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Database: PDB
Entry: 3JAV
LinkDB: 3JAV
Original site: 3JAV 
HEADER    TRANSPORT PROTEIN                       30-JUN-15   3JAV              
TITLE     STRUCTURE OF FULL-LENGTH IP3R1 CHANNEL IN THE APO-STATE DETERMINED BY 
TITLE    2 SINGLE PARTICLE CRYO-EM                                              
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1;              
COMPND   3 CHAIN: A, B, C, D;                                                   
COMPND   4 SYNONYM: IP3 RECEPTOR ISOFORM 1, IP-3-R, IP3R 1, INSP3R1, TYPE 1     
COMPND   5 INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR, TYPE 1 INSP3 RECEPTOR         
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;                              
SOURCE   3 ORGANISM_COMMON: RAT;                                                
SOURCE   4 ORGANISM_TAXID: 10116                                                
KEYWDS    INOSITOL 1, 4, 5-TRISPHOSPHATE RECEPTOR, CALCIUM RELEASE CHANNEL,     
KEYWDS   2 CALCIUM SIGNALING, TRANSPORT PROTEIN                                 
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    G.FAN,M.L.BAKER,Z.WANG,M.R.BAKER,P.A.SINYAGOVSKIY,W.CHIU,S.J.LUDTKE,  
AUTHOR   2 I.I.SERYSHEVA                                                        
REVDAT   4   18-JUL-18 3JAV    1       REMARK                                   
REVDAT   3   02-DEC-15 3JAV    1       JRNL                                     
REVDAT   2   21-OCT-15 3JAV    1       JRNL                                     
REVDAT   1   07-OCT-15 3JAV    0                                                
JRNL        AUTH   G.FAN,M.L.BAKER,Z.WANG,M.R.BAKER,P.A.SINYAGOVSKIY,W.CHIU,    
JRNL        AUTH 2 S.J.LUDTKE,I.I.SERYSHEVA                                     
JRNL        TITL   GATING MACHINERY OF INSP3R CHANNELS REVEALED BY ELECTRON     
JRNL        TITL 2 CRYOMICROSCOPY.                                              
JRNL        REF    NATURE                        V. 527   336 2015              
JRNL        REFN                   ISSN 0028-0836                               
JRNL        PMID   26458101                                                     
JRNL        DOI    10.1038/NATURE15249                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.70 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : EMAN, RELION                              
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : 1.620                          
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 4.700                          
REMARK   3   NUMBER OF PARTICLES               : 96106                          
REMARK   3   CTF CORRECTION METHOD             : NULL                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: APPLIED SYMMETRY: C4                                  
REMARK   4                                                                      
REMARK   4 3JAV COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 13-JUL-15.                  
REMARK 100 THE DEPOSITION ID IS D_1000160469.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : VITREOUS ICE (CRYO EM)            
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : INOSITOL 1,4,5-TRISPHOSPHATE      
REMARK 245                                    RECEPTOR, TYPE 1                  
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.40                              
REMARK 245   SAMPLE SUPPORT DETAILS         : 400 MESH COPPER GRIDS WITH THIN   
REMARK 245                                    CARBON SUPPORT                    
REMARK 245   SAMPLE VITRIFICATION DETAILS   : BLOT ONCE FOR 3 SECONDS BEFORE    
REMARK 245                                    PLUNGING INTO LIQUID ETHANE       
REMARK 245                                    (FEI VITROBOT MARK IV).           
REMARK 245   SAMPLE BUFFER                  : 50 MM TRIS-HCL, 0.4% CHAPS, 150   
REMARK 245                                    MM NACL, 1 MM DTT, 1 MM EGTA, 1   
REMARK 245                                    MM EDTA                           
REMARK 245   PH                             : 7.40                              
REMARK 245   SAMPLE DETAILS                 : HOMOTETRAMER                      
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : 01-JAN-14                      
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : 100.00                         
REMARK 245   MICROSCOPE MODEL                  : FEI POLARA 300                 
REMARK 245   DETECTOR TYPE                     : GATAN K2 (4K X 4K)             
REMARK 245   MINIMUM DEFOCUS (NM)              : 600.00                         
REMARK 245   MAXIMUM DEFOCUS (NM)              : 3500.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.00                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 22.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : 23000                          
REMARK 245   CALIBRATED MAGNIFICATION          : 30886                          
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   CD   LYS A  2329     CZ   PHE A  2379              1.05            
REMARK 500   CD   LYS C  2329     CZ   PHE C  2379              1.07            
REMARK 500   CD   LYS B  2329     CZ   PHE B  2379              1.16            
REMARK 500   CD   LYS D  2329     CZ   PHE D  2379              1.16            
REMARK 500   CD   LYS A  2329     CE2  PHE A  2379              1.22            
REMARK 500   CG   LYS A  2329     CE2  PHE A  2379              1.24            
REMARK 500   CG   LYS D  2329     CE2  PHE D  2379              1.28            
REMARK 500   CG   LYS B  2329     CE2  PHE B  2379              1.28            
REMARK 500   O    ILE C  2325     CE   LYS C  2329              1.28            
REMARK 500   CD   LYS C  2329     CE2  PHE C  2379              1.28            
REMARK 500   CD   LYS D  2329     CE2  PHE D  2379              1.29            
REMARK 500   CD   LYS B  2329     CE2  PHE B  2379              1.29            
REMARK 500   O    ILE D  2325     CE   LYS D  2329              1.29            
REMARK 500   O    ILE B  2325     CE   LYS B  2329              1.30            
REMARK 500   CG   LYS C  2329     CE2  PHE C  2379              1.31            
REMARK 500   O    ILE A  2325     CE   LYS A  2329              1.36            
REMARK 500   O    ILE D  2325     NZ   LYS D  2329              1.43            
REMARK 500   O    ILE B  2325     NZ   LYS B  2329              1.43            
REMARK 500   O    ILE C  2325     NZ   LYS C  2329              1.44            
REMARK 500   O    ILE A  2325     NZ   LYS A  2329              1.46            
REMARK 500   CB   LYS D  2329     CE2  PHE D  2379              1.53            
REMARK 500   CB   LYS B  2329     CE2  PHE B  2379              1.53            
REMARK 500   CB   LYS C  2329     CE2  PHE C  2379              1.57            
REMARK 500   CB   LYS A  2329     CE2  PHE A  2379              1.61            
REMARK 500   CB   LYS A  2329     CD2  PHE A  2379              1.61            
REMARK 500   CB   LYS D  2329     CD2  PHE D  2379              1.62            
REMARK 500   CB   LYS B  2329     CD2  PHE B  2379              1.62            
REMARK 500   CB   LYS C  2329     CD2  PHE C  2379              1.64            
REMARK 500   CG   LYS A  2329     CZ   PHE A  2379              1.65            
REMARK 500   CG   LYS B  2329     CZ   PHE B  2379              1.67            
REMARK 500   CG   LYS D  2329     CZ   PHE D  2379              1.68            
REMARK 500   CG   LYS C  2329     CZ   PHE C  2379              1.69            
REMARK 500   O    VAL D  2430     OG   SER D  2433              1.82            
REMARK 500   O    VAL B  2430     OG   SER B  2433              1.82            
REMARK 500   O    VAL A  2430     OG   SER A  2433              1.82            
REMARK 500   O    VAL C  2430     OG   SER C  2433              1.82            
REMARK 500   O    ARG A  2439     N    ILE A  2441              1.84            
REMARK 500   O    ARG C  2439     N    ILE C  2441              1.84            
REMARK 500   O    ARG B  2439     N    ILE B  2441              1.85            
REMARK 500   O    ARG D  2439     N    ILE D  2441              1.86            
REMARK 500   OH   TYR A   387     O    ILE A   432              1.99            
REMARK 500   OH   TYR C   387     O    ILE C   432              1.99            
REMARK 500   OH   TYR D   387     O    ILE D   432              1.99            
REMARK 500   O    GLY B  2374     OG1  THR B  2378              1.99            
REMARK 500   O    GLY D  2374     OG1  THR D  2378              1.99            
REMARK 500   OH   TYR B   387     O    ILE B   432              1.99            
REMARK 500   CD2  PHE A  2586     CZ   PHE B  2586              1.99            
REMARK 500   O    GLY A  2374     OG1  THR A  2378              1.99            
REMARK 500   CD2  PHE C  2586     CZ   PHE D  2586              2.00            
REMARK 500   O    GLY C  2374     OG1  THR C  2378              2.00            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     135 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    TYR A  18   CG    TYR A  18   CD2     0.324                       
REMARK 500    TYR A  18   CG    TYR A  18   CD1     0.324                       
REMARK 500    TYR A  18   CD1   TYR A  18   CE1     0.702                       
REMARK 500    TYR A  18   CE1   TYR A  18   CZ      0.414                       
REMARK 500    TYR A  18   CZ    TYR A  18   CE2     0.417                       
REMARK 500    TYR A  18   CE2   TYR A  18   CD2     0.764                       
REMARK 500    GLU A  20   CB    GLU A  20   CG      0.141                       
REMARK 500    GLU A  20   CG    GLU A  20   CD      1.232                       
REMARK 500    TYR A 117   CG    TYR A 117   CD2     0.333                       
REMARK 500    TYR A 117   CG    TYR A 117   CD1     0.313                       
REMARK 500    TYR A 117   CD1   TYR A 117   CE1     0.622                       
REMARK 500    TYR A 117   CE1   TYR A 117   CZ      0.415                       
REMARK 500    TYR A 117   CZ    TYR A 117   CE2     0.404                       
REMARK 500    TYR A 117   CE2   TYR A 117   CD2     0.654                       
REMARK 500    VAL A 176   CA    VAL A 176   CB      1.635                       
REMARK 500    VAL A 176   CB    VAL A 176   CG1     0.171                       
REMARK 500    VAL A 176   CB    VAL A 176   CG2     0.180                       
REMARK 500    GLU A 285   CA    GLU A 285   C       0.915                       
REMARK 500    PHE A 303   CG    PHE A 303   CD2     0.378                       
REMARK 500    PHE A 303   CG    PHE A 303   CD1     0.365                       
REMARK 500    PHE A 303   CD1   PHE A 303   CE1     0.818                       
REMARK 500    PHE A 303   CE1   PHE A 303   CZ      0.736                       
REMARK 500    PHE A 303   CZ    PHE A 303   CE2     0.753                       
REMARK 500    PHE A 303   CE2   PHE A 303   CD2     0.831                       
REMARK 500    TYR B  18   CG    TYR B  18   CD2     0.324                       
REMARK 500    TYR B  18   CG    TYR B  18   CD1     0.325                       
REMARK 500    TYR B  18   CD1   TYR B  18   CE1     0.701                       
REMARK 500    TYR B  18   CE1   TYR B  18   CZ      0.415                       
REMARK 500    TYR B  18   CZ    TYR B  18   CE2     0.417                       
REMARK 500    TYR B  18   CE2   TYR B  18   CD2     0.762                       
REMARK 500    GLU B  20   CB    GLU B  20   CG      0.140                       
REMARK 500    GLU B  20   CG    GLU B  20   CD      1.233                       
REMARK 500    TYR B 117   CG    TYR B 117   CD2     0.332                       
REMARK 500    TYR B 117   CG    TYR B 117   CD1     0.312                       
REMARK 500    TYR B 117   CD1   TYR B 117   CE1     0.621                       
REMARK 500    TYR B 117   CE1   TYR B 117   CZ      0.415                       
REMARK 500    TYR B 117   CZ    TYR B 117   CE2     0.405                       
REMARK 500    TYR B 117   CE2   TYR B 117   CD2     0.654                       
REMARK 500    VAL B 176   CA    VAL B 176   CB      1.637                       
REMARK 500    VAL B 176   CB    VAL B 176   CG1     0.170                       
REMARK 500    VAL B 176   CB    VAL B 176   CG2     0.178                       
REMARK 500    GLU B 285   CA    GLU B 285   C       0.915                       
REMARK 500    PHE B 303   CG    PHE B 303   CD2     0.378                       
REMARK 500    PHE B 303   CG    PHE B 303   CD1     0.364                       
REMARK 500    PHE B 303   CD1   PHE B 303   CE1     0.817                       
REMARK 500    PHE B 303   CE1   PHE B 303   CZ      0.737                       
REMARK 500    PHE B 303   CZ    PHE B 303   CE2     0.753                       
REMARK 500    PHE B 303   CE2   PHE B 303   CD2     0.829                       
REMARK 500    TYR C  18   CG    TYR C  18   CD2     0.324                       
REMARK 500    TYR C  18   CG    TYR C  18   CD1     0.325                       
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      98 BOND DEVIATIONS.                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    GLU A  20   OE1 -  CD  -  OE2 ANGL. DEV. = -23.1 DEGREES          
REMARK 500    GLU A  20   CG  -  CD  -  OE1 ANGL. DEV. =  13.1 DEGREES          
REMARK 500    PRO A 165   C   -  N   -  CD  ANGL. DEV. = -14.2 DEGREES          
REMARK 500    VAL A 176   CB  -  CA  -  C   ANGL. DEV. =  13.8 DEGREES          
REMARK 500    VAL A 176   CA  -  CB  -  CG1 ANGL. DEV. =  15.2 DEGREES          
REMARK 500    VAL A 176   CA  -  CB  -  CG2 ANGL. DEV. =  16.7 DEGREES          
REMARK 500    GLU A 285   CB  -  CA  -  C   ANGL. DEV. =  15.0 DEGREES          
REMARK 500    GLU A 285   N   -  CA  -  CB  ANGL. DEV. = -15.9 DEGREES          
REMARK 500    GLU A 285   CA  -  C   -  N   ANGL. DEV. =  14.7 DEGREES          
