGREES          
REMARK 500    ASN D 505   C   -  N   -  CA  ANGL. DEV. = -19.8 DEGREES          
REMARK 500    LEU D 609   CA  -  CB  -  CG  ANGL. DEV. =  14.0 DEGREES          
REMARK 500    LEU D 627   CB  -  CG  -  CD2 ANGL. DEV. = -10.5 DEGREES          
REMARK 500    LEU D 713   CB  -  CG  -  CD2 ANGL. DEV. = -13.9 DEGREES          
REMARK 500    LEU E 305   CA  -  CB  -  CG  ANGL. DEV. =  15.7 DEGREES          
REMARK 500    LYS E 549   CB  -  CG  -  CD  ANGL. DEV. =  18.3 DEGREES          
REMARK 500    LEU E 552   CA  -  CB  -  CG  ANGL. DEV. =  13.9 DEGREES          
REMARK 500    LEU E 629   CB  -  CG  -  CD1 ANGL. DEV. = -12.2 DEGREES          
REMARK 500    LEU E 652   CB  -  CG  -  CD2 ANGL. DEV. = -11.1 DEGREES          
REMARK 500    LEU F 305   CA  -  CB  -  CG  ANGL. DEV. =  16.8 DEGREES          
REMARK 500    LEU F 397   CA  -  CB  -  CG  ANGL. DEV. =  21.0 DEGREES          
REMARK 500    LEU F 518   CB  -  CG  -  CD1 ANGL. DEV. = -17.8 DEGREES          
REMARK 500    LEU F 609   CB  -  CG  -  CD2 ANGL. DEV. = -10.7 DEGREES          
REMARK 500    ASP J  96   CB  -  CG  -  OD1 ANGL. DEV. =   6.3 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASP A  28      -72.70   -112.85                                   
REMARK 500    TYR A  29     -166.86   -111.09                                   
REMARK 500    HIS A  52      117.79   -167.20                                   
REMARK 500    PRO A  53       26.35    -61.75                                   
REMARK 500    LYS A  87       71.52    -65.75                                   
REMARK 500    ALA A  88      -12.55   -170.83                                   
REMARK 500    LYS A  89      -13.91   -148.46                                   
REMARK 500    LYS A 105       22.02    -67.04                                   
REMARK 500    ASN A 106        9.19   -151.19                                   
REMARK 500    ASP A 142       19.13     57.70                                   
REMARK 500    ASN A 180       51.97    -94.25                                   
REMARK 500    LYS A 200     -142.63   -141.81                                   
REMARK 500    LEU A 223       20.80     32.39                                   
REMARK 500    CYS A 264     -168.24    168.74                                   
REMARK 500    ARG A 280       -0.74     84.31                                   
REMARK 500    LYS A 293      -76.54    129.38                                   
REMARK 500    TYR A 294      -68.31    154.34                                   
REMARK 500    ALA A 318      -65.65    161.69                                   
REMARK 500    ILE A 333     -115.92    -68.46                                   
REMARK 500    GLN A 363     -127.73     56.09                                   
REMARK 500    ASN A 366       12.12     88.44                                   
REMARK 500    LEU A 397     -135.26     54.17                                   
REMARK 500    PHE A 480     -129.64     54.20                                   
REMARK 500    ALA A 491      157.53     85.48                                   
REMARK 500    THR A 494      163.71     87.28                                   
REMARK 500    ASP A 498      -46.03      7.96                                   
REMARK 500    MET A 504      -63.12     67.49                                   
REMARK 500    HIS A 546        7.13     84.47                                   
REMARK 500    ALA A 671      -36.93   -134.10                                   
REMARK 500    GLU A 736       48.01    -94.72                                   
REMARK 500    PRO B  12      -83.62    -51.21                                   
REMARK 500    PRO B  41       -4.30    -54.64                                   
REMARK 500    ASN B  42       35.47   -141.42                                   
REMARK 500    SER B  73      111.13   -178.20                                   
REMARK 500    ASP B  86       61.59   -110.08                                   
REMARK 500    LYS B  87      -48.05    -25.04                                   
REMARK 500    ALA B  88       28.41    -68.28                                   
REMARK 500    LYS B  89      -21.29   -176.38                                   
REMARK 500    ASP B 100      138.63   -170.23                                   
REMARK 500    PHE B 125       47.39   -102.84                                   
REMARK 500    VAL B 178     -169.02   -117.51                                   
REMARK 500    ALA B 188     -170.40    -69.57                                   
REMARK 500    ASN B 190       39.38     36.76                                   
REMARK 500    LYS B 200     -136.14    -93.99                                   
REMARK 500    LYS B 283      131.63     11.90                                   
REMARK 500    ILE B 290      -54.34     69.22                                   
REMARK 500    LYS B 293       97.81     93.65                                   
REMARK 500    GLU B 297      -65.26    159.04                                   
REMARK 500    ALA B 318      -68.22    156.59                                   
REMARK 500    ASP B 348     -125.93     58.83                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     297 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 PRO A  241     PRO A  242                  -31.06                    
REMARK 500 GLY B  438     ALA B  439                  143.68                    
REMARK 500 GLY E  438     ALA E  439                  143.07                    
REMARK 500 GLY F  438     ALA F  439                  142.72                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-6206   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-6204   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-6205   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-6207   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-6208   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-6209   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-6210   RELATED DB: EMDB                              
REMARK 900 RELATED ID: 3J94   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 3J95   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 3J97   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 3J98   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 3J99   RELATED DB: PDB                                   
DBREF  3J96 A    1   744  UNP    P18708   NSF_CRIGR        1    744             
DBREF  3J96 B    1   744  UNP    P18708   NSF_CRIGR        1    744             
DBREF  3J96 C    1   744  UNP    P18708   NSF_CRIGR        1    744             
DBREF  3J96 D    1   744  UNP    P18708   NSF_CRIGR        1    744             
DBREF  3J96 E    1   744  UNP    P18708   NSF_CRIGR        1    744             
DBREF  3J96 F    1   744  UNP    P18708   NSF_CRIGR        1    744             
DBREF  3J96 G    1   295  UNP    P54921   SNAA_RAT         1    295             
DBREF  3J96 H    1   295  UNP    P54921   SNAA_RAT         1    295             
DBREF  3J96 I    1   295  UNP    P54921   SNAA_RAT         1    295             
DBREF  3J96 J    1   295  UNP    P54921   SNAA_RAT         1    295             
DBREF  3J96 K   28    89  UNP    P63045   VAMP2_RAT       28     89             
DBREF  3J96 L  191   256  UNP    P32851   STX1A_RAT      191    256             
DBREF  3J96 M   17   204  PDB    3J96     3J96            17    204             
SEQADV 3J96 GLY A   -2  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 ALA A   -1  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 HIS A    0  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 GLY B   -2  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 ALA B   -1  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 HIS B    0  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 GLY C   -2  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 ALA C   -1  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 HIS C    0  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 GLY D   -2  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 ALA D   -1  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 HIS D    0  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 GLY E   -2  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 ALA E   -1  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 HIS E    0  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 GLY F   -2  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 ALA F   -1  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 HIS F    0  UNP  P18708              EXPRESSION TAG                 
SEQADV 3J96 GLY G   -1  UNP  P54921              EXPRESSION TAG                 
SEQADV 3J96 SER G    0  UNP  P54921              EXPRESSION TAG                 
SEQADV 3J96 GLY H   -1  UNP  P54921              EXPRESSION TAG                 
SEQADV 3J96 SER H    0  UNP  P54921              EXPRESSION TAG                 
SEQADV 3J96 GLY I   -1  UNP  P54921              EXPRESSION TAG                 
SEQADV 3J96 SER I    0  UNP  P54921              EXPRESSION TAG                 
SEQADV 3J96 GLY J   -1  UNP  P54921              EXPRESSION TAG                 
SEQADV 3J96 SER J    0  UNP  P54921              EXPRESSION TAG                 
SEQADV 3J96 GLY K   27  UNP  P63045              EXPRESSION TAG                 
SEQADV 3J96 MET L  190  UNP  P32851              EXPRESSION TAG                 
SEQRES   1 A  747  GLY ALA HIS MET ALA GLY ARG SER MET GLN ALA ALA ARG          
SEQRES   2 A  747  CYS PRO THR ASP GLU LEU SER LEU SER ASN CYS ALA VAL          
SEQRES   3 A  747  VAL SER GLU LYS ASP TYR GLN SER GLY GLN HIS VAL ILE          
SEQRES   4 A  747  VAL ARG THR SER PRO ASN HIS LYS TYR ILE PHE THR LEU          
SEQRES   5 A  747  ARG THR HIS PRO SER VAL VAL PRO GLY SER VAL ALA PHE          
SEQRES   6 A  747  SER LEU PRO GLN ARG LYS TRP ALA GLY LEU SER ILE GLY          
SEQRES   7 A  747  GLN GLU ILE GLU VAL ALA LEU TYR SER PHE ASP LYS ALA          
SEQRES   8 A  747  LYS GLN CYS ILE GLY THR MET THR ILE GLU ILE ASP PHE          
SEQRES   9 A  747  LEU GLN LYS LYS ASN ILE ASP SER ASN PRO TYR ASP THR          
