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Database: PDB
Entry: 3JBT
LinkDB: 3JBT
Original site: 3JBT 
HEADER    APOPTOSIS                               15-OCT-15   3JBT              
TITLE     ATOMIC STRUCTURE OF THE APAF-1 APOPTOSOME                             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: APOPTOTIC PROTEASE-ACTIVATING FACTOR 1;                    
COMPND   3 CHAIN: A, C, E, G, I, K, M;                                          
COMPND   4 SYNONYM: APAF-1;                                                     
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: CYTOCHROME C;                                              
COMPND   8 CHAIN: B, D, F, H, J, L, N                                           
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: APAF1, KIAA0413;                                               
SOURCE   6 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE   7 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE  10 MOL_ID: 2;                                                           
SOURCE  11 ORGANISM_SCIENTIFIC: EQUUS CABALLUS;                                 
SOURCE  12 ORGANISM_COMMON: HORSE;                                              
SOURCE  13 ORGANISM_TAXID: 9796                                                 
KEYWDS    APOPTOSOME, CRYO-EM STRUCTURE, APOPTOSIS, APAF-1                      
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    M.ZHOU,Y.LI,Q.HU,X.BAI,W.HUANG,C.YAN,S.H.W.SCHERES,Y.SHI              
REVDAT   4   18-DEC-19 3JBT    1       REMARK SEQADV SCALE                      
REVDAT   3   16-OCT-19 3JBT    1       REMARK CRYST1                            
REVDAT   2   18-JAN-17 3JBT    1       JRNL                                     
REVDAT   1   18-NOV-15 3JBT    0                                                
JRNL        AUTH   M.ZHOU,Y.LI,Q.HU,X.C.BAI,W.HUANG,C.YAN,S.H.W.SCHERES,Y.SHI   
JRNL        TITL   ATOMIC STRUCTURE OF THE APOPTOSOME: MECHANISM OF CYTOCHROME  
JRNL        TITL 2 C- AND DATP-MEDIATED ACTIVATION OF APAF-1                    
JRNL        REF    GENES DEV.                    V.  29  2349 2015              
JRNL        REFN                   ISSN 1549-5477                               
JRNL        PMID   26543158                                                     
JRNL        DOI    10.1101/GAD.272278.115                                       
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.80 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : UCSF CHIMERA, RELION                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : 3J2T                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : RIGID BODY FIT                      
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : REFINEMENT PROTOCOL--RIGID BODY                  
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.800                          
REMARK   3   NUMBER OF PARTICLES               : 134919                         
REMARK   3   CTF CORRECTION METHOD             : NULL                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: (SINGLE PARTICLE--APPLIED SYMMETRY: C7)               
REMARK   4                                                                      
REMARK   4 3JBT COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ.                               
REMARK 100 THE DEPOSITION ID IS D_1000160503.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : HEPTAMERIC APOPTOSOME OF          
REMARK 245                                    ACTIVATED HUMAN APAF-1 BINDING    
REMARK 245                                    TO HORSE CYTOCHROME C AND DATP;   
REMARK 245                                    THE APOPTOTIC PROTEASE            
REMARK 245                                    ACTIVATING FACTOR 1; CYTOCHROME   
REMARK 245                                    C                                 
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 5.00                              
REMARK 245   SAMPLE SUPPORT DETAILS         : 400-MESH CU R 1.2/1.3 GRIDS       
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : 20 MM HEPES (PH 7.5), 10 MM       
REMARK 245                                    KCL, 1.5 MM MGCL2, 1 MM EDTA, 1   
REMARK 245                                    MM DTT                            
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : HEPTAMER                          
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : 10-JAN-15                      
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 (4K X 4K)             
REMARK 245   MINIMUM DEFOCUS (NM)              : 1400.00                        
REMARK 245   MAXIMUM DEFOCUS (NM)              : 3000.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : 0.00                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : 0.00                           
REMARK 245   NOMINAL CS                        : 2.00                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 40.00                          
REMARK 245   ILLUMINATION MODE                 : SPOT SCAN                      
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRADECAMERIC                    
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: K, L, M, N                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ASP A     2                                                      
REMARK 465     ALA A     3                                                      
REMARK 465     LYS A     4                                                      
REMARK 465     ALA A     5                                                      
REMARK 465     ARG A     6                                                      
REMARK 465     ASN A     7                                                      
REMARK 465     CYS A     8                                                      
REMARK 465     LEU A     9                                                      
REMARK 465     LEU A    10                                                      
REMARK 465     GLN A    11                                                      
REMARK 465     HIS A    12                                                      
REMARK 465     ARG A    13                                                      
REMARK 465     GLU A    14                                                      
REMARK 465     ALA A    15                                                      
REMARK 465     LEU A    16                                                      
REMARK 465     GLU A    17                                                      
REMARK 465     LYS A    18                                                      
REMARK 465     ASP A    19                                                      
REMARK 465     ILE A    20                                                      
REMARK 465     LYS A    21                                                      
REMARK 465     THR A    22                                                      
REMARK 465     SER A    23                                                      
REMARK 465     TYR A    24                                                      
REMARK 465     ILE A    25                                                      
REMARK 465     MET A    26                                                      
REMARK 465     ASP A    27                                                      
REMARK 465     HIS A    28                                                      
REMARK 465     MET A    29                                                      
REMARK 465     ILE A    30                                                      
REMARK 465     SER A    31                                                      
REMARK 465     ASP A    32                                                      
REMARK 465     GLY A    33                                                      
REMARK 465     PHE A    34                                                      
REMARK 465     LEU A    35                                                      
REMARK 465     THR A    36                                                      
REMARK 465     ILE A    37                                                      
REMARK 465     SER A    38                                                      
REMARK 465     GLU A    39                                                      
REMARK 465     GLU A    40                                                      
REMARK 465     GLU A    41                                                      
REMARK 465     LYS A    42                                                      
REMARK 465     VAL A    43                                                      
REMARK 465     ARG A    44                                                      
REMARK 465     ASN A    45                                                      
REMARK 465     GLU A    46                                                      
REMARK 465     PRO A    47                                                      
REMARK 465     THR A    48                                                      
REMARK 465     GLN A    49                                                      
REMARK 465     GLN A    50                                                      
REMARK 465     GLN A    51                                                      
REMARK 465     ARG A    52                                                      
REMARK 465     ALA A    53                                                      
REMARK 465     ALA A    54                                                      
REMARK 465     MET A    55                                                      
REMARK 465     LEU A    56                                                      
REMARK 465     ILE A    57                                                      
REMARK 465     LYS A    58                                                      
REMARK 465     MET A    59                                                      
REMARK 465     ILE A    60                                                      
REMARK 465     LEU A    61                                                      
REMARK 465     LYS A    62                                                      
REMARK 465     LYS A    63                                                      
REMARK 465     ASP A    64                                                      
REMARK 465     ASN A    65                                                      
REMARK 465     ASP A    66                                                      
REMARK 465     SER A    67                                                      
REMARK 465     TYR A    68                                                      
REMARK 465     VAL A    69                                                      
REMARK 465     SER A    70                                                      
REMARK 465     PHE A    71                                                      
REMARK 465     TYR A    72                                                      
REMARK 465     ASN A    73                                                      
REMARK 465     ALA A    74                                                      
REMARK 465     LEU A    75                                                      
REMARK 465     LEU A    76                                                      
REMARK 465     HIS A    77                                                      
REMARK 465     GLU A    78                                                      
REMARK 465     GLY A    79                                                      
REMARK 465     TYR A    80                                                      
REMARK 465     LYS A    81                                                      
REMARK 465     ASP A    82                                                      
REMARK 465     LEU A    83                                                      
REMARK 465     ALA A    84                                                      
REMARK 465     ALA A    85                                                      
REMARK 465     LEU A    86                                                      
REMARK 465     LEU A    87                                                      
REMARK 465     HIS A    88                                                      
REMARK 465     ASP A    89                                                      
REMARK 465     GLY A    90                                                      
REMARK 465     ILE A    91                                                      
REMARK 465     PRO A    92                                                      
REMARK 465     VAL A    93                                                      
REMARK 465     VAL A    94                                                      
REMARK 465     SER A    95                                                      
REMARK 465     SER A    96                                                      
REMARK 465     SER A    97                                                      
REMARK 465     SER A    98                                                      
REMARK 465     GLY A    99                                                      
REMARK 465     LYS A   100                                                      
REMARK 465     ASP A   101                                                      
REMARK 465     SER A   102                                                      
REMARK 465     VAL A   103                                                      
REMARK 465     SER A   104                                                      
REMARK 465     LEU A  1249                                                      
REMARK 465     GLU A  1250                                                      
REMARK 465     HIS A  1251                                                      
REMARK 465     HIS A  1252                                                      
REMARK 465     HIS A  1253                                                      
REMARK 465     HIS A  1254                                                      
REMARK 465     HIS A  1255                                                      
REMARK 465     HIS A  1256                                                      
REMARK 465     HIS A  1257                                                      
REMARK 465     HIS A  1258                                                      
REMARK 465     HIS A  1259                                                      
REMARK 465     HIS A  1260                                                      
REMARK 465     MET B     0                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ASP C     2                                                      
REMARK 465     ALA C     3                                                      
REMARK 465     LYS C     4                                                      
REMARK 465     ALA C     5                                                      
REMARK 465     ARG C     6                                                      
REMARK 465     ASN C     7                                                      
REMARK 465     CYS C     8                                                      
REMARK 465     LEU C     9                                                      
REMARK 465     LEU C    10                                                      
REMARK 465     GLN C    11                                                      
REMARK 465     HIS C    12                                                      
REMARK 465     ARG C    13                                                      
REMARK 465     GLU C    14                                                      
REMARK 465     ALA C    15                                                      
REMARK 465     LEU C    16                                                      
REMARK 465     GLU C    17                                                      
REMARK 465     LYS C    18                                                      
REMARK 465     ASP C    19                                                      
REMARK 465     ILE C    20                                                      
REMARK 465     LYS C    21                                                      
REMARK 465     THR C    22                                                      
REMARK 465     SER C    23                                                      
REMARK 465     TYR C    24                                                      
REMARK 465     ILE C    25                                                      
REMARK 465     MET C    26                                                      
REMARK 465     ASP C    27                                                      
REMARK 465     HIS C    28                                                      
REMARK 465     MET C    29                                                      
REMARK 465     ILE C    30                                                      
REMARK 465     SER C    31                                                      
REMARK 465     ASP C    32                                                      
REMARK 465     GLY C    33                                                      
REMARK 465     PHE C    34                                                      
REMARK 465     LEU C    35                                                      
REMARK 465     THR C    36                                                      
REMARK 465     ILE C    37                                                      
REMARK 465     SER C    38                                                      
REMARK 465     GLU C    39                                                      
REMARK 465     GLU C    40                                                      
REMARK 465     GLU C    41                                                      
REMARK 465     LYS C    42                                                      
REMARK 465     VAL C    43                                                      
REMARK 465     ARG C    44                                                      
REMARK 465     ASN C    45                                                      
REMARK 465     GLU C    46                                                      
REMARK 465     PRO C    47                                                      
REMARK 465     THR C    48                                                      
REMARK 465     GLN C    49                                                      
REMARK 465     GLN C    50                                                      
REMARK 465     GLN C    51                                                      
REMARK 465     ARG C    52                                                      
REMARK 465     ALA C    53                                                      
REMARK 465     ALA C    54                                                      
REMARK 465     MET C    55                                                      
REMARK 465     LEU C    56                                                      
REMARK 465     ILE C    57                                                      
REMARK 465     LYS C    58                                                      
REMARK 465     MET C    59                                                      
REMARK 465     ILE C    60                                                      
REMARK 465     LEU C    61                                                      
REMARK 465     LYS C    62                                                      
REMARK 465     LYS C    63                                                      
REMARK 465     ASP C    64                                                      
REMARK 465     ASN C    65                                                      
REMARK 465     ASP C    66                                                      
REMARK 465     SER C    67                                                      
REMARK 465     TYR C    68                                                      
REMARK 465     VAL C    69                                                      
REMARK 465     SER C    70                                                      
REMARK 465     PHE C    71                                                      
REMARK 465     TYR C    72                                                      
REMARK 465     ASN C    73                                                      
REMARK 465     ALA C    74                                                      
REMARK 465     LEU C    75                                                      
REMARK 465     LEU C    76                                                      
REMARK 465     HIS C    77                                                      
REMARK 465     GLU C    78                                                      
REMARK 465     GLY C    79                                                      
REMARK 465     TYR C    80                                                      
REMARK 465     LYS C    81                                                      
REMARK 465     ASP C    82                                                      
REMARK 465     LEU C    83                                                      
REMARK 465     ALA C    84                                                      
REMARK 465     ALA C    85                                                      
REMARK 465     LEU C    86                                                      
REMARK 465     LEU C    87                                                      
REMARK 465     HIS C    88                                                      
REMARK 465     ASP C    89                                                      
REMARK 465     GLY C    90                                                      
REMARK 465     ILE C    91                                                      
REMARK 465     PRO C    92                                                      
REMARK 465     VAL C    93                                                      
REMARK 465     VAL C    94                                                      
REMARK 465     SER C    95                                                      
REMARK 465     SER C    96                                                      
REMARK 465     SER C    97                                                      
REMARK 465     SER C    98                                                      
REMARK 465     GLY C    99                                                      
REMARK 465     LYS C   100                                                      
REMARK 465     ASP C   101                                                      
REMARK 465     SER C   102                                                      
REMARK 465     VAL C   103                                                      
REMARK 465     SER C   104                                                      
REMARK 465     LEU C  1249                                                      
REMARK 465     GLU C  1250                                                      
REMARK 465     HIS C  1251                                                      
REMARK 465     HIS C  1252                                                      
REMARK 465     HIS C  1253                                                      
REMARK 465     HIS C  1254                                                      
REMARK 465     HIS C  1255                                                      
REMARK 465     HIS C  1256                                                      
REMARK 465     HIS C  1257                                                      
REMARK 465     HIS C  1258                                                      
REMARK 465     HIS C  1259                                                      
REMARK 465     HIS C  1260                                                      
REMARK 465     MET D     0                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ASP E     2                                                      
REMARK 465     ALA E     3                                                      
REMARK 465     LYS E     4                                                      
REMARK 465     ALA E     5                                                      
REMARK 465     ARG E     6                                                      
REMARK 465     ASN E     7                                                      
REMARK 465     CYS E     8                                                      
REMARK 465     LEU E     9                                                      
REMARK 465     LEU E    10                                                      
REMARK 465     GLN E    11                                                      
REMARK 465     HIS E    12                                                      
REMARK 465     ARG E    13                                                      
REMARK 465     GLU E    14                                                      
REMARK 465     ALA E    15                                                      
REMARK 465     LEU E    16                                                      
REMARK 465     GLU E    17                                                      
REMARK 465     LYS E    18                                                      
REMARK 465     ASP E    19                                                      
REMARK 465     ILE E    20                                                      
REMARK 465     LYS E    21                                                      
REMARK 465     THR E    22                                                      
REMARK 465     SER E    23                                                      
REMARK 465     TYR E    24                                                      
REMARK 465     ILE E    25                                                      
REMARK 465     MET E    26                                                      
REMARK 465     ASP E    27                                                      
REMARK 465     HIS E    28                                                      
REMARK 465     MET E    29                                                      
REMARK 465     ILE E    30                                                      
REMARK 465     SER E    31                                                      
REMARK 465     ASP E    32                                                      
REMARK 465     GLY E    33                                                      
REMARK 465     PHE E    34                                                      
REMARK 465     LEU E    35                                                      
REMARK 465     THR E    36                                                      
REMARK 465     ILE E    37                                                      
REMARK 465     SER E    38                                                      
REMARK 465     GLU E    39                                                      
REMARK 465     GLU E    40                                                      
REMARK 465     GLU E    41                                                      
REMARK 465     LYS E    42                                                      
REMARK 465     VAL E    43                                                      
REMARK 465     ARG E    44                                                      
REMARK 465     ASN E    45                                                      
REMARK 465     GLU E    46                                                      
REMARK 465     PRO E    47                                                      