REMARK 500    GLU A 285   O   -  C   -  N   ANGL. DEV. = -19.8 DEGREES          
REMARK 500    PHE A 303   CB  -  CG  -  CD2 ANGL. DEV. =  -4.3 DEGREES          
REMARK 500    ASN A2429   N   -  CA  -  C   ANGL. DEV. =  27.9 DEGREES          
REMARK 500    VAL A2430   CB  -  CA  -  C   ANGL. DEV. = -12.3 DEGREES          
REMARK 500    GLU B  20   OE1 -  CD  -  OE2 ANGL. DEV. = -23.1 DEGREES          
REMARK 500    GLU B  20   CG  -  CD  -  OE1 ANGL. DEV. =  13.1 DEGREES          
REMARK 500    PRO B 165   C   -  N   -  CD  ANGL. DEV. = -14.5 DEGREES          
REMARK 500    VAL B 176   CB  -  CA  -  C   ANGL. DEV. =  13.8 DEGREES          
REMARK 500    VAL B 176   CA  -  CB  -  CG1 ANGL. DEV. =  15.2 DEGREES          
REMARK 500    VAL B 176   CA  -  CB  -  CG2 ANGL. DEV. =  16.7 DEGREES          
REMARK 500    GLU B 285   CB  -  CA  -  C   ANGL. DEV. =  15.1 DEGREES          
REMARK 500    GLU B 285   N   -  CA  -  CB  ANGL. DEV. = -15.8 DEGREES          
REMARK 500    GLU B 285   CA  -  C   -  N   ANGL. DEV. =  14.7 DEGREES          
REMARK 500    GLU B 285   O   -  C   -  N   ANGL. DEV. = -19.7 DEGREES          
REMARK 500    PHE B 303   CB  -  CG  -  CD2 ANGL. DEV. =  -4.3 DEGREES          
REMARK 500    ASN B2429   N   -  CA  -  C   ANGL. DEV. =  27.9 DEGREES          
REMARK 500    VAL B2430   CB  -  CA  -  C   ANGL. DEV. = -12.3 DEGREES          
REMARK 500    GLU C  20   OE1 -  CD  -  OE2 ANGL. DEV. = -23.1 DEGREES          
REMARK 500    GLU C  20   CG  -  CD  -  OE1 ANGL. DEV. =  13.0 DEGREES          
REMARK 500    PRO C 165   C   -  N   -  CD  ANGL. DEV. = -14.2 DEGREES          
REMARK 500    VAL C 176   CB  -  CA  -  C   ANGL. DEV. =  13.8 DEGREES          
REMARK 500    VAL C 176   CA  -  CB  -  CG1 ANGL. DEV. =  15.2 DEGREES          
REMARK 500    VAL C 176   CA  -  CB  -  CG2 ANGL. DEV. =  16.7 DEGREES          
REMARK 500    GLU C 285   CB  -  CA  -  C   ANGL. DEV. =  15.1 DEGREES          
REMARK 500    GLU C 285   N   -  CA  -  CB  ANGL. DEV. = -15.9 DEGREES          
REMARK 500    GLU C 285   CA  -  C   -  N   ANGL. DEV. =  14.7 DEGREES          
REMARK 500    GLU C 285   O   -  C   -  N   ANGL. DEV. = -19.8 DEGREES          
REMARK 500    PHE C 303   CB  -  CG  -  CD2 ANGL. DEV. =  -4.4 DEGREES          
REMARK 500    ASN C2429   N   -  CA  -  C   ANGL. DEV. =  27.9 DEGREES          
REMARK 500    VAL C2430   CB  -  CA  -  C   ANGL. DEV. = -12.3 DEGREES          
REMARK 500    GLU D  20   OE1 -  CD  -  OE2 ANGL. DEV. = -23.1 DEGREES          
REMARK 500    GLU D  20   CG  -  CD  -  OE1 ANGL. DEV. =  13.1 DEGREES          
REMARK 500    PRO D 165   C   -  N   -  CD  ANGL. DEV. = -14.5 DEGREES          
REMARK 500    VAL D 176   CB  -  CA  -  C   ANGL. DEV. =  13.8 DEGREES          
REMARK 500    VAL D 176   CA  -  CB  -  CG1 ANGL. DEV. =  15.2 DEGREES          
REMARK 500    VAL D 176   CA  -  CB  -  CG2 ANGL. DEV. =  16.7 DEGREES          
REMARK 500    GLU D 285   CB  -  CA  -  C   ANGL. DEV. =  15.1 DEGREES          
REMARK 500    GLU D 285   N   -  CA  -  CB  ANGL. DEV. = -15.8 DEGREES          
REMARK 500    GLU D 285   CA  -  C   -  N   ANGL. DEV. =  14.7 DEGREES          
REMARK 500    GLU D 285   O   -  C   -  N   ANGL. DEV. = -19.7 DEGREES          
REMARK 500    PHE D 303   CB  -  CG  -  CD2 ANGL. DEV. =  -4.4 DEGREES          
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      54 ANGLE DEVIATIONS.                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    SER A   6     -154.95     54.64                                   
REMARK 500    SER A   7      119.91     68.75                                   
REMARK 500    PHE A   8      -31.94   -147.51                                   
REMARK 500    LEU A   9     -166.80   -121.15                                   
REMARK 500    ILE A  11      102.48     58.47                                   
REMARK 500    SER A  16     -128.64    -68.57                                   
REMARK 500    GLU A  20       95.21     12.76                                   
REMARK 500    SER A  22      100.82   -175.02                                   
REMARK 500    ARG A  36       91.16    -63.66                                   
REMARK 500    VAL A  38     -158.29   -156.66                                   
REMARK 500    ALA A  43     -152.47     47.26                                   
REMARK 500    ARG A  65      -92.37     56.29                                   
REMARK 500    SER A  67     -107.38   -159.92                                   
REMARK 500    THR A  83     -138.39   -140.46                                   
REMARK 500    LEU A  89      -72.46    -59.96                                   
REMARK 500    ALA A  96      -71.86    -63.13                                   
REMARK 500    GLN A 122      149.30     66.18                                   
REMARK 500    THR A 133      -39.98   -157.63                                   
REMARK 500    ASN A 135     -128.56   -138.43                                   
REMARK 500    LYS A 136      -53.92    141.15                                   
REMARK 500    ARG A 137     -118.91     60.88                                   
REMARK 500    GLU A 143     -179.61   -176.62                                   
REMARK 500    LYS A 144      -84.86    -43.81                                   
REMARK 500    THR A 150     -124.23   -125.66                                   
REMARK 500    TRP A 160      122.51     60.88                                   
REMARK 500    PHE A 166     -123.23   -177.10                                   
REMARK 500    TYR A 167     -100.69     53.15                                   
REMARK 500    LYS A 168      -32.93   -174.13                                   
REMARK 500    ARG A 170       85.02   -161.73                                   
REMARK 500    VAL A 177     -104.35    -98.31                                   
REMARK 500    VAL A 183     -163.81     42.66                                   
REMARK 500    ALA A 189      -59.95   -154.39                                   
REMARK 500    PRO A 192     -137.31    -78.27                                   
REMARK 500    SER A 196      151.90     69.07                                   
REMARK 500    PRO A 204     -131.68    -63.65                                   
REMARK 500    CYS A 206       55.33   -163.54                                   
REMARK 500    ASN A 207     -165.73    -75.90                                   
REMARK 500    GLU A 208     -163.06   -163.53                                   
REMARK 500    SER A 211      -68.84     67.93                                   
REMARK 500    CYS A 214      124.83   -176.99                                   
REMARK 500    TRP A 218     -145.19   -152.98                                   
REMARK 500    LYS A 219      176.07     59.69                                   
REMARK 500    ILE A 220     -150.95   -139.15                                   
REMARK 500    VAL A 221     -139.54   -149.13                                   
REMARK 500    LEU A 222       95.95    -65.93                                   
REMARK 500    MET A 224      155.13     68.03                                   
REMARK 500    ASP A 232      -80.38     51.81                                   
REMARK 500    ILE A 233     -151.98     37.39                                   
REMARK 500    ASP A 238       57.06   -143.37                                   
REMARK 500    VAL A 240     -153.36   -124.42                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     626 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 GLY A   12     ASP A   13                  147.01                    
REMARK 500 LYS A  136     ARG A  137                   32.55                    
REMARK 500 ILE A  163     GLN A  164                 -147.99                    
REMARK 500 LEU A  169     ARG A  170                 -136.94                    
REMARK 500 VAL A  240     ARG A  241                 -142.42                    
REMARK 500 THR A  374     LEU A  375                  145.76                    
REMARK 500 MET A  415     LEU A  416                  142.06                    
REMARK 500 ALA A  431     ILE A  432                 -146.33                    
REMARK 500 GLY B   12     ASP B   13                  147.84                    
REMARK 500 LYS B  136     ARG B  137                   32.71                    
REMARK 500 ILE B  163     GLN B  164                 -148.21                    
REMARK 500 LEU B  169     ARG B  170                 -136.91                    
REMARK 500 VAL B  240     ARG B  241                 -142.31                    
REMARK 500 THR B  374     LEU B  375                  145.79                    
REMARK 500 MET B  415     LEU B  416                  143.27                    
REMARK 500 ALA B  431     ILE B  432                 -147.02                    
REMARK 500 GLY C   12     ASP C   13                  147.12                    
REMARK 500 LYS C  136     ARG C  137                   32.59                    
REMARK 500 ILE C  163     GLN C  164                 -148.14                    
REMARK 500 LEU C  169     ARG C  170                 -136.96                    
REMARK 500 VAL C  240     ARG C  241                 -142.39                    
REMARK 500 THR C  374     LEU C  375                  145.73                    
REMARK 500 MET C  415     LEU C  416                  142.23                    
REMARK 500 ALA C  431     ILE C  432                 -146.32                    
REMARK 500 GLY D   12     ASP D   13                  147.85                    
REMARK 500 LYS D  136     ARG D  137                   32.74                    
REMARK 500 ILE D  163     GLN D  164                 -148.05                    
REMARK 500 LEU D  169     ARG D  170                 -136.83                    
REMARK 500 VAL D  240     ARG D  241                 -142.40                    
REMARK 500 THR D  374     LEU D  375                  145.73                    
REMARK 500 MET D  415     LEU D  416                  143.27                    
REMARK 500 ALA D  431     ILE D  432                 -146.97                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-6369   RELATED DB: EMDB                              
DBREF  3JAV A    1  2750  UNP    P29994   ITPR1_RAT        1   2750             
DBREF  3JAV B    1  2750  UNP    P29994   ITPR1_RAT        1   2750             
DBREF  3JAV C    1  2750  UNP    P29994   ITPR1_RAT        1   2750             
DBREF  3JAV D    1  2750  UNP    P29994   ITPR1_RAT        1   2750             
SEQRES   1 A 2750  MET SER ASP LYS MET SER SER PHE LEU HIS ILE GLY ASP          
SEQRES   2 A 2750  ILE CYS SER LEU TYR ALA GLU GLY SER THR ASN GLY PHE          
SEQRES   3 A 2750  ILE SER THR LEU GLY LEU VAL ASP ASP ARG CYS VAL VAL          
SEQRES   4 A 2750  GLN PRO GLU ALA GLY ASP LEU ASN ASN PRO PRO LYS LYS          
SEQRES   5 A 2750  PHE ARG ASP CYS LEU PHE LYS LEU CYS PRO MET ASN ARG          
SEQRES   6 A 2750  TYR SER ALA GLN LYS GLN PHE TRP LYS ALA ALA LYS PRO          
SEQRES   7 A 2750  GLY ALA ASN SER THR THR ASP ALA VAL LEU LEU ASN LYS          
SEQRES   8 A 2750  LEU HIS HIS ALA ALA ASP LEU GLU LYS LYS GLN ASN GLU          
SEQRES   9 A 2750  THR GLU ASN ARG LYS LEU LEU GLY THR VAL ILE GLN TYR          
SEQRES  10 A 2750  GLY ASN VAL ILE GLN LEU LEU HIS LEU LYS SER ASN LYS          
SEQRES  11 A 2750  TYR LEU THR VAL ASN LYS ARG LEU PRO ALA LEU LEU GLU          
SEQRES  12 A 2750  LYS ASN ALA MET ARG VAL THR LEU ASP GLU ALA GLY ASN          
SEQRES  13 A 2750  GLU GLY SER TRP PHE TYR ILE GLN PRO PHE TYR LYS LEU          
SEQRES  14 A 2750  ARG SER ILE GLY ASP SER VAL VAL ILE GLY ASP LYS VAL          
SEQRES  15 A 2750  VAL LEU ASN PRO VAL ASN ALA GLY GLN PRO LEU HIS ALA          
SEQRES  16 A 2750  SER SER HIS GLN LEU VAL ASP ASN PRO GLY CYS ASN GLU          
SEQRES  17 A 2750  VAL ASN SER VAL ASN CYS ASN THR SER TRP LYS ILE VAL          
SEQRES  18 A 2750  LEU PHE MET LYS TRP SER ASP ASN LYS ASP ASP ILE LEU          
SEQRES  19 A 2750  LYS GLY GLY ASP VAL VAL ARG LEU PHE HIS ALA GLU GLN          
SEQRES  20 A 2750  GLU LYS PHE LEU THR CYS ASP GLU HIS ARG LYS LYS GLN          
SEQRES  21 A 2750  HIS VAL PHE LEU ARG THR THR GLY ARG GLN SER ALA THR          
SEQRES  22 A 2750  SER ALA THR SER SER LYS ALA LEU TRP GLU VAL GLU VAL          
SEQRES  23 A 2750  VAL GLN HIS ASP PRO CYS ARG GLY GLY ALA GLY TYR TRP          
SEQRES  24 A 2750  ASN SER LEU PHE ARG PHE LYS HIS LEU ALA THR GLY HIS          
SEQRES  25 A 2750  TYR LEU ALA ALA GLU VAL ASP PRO ASP PHE GLU GLU GLU          
SEQRES  26 A 2750  CYS LEU GLU PHE GLN PRO SER VAL ASP PRO ASP GLN ASP          
SEQRES  27 A 2750  ALA SER ARG SER ARG LEU ARG ASN ALA GLN GLU LYS MET          
SEQRES  28 A 2750  VAL TYR SER LEU VAL SER VAL PRO GLU GLY ASN ASP ILE          
SEQRES  29 A 2750  SER SER ILE PHE GLU LEU ASP PRO THR THR LEU ARG GLY          
SEQRES  30 A 2750  GLY ASP SER LEU VAL PRO ARG ASN SER TYR VAL ARG LEU          
SEQRES  31 A 2750  ARG HIS LEU CYS THR ASN THR TRP VAL HIS SER THR ASN          
SEQRES  32 A 2750  ILE PRO ILE ASP LYS GLU GLU GLU LYS PRO VAL MET LEU          
SEQRES  33 A 2750  LYS ILE GLY THR SER PRO LEU LYS GLU ASP LYS GLU ALA          
SEQRES  34 A 2750  PHE ALA ILE VAL PRO VAL SER PRO ALA GLU VAL ARG ASP          
SEQRES  35 A 2750  LEU ASP PHE ALA ASN ASP ALA SER LYS VAL LEU GLY SER          
SEQRES  36 A 2750  ILE ALA GLY LYS LEU GLU LYS GLY THR ILE THR GLN ASN          
SEQRES  37 A 2750  GLU ARG ARG SER VAL THR LYS LEU LEU GLU ASP LEU VAL          
SEQRES  38 A 2750  TYR PHE VAL THR GLY GLY THR ASN SER GLY GLN ASP VAL          
SEQRES  39 A 2750  LEU GLU VAL VAL PHE SER LYS PRO ASN ARG GLU ARG GLN          
SEQRES  40 A 2750  LYS LEU MET ARG GLU GLN ASN ILE LEU LYS GLN ILE PHE          
SEQRES  41 A 2750  LYS LEU LEU GLN ALA PRO PHE THR ASP CYS GLY ASP GLY          
SEQRES  42 A 2750  PRO MET LEU ARG LEU GLU GLU LEU GLY ASP GLN ARG HIS          
SEQRES  43 A 2750  ALA PRO PHE ARG HIS ILE CYS ARG LEU CYS TYR ARG VAL          