SEQRES  10 A  747  ASP LYS MET ALA ALA GLU PHE ILE GLN GLN PHE ASN ASN          
SEQRES  11 A  747  GLN ALA PHE SER VAL GLY GLN GLN LEU VAL PHE SER PHE          
SEQRES  12 A  747  ASN ASP LYS LEU PHE GLY LEU LEU VAL LYS ASP ILE GLU          
SEQRES  13 A  747  ALA MET ASP PRO SER ILE LEU LYS GLY GLU PRO ALA SER          
SEQRES  14 A  747  GLY LYS ARG GLN LYS ILE GLU VAL GLY LEU VAL VAL GLY          
SEQRES  15 A  747  ASN SER GLN VAL ALA PHE GLU LYS ALA GLU ASN SER SER          
SEQRES  16 A  747  LEU ASN LEU ILE GLY LYS ALA LYS THR LYS GLU ASN ARG          
SEQRES  17 A  747  GLN SER ILE ILE ASN PRO ASP TRP ASN PHE GLU LYS MET          
SEQRES  18 A  747  GLY ILE GLY GLY LEU ASP LYS GLU PHE SER ASP ILE PHE          
SEQRES  19 A  747  ARG ARG ALA PHE ALA SER ARG VAL PHE PRO PRO GLU ILE          
SEQRES  20 A  747  VAL GLU GLN MET GLY CYS LYS HIS VAL LYS GLY ILE LEU          
SEQRES  21 A  747  LEU TYR GLY PRO PRO GLY CYS GLY LYS THR LEU LEU ALA          
SEQRES  22 A  747  ARG GLN ILE GLY LYS MET LEU ASN ALA ARG GLU PRO LYS          
SEQRES  23 A  747  VAL VAL ASN GLY PRO GLU ILE LEU ASN LYS TYR VAL GLY          
SEQRES  24 A  747  GLU SER GLU ALA ASN ILE ARG LYS LEU PHE ALA ASP ALA          
SEQRES  25 A  747  GLU GLU GLU GLN ARG ARG LEU GLY ALA ASN SER GLY LEU          
SEQRES  26 A  747  HIS ILE ILE ILE PHE ASP GLU ILE ASP ALA ILE CYS LYS          
SEQRES  27 A  747  GLN ARG GLY SER MET ALA GLY SER THR GLY VAL HIS ASP          
SEQRES  28 A  747  THR VAL VAL ASN GLN LEU LEU SER LYS ILE ASP GLY VAL          
SEQRES  29 A  747  GLU GLN LEU ASN ASN ILE LEU VAL ILE GLY MET THR ASN          
SEQRES  30 A  747  ARG PRO ASP LEU ILE ASP GLU ALA LEU LEU ARG PRO GLY          
SEQRES  31 A  747  ARG LEU GLU VAL LYS MET GLU ILE GLY LEU PRO ASP GLU          
SEQRES  32 A  747  LYS GLY ARG LEU GLN ILE LEU HIS ILE HIS THR ALA ARG          
SEQRES  33 A  747  MET ARG GLY HIS GLN LEU LEU SER ALA ASP VAL ASP ILE          
SEQRES  34 A  747  LYS GLU LEU ALA VAL GLU THR LYS ASN PHE SER GLY ALA          
SEQRES  35 A  747  GLU LEU GLU GLY LEU VAL ARG ALA ALA GLN SER THR ALA          
SEQRES  36 A  747  MET ASN ARG HIS ILE LYS ALA SER THR LYS VAL GLU VAL          
SEQRES  37 A  747  ASP MET GLU LYS ALA GLU SER LEU GLN VAL THR ARG GLY          
SEQRES  38 A  747  ASP PHE LEU ALA SER LEU GLU ASN ASP ILE LYS PRO ALA          
SEQRES  39 A  747  PHE GLY THR ASN GLN GLU ASP TYR ALA SER TYR ILE MET          
SEQRES  40 A  747  ASN GLY ILE ILE LYS TRP GLY ASP PRO VAL THR ARG VAL          
SEQRES  41 A  747  LEU ASP ASP GLY GLU LEU LEU VAL GLN GLN THR LYS ASN          
SEQRES  42 A  747  SER ASP ARG THR PRO LEU VAL SER VAL LEU LEU GLU GLY          
SEQRES  43 A  747  PRO PRO HIS SER GLY LYS THR ALA LEU ALA ALA LYS ILE          
SEQRES  44 A  747  ALA GLU GLU SER ASN PHE PRO PHE ILE LYS ILE CYS SER          
SEQRES  45 A  747  PRO ASP LYS MET ILE GLY PHE SER GLU THR ALA LYS CYS          
SEQRES  46 A  747  GLN ALA MET LYS LYS ILE PHE ASP ASP ALA TYR LYS SER          
SEQRES  47 A  747  GLN LEU SER CYS VAL VAL VAL ASP ASP ILE GLU ARG LEU          
SEQRES  48 A  747  LEU ASP TYR VAL PRO ILE GLY PRO ARG PHE SER ASN LEU          
SEQRES  49 A  747  VAL LEU GLN ALA LEU LEU VAL LEU LEU LYS LYS ALA PRO          
SEQRES  50 A  747  PRO GLN GLY ARG LYS LEU LEU ILE ILE GLY THR THR SER          
SEQRES  51 A  747  ARG LYS ASP VAL LEU GLN GLU MET GLU MET LEU ASN ALA          
SEQRES  52 A  747  PHE SER THR THR ILE HIS VAL PRO ASN ILE ALA THR GLY          
SEQRES  53 A  747  GLU GLN LEU LEU GLU ALA LEU GLU LEU LEU GLY ASN PHE          
SEQRES  54 A  747  LYS ASP LYS GLU ARG THR THR ILE ALA GLN GLN VAL LYS          
SEQRES  55 A  747  GLY LYS LYS VAL TRP ILE GLY ILE LYS LYS LEU LEU MET          
SEQRES  56 A  747  LEU ILE GLU MET SER LEU GLN MET ASP PRO GLU TYR ARG          
SEQRES  57 A  747  VAL ARG LYS PHE LEU ALA LEU LEU ARG GLU GLU GLY ALA          
SEQRES  58 A  747  SER PRO LEU ASP PHE ASP                                      
SEQRES   1 B  747  GLY ALA HIS MET ALA GLY ARG SER MET GLN ALA ALA ARG          
SEQRES   2 B  747  CYS PRO THR ASP GLU LEU SER LEU SER ASN CYS ALA VAL          
SEQRES   3 B  747  VAL SER GLU LYS ASP TYR GLN SER GLY GLN HIS VAL ILE          
SEQRES   4 B  747  VAL ARG THR SER PRO ASN HIS LYS TYR ILE PHE THR LEU          
SEQRES   5 B  747  ARG THR HIS PRO SER VAL VAL PRO GLY SER VAL ALA PHE          
SEQRES   6 B  747  SER LEU PRO GLN ARG LYS TRP ALA GLY LEU SER ILE GLY          
SEQRES   7 B  747  GLN GLU ILE GLU VAL ALA LEU TYR SER PHE ASP LYS ALA          
SEQRES   8 B  747  LYS GLN CYS ILE GLY THR MET THR ILE GLU ILE ASP PHE          
SEQRES   9 B  747  LEU GLN LYS LYS ASN ILE ASP SER ASN PRO TYR ASP THR          
SEQRES  10 B  747  ASP LYS MET ALA ALA GLU PHE ILE GLN GLN PHE ASN ASN          
SEQRES  11 B  747  GLN ALA PHE SER VAL GLY GLN GLN LEU VAL PHE SER PHE          
SEQRES  12 B  747  ASN ASP LYS LEU PHE GLY LEU LEU VAL LYS ASP ILE GLU          
SEQRES  13 B  747  ALA MET ASP PRO SER ILE LEU LYS GLY GLU PRO ALA SER          
SEQRES  14 B  747  GLY LYS ARG GLN LYS ILE GLU VAL GLY LEU VAL VAL GLY          
SEQRES  15 B  747  ASN SER GLN VAL ALA PHE GLU LYS ALA GLU ASN SER SER          
SEQRES  16 B  747  LEU ASN LEU ILE GLY LYS ALA LYS THR LYS GLU ASN ARG          
SEQRES  17 B  747  GLN SER ILE ILE ASN PRO ASP TRP ASN PHE GLU LYS MET          
SEQRES  18 B  747  GLY ILE GLY GLY LEU ASP LYS GLU PHE SER ASP ILE PHE          
SEQRES  19 B  747  ARG ARG ALA PHE ALA SER ARG VAL PHE PRO PRO GLU ILE          
SEQRES  20 B  747  VAL GLU GLN MET GLY CYS LYS HIS VAL LYS GLY ILE LEU          
SEQRES  21 B  747  LEU TYR GLY PRO PRO GLY CYS GLY LYS THR LEU LEU ALA          
SEQRES  22 B  747  ARG GLN ILE GLY LYS MET LEU ASN ALA ARG GLU PRO LYS          
SEQRES  23 B  747  VAL VAL ASN GLY PRO GLU ILE LEU ASN LYS TYR VAL GLY          
SEQRES  24 B  747  GLU SER GLU ALA ASN ILE ARG LYS LEU PHE ALA ASP ALA          
SEQRES  25 B  747  GLU GLU GLU GLN ARG ARG LEU GLY ALA ASN SER GLY LEU          
SEQRES  26 B  747  HIS ILE ILE ILE PHE ASP GLU ILE ASP ALA ILE CYS LYS          
SEQRES  27 B  747  GLN ARG GLY SER MET ALA GLY SER THR GLY VAL HIS ASP          
SEQRES  28 B  747  THR VAL VAL ASN GLN LEU LEU SER LYS ILE ASP GLY VAL          
SEQRES  29 B  747  GLU GLN LEU ASN ASN ILE LEU VAL ILE GLY MET THR ASN          
SEQRES  30 B  747  ARG PRO ASP LEU ILE ASP GLU ALA LEU LEU ARG PRO GLY          
SEQRES  31 B  747  ARG LEU GLU VAL LYS MET GLU ILE GLY LEU PRO ASP GLU          
SEQRES  32 B  747  LYS GLY ARG LEU GLN ILE LEU HIS ILE HIS THR ALA ARG          
SEQRES  33 B  747  MET ARG GLY HIS GLN LEU LEU SER ALA ASP VAL ASP ILE          
SEQRES  34 B  747  LYS GLU LEU ALA VAL GLU THR LYS ASN PHE SER GLY ALA          
SEQRES  35 B  747  GLU LEU GLU GLY LEU VAL ARG ALA ALA GLN SER THR ALA          
SEQRES  36 B  747  MET ASN ARG HIS ILE LYS ALA SER THR LYS VAL GLU VAL          
SEQRES  37 B  747  ASP MET GLU LYS ALA GLU SER LEU GLN VAL THR ARG GLY          
SEQRES  38 B  747  ASP PHE LEU ALA SER LEU GLU ASN ASP ILE LYS PRO ALA          
SEQRES  39 B  747  PHE GLY THR ASN GLN GLU ASP TYR ALA SER TYR ILE MET          
SEQRES  40 B  747  ASN GLY ILE ILE LYS TRP GLY ASP PRO VAL THR ARG VAL          
SEQRES  41 B  747  LEU ASP ASP GLY GLU LEU LEU VAL GLN GLN THR LYS ASN          
SEQRES  42 B  747  SER ASP ARG THR PRO LEU VAL SER VAL LEU LEU GLU GLY          
SEQRES  43 B  747  PRO PRO HIS SER GLY LYS THR ALA LEU ALA ALA LYS ILE          
SEQRES  44 B  747  ALA GLU GLU SER ASN PHE PRO PHE ILE LYS ILE CYS SER          
SEQRES  45 B  747  PRO ASP LYS MET ILE GLY PHE SER GLU THR ALA LYS CYS          
SEQRES  46 B  747  GLN ALA MET LYS LYS ILE PHE ASP ASP ALA TYR LYS SER          
SEQRES  47 B  747  GLN LEU SER CYS VAL VAL VAL ASP ASP ILE GLU ARG LEU          
SEQRES  48 B  747  LEU ASP TYR VAL PRO ILE GLY PRO ARG PHE SER ASN LEU          
SEQRES  49 B  747  VAL LEU GLN ALA LEU LEU VAL LEU LEU LYS LYS ALA PRO          
SEQRES  50 B  747  PRO GLN GLY ARG LYS LEU LEU ILE ILE GLY THR THR SER          
SEQRES  51 B  747  ARG LYS ASP VAL LEU GLN GLU MET GLU MET LEU ASN ALA          
SEQRES  52 B  747  PHE SER THR THR ILE HIS VAL PRO ASN ILE ALA THR GLY          
SEQRES  53 B  747  GLU GLN LEU LEU GLU ALA LEU GLU LEU LEU GLY ASN PHE          
SEQRES  54 B  747  LYS ASP LYS GLU ARG THR THR ILE ALA GLN GLN VAL LYS          
SEQRES  55 B  747  GLY LYS LYS VAL TRP ILE GLY ILE LYS LYS LEU LEU MET          
SEQRES  56 B  747  LEU ILE GLU MET SER LEU GLN MET ASP PRO GLU TYR ARG          
SEQRES  57 B  747  VAL ARG LYS PHE LEU ALA LEU LEU ARG GLU GLU GLY ALA          
SEQRES  58 B  747  SER PRO LEU ASP PHE ASP                                      
SEQRES   1 C  747  GLY ALA HIS MET ALA GLY ARG SER MET GLN ALA ALA ARG          
SEQRES   2 C  747  CYS PRO THR ASP GLU LEU SER LEU SER ASN CYS ALA VAL          
SEQRES   3 C  747  VAL SER GLU LYS ASP TYR GLN SER GLY GLN HIS VAL ILE          
SEQRES   4 C  747  VAL ARG THR SER PRO ASN HIS LYS TYR ILE PHE THR LEU          
SEQRES   5 C  747  ARG THR HIS PRO SER VAL VAL PRO GLY SER VAL ALA PHE          
SEQRES   6 C  747  SER LEU PRO GLN ARG LYS TRP ALA GLY LEU SER ILE GLY          
SEQRES   7 C  747  GLN GLU ILE GLU VAL ALA LEU TYR SER PHE ASP LYS ALA          
SEQRES   8 C  747  LYS GLN CYS ILE GLY THR MET THR ILE GLU ILE ASP PHE          
SEQRES   9 C  747  LEU GLN LYS LYS ASN ILE ASP SER ASN PRO TYR ASP THR          
SEQRES  10 C  747  ASP LYS MET ALA ALA GLU PHE ILE GLN GLN PHE ASN ASN          
SEQRES  11 C  747  GLN ALA PHE SER VAL GLY GLN GLN LEU VAL PHE SER PHE          
SEQRES  12 C  747  ASN ASP LYS LEU PHE GLY LEU LEU VAL LYS ASP ILE GLU          
SEQRES  13 C  747  ALA MET ASP PRO SER ILE LEU LYS GLY GLU PRO ALA SER          
SEQRES  14 C  747  GLY LYS ARG GLN LYS ILE GLU VAL GLY LEU VAL VAL GLY          
SEQRES  15 C  747  ASN SER GLN VAL ALA PHE GLU LYS ALA GLU ASN SER SER          
SEQRES  16 C  747  LEU ASN LEU ILE GLY LYS ALA LYS THR LYS GLU ASN ARG          
SEQRES  17 C  747  GLN SER ILE ILE ASN PRO ASP TRP ASN PHE GLU LYS MET          
SEQRES  18 C  747  GLY ILE GLY GLY LEU ASP LYS GLU PHE SER ASP ILE PHE          
SEQRES  19 C  747  ARG ARG ALA PHE ALA SER ARG VAL PHE PRO PRO GLU ILE          