REMARK 465     THR E    48                                                      
REMARK 465     GLN E    49                                                      
REMARK 465     GLN E    50                                                      
REMARK 465     GLN E    51                                                      
REMARK 465     ARG E    52                                                      
REMARK 465     ALA E    53                                                      
REMARK 465     ALA E    54                                                      
REMARK 465     MET E    55                                                      
REMARK 465     LEU E    56                                                      
REMARK 465     ILE E    57                                                      
REMARK 465     LYS E    58                                                      
REMARK 465     MET E    59                                                      
REMARK 465     ILE E    60                                                      
REMARK 465     LEU E    61                                                      
REMARK 465     LYS E    62                                                      
REMARK 465     LYS E    63                                                      
REMARK 465     ASP E    64                                                      
REMARK 465     ASN E    65                                                      
REMARK 465     ASP E    66                                                      
REMARK 465     SER E    67                                                      
REMARK 465     TYR E    68                                                      
REMARK 465     VAL E    69                                                      
REMARK 465     SER E    70                                                      
REMARK 465     PHE E    71                                                      
REMARK 465     TYR E    72                                                      
REMARK 465     ASN E    73                                                      
REMARK 465     ALA E    74                                                      
REMARK 465     LEU E    75                                                      
REMARK 465     LEU E    76                                                      
REMARK 465     HIS E    77                                                      
REMARK 465     GLU E    78                                                      
REMARK 465     GLY E    79                                                      
REMARK 465     TYR E    80                                                      
REMARK 465     LYS E    81                                                      
REMARK 465     ASP E    82                                                      
REMARK 465     LEU E    83                                                      
REMARK 465     ALA E    84                                                      
REMARK 465     ALA E    85                                                      
REMARK 465     LEU E    86                                                      
REMARK 465     LEU E    87                                                      
REMARK 465     HIS E    88                                                      
REMARK 465     ASP E    89                                                      
REMARK 465     GLY E    90                                                      
REMARK 465     ILE E    91                                                      
REMARK 465     PRO E    92                                                      
REMARK 465     VAL E    93                                                      
REMARK 465     VAL E    94                                                      
REMARK 465     SER E    95                                                      
REMARK 465     SER E    96                                                      
REMARK 465     SER E    97                                                      
REMARK 465     SER E    98                                                      
REMARK 465     GLY E    99                                                      
REMARK 465     LYS E   100                                                      
REMARK 465     ASP E   101                                                      
REMARK 465     SER E   102                                                      
REMARK 465     VAL E   103                                                      
REMARK 465     SER E   104                                                      
REMARK 465     LEU E  1249                                                      
REMARK 465     GLU E  1250                                                      
REMARK 465     HIS E  1251                                                      
REMARK 465     HIS E  1252                                                      
REMARK 465     HIS E  1253                                                      
REMARK 465     HIS E  1254                                                      
REMARK 465     HIS E  1255                                                      
REMARK 465     HIS E  1256                                                      
REMARK 465     HIS E  1257                                                      
REMARK 465     HIS E  1258                                                      
REMARK 465     HIS E  1259                                                      
REMARK 465     HIS E  1260                                                      
REMARK 465     MET F     0                                                      
REMARK 465     MET G     1                                                      
REMARK 465     ASP G     2                                                      
REMARK 465     ALA G     3                                                      
REMARK 465     LYS G     4                                                      
REMARK 465     ALA G     5                                                      
REMARK 465     ARG G     6                                                      
REMARK 465     ASN G     7                                                      
REMARK 465     CYS G     8                                                      
REMARK 465     LEU G     9                                                      
REMARK 465     LEU G    10                                                      
REMARK 465     GLN G    11                                                      
REMARK 465     HIS G    12                                                      
REMARK 465     ARG G    13                                                      
REMARK 465     GLU G    14                                                      
REMARK 465     ALA G    15                                                      
REMARK 465     LEU G    16                                                      
REMARK 465     GLU G    17                                                      
REMARK 465     LYS G    18                                                      
REMARK 465     ASP G    19                                                      
REMARK 465     ILE G    20                                                      
REMARK 465     LYS G    21                                                      
REMARK 465     THR G    22                                                      
REMARK 465     SER G    23                                                      
REMARK 465     TYR G    24                                                      
REMARK 465     ILE G    25                                                      
REMARK 465     MET G    26                                                      
REMARK 465     ASP G    27                                                      
REMARK 465     HIS G    28                                                      
REMARK 465     MET G    29                                                      
REMARK 465     ILE G    30                                                      
REMARK 465     SER G    31                                                      
REMARK 465     ASP G    32                                                      
REMARK 465     GLY G    33                                                      
REMARK 465     PHE G    34                                                      
REMARK 465     LEU G    35                                                      
REMARK 465     THR G    36                                                      
REMARK 465     ILE G    37                                                      
REMARK 465     SER G    38                                                      
REMARK 465     GLU G    39                                                      
REMARK 465     GLU G    40                                                      
REMARK 465     GLU G    41                                                      
REMARK 465     LYS G    42                                                      
REMARK 465     VAL G    43                                                      
REMARK 465     ARG G    44                                                      
REMARK 465     ASN G    45                                                      
REMARK 465     GLU G    46                                                      
REMARK 465     PRO G    47                                                      
REMARK 465     THR G    48                                                      
REMARK 465     GLN G    49                                                      
REMARK 465     GLN G    50                                                      
REMARK 465     GLN G    51                                                      
REMARK 465     ARG G    52                                                      
REMARK 465     ALA G    53                                                      
REMARK 465     ALA G    54                                                      
REMARK 465     MET G    55                                                      
REMARK 465     LEU G    56                                                      
REMARK 465     ILE G    57                                                      
REMARK 465     LYS G    58                                                      
REMARK 465     MET G    59                                                      
REMARK 465     ILE G    60                                                      
REMARK 465     LEU G    61                                                      
REMARK 465     LYS G    62                                                      
REMARK 465     LYS G    63                                                      
REMARK 465     ASP G    64                                                      
REMARK 465     ASN G    65                                                      
REMARK 465     ASP G    66                                                      
REMARK 465     SER G    67                                                      
REMARK 465     TYR G    68                                                      
REMARK 465     VAL G    69                                                      
REMARK 465     SER G    70                                                      
REMARK 465     PHE G    71                                                      
REMARK 465     TYR G    72                                                      
REMARK 465     ASN G    73                                                      
REMARK 465     ALA G    74                                                      
REMARK 465     LEU G    75                                                      
REMARK 465     LEU G    76                                                      
REMARK 465     HIS G    77                                                      
REMARK 465     GLU G    78                                                      
REMARK 465     GLY G    79                                                      
REMARK 465     TYR G    80                                                      
REMARK 465     LYS G    81                                                      
REMARK 465     ASP G    82                                                      
REMARK 465     LEU G    83                                                      
REMARK 465     ALA G    84                                                      
REMARK 465     ALA G    85                                                      
REMARK 465     LEU G    86                                                      
REMARK 465     LEU G    87                                                      
REMARK 465     HIS G    88                                                      
REMARK 465     ASP G    89                                                      
REMARK 465     GLY G    90                                                      
REMARK 465     ILE G    91                                                      
REMARK 465     PRO G    92                                                      
REMARK 465     VAL G    93                                                      
REMARK 465     VAL G    94                                                      
REMARK 465     SER G    95                                                      
REMARK 465     SER G    96                                                      
REMARK 465     SER G    97                                                      
REMARK 465     SER G    98                                                      
REMARK 465     GLY G    99                                                      
REMARK 465     LYS G   100                                                      
REMARK 465     ASP G   101                                                      
REMARK 465     SER G   102                                                      
REMARK 465     VAL G   103                                                      
REMARK 465     SER G   104                                                      
REMARK 465     LEU G  1249                                                      
REMARK 465     GLU G  1250                                                      
REMARK 465     HIS G  1251                                                      
REMARK 465     HIS G  1252                                                      
REMARK 465     HIS G  1253                                                      
REMARK 465     HIS G  1254                                                      
REMARK 465     HIS G  1255                                                      
REMARK 465     HIS G  1256                                                      
REMARK 465     HIS G  1257                                                      
REMARK 465     HIS G  1258                                                      
REMARK 465     HIS G  1259                                                      
REMARK 465     HIS G  1260                                                      
REMARK 465     MET H     0                                                      
REMARK 465     MET I     1                                                      
REMARK 465     ASP I     2                                                      
REMARK 465     ALA I     3                                                      
REMARK 465     LYS I     4                                                      
REMARK 465     ALA I     5                                                      
REMARK 465     ARG I     6                                                      
REMARK 465     ASN I     7                                                      
REMARK 465     CYS I     8                                                      
REMARK 465     LEU I     9                                                      
REMARK 465     LEU I    10                                                      
REMARK 465     GLN I    11                                                      
REMARK 465     HIS I    12                                                      
REMARK 465     ARG I    13                                                      
REMARK 465     GLU I    14                                                      
REMARK 465     ALA I    15                                                      
REMARK 465     LEU I    16                                                      
REMARK 465     GLU I    17                                                      
REMARK 465     LYS I    18                                                      
REMARK 465     ASP I    19                                                      
REMARK 465     ILE I    20                                                      
REMARK 465     LYS I    21                                                      
REMARK 465     THR I    22                                                      
REMARK 465     SER I    23                                                      
REMARK 465     TYR I    24                                                      
REMARK 465     ILE I    25                                                      
REMARK 465     MET I    26                                                      
REMARK 465     ASP I    27                                                      
REMARK 465     HIS I    28                                                      
REMARK 465     MET I    29                                                      
REMARK 465     ILE I    30                                                      
REMARK 465     SER I    31                                                      
REMARK 465     ASP I    32                                                      
REMARK 465     GLY I    33                                                      
REMARK 465     PHE I    34                                                      
REMARK 465     LEU I    35                                                      
REMARK 465     THR I    36                                                      
REMARK 465     ILE I    37                                                      
REMARK 465     SER I    38                                                      
REMARK 465     GLU I    39                                                      
REMARK 465     GLU I    40                                                      
REMARK 465     GLU I    41                                                      
REMARK 465     LYS I    42                                                      
REMARK 465     VAL I    43                                                      
REMARK 465     ARG I    44                                                      
REMARK 465     ASN I    45                                                      
REMARK 465     GLU I    46                                                      
REMARK 465     PRO I    47                                                      
REMARK 465     THR I    48                                                      
REMARK 465     GLN I    49                                                      
REMARK 465     GLN I    50                                                      
REMARK 465     GLN I    51                                                      
REMARK 465     ARG I    52                                                      
REMARK 465     ALA I    53                                                      
REMARK 465     ALA I    54                                                      
REMARK 465     MET I    55                                                      
REMARK 465     LEU I    56                                                      
REMARK 465     ILE I    57                                                      
REMARK 465     LYS I    58                                                      
REMARK 465     MET I    59                                                      
REMARK 465     ILE I    60                                                      
REMARK 465     LEU I    61                                                      
REMARK 465     LYS I    62                                                      
REMARK 465     LYS I    63                                                      
REMARK 465     ASP I    64                                                      
REMARK 465     ASN I    65                                                      
REMARK 465     ASP I    66                                                      
REMARK 465     SER I    67                                                      
REMARK 465     TYR I    68                                                      
REMARK 465     VAL I    69                                                      
REMARK 465     SER I    70                                                      
REMARK 465     PHE I    71                                                      
REMARK 465     TYR I    72                                                      
REMARK 465     ASN I    73                                                      
REMARK 465     ALA I    74                                                      
REMARK 465     LEU I    75                                                      
REMARK 465     LEU I    76                                                      
REMARK 465     HIS I    77                                                      
REMARK 465     GLU I    78                                                      
REMARK 465     GLY I    79                                                      
REMARK 465     TYR I    80                                                      
REMARK 465     LYS I    81                                                      
REMARK 465     ASP I    82                                                      
REMARK 465     LEU I    83                                                      
REMARK 465     ALA I    84                                                      
REMARK 465     ALA I    85                                                      
REMARK 465     LEU I    86                                                      
REMARK 465     LEU I    87                                                      
REMARK 465     HIS I    88                                                      
REMARK 465     ASP I    89                                                      
REMARK 465     GLY I    90                                                      
REMARK 465     ILE I    91                                                      
REMARK 465     PRO I    92                                                      
REMARK 465     VAL I    93                                                      
REMARK 465     VAL I    94                                                      
REMARK 465     SER I    95                                                      
REMARK 465     SER I    96                                                      
REMARK 465     SER I    97                                                      
REMARK 465     SER I    98                                                      
REMARK 465     GLY I    99                                                      
REMARK 465     LYS I   100                                                      
REMARK 465     ASP I   101                                                      
REMARK 465     SER I   102                                                      
REMARK 465     VAL I   103                                                      
REMARK 465     SER I   104                                                      
REMARK 465     LEU I  1249                                                      
REMARK 465     GLU I  1250                                                      
REMARK 465     HIS I  1251                                                      
REMARK 465     HIS I  1252                                                      
REMARK 465     HIS I  1253                                                      
REMARK 465     HIS I  1254                                                      
REMARK 465     HIS I  1255                                                      
REMARK 465     HIS I  1256                                                      
REMARK 465     HIS I  1257                                                      
REMARK 465     HIS I  1258                                                      
REMARK 465     HIS I  1259                                                      
REMARK 465     HIS I  1260                                                      
REMARK 465     MET J     0                                                      
REMARK 465     MET K     1                                                      
REMARK 465     ASP K     2                                                      
REMARK 465     ALA K     3                                                      
REMARK 465     LYS K     4                                                      
REMARK 465     ALA K     5                                                      
REMARK 465     ARG K     6                                                      
REMARK 465     ASN K     7                                                      
REMARK 465     CYS K     8                                                      
REMARK 465     LEU K     9                                                      
REMARK 465     LEU K    10                                                      
REMARK 465     GLN K    11                                                      
REMARK 465     HIS K    12                                                      
REMARK 465     ARG K    13                                                      
REMARK 465     GLU K    14                                                      
REMARK 465     ALA K    15                                                      
REMARK 465     LEU K    16                                                      
REMARK 465     GLU K    17                                                      
REMARK 465     LYS K    18                                                      
REMARK 465     ASP K    19                                                      
REMARK 465     ILE K    20                                                      
REMARK 465     LYS K    21                                                      
REMARK 465     THR K    22                                                      
REMARK 465     SER K    23                                                      
REMARK 465     TYR K    24                                                      
REMARK 465     ILE K    25                                                      
REMARK 465     MET K    26                                                      
REMARK 465     ASP K    27                                                      
REMARK 465     HIS K    28                                                      
REMARK 465     MET K    29                                                      
REMARK 465     ILE K    30                                                      
REMARK 465     SER K    31                                                      
REMARK 465     ASP K    32                                                      
REMARK 465     GLY K    33                                                      
REMARK 465     PHE K    34                                                      
REMARK 465     LEU K    35                                                      
REMARK 465     THR K    36                                                      
REMARK 465     ILE K    37                                                      
REMARK 465     SER K    38                                                      
REMARK 465     GLU K    39                                                      
REMARK 465     GLU K    40                                                      
