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Database: PDB
Entry: 3JSK
LinkDB: 3JSK
Original site: 3JSK 
HEADER    BIOSYNTHETIC PROTEIN                    10-SEP-09   3JSK              
TITLE     THIAZOLE SYNTHASE FROM NEUROSPORA CRASSA                              
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: CYPBP37 PROTEIN;                                           
COMPND   3 CHAIN: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P;               
COMPND   4 SYNONYM: NEUROSPORA CRASSA THIAZOLE SYNTHASE;                        
COMPND   5 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: NEUROSPORA CRASSA;                              
SOURCE   3 ORGANISM_TAXID: 5141;                                                
SOURCE   4 GENE: NCU06110, NCU06110.1;                                          
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21;                                      
SOURCE   8 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE   9 EXPRESSION_SYSTEM_PLASMID: PET19B                                    
KEYWDS    OCTAMERIC THIAZOLE SYNTHASE, BIOSYNTHETIC PROTEIN                     
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    Y.N.KANG,S.BALE,S.E.EALICK                                            
REVDAT   2   01-NOV-17 3JSK    1       REMARK                                   
REVDAT   1   29-SEP-10 3JSK    0                                                
JRNL        AUTH   Y.N.KANG,S.BALE,T.P.BEGLEY,S.E.EALICK                        
JRNL        TITL   CRYSTAL STRUCTURE OF THIAZOLE SYNTHASE THI4 FROM NEUROSPORA  
JRNL        TITL 2 CRASSA                                                       
JRNL        REF    TO BE PUBLISHED                                              
JRNL        REFN                                                                
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.70 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : CNS 1.2                                              
REMARK   3   AUTHORS     : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE-              
REMARK   3               : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES,PANNU,              
REMARK   3               : READ,RICE,SIMONSON,WARREN                            
REMARK   3                                                                      
REMARK   3  REFINEMENT TARGET : ENGH & HUBER                                    
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.70                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 49.98                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : 0.000                          
REMARK   3   DATA CUTOFF HIGH         (ABS(F)) : 37593.000                      
REMARK   3   DATA CUTOFF LOW          (ABS(F)) : 0.0000                         
REMARK   3   COMPLETENESS (WORKING+TEST)   (%) : 92.2                           
REMARK   3   NUMBER OF REFLECTIONS             : 157169                         
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE            (WORKING SET) : 0.202                           
REMARK   3   FREE R VALUE                     : 0.246                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 10.000                          
REMARK   3   FREE R VALUE TEST SET COUNT      : 15651                           
REMARK   3   ESTIMATED ERROR OF FREE R VALUE  : 0.002                           
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 6                            
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 2.70                         
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 2.87                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 83.40                        
REMARK   3   REFLECTIONS IN BIN    (WORKING SET) : 21155                        
REMARK   3   BIN R VALUE           (WORKING SET) : 0.2690                       
REMARK   3   BIN FREE R VALUE                    : 0.3110                       
REMARK   3   BIN FREE R VALUE TEST SET SIZE  (%) : 10.20                        
REMARK   3   BIN FREE R VALUE TEST SET COUNT     : 2395                         
REMARK   3   ESTIMATED ERROR OF BIN FREE R VALUE : 0.006                        
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 35038                                   
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 624                                     
REMARK   3   SOLVENT ATOMS            : 391                                     
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 17.60                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 35.53                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 7.47000                                              
REMARK   3    B22 (A**2) : -7.42000                                             
REMARK   3    B33 (A**2) : -0.06000                                             
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 4.83000                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  ESTIMATED COORDINATE ERROR.                                         
REMARK   3   ESD FROM LUZZATI PLOT        (A) : 0.30                            
REMARK   3   ESD FROM SIGMAA              (A) : 0.36                            
REMARK   3   LOW RESOLUTION CUTOFF        (A) : 5.00                            
REMARK   3                                                                      
REMARK   3  CROSS-VALIDATED ESTIMATED COORDINATE ERROR.                         
REMARK   3   ESD FROM C-V LUZZATI PLOT    (A) : 0.37                            
REMARK   3   ESD FROM C-V SIGMAA          (A) : 0.44                            
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES.                                   
REMARK   3   BOND LENGTHS                 (A) : 0.007                           
REMARK   3   BOND ANGLES            (DEGREES) : 1.400                           
REMARK   3   DIHEDRAL ANGLES        (DEGREES) : 21.90                           
REMARK   3   IMPROPER ANGLES        (DEGREES) : 0.840                           
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL MODEL : RESTRAINED                                
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.    RMS    SIGMA                
REMARK   3   MAIN-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   MAIN-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN BOND              (A**2) : NULL  ; NULL                 
REMARK   3   SIDE-CHAIN ANGLE             (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELING.                                              
REMARK   3   METHOD USED : FLAT MODEL                                           
REMARK   3   KSOL        : 0.35                                                 
REMARK   3   BSOL        : 25.60                                                
REMARK   3                                                                      
REMARK   3  NCS MODEL : NULL                                                    
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS.                         RMS   SIGMA/WEIGHT          
REMARK   3   GROUP  1  POSITIONAL            (A) : NULL  ; NULL                 
REMARK   3   GROUP  1  B-FACTOR           (A**2) : NULL  ; NULL                 
REMARK   3                                                                      
REMARK   3  PARAMETER FILE  1  : PROTEIN_REP.PARAM                              
REMARK   3  PARAMETER FILE  2  : WATER_REP.PARAM                                
REMARK   3  PARAMETER FILE  3  : AHZ.PARAM                                      
REMARK   3  PARAMETER FILE  4  : DHA.PARAM                                      
REMARK   3  PARAMETER FILE  5  : NULL                                           
REMARK   3  PARAMETER FILE  6  : NULL                                           
REMARK   3  TOPOLOGY FILE  1   : PROTEIN_REP.TOP                                
REMARK   3  TOPOLOGY FILE  2   : AHZ.TOP                                        
REMARK   3  TOPOLOGY FILE  3   : DHA.TOP                                        
REMARK   3  TOPOLOGY FILE  4   : &_1_TOPOLOGY_INFILE_4                          
REMARK   3  TOPOLOGY FILE  5   : &_1_TOPOLOGY_INFILE_5                          
REMARK   3  TOPOLOGY FILE  6   : NULL                                           
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: BULK SOLVENT MODEL USED                   
REMARK   4                                                                      
REMARK   4 3JSK COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 17-SEP-09.                  