SEQRES  20 C  747  VAL GLU GLN MET GLY CYS LYS HIS VAL LYS GLY ILE LEU          
SEQRES  21 C  747  LEU TYR GLY PRO PRO GLY CYS GLY LYS THR LEU LEU ALA          
SEQRES  22 C  747  ARG GLN ILE GLY LYS MET LEU ASN ALA ARG GLU PRO LYS          
SEQRES  23 C  747  VAL VAL ASN GLY PRO GLU ILE LEU ASN LYS TYR VAL GLY          
SEQRES  24 C  747  GLU SER GLU ALA ASN ILE ARG LYS LEU PHE ALA ASP ALA          
SEQRES  25 C  747  GLU GLU GLU GLN ARG ARG LEU GLY ALA ASN SER GLY LEU          
SEQRES  26 C  747  HIS ILE ILE ILE PHE ASP GLU ILE ASP ALA ILE CYS LYS          
SEQRES  27 C  747  GLN ARG GLY SER MET ALA GLY SER THR GLY VAL HIS ASP          
SEQRES  28 C  747  THR VAL VAL ASN GLN LEU LEU SER LYS ILE ASP GLY VAL          
SEQRES  29 C  747  GLU GLN LEU ASN ASN ILE LEU VAL ILE GLY MET THR ASN          
SEQRES  30 C  747  ARG PRO ASP LEU ILE ASP GLU ALA LEU LEU ARG PRO GLY          
SEQRES  31 C  747  ARG LEU GLU VAL LYS MET GLU ILE GLY LEU PRO ASP GLU          
SEQRES  32 C  747  LYS GLY ARG LEU GLN ILE LEU HIS ILE HIS THR ALA ARG          
SEQRES  33 C  747  MET ARG GLY HIS GLN LEU LEU SER ALA ASP VAL ASP ILE          
SEQRES  34 C  747  LYS GLU LEU ALA VAL GLU THR LYS ASN PHE SER GLY ALA          
SEQRES  35 C  747  GLU LEU GLU GLY LEU VAL ARG ALA ALA GLN SER THR ALA          
SEQRES  36 C  747  MET ASN ARG HIS ILE LYS ALA SER THR LYS VAL GLU VAL          
SEQRES  37 C  747  ASP MET GLU LYS ALA GLU SER LEU GLN VAL THR ARG GLY          
SEQRES  38 C  747  ASP PHE LEU ALA SER LEU GLU ASN ASP ILE LYS PRO ALA          
SEQRES  39 C  747  PHE GLY THR ASN GLN GLU ASP TYR ALA SER TYR ILE MET          
SEQRES  40 C  747  ASN GLY ILE ILE LYS TRP GLY ASP PRO VAL THR ARG VAL          
SEQRES  41 C  747  LEU ASP ASP GLY GLU LEU LEU VAL GLN GLN THR LYS ASN          
SEQRES  42 C  747  SER ASP ARG THR PRO LEU VAL SER VAL LEU LEU GLU GLY          
SEQRES  43 C  747  PRO PRO HIS SER GLY LYS THR ALA LEU ALA ALA LYS ILE          
SEQRES  44 C  747  ALA GLU GLU SER ASN PHE PRO PHE ILE LYS ILE CYS SER          
SEQRES  45 C  747  PRO ASP LYS MET ILE GLY PHE SER GLU THR ALA LYS CYS          
SEQRES  46 C  747  GLN ALA MET LYS LYS ILE PHE ASP ASP ALA TYR LYS SER          
SEQRES  47 C  747  GLN LEU SER CYS VAL VAL VAL ASP ASP ILE GLU ARG LEU          
SEQRES  48 C  747  LEU ASP TYR VAL PRO ILE GLY PRO ARG PHE SER ASN LEU          
SEQRES  49 C  747  VAL LEU GLN ALA LEU LEU VAL LEU LEU LYS LYS ALA PRO          
SEQRES  50 C  747  PRO GLN GLY ARG LYS LEU LEU ILE ILE GLY THR THR SER          
SEQRES  51 C  747  ARG LYS ASP VAL LEU GLN GLU MET GLU MET LEU ASN ALA          
SEQRES  52 C  747  PHE SER THR THR ILE HIS VAL PRO ASN ILE ALA THR GLY          
SEQRES  53 C  747  GLU GLN LEU LEU GLU ALA LEU GLU LEU LEU GLY ASN PHE          
SEQRES  54 C  747  LYS ASP LYS GLU ARG THR THR ILE ALA GLN GLN VAL LYS          
SEQRES  55 C  747  GLY LYS LYS VAL TRP ILE GLY ILE LYS LYS LEU LEU MET          
SEQRES  56 C  747  LEU ILE GLU MET SER LEU GLN MET ASP PRO GLU TYR ARG          
SEQRES  57 C  747  VAL ARG LYS PHE LEU ALA LEU LEU ARG GLU GLU GLY ALA          
SEQRES  58 C  747  SER PRO LEU ASP PHE ASP                                      
SEQRES   1 D  747  GLY ALA HIS MET ALA GLY ARG SER MET GLN ALA ALA ARG          
SEQRES   2 D  747  CYS PRO THR ASP GLU LEU SER LEU SER ASN CYS ALA VAL          
SEQRES   3 D  747  VAL SER GLU LYS ASP TYR GLN SER GLY GLN HIS VAL ILE          
SEQRES   4 D  747  VAL ARG THR SER PRO ASN HIS LYS TYR ILE PHE THR LEU          
SEQRES   5 D  747  ARG THR HIS PRO SER VAL VAL PRO GLY SER VAL ALA PHE          
SEQRES   6 D  747  SER LEU PRO GLN ARG LYS TRP ALA GLY LEU SER ILE GLY          
SEQRES   7 D  747  GLN GLU ILE GLU VAL ALA LEU TYR SER PHE ASP LYS ALA          
SEQRES   8 D  747  LYS GLN CYS ILE GLY THR MET THR ILE GLU ILE ASP PHE          
SEQRES   9 D  747  LEU GLN LYS LYS ASN ILE ASP SER ASN PRO TYR ASP THR          
SEQRES  10 D  747  ASP LYS MET ALA ALA GLU PHE ILE GLN GLN PHE ASN ASN          
SEQRES  11 D  747  GLN ALA PHE SER VAL GLY GLN GLN LEU VAL PHE SER PHE          
SEQRES  12 D  747  ASN ASP LYS LEU PHE GLY LEU LEU VAL LYS ASP ILE GLU          
SEQRES  13 D  747  ALA MET ASP PRO SER ILE LEU LYS GLY GLU PRO ALA SER          
SEQRES  14 D  747  GLY LYS ARG GLN LYS ILE GLU VAL GLY LEU VAL VAL GLY          
SEQRES  15 D  747  ASN SER GLN VAL ALA PHE GLU LYS ALA GLU ASN SER SER          
SEQRES  16 D  747  LEU ASN LEU ILE GLY LYS ALA LYS THR LYS GLU ASN ARG          
SEQRES  17 D  747  GLN SER ILE ILE ASN PRO ASP TRP ASN PHE GLU LYS MET          
SEQRES  18 D  747  GLY ILE GLY GLY LEU ASP LYS GLU PHE SER ASP ILE PHE          
SEQRES  19 D  747  ARG ARG ALA PHE ALA SER ARG VAL PHE PRO PRO GLU ILE          
SEQRES  20 D  747  VAL GLU GLN MET GLY CYS LYS HIS VAL LYS GLY ILE LEU          
SEQRES  21 D  747  LEU TYR GLY PRO PRO GLY CYS GLY LYS THR LEU LEU ALA          
SEQRES  22 D  747  ARG GLN ILE GLY LYS MET LEU ASN ALA ARG GLU PRO LYS          
SEQRES  23 D  747  VAL VAL ASN GLY PRO GLU ILE LEU ASN LYS TYR VAL GLY          
SEQRES  24 D  747  GLU SER GLU ALA ASN ILE ARG LYS LEU PHE ALA ASP ALA          
SEQRES  25 D  747  GLU GLU GLU GLN ARG ARG LEU GLY ALA ASN SER GLY LEU          
SEQRES  26 D  747  HIS ILE ILE ILE PHE ASP GLU ILE ASP ALA ILE CYS LYS          
SEQRES  27 D  747  GLN ARG GLY SER MET ALA GLY SER THR GLY VAL HIS ASP          
SEQRES  28 D  747  THR VAL VAL ASN GLN LEU LEU SER LYS ILE ASP GLY VAL          
SEQRES  29 D  747  GLU GLN LEU ASN ASN ILE LEU VAL ILE GLY MET THR ASN          
SEQRES  30 D  747  ARG PRO ASP LEU ILE ASP GLU ALA LEU LEU ARG PRO GLY          
SEQRES  31 D  747  ARG LEU GLU VAL LYS MET GLU ILE GLY LEU PRO ASP GLU          
SEQRES  32 D  747  LYS GLY ARG LEU GLN ILE LEU HIS ILE HIS THR ALA ARG          
SEQRES  33 D  747  MET ARG GLY HIS GLN LEU LEU SER ALA ASP VAL ASP ILE          
SEQRES  34 D  747  LYS GLU LEU ALA VAL GLU THR LYS ASN PHE SER GLY ALA          
SEQRES  35 D  747  GLU LEU GLU GLY LEU VAL ARG ALA ALA GLN SER THR ALA          
SEQRES  36 D  747  MET ASN ARG HIS ILE LYS ALA SER THR LYS VAL GLU VAL          
SEQRES  37 D  747  ASP MET GLU LYS ALA GLU SER LEU GLN VAL THR ARG GLY          
SEQRES  38 D  747  ASP PHE LEU ALA SER LEU GLU ASN ASP ILE LYS PRO ALA          
SEQRES  39 D  747  PHE GLY THR ASN GLN GLU ASP TYR ALA SER TYR ILE MET          
SEQRES  40 D  747  ASN GLY ILE ILE LYS TRP GLY ASP PRO VAL THR ARG VAL          
SEQRES  41 D  747  LEU ASP ASP GLY GLU LEU LEU VAL GLN GLN THR LYS ASN          
SEQRES  42 D  747  SER ASP ARG THR PRO LEU VAL SER VAL LEU LEU GLU GLY          
SEQRES  43 D  747  PRO PRO HIS SER GLY LYS THR ALA LEU ALA ALA LYS ILE          
SEQRES  44 D  747  ALA GLU GLU SER ASN PHE PRO PHE ILE LYS ILE CYS SER          
SEQRES  45 D  747  PRO ASP LYS MET ILE GLY PHE SER GLU THR ALA LYS CYS          
SEQRES  46 D  747  GLN ALA MET LYS LYS ILE PHE ASP ASP ALA TYR LYS SER          
SEQRES  47 D  747  GLN LEU SER CYS VAL VAL VAL ASP ASP ILE GLU ARG LEU          
SEQRES  48 D  747  LEU ASP TYR VAL PRO ILE GLY PRO ARG PHE SER ASN LEU          
SEQRES  49 D  747  VAL LEU GLN ALA LEU LEU VAL LEU LEU LYS LYS ALA PRO          
SEQRES  50 D  747  PRO GLN GLY ARG LYS LEU LEU ILE ILE GLY THR THR SER          
SEQRES  51 D  747  ARG LYS ASP VAL LEU GLN GLU MET GLU MET LEU ASN ALA          
SEQRES  52 D  747  PHE SER THR THR ILE HIS VAL PRO ASN ILE ALA THR GLY          
SEQRES  53 D  747  GLU GLN LEU LEU GLU ALA LEU GLU LEU LEU GLY ASN PHE          
SEQRES  54 D  747  LYS ASP LYS GLU ARG THR THR ILE ALA GLN GLN VAL LYS          
SEQRES  55 D  747  GLY LYS LYS VAL TRP ILE GLY ILE LYS LYS LEU LEU MET          
SEQRES  56 D  747  LEU ILE GLU MET SER LEU GLN MET ASP PRO GLU TYR ARG          
SEQRES  57 D  747  VAL ARG LYS PHE LEU ALA LEU LEU ARG GLU GLU GLY ALA          
SEQRES  58 D  747  SER PRO LEU ASP PHE ASP                                      
SEQRES   1 E  747  GLY ALA HIS MET ALA GLY ARG SER MET GLN ALA ALA ARG          
SEQRES   2 E  747  CYS PRO THR ASP GLU LEU SER LEU SER ASN CYS ALA VAL          
SEQRES   3 E  747  VAL SER GLU LYS ASP TYR GLN SER GLY GLN HIS VAL ILE          
SEQRES   4 E  747  VAL ARG THR SER PRO ASN HIS LYS TYR ILE PHE THR LEU          
SEQRES   5 E  747  ARG THR HIS PRO SER VAL VAL PRO GLY SER VAL ALA PHE          
SEQRES   6 E  747  SER LEU PRO GLN ARG LYS TRP ALA GLY LEU SER ILE GLY          
SEQRES   7 E  747  GLN GLU ILE GLU VAL ALA LEU TYR SER PHE ASP LYS ALA          
SEQRES   8 E  747  LYS GLN CYS ILE GLY THR MET THR ILE GLU ILE ASP PHE          
SEQRES   9 E  747  LEU GLN LYS LYS ASN ILE ASP SER ASN PRO TYR ASP THR          
SEQRES  10 E  747  ASP LYS MET ALA ALA GLU PHE ILE GLN GLN PHE ASN ASN          
SEQRES  11 E  747  GLN ALA PHE SER VAL GLY GLN GLN LEU VAL PHE SER PHE          
SEQRES  12 E  747  ASN ASP LYS LEU PHE GLY LEU LEU VAL LYS ASP ILE GLU          
SEQRES  13 E  747  ALA MET ASP PRO SER ILE LEU LYS GLY GLU PRO ALA SER          
SEQRES  14 E  747  GLY LYS ARG GLN LYS ILE GLU VAL GLY LEU VAL VAL GLY          
SEQRES  15 E  747  ASN SER GLN VAL ALA PHE GLU LYS ALA GLU ASN SER SER          
SEQRES  16 E  747  LEU ASN LEU ILE GLY LYS ALA LYS THR LYS GLU ASN ARG          
SEQRES  17 E  747  GLN SER ILE ILE ASN PRO ASP TRP ASN PHE GLU LYS MET          
SEQRES  18 E  747  GLY ILE GLY GLY LEU ASP LYS GLU PHE SER ASP ILE PHE          
SEQRES  19 E  747  ARG ARG ALA PHE ALA SER ARG VAL PHE PRO PRO GLU ILE          
SEQRES  20 E  747  VAL GLU GLN MET GLY CYS LYS HIS VAL LYS GLY ILE LEU          
SEQRES  21 E  747  LEU TYR GLY PRO PRO GLY CYS GLY LYS THR LEU LEU ALA          
SEQRES  22 E  747  ARG GLN ILE GLY LYS MET LEU ASN ALA ARG GLU PRO LYS          
SEQRES  23 E  747  VAL VAL ASN GLY PRO GLU ILE LEU ASN LYS TYR VAL GLY          
SEQRES  24 E  747  GLU SER GLU ALA ASN ILE ARG LYS LEU PHE ALA ASP ALA          
SEQRES  25 E  747  GLU GLU GLU GLN ARG ARG LEU GLY ALA ASN SER GLY LEU          
SEQRES  26 E  747  HIS ILE ILE ILE PHE ASP GLU ILE ASP ALA ILE CYS LYS          
SEQRES  27 E  747  GLN ARG GLY SER MET ALA GLY SER THR GLY VAL HIS ASP          
SEQRES  28 E  747  THR VAL VAL ASN GLN LEU LEU SER LYS ILE ASP GLY VAL          
SEQRES  29 E  747  GLU GLN LEU ASN ASN ILE LEU VAL ILE GLY MET THR ASN          