REMARK 465     GLU K    41                                                      
REMARK 465     LYS K    42                                                      
REMARK 465     VAL K    43                                                      
REMARK 465     ARG K    44                                                      
REMARK 465     ASN K    45                                                      
REMARK 465     GLU K    46                                                      
REMARK 465     PRO K    47                                                      
REMARK 465     THR K    48                                                      
REMARK 465     GLN K    49                                                      
REMARK 465     GLN K    50                                                      
REMARK 465     GLN K    51                                                      
REMARK 465     ARG K    52                                                      
REMARK 465     ALA K    53                                                      
REMARK 465     ALA K    54                                                      
REMARK 465     MET K    55                                                      
REMARK 465     LEU K    56                                                      
REMARK 465     ILE K    57                                                      
REMARK 465     LYS K    58                                                      
REMARK 465     MET K    59                                                      
REMARK 465     ILE K    60                                                      
REMARK 465     LEU K    61                                                      
REMARK 465     LYS K    62                                                      
REMARK 465     LYS K    63                                                      
REMARK 465     ASP K    64                                                      
REMARK 465     ASN K    65                                                      
REMARK 465     ASP K    66                                                      
REMARK 465     SER K    67                                                      
REMARK 465     TYR K    68                                                      
REMARK 465     VAL K    69                                                      
REMARK 465     SER K    70                                                      
REMARK 465     PHE K    71                                                      
REMARK 465     TYR K    72                                                      
REMARK 465     ASN K    73                                                      
REMARK 465     ALA K    74                                                      
REMARK 465     LEU K    75                                                      
REMARK 465     LEU K    76                                                      
REMARK 465     HIS K    77                                                      
REMARK 465     GLU K    78                                                      
REMARK 465     GLY K    79                                                      
REMARK 465     TYR K    80                                                      
REMARK 465     LYS K    81                                                      
REMARK 465     ASP K    82                                                      
REMARK 465     LEU K    83                                                      
REMARK 465     ALA K    84                                                      
REMARK 465     ALA K    85                                                      
REMARK 465     LEU K    86                                                      
REMARK 465     LEU K    87                                                      
REMARK 465     HIS K    88                                                      
REMARK 465     ASP K    89                                                      
REMARK 465     GLY K    90                                                      
REMARK 465     ILE K    91                                                      
REMARK 465     PRO K    92                                                      
REMARK 465     VAL K    93                                                      
REMARK 465     VAL K    94                                                      
REMARK 465     SER K    95                                                      
REMARK 465     SER K    96                                                      
REMARK 465     SER K    97                                                      
REMARK 465     SER K    98                                                      
REMARK 465     GLY K    99                                                      
REMARK 465     LYS K   100                                                      
REMARK 465     ASP K   101                                                      
REMARK 465     SER K   102                                                      
REMARK 465     VAL K   103                                                      
REMARK 465     SER K   104                                                      
REMARK 465     LEU K  1249                                                      
REMARK 465     GLU K  1250                                                      
REMARK 465     HIS K  1251                                                      
REMARK 465     HIS K  1252                                                      
REMARK 465     HIS K  1253                                                      
REMARK 465     HIS K  1254                                                      
REMARK 465     HIS K  1255                                                      
REMARK 465     HIS K  1256                                                      
REMARK 465     HIS K  1257                                                      
REMARK 465     HIS K  1258                                                      
REMARK 465     HIS K  1259                                                      
REMARK 465     HIS K  1260                                                      
REMARK 465     MET L     0                                                      
REMARK 465     MET M     1                                                      
REMARK 465     ASP M     2                                                      
REMARK 465     ALA M     3                                                      
REMARK 465     LYS M     4                                                      
REMARK 465     ALA M     5                                                      
REMARK 465     ARG M     6                                                      
REMARK 465     ASN M     7                                                      
REMARK 465     CYS M     8                                                      
REMARK 465     LEU M     9                                                      
REMARK 465     LEU M    10                                                      
REMARK 465     GLN M    11                                                      
REMARK 465     HIS M    12                                                      
REMARK 465     ARG M    13                                                      
REMARK 465     GLU M    14                                                      
REMARK 465     ALA M    15                                                      
REMARK 465     LEU M    16                                                      
REMARK 465     GLU M    17                                                      
REMARK 465     LYS M    18                                                      
REMARK 465     ASP M    19                                                      
REMARK 465     ILE M    20                                                      
REMARK 465     LYS M    21                                                      
REMARK 465     THR M    22                                                      
REMARK 465     SER M    23                                                      
REMARK 465     TYR M    24                                                      
REMARK 465     ILE M    25                                                      
REMARK 465     MET M    26                                                      
REMARK 465     ASP M    27                                                      
REMARK 465     HIS M    28                                                      
REMARK 465     MET M    29                                                      
REMARK 465     ILE M    30                                                      
REMARK 465     SER M    31                                                      
REMARK 465     ASP M    32                                                      
REMARK 465     GLY M    33                                                      
REMARK 465     PHE M    34                                                      
REMARK 465     LEU M    35                                                      
REMARK 465     THR M    36                                                      
REMARK 465     ILE M    37                                                      
REMARK 465     SER M    38                                                      
REMARK 465     GLU M    39                                                      
REMARK 465     GLU M    40                                                      
REMARK 465     GLU M    41                                                      
REMARK 465     LYS M    42                                                      
REMARK 465     VAL M    43                                                      
REMARK 465     ARG M    44                                                      
REMARK 465     ASN M    45                                                      
REMARK 465     GLU M    46                                                      
REMARK 465     PRO M    47                                                      
REMARK 465     THR M    48                                                      
REMARK 465     GLN M    49                                                      
REMARK 465     GLN M    50                                                      
REMARK 465     GLN M    51                                                      
REMARK 465     ARG M    52                                                      
REMARK 465     ALA M    53                                                      
REMARK 465     ALA M    54                                                      
REMARK 465     MET M    55                                                      
REMARK 465     LEU M    56                                                      
REMARK 465     ILE M    57                                                      
REMARK 465     LYS M    58                                                      
REMARK 465     MET M    59                                                      
REMARK 465     ILE M    60                                                      
REMARK 465     LEU M    61                                                      
REMARK 465     LYS M    62                                                      
REMARK 465     LYS M    63                                                      
REMARK 465     ASP M    64                                                      
REMARK 465     ASN M    65                                                      
REMARK 465     ASP M    66                                                      
REMARK 465     SER M    67                                                      
REMARK 465     TYR M    68                                                      
REMARK 465     VAL M    69                                                      
REMARK 465     SER M    70                                                      
REMARK 465     PHE M    71                                                      
REMARK 465     TYR M    72                                                      
REMARK 465     ASN M    73                                                      
REMARK 465     ALA M    74                                                      
REMARK 465     LEU M    75                                                      
REMARK 465     LEU M    76                                                      
REMARK 465     HIS M    77                                                      
REMARK 465     GLU M    78                                                      
REMARK 465     GLY M    79                                                      
REMARK 465     TYR M    80                                                      
REMARK 465     LYS M    81                                                      
REMARK 465     ASP M    82                                                      
REMARK 465     LEU M    83                                                      
REMARK 465     ALA M    84                                                      
REMARK 465     ALA M    85                                                      
REMARK 465     LEU M    86                                                      
REMARK 465     LEU M    87                                                      
REMARK 465     HIS M    88                                                      
REMARK 465     ASP M    89                                                      
REMARK 465     GLY M    90                                                      
REMARK 465     ILE M    91                                                      
REMARK 465     PRO M    92                                                      
REMARK 465     VAL M    93                                                      
REMARK 465     VAL M    94                                                      
REMARK 465     SER M    95                                                      
REMARK 465     SER M    96                                                      
REMARK 465     SER M    97                                                      
REMARK 465     SER M    98                                                      
REMARK 465     GLY M    99                                                      
REMARK 465     LYS M   100                                                      
REMARK 465     ASP M   101                                                      
REMARK 465     SER M   102                                                      
REMARK 465     VAL M   103                                                      
REMARK 465     SER M   104                                                      
REMARK 465     LEU M  1249                                                      
REMARK 465     GLU M  1250                                                      
REMARK 465     HIS M  1251                                                      
REMARK 465     HIS M  1252                                                      
REMARK 465     HIS M  1253                                                      
REMARK 465     HIS M  1254                                                      
REMARK 465     HIS M  1255                                                      
REMARK 465     HIS M  1256                                                      
REMARK 465     HIS M  1257                                                      
REMARK 465     HIS M  1258                                                      
REMARK 465     HIS M  1259                                                      
REMARK 465     HIS M  1260                                                      
REMARK 465     MET N     0                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    GLN C   558     N    PHE C   560              2.06            
REMARK 500   O    GLN A   558     N    PHE A   560              2.06            
REMARK 500   O    GLN G   558     N    PHE G   560              2.06            
REMARK 500   O    GLN E   558     N    PHE E   560              2.06            
REMARK 500   O    GLN I   558     N    PHE I   560              2.06            
REMARK 500   O    GLN K   558     N    PHE K   560              2.06            
REMARK 500   O    GLN M   558     N    PHE M   560              2.06            
REMARK 500   O    PRO M   559     N    PRO M   561              2.08            
REMARK 500   O    PRO K   559     N    PRO K   561              2.08            
REMARK 500   O    PRO I   559     N    PRO I   561              2.08            
REMARK 500   O    PRO G   559     N    PRO G   561              2.08            
REMARK 500   O    PRO E   559     N    PRO E   561              2.08            
REMARK 500   O    PRO C   559     N    PRO C   561              2.08            
REMARK 500   O    PRO A   559     N    PRO A   561              2.08            
REMARK 500   SG   CYS J    14     CAB  HEM J   201              2.09            
REMARK 500   SG   CYS L    14     CAB  HEM L   201              2.09            
REMARK 500   SG   CYS N    14     CAB  HEM N   201              2.09            
REMARK 500   SG   CYS H    14     CAB  HEM H   201              2.09            
REMARK 500   SG   CYS F    14     CAB  HEM F   201              2.09            
REMARK 500   SG   CYS B    14     CAB  HEM B   201              2.09            
REMARK 500   SG   CYS D    14     CAB  HEM D   201              2.09            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    PRO A 147   C   -  N   -  CD  ANGL. DEV. = -14.1 DEGREES          
REMARK 500    PRO A 281   C   -  N   -  CD  ANGL. DEV. = -17.4 DEGREES          
REMARK 500    PRO A 561   C   -  N   -  CD  ANGL. DEV. = -19.1 DEGREES          
REMARK 500    PRO C 147   C   -  N   -  CD  ANGL. DEV. = -14.1 DEGREES          
REMARK 500    PRO C 281   C   -  N   -  CD  ANGL. DEV. = -17.4 DEGREES          
REMARK 500    PRO C 561   C   -  N   -  CD  ANGL. DEV. = -19.1 DEGREES          
REMARK 500    PRO E 147   C   -  N   -  CD  ANGL. DEV. = -14.0 DEGREES          
REMARK 500    PRO E 281   C   -  N   -  CD  ANGL. DEV. = -17.3 DEGREES          
REMARK 500    PRO E 561   C   -  N   -  CD  ANGL. DEV. = -19.1 DEGREES          
REMARK 500    PRO G 147   C   -  N   -  CD  ANGL. DEV. = -14.1 DEGREES          
REMARK 500    PRO G 281   C   -  N   -  CD  ANGL. DEV. = -17.3 DEGREES          
REMARK 500    PRO G 561   C   -  N   -  CD  ANGL. DEV. = -19.1 DEGREES          
REMARK 500    PRO I 147   C   -  N   -  CD  ANGL. DEV. = -14.1 DEGREES          
REMARK 500    PRO I 281   C   -  N   -  CD  ANGL. DEV. = -17.3 DEGREES          
REMARK 500    PRO I 561   C   -  N   -  CD  ANGL. DEV. = -19.1 DEGREES          
REMARK 500    PRO K 147   C   -  N   -  CD  ANGL. DEV. = -14.1 DEGREES          
REMARK 500    PRO K 281   C   -  N   -  CD  ANGL. DEV. = -17.3 DEGREES          
REMARK 500    PRO K 561   C   -  N   -  CD  ANGL. DEV. = -19.1 DEGREES          
REMARK 500    PRO M 147   C   -  N   -  CD  ANGL. DEV. = -14.1 DEGREES          
REMARK 500    PRO M 281   C   -  N   -  CD  ANGL. DEV. = -17.2 DEGREES          
REMARK 500    PRO M 561   C   -  N   -  CD  ANGL. DEV. = -19.1 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    THR A 128      151.44    -40.62                                   
REMARK 500    GLU A 146      141.52     66.56                                   
REMARK 500    PRO A 147      179.49    -33.36                                   
REMARK 500    GLU A 210        7.43     82.30                                   
REMARK 500    ASP A 244     -127.33     60.92                                   
REMARK 500    VAL A 245      120.62     98.80                                   
REMARK 500    SER A 285      -69.50   -137.51                                   
REMARK 500    LEU A 286     -178.15     79.98                                   
REMARK 500    LYS A 348        4.17     87.05                                   
REMARK 500    LEU A 424      106.45   -171.62                                   
REMARK 500    TYR A 467     -127.09   -113.37                                   
REMARK 500    LYS A 495        6.10     81.33                                   
REMARK 500    LEU A 503      -72.36   -103.46                                   
REMARK 500    LEU A 533     -111.91    -97.12                                   
REMARK 500    ARG A 557      -97.13    -16.95                                   
REMARK 500    GLN A 558      -71.25   -161.94                                   
REMARK 500    PRO A 559       60.14    -48.97                                   
REMARK 500    PHE A 560       65.29    -42.69                                   
REMARK 500    PRO A 561      132.18    -24.58                                   
REMARK 500    ASN A 562       87.54    -46.46                                   
REMARK 500    LEU A 568       61.99    -63.67                                   
REMARK 500    GLU A 572      -94.66     72.88                                   
REMARK 500    THR A 573      -62.72    169.79                                   
REMARK 500    SER A 574     -151.83     45.12                                   
REMARK 500    MET A 592       -8.22     89.66                                   
REMARK 500    THR A 604      110.35     76.10                                   
REMARK 500    CYS A 633     -154.09    -99.04                                   
REMARK 500    LYS A 637       -1.70     97.21                                   
REMARK 500    GLU A 645      -93.53    -41.96                                   
REMARK 500    ASP A 658      165.76     69.81                                   
REMARK 500    LYS A 679       26.39     92.03                                   
REMARK 500    MET A 687      -68.07   -109.08                                   
REMARK 500    VAL A 692      -72.00   -122.28                                   
REMARK 500    GLU A 697      -27.24   -165.09                                   
REMARK 500    HIS A 712      -76.77    -79.97                                   
REMARK 500    CYS A 723      -28.24     81.12                                   
REMARK 500    ASN A 737      113.83   -168.17                                   
REMARK 500    ARG A 778      -55.43   -124.61                                   
REMARK 500    SER A 780       92.67   -164.80                                   
REMARK 500    LEU A 788      102.59   -163.86                                   
REMARK 500    GLU A 795     -128.99    -72.32                                   
REMARK 500    LYS A 802      -84.19   -109.08                                   
REMARK 500    CYS A 804       69.34   -105.16                                   
REMARK 500    LYS A 818     -102.89     52.93                                   
REMARK 500    LEU A 832      -78.22   -129.36                                   
REMARK 500    GLU A 834       91.63   -167.90                                   
REMARK 500    HIS A 839     -138.42     49.65                                   
REMARK 500    SER A 841     -122.70   -174.31                                   
REMARK 500    ASP A 847      107.90   -160.86                                   
REMARK 500    ASN A 852       12.47     53.07                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     707 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG K1302  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 DTP K1301   O2B                                                    
REMARK 620 2 SER K 161   OG   74.8                                              
REMARK 620 3 DTP K1301   O3G  69.7 136.2                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG I1302  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 DTP I1301   O2B                                                    
REMARK 620 2 SER I 161   OG   74.8                                              
REMARK 620 3 DTP I1301   O3G  69.7 136.2                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG G1302  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 DTP G1301   O2B                                                    
REMARK 620 2 SER G 161   OG   74.8                                              
REMARK 620 3 DTP G1301   O3G  69.7 136.2                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG C1302  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 DTP C1301   O2B                                                    
REMARK 620 2 SER C 161   OG   74.8                                              
REMARK 620 3 DTP C1301   O3G  69.7 136.2                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG M1302  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 DTP M1301   O2B                                                    
REMARK 620 2 SER M 161   OG   74.8                                              
REMARK 620 3 DTP M1301   O3G  69.7 136.2                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG A1302  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 DTP A1301   O2B                                                    
REMARK 620 2 SER A 161   OG   74.8                                              
REMARK 620 3 DTP A1301   O3G  69.7 136.2                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG E1302  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 DTP E1301   O2B                                                    
REMARK 620 2 SER E 161   OG   74.8                                              
REMARK 620 3 DTP E1301   O3G  69.7 136.2                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             HEM J 201  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS J  18   NE2                                                    
REMARK 620 2 HEM J 201   NA  107.7                                              
REMARK 620 3 HEM J 201   NB  112.2  87.9                                        
REMARK 620 4 HEM J 201   NC   73.1 173.7  86.0                                  
REMARK 620 5 HEM J 201   ND   68.1  93.7 178.1  92.4                            
REMARK 620 6 MET J  80   SD  149.1  88.4  94.1  93.8  85.0                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             HEM B 201  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS B  18   NE2                                                    
REMARK 620 2 HEM B 201   NA  107.7                                              
REMARK 620 3 HEM B 201   NB  112.2  88.0                                        
REMARK 620 4 HEM B 201   NC   73.1 173.7  86.0                                  
REMARK 620 5 HEM B 201   ND   68.1  93.8 178.0  92.4                            
REMARK 620 6 MET B  80   SD  149.1  88.5  94.1  93.8  85.0                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             HEM H 201  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS H  18   NE2                                                    
REMARK 620 2 HEM H 201   NA  107.7                                              
REMARK 620 3 HEM H 201   NB  112.2  87.9                                        
REMARK 620 4 HEM H 201   NC   73.1 173.7  86.0                                  
REMARK 620 5 HEM H 201   ND   68.1  93.7 178.1  92.4                            
REMARK 620 6 MET H  80   SD  149.1  88.5  94.1  93.8  85.0                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             HEM D 201  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS D  18   NE2                                                    
REMARK 620 2 HEM D 201   NA  107.7                                              
REMARK 620 3 HEM D 201   NB  112.2  88.0                                        
REMARK 620 4 HEM D 201   NC   73.1 173.7  86.0                                  
REMARK 620 5 HEM D 201   ND   68.1  93.8 178.0  92.3                            