SEQRES  44 A 2750  LEU ARG HIS SER GLN GLN ASP TYR ARG LYS ASN GLN GLU          
SEQRES  45 A 2750  TYR ILE ALA LYS GLN PHE GLY PHE MET GLN LYS GLN ILE          
SEQRES  46 A 2750  GLY TYR ASP VAL LEU ALA GLU ASP THR ILE THR ALA LEU          
SEQRES  47 A 2750  LEU HIS ASN ASN ARG LYS LEU LEU GLU LYS HIS ILE THR          
SEQRES  48 A 2750  ALA ALA GLU ILE ASP THR PHE VAL SER LEU VAL ARG LYS          
SEQRES  49 A 2750  ASN ARG GLU PRO ARG PHE LEU ASP TYR LEU SER ASP LEU          
SEQRES  50 A 2750  CYS VAL SER MET ASN LYS SER ILE PRO VAL THR GLN GLU          
SEQRES  51 A 2750  LEU ILE CYS LYS ALA VAL LEU ASN PRO THR ASN ALA ASP          
SEQRES  52 A 2750  ILE LEU ILE GLU THR LYS LEU VAL LEU SER ARG PHE GLU          
SEQRES  53 A 2750  PHE GLU GLY VAL SER THR GLY GLU ASN ALA LEU GLU ALA          
SEQRES  54 A 2750  GLY GLU ASP GLU GLU GLU VAL TRP LEU PHE TRP ARG ASP          
SEQRES  55 A 2750  SER ASN LYS GLU ILE ARG SER LYS SER VAL ARG GLU LEU          
SEQRES  56 A 2750  ALA GLN ASP ALA LYS GLU GLY GLN LYS GLU ASP ARG ASP          
SEQRES  57 A 2750  VAL LEU SER TYR TYR ARG TYR GLN LEU ASN LEU PHE ALA          
SEQRES  58 A 2750  ARG MET CYS LEU ASP ARG GLN TYR LEU ALA ILE ASN GLU          
SEQRES  59 A 2750  ILE SER GLY GLN LEU ASP VAL ASP LEU ILE LEU ARG CYS          
SEQRES  60 A 2750  MET SER ASP GLU ASN LEU PRO TYR ASP LEU ARG ALA SER          
SEQRES  61 A 2750  PHE CYS ARG LEU MET LEU HIS MET HIS VAL ASP ARG ASP          
SEQRES  62 A 2750  PRO GLN GLU GLN VAL THR PRO VAL LYS TYR ALA ARG LEU          
SEQRES  63 A 2750  TRP SER GLU ILE PRO SER GLU ILE ALA ILE ASP ASP TYR          
SEQRES  64 A 2750  ASP SER SER GLY ALA SER LYS ASP GLU ILE LYS GLU ARG          
SEQRES  65 A 2750  PHE ALA GLN THR MET GLU PHE VAL GLU GLU TYR LEU ARG          
SEQRES  66 A 2750  ASP VAL VAL CYS GLN ARG PHE PRO PHE SER ASP LYS GLU          
SEQRES  67 A 2750  LYS ASN LYS LEU THR PHE GLU VAL VAL ASN LEU ALA ARG          
SEQRES  68 A 2750  ASN LEU ILE TYR PHE GLY PHE TYR ASN PHE SER ASP LEU          
SEQRES  69 A 2750  LEU ARG LEU THR LYS ILE LEU LEU ALA ILE LEU ASP CYS          
SEQRES  70 A 2750  VAL HIS VAL THR THR ILE PHE PRO ILE SER LYS MET THR          
SEQRES  71 A 2750  LYS GLY GLU GLU ASN LYS GLY SER ASN VAL MET ARG SER          
SEQRES  72 A 2750  ILE HIS GLY VAL GLY GLU LEU MET THR GLN VAL VAL LEU          
SEQRES  73 A 2750  ARG GLY GLY GLY PHE LEU PRO MET THR PRO MET ALA ALA          
SEQRES  74 A 2750  ALA PRO GLU GLY ASN VAL LYS GLN ALA GLU PRO GLU LYS          
SEQRES  75 A 2750  GLU ASP ILE MET VAL MET ASP THR LYS LEU LYS ILE ILE          
SEQRES  76 A 2750  GLU ILE LEU GLN PHE ILE LEU ASN VAL ARG LEU ASP TYR          
SEQRES  77 A 2750  ARG ILE SER CYS LEU LEU CYS ILE PHE LYS ARG GLU PHE          
SEQRES  78 A 2750  ASP GLU SER ASN SER GLN SER SER GLU THR SER SER GLY          
SEQRES  79 A 2750  ASN SER SER GLN GLU GLY PRO SER ASN VAL PRO GLY ALA          
SEQRES  80 A 2750  LEU ASP PHE GLU HIS ILE GLU GLU GLN ALA GLU GLY ILE          
SEQRES  81 A 2750  PHE GLY GLY SER GLU GLU ASN THR PRO LEU ASP LEU ASP          
SEQRES  82 A 2750  ASP HIS GLY GLY ARG THR PHE LEU ARG VAL LEU LEU HIS          
SEQRES  83 A 2750  LEU THR MET HIS ASP TYR PRO PRO LEU VAL SER GLY ALA          
SEQRES  84 A 2750  LEU GLN LEU LEU PHE ARG HIS PHE SER GLN ARG GLN GLU          
SEQRES  85 A 2750  VAL LEU GLN ALA PHE LYS GLN VAL GLN LEU LEU VAL THR          
SEQRES  86 A 2750  SER GLN ASP VAL ASP ASN TYR LYS GLN ILE LYS GLN ASP          
SEQRES  87 A 2750  LEU ASP GLN LEU ARG SER ILE VAL GLU LYS SER GLU LEU          
SEQRES  88 A 2750  TRP VAL TYR LYS GLY GLN GLY PRO ASP GLU PRO MET ASP          
SEQRES  89 A 2750  GLY ALA SER GLY GLU ASN GLU HIS LYS LYS THR GLU GLU          
SEQRES  90 A 2750  GLY THR SER LYS PRO LEU LYS HIS GLU SER THR SER SER          
SEQRES  91 A 2750  TYR ASN TYR ARG VAL VAL LYS GLU ILE LEU ILE ARG LEU          
SEQRES  92 A 2750  SER LYS LEU CYS VAL GLN GLU SER ALA SER VAL ARG LYS          
SEQRES  93 A 2750  SER ARG LYS GLN GLN GLN ARG LEU LEU ARG ASN MET GLY          
SEQRES  94 A 2750  ALA HIS ALA VAL VAL LEU GLU LEU LEU GLN ILE PRO TYR          
SEQRES  95 A 2750  GLU LYS ALA GLU ASP THR LYS MET GLN GLU ILE MET ARG          
SEQRES  96 A 2750  LEU ALA HIS GLU PHE LEU GLN ASN PHE CYS ALA GLY ASN          
SEQRES  97 A 2750  GLN GLN ASN GLN ALA LEU LEU HIS LYS HIS ILE ASN LEU          
SEQRES  98 A 2750  PHE LEU ASN PRO GLY ILE LEU GLU ALA VAL THR MET GLN          
SEQRES  99 A 2750  HIS ILE PHE MET ASN ASN PHE GLN LEU CYS SER GLU ILE          
SEQRES 100 A 2750  ASN GLU ARG VAL VAL GLN HIS PHE VAL HIS CYS ILE GLU          
SEQRES 101 A 2750  THR HIS GLY ARG ASN VAL GLN TYR ILE LYS PHE LEU GLN          
SEQRES 102 A 2750  THR ILE VAL LYS ALA GLU GLY LYS PHE ILE LYS LYS CYS          
SEQRES 103 A 2750  GLN ASP MET VAL MET ALA GLU LEU VAL ASN SER GLY GLU          
SEQRES 104 A 2750  ASP VAL LEU VAL PHE TYR ASN ASP ARG ALA SER PHE GLN          
SEQRES 105 A 2750  THR LEU ILE GLN MET MET ARG SER GLU ARG ASP ARG MET          
SEQRES 106 A 2750  ASP GLU ASN SER PRO LEU PHE MET TYR HIS ILE HIS LEU          
SEQRES 107 A 2750  VAL GLU LEU LEU ALA VAL CYS THR GLU GLY LYS ASN VAL          
SEQRES 108 A 2750  TYR THR GLU ILE LYS CYS ASN SER LEU LEU PRO LEU ASP          
SEQRES 109 A 2750  ASP ILE VAL ARG VAL VAL THR HIS GLU ASP CYS ILE PRO          
SEQRES 110 A 2750  GLU VAL LYS ILE ALA TYR ILE ASN PHE LEU ASN HIS CYS          
SEQRES 111 A 2750  TYR VAL ASP THR GLU VAL GLU MET LYS GLU ILE TYR THR          
SEQRES 112 A 2750  SER ASN HIS MET TRP LYS LEU PHE GLU ASN PHE LEU VAL          
SEQRES 113 A 2750  ASP ILE CYS ARG ALA CYS ASN ASN THR SER ASP ARG LYS          
SEQRES 114 A 2750  HIS ALA ASP SER VAL LEU GLU LYS TYR VAL THR GLU ILE          
SEQRES 115 A 2750  VAL MET SER ILE VAL THR THR PHE PHE SER SER PRO PHE          
SEQRES 116 A 2750  SER ASP GLN SER THR THR LEU GLN THR ARG GLN PRO VAL          
SEQRES 117 A 2750  PHE VAL GLN LEU LEU GLN GLY VAL PHE ARG VAL TYR HIS          
SEQRES 118 A 2750  CYS ASN TRP LEU MET PRO SER GLN LYS ALA SER VAL GLU          
SEQRES 119 A 2750  SER CYS ILE ARG VAL LEU SER ASP VAL ALA LYS SER ARG          
SEQRES 120 A 2750  ALA ILE ALA ILE PRO VAL ASP LEU ASP SER GLN VAL ASN          
SEQRES 121 A 2750  ASN LEU PHE LEU LYS SER HIS ASN ILE VAL GLN LYS THR          
SEQRES 122 A 2750  ALA MET ASN TRP ARG LEU SER ALA ARG ASN ALA ALA ARG          
SEQRES 123 A 2750  ARG ASP SER VAL LEU ALA ALA SER ARG ASP TYR ARG ASN          
SEQRES 124 A 2750  ILE ILE GLU ARG LEU GLN ASP ILE VAL SER ALA LEU GLU          
SEQRES 125 A 2750  ASP ARG LEU ARG PRO LEU VAL GLN ALA GLU LEU SER VAL          
SEQRES 126 A 2750  LEU VAL ASP VAL LEU HIS ARG PRO GLU LEU LEU PHE PRO          
SEQRES 127 A 2750  GLU ASN THR ASP ALA ARG ARG LYS CYS GLU SER GLY GLY          
SEQRES 128 A 2750  PHE ILE CYS LYS LEU ILE LYS HIS THR LYS GLN LEU LEU          
SEQRES 129 A 2750  GLU GLU ASN GLU GLU LYS LEU CYS ILE LYS VAL LEU GLN          
SEQRES 130 A 2750  THR LEU ARG GLU MET MET THR LYS ASP ARG GLY TYR GLY          
SEQRES 131 A 2750  GLU LYS GLN ILE SER ILE ASP GLU LEU GLU ASN ALA GLU          
SEQRES 132 A 2750  LEU PRO GLN PRO PRO GLU ALA GLU ASN SER THR GLU GLN          
SEQRES 133 A 2750  GLU LEU GLU PRO SER PRO PRO LEU ARG GLN LEU GLU ASP          
SEQRES 134 A 2750  HIS LYS ARG GLY GLU ALA LEU ARG GLN ILE LEU VAL ASN          
SEQRES 135 A 2750  ARG TYR TYR GLY ASN ILE ARG PRO SER GLY ARG ARG GLU          
SEQRES 136 A 2750  SER LEU THR SER PHE GLY ASN GLY PRO LEU SER PRO GLY          
SEQRES 137 A 2750  GLY PRO SER LYS PRO GLY GLY GLY GLY GLY GLY PRO GLY          
SEQRES 138 A 2750  SER GLY SER THR SER ARG GLY GLU MET SER LEU ALA GLU          
SEQRES 139 A 2750  VAL GLN CYS HIS LEU ASP LYS GLU GLY ALA SER ASN LEU          
SEQRES 140 A 2750  VAL ILE ASP LEU ILE MET ASN ALA SER SER ASP ARG VAL          
SEQRES 141 A 2750  PHE HIS GLU SER ILE LEU LEU ALA ILE ALA LEU LEU GLU          
SEQRES 142 A 2750  GLY GLY ASN THR THR ILE GLN HIS SER PHE PHE CYS ARG          
SEQRES 143 A 2750  LEU THR GLU ASP LYS LYS SER GLU LYS PHE PHE LYS VAL          
SEQRES 144 A 2750  PHE TYR ASP ARG MET LYS VAL ALA GLN GLN GLU ILE LYS          
SEQRES 145 A 2750  ALA THR VAL THR VAL ASN THR SER ASP LEU GLY ASN LYS          
SEQRES 146 A 2750  LYS LYS ASP ASP GLU VAL ASP ARG ASP ALA PRO SER ARG          
SEQRES 147 A 2750  LYS LYS ALA LYS GLU PRO THR THR GLN ILE THR GLU GLU          
SEQRES 148 A 2750  VAL ARG ASP GLN LEU LEU GLU ALA SER ALA ALA THR ARG          
SEQRES 149 A 2750  LYS ALA PHE THR THR PHE ARG ARG GLU ALA ASP PRO ASP          
SEQRES 150 A 2750  ASP HIS TYR GLN SER GLY GLU GLY THR GLN ALA THR THR          
SEQRES 151 A 2750  ASP LYS ALA LYS ASP ASP LEU GLU MET SER ALA VAL ILE          
SEQRES 152 A 2750  THR ILE MET GLN PRO ILE LEU ARG PHE LEU GLN LEU LEU          
SEQRES 153 A 2750  CYS GLU ASN HIS ASN ARG ASP LEU GLN ASN PHE LEU ARG          
SEQRES 154 A 2750  CYS GLN ASN ASN LYS THR ASN TYR ASN LEU VAL CYS GLU          
SEQRES 155 A 2750  THR LEU GLN PHE LEU ASP CYS ILE CYS GLY SER THR THR          
SEQRES 156 A 2750  GLY GLY LEU GLY LEU LEU GLY LEU TYR ILE ASN GLU LYS          
SEQRES 157 A 2750  ASN VAL ALA LEU ILE ASN GLN THR LEU GLU SER LEU THR          
SEQRES 158 A 2750  GLU TYR CYS GLN GLY PRO CYS HIS GLU ASN GLN ASN CYS          
SEQRES 159 A 2750  ILE ALA THR HIS GLU SER ASN GLY ILE ASP ILE ILE THR          
SEQRES 160 A 2750  ALA LEU ILE LEU ASN ASP ILE ASN PRO LEU GLY LYS LYS          
SEQRES 161 A 2750  ARG MET ASP LEU VAL LEU GLU LEU LYS ASN ASN ALA SER          
SEQRES 162 A 2750  LYS LEU LEU LEU ALA ILE MET GLU SER ARG HIS ASP SER          
SEQRES 163 A 2750  GLU ASN ALA GLU ARG ILE LEU TYR ASN MET ARG PRO LYS          
SEQRES 164 A 2750  GLU LEU VAL GLU VAL ILE LYS LYS ALA TYR MET GLN GLY          
SEQRES 165 A 2750  GLU VAL GLU PHE GLU ASP GLY GLU ASN GLY GLU ASP GLY          
SEQRES 166 A 2750  ALA ALA SER PRO ARG ASN VAL GLY HIS ASN ILE TYR ILE          
SEQRES 167 A 2750  LEU ALA HIS GLN LEU ALA ARG HIS ASN LYS GLU LEU GLN          
SEQRES 168 A 2750  THR MET LEU LYS PRO GLY GLY GLN VAL ASP GLY ASP GLU          
SEQRES 169 A 2750  ALA LEU GLU PHE TYR ALA LYS HIS THR ALA GLN ILE GLU          
SEQRES 170 A 2750  ILE VAL ARG LEU ASP ARG THR MET GLU GLN ILE VAL PHE          
SEQRES 171 A 2750  PRO VAL PRO SER ILE CYS GLU PHE LEU THR LYS GLU SER          
SEQRES 172 A 2750  LYS LEU ARG ILE TYR TYR THR THR GLU ARG ASP GLU GLN          
SEQRES 173 A 2750  GLY SER LYS ILE ASN ASP PHE PHE LEU ARG SER GLU ASP          
SEQRES 174 A 2750  LEU PHE ASN GLU MET ASN TRP GLN LYS LYS LEU ARG ALA          
SEQRES 175 A 2750  GLN PRO VAL LEU TYR TRP CYS ALA ARG ASN MET SER PHE          
SEQRES 176 A 2750  TRP SER SER ILE SER PHE ASN LEU ALA VAL LEU MET ASN          
SEQRES 177 A 2750  LEU LEU VAL ALA PHE PHE TYR PRO PHE LYS GLY VAL ARG          
SEQRES 178 A 2750  GLY GLY THR LEU GLU PRO HIS TRP SER GLY LEU LEU TRP          
SEQRES 179 A 2750  THR ALA MET LEU ILE SER LEU ALA ILE VAL ILE ALA LEU          
SEQRES 180 A 2750  PRO LYS PRO HIS GLY ILE ARG ALA LEU ILE ALA SER THR          
SEQRES 181 A 2750  ILE LEU ARG LEU ILE PHE SER VAL GLY LEU GLN PRO THR          
SEQRES 182 A 2750  LEU PHE LEU LEU GLY ALA PHE ASN VAL CYS ASN LYS ILE          
SEQRES 183 A 2750  ILE PHE LEU MET SER PHE VAL GLY ASN CYS GLY THR PHE          
SEQRES 184 A 2750  THR ARG GLY TYR ARG ALA MET VAL LEU ASP VAL GLU PHE          
SEQRES 185 A 2750  LEU TYR HIS LEU LEU TYR LEU LEU ILE CYS ALA MET GLY          
SEQRES 186 A 2750  LEU PHE VAL HIS GLU PHE PHE TYR SER LEU LEU LEU PHE          
SEQRES 187 A 2750  ASP LEU VAL TYR ARG GLU GLU THR LEU LEU ASN VAL ILE          
SEQRES 188 A 2750  LYS SER VAL THR ARG ASN GLY ARG PRO ILE ILE LEU THR          
SEQRES 189 A 2750  ALA ALA LEU ALA LEU ILE LEU VAL TYR LEU PHE SER ILE          
SEQRES 190 A 2750  VAL GLY TYR LEU PHE PHE LYS ASP ASP PHE ILE LEU GLU          
SEQRES 191 A 2750  VAL ASP ARG LEU PRO ASN GLU THR ALA GLY PRO GLU THR          
SEQRES 192 A 2750  GLY GLU SER LEU ALA ASN ASP PHE LEU TYR SER ASP VAL          
SEQRES 193 A 2750  CYS ARG VAL GLU THR GLY GLU ASN CYS THR SER PRO ALA          
SEQRES 194 A 2750  PRO LYS GLU GLU LEU LEU PRO VAL GLU GLU THR GLU GLN          
SEQRES 195 A 2750  ASP LYS GLU HIS THR CYS GLU THR LEU LEU MET CYS ILE          
SEQRES 196 A 2750  VAL THR VAL LEU SER HIS GLY LEU ARG SER GLY GLY GLY          
SEQRES 197 A 2750  VAL GLY ASP VAL LEU ARG LYS PRO SER LYS GLU GLU PRO          
SEQRES 198 A 2750  LEU PHE ALA ALA ARG VAL ILE TYR ASP LEU LEU PHE PHE          
SEQRES 199 A 2750  PHE MET VAL ILE ILE ILE VAL LEU ASN LEU ILE PHE GLY          
SEQRES 200 A 2750  VAL ILE ILE ASP THR PHE ALA ASP LEU ARG SER GLU LYS          
SEQRES 201 A 2750  GLN LYS LYS GLU GLU ILE LEU LYS THR THR CYS PHE ILE          
SEQRES 202 A 2750  CYS GLY LEU GLU ARG ASP LYS PHE ASP ASN LYS THR VAL          
SEQRES 203 A 2750  THR PHE GLU GLU HIS ILE LYS GLU GLU HIS ASN MET TRP          
SEQRES 204 A 2750  HIS TYR LEU CYS PHE ILE VAL LEU VAL LYS VAL LYS ASP          
SEQRES 205 A 2750  SER THR GLU TYR THR GLY PRO GLU SER TYR VAL ALA GLU          
SEQRES 206 A 2750  MET ILE ARG GLU ARG ASN LEU ASP TRP PHE PRO ARG MET          
SEQRES 207 A 2750  ARG ALA MET SER LEU VAL SER SER ASP SER GLU GLY GLU          
SEQRES 208 A 2750  GLN ASN GLU LEU ARG ASN LEU GLN GLU LYS LEU GLU SER          
SEQRES 209 A 2750  THR MET LYS LEU VAL THR ASN LEU SER GLY GLN LEU SER          
SEQRES 210 A 2750  GLU LEU LYS ASP GLN MET THR GLU GLN ARG LYS GLN LYS          
SEQRES 211 A 2750  GLN ARG ILE GLY LEU LEU GLY HIS PRO PRO HIS MET ASN          
SEQRES 212 A 2750  VAL ASN PRO GLN GLN PRO ALA                                  
SEQRES   1 B 2750  MET SER ASP LYS MET SER SER PHE LEU HIS ILE GLY ASP          
SEQRES   2 B 2750  ILE CYS SER LEU TYR ALA GLU GLY SER THR ASN GLY PHE          
SEQRES   3 B 2750  ILE SER THR LEU GLY LEU VAL ASP ASP ARG CYS VAL VAL          
SEQRES   4 B 2750  GLN PRO GLU ALA GLY ASP LEU ASN ASN PRO PRO LYS LYS          
SEQRES   5 B 2750  PHE ARG ASP CYS LEU PHE LYS LEU CYS PRO MET ASN ARG          
SEQRES   6 B 2750  TYR SER ALA GLN LYS GLN PHE TRP LYS ALA ALA LYS PRO          