SEQRES  30 E  747  ARG PRO ASP LEU ILE ASP GLU ALA LEU LEU ARG PRO GLY          
SEQRES  31 E  747  ARG LEU GLU VAL LYS MET GLU ILE GLY LEU PRO ASP GLU          
SEQRES  32 E  747  LYS GLY ARG LEU GLN ILE LEU HIS ILE HIS THR ALA ARG          
SEQRES  33 E  747  MET ARG GLY HIS GLN LEU LEU SER ALA ASP VAL ASP ILE          
SEQRES  34 E  747  LYS GLU LEU ALA VAL GLU THR LYS ASN PHE SER GLY ALA          
SEQRES  35 E  747  GLU LEU GLU GLY LEU VAL ARG ALA ALA GLN SER THR ALA          
SEQRES  36 E  747  MET ASN ARG HIS ILE LYS ALA SER THR LYS VAL GLU VAL          
SEQRES  37 E  747  ASP MET GLU LYS ALA GLU SER LEU GLN VAL THR ARG GLY          
SEQRES  38 E  747  ASP PHE LEU ALA SER LEU GLU ASN ASP ILE LYS PRO ALA          
SEQRES  39 E  747  PHE GLY THR ASN GLN GLU ASP TYR ALA SER TYR ILE MET          
SEQRES  40 E  747  ASN GLY ILE ILE LYS TRP GLY ASP PRO VAL THR ARG VAL          
SEQRES  41 E  747  LEU ASP ASP GLY GLU LEU LEU VAL GLN GLN THR LYS ASN          
SEQRES  42 E  747  SER ASP ARG THR PRO LEU VAL SER VAL LEU LEU GLU GLY          
SEQRES  43 E  747  PRO PRO HIS SER GLY LYS THR ALA LEU ALA ALA LYS ILE          
SEQRES  44 E  747  ALA GLU GLU SER ASN PHE PRO PHE ILE LYS ILE CYS SER          
SEQRES  45 E  747  PRO ASP LYS MET ILE GLY PHE SER GLU THR ALA LYS CYS          
SEQRES  46 E  747  GLN ALA MET LYS LYS ILE PHE ASP ASP ALA TYR LYS SER          
SEQRES  47 E  747  GLN LEU SER CYS VAL VAL VAL ASP ASP ILE GLU ARG LEU          
SEQRES  48 E  747  LEU ASP TYR VAL PRO ILE GLY PRO ARG PHE SER ASN LEU          
SEQRES  49 E  747  VAL LEU GLN ALA LEU LEU VAL LEU LEU LYS LYS ALA PRO          
SEQRES  50 E  747  PRO GLN GLY ARG LYS LEU LEU ILE ILE GLY THR THR SER          
SEQRES  51 E  747  ARG LYS ASP VAL LEU GLN GLU MET GLU MET LEU ASN ALA          
SEQRES  52 E  747  PHE SER THR THR ILE HIS VAL PRO ASN ILE ALA THR GLY          
SEQRES  53 E  747  GLU GLN LEU LEU GLU ALA LEU GLU LEU LEU GLY ASN PHE          
SEQRES  54 E  747  LYS ASP LYS GLU ARG THR THR ILE ALA GLN GLN VAL LYS          
SEQRES  55 E  747  GLY LYS LYS VAL TRP ILE GLY ILE LYS LYS LEU LEU MET          
SEQRES  56 E  747  LEU ILE GLU MET SER LEU GLN MET ASP PRO GLU TYR ARG          
SEQRES  57 E  747  VAL ARG LYS PHE LEU ALA LEU LEU ARG GLU GLU GLY ALA          
SEQRES  58 E  747  SER PRO LEU ASP PHE ASP                                      
SEQRES   1 F  747  GLY ALA HIS MET ALA GLY ARG SER MET GLN ALA ALA ARG          
SEQRES   2 F  747  CYS PRO THR ASP GLU LEU SER LEU SER ASN CYS ALA VAL          
SEQRES   3 F  747  VAL SER GLU LYS ASP TYR GLN SER GLY GLN HIS VAL ILE          
SEQRES   4 F  747  VAL ARG THR SER PRO ASN HIS LYS TYR ILE PHE THR LEU          
SEQRES   5 F  747  ARG THR HIS PRO SER VAL VAL PRO GLY SER VAL ALA PHE          
SEQRES   6 F  747  SER LEU PRO GLN ARG LYS TRP ALA GLY LEU SER ILE GLY          
SEQRES   7 F  747  GLN GLU ILE GLU VAL ALA LEU TYR SER PHE ASP LYS ALA          
SEQRES   8 F  747  LYS GLN CYS ILE GLY THR MET THR ILE GLU ILE ASP PHE          
SEQRES   9 F  747  LEU GLN LYS LYS ASN ILE ASP SER ASN PRO TYR ASP THR          
SEQRES  10 F  747  ASP LYS MET ALA ALA GLU PHE ILE GLN GLN PHE ASN ASN          
SEQRES  11 F  747  GLN ALA PHE SER VAL GLY GLN GLN LEU VAL PHE SER PHE          
SEQRES  12 F  747  ASN ASP LYS LEU PHE GLY LEU LEU VAL LYS ASP ILE GLU          
SEQRES  13 F  747  ALA MET ASP PRO SER ILE LEU LYS GLY GLU PRO ALA SER          
SEQRES  14 F  747  GLY LYS ARG GLN LYS ILE GLU VAL GLY LEU VAL VAL GLY          
SEQRES  15 F  747  ASN SER GLN VAL ALA PHE GLU LYS ALA GLU ASN SER SER          
SEQRES  16 F  747  LEU ASN LEU ILE GLY LYS ALA LYS THR LYS GLU ASN ARG          
SEQRES  17 F  747  GLN SER ILE ILE ASN PRO ASP TRP ASN PHE GLU LYS MET          
SEQRES  18 F  747  GLY ILE GLY GLY LEU ASP LYS GLU PHE SER ASP ILE PHE          
SEQRES  19 F  747  ARG ARG ALA PHE ALA SER ARG VAL PHE PRO PRO GLU ILE          
SEQRES  20 F  747  VAL GLU GLN MET GLY CYS LYS HIS VAL LYS GLY ILE LEU          
SEQRES  21 F  747  LEU TYR GLY PRO PRO GLY CYS GLY LYS THR LEU LEU ALA          
SEQRES  22 F  747  ARG GLN ILE GLY LYS MET LEU ASN ALA ARG GLU PRO LYS          
SEQRES  23 F  747  VAL VAL ASN GLY PRO GLU ILE LEU ASN LYS TYR VAL GLY          
SEQRES  24 F  747  GLU SER GLU ALA ASN ILE ARG LYS LEU PHE ALA ASP ALA          
SEQRES  25 F  747  GLU GLU GLU GLN ARG ARG LEU GLY ALA ASN SER GLY LEU          
SEQRES  26 F  747  HIS ILE ILE ILE PHE ASP GLU ILE ASP ALA ILE CYS LYS          
SEQRES  27 F  747  GLN ARG GLY SER MET ALA GLY SER THR GLY VAL HIS ASP          
SEQRES  28 F  747  THR VAL VAL ASN GLN LEU LEU SER LYS ILE ASP GLY VAL          
SEQRES  29 F  747  GLU GLN LEU ASN ASN ILE LEU VAL ILE GLY MET THR ASN          
SEQRES  30 F  747  ARG PRO ASP LEU ILE ASP GLU ALA LEU LEU ARG PRO GLY          
SEQRES  31 F  747  ARG LEU GLU VAL LYS MET GLU ILE GLY LEU PRO ASP GLU          
SEQRES  32 F  747  LYS GLY ARG LEU GLN ILE LEU HIS ILE HIS THR ALA ARG          
SEQRES  33 F  747  MET ARG GLY HIS GLN LEU LEU SER ALA ASP VAL ASP ILE          
SEQRES  34 F  747  LYS GLU LEU ALA VAL GLU THR LYS ASN PHE SER GLY ALA          
SEQRES  35 F  747  GLU LEU GLU GLY LEU VAL ARG ALA ALA GLN SER THR ALA          
SEQRES  36 F  747  MET ASN ARG HIS ILE LYS ALA SER THR LYS VAL GLU VAL          
SEQRES  37 F  747  ASP MET GLU LYS ALA GLU SER LEU GLN VAL THR ARG GLY          
SEQRES  38 F  747  ASP PHE LEU ALA SER LEU GLU ASN ASP ILE LYS PRO ALA          
SEQRES  39 F  747  PHE GLY THR ASN GLN GLU ASP TYR ALA SER TYR ILE MET          
SEQRES  40 F  747  ASN GLY ILE ILE LYS TRP GLY ASP PRO VAL THR ARG VAL          
SEQRES  41 F  747  LEU ASP ASP GLY GLU LEU LEU VAL GLN GLN THR LYS ASN          
SEQRES  42 F  747  SER ASP ARG THR PRO LEU VAL SER VAL LEU LEU GLU GLY          
SEQRES  43 F  747  PRO PRO HIS SER GLY LYS THR ALA LEU ALA ALA LYS ILE          
SEQRES  44 F  747  ALA GLU GLU SER ASN PHE PRO PHE ILE LYS ILE CYS SER          
SEQRES  45 F  747  PRO ASP LYS MET ILE GLY PHE SER GLU THR ALA LYS CYS          
SEQRES  46 F  747  GLN ALA MET LYS LYS ILE PHE ASP ASP ALA TYR LYS SER          
SEQRES  47 F  747  GLN LEU SER CYS VAL VAL VAL ASP ASP ILE GLU ARG LEU          
SEQRES  48 F  747  LEU ASP TYR VAL PRO ILE GLY PRO ARG PHE SER ASN LEU          
SEQRES  49 F  747  VAL LEU GLN ALA LEU LEU VAL LEU LEU LYS LYS ALA PRO          
SEQRES  50 F  747  PRO GLN GLY ARG LYS LEU LEU ILE ILE GLY THR THR SER          
SEQRES  51 F  747  ARG LYS ASP VAL LEU GLN GLU MET GLU MET LEU ASN ALA          
SEQRES  52 F  747  PHE SER THR THR ILE HIS VAL PRO ASN ILE ALA THR GLY          
SEQRES  53 F  747  GLU GLN LEU LEU GLU ALA LEU GLU LEU LEU GLY ASN PHE          
SEQRES  54 F  747  LYS ASP LYS GLU ARG THR THR ILE ALA GLN GLN VAL LYS          
SEQRES  55 F  747  GLY LYS LYS VAL TRP ILE GLY ILE LYS LYS LEU LEU MET          
SEQRES  56 F  747  LEU ILE GLU MET SER LEU GLN MET ASP PRO GLU TYR ARG          
SEQRES  57 F  747  VAL ARG LYS PHE LEU ALA LEU LEU ARG GLU GLU GLY ALA          
SEQRES  58 F  747  SER PRO LEU ASP PHE ASP                                      
SEQRES   1 G  297  GLY SER MET ASP THR SER GLY LYS GLN ALA GLU ALA MET          
SEQRES   2 G  297  ALA LEU LEU ALA GLU ALA GLU ARG LYS VAL LYS ASN SER          
SEQRES   3 G  297  GLN SER PHE PHE SER GLY LEU PHE GLY GLY SER SER LYS          
SEQRES   4 G  297  ILE GLU GLU ALA CYS GLU ILE TYR ALA ARG ALA ALA ASN          
SEQRES   5 G  297  MET PHE LYS MET ALA LYS ASN TRP SER ALA ALA GLY ASN          
SEQRES   6 G  297  ALA PHE CYS GLN ALA ALA GLN LEU HIS LEU GLN LEU GLN          
SEQRES   7 G  297  SER LYS HIS ASP ALA ALA THR CYS PHE VAL ASP ALA GLY          
SEQRES   8 G  297  ASN ALA PHE LYS LYS ALA ASP PRO GLN GLU ALA ILE ASN          
SEQRES   9 G  297  CYS LEU MET ARG ALA ILE GLU ILE TYR THR ASP MET GLY          
SEQRES  10 G  297  ARG PHE THR ILE ALA ALA LYS HIS HIS ILE SER ILE ALA          
SEQRES  11 G  297  GLU ILE TYR GLU THR GLU LEU VAL ASP VAL GLU LYS ALA          
SEQRES  12 G  297  ILE ALA HIS TYR GLU GLN SER ALA ASP TYR TYR LYS GLY          
SEQRES  13 G  297  GLU GLU SER ASN SER SER ALA ASN LYS CYS LEU LEU LYS          
SEQRES  14 G  297  VAL ALA GLY TYR ALA ALA GLN LEU GLU GLN TYR GLN LYS          
SEQRES  15 G  297  ALA ILE ASP ILE TYR GLU GLN VAL GLY THR SER ALA MET          
SEQRES  16 G  297  ASP SER PRO LEU LEU LYS TYR SER ALA LYS ASP TYR PHE          
SEQRES  17 G  297  PHE LYS ALA ALA LEU CYS HIS PHE CYS ILE ASP MET LEU          
SEQRES  18 G  297  ASN ALA LYS LEU ALA VAL GLN LYS TYR GLU GLU LEU PHE          
SEQRES  19 G  297  PRO ALA PHE SER ASP SER ARG GLU CYS LYS LEU MET LYS          
SEQRES  20 G  297  LYS LEU LEU GLU ALA HIS GLU GLU GLN ASN VAL ASP SER          
SEQRES  21 G  297  TYR THR GLU SER VAL LYS GLU TYR ASP SER ILE SER ARG          
SEQRES  22 G  297  LEU ASP GLN TRP LEU THR THR MET LEU LEU ARG ILE LYS          
SEQRES  23 G  297  LYS THR ILE GLN GLY ASP GLU GLU ASP LEU ARG                  
SEQRES   1 H  297  GLY SER MET ASP THR SER GLY LYS GLN ALA GLU ALA MET          
SEQRES   2 H  297  ALA LEU LEU ALA GLU ALA GLU ARG LYS VAL LYS ASN SER          
SEQRES   3 H  297  GLN SER PHE PHE SER GLY LEU PHE GLY GLY SER SER LYS          
SEQRES   4 H  297  ILE GLU GLU ALA CYS GLU ILE TYR ALA ARG ALA ALA ASN          
SEQRES   5 H  297  MET PHE LYS MET ALA LYS ASN TRP SER ALA ALA GLY ASN          
SEQRES   6 H  297  ALA PHE CYS GLN ALA ALA GLN LEU HIS LEU GLN LEU GLN          
SEQRES   7 H  297  SER LYS HIS ASP ALA ALA THR CYS PHE VAL ASP ALA GLY          
SEQRES   8 H  297  ASN ALA PHE LYS LYS ALA ASP PRO GLN GLU ALA ILE ASN          
SEQRES   9 H  297  CYS LEU MET ARG ALA ILE GLU ILE TYR THR ASP MET GLY          
SEQRES  10 H  297  ARG PHE THR ILE ALA ALA LYS HIS HIS ILE SER ILE ALA          
SEQRES  11 H  297  GLU ILE TYR GLU THR GLU LEU VAL ASP VAL GLU LYS ALA          
SEQRES  12 H  297  ILE ALA HIS TYR GLU GLN SER ALA ASP TYR TYR LYS GLY          
SEQRES  13 H  297  GLU GLU SER ASN SER SER ALA ASN LYS CYS LEU LEU LYS          
SEQRES  14 H  297  VAL ALA GLY TYR ALA ALA GLN LEU GLU GLN TYR GLN LYS          
SEQRES  15 H  297  ALA ILE ASP ILE TYR GLU GLN VAL GLY THR SER ALA MET          
SEQRES  16 H  297  ASP SER PRO LEU LEU LYS TYR SER ALA LYS ASP TYR PHE          