REMARK 620 6 MET D  80   SD  149.0  88.5  94.1  93.8  85.0                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             HEM L 201  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS L  18   NE2                                                    
REMARK 620 2 HEM L 201   NA  107.7                                              
REMARK 620 3 HEM L 201   NB  112.2  87.9                                        
REMARK 620 4 HEM L 201   NC   73.1 173.7  86.0                                  
REMARK 620 5 HEM L 201   ND   68.1  93.8 178.1  92.3                            
REMARK 620 6 MET L  80   SD  149.1  88.4  94.1  93.8  85.0                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             HEM N 201  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS N  18   NE2                                                    
REMARK 620 2 HEM N 201   NA  107.7                                              
REMARK 620 3 HEM N 201   NB  112.2  87.9                                        
REMARK 620 4 HEM N 201   NC   73.1 173.7  86.0                                  
REMARK 620 5 HEM N 201   ND   68.1  93.8 178.0  92.3                            
REMARK 620 6 MET N  80   SD  149.1  88.4  94.1  93.8  85.0                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             HEM F 201  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS F  18   NE2                                                    
REMARK 620 2 HEM F 201   NA  107.7                                              
REMARK 620 3 HEM F 201   NB  112.2  88.0                                        
REMARK 620 4 HEM F 201   NC   73.1 173.7  86.0                                  
REMARK 620 5 HEM F 201   ND   68.1  93.8 178.1  92.3                            
REMARK 620 6 MET F  80   SD  149.0  88.5  94.1  93.8  85.0                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DTP A 1301                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG A 1302                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE HEM B 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DTP C 1301                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG C 1302                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE HEM D 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DTP E 1301                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG E 1302                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE HEM F 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DTP G 1301                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG G 1302                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE HEM H 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DTP I 1301                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG I 1302                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE HEM J 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DTP K 1301                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG K 1302                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE HEM L 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE DTP M 1301                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE MG M 1302                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE HEM N 201                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-6480   RELATED DB: EMDB                              
DBREF  3JBT A    1  1248  UNP    O14727   APAF_HUMAN       1   1248             
DBREF  3JBT B    0   104  UNP    P00004   CYC_HORSE        1    105             
DBREF  3JBT C    1  1248  UNP    O14727   APAF_HUMAN       1   1248             
DBREF  3JBT D    0   104  UNP    P00004   CYC_HORSE        1    105             
DBREF  3JBT E    1  1248  UNP    O14727   APAF_HUMAN       1   1248             
DBREF  3JBT F    0   104  UNP    P00004   CYC_HORSE        1    105             
DBREF  3JBT G    1  1248  UNP    O14727   APAF_HUMAN       1   1248             
DBREF  3JBT H    0   104  UNP    P00004   CYC_HORSE        1    105             
DBREF  3JBT I    1  1248  UNP    O14727   APAF_HUMAN       1   1248             
DBREF  3JBT J    0   104  UNP    P00004   CYC_HORSE        1    105             
DBREF  3JBT K    1  1248  UNP    O14727   APAF_HUMAN       1   1248             
DBREF  3JBT L    0   104  UNP    P00004   CYC_HORSE        1    105             
DBREF  3JBT M    1  1248  UNP    O14727   APAF_HUMAN       1   1248             
DBREF  3JBT N    0   104  UNP    P00004   CYC_HORSE        1    105             
SEQADV 3JBT LEU A 1249  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT GLU A 1250  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS A 1251  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS A 1252  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS A 1253  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS A 1254  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS A 1255  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS A 1256  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS A 1257  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS A 1258  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS A 1259  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS A 1260  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT LEU C 1249  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT GLU C 1250  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS C 1251  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS C 1252  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS C 1253  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS C 1254  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS C 1255  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS C 1256  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS C 1257  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS C 1258  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS C 1259  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS C 1260  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT LEU E 1249  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT GLU E 1250  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS E 1251  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS E 1252  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS E 1253  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS E 1254  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS E 1255  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS E 1256  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS E 1257  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS E 1258  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS E 1259  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS E 1260  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT LEU G 1249  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT GLU G 1250  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS G 1251  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS G 1252  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS G 1253  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS G 1254  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS G 1255  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS G 1256  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS G 1257  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS G 1258  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS G 1259  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS G 1260  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT LEU I 1249  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT GLU I 1250  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS I 1251  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS I 1252  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS I 1253  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS I 1254  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS I 1255  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS I 1256  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS I 1257  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS I 1258  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS I 1259  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS I 1260  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT LEU K 1249  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT GLU K 1250  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS K 1251  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS K 1252  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS K 1253  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS K 1254  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS K 1255  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS K 1256  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS K 1257  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS K 1258  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS K 1259  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS K 1260  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT LEU M 1249  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT GLU M 1250  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS M 1251  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS M 1252  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS M 1253  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS M 1254  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS M 1255  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS M 1256  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS M 1257  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS M 1258  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS M 1259  UNP  O14727              EXPRESSION TAG                 
SEQADV 3JBT HIS M 1260  UNP  O14727              EXPRESSION TAG                 
SEQRES   1 A 1260  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 A 1260  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 A 1260  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 A 1260  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 A 1260  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 A 1260  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 A 1260  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 A 1260  PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER          
SEQRES   9 A 1260  GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY          
SEQRES  10 A 1260  GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS          
SEQRES  11 A 1260  LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU          
SEQRES  12 A 1260  LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA          
SEQRES  13 A 1260  GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG          
SEQRES  14 A 1260  ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL          
SEQRES  15 A 1260  HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU          
SEQRES  16 A 1260  LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN          
SEQRES  17 A 1260  ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU          
SEQRES  18 A 1260  GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS          
SEQRES  19 A 1260  HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP          
SEQRES  20 A 1260  SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE          
SEQRES  21 A 1260  LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL          
SEQRES  22 A 1260  MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU          
SEQRES  23 A 1260  GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL          
SEQRES  24 A 1260  ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER          
SEQRES  25 A 1260  ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER          
SEQRES  26 A 1260  LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP          
SEQRES  27 A 1260  GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS          
SEQRES  28 A 1260  ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU          
SEQRES  29 A 1260  ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU          
SEQRES  30 A 1260  ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN          
SEQRES  31 A 1260  LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU          
SEQRES  32 A 1260  TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN          
SEQRES  33 A 1260  GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN          
SEQRES  34 A 1260  GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL          
SEQRES  35 A 1260  ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP          
SEQRES  36 A 1260  LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS          
SEQRES  37 A 1260  GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET          
SEQRES  38 A 1260  TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA          
SEQRES  39 A 1260  LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU          
SEQRES  40 A 1260  ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA          
SEQRES  41 A 1260  HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU          
SEQRES  42 A 1260  ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU          
SEQRES  43 A 1260  PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO          
SEQRES  44 A 1260  PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU          
SEQRES  45 A 1260  THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS          
SEQRES  46 A 1260  GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE          
SEQRES  47 A 1260  ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL          
SEQRES  48 A 1260  ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER          
SEQRES  49 A 1260  GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS          
SEQRES  50 A 1260  THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU          
SEQRES  51 A 1260  LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS          
SEQRES  52 A 1260  ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER          
SEQRES  53 A 1260  VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY          
SEQRES  54 A 1260  GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL          
SEQRES  55 A 1260  ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU          
SEQRES  56 A 1260  LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP          
SEQRES  57 A 1260  ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY          
SEQRES  58 A 1260  HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP          
SEQRES  59 A 1260  ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU          
SEQRES  60 A 1260  LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER          
SEQRES  61 A 1260  ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO          
SEQRES  62 A 1260  GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP          
SEQRES  63 A 1260  SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN          
SEQRES  64 A 1260  LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU          
SEQRES  65 A 1260  GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR          
SEQRES  66 A 1260  CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA          
SEQRES  67 A 1260  LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER          
SEQRES  68 A 1260  ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP          
SEQRES  69 A 1260  VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE          
SEQRES  70 A 1260  LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU          
SEQRES  71 A 1260  THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS          
SEQRES  72 A 1260  GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET          
SEQRES  73 A 1260  VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE          
SEQRES  74 A 1260  ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA          
SEQRES  75 A 1260  GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR          
SEQRES  76 A 1260  ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU          
SEQRES  77 A 1260  GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN          
SEQRES  78 A 1260  HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP          
SEQRES  79 A 1260  GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE          
SEQRES  80 A 1260  GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU          
SEQRES  81 A 1260  ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU          
SEQRES  82 A 1260  LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR          
SEQRES  83 A 1260  VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS          
SEQRES  84 A 1260  ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP          
SEQRES  85 A 1260  ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA          
SEQRES  86 A 1260  ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU          
SEQRES  87 A 1260  PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG          
SEQRES  88 A 1260  CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR          
SEQRES  89 A 1260  GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER          
SEQRES  90 A 1260  ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU          
SEQRES  91 A 1260  GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU          
SEQRES  92 A 1260  CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY          
SEQRES  93 A 1260  GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER          
SEQRES  94 A 1260  SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS          
SEQRES  95 A 1260  ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL          
SEQRES  96 A 1260  ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU          
SEQRES  97 A 1260  LEU GLU HIS HIS HIS HIS HIS HIS HIS HIS HIS HIS              
SEQRES   1 B  105  MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN          
SEQRES   2 B  105  LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS          
SEQRES   3 B  105  HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG          
SEQRES   4 B  105  LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA          
SEQRES   5 B  105  ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU          
SEQRES   6 B  105  MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY          
SEQRES   7 B  105  THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU          
SEQRES   8 B  105  ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN          
SEQRES   9 B  105  GLU                                                          
SEQRES   1 C 1260  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 C 1260  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 C 1260  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 C 1260  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 C 1260  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 C 1260  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 C 1260  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 C 1260  PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER          
SEQRES   9 C 1260  GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY          
SEQRES  10 C 1260  GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS          
SEQRES  11 C 1260  LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU          
SEQRES  12 C 1260  LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA          
SEQRES  13 C 1260  GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG          
SEQRES  14 C 1260  ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL          
SEQRES  15 C 1260  HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU          
SEQRES  16 C 1260  LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN          
SEQRES  17 C 1260  ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU          
SEQRES  18 C 1260  GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS          
SEQRES  19 C 1260  HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP          
SEQRES  20 C 1260  SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE          
SEQRES  21 C 1260  LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL          
SEQRES  22 C 1260  MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU          
SEQRES  23 C 1260  GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL          
SEQRES  24 C 1260  ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER          
SEQRES  25 C 1260  ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER          
SEQRES  26 C 1260  LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP          
SEQRES  27 C 1260  GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS          
SEQRES  28 C 1260  ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU          
SEQRES  29 C 1260  ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU          
SEQRES  30 C 1260  ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN          
SEQRES  31 C 1260  LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU          
SEQRES  32 C 1260  TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN          
SEQRES  33 C 1260  GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN          
SEQRES  34 C 1260  GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL          
SEQRES  35 C 1260  ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP          
SEQRES  36 C 1260  LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS          
SEQRES  37 C 1260  GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET          
SEQRES  38 C 1260  TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA          
SEQRES  39 C 1260  LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU          
SEQRES  40 C 1260  ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA          
SEQRES  41 C 1260  HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU          
SEQRES  42 C 1260  ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU          
SEQRES  43 C 1260  PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO          
SEQRES  44 C 1260  PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU          
SEQRES  45 C 1260  THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS          
SEQRES  46 C 1260  GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE          
SEQRES  47 C 1260  ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL          
SEQRES  48 C 1260  ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER          
SEQRES  49 C 1260  GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS          
SEQRES  50 C 1260  THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU          
SEQRES  51 C 1260  LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS          
SEQRES  52 C 1260  ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER          
SEQRES  53 C 1260  VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY          
SEQRES  54 C 1260  GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL          
SEQRES  55 C 1260  ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU          
SEQRES  56 C 1260  LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP          
SEQRES  57 C 1260  ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY          
SEQRES  58 C 1260  HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP          
SEQRES  59 C 1260  ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU          
SEQRES  60 C 1260  LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER          
SEQRES  61 C 1260  ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO          
SEQRES  62 C 1260  GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP          
SEQRES  63 C 1260  SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN          
SEQRES  64 C 1260  LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU          
SEQRES  65 C 1260  GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR          
SEQRES  66 C 1260  CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA          
SEQRES  67 C 1260  LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER          
SEQRES  68 C 1260  ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP          
SEQRES  69 C 1260  VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE          
SEQRES  70 C 1260  LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU          
SEQRES  71 C 1260  THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS          
SEQRES  72 C 1260  GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET          
SEQRES  73 C 1260  VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE          
SEQRES  74 C 1260  ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA          
SEQRES  75 C 1260  GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR          
SEQRES  76 C 1260  ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU          
SEQRES  77 C 1260  GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN          
SEQRES  78 C 1260  HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP          
SEQRES  79 C 1260  GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE          
SEQRES  80 C 1260  GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU          
SEQRES  81 C 1260  ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU          
SEQRES  82 C 1260  LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR          
SEQRES  83 C 1260  VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS          
SEQRES  84 C 1260  ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP          
SEQRES  85 C 1260  ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA          
SEQRES  86 C 1260  ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU          
SEQRES  87 C 1260  PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG          
SEQRES  88 C 1260  CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR          
SEQRES  89 C 1260  GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER          
SEQRES  90 C 1260  ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU          
SEQRES  91 C 1260  GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU          
SEQRES  92 C 1260  CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY          
SEQRES  93 C 1260  GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER          
SEQRES  94 C 1260  SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS          
SEQRES  95 C 1260  ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL          
SEQRES  96 C 1260  ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU          
SEQRES  97 C 1260  LEU GLU HIS HIS HIS HIS HIS HIS HIS HIS HIS HIS              
SEQRES   1 D  105  MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN          
SEQRES   2 D  105  LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS          
SEQRES   3 D  105  HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG          
SEQRES   4 D  105  LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA          
SEQRES   5 D  105  ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU          
SEQRES   6 D  105  MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY          
SEQRES   7 D  105  THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU          
SEQRES   8 D  105  ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN          
SEQRES   9 D  105  GLU                                                          