SEQRES   7 B 2750  GLY ALA ASN SER THR THR ASP ALA VAL LEU LEU ASN LYS          
SEQRES   8 B 2750  LEU HIS HIS ALA ALA ASP LEU GLU LYS LYS GLN ASN GLU          
SEQRES   9 B 2750  THR GLU ASN ARG LYS LEU LEU GLY THR VAL ILE GLN TYR          
SEQRES  10 B 2750  GLY ASN VAL ILE GLN LEU LEU HIS LEU LYS SER ASN LYS          
SEQRES  11 B 2750  TYR LEU THR VAL ASN LYS ARG LEU PRO ALA LEU LEU GLU          
SEQRES  12 B 2750  LYS ASN ALA MET ARG VAL THR LEU ASP GLU ALA GLY ASN          
SEQRES  13 B 2750  GLU GLY SER TRP PHE TYR ILE GLN PRO PHE TYR LYS LEU          
SEQRES  14 B 2750  ARG SER ILE GLY ASP SER VAL VAL ILE GLY ASP LYS VAL          
SEQRES  15 B 2750  VAL LEU ASN PRO VAL ASN ALA GLY GLN PRO LEU HIS ALA          
SEQRES  16 B 2750  SER SER HIS GLN LEU VAL ASP ASN PRO GLY CYS ASN GLU          
SEQRES  17 B 2750  VAL ASN SER VAL ASN CYS ASN THR SER TRP LYS ILE VAL          
SEQRES  18 B 2750  LEU PHE MET LYS TRP SER ASP ASN LYS ASP ASP ILE LEU          
SEQRES  19 B 2750  LYS GLY GLY ASP VAL VAL ARG LEU PHE HIS ALA GLU GLN          
SEQRES  20 B 2750  GLU LYS PHE LEU THR CYS ASP GLU HIS ARG LYS LYS GLN          
SEQRES  21 B 2750  HIS VAL PHE LEU ARG THR THR GLY ARG GLN SER ALA THR          
SEQRES  22 B 2750  SER ALA THR SER SER LYS ALA LEU TRP GLU VAL GLU VAL          
SEQRES  23 B 2750  VAL GLN HIS ASP PRO CYS ARG GLY GLY ALA GLY TYR TRP          
SEQRES  24 B 2750  ASN SER LEU PHE ARG PHE LYS HIS LEU ALA THR GLY HIS          
SEQRES  25 B 2750  TYR LEU ALA ALA GLU VAL ASP PRO ASP PHE GLU GLU GLU          
SEQRES  26 B 2750  CYS LEU GLU PHE GLN PRO SER VAL ASP PRO ASP GLN ASP          
SEQRES  27 B 2750  ALA SER ARG SER ARG LEU ARG ASN ALA GLN GLU LYS MET          
SEQRES  28 B 2750  VAL TYR SER LEU VAL SER VAL PRO GLU GLY ASN ASP ILE          
SEQRES  29 B 2750  SER SER ILE PHE GLU LEU ASP PRO THR THR LEU ARG GLY          
SEQRES  30 B 2750  GLY ASP SER LEU VAL PRO ARG ASN SER TYR VAL ARG LEU          
SEQRES  31 B 2750  ARG HIS LEU CYS THR ASN THR TRP VAL HIS SER THR ASN          
SEQRES  32 B 2750  ILE PRO ILE ASP LYS GLU GLU GLU LYS PRO VAL MET LEU          
SEQRES  33 B 2750  LYS ILE GLY THR SER PRO LEU LYS GLU ASP LYS GLU ALA          
SEQRES  34 B 2750  PHE ALA ILE VAL PRO VAL SER PRO ALA GLU VAL ARG ASP          
SEQRES  35 B 2750  LEU ASP PHE ALA ASN ASP ALA SER LYS VAL LEU GLY SER          
SEQRES  36 B 2750  ILE ALA GLY LYS LEU GLU LYS GLY THR ILE THR GLN ASN          
SEQRES  37 B 2750  GLU ARG ARG SER VAL THR LYS LEU LEU GLU ASP LEU VAL          
SEQRES  38 B 2750  TYR PHE VAL THR GLY GLY THR ASN SER GLY GLN ASP VAL          
SEQRES  39 B 2750  LEU GLU VAL VAL PHE SER LYS PRO ASN ARG GLU ARG GLN          
SEQRES  40 B 2750  LYS LEU MET ARG GLU GLN ASN ILE LEU LYS GLN ILE PHE          
SEQRES  41 B 2750  LYS LEU LEU GLN ALA PRO PHE THR ASP CYS GLY ASP GLY          
SEQRES  42 B 2750  PRO MET LEU ARG LEU GLU GLU LEU GLY ASP GLN ARG HIS          
SEQRES  43 B 2750  ALA PRO PHE ARG HIS ILE CYS ARG LEU CYS TYR ARG VAL          
SEQRES  44 B 2750  LEU ARG HIS SER GLN GLN ASP TYR ARG LYS ASN GLN GLU          
SEQRES  45 B 2750  TYR ILE ALA LYS GLN PHE GLY PHE MET GLN LYS GLN ILE          
SEQRES  46 B 2750  GLY TYR ASP VAL LEU ALA GLU ASP THR ILE THR ALA LEU          
SEQRES  47 B 2750  LEU HIS ASN ASN ARG LYS LEU LEU GLU LYS HIS ILE THR          
SEQRES  48 B 2750  ALA ALA GLU ILE ASP THR PHE VAL SER LEU VAL ARG LYS          
SEQRES  49 B 2750  ASN ARG GLU PRO ARG PHE LEU ASP TYR LEU SER ASP LEU          
SEQRES  50 B 2750  CYS VAL SER MET ASN LYS SER ILE PRO VAL THR GLN GLU          
SEQRES  51 B 2750  LEU ILE CYS LYS ALA VAL LEU ASN PRO THR ASN ALA ASP          
SEQRES  52 B 2750  ILE LEU ILE GLU THR LYS LEU VAL LEU SER ARG PHE GLU          
SEQRES  53 B 2750  PHE GLU GLY VAL SER THR GLY GLU ASN ALA LEU GLU ALA          
SEQRES  54 B 2750  GLY GLU ASP GLU GLU GLU VAL TRP LEU PHE TRP ARG ASP          
SEQRES  55 B 2750  SER ASN LYS GLU ILE ARG SER LYS SER VAL ARG GLU LEU          
SEQRES  56 B 2750  ALA GLN ASP ALA LYS GLU GLY GLN LYS GLU ASP ARG ASP          
SEQRES  57 B 2750  VAL LEU SER TYR TYR ARG TYR GLN LEU ASN LEU PHE ALA          
SEQRES  58 B 2750  ARG MET CYS LEU ASP ARG GLN TYR LEU ALA ILE ASN GLU          
SEQRES  59 B 2750  ILE SER GLY GLN LEU ASP VAL ASP LEU ILE LEU ARG CYS          
SEQRES  60 B 2750  MET SER ASP GLU ASN LEU PRO TYR ASP LEU ARG ALA SER          
SEQRES  61 B 2750  PHE CYS ARG LEU MET LEU HIS MET HIS VAL ASP ARG ASP          
SEQRES  62 B 2750  PRO GLN GLU GLN VAL THR PRO VAL LYS TYR ALA ARG LEU          
SEQRES  63 B 2750  TRP SER GLU ILE PRO SER GLU ILE ALA ILE ASP ASP TYR          
SEQRES  64 B 2750  ASP SER SER GLY ALA SER LYS ASP GLU ILE LYS GLU ARG          
SEQRES  65 B 2750  PHE ALA GLN THR MET GLU PHE VAL GLU GLU TYR LEU ARG          
SEQRES  66 B 2750  ASP VAL VAL CYS GLN ARG PHE PRO PHE SER ASP LYS GLU          
SEQRES  67 B 2750  LYS ASN LYS LEU THR PHE GLU VAL VAL ASN LEU ALA ARG          
SEQRES  68 B 2750  ASN LEU ILE TYR PHE GLY PHE TYR ASN PHE SER ASP LEU          
SEQRES  69 B 2750  LEU ARG LEU THR LYS ILE LEU LEU ALA ILE LEU ASP CYS          
SEQRES  70 B 2750  VAL HIS VAL THR THR ILE PHE PRO ILE SER LYS MET THR          
SEQRES  71 B 2750  LYS GLY GLU GLU ASN LYS GLY SER ASN VAL MET ARG SER          
SEQRES  72 B 2750  ILE HIS GLY VAL GLY GLU LEU MET THR GLN VAL VAL LEU          
SEQRES  73 B 2750  ARG GLY GLY GLY PHE LEU PRO MET THR PRO MET ALA ALA          
SEQRES  74 B 2750  ALA PRO GLU GLY ASN VAL LYS GLN ALA GLU PRO GLU LYS          
SEQRES  75 B 2750  GLU ASP ILE MET VAL MET ASP THR LYS LEU LYS ILE ILE          
SEQRES  76 B 2750  GLU ILE LEU GLN PHE ILE LEU ASN VAL ARG LEU ASP TYR          
SEQRES  77 B 2750  ARG ILE SER CYS LEU LEU CYS ILE PHE LYS ARG GLU PHE          
SEQRES  78 B 2750  ASP GLU SER ASN SER GLN SER SER GLU THR SER SER GLY          
SEQRES  79 B 2750  ASN SER SER GLN GLU GLY PRO SER ASN VAL PRO GLY ALA          
SEQRES  80 B 2750  LEU ASP PHE GLU HIS ILE GLU GLU GLN ALA GLU GLY ILE          
SEQRES  81 B 2750  PHE GLY GLY SER GLU GLU ASN THR PRO LEU ASP LEU ASP          
SEQRES  82 B 2750  ASP HIS GLY GLY ARG THR PHE LEU ARG VAL LEU LEU HIS          
SEQRES  83 B 2750  LEU THR MET HIS ASP TYR PRO PRO LEU VAL SER GLY ALA          
SEQRES  84 B 2750  LEU GLN LEU LEU PHE ARG HIS PHE SER GLN ARG GLN GLU          
SEQRES  85 B 2750  VAL LEU GLN ALA PHE LYS GLN VAL GLN LEU LEU VAL THR          
SEQRES  86 B 2750  SER GLN ASP VAL ASP ASN TYR LYS GLN ILE LYS GLN ASP          
SEQRES  87 B 2750  LEU ASP GLN LEU ARG SER ILE VAL GLU LYS SER GLU LEU          
SEQRES  88 B 2750  TRP VAL TYR LYS GLY GLN GLY PRO ASP GLU PRO MET ASP          
SEQRES  89 B 2750  GLY ALA SER GLY GLU ASN GLU HIS LYS LYS THR GLU GLU          
SEQRES  90 B 2750  GLY THR SER LYS PRO LEU LYS HIS GLU SER THR SER SER          
SEQRES  91 B 2750  TYR ASN TYR ARG VAL VAL LYS GLU ILE LEU ILE ARG LEU          
SEQRES  92 B 2750  SER LYS LEU CYS VAL GLN GLU SER ALA SER VAL ARG LYS          
SEQRES  93 B 2750  SER ARG LYS GLN GLN GLN ARG LEU LEU ARG ASN MET GLY          
SEQRES  94 B 2750  ALA HIS ALA VAL VAL LEU GLU LEU LEU GLN ILE PRO TYR          
SEQRES  95 B 2750  GLU LYS ALA GLU ASP THR LYS MET GLN GLU ILE MET ARG          
SEQRES  96 B 2750  LEU ALA HIS GLU PHE LEU GLN ASN PHE CYS ALA GLY ASN          
SEQRES  97 B 2750  GLN GLN ASN GLN ALA LEU LEU HIS LYS HIS ILE ASN LEU          
SEQRES  98 B 2750  PHE LEU ASN PRO GLY ILE LEU GLU ALA VAL THR MET GLN          
SEQRES  99 B 2750  HIS ILE PHE MET ASN ASN PHE GLN LEU CYS SER GLU ILE          
SEQRES 100 B 2750  ASN GLU ARG VAL VAL GLN HIS PHE VAL HIS CYS ILE GLU          
SEQRES 101 B 2750  THR HIS GLY ARG ASN VAL GLN TYR ILE LYS PHE LEU GLN          
SEQRES 102 B 2750  THR ILE VAL LYS ALA GLU GLY LYS PHE ILE LYS LYS CYS          
SEQRES 103 B 2750  GLN ASP MET VAL MET ALA GLU LEU VAL ASN SER GLY GLU          
SEQRES 104 B 2750  ASP VAL LEU VAL PHE TYR ASN ASP ARG ALA SER PHE GLN          
SEQRES 105 B 2750  THR LEU ILE GLN MET MET ARG SER GLU ARG ASP ARG MET          
SEQRES 106 B 2750  ASP GLU ASN SER PRO LEU PHE MET TYR HIS ILE HIS LEU          
SEQRES 107 B 2750  VAL GLU LEU LEU ALA VAL CYS THR GLU GLY LYS ASN VAL          
SEQRES 108 B 2750  TYR THR GLU ILE LYS CYS ASN SER LEU LEU PRO LEU ASP          
SEQRES 109 B 2750  ASP ILE VAL ARG VAL VAL THR HIS GLU ASP CYS ILE PRO          
SEQRES 110 B 2750  GLU VAL LYS ILE ALA TYR ILE ASN PHE LEU ASN HIS CYS          
SEQRES 111 B 2750  TYR VAL ASP THR GLU VAL GLU MET LYS GLU ILE TYR THR          
SEQRES 112 B 2750  SER ASN HIS MET TRP LYS LEU PHE GLU ASN PHE LEU VAL          
SEQRES 113 B 2750  ASP ILE CYS ARG ALA CYS ASN ASN THR SER ASP ARG LYS          
SEQRES 114 B 2750  HIS ALA ASP SER VAL LEU GLU LYS TYR VAL THR GLU ILE          
SEQRES 115 B 2750  VAL MET SER ILE VAL THR THR PHE PHE SER SER PRO PHE          
SEQRES 116 B 2750  SER ASP GLN SER THR THR LEU GLN THR ARG GLN PRO VAL          
SEQRES 117 B 2750  PHE VAL GLN LEU LEU GLN GLY VAL PHE ARG VAL TYR HIS          
SEQRES 118 B 2750  CYS ASN TRP LEU MET PRO SER GLN LYS ALA SER VAL GLU          
SEQRES 119 B 2750  SER CYS ILE ARG VAL LEU SER ASP VAL ALA LYS SER ARG          
SEQRES 120 B 2750  ALA ILE ALA ILE PRO VAL ASP LEU ASP SER GLN VAL ASN          
SEQRES 121 B 2750  ASN LEU PHE LEU LYS SER HIS ASN ILE VAL GLN LYS THR          
SEQRES 122 B 2750  ALA MET ASN TRP ARG LEU SER ALA ARG ASN ALA ALA ARG          
SEQRES 123 B 2750  ARG ASP SER VAL LEU ALA ALA SER ARG ASP TYR ARG ASN          
SEQRES 124 B 2750  ILE ILE GLU ARG LEU GLN ASP ILE VAL SER ALA LEU GLU          
SEQRES 125 B 2750  ASP ARG LEU ARG PRO LEU VAL GLN ALA GLU LEU SER VAL          
SEQRES 126 B 2750  LEU VAL ASP VAL LEU HIS ARG PRO GLU LEU LEU PHE PRO          
SEQRES 127 B 2750  GLU ASN THR ASP ALA ARG ARG LYS CYS GLU SER GLY GLY          
SEQRES 128 B 2750  PHE ILE CYS LYS LEU ILE LYS HIS THR LYS GLN LEU LEU          
SEQRES 129 B 2750  GLU GLU ASN GLU GLU LYS LEU CYS ILE LYS VAL LEU GLN          
SEQRES 130 B 2750  THR LEU ARG GLU MET MET THR LYS ASP ARG GLY TYR GLY          
SEQRES 131 B 2750  GLU LYS GLN ILE SER ILE ASP GLU LEU GLU ASN ALA GLU          
SEQRES 132 B 2750  LEU PRO GLN PRO PRO GLU ALA GLU ASN SER THR GLU GLN          
SEQRES 133 B 2750  GLU LEU GLU PRO SER PRO PRO LEU ARG GLN LEU GLU ASP          
SEQRES 134 B 2750  HIS LYS ARG GLY GLU ALA LEU ARG GLN ILE LEU VAL ASN          
SEQRES 135 B 2750  ARG TYR TYR GLY ASN ILE ARG PRO SER GLY ARG ARG GLU          
SEQRES 136 B 2750  SER LEU THR SER PHE GLY ASN GLY PRO LEU SER PRO GLY          
SEQRES 137 B 2750  GLY PRO SER LYS PRO GLY GLY GLY GLY GLY GLY PRO GLY          
SEQRES 138 B 2750  SER GLY SER THR SER ARG GLY GLU MET SER LEU ALA GLU          
SEQRES 139 B 2750  VAL GLN CYS HIS LEU ASP LYS GLU GLY ALA SER ASN LEU          
SEQRES 140 B 2750  VAL ILE ASP LEU ILE MET ASN ALA SER SER ASP ARG VAL          
SEQRES 141 B 2750  PHE HIS GLU SER ILE LEU LEU ALA ILE ALA LEU LEU GLU          
SEQRES 142 B 2750  GLY GLY ASN THR THR ILE GLN HIS SER PHE PHE CYS ARG          
SEQRES 143 B 2750  LEU THR GLU ASP LYS LYS SER GLU LYS PHE PHE LYS VAL          
SEQRES 144 B 2750  PHE TYR ASP ARG MET LYS VAL ALA GLN GLN GLU ILE LYS          
SEQRES 145 B 2750  ALA THR VAL THR VAL ASN THR SER ASP LEU GLY ASN LYS          
SEQRES 146 B 2750  LYS LYS ASP ASP GLU VAL ASP ARG ASP ALA PRO SER ARG          
SEQRES 147 B 2750  LYS LYS ALA LYS GLU PRO THR THR GLN ILE THR GLU GLU          
SEQRES 148 B 2750  VAL ARG ASP GLN LEU LEU GLU ALA SER ALA ALA THR ARG          
SEQRES 149 B 2750  LYS ALA PHE THR THR PHE ARG ARG GLU ALA ASP PRO ASP          
SEQRES 150 B 2750  ASP HIS TYR GLN SER GLY GLU GLY THR GLN ALA THR THR          
SEQRES 151 B 2750  ASP LYS ALA LYS ASP ASP LEU GLU MET SER ALA VAL ILE          
SEQRES 152 B 2750  THR ILE MET GLN PRO ILE LEU ARG PHE LEU GLN LEU LEU          
SEQRES 153 B 2750  CYS GLU ASN HIS ASN ARG ASP LEU GLN ASN PHE LEU ARG          
SEQRES 154 B 2750  CYS GLN ASN ASN LYS THR ASN TYR ASN LEU VAL CYS GLU          
SEQRES 155 B 2750  THR LEU GLN PHE LEU ASP CYS ILE CYS GLY SER THR THR          
SEQRES 156 B 2750  GLY GLY LEU GLY LEU LEU GLY LEU TYR ILE ASN GLU LYS          
SEQRES 157 B 2750  ASN VAL ALA LEU ILE ASN GLN THR LEU GLU SER LEU THR          
SEQRES 158 B 2750  GLU TYR CYS GLN GLY PRO CYS HIS GLU ASN GLN ASN CYS          
SEQRES 159 B 2750  ILE ALA THR HIS GLU SER ASN GLY ILE ASP ILE ILE THR          
SEQRES 160 B 2750  ALA LEU ILE LEU ASN ASP ILE ASN PRO LEU GLY LYS LYS          
SEQRES 161 B 2750  ARG MET ASP LEU VAL LEU GLU LEU LYS ASN ASN ALA SER          
SEQRES 162 B 2750  LYS LEU LEU LEU ALA ILE MET GLU SER ARG HIS ASP SER          
SEQRES 163 B 2750  GLU ASN ALA GLU ARG ILE LEU TYR ASN MET ARG PRO LYS          
SEQRES 164 B 2750  GLU LEU VAL GLU VAL ILE LYS LYS ALA TYR MET GLN GLY          
SEQRES 165 B 2750  GLU VAL GLU PHE GLU ASP GLY GLU ASN GLY GLU ASP GLY          
SEQRES 166 B 2750  ALA ALA SER PRO ARG ASN VAL GLY HIS ASN ILE TYR ILE          
SEQRES 167 B 2750  LEU ALA HIS GLN LEU ALA ARG HIS ASN LYS GLU LEU GLN          
SEQRES 168 B 2750  THR MET LEU LYS PRO GLY GLY GLN VAL ASP GLY ASP GLU          
SEQRES 169 B 2750  ALA LEU GLU PHE TYR ALA LYS HIS THR ALA GLN ILE GLU          
SEQRES 170 B 2750  ILE VAL ARG LEU ASP ARG THR MET GLU GLN ILE VAL PHE          
SEQRES 171 B 2750  PRO VAL PRO SER ILE CYS GLU PHE LEU THR LYS GLU SER          
SEQRES 172 B 2750  LYS LEU ARG ILE TYR TYR THR THR GLU ARG ASP GLU GLN          
SEQRES 173 B 2750  GLY SER LYS ILE ASN ASP PHE PHE LEU ARG SER GLU ASP          
SEQRES 174 B 2750  LEU PHE ASN GLU MET ASN TRP GLN LYS LYS LEU ARG ALA          
SEQRES 175 B 2750  GLN PRO VAL LEU TYR TRP CYS ALA ARG ASN MET SER PHE          
SEQRES 176 B 2750  TRP SER SER ILE SER PHE ASN LEU ALA VAL LEU MET ASN          
SEQRES 177 B 2750  LEU LEU VAL ALA PHE PHE TYR PRO PHE LYS GLY VAL ARG          
SEQRES 178 B 2750  GLY GLY THR LEU GLU PRO HIS TRP SER GLY LEU LEU TRP          
SEQRES 179 B 2750  THR ALA MET LEU ILE SER LEU ALA ILE VAL ILE ALA LEU          
SEQRES 180 B 2750  PRO LYS PRO HIS GLY ILE ARG ALA LEU ILE ALA SER THR          