SEQRES  17 H  297  PHE LYS ALA ALA LEU CYS HIS PHE CYS ILE ASP MET LEU          
SEQRES  18 H  297  ASN ALA LYS LEU ALA VAL GLN LYS TYR GLU GLU LEU PHE          
SEQRES  19 H  297  PRO ALA PHE SER ASP SER ARG GLU CYS LYS LEU MET LYS          
SEQRES  20 H  297  LYS LEU LEU GLU ALA HIS GLU GLU GLN ASN VAL ASP SER          
SEQRES  21 H  297  TYR THR GLU SER VAL LYS GLU TYR ASP SER ILE SER ARG          
SEQRES  22 H  297  LEU ASP GLN TRP LEU THR THR MET LEU LEU ARG ILE LYS          
SEQRES  23 H  297  LYS THR ILE GLN GLY ASP GLU GLU ASP LEU ARG                  
SEQRES   1 I  297  GLY SER MET ASP THR SER GLY LYS GLN ALA GLU ALA MET          
SEQRES   2 I  297  ALA LEU LEU ALA GLU ALA GLU ARG LYS VAL LYS ASN SER          
SEQRES   3 I  297  GLN SER PHE PHE SER GLY LEU PHE GLY GLY SER SER LYS          
SEQRES   4 I  297  ILE GLU GLU ALA CYS GLU ILE TYR ALA ARG ALA ALA ASN          
SEQRES   5 I  297  MET PHE LYS MET ALA LYS ASN TRP SER ALA ALA GLY ASN          
SEQRES   6 I  297  ALA PHE CYS GLN ALA ALA GLN LEU HIS LEU GLN LEU GLN          
SEQRES   7 I  297  SER LYS HIS ASP ALA ALA THR CYS PHE VAL ASP ALA GLY          
SEQRES   8 I  297  ASN ALA PHE LYS LYS ALA ASP PRO GLN GLU ALA ILE ASN          
SEQRES   9 I  297  CYS LEU MET ARG ALA ILE GLU ILE TYR THR ASP MET GLY          
SEQRES  10 I  297  ARG PHE THR ILE ALA ALA LYS HIS HIS ILE SER ILE ALA          
SEQRES  11 I  297  GLU ILE TYR GLU THR GLU LEU VAL ASP VAL GLU LYS ALA          
SEQRES  12 I  297  ILE ALA HIS TYR GLU GLN SER ALA ASP TYR TYR LYS GLY          
SEQRES  13 I  297  GLU GLU SER ASN SER SER ALA ASN LYS CYS LEU LEU LYS          
SEQRES  14 I  297  VAL ALA GLY TYR ALA ALA GLN LEU GLU GLN TYR GLN LYS          
SEQRES  15 I  297  ALA ILE ASP ILE TYR GLU GLN VAL GLY THR SER ALA MET          
SEQRES  16 I  297  ASP SER PRO LEU LEU LYS TYR SER ALA LYS ASP TYR PHE          
SEQRES  17 I  297  PHE LYS ALA ALA LEU CYS HIS PHE CYS ILE ASP MET LEU          
SEQRES  18 I  297  ASN ALA LYS LEU ALA VAL GLN LYS TYR GLU GLU LEU PHE          
SEQRES  19 I  297  PRO ALA PHE SER ASP SER ARG GLU CYS LYS LEU MET LYS          
SEQRES  20 I  297  LYS LEU LEU GLU ALA HIS GLU GLU GLN ASN VAL ASP SER          
SEQRES  21 I  297  TYR THR GLU SER VAL LYS GLU TYR ASP SER ILE SER ARG          
SEQRES  22 I  297  LEU ASP GLN TRP LEU THR THR MET LEU LEU ARG ILE LYS          
SEQRES  23 I  297  LYS THR ILE GLN GLY ASP GLU GLU ASP LEU ARG                  
SEQRES   1 J  297  GLY SER MET ASP THR SER GLY LYS GLN ALA GLU ALA MET          
SEQRES   2 J  297  ALA LEU LEU ALA GLU ALA GLU ARG LYS VAL LYS ASN SER          
SEQRES   3 J  297  GLN SER PHE PHE SER GLY LEU PHE GLY GLY SER SER LYS          
SEQRES   4 J  297  ILE GLU GLU ALA CYS GLU ILE TYR ALA ARG ALA ALA ASN          
SEQRES   5 J  297  MET PHE LYS MET ALA LYS ASN TRP SER ALA ALA GLY ASN          
SEQRES   6 J  297  ALA PHE CYS GLN ALA ALA GLN LEU HIS LEU GLN LEU GLN          
SEQRES   7 J  297  SER LYS HIS ASP ALA ALA THR CYS PHE VAL ASP ALA GLY          
SEQRES   8 J  297  ASN ALA PHE LYS LYS ALA ASP PRO GLN GLU ALA ILE ASN          
SEQRES   9 J  297  CYS LEU MET ARG ALA ILE GLU ILE TYR THR ASP MET GLY          
SEQRES  10 J  297  ARG PHE THR ILE ALA ALA LYS HIS HIS ILE SER ILE ALA          
SEQRES  11 J  297  GLU ILE TYR GLU THR GLU LEU VAL ASP VAL GLU LYS ALA          
SEQRES  12 J  297  ILE ALA HIS TYR GLU GLN SER ALA ASP TYR TYR LYS GLY          
SEQRES  13 J  297  GLU GLU SER ASN SER SER ALA ASN LYS CYS LEU LEU LYS          
SEQRES  14 J  297  VAL ALA GLY TYR ALA ALA GLN LEU GLU GLN TYR GLN LYS          
SEQRES  15 J  297  ALA ILE ASP ILE TYR GLU GLN VAL GLY THR SER ALA MET          
SEQRES  16 J  297  ASP SER PRO LEU LEU LYS TYR SER ALA LYS ASP TYR PHE          
SEQRES  17 J  297  PHE LYS ALA ALA LEU CYS HIS PHE CYS ILE ASP MET LEU          
SEQRES  18 J  297  ASN ALA LYS LEU ALA VAL GLN LYS TYR GLU GLU LEU PHE          
SEQRES  19 J  297  PRO ALA PHE SER ASP SER ARG GLU CYS LYS LEU MET LYS          
SEQRES  20 J  297  LYS LEU LEU GLU ALA HIS GLU GLU GLN ASN VAL ASP SER          
SEQRES  21 J  297  TYR THR GLU SER VAL LYS GLU TYR ASP SER ILE SER ARG          
SEQRES  22 J  297  LEU ASP GLN TRP LEU THR THR MET LEU LEU ARG ILE LYS          
SEQRES  23 J  297  LYS THR ILE GLN GLY ASP GLU GLU ASP LEU ARG                  
SEQRES   1 K   63  GLY SER ASN ARG ARG LEU GLN GLN THR GLN ALA GLN VAL          
SEQRES   2 K   63  ASP GLU VAL VAL ASP ILE MET ARG VAL ASN VAL ASP LYS          
SEQRES   3 K   63  VAL LEU GLU ARG ASP GLN LYS LEU SER GLU LEU ASP ASP          
SEQRES   4 K   63  ARG ALA ASP ALA LEU GLN ALA GLY ALA SER GLN PHE GLU          
SEQRES   5 K   63  THR SER ALA ALA LYS LEU LYS ARG LYS TYR TRP                  
SEQRES   1 L   67  MET ALA LEU SER GLU ILE GLU THR ARG HIS SER GLU ILE          
SEQRES   2 L   67  ILE LYS LEU GLU ASN SER ILE ARG GLU LEU HIS ASP MET          
SEQRES   3 L   67  PHE MET ASP MET ALA MET LEU VAL GLU SER GLN GLY GLU          
SEQRES   4 L   67  MET ILE ASP ARG ILE GLU TYR ASN VAL GLU HIS ALA VAL          
SEQRES   5 L   67  ASP TYR VAL GLU ARG ALA VAL SER ASP THR LYS LYS ALA          
SEQRES   6 L   67  VAL LYS                                                      
SEQRES   1 M  188  ARG ALA ASP GLN LEU ALA ASP GLU SER LEU GLU SER THR          
SEQRES   2 M  188  ARG ARG MET LEU GLN LEU VAL GLU GLU SER LYS ASP ALA          
SEQRES   3 M  188  GLY ILE ARG THR LEU VAL MET LEU ASP GLU GLN GLY GLU          
SEQRES   4 M  188  GLN LEU ASP ARG VAL GLU GLU GLY MET ASN HIS ILE ASN          
SEQRES   5 M  188  GLN ASP MET LYS GLU ALA GLU LYS ASN LEU LYS ASP LEU          
SEQRES   6 M  188  GLY LYS PHE CYS GLY LEU CYS VAL CYS PRO CYS ASN LYS          
SEQRES   7 M  188  LEU LYS SER SER ASP ALA TYR LYS LYS ALA TRP GLY ASN          
SEQRES   8 M  188  ASN GLN ASP GLY VAL VAL ALA SER GLN PRO ALA ARG VAL          
SEQRES   9 M  188  VAL ASP GLU ARG GLU GLN MET ALA ILE SER GLY GLY PHE          
SEQRES  10 M  188  ILE ARG ARG VAL THR ASN ASP ALA ARG GLU ASN GLU MET          
SEQRES  11 M  188  ASP GLU ASN LEU GLU GLN VAL SER GLY ILE ILE GLY ASN          
SEQRES  12 M  188  LEU ARG HIS MET ALA LEU ASP MET GLY ASN GLU ILE ASP          
SEQRES  13 M  188  THR GLN ASN ARG GLN ILE ASP ARG ILE MET GLU LYS ALA          
SEQRES  14 M  188  ASP SER ASN LYS THR ARG ILE ASP GLU ALA ASN GLN ARG          
SEQRES  15 M  188  ALA THR LYS MET LEU GLY                                      
HELIX    1   1 SER A   63  LYS A   68  1                                   6    
HELIX    2   2 THR A  114  PHE A  125  1                                  12    
HELIX    3   3 LEU A  223  PHE A  240  1                                  18    
HELIX    4   4 PRO A  242  GLY A  249  1                                   8    
HELIX    5   5 GLY A  265  ASN A  278  1                                  14    
HELIX    6   6 GLY A  296  LEU A  316  1                                  21    
HELIX    7   7 ASP A  348  ASP A  359  1                                  12    
HELIX    8   8 ASP A  380  ARG A  385  1                                   6    
HELIX    9   9 ASP A  399  HIS A  417  1                                  19    
HELIX   10  10 ASP A  425  THR A  433  1                                   9    
HELIX   11  11 SER A  437  ILE A  457  1                                  21    
HELIX   12  12 PHE A  480  LYS A  489  1                                  10    
HELIX   13  13 ASP A  498  MET A  504  1                                   7    
HELIX   14  14 GLY A  511  SER A  531  1                                  21    
HELIX   15  15 GLY A  548  ASN A  561  1                                  14    
HELIX   16  16 SER A  569  ILE A  574  1                                   6    
HELIX   17  17 SER A  577  SER A  595  1                                  19    
HELIX   18  18 ASP A  604  ASP A  610  1                                   7    
HELIX   19  19 SER A  619  LYS A  632  1                                  14    
HELIX   20  20 ARG A  648  MET A  655  1                                   8    
HELIX   21  21 GLU A  656  PHE A  661  1                                   6    
HELIX   22  22 THR A  672  GLY A  684  1                                  13    
HELIX   23  23 LYS A  687  LYS A  699  1                                  13    
HELIX   24  24 GLY A  706  GLN A  719  1                                  14    
HELIX   25  25 ASP A  721  GLU A  736  1                                  16    
HELIX   26  26 GLU B   15  SER B   19  5                                   5    
HELIX   27  27 SER B   63  LYS B   68  1                                   6    
HELIX   28  28 ASP B   86  GLN B   90  1                                   5    
HELIX   29  29 GLN B  103  ILE B  107  5                                   5    
HELIX   30  30 THR B  114  PHE B  125  1                                  12    
HELIX   31  31 ASP B  224  PHE B  240  1                                  17    
HELIX   32  32 GLU B  243  GLY B  249  1                                   7    
HELIX   33  33 GLY B  265  ASN B  278  1                                  14    
HELIX   34  34 GLU B  297  GLY B  317  1                                  21    
HELIX   35  35 ASP B  348  ASP B  359  1                                  12    
HELIX   36  36 ASP B  380  ARG B  385  1                                   6    
HELIX   37  37 ASP B  399  HIS B  417  1                                  19    
HELIX   38  38 ASP B  425  THR B  433  1                                   9    
HELIX   39  39 SER B  437  ILE B  457  1                                  21    
HELIX   40  40 PHE B  480  ILE B  488  1                                   9    
HELIX   41  41 GLN B  496  TYR B  502  1                                   7    
HELIX   42  42 GLY B  511  SER B  531  1                                  21    
HELIX   43  43 GLY B  548  ASN B  561  1                                  14    
HELIX   44  44 SER B  577  SER B  595  1                                  19    
HELIX   45  45 ASP B  604  LEU B  609  1                                   6    
HELIX   46  46 SER B  619  LYS B  632  1                                  14    
HELIX   47  47 ARG B  648  GLU B  656  1                                   9    