SEQRES   1 E 1260  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 E 1260  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 E 1260  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 E 1260  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 E 1260  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 E 1260  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 E 1260  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 E 1260  PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER          
SEQRES   9 E 1260  GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY          
SEQRES  10 E 1260  GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS          
SEQRES  11 E 1260  LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU          
SEQRES  12 E 1260  LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA          
SEQRES  13 E 1260  GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG          
SEQRES  14 E 1260  ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL          
SEQRES  15 E 1260  HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU          
SEQRES  16 E 1260  LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN          
SEQRES  17 E 1260  ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU          
SEQRES  18 E 1260  GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS          
SEQRES  19 E 1260  HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP          
SEQRES  20 E 1260  SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE          
SEQRES  21 E 1260  LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL          
SEQRES  22 E 1260  MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU          
SEQRES  23 E 1260  GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL          
SEQRES  24 E 1260  ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER          
SEQRES  25 E 1260  ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER          
SEQRES  26 E 1260  LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP          
SEQRES  27 E 1260  GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS          
SEQRES  28 E 1260  ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU          
SEQRES  29 E 1260  ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU          
SEQRES  30 E 1260  ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN          
SEQRES  31 E 1260  LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU          
SEQRES  32 E 1260  TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN          
SEQRES  33 E 1260  GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN          
SEQRES  34 E 1260  GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL          
SEQRES  35 E 1260  ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP          
SEQRES  36 E 1260  LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS          
SEQRES  37 E 1260  GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET          
SEQRES  38 E 1260  TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA          
SEQRES  39 E 1260  LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU          
SEQRES  40 E 1260  ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA          
SEQRES  41 E 1260  HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU          
SEQRES  42 E 1260  ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU          
SEQRES  43 E 1260  PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO          
SEQRES  44 E 1260  PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU          
SEQRES  45 E 1260  THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS          
SEQRES  46 E 1260  GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE          
SEQRES  47 E 1260  ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL          
SEQRES  48 E 1260  ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER          
SEQRES  49 E 1260  GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS          
SEQRES  50 E 1260  THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU          
SEQRES  51 E 1260  LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS          
SEQRES  52 E 1260  ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER          
SEQRES  53 E 1260  VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY          
SEQRES  54 E 1260  GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL          
SEQRES  55 E 1260  ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU          
SEQRES  56 E 1260  LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP          
SEQRES  57 E 1260  ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY          
SEQRES  58 E 1260  HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP          
SEQRES  59 E 1260  ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU          
SEQRES  60 E 1260  LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER          
SEQRES  61 E 1260  ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO          
SEQRES  62 E 1260  GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP          
SEQRES  63 E 1260  SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN          
SEQRES  64 E 1260  LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU          
SEQRES  65 E 1260  GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR          
SEQRES  66 E 1260  CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA          
SEQRES  67 E 1260  LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER          
SEQRES  68 E 1260  ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP          
SEQRES  69 E 1260  VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE          
SEQRES  70 E 1260  LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU          
SEQRES  71 E 1260  THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS          
SEQRES  72 E 1260  GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET          
SEQRES  73 E 1260  VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE          
SEQRES  74 E 1260  ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA          
SEQRES  75 E 1260  GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR          
SEQRES  76 E 1260  ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU          
SEQRES  77 E 1260  GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN          
SEQRES  78 E 1260  HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP          
SEQRES  79 E 1260  GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE          
SEQRES  80 E 1260  GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU          
SEQRES  81 E 1260  ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU          
SEQRES  82 E 1260  LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR          
SEQRES  83 E 1260  VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS          
SEQRES  84 E 1260  ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP          
SEQRES  85 E 1260  ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA          
SEQRES  86 E 1260  ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU          
SEQRES  87 E 1260  PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG          
SEQRES  88 E 1260  CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR          
SEQRES  89 E 1260  GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER          
SEQRES  90 E 1260  ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU          
SEQRES  91 E 1260  GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU          
SEQRES  92 E 1260  CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY          
SEQRES  93 E 1260  GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER          
SEQRES  94 E 1260  SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS          
SEQRES  95 E 1260  ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL          
SEQRES  96 E 1260  ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU          
SEQRES  97 E 1260  LEU GLU HIS HIS HIS HIS HIS HIS HIS HIS HIS HIS              
SEQRES   1 F  105  MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN          
SEQRES   2 F  105  LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS          
SEQRES   3 F  105  HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG          
SEQRES   4 F  105  LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA          
SEQRES   5 F  105  ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU          
SEQRES   6 F  105  MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY          
SEQRES   7 F  105  THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU          
SEQRES   8 F  105  ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN          
SEQRES   9 F  105  GLU                                                          
SEQRES   1 G 1260  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 G 1260  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 G 1260  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 G 1260  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 G 1260  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 G 1260  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 G 1260  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 G 1260  PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER          
SEQRES   9 G 1260  GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY          
SEQRES  10 G 1260  GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS          
SEQRES  11 G 1260  LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU          
SEQRES  12 G 1260  LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA          
SEQRES  13 G 1260  GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG          
SEQRES  14 G 1260  ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL          
SEQRES  15 G 1260  HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU          
SEQRES  16 G 1260  LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN          
SEQRES  17 G 1260  ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU          
SEQRES  18 G 1260  GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS          
SEQRES  19 G 1260  HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP          
SEQRES  20 G 1260  SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE          
SEQRES  21 G 1260  LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL          
SEQRES  22 G 1260  MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU          
SEQRES  23 G 1260  GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL          
SEQRES  24 G 1260  ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER          
SEQRES  25 G 1260  ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER          
SEQRES  26 G 1260  LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP          
SEQRES  27 G 1260  GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS          
SEQRES  28 G 1260  ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU          
SEQRES  29 G 1260  ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU          
SEQRES  30 G 1260  ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN          
SEQRES  31 G 1260  LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU          
SEQRES  32 G 1260  TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN          
SEQRES  33 G 1260  GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN          
SEQRES  34 G 1260  GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL          
SEQRES  35 G 1260  ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP          
SEQRES  36 G 1260  LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS          
SEQRES  37 G 1260  GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET          
SEQRES  38 G 1260  TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA          
SEQRES  39 G 1260  LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU          
SEQRES  40 G 1260  ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA          
SEQRES  41 G 1260  HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU          
SEQRES  42 G 1260  ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU          
SEQRES  43 G 1260  PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO          
SEQRES  44 G 1260  PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU          
SEQRES  45 G 1260  THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS          
SEQRES  46 G 1260  GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE          
SEQRES  47 G 1260  ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL          
SEQRES  48 G 1260  ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER          
SEQRES  49 G 1260  GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS          
SEQRES  50 G 1260  THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU          
SEQRES  51 G 1260  LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS          
SEQRES  52 G 1260  ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER          
SEQRES  53 G 1260  VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY          
SEQRES  54 G 1260  GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL          
SEQRES  55 G 1260  ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU          
SEQRES  56 G 1260  LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP          
SEQRES  57 G 1260  ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY          
SEQRES  58 G 1260  HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP          
SEQRES  59 G 1260  ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU          
SEQRES  60 G 1260  LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER          
SEQRES  61 G 1260  ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO          
SEQRES  62 G 1260  GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP          
SEQRES  63 G 1260  SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN          
SEQRES  64 G 1260  LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU          
SEQRES  65 G 1260  GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR          
SEQRES  66 G 1260  CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA          
SEQRES  67 G 1260  LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER          
SEQRES  68 G 1260  ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP          
SEQRES  69 G 1260  VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE          
SEQRES  70 G 1260  LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU          
SEQRES  71 G 1260  THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS          
SEQRES  72 G 1260  GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET          
SEQRES  73 G 1260  VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE          
SEQRES  74 G 1260  ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA          
SEQRES  75 G 1260  GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR          
SEQRES  76 G 1260  ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU          
SEQRES  77 G 1260  GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN          
SEQRES  78 G 1260  HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP          
SEQRES  79 G 1260  GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE          
SEQRES  80 G 1260  GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU          
SEQRES  81 G 1260  ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU          
SEQRES  82 G 1260  LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR          
SEQRES  83 G 1260  VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS          
SEQRES  84 G 1260  ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP          
SEQRES  85 G 1260  ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA          
SEQRES  86 G 1260  ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU          
SEQRES  87 G 1260  PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG          
SEQRES  88 G 1260  CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR          
SEQRES  89 G 1260  GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER          
SEQRES  90 G 1260  ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU          
SEQRES  91 G 1260  GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU          
SEQRES  92 G 1260  CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY          
SEQRES  93 G 1260  GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER          
SEQRES  94 G 1260  SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS          
SEQRES  95 G 1260  ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL          
SEQRES  96 G 1260  ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU          
SEQRES  97 G 1260  LEU GLU HIS HIS HIS HIS HIS HIS HIS HIS HIS HIS              
SEQRES   1 H  105  MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN          
SEQRES   2 H  105  LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS          
SEQRES   3 H  105  HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG          
SEQRES   4 H  105  LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA          
SEQRES   5 H  105  ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU          
SEQRES   6 H  105  MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY          
SEQRES   7 H  105  THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU          
SEQRES   8 H  105  ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN          
SEQRES   9 H  105  GLU                                                          
SEQRES   1 I 1260  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 I 1260  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 I 1260  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 I 1260  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 I 1260  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 I 1260  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 I 1260  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 I 1260  PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER          
SEQRES   9 I 1260  GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY          
SEQRES  10 I 1260  GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS          
SEQRES  11 I 1260  LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU          
SEQRES  12 I 1260  LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA          
SEQRES  13 I 1260  GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG          
SEQRES  14 I 1260  ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL          
SEQRES  15 I 1260  HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU          
SEQRES  16 I 1260  LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN          
SEQRES  17 I 1260  ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU          
SEQRES  18 I 1260  GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS          
SEQRES  19 I 1260  HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP          
SEQRES  20 I 1260  SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE          
SEQRES  21 I 1260  LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL          
SEQRES  22 I 1260  MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU          
SEQRES  23 I 1260  GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL          
SEQRES  24 I 1260  ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER          
SEQRES  25 I 1260  ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER          
SEQRES  26 I 1260  LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP          
SEQRES  27 I 1260  GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS          
SEQRES  28 I 1260  ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU          
SEQRES  29 I 1260  ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU          
SEQRES  30 I 1260  ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN          
SEQRES  31 I 1260  LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU          
SEQRES  32 I 1260  TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN          
SEQRES  33 I 1260  GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN          
SEQRES  34 I 1260  GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL          
SEQRES  35 I 1260  ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP          
SEQRES  36 I 1260  LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS          
SEQRES  37 I 1260  GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET          
SEQRES  38 I 1260  TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA          
SEQRES  39 I 1260  LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU          
SEQRES  40 I 1260  ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA          
SEQRES  41 I 1260  HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU          
SEQRES  42 I 1260  ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU          
SEQRES  43 I 1260  PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO          
SEQRES  44 I 1260  PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU          
SEQRES  45 I 1260  THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS          
SEQRES  46 I 1260  GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE          
SEQRES  47 I 1260  ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL          
SEQRES  48 I 1260  ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER          
SEQRES  49 I 1260  GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS          
SEQRES  50 I 1260  THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU          
SEQRES  51 I 1260  LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS          
SEQRES  52 I 1260  ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER          
SEQRES  53 I 1260  VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY          
SEQRES  54 I 1260  GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL          
SEQRES  55 I 1260  ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU          
SEQRES  56 I 1260  LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP          
SEQRES  57 I 1260  ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY          
SEQRES  58 I 1260  HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP          
SEQRES  59 I 1260  ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU          
SEQRES  60 I 1260  LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER          
SEQRES  61 I 1260  ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO          
SEQRES  62 I 1260  GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP          
SEQRES  63 I 1260  SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN          
SEQRES  64 I 1260  LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU          
SEQRES  65 I 1260  GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR          
SEQRES  66 I 1260  CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA          
SEQRES  67 I 1260  LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER          
SEQRES  68 I 1260  ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP          
SEQRES  69 I 1260  VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE          
SEQRES  70 I 1260  LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU          
SEQRES  71 I 1260  THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS          
SEQRES  72 I 1260  GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET          
SEQRES  73 I 1260  VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE          
SEQRES  74 I 1260  ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA          
SEQRES  75 I 1260  GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR          
SEQRES  76 I 1260  ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU          
SEQRES  77 I 1260  GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN          
SEQRES  78 I 1260  HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP          
SEQRES  79 I 1260  GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE          
SEQRES  80 I 1260  GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU          
SEQRES  81 I 1260  ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU          
SEQRES  82 I 1260  LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR          
SEQRES  83 I 1260  VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS          
SEQRES  84 I 1260  ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP          
SEQRES  85 I 1260  ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA          
SEQRES  86 I 1260  ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU          
SEQRES  87 I 1260  PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG          
SEQRES  88 I 1260  CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR          
SEQRES  89 I 1260  GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER          
SEQRES  90 I 1260  ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU          
SEQRES  91 I 1260  GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU          
SEQRES  92 I 1260  CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY          
SEQRES  93 I 1260  GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER          
SEQRES  94 I 1260  SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS          
SEQRES  95 I 1260  ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL          
SEQRES  96 I 1260  ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU          
SEQRES  97 I 1260  LEU GLU HIS HIS HIS HIS HIS HIS HIS HIS HIS HIS              
SEQRES   1 J  105  MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN          
SEQRES   2 J  105  LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS          
SEQRES   3 J  105  HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG          
SEQRES   4 J  105  LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA          
SEQRES   5 J  105  ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU          
SEQRES   6 J  105  MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY          
SEQRES   7 J  105  THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU          
SEQRES   8 J  105  ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN          
SEQRES   9 J  105  GLU                                                          
SEQRES   1 K 1260  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 K 1260  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 K 1260  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 K 1260  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 K 1260  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 K 1260  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 K 1260  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 K 1260  PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER          
SEQRES   9 K 1260  GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY          
SEQRES  10 K 1260  GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS          
SEQRES  11 K 1260  LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU          
SEQRES  12 K 1260  LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA          
SEQRES  13 K 1260  GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG          
SEQRES  14 K 1260  ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL          
SEQRES  15 K 1260  HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU          
SEQRES  16 K 1260  LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN          
SEQRES  17 K 1260  ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU          
SEQRES  18 K 1260  GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS          
SEQRES  19 K 1260  HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP          