SEQRES 181 B 2750  ILE LEU ARG LEU ILE PHE SER VAL GLY LEU GLN PRO THR          
SEQRES 182 B 2750  LEU PHE LEU LEU GLY ALA PHE ASN VAL CYS ASN LYS ILE          
SEQRES 183 B 2750  ILE PHE LEU MET SER PHE VAL GLY ASN CYS GLY THR PHE          
SEQRES 184 B 2750  THR ARG GLY TYR ARG ALA MET VAL LEU ASP VAL GLU PHE          
SEQRES 185 B 2750  LEU TYR HIS LEU LEU TYR LEU LEU ILE CYS ALA MET GLY          
SEQRES 186 B 2750  LEU PHE VAL HIS GLU PHE PHE TYR SER LEU LEU LEU PHE          
SEQRES 187 B 2750  ASP LEU VAL TYR ARG GLU GLU THR LEU LEU ASN VAL ILE          
SEQRES 188 B 2750  LYS SER VAL THR ARG ASN GLY ARG PRO ILE ILE LEU THR          
SEQRES 189 B 2750  ALA ALA LEU ALA LEU ILE LEU VAL TYR LEU PHE SER ILE          
SEQRES 190 B 2750  VAL GLY TYR LEU PHE PHE LYS ASP ASP PHE ILE LEU GLU          
SEQRES 191 B 2750  VAL ASP ARG LEU PRO ASN GLU THR ALA GLY PRO GLU THR          
SEQRES 192 B 2750  GLY GLU SER LEU ALA ASN ASP PHE LEU TYR SER ASP VAL          
SEQRES 193 B 2750  CYS ARG VAL GLU THR GLY GLU ASN CYS THR SER PRO ALA          
SEQRES 194 B 2750  PRO LYS GLU GLU LEU LEU PRO VAL GLU GLU THR GLU GLN          
SEQRES 195 B 2750  ASP LYS GLU HIS THR CYS GLU THR LEU LEU MET CYS ILE          
SEQRES 196 B 2750  VAL THR VAL LEU SER HIS GLY LEU ARG SER GLY GLY GLY          
SEQRES 197 B 2750  VAL GLY ASP VAL LEU ARG LYS PRO SER LYS GLU GLU PRO          
SEQRES 198 B 2750  LEU PHE ALA ALA ARG VAL ILE TYR ASP LEU LEU PHE PHE          
SEQRES 199 B 2750  PHE MET VAL ILE ILE ILE VAL LEU ASN LEU ILE PHE GLY          
SEQRES 200 B 2750  VAL ILE ILE ASP THR PHE ALA ASP LEU ARG SER GLU LYS          
SEQRES 201 B 2750  GLN LYS LYS GLU GLU ILE LEU LYS THR THR CYS PHE ILE          
SEQRES 202 B 2750  CYS GLY LEU GLU ARG ASP LYS PHE ASP ASN LYS THR VAL          
SEQRES 203 B 2750  THR PHE GLU GLU HIS ILE LYS GLU GLU HIS ASN MET TRP          
SEQRES 204 B 2750  HIS TYR LEU CYS PHE ILE VAL LEU VAL LYS VAL LYS ASP          
SEQRES 205 B 2750  SER THR GLU TYR THR GLY PRO GLU SER TYR VAL ALA GLU          
SEQRES 206 B 2750  MET ILE ARG GLU ARG ASN LEU ASP TRP PHE PRO ARG MET          
SEQRES 207 B 2750  ARG ALA MET SER LEU VAL SER SER ASP SER GLU GLY GLU          
SEQRES 208 B 2750  GLN ASN GLU LEU ARG ASN LEU GLN GLU LYS LEU GLU SER          
SEQRES 209 B 2750  THR MET LYS LEU VAL THR ASN LEU SER GLY GLN LEU SER          
SEQRES 210 B 2750  GLU LEU LYS ASP GLN MET THR GLU GLN ARG LYS GLN LYS          
SEQRES 211 B 2750  GLN ARG ILE GLY LEU LEU GLY HIS PRO PRO HIS MET ASN          
SEQRES 212 B 2750  VAL ASN PRO GLN GLN PRO ALA                                  
SEQRES   1 C 2750  MET SER ASP LYS MET SER SER PHE LEU HIS ILE GLY ASP          
SEQRES   2 C 2750  ILE CYS SER LEU TYR ALA GLU GLY SER THR ASN GLY PHE          
SEQRES   3 C 2750  ILE SER THR LEU GLY LEU VAL ASP ASP ARG CYS VAL VAL          
SEQRES   4 C 2750  GLN PRO GLU ALA GLY ASP LEU ASN ASN PRO PRO LYS LYS          
SEQRES   5 C 2750  PHE ARG ASP CYS LEU PHE LYS LEU CYS PRO MET ASN ARG          
SEQRES   6 C 2750  TYR SER ALA GLN LYS GLN PHE TRP LYS ALA ALA LYS PRO          
SEQRES   7 C 2750  GLY ALA ASN SER THR THR ASP ALA VAL LEU LEU ASN LYS          
SEQRES   8 C 2750  LEU HIS HIS ALA ALA ASP LEU GLU LYS LYS GLN ASN GLU          
SEQRES   9 C 2750  THR GLU ASN ARG LYS LEU LEU GLY THR VAL ILE GLN TYR          
SEQRES  10 C 2750  GLY ASN VAL ILE GLN LEU LEU HIS LEU LYS SER ASN LYS          
SEQRES  11 C 2750  TYR LEU THR VAL ASN LYS ARG LEU PRO ALA LEU LEU GLU          
SEQRES  12 C 2750  LYS ASN ALA MET ARG VAL THR LEU ASP GLU ALA GLY ASN          
SEQRES  13 C 2750  GLU GLY SER TRP PHE TYR ILE GLN PRO PHE TYR LYS LEU          
SEQRES  14 C 2750  ARG SER ILE GLY ASP SER VAL VAL ILE GLY ASP LYS VAL          
SEQRES  15 C 2750  VAL LEU ASN PRO VAL ASN ALA GLY GLN PRO LEU HIS ALA          
SEQRES  16 C 2750  SER SER HIS GLN LEU VAL ASP ASN PRO GLY CYS ASN GLU          
SEQRES  17 C 2750  VAL ASN SER VAL ASN CYS ASN THR SER TRP LYS ILE VAL          
SEQRES  18 C 2750  LEU PHE MET LYS TRP SER ASP ASN LYS ASP ASP ILE LEU          
SEQRES  19 C 2750  LYS GLY GLY ASP VAL VAL ARG LEU PHE HIS ALA GLU GLN          
SEQRES  20 C 2750  GLU LYS PHE LEU THR CYS ASP GLU HIS ARG LYS LYS GLN          
SEQRES  21 C 2750  HIS VAL PHE LEU ARG THR THR GLY ARG GLN SER ALA THR          
SEQRES  22 C 2750  SER ALA THR SER SER LYS ALA LEU TRP GLU VAL GLU VAL          
SEQRES  23 C 2750  VAL GLN HIS ASP PRO CYS ARG GLY GLY ALA GLY TYR TRP          
SEQRES  24 C 2750  ASN SER LEU PHE ARG PHE LYS HIS LEU ALA THR GLY HIS          
SEQRES  25 C 2750  TYR LEU ALA ALA GLU VAL ASP PRO ASP PHE GLU GLU GLU          
SEQRES  26 C 2750  CYS LEU GLU PHE GLN PRO SER VAL ASP PRO ASP GLN ASP          
SEQRES  27 C 2750  ALA SER ARG SER ARG LEU ARG ASN ALA GLN GLU LYS MET          
SEQRES  28 C 2750  VAL TYR SER LEU VAL SER VAL PRO GLU GLY ASN ASP ILE          
SEQRES  29 C 2750  SER SER ILE PHE GLU LEU ASP PRO THR THR LEU ARG GLY          
SEQRES  30 C 2750  GLY ASP SER LEU VAL PRO ARG ASN SER TYR VAL ARG LEU          
SEQRES  31 C 2750  ARG HIS LEU CYS THR ASN THR TRP VAL HIS SER THR ASN          
SEQRES  32 C 2750  ILE PRO ILE ASP LYS GLU GLU GLU LYS PRO VAL MET LEU          
SEQRES  33 C 2750  LYS ILE GLY THR SER PRO LEU LYS GLU ASP LYS GLU ALA          
SEQRES  34 C 2750  PHE ALA ILE VAL PRO VAL SER PRO ALA GLU VAL ARG ASP          
SEQRES  35 C 2750  LEU ASP PHE ALA ASN ASP ALA SER LYS VAL LEU GLY SER          
SEQRES  36 C 2750  ILE ALA GLY LYS LEU GLU LYS GLY THR ILE THR GLN ASN          
SEQRES  37 C 2750  GLU ARG ARG SER VAL THR LYS LEU LEU GLU ASP LEU VAL          
SEQRES  38 C 2750  TYR PHE VAL THR GLY GLY THR ASN SER GLY GLN ASP VAL          
SEQRES  39 C 2750  LEU GLU VAL VAL PHE SER LYS PRO ASN ARG GLU ARG GLN          
SEQRES  40 C 2750  LYS LEU MET ARG GLU GLN ASN ILE LEU LYS GLN ILE PHE          
SEQRES  41 C 2750  LYS LEU LEU GLN ALA PRO PHE THR ASP CYS GLY ASP GLY          
SEQRES  42 C 2750  PRO MET LEU ARG LEU GLU GLU LEU GLY ASP GLN ARG HIS          
SEQRES  43 C 2750  ALA PRO PHE ARG HIS ILE CYS ARG LEU CYS TYR ARG VAL          
SEQRES  44 C 2750  LEU ARG HIS SER GLN GLN ASP TYR ARG LYS ASN GLN GLU          
SEQRES  45 C 2750  TYR ILE ALA LYS GLN PHE GLY PHE MET GLN LYS GLN ILE          
SEQRES  46 C 2750  GLY TYR ASP VAL LEU ALA GLU ASP THR ILE THR ALA LEU          
SEQRES  47 C 2750  LEU HIS ASN ASN ARG LYS LEU LEU GLU LYS HIS ILE THR          
SEQRES  48 C 2750  ALA ALA GLU ILE ASP THR PHE VAL SER LEU VAL ARG LYS          
SEQRES  49 C 2750  ASN ARG GLU PRO ARG PHE LEU ASP TYR LEU SER ASP LEU          
SEQRES  50 C 2750  CYS VAL SER MET ASN LYS SER ILE PRO VAL THR GLN GLU          
SEQRES  51 C 2750  LEU ILE CYS LYS ALA VAL LEU ASN PRO THR ASN ALA ASP          
SEQRES  52 C 2750  ILE LEU ILE GLU THR LYS LEU VAL LEU SER ARG PHE GLU          
SEQRES  53 C 2750  PHE GLU GLY VAL SER THR GLY GLU ASN ALA LEU GLU ALA          
SEQRES  54 C 2750  GLY GLU ASP GLU GLU GLU VAL TRP LEU PHE TRP ARG ASP          
SEQRES  55 C 2750  SER ASN LYS GLU ILE ARG SER LYS SER VAL ARG GLU LEU          
SEQRES  56 C 2750  ALA GLN ASP ALA LYS GLU GLY GLN LYS GLU ASP ARG ASP          
SEQRES  57 C 2750  VAL LEU SER TYR TYR ARG TYR GLN LEU ASN LEU PHE ALA          
SEQRES  58 C 2750  ARG MET CYS LEU ASP ARG GLN TYR LEU ALA ILE ASN GLU          
SEQRES  59 C 2750  ILE SER GLY GLN LEU ASP VAL ASP LEU ILE LEU ARG CYS          
SEQRES  60 C 2750  MET SER ASP GLU ASN LEU PRO TYR ASP LEU ARG ALA SER          
SEQRES  61 C 2750  PHE CYS ARG LEU MET LEU HIS MET HIS VAL ASP ARG ASP          
SEQRES  62 C 2750  PRO GLN GLU GLN VAL THR PRO VAL LYS TYR ALA ARG LEU          
SEQRES  63 C 2750  TRP SER GLU ILE PRO SER GLU ILE ALA ILE ASP ASP TYR          
SEQRES  64 C 2750  ASP SER SER GLY ALA SER LYS ASP GLU ILE LYS GLU ARG          
SEQRES  65 C 2750  PHE ALA GLN THR MET GLU PHE VAL GLU GLU TYR LEU ARG          
SEQRES  66 C 2750  ASP VAL VAL CYS GLN ARG PHE PRO PHE SER ASP LYS GLU          
SEQRES  67 C 2750  LYS ASN LYS LEU THR PHE GLU VAL VAL ASN LEU ALA ARG          
SEQRES  68 C 2750  ASN LEU ILE TYR PHE GLY PHE TYR ASN PHE SER ASP LEU          
SEQRES  69 C 2750  LEU ARG LEU THR LYS ILE LEU LEU ALA ILE LEU ASP CYS          
SEQRES  70 C 2750  VAL HIS VAL THR THR ILE PHE PRO ILE SER LYS MET THR          
SEQRES  71 C 2750  LYS GLY GLU GLU ASN LYS GLY SER ASN VAL MET ARG SER          
SEQRES  72 C 2750  ILE HIS GLY VAL GLY GLU LEU MET THR GLN VAL VAL LEU          
SEQRES  73 C 2750  ARG GLY GLY GLY PHE LEU PRO MET THR PRO MET ALA ALA          
SEQRES  74 C 2750  ALA PRO GLU GLY ASN VAL LYS GLN ALA GLU PRO GLU LYS          
SEQRES  75 C 2750  GLU ASP ILE MET VAL MET ASP THR LYS LEU LYS ILE ILE          
SEQRES  76 C 2750  GLU ILE LEU GLN PHE ILE LEU ASN VAL ARG LEU ASP TYR          
SEQRES  77 C 2750  ARG ILE SER CYS LEU LEU CYS ILE PHE LYS ARG GLU PHE          
SEQRES  78 C 2750  ASP GLU SER ASN SER GLN SER SER GLU THR SER SER GLY          
SEQRES  79 C 2750  ASN SER SER GLN GLU GLY PRO SER ASN VAL PRO GLY ALA          
SEQRES  80 C 2750  LEU ASP PHE GLU HIS ILE GLU GLU GLN ALA GLU GLY ILE          
SEQRES  81 C 2750  PHE GLY GLY SER GLU GLU ASN THR PRO LEU ASP LEU ASP          
SEQRES  82 C 2750  ASP HIS GLY GLY ARG THR PHE LEU ARG VAL LEU LEU HIS          
SEQRES  83 C 2750  LEU THR MET HIS ASP TYR PRO PRO LEU VAL SER GLY ALA          
SEQRES  84 C 2750  LEU GLN LEU LEU PHE ARG HIS PHE SER GLN ARG GLN GLU          
SEQRES  85 C 2750  VAL LEU GLN ALA PHE LYS GLN VAL GLN LEU LEU VAL THR          
SEQRES  86 C 2750  SER GLN ASP VAL ASP ASN TYR LYS GLN ILE LYS GLN ASP          
SEQRES  87 C 2750  LEU ASP GLN LEU ARG SER ILE VAL GLU LYS SER GLU LEU          
SEQRES  88 C 2750  TRP VAL TYR LYS GLY GLN GLY PRO ASP GLU PRO MET ASP          
SEQRES  89 C 2750  GLY ALA SER GLY GLU ASN GLU HIS LYS LYS THR GLU GLU          
SEQRES  90 C 2750  GLY THR SER LYS PRO LEU LYS HIS GLU SER THR SER SER          
SEQRES  91 C 2750  TYR ASN TYR ARG VAL VAL LYS GLU ILE LEU ILE ARG LEU          
SEQRES  92 C 2750  SER LYS LEU CYS VAL GLN GLU SER ALA SER VAL ARG LYS          
SEQRES  93 C 2750  SER ARG LYS GLN GLN GLN ARG LEU LEU ARG ASN MET GLY          
SEQRES  94 C 2750  ALA HIS ALA VAL VAL LEU GLU LEU LEU GLN ILE PRO TYR          
SEQRES  95 C 2750  GLU LYS ALA GLU ASP THR LYS MET GLN GLU ILE MET ARG          
SEQRES  96 C 2750  LEU ALA HIS GLU PHE LEU GLN ASN PHE CYS ALA GLY ASN          
SEQRES  97 C 2750  GLN GLN ASN GLN ALA LEU LEU HIS LYS HIS ILE ASN LEU          
SEQRES  98 C 2750  PHE LEU ASN PRO GLY ILE LEU GLU ALA VAL THR MET GLN          
SEQRES  99 C 2750  HIS ILE PHE MET ASN ASN PHE GLN LEU CYS SER GLU ILE          
SEQRES 100 C 2750  ASN GLU ARG VAL VAL GLN HIS PHE VAL HIS CYS ILE GLU          
SEQRES 101 C 2750  THR HIS GLY ARG ASN VAL GLN TYR ILE LYS PHE LEU GLN          
SEQRES 102 C 2750  THR ILE VAL LYS ALA GLU GLY LYS PHE ILE LYS LYS CYS          
SEQRES 103 C 2750  GLN ASP MET VAL MET ALA GLU LEU VAL ASN SER GLY GLU          
SEQRES 104 C 2750  ASP VAL LEU VAL PHE TYR ASN ASP ARG ALA SER PHE GLN          
SEQRES 105 C 2750  THR LEU ILE GLN MET MET ARG SER GLU ARG ASP ARG MET          
SEQRES 106 C 2750  ASP GLU ASN SER PRO LEU PHE MET TYR HIS ILE HIS LEU          
SEQRES 107 C 2750  VAL GLU LEU LEU ALA VAL CYS THR GLU GLY LYS ASN VAL          
SEQRES 108 C 2750  TYR THR GLU ILE LYS CYS ASN SER LEU LEU PRO LEU ASP          
SEQRES 109 C 2750  ASP ILE VAL ARG VAL VAL THR HIS GLU ASP CYS ILE PRO          
SEQRES 110 C 2750  GLU VAL LYS ILE ALA TYR ILE ASN PHE LEU ASN HIS CYS          
SEQRES 111 C 2750  TYR VAL ASP THR GLU VAL GLU MET LYS GLU ILE TYR THR          
SEQRES 112 C 2750  SER ASN HIS MET TRP LYS LEU PHE GLU ASN PHE LEU VAL          
SEQRES 113 C 2750  ASP ILE CYS ARG ALA CYS ASN ASN THR SER ASP ARG LYS          
SEQRES 114 C 2750  HIS ALA ASP SER VAL LEU GLU LYS TYR VAL THR GLU ILE          
SEQRES 115 C 2750  VAL MET SER ILE VAL THR THR PHE PHE SER SER PRO PHE          
SEQRES 116 C 2750  SER ASP GLN SER THR THR LEU GLN THR ARG GLN PRO VAL          
SEQRES 117 C 2750  PHE VAL GLN LEU LEU GLN GLY VAL PHE ARG VAL TYR HIS          
SEQRES 118 C 2750  CYS ASN TRP LEU MET PRO SER GLN LYS ALA SER VAL GLU          
SEQRES 119 C 2750  SER CYS ILE ARG VAL LEU SER ASP VAL ALA LYS SER ARG          
SEQRES 120 C 2750  ALA ILE ALA ILE PRO VAL ASP LEU ASP SER GLN VAL ASN          
SEQRES 121 C 2750  ASN LEU PHE LEU LYS SER HIS ASN ILE VAL GLN LYS THR          
SEQRES 122 C 2750  ALA MET ASN TRP ARG LEU SER ALA ARG ASN ALA ALA ARG          
SEQRES 123 C 2750  ARG ASP SER VAL LEU ALA ALA SER ARG ASP TYR ARG ASN          
SEQRES 124 C 2750  ILE ILE GLU ARG LEU GLN ASP ILE VAL SER ALA LEU GLU          
SEQRES 125 C 2750  ASP ARG LEU ARG PRO LEU VAL GLN ALA GLU LEU SER VAL          
SEQRES 126 C 2750  LEU VAL ASP VAL LEU HIS ARG PRO GLU LEU LEU PHE PRO          
SEQRES 127 C 2750  GLU ASN THR ASP ALA ARG ARG LYS CYS GLU SER GLY GLY          
SEQRES 128 C 2750  PHE ILE CYS LYS LEU ILE LYS HIS THR LYS GLN LEU LEU          
SEQRES 129 C 2750  GLU GLU ASN GLU GLU LYS LEU CYS ILE LYS VAL LEU GLN          
SEQRES 130 C 2750  THR LEU ARG GLU MET MET THR LYS ASP ARG GLY TYR GLY          
SEQRES 131 C 2750  GLU LYS GLN ILE SER ILE ASP GLU LEU GLU ASN ALA GLU          
SEQRES 132 C 2750  LEU PRO GLN PRO PRO GLU ALA GLU ASN SER THR GLU GLN          
SEQRES 133 C 2750  GLU LEU GLU PRO SER PRO PRO LEU ARG GLN LEU GLU ASP          
SEQRES 134 C 2750  HIS LYS ARG GLY GLU ALA LEU ARG GLN ILE LEU VAL ASN          
SEQRES 135 C 2750  ARG TYR TYR GLY ASN ILE ARG PRO SER GLY ARG ARG GLU          
SEQRES 136 C 2750  SER LEU THR SER PHE GLY ASN GLY PRO LEU SER PRO GLY          
SEQRES 137 C 2750  GLY PRO SER LYS PRO GLY GLY GLY GLY GLY GLY PRO GLY          
SEQRES 138 C 2750  SER GLY SER THR SER ARG GLY GLU MET SER LEU ALA GLU          
SEQRES 139 C 2750  VAL GLN CYS HIS LEU ASP LYS GLU GLY ALA SER ASN LEU          
SEQRES 140 C 2750  VAL ILE ASP LEU ILE MET ASN ALA SER SER ASP ARG VAL          
SEQRES 141 C 2750  PHE HIS GLU SER ILE LEU LEU ALA ILE ALA LEU LEU GLU          
SEQRES 142 C 2750  GLY GLY ASN THR THR ILE GLN HIS SER PHE PHE CYS ARG          