HELIX   48  48 GLU B  656  PHE B  661  1                                   6    
HELIX   49  49 GLY B  673  GLY B  684  1                                  12    
HELIX   50  50 LYS B  687  GLN B  697  1                                  11    
HELIX   51  51 ILE B  707  GLN B  719  1                                  13    
HELIX   52  52 TYR B  724  ARG B  734  1                                  11    
HELIX   53  53 SER C   63  LYS C   68  1                                   6    
HELIX   54  54 THR C  114  GLN C  123  1                                  10    
HELIX   55  55 ASP C  224  PHE C  240  1                                  17    
HELIX   56  56 GLU C  243  GLY C  249  1                                   7    
HELIX   57  57 GLY C  265  ASN C  278  1                                  14    
HELIX   58  58 GLU C  297  GLY C  317  1                                  21    
HELIX   59  59 GLU C  329  CYS C  334  1                                   6    
HELIX   60  60 ASP C  348  ASP C  359  1                                  12    
HELIX   61  61 ASP C  380  ARG C  385  1                                   6    
HELIX   62  62 ASP C  399  HIS C  417  1                                  19    
HELIX   63  63 ASP C  425  THR C  433  1                                   9    
HELIX   64  64 SER C  437  ILE C  457  1                                  21    
HELIX   65  65 PHE C  480  LYS C  489  1                                  10    
HELIX   66  66 ASP C  498  ILE C  503  1                                   6    
HELIX   67  67 GLY C  511  SER C  531  1                                  21    
HELIX   68  68 GLY C  548  ASN C  561  1                                  14    
HELIX   69  69 SER C  577  SER C  595  1                                  19    
HELIX   70  70 ASP C  604  ASP C  610  1                                   7    
HELIX   71  71 SER C  619  LYS C  632  1                                  14    
HELIX   72  72 ARG C  648  MET C  655  1                                   8    
HELIX   73  73 GLU C  656  PHE C  661  1                                   6    
HELIX   74  74 GLY C  673  GLY C  684  1                                  12    
HELIX   75  75 LYS C  687  LYS C  699  1                                  13    
HELIX   76  76 GLY C  706  MET C  720  1                                  15    
HELIX   77  77 ARG C  725  GLY C  737  1                                  13    
HELIX   78  78 GLU D   15  SER D   19  5                                   5    
HELIX   79  79 SER D   63  ALA D   70  1                                   8    
HELIX   80  80 THR D  114  ILE D  122  1                                   9    
HELIX   81  81 LEU D  223  PHE D  240  1                                  18    
HELIX   82  82 PRO D  242  GLY D  249  1                                   8    
HELIX   83  83 GLY D  265  ASN D  278  1                                  14    
HELIX   84  84 VAL D  295  GLY D  317  1                                  23    
HELIX   85  85 THR D  349  LYS D  357  1                                   9    
HELIX   86  86 ASP D  380  ARG D  385  1                                   6    
HELIX   87  87 ASP D  399  HIS D  417  1                                  19    
HELIX   88  88 ASP D  425  THR D  433  1                                   9    
HELIX   89  89 SER D  437  ILE D  457  1                                  21    
HELIX   90  90 LEU D  481  ILE D  488  1                                   8    
HELIX   91  91 ASP D  498  TYR D  502  5                                   5    
HELIX   92  92 GLY D  511  SER D  531  1                                  21    
HELIX   93  93 GLY D  548  GLU D  559  1                                  12    
HELIX   94  94 SER D  569  ILE D  574  1                                   6    
HELIX   95  95 SER D  577  TYR D  593  1                                  17    
HELIX   96  96 ASP D  604  ASP D  610  1                                   7    
HELIX   97  97 SER D  619  LYS D  632  1                                  14    
HELIX   98  98 ARG D  648  GLU D  656  1                                   9    
HELIX   99  99 MET D  657  PHE D  661  5                                   5    
HELIX  100 100 GLY D  673  GLY D  684  1                                  12    
HELIX  101 101 LYS D  687  LYS D  699  1                                  13    
HELIX  102 102 GLY D  706  LEU D  718  1                                  13    
HELIX  103 103 TYR D  724  GLU D  736  1                                  13    
HELIX  104 104 GLU E   15  SER E   19  5                                   5    
HELIX  105 105 SER E   63  GLY E   71  1                                   9    
HELIX  106 106 GLN E  103  ILE E  107  5                                   5    
HELIX  107 107 THR E  114  ASN E  126  1                                  13    
HELIX  108 108 ASP E  224  PHE E  240  1                                  17    
HELIX  109 109 GLU E  243  GLY E  249  1                                   7    
HELIX  110 110 GLY E  265  ASN E  278  1                                  14    
HELIX  111 111 GLU E  297  GLY E  317  1                                  21    
HELIX  112 112 ASP E  348  ASP E  359  1                                  12    
HELIX  113 113 ASP E  380  ARG E  385  1                                   6    
HELIX  114 114 ASP E  399  HIS E  417  1                                  19    
HELIX  115 115 ASP E  425  THR E  433  1                                   9    
HELIX  116 116 SER E  437  ILE E  457  1                                  21    
HELIX  117 117 PHE E  480  ILE E  488  1                                   9    
HELIX  118 118 ASP E  498  TYR E  502  5                                   5    
HELIX  119 119 GLY E  511  ASN E  530  1                                  20    
HELIX  120 120 GLY E  548  ASN E  561  1                                  14    
HELIX  121 121 SER E  569  ILE E  574  1                                   6    
HELIX  122 122 SER E  577  LYS E  594  1                                  18    
HELIX  123 123 ASP E  604  ASP E  610  1                                   7    
HELIX  124 124 SER E  619  LYS E  632  1                                  14    
HELIX  125 125 ARG E  648  MET E  655  1                                   8    
HELIX  126 126 GLU E  656  PHE E  661  1                                   6    
HELIX  127 127 THR E  672  GLY E  684  1                                  13    
HELIX  128 128 LYS E  687  LYS E  699  1                                  13    
HELIX  129 129 GLY E  706  GLN E  719  1                                  14    
HELIX  130 130 ASP E  721  GLY E  737  1                                  17    
HELIX  131 131 GLU F   15  SER F   19  5                                   5    
HELIX  132 132 SER F   63  GLY F   71  1                                   9    
HELIX  133 133 THR F  114  GLN F  123  1                                  10    
HELIX  134 134 ASP F  224  PHE F  240  1                                  17    
HELIX  135 135 PRO F  242  GLY F  249  1                                   8    
HELIX  136 136 GLY F  265  ASN F  278  1                                  14    
HELIX  137 137 GLU F  297  LEU F  316  1                                  20    
HELIX  138 138 ASP F  348  ASP F  359  1                                  12    
HELIX  139 139 ASP F  380  ARG F  385  1                                   6    
HELIX  140 140 ASP F  399  HIS F  417  1                                  19    
HELIX  141 141 ASP F  425  THR F  433  1                                   9    
HELIX  142 142 SER F  437  ILE F  457  1                                  21    
HELIX  143 143 ASP F  498  ILE F  503  1                                   6    
HELIX  144 144 GLY F  511  SER F  531  1                                  21    
HELIX  145 145 GLY F  548  ASN F  561  1                                  14    
HELIX  146 146 SER F  577  SER F  595  1                                  19    
HELIX  147 147 ASP F  604  ASP F  610  1                                   7    
HELIX  148 148 SER F  619  LYS F  632  1                                  14    
HELIX  149 149 ARG F  648  MET F  655  1                                   8    
HELIX  150 150 GLU F  656  PHE F  661  1                                   6    
HELIX  151 151 GLY F  673  GLY F  684  1                                  12    
HELIX  152 152 LYS F  687  LYS F  699  1                                  13    
HELIX  153 153 GLY F  706  GLN F  719  1                                  14    
HELIX  154 154 GLU F  723  GLU F  736  1                                  14    
HELIX  155 155 GLU G    9  VAL G   21  1                                  13    
HELIX  156 156 GLY G   34  ALA G   55  1                                  22    
HELIX  157 157 TRP G   58  GLN G   74  1                                  17    
HELIX  158 158 SER G   77  LYS G   94  1                                  18    
HELIX  159 159 ALA G  100  GLY G  115  1                                  16    
HELIX  160 160 ARG G  116  GLU G  134  1                                  19    
HELIX  161 161 ASP G  137  GLU G  155  1                                  19    
HELIX  162 162 SER G  157  LEU G  175  1                                  19    
HELIX  163 163 TYR G  178  SER G  191  1                                  14    
HELIX  164 164 SER G  201  CYS G  212  1                                  12    
HELIX  165 165 LEU G  219  LYS G  227  1                                   9    
HELIX  166 166 ALA G  234  ARG G  239  5                                   6    
HELIX  167 167 GLU G  240  GLU G  253  1                                  14    
HELIX  168 168 ASP G  257  SER G  270  1                                  14    
HELIX  169 169 ASP G  273  GLU G  292  1                                  20    
HELIX  170 170 GLU H    9  VAL H   21  1                                  13    
HELIX  171 171 GLY H   34  ALA H   55  1                                  22    
HELIX  172 172 TRP H   58  GLN H   74  1                                  17    
HELIX  173 173 SER H   77  LYS H   94  1                                  18    