SEQRES  20 K 1260  SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE          
SEQRES  21 K 1260  LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL          
SEQRES  22 K 1260  MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU          
SEQRES  23 K 1260  GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL          
SEQRES  24 K 1260  ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER          
SEQRES  25 K 1260  ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER          
SEQRES  26 K 1260  LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP          
SEQRES  27 K 1260  GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS          
SEQRES  28 K 1260  ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU          
SEQRES  29 K 1260  ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU          
SEQRES  30 K 1260  ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN          
SEQRES  31 K 1260  LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU          
SEQRES  32 K 1260  TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN          
SEQRES  33 K 1260  GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN          
SEQRES  34 K 1260  GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL          
SEQRES  35 K 1260  ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP          
SEQRES  36 K 1260  LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS          
SEQRES  37 K 1260  GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET          
SEQRES  38 K 1260  TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA          
SEQRES  39 K 1260  LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU          
SEQRES  40 K 1260  ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA          
SEQRES  41 K 1260  HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU          
SEQRES  42 K 1260  ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU          
SEQRES  43 K 1260  PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO          
SEQRES  44 K 1260  PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU          
SEQRES  45 K 1260  THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS          
SEQRES  46 K 1260  GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE          
SEQRES  47 K 1260  ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL          
SEQRES  48 K 1260  ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER          
SEQRES  49 K 1260  GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS          
SEQRES  50 K 1260  THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU          
SEQRES  51 K 1260  LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS          
SEQRES  52 K 1260  ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER          
SEQRES  53 K 1260  VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY          
SEQRES  54 K 1260  GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL          
SEQRES  55 K 1260  ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU          
SEQRES  56 K 1260  LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP          
SEQRES  57 K 1260  ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY          
SEQRES  58 K 1260  HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP          
SEQRES  59 K 1260  ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU          
SEQRES  60 K 1260  LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER          
SEQRES  61 K 1260  ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO          
SEQRES  62 K 1260  GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP          
SEQRES  63 K 1260  SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN          
SEQRES  64 K 1260  LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU          
SEQRES  65 K 1260  GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR          
SEQRES  66 K 1260  CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA          
SEQRES  67 K 1260  LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER          
SEQRES  68 K 1260  ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP          
SEQRES  69 K 1260  VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE          
SEQRES  70 K 1260  LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU          
SEQRES  71 K 1260  THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS          
SEQRES  72 K 1260  GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET          
SEQRES  73 K 1260  VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE          
SEQRES  74 K 1260  ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA          
SEQRES  75 K 1260  GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR          
SEQRES  76 K 1260  ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU          
SEQRES  77 K 1260  GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN          
SEQRES  78 K 1260  HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP          
SEQRES  79 K 1260  GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE          
SEQRES  80 K 1260  GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU          
SEQRES  81 K 1260  ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU          
SEQRES  82 K 1260  LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR          
SEQRES  83 K 1260  VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS          
SEQRES  84 K 1260  ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP          
SEQRES  85 K 1260  ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA          
SEQRES  86 K 1260  ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU          
SEQRES  87 K 1260  PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG          
SEQRES  88 K 1260  CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR          
SEQRES  89 K 1260  GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER          
SEQRES  90 K 1260  ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU          
SEQRES  91 K 1260  GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU          
SEQRES  92 K 1260  CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY          
SEQRES  93 K 1260  GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER          
SEQRES  94 K 1260  SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS          
SEQRES  95 K 1260  ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL          
SEQRES  96 K 1260  ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU          
SEQRES  97 K 1260  LEU GLU HIS HIS HIS HIS HIS HIS HIS HIS HIS HIS              
SEQRES   1 L  105  MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN          
SEQRES   2 L  105  LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS          
SEQRES   3 L  105  HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG          
SEQRES   4 L  105  LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA          
SEQRES   5 L  105  ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU          
SEQRES   6 L  105  MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY          
SEQRES   7 L  105  THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU          
SEQRES   8 L  105  ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN          
SEQRES   9 L  105  GLU                                                          
SEQRES   1 M 1260  MET ASP ALA LYS ALA ARG ASN CYS LEU LEU GLN HIS ARG          
SEQRES   2 M 1260  GLU ALA LEU GLU LYS ASP ILE LYS THR SER TYR ILE MET          
SEQRES   3 M 1260  ASP HIS MET ILE SER ASP GLY PHE LEU THR ILE SER GLU          
SEQRES   4 M 1260  GLU GLU LYS VAL ARG ASN GLU PRO THR GLN GLN GLN ARG          
SEQRES   5 M 1260  ALA ALA MET LEU ILE LYS MET ILE LEU LYS LYS ASP ASN          
SEQRES   6 M 1260  ASP SER TYR VAL SER PHE TYR ASN ALA LEU LEU HIS GLU          
SEQRES   7 M 1260  GLY TYR LYS ASP LEU ALA ALA LEU LEU HIS ASP GLY ILE          
SEQRES   8 M 1260  PRO VAL VAL SER SER SER SER GLY LYS ASP SER VAL SER          
SEQRES   9 M 1260  GLY ILE THR SER TYR VAL ARG THR VAL LEU CYS GLU GLY          
SEQRES  10 M 1260  GLY VAL PRO GLN ARG PRO VAL VAL PHE VAL THR ARG LYS          
SEQRES  11 M 1260  LYS LEU VAL ASN ALA ILE GLN GLN LYS LEU SER LYS LEU          
SEQRES  12 M 1260  LYS GLY GLU PRO GLY TRP VAL THR ILE HIS GLY MET ALA          
SEQRES  13 M 1260  GLY CYS GLY LYS SER VAL LEU ALA ALA GLU ALA VAL ARG          
SEQRES  14 M 1260  ASP HIS SER LEU LEU GLU GLY CYS PHE PRO GLY GLY VAL          
SEQRES  15 M 1260  HIS TRP VAL SER VAL GLY LYS GLN ASP LYS SER GLY LEU          
SEQRES  16 M 1260  LEU MET LYS LEU GLN ASN LEU CYS THR ARG LEU ASP GLN          
SEQRES  17 M 1260  ASP GLU SER PHE SER GLN ARG LEU PRO LEU ASN ILE GLU          
SEQRES  18 M 1260  GLU ALA LYS ASP ARG LEU ARG ILE LEU MET LEU ARG LYS          
SEQRES  19 M 1260  HIS PRO ARG SER LEU LEU ILE LEU ASP ASP VAL TRP ASP          
SEQRES  20 M 1260  SER TRP VAL LEU LYS ALA PHE ASP SER GLN CYS GLN ILE          
SEQRES  21 M 1260  LEU LEU THR THR ARG ASP LYS SER VAL THR ASP SER VAL          
SEQRES  22 M 1260  MET GLY PRO LYS TYR VAL VAL PRO VAL GLU SER SER LEU          
SEQRES  23 M 1260  GLY LYS GLU LYS GLY LEU GLU ILE LEU SER LEU PHE VAL          
SEQRES  24 M 1260  ASN MET LYS LYS ALA ASP LEU PRO GLU GLN ALA HIS SER          
SEQRES  25 M 1260  ILE ILE LYS GLU CYS LYS GLY SER PRO LEU VAL VAL SER          
SEQRES  26 M 1260  LEU ILE GLY ALA LEU LEU ARG ASP PHE PRO ASN ARG TRP          
SEQRES  27 M 1260  GLU TYR TYR LEU LYS GLN LEU GLN ASN LYS GLN PHE LYS          
SEQRES  28 M 1260  ARG ILE ARG LYS SER SER SER TYR ASP TYR GLU ALA LEU          
SEQRES  29 M 1260  ASP GLU ALA MET SER ILE SER VAL GLU MET LEU ARG GLU          
SEQRES  30 M 1260  ASP ILE LYS ASP TYR TYR THR ASP LEU SER ILE LEU GLN          
SEQRES  31 M 1260  LYS ASP VAL LYS VAL PRO THR LYS VAL LEU CYS ILE LEU          
SEQRES  32 M 1260  TRP ASP MET GLU THR GLU GLU VAL GLU ASP ILE LEU GLN          
SEQRES  33 M 1260  GLU PHE VAL ASN LYS SER LEU LEU PHE CYS ASP ARG ASN          
SEQRES  34 M 1260  GLY LYS SER PHE ARG TYR TYR LEU HIS ASP LEU GLN VAL          
SEQRES  35 M 1260  ASP PHE LEU THR GLU LYS ASN CYS SER GLN LEU GLN ASP          
SEQRES  36 M 1260  LEU HIS LYS LYS ILE ILE THR GLN PHE GLN ARG TYR HIS          
SEQRES  37 M 1260  GLN PRO HIS THR LEU SER PRO ASP GLN GLU ASP CYS MET          
SEQRES  38 M 1260  TYR TRP TYR ASN PHE LEU ALA TYR HIS MET ALA SER ALA          
SEQRES  39 M 1260  LYS MET HIS LYS GLU LEU CYS ALA LEU MET PHE SER LEU          
SEQRES  40 M 1260  ASP TRP ILE LYS ALA LYS THR GLU LEU VAL GLY PRO ALA          
SEQRES  41 M 1260  HIS LEU ILE HIS GLU PHE VAL GLU TYR ARG HIS ILE LEU          
SEQRES  42 M 1260  ASP GLU LYS ASP CYS ALA VAL SER GLU ASN PHE GLN GLU          
SEQRES  43 M 1260  PHE LEU SER LEU ASN GLY HIS LEU LEU GLY ARG GLN PRO          
SEQRES  44 M 1260  PHE PRO ASN ILE VAL GLN LEU GLY LEU CYS GLU PRO GLU          
SEQRES  45 M 1260  THR SER GLU VAL TYR GLN GLN ALA LYS LEU GLN ALA LYS          
SEQRES  46 M 1260  GLN GLU VAL ASP ASN GLY MET LEU TYR LEU GLU TRP ILE          
SEQRES  47 M 1260  ASN LYS LYS ASN ILE THR ASN LEU SER ARG LEU VAL VAL          
SEQRES  48 M 1260  ARG PRO HIS THR ASP ALA VAL TYR HIS ALA CYS PHE SER          
SEQRES  49 M 1260  GLU ASP GLY GLN ARG ILE ALA SER CYS GLY ALA ASP LYS          
SEQRES  50 M 1260  THR LEU GLN VAL PHE LYS ALA GLU THR GLY GLU LYS LEU          
SEQRES  51 M 1260  LEU GLU ILE LYS ALA HIS GLU ASP GLU VAL LEU CYS CYS          
SEQRES  52 M 1260  ALA PHE SER THR ASP ASP ARG PHE ILE ALA THR CYS SER          
SEQRES  53 M 1260  VAL ASP LYS LYS VAL LYS ILE TRP ASN SER MET THR GLY          
SEQRES  54 M 1260  GLU LEU VAL HIS THR TYR ASP GLU HIS SER GLU GLN VAL          
SEQRES  55 M 1260  ASN CYS CYS HIS PHE THR ASN SER SER HIS HIS LEU LEU          
SEQRES  56 M 1260  LEU ALA THR GLY SER SER ASP CYS PHE LEU LYS LEU TRP          
SEQRES  57 M 1260  ASP LEU ASN GLN LYS GLU CYS ARG ASN THR MET PHE GLY          
SEQRES  58 M 1260  HIS THR ASN SER VAL ASN HIS CYS ARG PHE SER PRO ASP          
SEQRES  59 M 1260  ASP LYS LEU LEU ALA SER CYS SER ALA ASP GLY THR LEU          
SEQRES  60 M 1260  LYS LEU TRP ASP ALA THR SER ALA ASN GLU ARG LYS SER          
SEQRES  61 M 1260  ILE ASN VAL LYS GLN PHE PHE LEU ASN LEU GLU ASP PRO          
SEQRES  62 M 1260  GLN GLU ASP MET GLU VAL ILE VAL LYS CYS CYS SER TRP          
SEQRES  63 M 1260  SER ALA ASP GLY ALA ARG ILE MET VAL ALA ALA LYS ASN          
SEQRES  64 M 1260  LYS ILE PHE LEU PHE ASP ILE HIS THR SER GLY LEU LEU          
SEQRES  65 M 1260  GLY GLU ILE HIS THR GLY HIS HIS SER THR ILE GLN TYR          
SEQRES  66 M 1260  CYS ASP PHE SER PRO GLN ASN HIS LEU ALA VAL VAL ALA          
SEQRES  67 M 1260  LEU SER GLN TYR CYS VAL GLU LEU TRP ASN THR ASP SER          
SEQRES  68 M 1260  ARG SER LYS VAL ALA ASP CYS ARG GLY HIS LEU SER TRP          
SEQRES  69 M 1260  VAL HIS GLY VAL MET PHE SER PRO ASP GLY SER SER PHE          
SEQRES  70 M 1260  LEU THR SER SER ASP ASP GLN THR ILE ARG LEU TRP GLU          
SEQRES  71 M 1260  THR LYS LYS VAL CYS LYS ASN SER ALA VAL MET LEU LYS          
SEQRES  72 M 1260  GLN GLU VAL ASP VAL VAL PHE GLN GLU ASN GLU VAL MET          
SEQRES  73 M 1260  VAL LEU ALA VAL ASP HIS ILE ARG ARG LEU GLN LEU ILE          
SEQRES  74 M 1260  ASN GLY ARG THR GLY GLN ILE ASP TYR LEU THR GLU ALA          
SEQRES  75 M 1260  GLN VAL SER CYS CYS CYS LEU SER PRO HIS LEU GLN TYR          
SEQRES  76 M 1260  ILE ALA PHE GLY ASP GLU ASN GLY ALA ILE GLU ILE LEU          
SEQRES  77 M 1260  GLU LEU VAL ASN ASN ARG ILE PHE GLN SER ARG PHE GLN          
SEQRES  78 M 1260  HIS LYS LYS THR VAL TRP HIS ILE GLN PHE THR ALA ASP          
SEQRES  79 M 1260  GLU LYS THR LEU ILE SER SER SER ASP ASP ALA GLU ILE          
SEQRES  80 M 1260  GLN VAL TRP ASN TRP GLN LEU ASP LYS CYS ILE PHE LEU          
SEQRES  81 M 1260  ARG GLY HIS GLN GLU THR VAL LYS ASP PHE ARG LEU LEU          
SEQRES  82 M 1260  LYS ASN SER ARG LEU LEU SER TRP SER PHE ASP GLY THR          
SEQRES  83 M 1260  VAL LYS VAL TRP ASN ILE ILE THR GLY ASN LYS GLU LYS          
SEQRES  84 M 1260  ASP PHE VAL CYS HIS GLN GLY THR VAL LEU SER CYS ASP          
SEQRES  85 M 1260  ILE SER HIS ASP ALA THR LYS PHE SER SER THR SER ALA          
SEQRES  86 M 1260  ASP LYS THR ALA LYS ILE TRP SER PHE ASP LEU LEU LEU          
SEQRES  87 M 1260  PRO LEU HIS GLU LEU ARG GLY HIS ASN GLY CYS VAL ARG          
SEQRES  88 M 1260  CYS SER ALA PHE SER VAL ASP SER THR LEU LEU ALA THR          
SEQRES  89 M 1260  GLY ASP ASP ASN GLY GLU ILE ARG ILE TRP ASN VAL SER          
SEQRES  90 M 1260  ASN GLY GLU LEU LEU HIS LEU CYS ALA PRO LEU SER GLU          
SEQRES  91 M 1260  GLU GLY ALA ALA THR HIS GLY GLY TRP VAL THR ASP LEU          
SEQRES  92 M 1260  CYS PHE SER PRO ASP GLY LYS MET LEU ILE SER ALA GLY          
SEQRES  93 M 1260  GLY TYR ILE LYS TRP TRP ASN VAL VAL THR GLY GLU SER          
SEQRES  94 M 1260  SER GLN THR PHE TYR THR ASN GLY THR ASN LEU LYS LYS          
SEQRES  95 M 1260  ILE HIS VAL SER PRO ASP PHE LYS THR TYR VAL THR VAL          
SEQRES  96 M 1260  ASP ASN LEU GLY ILE LEU TYR ILE LEU GLN THR LEU GLU          
SEQRES  97 M 1260  LEU GLU HIS HIS HIS HIS HIS HIS HIS HIS HIS HIS              
SEQRES   1 N  105  MET GLY ASP VAL GLU LYS GLY LYS LYS ILE PHE VAL GLN          
SEQRES   2 N  105  LYS CYS ALA GLN CYS HIS THR VAL GLU LYS GLY GLY LYS          
SEQRES   3 N  105  HIS LYS THR GLY PRO ASN LEU HIS GLY LEU PHE GLY ARG          
SEQRES   4 N  105  LYS THR GLY GLN ALA PRO GLY PHE THR TYR THR ASP ALA          
SEQRES   5 N  105  ASN LYS ASN LYS GLY ILE THR TRP LYS GLU GLU THR LEU          
SEQRES   6 N  105  MET GLU TYR LEU GLU ASN PRO LYS LYS TYR ILE PRO GLY          
SEQRES   7 N  105  THR LYS MET ILE PHE ALA GLY ILE LYS LYS LYS THR GLU          
SEQRES   8 N  105  ARG GLU ASP LEU ILE ALA TYR LEU LYS LYS ALA THR ASN          
SEQRES   9 N  105  GLU                                                          
HET    DTP  A1301      30                                                       
HET     MG  A1302       1                                                       
HET    HEM  B 201      43                                                       
HET    DTP  C1301      30                                                       
HET     MG  C1302       1                                                       
HET    HEM  D 201      43                                                       
HET    DTP  E1301      30                                                       
HET     MG  E1302       1                                                       
HET    HEM  F 201      43                                                       
HET    DTP  G1301      30                                                       
HET     MG  G1302       1                                                       
HET    HEM  H 201      43                                                       
HET    DTP  I1301      30                                                       
HET     MG  I1302       1                                                       
HET    HEM  J 201      43                                                       
HET    DTP  K1301      30                                                       
HET     MG  K1302       1                                                       
HET    HEM  L 201      43                                                       
HET    DTP  M1301      30                                                       
HET     MG  M1302       1                                                       
HET    HEM  N 201      43                                                       
HETNAM     DTP 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE                                
HETNAM      MG MAGNESIUM ION                                                    
HETNAM     HEM PROTOPORPHYRIN IX CONTAINING FE                                  
HETSYN     HEM HEME                                                             
FORMUL  15  DTP    7(C10 H16 N5 O12 P3)                                         
FORMUL  16   MG    7(MG 2+)                                                     
FORMUL  17  HEM    7(C34 H32 FE N4 O4)                                          
HELIX    1   1 THR A  107  GLY A  118  1                                  12    
HELIX    2   2 ARG A  129  LEU A  143  1                                  15    
HELIX    3   3 GLY A  159  ASP A  170  1                                  12    
HELIX    4   4 ASP A  170  PHE A  178  1                                   9    
HELIX    5   5 ASP A  191  ASP A  207  1                                  17    
HELIX    6   6 ASN A  219  ARG A  233  1                                  15    
HELIX    7   7 ASP A  247  ASP A  255  1                                   9    
HELIX    8   8 GLY A  287  ASN A  300  1                                  14    
HELIX    9   9 PRO A  307  LYS A  318  1                                  12    
HELIX   10  10 SER A  320  PHE A  334  1                                  15    
HELIX   11  11 ARG A  337  LYS A  348  1                                  12    
HELIX   12  12 ALA A  363  MET A  374  1                                  12    
HELIX   13  13 ARG A  376  LEU A  386  1                                  11    
HELIX   14  14 THR A  397  ASP A  405  1                                   9    
HELIX   15  15 GLU A  407  LYS A  421  1                                  15    
HELIX   16  16 HIS A  438  TYR A  467  1                                  30    
HELIX   17  17 ASP A  479  LYS A  495  1                                  17    
HELIX   18  18 MET A  496  MET A  504  1                                   9    
HELIX   19  19 SER A  506  VAL A  517  1                                  12    
HELIX   20  20 ALA A  520  LEU A  533  1                                  14    
HELIX   21  21 ASP A  534  LEU A  550  1                                  17    
HELIX   22  22 LEU A  550  LEU A  555  1                                   6    
HELIX   23  23 ASN A  562  GLY A  567  1                                   6    
HELIX   24  24 GLU A  575  GLY A  591  1                                  17    
HELIX   25  25 ASN A  599  ILE A  603  5                                   5    
HELIX   26  26 PRO A  850  ASN A  852  5                                   3    
HELIX   27  27 THR A  911  LYS A  916  1                                   6    
HELIX   28  28 ASP B    2  CYS B   14  1                                  13    
HELIX   29  29 THR B   49  LYS B   55  1                                   7    
HELIX   30  30 LYS B   60  ASN B   70  1                                  11    
HELIX   31  31 ASN B   70  ILE B   75  1                                   6    
HELIX   32  32 LYS B   87  THR B  102  1                                  16    
HELIX   33  33 THR C  107  GLY C  118  1                                  12    
HELIX   34  34 ARG C  129  LEU C  143  1                                  15    
HELIX   35  35 GLY C  159  ASP C  170  1                                  12    
HELIX   36  36 ASP C  170  PHE C  178  1                                   9    
HELIX   37  37 ASP C  191  ASP C  207  1                                  17    
HELIX   38  38 ASN C  219  ARG C  233  1                                  15    
HELIX   39  39 ASP C  247  ASP C  255  1                                   9    
HELIX   40  40 GLY C  287  ASN C  300  1                                  14    
HELIX   41  41 PRO C  307  LYS C  318  1                                  12    
HELIX   42  42 SER C  320  PHE C  334  1                                  15    
HELIX   43  43 ARG C  337  LYS C  348  1                                  12    
HELIX   44  44 ALA C  363  MET C  374  1                                  12    
HELIX   45  45 ARG C  376  LEU C  386  1                                  11    
HELIX   46  46 THR C  397  ASP C  405  1                                   9    
HELIX   47  47 GLU C  407  LYS C  421  1                                  15    
HELIX   48  48 HIS C  438  TYR C  467  1                                  30    
HELIX   49  49 ASP C  479  LYS C  495  1                                  17    
HELIX   50  50 MET C  496  MET C  504  1                                   9    
HELIX   51  51 SER C  506  VAL C  517  1                                  12    
HELIX   52  52 ALA C  520  LEU C  533  1                                  14    
HELIX   53  53 ASP C  534  LEU C  550  1                                  17    
HELIX   54  54 LEU C  550  LEU C  555  1                                   6    
HELIX   55  55 ASN C  562  GLY C  567  1                                   6    
HELIX   56  56 GLU C  575  GLY C  591  1                                  17    
HELIX   57  57 ASN C  599  ILE C  603  5                                   5    
HELIX   58  58 PRO C  850  ASN C  852  5                                   3    
HELIX   59  59 THR C  911  LYS C  916  1                                   6    
HELIX   60  60 ASP D    2  CYS D   14  1                                  13    
HELIX   61  61 THR D   49  LYS D   55  1                                   7    
HELIX   62  62 LYS D   60  ASN D   70  1                                  11    
HELIX   63  63 ASN D   70  ILE D   75  1                                   6    
HELIX   64  64 LYS D   87  THR D  102  1                                  16    
HELIX   65  65 THR E  107  GLY E  118  1                                  12    
HELIX   66  66 ARG E  129  LEU E  143  1                                  15    
HELIX   67  67 GLY E  159  ASP E  170  1                                  12    
HELIX   68  68 ASP E  170  PHE E  178  1                                   9    
HELIX   69  69 ASP E  191  ASP E  207  1                                  17    
HELIX   70  70 ASN E  219  ARG E  233  1                                  15    
HELIX   71  71 ASP E  247  ASP E  255  1                                   9    
HELIX   72  72 GLY E  287  ASN E  300  1                                  14    
HELIX   73  73 PRO E  307  LYS E  318  1                                  12    
HELIX   74  74 SER E  320  PHE E  334  1                                  15    
HELIX   75  75 ARG E  337  LYS E  348  1                                  12    
HELIX   76  76 ALA E  363  MET E  374  1                                  12    
HELIX   77  77 ARG E  376  LEU E  386  1                                  11    
HELIX   78  78 THR E  397  ASP E  405  1                                   9    
HELIX   79  79 GLU E  407  LYS E  421  1                                  15    
HELIX   80  80 HIS E  438  TYR E  467  1                                  30    
HELIX   81  81 ASP E  479  LYS E  495  1                                  17    
HELIX   82  82 MET E  496  MET E  504  1                                   9    
HELIX   83  83 SER E  506  VAL E  517  1                                  12    
HELIX   84  84 ALA E  520  LEU E  533  1                                  14    
HELIX   85  85 ASP E  534  LEU E  550  1                                  17    
HELIX   86  86 LEU E  550  LEU E  555  1                                   6    
HELIX   87  87 ASN E  562  GLY E  567  1                                   6    
HELIX   88  88 GLU E  575  GLY E  591  1                                  17    
HELIX   89  89 ASN E  599  ILE E  603  5                                   5    
HELIX   90  90 PRO E  850  ASN E  852  5                                   3    
HELIX   91  91 THR E  911  LYS E  916  1                                   6    
HELIX   92  92 ASP F    2  CYS F   14  1                                  13    
HELIX   93  93 THR F   49  LYS F   55  1                                   7    
HELIX   94  94 LYS F   60  ASN F   70  1                                  11    
HELIX   95  95 ASN F   70  ILE F   75  1                                   6    
HELIX   96  96 LYS F   87  THR F  102  1                                  16    
HELIX   97  97 THR G  107  GLY G  118  1                                  12    
HELIX   98  98 ARG G  129  LEU G  143  1                                  15    
HELIX   99  99 GLY G  159  ASP G  170  1                                  12    
HELIX  100 100 ASP G  170  PHE G  178  1                                   9    
HELIX  101 101 ASP G  191  ASP G  207  1                                  17    
HELIX  102 102 ASN G  219  ARG G  233  1                                  15    
HELIX  103 103 ASP G  247  ASP G  255  1                                   9    
HELIX  104 104 GLY G  287  ASN G  300  1                                  14    
HELIX  105 105 PRO G  307  LYS G  318  1                                  12    
HELIX  106 106 SER G  320  PHE G  334  1                                  15    
HELIX  107 107 ARG G  337  LYS G  348  1                                  12    
HELIX  108 108 ALA G  363  MET G  374  1                                  12    
HELIX  109 109 ARG G  376  LEU G  386  1                                  11    
HELIX  110 110 THR G  397  ASP G  405  1                                   9    
HELIX  111 111 GLU G  407  LYS G  421  1                                  15    
HELIX  112 112 HIS G  438  TYR G  467  1                                  30    
HELIX  113 113 ASP G  479  LYS G  495  1                                  17    
HELIX  114 114 MET G  496  MET G  504  1                                   9    
HELIX  115 115 SER G  506  VAL G  517  1                                  12    
HELIX  116 116 ALA G  520  LEU G  533  1                                  14    
HELIX  117 117 ASP G  534  LEU G  550  1                                  17    
HELIX  118 118 LEU G  550  LEU G  555  1                                   6    
HELIX  119 119 ASN G  562  GLY G  567  1                                   6    