SEQRES 143 C 2750  LEU THR GLU ASP LYS LYS SER GLU LYS PHE PHE LYS VAL          
SEQRES 144 C 2750  PHE TYR ASP ARG MET LYS VAL ALA GLN GLN GLU ILE LYS          
SEQRES 145 C 2750  ALA THR VAL THR VAL ASN THR SER ASP LEU GLY ASN LYS          
SEQRES 146 C 2750  LYS LYS ASP ASP GLU VAL ASP ARG ASP ALA PRO SER ARG          
SEQRES 147 C 2750  LYS LYS ALA LYS GLU PRO THR THR GLN ILE THR GLU GLU          
SEQRES 148 C 2750  VAL ARG ASP GLN LEU LEU GLU ALA SER ALA ALA THR ARG          
SEQRES 149 C 2750  LYS ALA PHE THR THR PHE ARG ARG GLU ALA ASP PRO ASP          
SEQRES 150 C 2750  ASP HIS TYR GLN SER GLY GLU GLY THR GLN ALA THR THR          
SEQRES 151 C 2750  ASP LYS ALA LYS ASP ASP LEU GLU MET SER ALA VAL ILE          
SEQRES 152 C 2750  THR ILE MET GLN PRO ILE LEU ARG PHE LEU GLN LEU LEU          
SEQRES 153 C 2750  CYS GLU ASN HIS ASN ARG ASP LEU GLN ASN PHE LEU ARG          
SEQRES 154 C 2750  CYS GLN ASN ASN LYS THR ASN TYR ASN LEU VAL CYS GLU          
SEQRES 155 C 2750  THR LEU GLN PHE LEU ASP CYS ILE CYS GLY SER THR THR          
SEQRES 156 C 2750  GLY GLY LEU GLY LEU LEU GLY LEU TYR ILE ASN GLU LYS          
SEQRES 157 C 2750  ASN VAL ALA LEU ILE ASN GLN THR LEU GLU SER LEU THR          
SEQRES 158 C 2750  GLU TYR CYS GLN GLY PRO CYS HIS GLU ASN GLN ASN CYS          
SEQRES 159 C 2750  ILE ALA THR HIS GLU SER ASN GLY ILE ASP ILE ILE THR          
SEQRES 160 C 2750  ALA LEU ILE LEU ASN ASP ILE ASN PRO LEU GLY LYS LYS          
SEQRES 161 C 2750  ARG MET ASP LEU VAL LEU GLU LEU LYS ASN ASN ALA SER          
SEQRES 162 C 2750  LYS LEU LEU LEU ALA ILE MET GLU SER ARG HIS ASP SER          
SEQRES 163 C 2750  GLU ASN ALA GLU ARG ILE LEU TYR ASN MET ARG PRO LYS          
SEQRES 164 C 2750  GLU LEU VAL GLU VAL ILE LYS LYS ALA TYR MET GLN GLY          
SEQRES 165 C 2750  GLU VAL GLU PHE GLU ASP GLY GLU ASN GLY GLU ASP GLY          
SEQRES 166 C 2750  ALA ALA SER PRO ARG ASN VAL GLY HIS ASN ILE TYR ILE          
SEQRES 167 C 2750  LEU ALA HIS GLN LEU ALA ARG HIS ASN LYS GLU LEU GLN          
SEQRES 168 C 2750  THR MET LEU LYS PRO GLY GLY GLN VAL ASP GLY ASP GLU          
SEQRES 169 C 2750  ALA LEU GLU PHE TYR ALA LYS HIS THR ALA GLN ILE GLU          
SEQRES 170 C 2750  ILE VAL ARG LEU ASP ARG THR MET GLU GLN ILE VAL PHE          
SEQRES 171 C 2750  PRO VAL PRO SER ILE CYS GLU PHE LEU THR LYS GLU SER          
SEQRES 172 C 2750  LYS LEU ARG ILE TYR TYR THR THR GLU ARG ASP GLU GLN          
SEQRES 173 C 2750  GLY SER LYS ILE ASN ASP PHE PHE LEU ARG SER GLU ASP          
SEQRES 174 C 2750  LEU PHE ASN GLU MET ASN TRP GLN LYS LYS LEU ARG ALA          
SEQRES 175 C 2750  GLN PRO VAL LEU TYR TRP CYS ALA ARG ASN MET SER PHE          
SEQRES 176 C 2750  TRP SER SER ILE SER PHE ASN LEU ALA VAL LEU MET ASN          
SEQRES 177 C 2750  LEU LEU VAL ALA PHE PHE TYR PRO PHE LYS GLY VAL ARG          
SEQRES 178 C 2750  GLY GLY THR LEU GLU PRO HIS TRP SER GLY LEU LEU TRP          
SEQRES 179 C 2750  THR ALA MET LEU ILE SER LEU ALA ILE VAL ILE ALA LEU          
SEQRES 180 C 2750  PRO LYS PRO HIS GLY ILE ARG ALA LEU ILE ALA SER THR          
SEQRES 181 C 2750  ILE LEU ARG LEU ILE PHE SER VAL GLY LEU GLN PRO THR          
SEQRES 182 C 2750  LEU PHE LEU LEU GLY ALA PHE ASN VAL CYS ASN LYS ILE          
SEQRES 183 C 2750  ILE PHE LEU MET SER PHE VAL GLY ASN CYS GLY THR PHE          
SEQRES 184 C 2750  THR ARG GLY TYR ARG ALA MET VAL LEU ASP VAL GLU PHE          
SEQRES 185 C 2750  LEU TYR HIS LEU LEU TYR LEU LEU ILE CYS ALA MET GLY          
SEQRES 186 C 2750  LEU PHE VAL HIS GLU PHE PHE TYR SER LEU LEU LEU PHE          
SEQRES 187 C 2750  ASP LEU VAL TYR ARG GLU GLU THR LEU LEU ASN VAL ILE          
SEQRES 188 C 2750  LYS SER VAL THR ARG ASN GLY ARG PRO ILE ILE LEU THR          
SEQRES 189 C 2750  ALA ALA LEU ALA LEU ILE LEU VAL TYR LEU PHE SER ILE          
SEQRES 190 C 2750  VAL GLY TYR LEU PHE PHE LYS ASP ASP PHE ILE LEU GLU          
SEQRES 191 C 2750  VAL ASP ARG LEU PRO ASN GLU THR ALA GLY PRO GLU THR          
SEQRES 192 C 2750  GLY GLU SER LEU ALA ASN ASP PHE LEU TYR SER ASP VAL          
SEQRES 193 C 2750  CYS ARG VAL GLU THR GLY GLU ASN CYS THR SER PRO ALA          
SEQRES 194 C 2750  PRO LYS GLU GLU LEU LEU PRO VAL GLU GLU THR GLU GLN          
SEQRES 195 C 2750  ASP LYS GLU HIS THR CYS GLU THR LEU LEU MET CYS ILE          
SEQRES 196 C 2750  VAL THR VAL LEU SER HIS GLY LEU ARG SER GLY GLY GLY          
SEQRES 197 C 2750  VAL GLY ASP VAL LEU ARG LYS PRO SER LYS GLU GLU PRO          
SEQRES 198 C 2750  LEU PHE ALA ALA ARG VAL ILE TYR ASP LEU LEU PHE PHE          
SEQRES 199 C 2750  PHE MET VAL ILE ILE ILE VAL LEU ASN LEU ILE PHE GLY          
SEQRES 200 C 2750  VAL ILE ILE ASP THR PHE ALA ASP LEU ARG SER GLU LYS          
SEQRES 201 C 2750  GLN LYS LYS GLU GLU ILE LEU LYS THR THR CYS PHE ILE          
SEQRES 202 C 2750  CYS GLY LEU GLU ARG ASP LYS PHE ASP ASN LYS THR VAL          
SEQRES 203 C 2750  THR PHE GLU GLU HIS ILE LYS GLU GLU HIS ASN MET TRP          
SEQRES 204 C 2750  HIS TYR LEU CYS PHE ILE VAL LEU VAL LYS VAL LYS ASP          
SEQRES 205 C 2750  SER THR GLU TYR THR GLY PRO GLU SER TYR VAL ALA GLU          
SEQRES 206 C 2750  MET ILE ARG GLU ARG ASN LEU ASP TRP PHE PRO ARG MET          
SEQRES 207 C 2750  ARG ALA MET SER LEU VAL SER SER ASP SER GLU GLY GLU          
SEQRES 208 C 2750  GLN ASN GLU LEU ARG ASN LEU GLN GLU LYS LEU GLU SER          
SEQRES 209 C 2750  THR MET LYS LEU VAL THR ASN LEU SER GLY GLN LEU SER          
SEQRES 210 C 2750  GLU LEU LYS ASP GLN MET THR GLU GLN ARG LYS GLN LYS          
SEQRES 211 C 2750  GLN ARG ILE GLY LEU LEU GLY HIS PRO PRO HIS MET ASN          
SEQRES 212 C 2750  VAL ASN PRO GLN GLN PRO ALA                                  
SEQRES   1 D 2750  MET SER ASP LYS MET SER SER PHE LEU HIS ILE GLY ASP          
SEQRES   2 D 2750  ILE CYS SER LEU TYR ALA GLU GLY SER THR ASN GLY PHE          
SEQRES   3 D 2750  ILE SER THR LEU GLY LEU VAL ASP ASP ARG CYS VAL VAL          
SEQRES   4 D 2750  GLN PRO GLU ALA GLY ASP LEU ASN ASN PRO PRO LYS LYS          
SEQRES   5 D 2750  PHE ARG ASP CYS LEU PHE LYS LEU CYS PRO MET ASN ARG          
SEQRES   6 D 2750  TYR SER ALA GLN LYS GLN PHE TRP LYS ALA ALA LYS PRO          
SEQRES   7 D 2750  GLY ALA ASN SER THR THR ASP ALA VAL LEU LEU ASN LYS          
SEQRES   8 D 2750  LEU HIS HIS ALA ALA ASP LEU GLU LYS LYS GLN ASN GLU          
SEQRES   9 D 2750  THR GLU ASN ARG LYS LEU LEU GLY THR VAL ILE GLN TYR          
SEQRES  10 D 2750  GLY ASN VAL ILE GLN LEU LEU HIS LEU LYS SER ASN LYS          
SEQRES  11 D 2750  TYR LEU THR VAL ASN LYS ARG LEU PRO ALA LEU LEU GLU          
SEQRES  12 D 2750  LYS ASN ALA MET ARG VAL THR LEU ASP GLU ALA GLY ASN          
SEQRES  13 D 2750  GLU GLY SER TRP PHE TYR ILE GLN PRO PHE TYR LYS LEU          
SEQRES  14 D 2750  ARG SER ILE GLY ASP SER VAL VAL ILE GLY ASP LYS VAL          
SEQRES  15 D 2750  VAL LEU ASN PRO VAL ASN ALA GLY GLN PRO LEU HIS ALA          
SEQRES  16 D 2750  SER SER HIS GLN LEU VAL ASP ASN PRO GLY CYS ASN GLU          
SEQRES  17 D 2750  VAL ASN SER VAL ASN CYS ASN THR SER TRP LYS ILE VAL          
SEQRES  18 D 2750  LEU PHE MET LYS TRP SER ASP ASN LYS ASP ASP ILE LEU          
SEQRES  19 D 2750  LYS GLY GLY ASP VAL VAL ARG LEU PHE HIS ALA GLU GLN          
SEQRES  20 D 2750  GLU LYS PHE LEU THR CYS ASP GLU HIS ARG LYS LYS GLN          
SEQRES  21 D 2750  HIS VAL PHE LEU ARG THR THR GLY ARG GLN SER ALA THR          
SEQRES  22 D 2750  SER ALA THR SER SER LYS ALA LEU TRP GLU VAL GLU VAL          
SEQRES  23 D 2750  VAL GLN HIS ASP PRO CYS ARG GLY GLY ALA GLY TYR TRP          
SEQRES  24 D 2750  ASN SER LEU PHE ARG PHE LYS HIS LEU ALA THR GLY HIS          
SEQRES  25 D 2750  TYR LEU ALA ALA GLU VAL ASP PRO ASP PHE GLU GLU GLU          
SEQRES  26 D 2750  CYS LEU GLU PHE GLN PRO SER VAL ASP PRO ASP GLN ASP          
SEQRES  27 D 2750  ALA SER ARG SER ARG LEU ARG ASN ALA GLN GLU LYS MET          
SEQRES  28 D 2750  VAL TYR SER LEU VAL SER VAL PRO GLU GLY ASN ASP ILE          
SEQRES  29 D 2750  SER SER ILE PHE GLU LEU ASP PRO THR THR LEU ARG GLY          
SEQRES  30 D 2750  GLY ASP SER LEU VAL PRO ARG ASN SER TYR VAL ARG LEU          
SEQRES  31 D 2750  ARG HIS LEU CYS THR ASN THR TRP VAL HIS SER THR ASN          
SEQRES  32 D 2750  ILE PRO ILE ASP LYS GLU GLU GLU LYS PRO VAL MET LEU          
SEQRES  33 D 2750  LYS ILE GLY THR SER PRO LEU LYS GLU ASP LYS GLU ALA          
SEQRES  34 D 2750  PHE ALA ILE VAL PRO VAL SER PRO ALA GLU VAL ARG ASP          
SEQRES  35 D 2750  LEU ASP PHE ALA ASN ASP ALA SER LYS VAL LEU GLY SER          
SEQRES  36 D 2750  ILE ALA GLY LYS LEU GLU LYS GLY THR ILE THR GLN ASN          
SEQRES  37 D 2750  GLU ARG ARG SER VAL THR LYS LEU LEU GLU ASP LEU VAL          
SEQRES  38 D 2750  TYR PHE VAL THR GLY GLY THR ASN SER GLY GLN ASP VAL          
SEQRES  39 D 2750  LEU GLU VAL VAL PHE SER LYS PRO ASN ARG GLU ARG GLN          
SEQRES  40 D 2750  LYS LEU MET ARG GLU GLN ASN ILE LEU LYS GLN ILE PHE          
SEQRES  41 D 2750  LYS LEU LEU GLN ALA PRO PHE THR ASP CYS GLY ASP GLY          
SEQRES  42 D 2750  PRO MET LEU ARG LEU GLU GLU LEU GLY ASP GLN ARG HIS          
SEQRES  43 D 2750  ALA PRO PHE ARG HIS ILE CYS ARG LEU CYS TYR ARG VAL          
SEQRES  44 D 2750  LEU ARG HIS SER GLN GLN ASP TYR ARG LYS ASN GLN GLU          
SEQRES  45 D 2750  TYR ILE ALA LYS GLN PHE GLY PHE MET GLN LYS GLN ILE          
SEQRES  46 D 2750  GLY TYR ASP VAL LEU ALA GLU ASP THR ILE THR ALA LEU          
SEQRES  47 D 2750  LEU HIS ASN ASN ARG LYS LEU LEU GLU LYS HIS ILE THR          
SEQRES  48 D 2750  ALA ALA GLU ILE ASP THR PHE VAL SER LEU VAL ARG LYS          
SEQRES  49 D 2750  ASN ARG GLU PRO ARG PHE LEU ASP TYR LEU SER ASP LEU          
SEQRES  50 D 2750  CYS VAL SER MET ASN LYS SER ILE PRO VAL THR GLN GLU          
SEQRES  51 D 2750  LEU ILE CYS LYS ALA VAL LEU ASN PRO THR ASN ALA ASP          
SEQRES  52 D 2750  ILE LEU ILE GLU THR LYS LEU VAL LEU SER ARG PHE GLU          
SEQRES  53 D 2750  PHE GLU GLY VAL SER THR GLY GLU ASN ALA LEU GLU ALA          
SEQRES  54 D 2750  GLY GLU ASP GLU GLU GLU VAL TRP LEU PHE TRP ARG ASP          
SEQRES  55 D 2750  SER ASN LYS GLU ILE ARG SER LYS SER VAL ARG GLU LEU          
SEQRES  56 D 2750  ALA GLN ASP ALA LYS GLU GLY GLN LYS GLU ASP ARG ASP          
SEQRES  57 D 2750  VAL LEU SER TYR TYR ARG TYR GLN LEU ASN LEU PHE ALA          
SEQRES  58 D 2750  ARG MET CYS LEU ASP ARG GLN TYR LEU ALA ILE ASN GLU          
SEQRES  59 D 2750  ILE SER GLY GLN LEU ASP VAL ASP LEU ILE LEU ARG CYS          
SEQRES  60 D 2750  MET SER ASP GLU ASN LEU PRO TYR ASP LEU ARG ALA SER          
SEQRES  61 D 2750  PHE CYS ARG LEU MET LEU HIS MET HIS VAL ASP ARG ASP          
SEQRES  62 D 2750  PRO GLN GLU GLN VAL THR PRO VAL LYS TYR ALA ARG LEU          
SEQRES  63 D 2750  TRP SER GLU ILE PRO SER GLU ILE ALA ILE ASP ASP TYR          
SEQRES  64 D 2750  ASP SER SER GLY ALA SER LYS ASP GLU ILE LYS GLU ARG          
SEQRES  65 D 2750  PHE ALA GLN THR MET GLU PHE VAL GLU GLU TYR LEU ARG          
SEQRES  66 D 2750  ASP VAL VAL CYS GLN ARG PHE PRO PHE SER ASP LYS GLU          
SEQRES  67 D 2750  LYS ASN LYS LEU THR PHE GLU VAL VAL ASN LEU ALA ARG          
SEQRES  68 D 2750  ASN LEU ILE TYR PHE GLY PHE TYR ASN PHE SER ASP LEU          
SEQRES  69 D 2750  LEU ARG LEU THR LYS ILE LEU LEU ALA ILE LEU ASP CYS          
SEQRES  70 D 2750  VAL HIS VAL THR THR ILE PHE PRO ILE SER LYS MET THR          
SEQRES  71 D 2750  LYS GLY GLU GLU ASN LYS GLY SER ASN VAL MET ARG SER          
SEQRES  72 D 2750  ILE HIS GLY VAL GLY GLU LEU MET THR GLN VAL VAL LEU          
SEQRES  73 D 2750  ARG GLY GLY GLY PHE LEU PRO MET THR PRO MET ALA ALA          
SEQRES  74 D 2750  ALA PRO GLU GLY ASN VAL LYS GLN ALA GLU PRO GLU LYS          
SEQRES  75 D 2750  GLU ASP ILE MET VAL MET ASP THR LYS LEU LYS ILE ILE          
SEQRES  76 D 2750  GLU ILE LEU GLN PHE ILE LEU ASN VAL ARG LEU ASP TYR          
SEQRES  77 D 2750  ARG ILE SER CYS LEU LEU CYS ILE PHE LYS ARG GLU PHE          
SEQRES  78 D 2750  ASP GLU SER ASN SER GLN SER SER GLU THR SER SER GLY          
SEQRES  79 D 2750  ASN SER SER GLN GLU GLY PRO SER ASN VAL PRO GLY ALA          
SEQRES  80 D 2750  LEU ASP PHE GLU HIS ILE GLU GLU GLN ALA GLU GLY ILE          
SEQRES  81 D 2750  PHE GLY GLY SER GLU GLU ASN THR PRO LEU ASP LEU ASP          
SEQRES  82 D 2750  ASP HIS GLY GLY ARG THR PHE LEU ARG VAL LEU LEU HIS          
SEQRES  83 D 2750  LEU THR MET HIS ASP TYR PRO PRO LEU VAL SER GLY ALA          
SEQRES  84 D 2750  LEU GLN LEU LEU PHE ARG HIS PHE SER GLN ARG GLN GLU          
SEQRES  85 D 2750  VAL LEU GLN ALA PHE LYS GLN VAL GLN LEU LEU VAL THR          
SEQRES  86 D 2750  SER GLN ASP VAL ASP ASN TYR LYS GLN ILE LYS GLN ASP          
SEQRES  87 D 2750  LEU ASP GLN LEU ARG SER ILE VAL GLU LYS SER GLU LEU          
SEQRES  88 D 2750  TRP VAL TYR LYS GLY GLN GLY PRO ASP GLU PRO MET ASP          
SEQRES  89 D 2750  GLY ALA SER GLY GLU ASN GLU HIS LYS LYS THR GLU GLU          
SEQRES  90 D 2750  GLY THR SER LYS PRO LEU LYS HIS GLU SER THR SER SER          
SEQRES  91 D 2750  TYR ASN TYR ARG VAL VAL LYS GLU ILE LEU ILE ARG LEU          
SEQRES  92 D 2750  SER LYS LEU CYS VAL GLN GLU SER ALA SER VAL ARG LYS          
SEQRES  93 D 2750  SER ARG LYS GLN GLN GLN ARG LEU LEU ARG ASN MET GLY          
SEQRES  94 D 2750  ALA HIS ALA VAL VAL LEU GLU LEU LEU GLN ILE PRO TYR          
SEQRES  95 D 2750  GLU LYS ALA GLU ASP THR LYS MET GLN GLU ILE MET ARG          
SEQRES  96 D 2750  LEU ALA HIS GLU PHE LEU GLN ASN PHE CYS ALA GLY ASN          
SEQRES  97 D 2750  GLN GLN ASN GLN ALA LEU LEU HIS LYS HIS ILE ASN LEU          
SEQRES  98 D 2750  PHE LEU ASN PRO GLY ILE LEU GLU ALA VAL THR MET GLN          
SEQRES  99 D 2750  HIS ILE PHE MET ASN ASN PHE GLN LEU CYS SER GLU ILE          
SEQRES 100 D 2750  ASN GLU ARG VAL VAL GLN HIS PHE VAL HIS CYS ILE GLU          
SEQRES 101 D 2750  THR HIS GLY ARG ASN VAL GLN TYR ILE LYS PHE LEU GLN          
SEQRES 102 D 2750  THR ILE VAL LYS ALA GLU GLY LYS PHE ILE LYS LYS CYS          
SEQRES 103 D 2750  GLN ASP MET VAL MET ALA GLU LEU VAL ASN SER GLY GLU          
SEQRES 104 D 2750  ASP VAL LEU VAL PHE TYR ASN ASP ARG ALA SER PHE GLN          
SEQRES 105 D 2750  THR LEU ILE GLN MET MET ARG SER GLU ARG ASP ARG MET          