HELIX  174 174 GLU H   99  MET H  114  1                                  16    
HELIX  175 175 ARG H  116  GLU H  134  1                                  19    
HELIX  176 176 ASP H  137  GLU H  155  1                                  19    
HELIX  177 177 SER H  157  LEU H  175  1                                  19    
HELIX  178 178 TYR H  178  SER H  191  1                                  14    
HELIX  179 179 SER H  201  CYS H  212  1                                  12    
HELIX  180 180 LEU H  219  TYR H  228  1                                  10    
HELIX  181 181 SER H  236  ARG H  239  5                                   4    
HELIX  182 182 GLU H  240  GLU H  253  1                                  14    
HELIX  183 183 SER H  258  SER H  270  1                                  13    
HELIX  184 184 ASP H  273  GLU H  292  1                                  20    
HELIX  185 185 GLU I    9  ARG I   19  1                                  11    
HELIX  186 186 SER I   36  LYS I   53  1                                  18    
HELIX  187 187 TRP I   58  GLN I   74  1                                  17    
HELIX  188 188 SER I   77  ALA I   95  1                                  19    
HELIX  189 189 GLU I   99  GLY I  115  1                                  17    
HELIX  190 190 ARG I  116  GLU I  134  1                                  19    
HELIX  191 191 ASP I  137  GLU I  155  1                                  19    
HELIX  192 192 SER I  157  GLU I  176  1                                  20    
HELIX  193 193 TYR I  178  ASP I  194  1                                  17    
HELIX  194 194 SER I  201  CYS I  212  1                                  12    
HELIX  195 195 LEU I  219  TYR I  228  1                                  10    
HELIX  196 196 PHE I  235  ARG I  239  5                                   5    
HELIX  197 197 GLU I  240  GLU I  253  1                                  14    
HELIX  198 198 ASP I  257  SER I  270  1                                  14    
HELIX  199 199 ASP I  273  GLU I  292  1                                  20    
HELIX  200 200 GLU J    9  LYS J   20  1                                  12    
HELIX  201 201 GLN J   25  SER J   29  5                                   5    
HELIX  202 202 GLY J   34  ALA J   55  1                                  22    
HELIX  203 203 TRP J   58  GLN J   76  1                                  19    
HELIX  204 204 SER J   77  ALA J   95  1                                  19    
HELIX  205 205 GLU J   99  GLY J  115  1                                  17    
HELIX  206 206 ARG J  116  GLU J  134  1                                  19    
HELIX  207 207 ASP J  137  GLU J  155  1                                  19    
HELIX  208 208 SER J  157  ALA J  173  1                                  17    
HELIX  209 209 TYR J  178  ASP J  194  1                                  17    
HELIX  210 210 LEU J  198  CYS J  212  1                                  15    
HELIX  211 211 LEU J  219  TYR J  228  1                                  10    
HELIX  212 212 PHE J  235  ARG J  239  5                                   5    
HELIX  213 213 GLU J  240  GLU J  252  1                                  13    
HELIX  214 214 SER J  258  SER J  270  1                                  13    
HELIX  215 215 ASP J  273  GLU J  292  1                                  20    
HELIX  216 216 ARG K   30  TRP K   89  1                                  60    
HELIX  217 217 LEU L  192  ALA L  254  1                                  63    
HELIX  218 218 ALA M   18  ARG M   59  1                                  42    
HELIX  219 219 VAL M   60  LYS M   83  1                                  24    
HELIX  220 220 ARG M  142  ARG M  198  1                                  57    
SHEET    1   A 7 ARG A   4  ARG A  10  0                                        
SHEET    2   A 7 SER A  59  PHE A  62  1  O  VAL A  60   N  ALA A   9           
SHEET    3   A 7 ALA A  22  VAL A  24 -1  N  VAL A  23   O  ALA A  61           
SHEET    4   A 7 LYS A  44  THR A  51  1  O  THR A  48   N  ALA A  22           
SHEET    5   A 7 HIS A  34  ARG A  38 -1  N  VAL A  37   O  TYR A  45           
SHEET    6   A 7 GLU A  77  LEU A  82 -1  O  ALA A  81   N  ILE A  36           
SHEET    7   A 7 ARG A   4  ARG A  10 -1  N  MET A   6   O  ILE A  78           
SHEET    1   B 3 ASP A 100  PHE A 101  0                                        
SHEET    2   B 3 LYS A 143  ALA A 154 -1  O  GLY A 146   N  ASP A 100           
SHEET    3   B 3 GLN A 135  LEU A 136 -1  N  LEU A 136   O  LEU A 147           
SHEET    1   C 5 GLN A 128  SER A 131  0                                        
SHEET    2   C 5 VAL A 174  PHE A 185 -1  O  GLY A 175   N  PHE A 130           
SHEET    3   C 5 CYS A  91  ILE A  97  1  N  ILE A  97   O  ALA A 184           
SHEET    4   C 5 LYS A 143  ALA A 154 -1  O  GLU A 153   N  GLY A  93           
SHEET    5   C 5 SER A 139  PHE A 140 -1  N  PHE A 140   O  LYS A 143           
SHEET    1   D 2 PRO A 111  ASP A 113  0                                        
SHEET    2   D 2 ASN A 194  ILE A 196  1  O  ASN A 194   N  TYR A 112           
SHEET    1   E 5 VAL A 284  VAL A 285  0                                        
SHEET    2   E 5 HIS A 323  ASP A 328  1  O  ILE A 326   N  VAL A 284           
SHEET    3   E 5 ILE A 367  MET A 372  1  O  LEU A 368   N  HIS A 323           
SHEET    4   E 5 GLY A 255  TYR A 259  1  N  LEU A 258   O  GLY A 371           
SHEET    5   E 5 VAL A 391  GLU A 394  1  O  VAL A 391   N  LEU A 257           
SHEET    1   F 5 PHE A 564  ILE A 567  0                                        
SHEET    2   F 5 LEU A 597  VAL A 602  1  O  VAL A 601   N  LYS A 566           
SHEET    3   F 5 LYS A 639  THR A 646  1  O  LEU A 641   N  VAL A 600           
SHEET    4   F 5 LEU A 536  GLU A 542  1  N  VAL A 537   O  ILE A 642           
SHEET    5   F 5 THR A 663  HIS A 666  1  O  ILE A 665   N  LEU A 540           
SHEET    1   G 3 SER B  59  PHE B  62  0                                        
SHEET    2   G 3 ARG B   4  ARG B  10  1  N  ALA B   9   O  VAL B  60           
SHEET    3   G 3 GLU B  77  VAL B  80 -1  O  ILE B  78   N  MET B   6           
SHEET    1   H 4 CYS B  21  VAL B  24  0                                        
SHEET    2   H 4 HIS B  43  THR B  51  1  O  THR B  48   N  ALA B  22           
SHEET    3   H 4 HIS B  34  SER B  40 -1  N  SER B  40   O  HIS B  43           
SHEET    4   H 4 LEU B  82  TYR B  83 -1  O  TYR B  83   N  HIS B  34           
SHEET    1   I 5 GLN B 128  SER B 131  0                                        
SHEET    2   I 5 VAL B 174  LYS B 187 -1  O  GLY B 175   N  PHE B 130           
SHEET    3   I 5 CYS B  91  ILE B  99  1  N  ILE B  97   O  ALA B 184           
SHEET    4   I 5 LYS B 143  GLU B 153 -1  O  GLU B 153   N  GLY B  93           
SHEET    5   I 5 GLN B 135  PHE B 140 -1  N  PHE B 140   O  LYS B 143           
SHEET    1   J 2 PRO B 111  ASP B 113  0                                        
SHEET    2   J 2 ASN B 194  ILE B 196  1  O  ASN B 194   N  TYR B 112           
SHEET    1   K 5 VAL B 284  ASN B 286  0                                        
SHEET    2   K 5 HIS B 323  ASP B 328  1  O  ILE B 326   N  VAL B 284           
SHEET    3   K 5 ILE B 367  THR B 373  1  O  LEU B 368   N  HIS B 323           
SHEET    4   K 5 GLY B 255  TYR B 259  1  N  LEU B 258   O  GLY B 371           
SHEET    5   K 5 VAL B 391  GLU B 394  1  O  MET B 393   N  LEU B 257           
SHEET    1   L 5 PHE B 564  CYS B 568  0                                        
SHEET    2   L 5 LEU B 597  VAL B 602  1  O  CYS B 599   N  PHE B 564           
SHEET    3   L 5 LYS B 639  THR B 646  1  O  ILE B 643   N  VAL B 602           
SHEET    4   L 5 LEU B 536  GLU B 542  1  N  VAL B 539   O  GLY B 644           
SHEET    5   L 5 THR B 663  HIS B 666  1  O  ILE B 665   N  LEU B 540           
SHEET    1   M 2 ILE B 670  THR B 672  0                                        
SHEET    2   M 2 LYS B 702  ILE B 705 -1  O  ILE B 705   N  ILE B 670           
SHEET    1   N 5 HIS C  43  THR C  48  0                                        
SHEET    2   N 5 HIS C  34  SER C  40 -1  N  VAL C  37   O  TYR C  45           
SHEET    3   N 5 GLU C  77  LEU C  82 -1  O  ALA C  81   N  ILE C  36           
SHEET    4   N 5 ARG C   4  ARG C  10 -1  N  MET C   6   O  ILE C  78           
SHEET    5   N 5 SER C  59  PHE C  62  1  O  VAL C  60   N  ALA C   9           
SHEET    1   O 5 GLN C 128  SER C 131  0                                        
SHEET    2   O 5 VAL C 174  LYS C 187 -1  O  VAL C 177   N  GLN C 128           
SHEET    3   O 5 CYS C  91  ILE C  99  1  N  ILE C  97   O  ALA C 184           
SHEET    4   O 5 LEU C 144  ALA C 154 -1  O  GLU C 153   N  GLY C  93           
SHEET    5   O 5 GLN C 135  SER C 139 -1  N  LEU C 136   O  LEU C 147           
SHEET    1   P 5 GLN C 128  SER C 131  0                                        
SHEET    2   P 5 VAL C 174  LYS C 187 -1  O  VAL C 177   N  GLN C 128           
SHEET    3   P 5 CYS C  91  ILE C  99  1  N  ILE C  97   O  ALA C 184           
SHEET    4   P 5 LEU C 144  ALA C 154 -1  O  GLU C 153   N  GLY C  93           
SHEET    5   P 5 GLN C 170  ILE C 172 -1  O  GLN C 170   N  ALA C 154           
SHEET    1   Q 2 PRO C 111  ASP C 113  0                                        
SHEET    2   Q 2 ASN C 194  ILE C 196  1  O  ILE C 196   N  TYR C 112           
SHEET    1   R 5 VAL C 284  ASN C 286  0                                        
SHEET    2   R 5 HIS C 323  ASP C 328  1  O  ILE C 326   N  VAL C 284           
SHEET    3   R 5 ILE C 367  THR C 373  1  O  ILE C 370   N  PHE C 327           
SHEET    4   R 5 GLY C 255  TYR C 259  1  N  LEU C 258   O  GLY C 371           
SHEET    5   R 5 VAL C 391  GLU C 394  1  O  MET C 393   N  TYR C 259           
SHEET    1   S 5 PHE C 564  CYS C 568  0                                        
SHEET    2   S 5 LEU C 597  VAL C 602  1  O  VAL C 601   N  CYS C 568           
SHEET    3   S 5 LYS C 639  THR C 646  1  O  ILE C 643   N  VAL C 602           
SHEET    4   S 5 LEU C 536  GLU C 542  1  N  LEU C 541   O  GLY C 644           