HELIX  120 120 GLU G  575  GLY G  591  1                                  17    
HELIX  121 121 ASN G  599  ILE G  603  5                                   5    
HELIX  122 122 PRO G  850  ASN G  852  5                                   3    
HELIX  123 123 THR G  911  LYS G  916  1                                   6    
HELIX  124 124 ASP H    2  CYS H   14  1                                  13    
HELIX  125 125 THR H   49  LYS H   55  1                                   7    
HELIX  126 126 LYS H   60  ASN H   70  1                                  11    
HELIX  127 127 ASN H   70  ILE H   75  1                                   6    
HELIX  128 128 LYS H   87  THR H  102  1                                  16    
HELIX  129 129 THR I  107  GLY I  118  1                                  12    
HELIX  130 130 ARG I  129  LEU I  143  1                                  15    
HELIX  131 131 GLY I  159  ASP I  170  1                                  12    
HELIX  132 132 ASP I  170  PHE I  178  1                                   9    
HELIX  133 133 ASP I  191  ASP I  207  1                                  17    
HELIX  134 134 ASN I  219  ARG I  233  1                                  15    
HELIX  135 135 ASP I  247  ASP I  255  1                                   9    
HELIX  136 136 GLY I  287  ASN I  300  1                                  14    
HELIX  137 137 PRO I  307  LYS I  318  1                                  12    
HELIX  138 138 SER I  320  PHE I  334  1                                  15    
HELIX  139 139 ARG I  337  LYS I  348  1                                  12    
HELIX  140 140 ALA I  363  MET I  374  1                                  12    
HELIX  141 141 ARG I  376  LEU I  386  1                                  11    
HELIX  142 142 THR I  397  ASP I  405  1                                   9    
HELIX  143 143 GLU I  407  LYS I  421  1                                  15    
HELIX  144 144 HIS I  438  TYR I  467  1                                  30    
HELIX  145 145 ASP I  479  LYS I  495  1                                  17    
HELIX  146 146 MET I  496  MET I  504  1                                   9    
HELIX  147 147 SER I  506  VAL I  517  1                                  12    
HELIX  148 148 ALA I  520  LEU I  533  1                                  14    
HELIX  149 149 ASP I  534  LEU I  550  1                                  17    
HELIX  150 150 LEU I  550  LEU I  555  1                                   6    
HELIX  151 151 ASN I  562  GLY I  567  1                                   6    
HELIX  152 152 GLU I  575  GLY I  591  1                                  17    
HELIX  153 153 ASN I  599  ILE I  603  5                                   5    
HELIX  154 154 PRO I  850  ASN I  852  5                                   3    
HELIX  155 155 THR I  911  LYS I  916  1                                   6    
HELIX  156 156 ASP J    2  CYS J   14  1                                  13    
HELIX  157 157 THR J   49  LYS J   55  1                                   7    
HELIX  158 158 LYS J   60  ASN J   70  1                                  11    
HELIX  159 159 ASN J   70  ILE J   75  1                                   6    
HELIX  160 160 LYS J   87  THR J  102  1                                  16    
HELIX  161 161 THR K  107  GLY K  118  1                                  12    
HELIX  162 162 ARG K  129  LEU K  143  1                                  15    
HELIX  163 163 GLY K  159  ASP K  170  1                                  12    
HELIX  164 164 ASP K  170  PHE K  178  1                                   9    
HELIX  165 165 ASP K  191  ASP K  207  1                                  17    
HELIX  166 166 ASN K  219  ARG K  233  1                                  15    
HELIX  167 167 ASP K  247  ASP K  255  1                                   9    
HELIX  168 168 GLY K  287  ASN K  300  1                                  14    
HELIX  169 169 PRO K  307  LYS K  318  1                                  12    
HELIX  170 170 SER K  320  PHE K  334  1                                  15    
HELIX  171 171 ARG K  337  LYS K  348  1                                  12    
HELIX  172 172 ALA K  363  MET K  374  1                                  12    
HELIX  173 173 ARG K  376  LEU K  386  1                                  11    
HELIX  174 174 THR K  397  ASP K  405  1                                   9    
HELIX  175 175 GLU K  407  LYS K  421  1                                  15    
HELIX  176 176 HIS K  438  TYR K  467  1                                  30    
HELIX  177 177 ASP K  479  LYS K  495  1                                  17    
HELIX  178 178 MET K  496  MET K  504  1                                   9    
HELIX  179 179 SER K  506  VAL K  517  1                                  12    
HELIX  180 180 ALA K  520  LEU K  533  1                                  14    
HELIX  181 181 ASP K  534  LEU K  550  1                                  17    
HELIX  182 182 LEU K  550  LEU K  555  1                                   6    
HELIX  183 183 ASN K  562  GLY K  567  1                                   6    
HELIX  184 184 GLU K  575  GLY K  591  1                                  17    
HELIX  185 185 ASN K  599  ILE K  603  5                                   5    
HELIX  186 186 PRO K  850  ASN K  852  5                                   3    
HELIX  187 187 THR K  911  LYS K  916  1                                   6    
HELIX  188 188 ASP L    2  CYS L   14  1                                  13    
HELIX  189 189 THR L   49  LYS L   55  1                                   7    
HELIX  190 190 LYS L   60  ASN L   70  1                                  11    
HELIX  191 191 ASN L   70  ILE L   75  1                                   6    
HELIX  192 192 LYS L   87  THR L  102  1                                  16    
HELIX  193 193 THR M  107  GLY M  118  1                                  12    
HELIX  194 194 ARG M  129  LEU M  143  1                                  15    
HELIX  195 195 GLY M  159  ASP M  170  1                                  12    
HELIX  196 196 ASP M  170  PHE M  178  1                                   9    
HELIX  197 197 ASP M  191  ASP M  207  1                                  17    
HELIX  198 198 ASN M  219  ARG M  233  1                                  15    
HELIX  199 199 ASP M  247  ASP M  255  1                                   9    
HELIX  200 200 GLY M  287  ASN M  300  1                                  14    
HELIX  201 201 PRO M  307  LYS M  318  1                                  12    
HELIX  202 202 SER M  320  PHE M  334  1                                  15    
HELIX  203 203 ARG M  337  LYS M  348  1                                  12    
HELIX  204 204 ALA M  363  MET M  374  1                                  12    
HELIX  205 205 ARG M  376  LEU M  386  1                                  11    
HELIX  206 206 THR M  397  ASP M  405  1                                   9    
HELIX  207 207 GLU M  407  LYS M  421  1                                  15    
HELIX  208 208 HIS M  438  TYR M  467  1                                  30    
HELIX  209 209 ASP M  479  LYS M  495  1                                  17    
HELIX  210 210 MET M  496  MET M  504  1                                   9    
HELIX  211 211 SER M  506  VAL M  517  1                                  12    
HELIX  212 212 ALA M  520  LEU M  533  1                                  14    
HELIX  213 213 ASP M  534  LEU M  550  1                                  17    
HELIX  214 214 LEU M  550  LEU M  555  1                                   6    
HELIX  215 215 ASN M  562  GLY M  567  1                                   6    
HELIX  216 216 GLU M  575  GLY M  591  1                                  17    
HELIX  217 217 ASN M  599  ILE M  603  5                                   5    
HELIX  218 218 PRO M  850  ASN M  852  5                                   3    
HELIX  219 219 THR M  911  LYS M  916  1                                   6    
HELIX  220 220 ASP N    2  CYS N   14  1                                  13    
HELIX  221 221 THR N   49  LYS N   55  1                                   7    
HELIX  222 222 LYS N   60  ASN N   70  1                                  11    
HELIX  223 223 ASN N   70  ILE N   75  1                                   6    
HELIX  224 224 LYS N   87  THR N  102  1                                  16    
SHEET    1   A 5 VAL A 182  GLY A 188  0                                        
SHEET    2   A 5 LEU A 239  ASP A 244  1  O  ILE A 241   N  VAL A 185           
SHEET    3   A 5 ILE A 260  THR A 264  1  O  LEU A 261   N  LEU A 240           
SHEET    4   A 5 TRP A 149  HIS A 153  1  N  ILE A 152   O  THR A 264           
SHEET    5   A 5 LYS A 277  PRO A 281  1  O  TYR A 278   N  THR A 151           
SHEET    1   B 2 VAL A 395  PRO A 396  0                                        
SHEET    2   B 2 ARG A 434  TYR A 435 -1  O  TYR A 435   N  VAL A 395           
SHEET    1   C 4 LEU A 609  VAL A 611  0                                        
SHEET    2   C 4 ILE A 906  GLU A 910 -1  O  ILE A 906   N  VAL A 611           
SHEET    3   C 4 SER A 896  SER A 901 -1  N  PHE A 897   O  TRP A 909           
SHEET    4   C 4 VAL A 885  PHE A 890 -1  N  GLY A 887   O  SER A 900           
SHEET    1   D 4 ALA A 621  PHE A 623  0                                        
SHEET    2   D 4 ILE A 630  SER A 632 -1  O  ALA A 631   N  CYS A 622           
SHEET    3   D 4 GLN A 640  LYS A 643 -1  O  PHE A 642   N  ILE A 630           
SHEET    4   D 4 GLU A 648  GLU A 652 -1  O  LEU A 650   N  VAL A 641           
SHEET    1   E 4 VAL A 660  PHE A 665  0                                        
SHEET    2   E 4 PHE A 671  SER A 676 -1  O  CYS A 675   N  CYS A 662           
SHEET    3   E 4 VAL A 681  ASN A 685 -1  O  TRP A 684   N  ILE A 672           
SHEET    4   E 4 LEU A 691  TYR A 695 -1  O  TYR A 695   N  VAL A 681           
SHEET    1   F 4 VAL A 702  PHE A 707  0                                        
SHEET    2   F 4 LEU A 715  SER A 720 -1  O  GLY A 719   N  ASN A 703           
SHEET    3   F 4 LEU A 725  ASP A 729 -1  O  TRP A 728   N  LEU A 716           
SHEET    4   F 4 CYS A 735  MET A 739 -1  O  ASN A 737   N  LEU A 727           
SHEET    1   G 4 VAL A 746  CYS A 749  0                                        
SHEET    2   G 4 LEU A 757  SER A 762 -1  O  CYS A 761   N  HIS A 748           
SHEET    3   G 4 LYS A 768  ASP A 771 -1  O  TRP A 770   N  LEU A 758           
SHEET    4   G 4 ASN A 776  LYS A 779 -1  O  LYS A 779   N  LEU A 769           
SHEET    1   H 4 CYS A 804  TRP A 806  0                                        
SHEET    2   H 4 ILE A 813  ALA A 817 -1  O  MET A 814   N  SER A 805           
SHEET    3   H 4 LYS A 820  ASP A 825 -1  O  PHE A 822   N  VAL A 815           
SHEET    4   H 4 GLY A 830  GLY A 833 -1  O  GLY A 830   N  ASP A 825           
SHEET    1   I 3 LEU A 854  ALA A 858  0                                        
SHEET    2   I 3 VAL A 864  ASN A 868 -1  O  TRP A 867   N  ALA A 855           
SHEET    3   I 3 SER A 873  ALA A 876 -1  O  VAL A 875   N  LEU A 866           
SHEET    1   J 3 VAL A 928  PHE A 930  0                                        
SHEET    2   J 3 VAL A 935  VAL A 937 -1  O  MET A 936   N  VAL A 929           
SHEET    3   J 3 ILE A 949  ASN A 950 -1  O  ILE A 949   N  VAL A 937           
SHEET    1   K 2 LEU A 946  GLN A 947  0                                        
SHEET    2   K 2 TYR A 958  LEU A 959 -1  O  LEU A 959   N  LEU A 946           
SHEET    1   L 2 CYS A 967  LEU A 969  0                                        
SHEET    2   L 2 ILE A 976  PHE A 978 -1  O  ALA A 977   N  CYS A 968           
SHEET    1   M 2 ILE A 985  GLU A 986  0                                        
SHEET    2   M 2 SER A 998  ARG A 999 -1  O  ARG A 999   N  ILE A 985           
SHEET    1   N 4 ILE A1009  PHE A1011  0                                        
SHEET    2   N 4 LEU A1018  SER A1020 -1  O  ILE A1019   N  GLN A1010           
SHEET    3   N 4 ILE A1027  ASN A1031 -1  O  GLN A1028   N  SER A1020           
SHEET    4   N 4 LYS A1036  LEU A1040 -1  O  LEU A1040   N  ILE A1027           
SHEET    1   O 4 ASP A1049  LEU A1052  0                                        
SHEET    2   O 4 ARG A1057  TRP A1061 -1  O  TRP A1061   N  ASP A1049           
SHEET    3   O 4 VAL A1067  ASN A1071 -1  O  TRP A1070   N  LEU A1058           
SHEET    4   O 4 LYS A1079  PHE A1081 -1  O  PHE A1081   N  VAL A1067           
SHEET    1   P 4 SER A1090  ILE A1093  0                                        
SHEET    2   P 4 SER A1101  SER A1104 -1  O  SER A1102   N  ASP A1092           
SHEET    3   P 4 ALA A1109  TRP A1112 -1  O  TRP A1112   N  SER A1101           
SHEET    4   P 4 HIS A1121  LEU A1123 -1  O  HIS A1121   N  ILE A1111           
SHEET    1   Q 2 CYS A1132  PHE A1135  0                                        
SHEET    2   Q 2 LEU A1142  GLY A1145 -1  O  GLY A1145   N  CYS A1132           
SHEET    1   R 3 ASP A1182  PHE A1185  0                                        
SHEET    2   R 3 MET A1191  ALA A1195 -1  O  ILE A1193   N  CYS A1184           
SHEET    3   R 3 ILE A1199  ASN A1203 -1  O  LYS A1200   N  SER A1194           
SHEET    1   S 2 VAL A1233  VAL A1235  0                                        
SHEET    2   S 2 LEU A1241  ILE A1243 -1  O  TYR A1242   N  THR A1234           
SHEET    1   T 5 VAL C 182  GLY C 188  0                                        
SHEET    2   T 5 LEU C 239  ASP C 244  1  O  ILE C 241   N  VAL C 185           
SHEET    3   T 5 ILE C 260  THR C 264  1  O  LEU C 261   N  LEU C 240           
SHEET    4   T 5 TRP C 149  HIS C 153  1  N  ILE C 152   O  THR C 264           
SHEET    5   T 5 LYS C 277  PRO C 281  1  O  TYR C 278   N  THR C 151           
SHEET    1   U 2 VAL C 395  PRO C 396  0                                        
SHEET    2   U 2 ARG C 434  TYR C 435 -1  O  TYR C 435   N  VAL C 395           
SHEET    1   V 4 LEU C 609  VAL C 611  0                                        
SHEET    2   V 4 ILE C 906  GLU C 910 -1  O  ILE C 906   N  VAL C 611           
SHEET    3   V 4 SER C 896  SER C 901 -1  N  PHE C 897   O  TRP C 909           
SHEET    4   V 4 VAL C 885  PHE C 890 -1  N  GLY C 887   O  SER C 900           
SHEET    1   W 4 ALA C 621  PHE C 623  0                                        
SHEET    2   W 4 ILE C 630  SER C 632 -1  O  ALA C 631   N  CYS C 622           
SHEET    3   W 4 GLN C 640  LYS C 643 -1  O  PHE C 642   N  ILE C 630           
SHEET    4   W 4 GLU C 648  GLU C 652 -1  O  LEU C 650   N  VAL C 641           
SHEET    1   X 4 VAL C 660  PHE C 665  0                                        
SHEET    2   X 4 PHE C 671  SER C 676 -1  O  CYS C 675   N  CYS C 662           
SHEET    3   X 4 VAL C 681  ASN C 685 -1  O  TRP C 684   N  ILE C 672           
SHEET    4   X 4 LEU C 691  TYR C 695 -1  O  TYR C 695   N  VAL C 681           
SHEET    1   Y 4 VAL C 702  PHE C 707  0                                        
SHEET    2   Y 4 LEU C 715  SER C 720 -1  O  GLY C 719   N  ASN C 703           
SHEET    3   Y 4 LEU C 725  ASP C 729 -1  O  TRP C 728   N  LEU C 716           
SHEET    4   Y 4 CYS C 735  MET C 739 -1  O  ASN C 737   N  LEU C 727           
SHEET    1   Z 4 VAL C 746  CYS C 749  0                                        
SHEET    2   Z 4 LEU C 757  SER C 762 -1  O  CYS C 761   N  HIS C 748           
SHEET    3   Z 4 LYS C 768  ASP C 771 -1  O  TRP C 770   N  LEU C 758           
SHEET    4   Z 4 ASN C 776  LYS C 779 -1  O  LYS C 779   N  LEU C 769           
SHEET    1  AA 4 CYS C 804  TRP C 806  0                                        
SHEET    2  AA 4 ILE C 813  ALA C 817 -1  O  MET C 814   N  SER C 805           
SHEET    3  AA 4 LYS C 820  ASP C 825 -1  O  PHE C 822   N  VAL C 815           
SHEET    4  AA 4 GLY C 830  GLY C 833 -1  O  GLY C 830   N  ASP C 825           
SHEET    1  AB 3 LEU C 854  ALA C 858  0                                        
SHEET    2  AB 3 VAL C 864  ASN C 868 -1  O  TRP C 867   N  ALA C 855           
SHEET    3  AB 3 SER C 873  ALA C 876 -1  O  VAL C 875   N  LEU C 866           
SHEET    1  AC 3 VAL C 928  PHE C 930  0                                        
SHEET    2  AC 3 VAL C 935  VAL C 937 -1  O  MET C 936   N  VAL C 929           
SHEET    3  AC 3 ILE C 949  ASN C 950 -1  O  ILE C 949   N  VAL C 937           
SHEET    1  AD 2 LEU C 946  GLN C 947  0                                        
SHEET    2  AD 2 TYR C 958  LEU C 959 -1  O  LEU C 959   N  LEU C 946           
SHEET    1  AE 2 CYS C 967  LEU C 969  0                                        
SHEET    2  AE 2 ILE C 976  PHE C 978 -1  O  ALA C 977   N  CYS C 968           
SHEET    1  AF 2 ILE C 985  GLU C 986  0                                        
SHEET    2  AF 2 SER C 998  ARG C 999 -1  O  ARG C 999   N  ILE C 985           
SHEET    1  AG 4 ILE C1009  PHE C1011  0                                        
SHEET    2  AG 4 LEU C1018  SER C1020 -1  O  ILE C1019   N  GLN C1010           
SHEET    3  AG 4 ILE C1027  ASN C1031 -1  O  GLN C1028   N  SER C1020           
SHEET    4  AG 4 LYS C1036  LEU C1040 -1  O  LEU C1040   N  ILE C1027           
SHEET    1  AH 4 ASP C1049  LEU C1052  0                                        
SHEET    2  AH 4 ARG C1057  TRP C1061 -1  O  TRP C1061   N  ASP C1049           
SHEET    3  AH 4 VAL C1067  ASN C1071 -1  O  TRP C1070   N  LEU C1058           
SHEET    4  AH 4 LYS C1079  PHE C1081 -1  O  PHE C1081   N  VAL C1067           
SHEET    1  AI 4 SER C1090  ILE C1093  0                                        
SHEET    2  AI 4 SER C1101  SER C1104 -1  O  SER C1102   N  ASP C1092           
SHEET    3  AI 4 ALA C1109  TRP C1112 -1  O  TRP C1112   N  SER C1101           
SHEET    4  AI 4 HIS C1121  LEU C1123 -1  O  HIS C1121   N  ILE C1111           
SHEET    1  AJ 2 CYS C1132  PHE C1135  0                                        
SHEET    2  AJ 2 LEU C1142  GLY C1145 -1  O  GLY C1145   N  CYS C1132           
SHEET    1  AK 3 ASP C1182  PHE C1185  0                                        
SHEET    2  AK 3 MET C1191  ALA C1195 -1  O  ILE C1193   N  CYS C1184           
SHEET    3  AK 3 ILE C1199  ASN C1203 -1  O  LYS C1200   N  SER C1194           
SHEET    1  AL 2 VAL C1233  VAL C1235  0                                        
SHEET    2  AL 2 LEU C1241  ILE C1243 -1  O  TYR C1242   N  THR C1234           
SHEET    1  AM 5 VAL E 182  GLY E 188  0                                        
SHEET    2  AM 5 LEU E 239  ASP E 244  1  O  ILE E 241   N  VAL E 185           
SHEET    3  AM 5 ILE E 260  THR E 264  1  O  LEU E 261   N  LEU E 240           
SHEET    4  AM 5 TRP E 149  HIS E 153  1  N  ILE E 152   O  THR E 264           
SHEET    5  AM 5 LYS E 277  PRO E 281  1  O  TYR E 278   N  THR E 151           
SHEET    1  AN 2 VAL E 395  PRO E 396  0                                        
SHEET    2  AN 2 ARG E 434  TYR E 435 -1  O  TYR E 435   N  VAL E 395           
SHEET    1  AO 4 LEU E 609  VAL E 611  0                                        
SHEET    2  AO 4 ILE E 906  GLU E 910 -1  O  ILE E 906   N  VAL E 611           
SHEET    3  AO 4 SER E 896  SER E 901 -1  N  PHE E 897   O  TRP E 909           
SHEET    4  AO 4 VAL E 885  PHE E 890 -1  N  GLY E 887   O  SER E 900           
SHEET    1  AP 4 ALA E 621  PHE E 623  0                                        
SHEET    2  AP 4 ILE E 630  SER E 632 -1  O  ALA E 631   N  CYS E 622           
SHEET    3  AP 4 GLN E 640  LYS E 643 -1  O  PHE E 642   N  ILE E 630           
SHEET    4  AP 4 GLU E 648  GLU E 652 -1  O  LEU E 650   N  VAL E 641           
SHEET    1  AQ 4 VAL E 660  PHE E 665  0                                        
SHEET    2  AQ 4 PHE E 671  SER E 676 -1  O  CYS E 675   N  CYS E 662           
SHEET    3  AQ 4 VAL E 681  ASN E 685 -1  O  TRP E 684   N  ILE E 672           
SHEET    4  AQ 4 LEU E 691  TYR E 695 -1  O  TYR E 695   N  VAL E 681           
SHEET    1  AR 4 VAL E 702  PHE E 707  0                                        
SHEET    2  AR 4 LEU E 715  SER E 720 -1  O  GLY E 719   N  ASN E 703           
SHEET    3  AR 4 LEU E 725  ASP E 729 -1  O  TRP E 728   N  LEU E 716           
SHEET    4  AR 4 CYS E 735  MET E 739 -1  O  ASN E 737   N  LEU E 727           
SHEET    1  AS 4 VAL E 746  CYS E 749  0                                        
SHEET    2  AS 4 LEU E 757  SER E 762 -1  O  CYS E 761   N  HIS E 748           
SHEET    3  AS 4 LYS E 768  ASP E 771 -1  O  TRP E 770   N  LEU E 758           
SHEET    4  AS 4 ASN E 776  LYS E 779 -1  O  LYS E 779   N  LEU E 769           
SHEET    1  AT 4 CYS E 804  TRP E 806  0                                        
SHEET    2  AT 4 ILE E 813  ALA E 817 -1  O  MET E 814   N  SER E 805           
SHEET    3  AT 4 LYS E 820  ASP E 825 -1  O  PHE E 822   N  VAL E 815           
SHEET    4  AT 4 GLY E 830  GLY E 833 -1  O  GLY E 830   N  ASP E 825           
SHEET    1  AU 3 LEU E 854  ALA E 858  0                                        
SHEET    2  AU 3 VAL E 864  ASN E 868 -1  O  TRP E 867   N  ALA E 855           
SHEET    3  AU 3 SER E 873  ALA E 876 -1  O  VAL E 875   N  LEU E 866           
SHEET    1  AV 3 VAL E 928  PHE E 930  0                                        
SHEET    2  AV 3 VAL E 935  VAL E 937 -1  O  MET E 936   N  VAL E 929           
SHEET    3  AV 3 ILE E 949  ASN E 950 -1  O  ILE E 949   N  VAL E 937           
SHEET    1  AW 2 LEU E 946  GLN E 947  0                                        
SHEET    2  AW 2 TYR E 958  LEU E 959 -1  O  LEU E 959   N  LEU E 946           
SHEET    1  AX 2 CYS E 967  LEU E 969  0                                        
SHEET    2  AX 2 ILE E 976  PHE E 978 -1  O  ALA E 977   N  CYS E 968           
SHEET    1  AY 2 ILE E 985  GLU E 986  0                                        
SHEET    2  AY 2 SER E 998  ARG E 999 -1  O  ARG E 999   N  ILE E 985           
SHEET    1  AZ 4 ILE E1009  PHE E1011  0                                        
SHEET    2  AZ 4 LEU E1018  SER E1020 -1  O  ILE E1019   N  GLN E1010           
SHEET    3  AZ 4 ILE E1027  ASN E1031 -1  O  GLN E1028   N  SER E1020           
SHEET    4  AZ 4 LYS E1036  LEU E1040 -1  O  LEU E1040   N  ILE E1027           
SHEET    1  BA 4 ASP E1049  LEU E1052  0                                        
SHEET    2  BA 4 ARG E1057  TRP E1061 -1  O  TRP E1061   N  ASP E1049           
SHEET    3  BA 4 VAL E1067  ASN E1071 -1  O  TRP E1070   N  LEU E1058           
SHEET    4  BA 4 LYS E1079  PHE E1081 -1  O  PHE E1081   N  VAL E1067           
SHEET    1  BB 4 SER E1090  ILE E1093  0                                        
SHEET    2  BB 4 SER E1101  SER E1104 -1  O  SER E1102   N  ASP E1092           
SHEET    3  BB 4 ALA E1109  TRP E1112 -1  O  TRP E1112   N  SER E1101           
SHEET    4  BB 4 HIS E1121  LEU E1123 -1  O  HIS E1121   N  ILE E1111           
SHEET    1  BC 2 CYS E1132  PHE E1135  0                                        
SHEET    2  BC 2 LEU E1142  GLY E1145 -1  O  GLY E1145   N  CYS E1132           
SHEET    1  BD 3 ASP E1182  PHE E1185  0                                        
SHEET    2  BD 3 MET E1191  ALA E1195 -1  O  ILE E1193   N  CYS E1184           
SHEET    3  BD 3 ILE E1199  ASN E1203 -1  O  LYS E1200   N  SER E1194           
SHEET    1  BE 2 VAL E1233  VAL E1235  0                                        
SHEET    2  BE 2 LEU E1241  ILE E1243 -1  O  TYR E1242   N  THR E1234           
SHEET    1  BF 5 VAL G 182  GLY G 188  0                                        
SHEET    2  BF 5 LEU G 239  ASP G 244  1  O  ILE G 241   N  VAL G 185           
SHEET    3  BF 5 ILE G 260  THR G 264  1  O  LEU G 261   N  LEU G 240           
SHEET    4  BF 5 TRP G 149  HIS G 153  1  N  ILE G 152   O  THR G 264           
SHEET    5  BF 5 LYS G 277  PRO G 281  1  O  TYR G 278   N  THR G 151           
SHEET    1  BG 2 VAL G 395  PRO G 396  0                                        
SHEET    2  BG 2 ARG G 434  TYR G 435 -1  O  TYR G 435   N  VAL G 395           
SHEET    1  BH 4 LEU G 609  VAL G 611  0                                        
SHEET    2  BH 4 ILE G 906  GLU G 910 -1  O  ILE G 906   N  VAL G 611           
SHEET    3  BH 4 SER G 896  SER G 901 -1  N  PHE G 897   O  TRP G 909           
SHEET    4  BH 4 VAL G 885  PHE G 890 -1  N  GLY G 887   O  SER G 900           
SHEET    1  BI 4 ALA G 621  PHE G 623  0                                        
SHEET    2  BI 4 ILE G 630  SER G 632 -1  O  ALA G 631   N  CYS G 622           
SHEET    3  BI 4 GLN G 640  LYS G 643 -1  O  PHE G 642   N  ILE G 630           
SHEET    4  BI 4 GLU G 648  GLU G 652 -1  O  LEU G 650   N  VAL G 641           
SHEET    1  BJ 4 VAL G 660  PHE G 665  0                                        
SHEET    2  BJ 4 PHE G 671  SER G 676 -1  O  CYS G 675   N  CYS G 662           
SHEET    3  BJ 4 VAL G 681  ASN G 685 -1  O  TRP G 684   N  ILE G 672           
SHEET    4  BJ 4 LEU G 691  TYR G 695 -1  O  TYR G 695   N  VAL G 681           
SHEET    1  BK 4 VAL G 702  PHE G 707  0                                        
SHEET    2  BK 4 LEU G 715  SER G 720 -1  O  GLY G 719   N  ASN G 703           
SHEET    3  BK 4 LEU G 725  ASP G 729 -1  O  TRP G 728   N  LEU G 716           
SHEET    4  BK 4 CYS G 735  MET G 739 -1  O  ASN G 737   N  LEU G 727           
SHEET    1  BL 4 VAL G 746  CYS G 749  0                                        
SHEET    2  BL 4 LEU G 757  SER G 762 -1  O  CYS G 761   N  HIS G 748           
SHEET    3  BL 4 LYS G 768  ASP G 771 -1  O  TRP G 770   N  LEU G 758           
SHEET    4  BL 4 ASN G 776  LYS G 779 -1  O  LYS G 779   N  LEU G 769           
SHEET    1  BM 4 CYS G 804  TRP G 806  0                                        
SHEET    2  BM 4 ILE G 813  ALA G 817 -1  O  MET G 814   N  SER G 805           
SHEET    3  BM 4 LYS G 820  ASP G 825 -1  O  PHE G 822   N  VAL G 815           
SHEET    4  BM 4 GLY G 830  GLY G 833 -1  O  GLY G 830   N  ASP G 825           
SHEET    1  BN 3 LEU G 854  ALA G 858  0                                        
SHEET    2  BN 3 VAL G 864  ASN G 868 -1  O  TRP G 867   N  ALA G 855           
SHEET    3  BN 3 SER G 873  ALA G 876 -1  O  VAL G 875   N  LEU G 866           
SHEET    1  BO 3 VAL G 928  PHE G 930  0                                        
SHEET    2  BO 3 VAL G 935  VAL G 937 -1  O  MET G 936   N  VAL G 929           
SHEET    3  BO 3 ILE G 949  ASN G 950 -1  O  ILE G 949   N  VAL G 937           
SHEET    1  BP 2 LEU G 946  GLN G 947  0                                        
SHEET    2  BP 2 TYR G 958  LEU G 959 -1  O  LEU G 959   N  LEU G 946           
SHEET    1  BQ 2 CYS G 967  LEU G 969  0                                        
SHEET    2  BQ 2 ILE G 976  PHE G 978 -1  O  ALA G 977   N  CYS G 968           
SHEET    1  BR 2 ILE G 985  GLU G 986  0                                        
SHEET    2  BR 2 SER G 998  ARG G 999 -1  O  ARG G 999   N  ILE G 985           
SHEET    1  BS 4 ILE G1009  PHE G1011  0                                        
SHEET    2  BS 4 LEU G1018  SER G1020 -1  O  ILE G1019   N  GLN G1010           
SHEET    3  BS 4 ILE G1027  ASN G1031 -1  O  GLN G1028   N  SER G1020           
SHEET    4  BS 4 LYS G1036  LEU G1040 -1  O  LEU G1040   N  ILE G1027           
SHEET    1  BT 4 ASP G1049  LEU G1052  0                                        
SHEET    2  BT 4 ARG G1057  TRP G1061 -1  O  TRP G1061   N  ASP G1049           
SHEET    3  BT 4 VAL G1067  ASN G1071 -1  O  TRP G1070   N  LEU G1058           
SHEET    4  BT 4 LYS G1079  PHE G1081 -1  O  PHE G1081   N  VAL G1067           
SHEET    1  BU 4 SER G1090  ILE G1093  0                                        