SEQRES 106 D 2750  ASP GLU ASN SER PRO LEU PHE MET TYR HIS ILE HIS LEU          
SEQRES 107 D 2750  VAL GLU LEU LEU ALA VAL CYS THR GLU GLY LYS ASN VAL          
SEQRES 108 D 2750  TYR THR GLU ILE LYS CYS ASN SER LEU LEU PRO LEU ASP          
SEQRES 109 D 2750  ASP ILE VAL ARG VAL VAL THR HIS GLU ASP CYS ILE PRO          
SEQRES 110 D 2750  GLU VAL LYS ILE ALA TYR ILE ASN PHE LEU ASN HIS CYS          
SEQRES 111 D 2750  TYR VAL ASP THR GLU VAL GLU MET LYS GLU ILE TYR THR          
SEQRES 112 D 2750  SER ASN HIS MET TRP LYS LEU PHE GLU ASN PHE LEU VAL          
SEQRES 113 D 2750  ASP ILE CYS ARG ALA CYS ASN ASN THR SER ASP ARG LYS          
SEQRES 114 D 2750  HIS ALA ASP SER VAL LEU GLU LYS TYR VAL THR GLU ILE          
SEQRES 115 D 2750  VAL MET SER ILE VAL THR THR PHE PHE SER SER PRO PHE          
SEQRES 116 D 2750  SER ASP GLN SER THR THR LEU GLN THR ARG GLN PRO VAL          
SEQRES 117 D 2750  PHE VAL GLN LEU LEU GLN GLY VAL PHE ARG VAL TYR HIS          
SEQRES 118 D 2750  CYS ASN TRP LEU MET PRO SER GLN LYS ALA SER VAL GLU          
SEQRES 119 D 2750  SER CYS ILE ARG VAL LEU SER ASP VAL ALA LYS SER ARG          
SEQRES 120 D 2750  ALA ILE ALA ILE PRO VAL ASP LEU ASP SER GLN VAL ASN          
SEQRES 121 D 2750  ASN LEU PHE LEU LYS SER HIS ASN ILE VAL GLN LYS THR          
SEQRES 122 D 2750  ALA MET ASN TRP ARG LEU SER ALA ARG ASN ALA ALA ARG          
SEQRES 123 D 2750  ARG ASP SER VAL LEU ALA ALA SER ARG ASP TYR ARG ASN          
SEQRES 124 D 2750  ILE ILE GLU ARG LEU GLN ASP ILE VAL SER ALA LEU GLU          
SEQRES 125 D 2750  ASP ARG LEU ARG PRO LEU VAL GLN ALA GLU LEU SER VAL          
SEQRES 126 D 2750  LEU VAL ASP VAL LEU HIS ARG PRO GLU LEU LEU PHE PRO          
SEQRES 127 D 2750  GLU ASN THR ASP ALA ARG ARG LYS CYS GLU SER GLY GLY          
SEQRES 128 D 2750  PHE ILE CYS LYS LEU ILE LYS HIS THR LYS GLN LEU LEU          
SEQRES 129 D 2750  GLU GLU ASN GLU GLU LYS LEU CYS ILE LYS VAL LEU GLN          
SEQRES 130 D 2750  THR LEU ARG GLU MET MET THR LYS ASP ARG GLY TYR GLY          
SEQRES 131 D 2750  GLU LYS GLN ILE SER ILE ASP GLU LEU GLU ASN ALA GLU          
SEQRES 132 D 2750  LEU PRO GLN PRO PRO GLU ALA GLU ASN SER THR GLU GLN          
SEQRES 133 D 2750  GLU LEU GLU PRO SER PRO PRO LEU ARG GLN LEU GLU ASP          
SEQRES 134 D 2750  HIS LYS ARG GLY GLU ALA LEU ARG GLN ILE LEU VAL ASN          
SEQRES 135 D 2750  ARG TYR TYR GLY ASN ILE ARG PRO SER GLY ARG ARG GLU          
SEQRES 136 D 2750  SER LEU THR SER PHE GLY ASN GLY PRO LEU SER PRO GLY          
SEQRES 137 D 2750  GLY PRO SER LYS PRO GLY GLY GLY GLY GLY GLY PRO GLY          
SEQRES 138 D 2750  SER GLY SER THR SER ARG GLY GLU MET SER LEU ALA GLU          
SEQRES 139 D 2750  VAL GLN CYS HIS LEU ASP LYS GLU GLY ALA SER ASN LEU          
SEQRES 140 D 2750  VAL ILE ASP LEU ILE MET ASN ALA SER SER ASP ARG VAL          
SEQRES 141 D 2750  PHE HIS GLU SER ILE LEU LEU ALA ILE ALA LEU LEU GLU          
SEQRES 142 D 2750  GLY GLY ASN THR THR ILE GLN HIS SER PHE PHE CYS ARG          
SEQRES 143 D 2750  LEU THR GLU ASP LYS LYS SER GLU LYS PHE PHE LYS VAL          
SEQRES 144 D 2750  PHE TYR ASP ARG MET LYS VAL ALA GLN GLN GLU ILE LYS          
SEQRES 145 D 2750  ALA THR VAL THR VAL ASN THR SER ASP LEU GLY ASN LYS          
SEQRES 146 D 2750  LYS LYS ASP ASP GLU VAL ASP ARG ASP ALA PRO SER ARG          
SEQRES 147 D 2750  LYS LYS ALA LYS GLU PRO THR THR GLN ILE THR GLU GLU          
SEQRES 148 D 2750  VAL ARG ASP GLN LEU LEU GLU ALA SER ALA ALA THR ARG          
SEQRES 149 D 2750  LYS ALA PHE THR THR PHE ARG ARG GLU ALA ASP PRO ASP          
SEQRES 150 D 2750  ASP HIS TYR GLN SER GLY GLU GLY THR GLN ALA THR THR          
SEQRES 151 D 2750  ASP LYS ALA LYS ASP ASP LEU GLU MET SER ALA VAL ILE          
SEQRES 152 D 2750  THR ILE MET GLN PRO ILE LEU ARG PHE LEU GLN LEU LEU          
SEQRES 153 D 2750  CYS GLU ASN HIS ASN ARG ASP LEU GLN ASN PHE LEU ARG          
SEQRES 154 D 2750  CYS GLN ASN ASN LYS THR ASN TYR ASN LEU VAL CYS GLU          
SEQRES 155 D 2750  THR LEU GLN PHE LEU ASP CYS ILE CYS GLY SER THR THR          
SEQRES 156 D 2750  GLY GLY LEU GLY LEU LEU GLY LEU TYR ILE ASN GLU LYS          
SEQRES 157 D 2750  ASN VAL ALA LEU ILE ASN GLN THR LEU GLU SER LEU THR          
SEQRES 158 D 2750  GLU TYR CYS GLN GLY PRO CYS HIS GLU ASN GLN ASN CYS          
SEQRES 159 D 2750  ILE ALA THR HIS GLU SER ASN GLY ILE ASP ILE ILE THR          
SEQRES 160 D 2750  ALA LEU ILE LEU ASN ASP ILE ASN PRO LEU GLY LYS LYS          
SEQRES 161 D 2750  ARG MET ASP LEU VAL LEU GLU LEU LYS ASN ASN ALA SER          
SEQRES 162 D 2750  LYS LEU LEU LEU ALA ILE MET GLU SER ARG HIS ASP SER          
SEQRES 163 D 2750  GLU ASN ALA GLU ARG ILE LEU TYR ASN MET ARG PRO LYS          
SEQRES 164 D 2750  GLU LEU VAL GLU VAL ILE LYS LYS ALA TYR MET GLN GLY          
SEQRES 165 D 2750  GLU VAL GLU PHE GLU ASP GLY GLU ASN GLY GLU ASP GLY          
SEQRES 166 D 2750  ALA ALA SER PRO ARG ASN VAL GLY HIS ASN ILE TYR ILE          
SEQRES 167 D 2750  LEU ALA HIS GLN LEU ALA ARG HIS ASN LYS GLU LEU GLN          
SEQRES 168 D 2750  THR MET LEU LYS PRO GLY GLY GLN VAL ASP GLY ASP GLU          
SEQRES 169 D 2750  ALA LEU GLU PHE TYR ALA LYS HIS THR ALA GLN ILE GLU          
SEQRES 170 D 2750  ILE VAL ARG LEU ASP ARG THR MET GLU GLN ILE VAL PHE          
SEQRES 171 D 2750  PRO VAL PRO SER ILE CYS GLU PHE LEU THR LYS GLU SER          
SEQRES 172 D 2750  LYS LEU ARG ILE TYR TYR THR THR GLU ARG ASP GLU GLN          
SEQRES 173 D 2750  GLY SER LYS ILE ASN ASP PHE PHE LEU ARG SER GLU ASP          
SEQRES 174 D 2750  LEU PHE ASN GLU MET ASN TRP GLN LYS LYS LEU ARG ALA          
SEQRES 175 D 2750  GLN PRO VAL LEU TYR TRP CYS ALA ARG ASN MET SER PHE          
SEQRES 176 D 2750  TRP SER SER ILE SER PHE ASN LEU ALA VAL LEU MET ASN          
SEQRES 177 D 2750  LEU LEU VAL ALA PHE PHE TYR PRO PHE LYS GLY VAL ARG          
SEQRES 178 D 2750  GLY GLY THR LEU GLU PRO HIS TRP SER GLY LEU LEU TRP          
SEQRES 179 D 2750  THR ALA MET LEU ILE SER LEU ALA ILE VAL ILE ALA LEU          
SEQRES 180 D 2750  PRO LYS PRO HIS GLY ILE ARG ALA LEU ILE ALA SER THR          
SEQRES 181 D 2750  ILE LEU ARG LEU ILE PHE SER VAL GLY LEU GLN PRO THR          
SEQRES 182 D 2750  LEU PHE LEU LEU GLY ALA PHE ASN VAL CYS ASN LYS ILE          
SEQRES 183 D 2750  ILE PHE LEU MET SER PHE VAL GLY ASN CYS GLY THR PHE          
SEQRES 184 D 2750  THR ARG GLY TYR ARG ALA MET VAL LEU ASP VAL GLU PHE          
SEQRES 185 D 2750  LEU TYR HIS LEU LEU TYR LEU LEU ILE CYS ALA MET GLY          
SEQRES 186 D 2750  LEU PHE VAL HIS GLU PHE PHE TYR SER LEU LEU LEU PHE          
SEQRES 187 D 2750  ASP LEU VAL TYR ARG GLU GLU THR LEU LEU ASN VAL ILE          
SEQRES 188 D 2750  LYS SER VAL THR ARG ASN GLY ARG PRO ILE ILE LEU THR          
SEQRES 189 D 2750  ALA ALA LEU ALA LEU ILE LEU VAL TYR LEU PHE SER ILE          
SEQRES 190 D 2750  VAL GLY TYR LEU PHE PHE LYS ASP ASP PHE ILE LEU GLU          
SEQRES 191 D 2750  VAL ASP ARG LEU PRO ASN GLU THR ALA GLY PRO GLU THR          
SEQRES 192 D 2750  GLY GLU SER LEU ALA ASN ASP PHE LEU TYR SER ASP VAL          
SEQRES 193 D 2750  CYS ARG VAL GLU THR GLY GLU ASN CYS THR SER PRO ALA          
SEQRES 194 D 2750  PRO LYS GLU GLU LEU LEU PRO VAL GLU GLU THR GLU GLN          
SEQRES 195 D 2750  ASP LYS GLU HIS THR CYS GLU THR LEU LEU MET CYS ILE          
SEQRES 196 D 2750  VAL THR VAL LEU SER HIS GLY LEU ARG SER GLY GLY GLY          
SEQRES 197 D 2750  VAL GLY ASP VAL LEU ARG LYS PRO SER LYS GLU GLU PRO          
SEQRES 198 D 2750  LEU PHE ALA ALA ARG VAL ILE TYR ASP LEU LEU PHE PHE          
SEQRES 199 D 2750  PHE MET VAL ILE ILE ILE VAL LEU ASN LEU ILE PHE GLY          
SEQRES 200 D 2750  VAL ILE ILE ASP THR PHE ALA ASP LEU ARG SER GLU LYS          
SEQRES 201 D 2750  GLN LYS LYS GLU GLU ILE LEU LYS THR THR CYS PHE ILE          
SEQRES 202 D 2750  CYS GLY LEU GLU ARG ASP LYS PHE ASP ASN LYS THR VAL          
SEQRES 203 D 2750  THR PHE GLU GLU HIS ILE LYS GLU GLU HIS ASN MET TRP          
SEQRES 204 D 2750  HIS TYR LEU CYS PHE ILE VAL LEU VAL LYS VAL LYS ASP          
SEQRES 205 D 2750  SER THR GLU TYR THR GLY PRO GLU SER TYR VAL ALA GLU          
SEQRES 206 D 2750  MET ILE ARG GLU ARG ASN LEU ASP TRP PHE PRO ARG MET          
SEQRES 207 D 2750  ARG ALA MET SER LEU VAL SER SER ASP SER GLU GLY GLU          
SEQRES 208 D 2750  GLN ASN GLU LEU ARG ASN LEU GLN GLU LYS LEU GLU SER          
SEQRES 209 D 2750  THR MET LYS LEU VAL THR ASN LEU SER GLY GLN LEU SER          
SEQRES 210 D 2750  GLU LEU LYS ASP GLN MET THR GLU GLN ARG LYS GLN LYS          
SEQRES 211 D 2750  GLN ARG ILE GLY LEU LEU GLY HIS PRO PRO HIS MET ASN          
SEQRES 212 D 2750  VAL ASN PRO GLN GLN PRO ALA                                  
HELIX    1   1 LYS A   52  LEU A   57  1                                   6    
HELIX    2   2 SER A   67  ALA A   75  1                                   9    
HELIX    3   3 ASP A   85  LYS A  109  1                                  25    
HELIX    4   4 LYS A  235  VAL A  239  5                                   5    
HELIX    5   5 THR A  266  GLN A  270  5                                   5    
HELIX    6   6 SER A  436  GLU A  461  1                                  26    
HELIX    7   7 THR A  466  THR A  485  1                                  20    
HELIX    8   8 VAL A  494  LYS A  501  1                                   8    
HELIX    9   9 ARG A  506  GLN A  513  1                                   8    
HELIX   10  10 ASN A  514  ALA A  525  1                                  12    
HELIX   11  11 PRO A  534  GLN A  544  1                                  11    
HELIX   12  12 ALA A  547  GLN A  564  1                                  18    
HELIX   13  13 TYR A  567  GLN A  571  5                                   5    
HELIX   14  14 ILE A  574  PHE A  580  1                                   7    
HELIX   15  15 SER A 2274  PHE A 2293  1                                  20    
HELIX   16  16 LEU A 2312  ILE A 2319  1                                   8    
HELIX   17  17 SER A 2320  ILE A 2325  5                                   6    
HELIX   18  18 LEU A 2327  SER A 2347  1                                  21    
HELIX   19  19 PHE A 2355  GLY A 2377  1                                  23    
HELIX   20  20 PHE A 2411  LEU A 2427  1                                  17    
HELIX   21  21 ASN A 2429  ARG A 2439  1                                  11    
HELIX   22  22 ILE A 2441  VAL A 2458  1                                  18    
HELIX   23  23 GLU A 2513  GLN A 2522  1                                  10    
HELIX   24  24 THR A 2530  SER A 2545  1                                  16    
HELIX   25  25 PRO A 2561  LYS A 2600  1                                  40    
HELIX   26  26 VAL A 2684  ARG A 2732  1                                  49    
HELIX   27  27 LYS B   52  LEU B   57  1                                   6    
HELIX   28  28 SER B   67  ALA B   75  1                                   9    
HELIX   29  29 ASP B   85  LYS B  109  1                                  25    
HELIX   30  30 LYS B  235  VAL B  239  5                                   5    
HELIX   31  31 THR B  266  GLN B  270  5                                   5    
HELIX   32  32 SER B  436  GLU B  461  1                                  26    
HELIX   33  33 THR B  466  THR B  485  1                                  20    
HELIX   34  34 VAL B  494  LYS B  501  1                                   8    
HELIX   35  35 ARG B  506  GLN B  513  1                                   8    
HELIX   36  36 ASN B  514  ALA B  525  1                                  12    
HELIX   37  37 PRO B  534  GLN B  544  1                                  11    
HELIX   38  38 ALA B  547  GLN B  564  1                                  18    
HELIX   39  39 TYR B  567  GLN B  571  5                                   5    
HELIX   40  40 ILE B  574  PHE B  580  1                                   7    
HELIX   41  41 SER B 2274  PHE B 2293  1                                  20    
HELIX   42  42 LEU B 2312  ILE B 2319  1                                   8    
HELIX   43  43 SER B 2320  ILE B 2325  5                                   6    
HELIX   44  44 LEU B 2327  SER B 2347  1                                  21    
HELIX   45  45 PHE B 2355  GLY B 2377  1                                  23    
HELIX   46  46 PHE B 2411  LEU B 2427  1                                  17    
HELIX   47  47 ASN B 2429  ARG B 2439  1                                  11    
HELIX   48  48 ILE B 2441  VAL B 2458  1                                  18    
HELIX   49  49 GLU B 2513  GLN B 2522  1                                  10    
HELIX   50  50 THR B 2530  SER B 2545  1                                  16    
HELIX   51  51 PRO B 2561  LYS B 2600  1                                  40    
HELIX   52  52 VAL B 2684  ARG B 2732  1                                  49    
HELIX   53  53 LYS C   52  LEU C   57  1                                   6    
HELIX   54  54 SER C   67  ALA C   75  1                                   9    
HELIX   55  55 ASP C   85  LYS C  109  1                                  25    
HELIX   56  56 LYS C  235  VAL C  239  5                                   5    
HELIX   57  57 THR C  266  GLN C  270  5                                   5    
HELIX   58  58 SER C  436  GLU C  461  1                                  26    
HELIX   59  59 THR C  466  THR C  485  1                                  20    
HELIX   60  60 VAL C  494  LYS C  501  1                                   8    
HELIX   61  61 ARG C  506  GLN C  513  1                                   8    
HELIX   62  62 ASN C  514  ALA C  525  1                                  12    
HELIX   63  63 PRO C  534  GLN C  544  1                                  11    
HELIX   64  64 ALA C  547  GLN C  564  1                                  18    
HELIX   65  65 TYR C  567  GLN C  571  5                                   5    
HELIX   66  66 ILE C  574  PHE C  580  1                                   7    
HELIX   67  67 SER C 2274  PHE C 2293  1                                  20    