SHEET    5   S 5 THR C 663  HIS C 666  1  O  ILE C 665   N  GLU C 542           
SHEET    1   T 2 ILE C 670  THR C 672  0                                        
SHEET    2   T 2 LYS C 702  ILE C 705 -1  O  ILE C 705   N  ILE C 670           
SHEET    1   U 6 CYS D  21  ALA D  22  0                                        
SHEET    2   U 6 LYS D  44  LEU D  49  1  O  THR D  48   N  ALA D  22           
SHEET    3   U 6 HIS D  34  ARG D  38 -1  N  VAL D  37   O  TYR D  45           
SHEET    4   U 6 GLU D  77  LEU D  82 -1  O  ALA D  81   N  ILE D  36           
SHEET    5   U 6 ARG D   4  ARG D  10 -1  N  MET D   6   O  ILE D  78           
SHEET    6   U 6 VAL D  60  PHE D  62  1  O  PHE D  62   N  ALA D   9           
SHEET    1   V 3 GLN D 135  LEU D 136  0                                        
SHEET    2   V 3 LYS D 143  ALA D 154 -1  O  LEU D 147   N  LEU D 136           
SHEET    3   V 3 GLN D 170  LYS D 171 -1  O  GLN D 170   N  ALA D 154           
SHEET    1   W 4 SER D 139  PHE D 140  0                                        
SHEET    2   W 4 LYS D 143  ALA D 154 -1  O  LYS D 143   N  PHE D 140           
SHEET    3   W 4 ILE D  92  PHE D 101 -1  N  GLY D  93   O  GLU D 153           
SHEET    4   W 4 GLN D 182  LYS D 187  1  O  ALA D 184   N  ILE D  97           
SHEET    1   X 2 PRO D 111  ASP D 113  0                                        
SHEET    2   X 2 ASN D 194  ILE D 196  1  O  ASN D 194   N  TYR D 112           
SHEET    1   Y 2 ALA D 129  SER D 131  0                                        
SHEET    2   Y 2 VAL D 174  LEU D 176 -1  O  GLY D 175   N  PHE D 130           
SHEET    1   Z 5 VAL D 284  ASN D 286  0                                        
SHEET    2   Z 5 ILE D 324  ASP D 328  1  O  ILE D 326   N  VAL D 284           
SHEET    3   Z 5 LEU D 368  THR D 373  1  O  ILE D 370   N  PHE D 327           
SHEET    4   Z 5 GLY D 255  TYR D 259  1  N  LEU D 258   O  GLY D 371           
SHEET    5   Z 5 VAL D 391  GLU D 394  1  O  MET D 393   N  LEU D 257           
SHEET    1  AA 5 PHE D 564  CYS D 568  0                                        
SHEET    2  AA 5 LEU D 597  VAL D 602  1  O  VAL D 601   N  CYS D 568           
SHEET    3  AA 5 LYS D 639  THR D 645  1  O  ILE D 643   N  VAL D 602           
SHEET    4  AA 5 LEU D 536  GLU D 542  1  N  VAL D 537   O  ILE D 642           
SHEET    5  AA 5 THR D 663  HIS D 666  1  O  ILE D 665   N  LEU D 540           
SHEET    1  AB 2 ILE D 670  THR D 672  0                                        
SHEET    2  AB 2 LYS D 702  ILE D 705 -1  O  VAL D 703   N  ALA D 671           
SHEET    1  AC 7 ARG E   4  ARG E  10  0                                        
SHEET    2  AC 7 SER E  59  PHE E  62  1  O  VAL E  60   N  ALA E   9           
SHEET    3  AC 7 ALA E  22  VAL E  24 -1  N  VAL E  23   O  ALA E  61           
SHEET    4  AC 7 LYS E  44  THR E  51  1  O  THR E  48   N  ALA E  22           
SHEET    5  AC 7 HIS E  34  ARG E  38 -1  N  VAL E  35   O  PHE E  47           
SHEET    6  AC 7 GLU E  77  TYR E  83 -1  O  TYR E  83   N  HIS E  34           
SHEET    7  AC 7 ARG E   4  ARG E  10 -1  N  MET E   6   O  ILE E  78           
SHEET    1  AD 5 GLN E 128  SER E 131  0                                        
SHEET    2  AD 5 VAL E 174  LYS E 187 -1  O  VAL E 177   N  GLN E 128           
SHEET    3  AD 5 CYS E  91  PHE E 101  1  N  ILE E  97   O  ALA E 184           
SHEET    4  AD 5 LEU E 144  ALA E 154 -1  O  GLY E 146   N  ASP E 100           
SHEET    5  AD 5 GLN E 135  SER E 139 -1  N  LEU E 136   O  LEU E 147           
SHEET    1  AE 2 PRO E 111  ASP E 113  0                                        
SHEET    2  AE 2 ASN E 194  ILE E 196  1  O  ASN E 194   N  TYR E 112           
SHEET    1  AF 5 VAL E 284  ASN E 286  0                                        
SHEET    2  AF 5 HIS E 323  ASP E 328  1  O  ILE E 326   N  VAL E 284           
SHEET    3  AF 5 ILE E 367  THR E 373  1  O  LEU E 368   N  HIS E 323           
SHEET    4  AF 5 GLY E 255  TYR E 259  1  N  LEU E 258   O  GLY E 371           
SHEET    5  AF 5 VAL E 391  GLU E 394  1  O  MET E 393   N  LEU E 257           
SHEET    1  AG 5 PHE E 564  LYS E 566  0                                        
SHEET    2  AG 5 SER E 598  ASP E 603  1  O  CYS E 599   N  PHE E 564           
SHEET    3  AG 5 LEU E 640  THR E 646  1  O  ILE E 643   N  VAL E 602           
SHEET    4  AG 5 LEU E 536  GLU E 542  1  N  VAL E 539   O  ILE E 642           
SHEET    5  AG 5 THR E 663  HIS E 666  1  O  ILE E 665   N  GLU E 542           
SHEET    1  AH 5 LYS F  44  THR F  48  0                                        
SHEET    2  AH 5 HIS F  34  ARG F  38 -1  N  VAL F  35   O  PHE F  47           
SHEET    3  AH 5 GLU F  77  LEU F  82 -1  O  ALA F  81   N  ILE F  36           
SHEET    4  AH 5 ARG F   4  ARG F  10 -1  N  MET F   6   O  ILE F  78           
SHEET    5  AH 5 VAL F  60  PHE F  62  1  O  VAL F  60   N  ALA F   9           
SHEET    1  AI 5 GLN F 128  SER F 131  0                                        
SHEET    2  AI 5 VAL F 174  LYS F 187 -1  O  VAL F 177   N  GLN F 128           
SHEET    3  AI 5 CYS F  91  PHE F 101  1  N  ILE F  97   O  ALA F 184           
SHEET    4  AI 5 LEU F 144  ALA F 154 -1  O  GLY F 146   N  ASP F 100           
SHEET    5  AI 5 GLN F 135  SER F 139 -1  N  PHE F 138   O  PHE F 145           
SHEET    1  AJ 2 TYR F 112  ASP F 113  0                                        
SHEET    2  AJ 2 LEU F 195  ILE F 196  1  O  ILE F 196   N  TYR F 112           
SHEET    1  AK 5 VAL F 284  ASN F 286  0                                        
SHEET    2  AK 5 HIS F 323  ASP F 328  1  O  ILE F 326   N  VAL F 284           
SHEET    3  AK 5 ILE F 367  THR F 373  1  O  MET F 372   N  PHE F 327           
SHEET    4  AK 5 GLY F 255  TYR F 259  1  N  LEU F 258   O  GLY F 371           
SHEET    5  AK 5 VAL F 391  GLU F 394  1  O  MET F 393   N  LEU F 257           
SHEET    1  AL 5 PHE F 564  CYS F 568  0                                        
SHEET    2  AL 5 LEU F 597  VAL F 602  1  O  VAL F 601   N  LYS F 566           
SHEET    3  AL 5 LYS F 639  THR F 646  1  O  ILE F 643   N  VAL F 602           
SHEET    4  AL 5 LEU F 536  GLU F 542  1  N  VAL F 539   O  GLY F 644           
SHEET    5  AL 5 ILE F 665  HIS F 666  1  O  ILE F 665   N  GLU F 542           
SHEET    1  AM 2 ILE F 670  THR F 672  0                                        
SHEET    2  AM 2 LYS F 702  ILE F 705 -1  O  ILE F 705   N  ILE F 670           
CISPEP   1 PRO A  262    GLY A  263          0        -4.54                     
CISPEP   2 GLY A  263    CYS A  264          0         3.24                     
CISPEP   3 HIS A  347    ASP A  348          0        -8.01                     
CISPEP   4 PRO A  490    ALA A  491          0       -11.77                     
CISPEP   5 PHE A  492    GLY A  493          0        -6.19                     
CISPEP   6 GLY A  493    THR A  494          0       -11.07                     
CISPEP   7 GLY A  615    PRO A  616          0       -12.74                     
CISPEP   8 GLN A  636    GLY A  637          0       -10.39                     
CISPEP   9 MET B  218    GLY B  219          0        -3.10                     
CISPEP  10 PRO B  241    PRO B  242          0       -27.97                     
CISPEP  11 GLU B  281    PRO B  282          0        -9.68                     
CISPEP  12 GLY B  296    GLU B  297          0        11.23                     
CISPEP  13 ASN B  319    SER B  320          0        -6.58                     
CISPEP  14 GLY B  360    VAL B  361          0        -9.09                     
CISPEP  15 PRO B  490    ALA B  491          0        -4.46                     
CISPEP  16 GLY B  615    PRO B  616          0         9.29                     
CISPEP  17 MET C  218    GLY C  219          0        -2.97                     
CISPEP  18 PRO C  241    PRO C  242          0       -28.37                     
CISPEP  19 GLU C  281    PRO C  282          0       -17.83                     
CISPEP  20 GLY C  296    GLU C  297          0        13.14                     
CISPEP  21 ASN C  319    SER C  320          0        -6.38                     
CISPEP  22 PRO C  490    ALA C  491          0        -5.71                     
CISPEP  23 GLY C  615    PRO C  616          0       -13.01                     
CISPEP  24 MET D  218    GLY D  219          0        -3.07                     
CISPEP  25 PRO D  241    PRO D  242          0       -23.54                     
CISPEP  26 GLU D  281    PRO D  282          0       -20.78                     
CISPEP  27 ASN D  319    SER D  320          0       -12.08                     
CISPEP  28 GLY D  360    VAL D  361          0        -9.11                     
CISPEP  29 GLY D  615    PRO D  616          0         5.33                     
CISPEP  30 MET E  218    GLY E  219          0        -2.96                     
CISPEP  31 PRO E  241    PRO E  242          0       -28.93                     
CISPEP  32 GLU E  281    PRO E  282          0        -9.77                     
CISPEP  33 GLY E  296    GLU E  297          0        11.05                     
CISPEP  34 ASN E  319    SER E  320          0        -7.20                     
CISPEP  35 GLY E  360    VAL E  361          0        -9.18                     
CISPEP  36 PRO E  490    ALA E  491          0        -5.18                     
CISPEP  37 GLY E  615    PRO E  616          0        -7.53                     
CISPEP  38 MET F  218    GLY F  219          0        -2.85                     
CISPEP  39 PRO F  241    PRO F  242          0       -28.89                     
CISPEP  40 GLU F  281    PRO F  282          0        -9.67                     
CISPEP  41 GLY F  296    GLU F  297          0        11.09                     
CISPEP  42 ASN F  319    SER F  320          0        -7.01                     
CISPEP  43 GLY F  360    VAL F  361          0        -8.93                     
CISPEP  44 PRO F  545    HIS F  546          0         0.33                     
CISPEP  45 GLY F  615    PRO F  616          0         4.14                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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