SHEET    2  BU 4 SER G1101  SER G1104 -1  O  SER G1102   N  ASP G1092           
SHEET    3  BU 4 ALA G1109  TRP G1112 -1  O  TRP G1112   N  SER G1101           
SHEET    4  BU 4 HIS G1121  LEU G1123 -1  O  HIS G1121   N  ILE G1111           
SHEET    1  BV 2 CYS G1132  PHE G1135  0                                        
SHEET    2  BV 2 LEU G1142  GLY G1145 -1  O  GLY G1145   N  CYS G1132           
SHEET    1  BW 3 ASP G1182  PHE G1185  0                                        
SHEET    2  BW 3 MET G1191  ALA G1195 -1  O  ILE G1193   N  CYS G1184           
SHEET    3  BW 3 ILE G1199  ASN G1203 -1  O  LYS G1200   N  SER G1194           
SHEET    1  BX 2 VAL G1233  VAL G1235  0                                        
SHEET    2  BX 2 LEU G1241  ILE G1243 -1  O  TYR G1242   N  THR G1234           
SHEET    1  BY 5 VAL I 182  GLY I 188  0                                        
SHEET    2  BY 5 LEU I 239  ASP I 244  1  O  ILE I 241   N  VAL I 185           
SHEET    3  BY 5 ILE I 260  THR I 264  1  O  LEU I 261   N  LEU I 240           
SHEET    4  BY 5 TRP I 149  HIS I 153  1  N  ILE I 152   O  THR I 264           
SHEET    5  BY 5 LYS I 277  PRO I 281  1  O  TYR I 278   N  THR I 151           
SHEET    1  BZ 2 VAL I 395  PRO I 396  0                                        
SHEET    2  BZ 2 ARG I 434  TYR I 435 -1  O  TYR I 435   N  VAL I 395           
SHEET    1  CA 4 LEU I 609  VAL I 611  0                                        
SHEET    2  CA 4 ILE I 906  GLU I 910 -1  O  ILE I 906   N  VAL I 611           
SHEET    3  CA 4 SER I 896  SER I 901 -1  N  PHE I 897   O  TRP I 909           
SHEET    4  CA 4 VAL I 885  PHE I 890 -1  N  GLY I 887   O  SER I 900           
SHEET    1  CB 4 ALA I 621  PHE I 623  0                                        
SHEET    2  CB 4 ILE I 630  SER I 632 -1  O  ALA I 631   N  CYS I 622           
SHEET    3  CB 4 GLN I 640  LYS I 643 -1  O  PHE I 642   N  ILE I 630           
SHEET    4  CB 4 GLU I 648  GLU I 652 -1  O  LEU I 650   N  VAL I 641           
SHEET    1  CC 4 VAL I 660  PHE I 665  0                                        
SHEET    2  CC 4 PHE I 671  SER I 676 -1  O  CYS I 675   N  CYS I 662           
SHEET    3  CC 4 VAL I 681  ASN I 685 -1  O  TRP I 684   N  ILE I 672           
SHEET    4  CC 4 LEU I 691  TYR I 695 -1  O  TYR I 695   N  VAL I 681           
SHEET    1  CD 4 VAL I 702  PHE I 707  0                                        
SHEET    2  CD 4 LEU I 715  SER I 720 -1  O  GLY I 719   N  ASN I 703           
SHEET    3  CD 4 LEU I 725  ASP I 729 -1  O  TRP I 728   N  LEU I 716           
SHEET    4  CD 4 CYS I 735  MET I 739 -1  O  ASN I 737   N  LEU I 727           
SHEET    1  CE 4 VAL I 746  CYS I 749  0                                        
SHEET    2  CE 4 LEU I 757  SER I 762 -1  O  CYS I 761   N  HIS I 748           
SHEET    3  CE 4 LYS I 768  ASP I 771 -1  O  TRP I 770   N  LEU I 758           
SHEET    4  CE 4 ASN I 776  LYS I 779 -1  O  LYS I 779   N  LEU I 769           
SHEET    1  CF 4 CYS I 804  TRP I 806  0                                        
SHEET    2  CF 4 ILE I 813  ALA I 817 -1  O  MET I 814   N  SER I 805           
SHEET    3  CF 4 LYS I 820  ASP I 825 -1  O  PHE I 822   N  VAL I 815           
SHEET    4  CF 4 GLY I 830  GLY I 833 -1  O  GLY I 830   N  ASP I 825           
SHEET    1  CG 3 LEU I 854  ALA I 858  0                                        
SHEET    2  CG 3 VAL I 864  ASN I 868 -1  O  TRP I 867   N  ALA I 855           
SHEET    3  CG 3 SER I 873  ALA I 876 -1  O  VAL I 875   N  LEU I 866           
SHEET    1  CH 3 VAL I 928  PHE I 930  0                                        
SHEET    2  CH 3 VAL I 935  VAL I 937 -1  O  MET I 936   N  VAL I 929           
SHEET    3  CH 3 ILE I 949  ASN I 950 -1  O  ILE I 949   N  VAL I 937           
SHEET    1  CI 2 LEU I 946  GLN I 947  0                                        
SHEET    2  CI 2 TYR I 958  LEU I 959 -1  O  LEU I 959   N  LEU I 946           
SHEET    1  CJ 2 CYS I 967  LEU I 969  0                                        
SHEET    2  CJ 2 ILE I 976  PHE I 978 -1  O  ALA I 977   N  CYS I 968           
SHEET    1  CK 2 ILE I 985  GLU I 986  0                                        
SHEET    2  CK 2 SER I 998  ARG I 999 -1  O  ARG I 999   N  ILE I 985           
SHEET    1  CL 4 ILE I1009  PHE I1011  0                                        
SHEET    2  CL 4 LEU I1018  SER I1020 -1  O  ILE I1019   N  GLN I1010           
SHEET    3  CL 4 ILE I1027  ASN I1031 -1  O  GLN I1028   N  SER I1020           
SHEET    4  CL 4 LYS I1036  LEU I1040 -1  O  LEU I1040   N  ILE I1027           
SHEET    1  CM 4 ASP I1049  LEU I1052  0                                        
SHEET    2  CM 4 ARG I1057  TRP I1061 -1  O  TRP I1061   N  ASP I1049           
SHEET    3  CM 4 VAL I1067  ASN I1071 -1  O  TRP I1070   N  LEU I1058           
SHEET    4  CM 4 LYS I1079  PHE I1081 -1  O  PHE I1081   N  VAL I1067           
SHEET    1  CN 4 SER I1090  ILE I1093  0                                        
SHEET    2  CN 4 SER I1101  SER I1104 -1  O  SER I1102   N  ASP I1092           
SHEET    3  CN 4 ALA I1109  TRP I1112 -1  O  TRP I1112   N  SER I1101           
SHEET    4  CN 4 HIS I1121  LEU I1123 -1  O  HIS I1121   N  ILE I1111           
SHEET    1  CO 2 CYS I1132  PHE I1135  0                                        
SHEET    2  CO 2 LEU I1142  GLY I1145 -1  O  GLY I1145   N  CYS I1132           
SHEET    1  CP 3 ASP I1182  PHE I1185  0                                        
SHEET    2  CP 3 MET I1191  ALA I1195 -1  O  ILE I1193   N  CYS I1184           
SHEET    3  CP 3 ILE I1199  ASN I1203 -1  O  LYS I1200   N  SER I1194           
SHEET    1  CQ 2 VAL I1233  VAL I1235  0                                        
SHEET    2  CQ 2 LEU I1241  ILE I1243 -1  O  TYR I1242   N  THR I1234           
SHEET    1  CR 5 VAL K 182  GLY K 188  0                                        
SHEET    2  CR 5 LEU K 239  ASP K 244  1  O  ILE K 241   N  VAL K 185           
SHEET    3  CR 5 ILE K 260  THR K 264  1  O  LEU K 261   N  LEU K 240           
SHEET    4  CR 5 TRP K 149  HIS K 153  1  N  ILE K 152   O  THR K 264           
SHEET    5  CR 5 LYS K 277  PRO K 281  1  O  TYR K 278   N  THR K 151           
SHEET    1  CS 2 VAL K 395  PRO K 396  0                                        
SHEET    2  CS 2 ARG K 434  TYR K 435 -1  O  TYR K 435   N  VAL K 395           
SHEET    1  CT 4 LEU K 609  VAL K 611  0                                        
SHEET    2  CT 4 ILE K 906  GLU K 910 -1  O  ILE K 906   N  VAL K 611           
SHEET    3  CT 4 SER K 896  SER K 901 -1  N  PHE K 897   O  TRP K 909           
SHEET    4  CT 4 VAL K 885  PHE K 890 -1  N  GLY K 887   O  SER K 900           
SHEET    1  CU 4 ALA K 621  PHE K 623  0                                        
SHEET    2  CU 4 ILE K 630  SER K 632 -1  O  ALA K 631   N  CYS K 622           
SHEET    3  CU 4 GLN K 640  LYS K 643 -1  O  PHE K 642   N  ILE K 630           
SHEET    4  CU 4 GLU K 648  GLU K 652 -1  O  LEU K 650   N  VAL K 641           
SHEET    1  CV 4 VAL K 660  PHE K 665  0                                        
SHEET    2  CV 4 PHE K 671  SER K 676 -1  O  CYS K 675   N  CYS K 662           
SHEET    3  CV 4 VAL K 681  ASN K 685 -1  O  TRP K 684   N  ILE K 672           
SHEET    4  CV 4 LEU K 691  TYR K 695 -1  O  TYR K 695   N  VAL K 681           
SHEET    1  CW 4 VAL K 702  PHE K 707  0                                        
SHEET    2  CW 4 LEU K 715  SER K 720 -1  O  GLY K 719   N  ASN K 703           
SHEET    3  CW 4 LEU K 725  ASP K 729 -1  O  TRP K 728   N  LEU K 716           
SHEET    4  CW 4 CYS K 735  MET K 739 -1  O  ASN K 737   N  LEU K 727           
SHEET    1  CX 4 VAL K 746  CYS K 749  0                                        
SHEET    2  CX 4 LEU K 757  SER K 762 -1  O  CYS K 761   N  HIS K 748           
SHEET    3  CX 4 LYS K 768  ASP K 771 -1  O  TRP K 770   N  LEU K 758           
SHEET    4  CX 4 ASN K 776  LYS K 779 -1  O  LYS K 779   N  LEU K 769           
SHEET    1  CY 4 CYS K 804  TRP K 806  0                                        
SHEET    2  CY 4 ILE K 813  ALA K 817 -1  O  MET K 814   N  SER K 805           
SHEET    3  CY 4 LYS K 820  ASP K 825 -1  O  PHE K 822   N  VAL K 815           
SHEET    4  CY 4 GLY K 830  GLY K 833 -1  O  GLY K 830   N  ASP K 825           
SHEET    1  CZ 3 LEU K 854  ALA K 858  0                                        
SHEET    2  CZ 3 VAL K 864  ASN K 868 -1  O  TRP K 867   N  ALA K 855           
SHEET    3  CZ 3 SER K 873  ALA K 876 -1  O  VAL K 875   N  LEU K 866           
SHEET    1  DA 3 VAL K 928  PHE K 930  0                                        
SHEET    2  DA 3 VAL K 935  VAL K 937 -1  O  MET K 936   N  VAL K 929           
SHEET    3  DA 3 ILE K 949  ASN K 950 -1  O  ILE K 949   N  VAL K 937           
SHEET    1  DB 2 LEU K 946  GLN K 947  0                                        
SHEET    2  DB 2 TYR K 958  LEU K 959 -1  O  LEU K 959   N  LEU K 946           
SHEET    1  DC 2 CYS K 967  LEU K 969  0                                        
SHEET    2  DC 2 ILE K 976  PHE K 978 -1  O  ALA K 977   N  CYS K 968           
SHEET    1  DD 2 ILE K 985  GLU K 986  0                                        
SHEET    2  DD 2 SER K 998  ARG K 999 -1  O  ARG K 999   N  ILE K 985           
SHEET    1  DE 4 ILE K1009  PHE K1011  0                                        
SHEET    2  DE 4 LEU K1018  SER K1020 -1  O  ILE K1019   N  GLN K1010           
SHEET    3  DE 4 ILE K1027  ASN K1031 -1  O  GLN K1028   N  SER K1020           
SHEET    4  DE 4 LYS K1036  LEU K1040 -1  O  LEU K1040   N  ILE K1027           
SHEET    1  DF 4 ASP K1049  LEU K1052  0                                        
SHEET    2  DF 4 ARG K1057  TRP K1061 -1  O  TRP K1061   N  ASP K1049           
SHEET    3  DF 4 VAL K1067  ASN K1071 -1  O  TRP K1070   N  LEU K1058           
SHEET    4  DF 4 LYS K1079  PHE K1081 -1  O  PHE K1081   N  VAL K1067           
SHEET    1  DG 4 SER K1090  ILE K1093  0                                        
SHEET    2  DG 4 SER K1101  SER K1104 -1  O  SER K1102   N  ASP K1092           
SHEET    3  DG 4 ALA K1109  TRP K1112 -1  O  TRP K1112   N  SER K1101           
SHEET    4  DG 4 HIS K1121  LEU K1123 -1  O  HIS K1121   N  ILE K1111           
SHEET    1  DH 2 CYS K1132  PHE K1135  0                                        
SHEET    2  DH 2 LEU K1142  GLY K1145 -1  O  GLY K1145   N  CYS K1132           
SHEET    1  DI 3 ASP K1182  PHE K1185  0                                        
SHEET    2  DI 3 MET K1191  ALA K1195 -1  O  ILE K1193   N  CYS K1184           
SHEET    3  DI 3 ILE K1199  ASN K1203 -1  O  LYS K1200   N  SER K1194           
SHEET    1  DJ 2 VAL K1233  VAL K1235  0                                        
SHEET    2  DJ 2 LEU K1241  ILE K1243 -1  O  TYR K1242   N  THR K1234           
SHEET    1  DK 5 VAL M 182  GLY M 188  0                                        
SHEET    2  DK 5 LEU M 239  ASP M 244  1  O  ILE M 241   N  VAL M 185           
SHEET    3  DK 5 ILE M 260  THR M 264  1  O  LEU M 261   N  LEU M 240           
SHEET    4  DK 5 TRP M 149  HIS M 153  1  N  ILE M 152   O  THR M 264           
SHEET    5  DK 5 LYS M 277  PRO M 281  1  O  TYR M 278   N  THR M 151           
SHEET    1  DL 2 VAL M 395  PRO M 396  0                                        
SHEET    2  DL 2 ARG M 434  TYR M 435 -1  O  TYR M 435   N  VAL M 395           
SHEET    1  DM 4 LEU M 609  VAL M 611  0                                        
SHEET    2  DM 4 ILE M 906  GLU M 910 -1  O  ILE M 906   N  VAL M 611           
SHEET    3  DM 4 SER M 896  SER M 901 -1  N  PHE M 897   O  TRP M 909           
SHEET    4  DM 4 VAL M 885  PHE M 890 -1  N  GLY M 887   O  SER M 900           
SHEET    1  DN 4 ALA M 621  PHE M 623  0                                        
SHEET    2  DN 4 ILE M 630  SER M 632 -1  O  ALA M 631   N  CYS M 622           
SHEET    3  DN 4 GLN M 640  LYS M 643 -1  O  PHE M 642   N  ILE M 630           
SHEET    4  DN 4 GLU M 648  GLU M 652 -1  O  LEU M 650   N  VAL M 641           
SHEET    1  DO 4 VAL M 660  PHE M 665  0                                        
SHEET    2  DO 4 PHE M 671  SER M 676 -1  O  CYS M 675   N  CYS M 662           
SHEET    3  DO 4 VAL M 681  ASN M 685 -1  O  TRP M 684   N  ILE M 672           
SHEET    4  DO 4 LEU M 691  TYR M 695 -1  O  TYR M 695   N  VAL M 681           
SHEET    1  DP 4 VAL M 702  PHE M 707  0                                        
SHEET    2  DP 4 LEU M 715  SER M 720 -1  O  GLY M 719   N  ASN M 703           
SHEET    3  DP 4 LEU M 725  ASP M 729 -1  O  TRP M 728   N  LEU M 716           
SHEET    4  DP 4 CYS M 735  MET M 739 -1  O  ASN M 737   N  LEU M 727           
SHEET    1  DQ 4 VAL M 746  CYS M 749  0                                        
SHEET    2  DQ 4 LEU M 757  SER M 762 -1  O  CYS M 761   N  HIS M 748           
SHEET    3  DQ 4 LYS M 768  ASP M 771 -1  O  TRP M 770   N  LEU M 758           
SHEET    4  DQ 4 ASN M 776  LYS M 779 -1  O  LYS M 779   N  LEU M 769           
SHEET    1  DR 4 CYS M 804  TRP M 806  0                                        
SHEET    2  DR 4 ILE M 813  ALA M 817 -1  O  MET M 814   N  SER M 805           
SHEET    3  DR 4 LYS M 820  ASP M 825 -1  O  PHE M 822   N  VAL M 815           
SHEET    4  DR 4 GLY M 830  GLY M 833 -1  O  GLY M 830   N  ASP M 825           
SHEET    1  DS 3 LEU M 854  ALA M 858  0                                        
SHEET    2  DS 3 VAL M 864  ASN M 868 -1  O  TRP M 867   N  ALA M 855           
SHEET    3  DS 3 SER M 873  ALA M 876 -1  O  VAL M 875   N  LEU M 866           
SHEET    1  DT 3 VAL M 928  PHE M 930  0                                        
SHEET    2  DT 3 VAL M 935  VAL M 937 -1  O  MET M 936   N  VAL M 929           
SHEET    3  DT 3 ILE M 949  ASN M 950 -1  O  ILE M 949   N  VAL M 937           
SHEET    1  DU 2 LEU M 946  GLN M 947  0                                        
SHEET    2  DU 2 TYR M 958  LEU M 959 -1  O  LEU M 959   N  LEU M 946           
SHEET    1  DV 2 CYS M 967  LEU M 969  0                                        
SHEET    2  DV 2 ILE M 976  PHE M 978 -1  O  ALA M 977   N  CYS M 968           
SHEET    1  DW 2 ILE M 985  GLU M 986  0                                        
SHEET    2  DW 2 SER M 998  ARG M 999 -1  O  ARG M 999   N  ILE M 985           
SHEET    1  DX 4 ILE M1009  PHE M1011  0                                        
SHEET    2  DX 4 LEU M1018  SER M1020 -1  O  ILE M1019   N  GLN M1010           
SHEET    3  DX 4 ILE M1027  ASN M1031 -1  O  GLN M1028   N  SER M1020           
SHEET    4  DX 4 LYS M1036  LEU M1040 -1  O  LEU M1040   N  ILE M1027           
SHEET    1  DY 4 ASP M1049  LEU M1052  0                                        
SHEET    2  DY 4 ARG M1057  TRP M1061 -1  O  TRP M1061   N  ASP M1049           
SHEET    3  DY 4 VAL M1067  ASN M1071 -1  O  TRP M1070   N  LEU M1058           
SHEET    4  DY 4 LYS M1079  PHE M1081 -1  O  PHE M1081   N  VAL M1067           
SHEET    1  DZ 4 SER M1090  ILE M1093  0                                        
SHEET    2  DZ 4 SER M1101  SER M1104 -1  O  SER M1102   N  ASP M1092           
SHEET    3  DZ 4 ALA M1109  TRP M1112 -1  O  TRP M1112   N  SER M1101           
SHEET    4  DZ 4 HIS M1121  LEU M1123 -1  O  HIS M1121   N  ILE M1111           
SHEET    1  EA 2 CYS M1132  PHE M1135  0                                        
SHEET    2  EA 2 LEU M1142  GLY M1145 -1  O  GLY M1145   N  CYS M1132           
SHEET    1  EB 3 ASP M1182  PHE M1185  0                                        
SHEET    2  EB 3 MET M1191  ALA M1195 -1  O  ILE M1193   N  CYS M1184           
SHEET    3  EB 3 ILE M1199  ASN M1203 -1  O  LYS M1200   N  SER M1194           
SHEET    1  EC 2 VAL M1233  VAL M1235  0                                        
SHEET    2  EC 2 LEU M1241  ILE M1243 -1  O  TYR M1242   N  THR M1234           
SSBOND   1 CYS A  633    CYS A  663                          1555   1555  2.20  
SSBOND   2 CYS A  675    CYS A  705                          1555   1555  2.02  
SSBOND   3 CYS A  704    CYS A  749                          1555   1555  1.90  
SSBOND   4 CYS A  761    CYS A  804                          1555   1555  2.05  
SSBOND   5 CYS A  803    CYS A  846                          1555   1555  2.09  
SSBOND   6 CYS C  633    CYS C  663                          1555   1555  2.20  
SSBOND   7 CYS C  675    CYS C  705                          1555   1555  2.02  
SSBOND   8 CYS C  704    CYS C  749                          1555   1555  1.89  
SSBOND   9 CYS C  761    CYS C  804                          1555   1555  2.05  
SSBOND  10 CYS C  803    CYS C  846                          1555   1555  2.09  
SSBOND  11 CYS E  633    CYS E  663                          1555   1555  2.20  
SSBOND  12 CYS E  675    CYS E  705                          1555   1555  2.02  
SSBOND  13 CYS E  704    CYS E  749                          1555   1555  1.89  
SSBOND  14 CYS E  761    CYS E  804                          1555   1555  2.05  
SSBOND  15 CYS E  803    CYS E  846                          1555   1555  2.09  
SSBOND  16 CYS G  633    CYS G  663                          1555   1555  2.20  
SSBOND  17 CYS G  675    CYS G  705                          1555   1555  2.02  
SSBOND  18 CYS G  704    CYS G  749                          1555   1555  1.89  
SSBOND  19 CYS G  761    CYS G  804                          1555   1555  2.05  
SSBOND  20 CYS G  803    CYS G  846                          1555   1555  2.09  
SSBOND  21 CYS I  633    CYS I  663                          1555   1555  2.20  
SSBOND  22 CYS I  675    CYS I  705                          1555   1555  2.02  
SSBOND  23 CYS I  704    CYS I  749                          1555   1555  1.89  
SSBOND  24 CYS I  761    CYS I  804                          1555   1555  2.05  
SSBOND  25 CYS I  803    CYS I  846                          1555   1555  2.09  
SSBOND  26 CYS K  633    CYS K  663                          1555   1555  2.20  
SSBOND  27 CYS K  675    CYS K  705                          1555   1555  2.02  
SSBOND  28 CYS K  704    CYS K  749                          1555   1555  1.90  
SSBOND  29 CYS K  761    CYS K  804                          1555   1555  2.05  
SSBOND  30 CYS K  803    CYS K  846                          1555   1555  2.10  
SSBOND  31 CYS M  633    CYS M  663                          1555   1555  2.20  
SSBOND  32 CYS M  675    CYS M  705                          1555   1555  2.02  
SSBOND  33 CYS M  704    CYS M  749                          1555   1555  1.90  
SSBOND  34 CYS M  761    CYS M  804                          1555   1555  2.05  
SSBOND  35 CYS M  803    CYS M  846                          1555   1555  2.10  
LINK         O2B DTP K1301                MG    MG K1302     1555   1555  2.17  
LINK         O2B DTP I1301                MG    MG I1302     1555   1555  2.17  
LINK         O2B DTP G1301                MG    MG G1302     1555   1555  2.17  
LINK         O2B DTP C1301                MG    MG C1302     1555   1555  2.17  
LINK         O2B DTP M1301                MG    MG M1302     1555   1555  2.17  
LINK         O2B DTP A1301                MG    MG A1302     1555   1555  2.17  
LINK         O2B DTP E1301                MG    MG E1302     1555   1555  2.17  
LINK         NE2 HIS J  18                FE   HEM J 201     1555   1555  2.37  
LINK         NE2 HIS B  18                FE   HEM B 201     1555   1555  2.37  
LINK         NE2 HIS H  18                FE   HEM H 201     1555   1555  2.37  
LINK         NE2 HIS D  18                FE   HEM D 201     1555   1555  2.37  
LINK         NE2 HIS L  18                FE   HEM L 201     1555   1555  2.37  
LINK         NE2 HIS N  18                FE   HEM N 201     1555   1555  2.37  
LINK         NE2 HIS F  18                FE   HEM F 201     1555   1555  2.37  
LINK         OG  SER C 161                MG    MG C1302     1555   1555  2.43  
LINK         OG  SER G 161                MG    MG G1302     1555   1555  2.43  
LINK         OG  SER I 161                MG    MG I1302     1555   1555  2.43  
LINK         OG  SER M 161                MG    MG M1302     1555   1555  2.43  
LINK         OG  SER A 161                MG    MG A1302     1555   1555  2.43  
LINK         OG  SER E 161                MG    MG E1302     1555   1555  2.43  
LINK         O3G DTP M1301                MG    MG M1302     1555   1555  2.43  
LINK         OG  SER K 161                MG    MG K1302     1555   1555  2.43  
LINK         O3G DTP K1301                MG    MG K1302     1555   1555  2.43  
LINK         O3G DTP I1301                MG    MG I1302     1555   1555  2.43  
LINK         O3G DTP G1301                MG    MG G1302     1555   1555  2.43  
LINK         O3G DTP C1301                MG    MG C1302     1555   1555  2.43  
LINK         O3G DTP E1301                MG    MG E1302     1555   1555  2.43  
LINK         O3G DTP A1301                MG    MG A1302     1555   1555  2.44  
LINK         SD  MET L  80                FE   HEM L 201     1555   1555  2.44  
LINK         SD  MET N  80                FE   HEM N 201     1555   1555  2.44  
LINK         SD  MET H  80                FE   HEM H 201     1555   1555  2.44  
LINK         SD  MET J  80                FE   HEM J 201     1555   1555  2.44  
LINK         SD  MET F  80                FE   HEM F 201     1555   1555  2.44  
LINK         SD  MET D  80                FE   HEM D 201     1555   1555  2.44  
LINK         SD  MET B  80                FE   HEM B 201     1555   1555  2.44  
SITE     1 AC1 13 VAL A 125  PHE A 126  VAL A 127  GLY A 159                    
SITE     2 AC1 13 LYS A 160  SER A 161  VAL A 162  ASP A 244                    
SITE     3 AC1 13 ARG A 265  PRO A 321  SER A 325  TYR A 359                    
SITE     4 AC1 13  MG A1302                                                     
SITE     1 AC2  3 SER A 161  ASP A 243  DTP A1301                               
SITE     1 AC3 22 LYS B  13  CYS B  14  CYS B  17  HIS B  18                    
SITE     2 AC3 22 THR B  28  GLY B  29  PRO B  30  LEU B  32                    
SITE     3 AC3 22 ARG B  38  THR B  40  GLY B  41  TYR B  48                    
SITE     4 AC3 22 THR B  49  ASN B  52  TRP B  59  TYR B  67                    
SITE     5 AC3 22 THR B  78  LYS B  79  MET B  80  ILE B  81                    
SITE     6 AC3 22 PHE B  82  LEU B  94                                          
SITE     1 AC4 13 VAL C 125  PHE C 126  VAL C 127  GLY C 159                    
SITE     2 AC4 13 LYS C 160  SER C 161  VAL C 162  ASP C 244                    
SITE     3 AC4 13 ARG C 265  PRO C 321  SER C 325  TYR C 359                    
SITE     4 AC4 13  MG C1302                                                     
SITE     1 AC5  3 SER C 161  ASP C 243  DTP C1301                               
SITE     1 AC6 22 LYS D  13  CYS D  14  CYS D  17  HIS D  18                    
SITE     2 AC6 22 THR D  28  GLY D  29  PRO D  30  LEU D  32                    
SITE     3 AC6 22 ARG D  38  THR D  40  GLY D  41  TYR D  48                    
SITE     4 AC6 22 THR D  49  ASN D  52  TRP D  59  TYR D  67                    
SITE     5 AC6 22 THR D  78  LYS D  79  MET D  80  ILE D  81                    
SITE     6 AC6 22 PHE D  82  LEU D  94                                          
SITE     1 AC7 13 VAL E 125  PHE E 126  VAL E 127  GLY E 159                    
SITE     2 AC7 13 LYS E 160  SER E 161  VAL E 162  ASP E 244                    
SITE     3 AC7 13 ARG E 265  PRO E 321  SER E 325  TYR E 359                    
SITE     4 AC7 13  MG E1302                                                     
SITE     1 AC8  3 SER E 161  ASP E 243  DTP E1301                               
SITE     1 AC9 22 LYS F  13  CYS F  14  CYS F  17  HIS F  18                    
SITE     2 AC9 22 THR F  28  GLY F  29  PRO F  30  LEU F  32                    
SITE     3 AC9 22 ARG F  38  THR F  40  GLY F  41  TYR F  48                    
SITE     4 AC9 22 THR F  49  ASN F  52  TRP F  59  TYR F  67                    
SITE     5 AC9 22 THR F  78  LYS F  79  MET F  80  ILE F  81                    
SITE     6 AC9 22 PHE F  82  LEU F  94                                          
SITE     1 BC1 13 VAL G 125  PHE G 126  VAL G 127  GLY G 159                    
SITE     2 BC1 13 LYS G 160  SER G 161  VAL G 162  ASP G 244                    
SITE     3 BC1 13 ARG G 265  PRO G 321  SER G 325  TYR G 359                    
SITE     4 BC1 13  MG G1302                                                     
SITE     1 BC2  3 SER G 161  ASP G 243  DTP G1301                               
SITE     1 BC3 22 LYS H  13  CYS H  14  CYS H  17  HIS H  18                    
SITE     2 BC3 22 THR H  28  GLY H  29  PRO H  30  LEU H  32                    
SITE     3 BC3 22 ARG H  38  THR H  40  GLY H  41  TYR H  48                    
SITE     4 BC3 22 THR H  49  ASN H  52  TRP H  59  TYR H  67                    
SITE     5 BC3 22 THR H  78  LYS H  79  MET H  80  ILE H  81                    
SITE     6 BC3 22 PHE H  82  LEU H  94                                          
SITE     1 BC4 13 VAL I 125  PHE I 126  VAL I 127  GLY I 159                    
SITE     2 BC4 13 LYS I 160  SER I 161  VAL I 162  ASP I 244                    
SITE     3 BC4 13 ARG I 265  PRO I 321  SER I 325  TYR I 359                    
SITE     4 BC4 13  MG I1302                                                     
SITE     1 BC5  3 SER I 161  ASP I 243  DTP I1301                               
SITE     1 BC6 22 LYS J  13  CYS J  14  CYS J  17  HIS J  18                    
SITE     2 BC6 22 THR J  28  GLY J  29  PRO J  30  LEU J  32                    
SITE     3 BC6 22 ARG J  38  THR J  40  GLY J  41  TYR J  48                    
SITE     4 BC6 22 THR J  49  ASN J  52  TRP J  59  TYR J  67                    
SITE     5 BC6 22 THR J  78  LYS J  79  MET J  80  ILE J  81                    
SITE     6 BC6 22 PHE J  82  LEU J  94                                          
SITE     1 BC7 13 VAL K 125  PHE K 126  VAL K 127  GLY K 159                    
SITE     2 BC7 13 LYS K 160  SER K 161  VAL K 162  ASP K 244                    
SITE     3 BC7 13 ARG K 265  PRO K 321  SER K 325  TYR K 359                    
SITE     4 BC7 13  MG K1302                                                     
SITE     1 BC8  3 SER K 161  ASP K 243  DTP K1301                               
SITE     1 BC9 22 LYS L  13  CYS L  14  CYS L  17  HIS L  18                    
SITE     2 BC9 22 THR L  28  GLY L  29  PRO L  30  LEU L  32                    
SITE     3 BC9 22 ARG L  38  THR L  40  GLY L  41  TYR L  48                    
SITE     4 BC9 22 THR L  49  ASN L  52  TRP L  59  TYR L  67                    
SITE     5 BC9 22 THR L  78  LYS L  79  MET L  80  ILE L  81                    
SITE     6 BC9 22 PHE L  82  LEU L  94                                          
SITE     1 CC1 13 VAL M 125  PHE M 126  VAL M 127  GLY M 159                    
SITE     2 CC1 13 LYS M 160  SER M 161  VAL M 162  ASP M 244                    
SITE     3 CC1 13 ARG M 265  PRO M 321  SER M 325  TYR M 359                    
SITE     4 CC1 13  MG M1302                                                     
SITE     1 CC2  3 SER M 161  ASP M 243  DTP M1301                               
SITE     1 CC3 22 LYS N  13  CYS N  14  CYS N  17  HIS N  18                    
SITE     2 CC3 22 THR N  28  GLY N  29  PRO N  30  LEU N  32                    
SITE     3 CC3 22 ARG N  38  THR N  40  GLY N  41  TYR N  48                    
SITE     4 CC3 22 THR N  49  ASN N  52  TRP N  59  TYR N  67                    
SITE     5 CC3 22 THR N  78  LYS N  79  MET N  80  ILE N  81                    
SITE     6 CC3 22 PHE N  82  LEU N  94                                          
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system