HELIX   68  68 LEU C 2312  ILE C 2319  1                                   8    
HELIX   69  69 SER C 2320  ILE C 2325  5                                   6    
HELIX   70  70 LEU C 2327  SER C 2347  1                                  21    
HELIX   71  71 PHE C 2355  GLY C 2377  1                                  23    
HELIX   72  72 PHE C 2411  LEU C 2427  1                                  17    
HELIX   73  73 ASN C 2429  ARG C 2439  1                                  11    
HELIX   74  74 ILE C 2441  VAL C 2458  1                                  18    
HELIX   75  75 GLU C 2513  GLN C 2522  1                                  10    
HELIX   76  76 THR C 2530  SER C 2545  1                                  16    
HELIX   77  77 PRO C 2561  LYS C 2600  1                                  40    
HELIX   78  78 VAL C 2684  ARG C 2732  1                                  49    
HELIX   79  79 LYS D   52  LEU D   57  1                                   6    
HELIX   80  80 SER D   67  ALA D   75  1                                   9    
HELIX   81  81 ASP D   85  LYS D  109  1                                  25    
HELIX   82  82 LYS D  235  VAL D  239  5                                   5    
HELIX   83  83 THR D  266  GLN D  270  5                                   5    
HELIX   84  84 SER D  436  GLU D  461  1                                  26    
HELIX   85  85 THR D  466  THR D  485  1                                  20    
HELIX   86  86 VAL D  494  LYS D  501  1                                   8    
HELIX   87  87 ARG D  506  GLN D  513  1                                   8    
HELIX   88  88 ASN D  514  ALA D  525  1                                  12    
HELIX   89  89 PRO D  534  GLN D  544  1                                  11    
HELIX   90  90 ALA D  547  GLN D  564  1                                  18    
HELIX   91  91 TYR D  567  GLN D  571  5                                   5    
HELIX   92  92 ILE D  574  PHE D  580  1                                   7    
HELIX   93  93 SER D 2274  PHE D 2293  1                                  20    
HELIX   94  94 LEU D 2312  ILE D 2319  1                                   8    
HELIX   95  95 SER D 2320  ILE D 2325  5                                   6    
HELIX   96  96 LEU D 2327  SER D 2347  1                                  21    
HELIX   97  97 PHE D 2355  GLY D 2377  1                                  23    
HELIX   98  98 PHE D 2411  LEU D 2427  1                                  17    
HELIX   99  99 LEU D 2428  ARG D 2439  1                                  12    
HELIX  100 100 ILE D 2441  VAL D 2458  1                                  18    
HELIX  101 101 GLU D 2513  GLN D 2522  1                                  10    
HELIX  102 102 THR D 2530  SER D 2545  1                                  16    
HELIX  103 103 PRO D 2561  LYS D 2600  1                                  40    
HELIX  104 104 VAL D 2684  ARG D 2732  1                                  49    
SHEET    1   A 2 LYS A  59  LEU A  60  0                                        
SHEET    2   A 2 LEU A 123  LEU A 124 -1  O  LEU A 124   N  LYS A  59           
SHEET    1   B 2 THR A 252  GLU A 255  0                                        
SHEET    2   B 2 GLN A 260  PHE A 263 -1  O  HIS A 261   N  ASP A 254           
SHEET    1   C 2 GLU A 369  ASP A 371  0                                        
SHEET    2   C 2 ARG A 389  ARG A 391 -1  O  ARG A 389   N  ASP A 371           
SHEET    1   D 2 LYS B  59  LEU B  60  0                                        
SHEET    2   D 2 LEU B 123  LEU B 124 -1  O  LEU B 124   N  LYS B  59           
SHEET    1   E 2 THR B 252  GLU B 255  0                                        
SHEET    2   E 2 GLN B 260  PHE B 263 -1  O  PHE B 263   N  THR B 252           
SHEET    1   F 2 GLU B 369  ASP B 371  0                                        
SHEET    2   F 2 ARG B 389  ARG B 391 -1  O  ARG B 389   N  ASP B 371           
SHEET    1   G 2 LYS C  59  LEU C  60  0                                        
SHEET    2   G 2 LEU C 123  LEU C 124 -1  O  LEU C 124   N  LYS C  59           
SHEET    1   H 2 THR C 252  GLU C 255  0                                        
SHEET    2   H 2 GLN C 260  PHE C 263 -1  O  HIS C 261   N  ASP C 254           
SHEET    1   I 2 GLU C 369  ASP C 371  0                                        
SHEET    2   I 2 ARG C 389  ARG C 391 -1  O  ARG C 389   N  ASP C 371           
SHEET    1   J 2 LYS D  59  LEU D  60  0                                        
SHEET    2   J 2 LEU D 123  LEU D 124 -1  O  LEU D 124   N  LYS D  59           
SHEET    1   K 2 THR D 252  GLU D 255  0                                        
SHEET    2   K 2 GLN D 260  PHE D 263 -1  O  PHE D 263   N  THR D 252           
SHEET    1   L 2 GLU D 369  ASP D 371  0                                        
SHEET    2   L 2 ARG D 389  ARG D 391 -1  O  ARG D 389   N  ASP D 371           
CISPEP   1 SER A   22    THR A   23          0        -4.84                     
CISPEP   2 LEU A   32    VAL A   33          0       -27.21                     
CISPEP   3 VAL A   33    ASP A   34          0         2.79                     
CISPEP   4 ALA A   80    ASN A   81          0       -22.55                     
CISPEP   5 VAL A  134    ASN A  135          0         9.87                     
CISPEP   6 SER A  159    TRP A  160          0        -8.85                     
CISPEP   7 ALA A  189    GLY A  190          0        -4.80                     
CISPEP   8 GLN A  191    PRO A  192          0        12.97                     
CISPEP   9 LYS A  230    ASP A  231          0        -9.40                     
CISPEP  10 ALA A  280    LEU A  281          0        -4.21                     
CISPEP  11 GLN A  288    HIS A  289          0       -12.94                     
CISPEP  12 LEU A  308    ALA A  309          0       -10.05                     
CISPEP  13 ALA A  309    THR A  310          0         8.83                     
CISPEP  14 PRO A  359    GLU A  360          0        -1.76                     
CISPEP  15 THR A  397    TRP A  398          0       -14.57                     
CISPEP  16 GLU A  410    GLU A  411          0         2.09                     
CISPEP  17 LYS A  412    PRO A  413          0       -20.84                     
CISPEP  18 ASN A  489    SER A  490          0        -1.14                     
CISPEP  19 THR A  528    ASP A  529          0        -4.19                     
CISPEP  20 ASP A  532    GLY A  533          0        -1.41                     
CISPEP  21 GLY A  533    PRO A  534          0        -3.35                     
CISPEP  22 GLU A 2306    PRO A 2307          0        -6.32                     
CISPEP  23 THR A 2353    LEU A 2354          0        -7.84                     
CISPEP  24 PHE A 2463    LYS A 2464          0        14.54                     
CISPEP  25 THR A 2527    CYS A 2528          0        -5.83                     
CISPEP  26 GLU A 2529    THR A 2530          0        11.16                     
CISPEP  27 GLY A 2546    GLY A 2547          0        -4.88                     
CISPEP  28 VAL A 2552    LEU A 2553          0        27.88                     
CISPEP  29 SER B   22    THR B   23          0        -4.31                     
CISPEP  30 LEU B   32    VAL B   33          0       -27.26                     
CISPEP  31 VAL B   33    ASP B   34          0         2.88                     
CISPEP  32 ALA B   80    ASN B   81          0       -22.43                     
CISPEP  33 VAL B  134    ASN B  135          0         9.84                     
CISPEP  34 SER B  159    TRP B  160          0        -9.18                     
CISPEP  35 ALA B  189    GLY B  190          0        -4.58                     
CISPEP  36 GLN B  191    PRO B  192          0        13.43                     
CISPEP  37 LYS B  230    ASP B  231          0        -9.02                     
CISPEP  38 ALA B  280    LEU B  281          0        -4.25                     
CISPEP  39 GLN B  288    HIS B  289          0       -11.92                     
CISPEP  40 LEU B  308    ALA B  309          0       -10.91                     
CISPEP  41 ALA B  309    THR B  310          0         8.68                     
CISPEP  42 PRO B  359    GLU B  360          0        -2.27                     
CISPEP  43 THR B  397    TRP B  398          0       -13.60                     
CISPEP  44 GLU B  410    GLU B  411          0         2.44                     
CISPEP  45 LYS B  412    PRO B  413          0       -20.85                     
CISPEP  46 ASN B  489    SER B  490          0        -0.69                     
CISPEP  47 THR B  528    ASP B  529          0        -4.14                     
CISPEP  48 ASP B  532    GLY B  533          0        -1.51                     
CISPEP  49 GLY B  533    PRO B  534          0        -3.54                     
CISPEP  50 GLU B 2306    PRO B 2307          0        -5.68                     
CISPEP  51 THR B 2353    LEU B 2354          0        -7.68                     
CISPEP  52 PHE B 2463    LYS B 2464          0        14.49                     
CISPEP  53 THR B 2527    CYS B 2528          0        -5.84                     
CISPEP  54 GLU B 2529    THR B 2530          0        11.49                     
CISPEP  55 GLY B 2546    GLY B 2547          0        -4.91                     
CISPEP  56 VAL B 2552    LEU B 2553          0        26.75                     
CISPEP  57 SER C   22    THR C   23          0        -4.88                     
CISPEP  58 LEU C   32    VAL C   33          0       -27.41                     
CISPEP  59 VAL C   33    ASP C   34          0         2.75                     
CISPEP  60 ALA C   80    ASN C   81          0       -22.54                     
CISPEP  61 VAL C  134    ASN C  135          0         9.88                     
CISPEP  62 SER C  159    TRP C  160          0        -8.90                     
CISPEP  63 ALA C  189    GLY C  190          0        -4.84                     
CISPEP  64 GLN C  191    PRO C  192          0        13.00                     
CISPEP  65 LYS C  230    ASP C  231          0        -9.46                     
CISPEP  66 ALA C  280    LEU C  281          0        -4.27                     
CISPEP  67 GLN C  288    HIS C  289          0       -12.89                     
CISPEP  68 LEU C  308    ALA C  309          0       -10.12                     
CISPEP  69 ALA C  309    THR C  310          0         8.79                     
CISPEP  70 PRO C  359    GLU C  360          0        -1.67                     
CISPEP  71 THR C  397    TRP C  398          0       -14.61                     
CISPEP  72 GLU C  410    GLU C  411          0         2.20                     
CISPEP  73 LYS C  412    PRO C  413          0       -20.35                     
CISPEP  74 ASN C  489    SER C  490          0        -1.11                     
CISPEP  75 THR C  528    ASP C  529          0        -4.18                     
CISPEP  76 ASP C  532    GLY C  533          0        -1.53                     
CISPEP  77 GLY C  533    PRO C  534          0        -3.34                     
CISPEP  78 GLU C 2306    PRO C 2307          0        -6.38                     
CISPEP  79 THR C 2353    LEU C 2354          0        -7.80                     
CISPEP  80 PHE C 2463    LYS C 2464          0        14.64                     
CISPEP  81 THR C 2527    CYS C 2528          0        -5.90                     
CISPEP  82 GLU C 2529    THR C 2530          0        11.25                     
CISPEP  83 GLY C 2546    GLY C 2547          0        -4.83                     
CISPEP  84 VAL C 2552    LEU C 2553          0        28.07                     
CISPEP  85 SER D   22    THR D   23          0        -4.38                     
CISPEP  86 LEU D   32    VAL D   33          0       -27.31                     
CISPEP  87 VAL D   33    ASP D   34          0         2.95                     
CISPEP  88 ALA D   80    ASN D   81          0       -22.43                     
CISPEP  89 VAL D  134    ASN D  135          0         9.85                     
CISPEP  90 SER D  159    TRP D  160          0        -9.29                     
CISPEP  91 ALA D  189    GLY D  190          0        -4.51                     
CISPEP  92 GLN D  191    PRO D  192          0        13.36                     
CISPEP  93 LYS D  230    ASP D  231          0        -8.92                     
CISPEP  94 ALA D  280    LEU D  281          0        -4.29                     
CISPEP  95 GLN D  288    HIS D  289          0       -11.99                     
CISPEP  96 LEU D  308    ALA D  309          0       -10.95                     
CISPEP  97 ALA D  309    THR D  310          0         8.65                     
CISPEP  98 PRO D  359    GLU D  360          0        -2.10                     
CISPEP  99 THR D  397    TRP D  398          0       -13.36                     
CISPEP 100 GLU D  410    GLU D  411          0         2.48                     
CISPEP 101 LYS D  412    PRO D  413          0       -21.00                     
CISPEP 102 ASN D  489    SER D  490          0        -0.66                     
CISPEP 103 THR D  528    ASP D  529          0        -4.24                     
CISPEP 104 ASP D  532    GLY D  533          0        -1.49                     
CISPEP 105 GLY D  533    PRO D  534          0        -3.58                     
CISPEP 106 GLU D 2306    PRO D 2307          0        -5.86                     
CISPEP 107 THR D 2353    LEU D 2354          0        -7.68                     
CISPEP 108 PHE D 2463    LYS D 2464          0        14.53                     
CISPEP 109 THR D 2527    CYS D 2528          0        -5.86                     
CISPEP 110 GLU D 2529    THR D 2530          0        11.55                     
CISPEP 111 GLY D 2546    GLY D 2547          0        -4.75                     
CISPEP 112 VAL D 2552    LEU D 2553          0        26.73                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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