REMARK 100 THE DEPOSITION ID IS D_1000055105.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 01-MAR-07                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 7.0                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 24-ID-E                            
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9791                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315                   
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : DENZO, HKL-2000                    
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK, HKL-2000                
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 157169                             
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.700                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 97.7                               
REMARK 200  DATA REDUNDANCY                : 3.500                              
REMARK 200  R MERGE                    (I) : 0.13100                            
REMARK 200  R SYM                      (I) : 0.13100                            
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 5.3000                             
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.70                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.80                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 96.9                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.20                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.37700                            
REMARK 200  R SYM FOR SHELL            (I) : 0.37700                            
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 2.200                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: CNS                                                   
REMARK 200 STARTING MODEL: PDB ENTRY 2GJC                                       
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 53.96                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.67                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 200 MM SODIUM THIOCYANATE, 20%           
REMARK 280  PEG3350, 6% ETHYLENE GLYCOL, PH 7.0, VAPOR DIFFUSION, HANGING       
REMARK 280  DROP, TEMPERATURE 291K                                              
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 2 1                          
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y,-Z                                                 
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTAMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: OCTAMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 67660 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 60860 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -495.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H                
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTAMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: OCTAMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 67450 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 60640 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -495.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: I, J, K, L, M, N, O, P                
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     SER A     2                                                      
REMARK 465     PRO A     3                                                      
REMARK 465     SER A     4                                                      
REMARK 465     VAL A     5                                                      
REMARK 465     LEU A     6                                                      
REMARK 465     GLU A     7                                                      
REMARK 465     PRO A     8                                                      
REMARK 465     GLN A     9                                                      
REMARK 465     SER A    10                                                      
REMARK 465     VAL A    11                                                      
REMARK 465     PRO A    12                                                      
REMARK 465     THR A    13                                                      
REMARK 465     LEU A    14                                                      
REMARK 465     VAL A    15                                                      
REMARK 465     ASN A    16                                                      
REMARK 465     VAL A    17                                                      
REMARK 465     GLY A    18                                                      
REMARK 465     LEU A    19                                                      
REMARK 465     LYS A    20                                                      
REMARK 465     ALA A    21                                                      
REMARK 465     VAL A    22                                                      
REMARK 465     GLY A    23                                                      
REMARK 465     ARG A    24                                                      
REMARK 465     ASN A    25                                                      
REMARK 465     ASP A    26                                                      
REMARK 465     ALA A    27                                                      
REMARK 465     PRO A    28                                                      
REMARK 465     VAL A    29                                                      
REMARK 465     GLU A    30                                                      
REMARK 465     ARG A    31                                                      
REMARK 465     ASP A    32                                                      
REMARK 465     ALA A    33                                                      
REMARK 465     ARG A    34                                                      
REMARK 465     HIS A   193                                                      
REMARK 465     ALA A   194                                                      
REMARK 465     GLU A   195                                                      
REMARK 465     SER A   196                                                      
REMARK 465     SER A   197                                                      
REMARK 465     SER A   198                                                      
REMARK 465     SER A   199                                                      
REMARK 465     SER A   200                                                      
REMARK 465     ASP A   201                                                      
REMARK 465     ASP A   202                                                      
REMARK 465     GLY A   203                                                      
REMARK 465     GLU A   204                                                      
REMARK 465     ALA A   205                                                      
REMARK 465     GLU A   206                                                      
REMARK 465     ASP A   207                                                      
REMARK 465     GLU A   208                                                      
REMARK 465     LYS A   343                                                      
REMARK 465     CYS A   344                                                      
REMARK 465     MET B     1                                                      
REMARK 465     SER B     2                                                      
REMARK 465     PRO B     3                                                      
REMARK 465     SER B     4                                                      
REMARK 465     VAL B     5                                                      
REMARK 465     LEU B     6                                                      
REMARK 465     GLU B     7                                                      
REMARK 465     PRO B     8                                                      
REMARK 465     GLN B     9                                                      
REMARK 465     SER B    10                                                      
REMARK 465     VAL B    11                                                      
REMARK 465     PRO B    12                                                      
REMARK 465     THR B    13                                                      
REMARK 465     LEU B    14                                                      
REMARK 465     VAL B    15                                                      
REMARK 465     ASN B    16                                                      
REMARK 465     VAL B    17                                                      
REMARK 465     GLY B    18                                                      
REMARK 465     LEU B    19                                                      
REMARK 465     LYS B    20                                                      
REMARK 465     ALA B    21                                                      
REMARK 465     VAL B    22                                                      
REMARK 465     GLY B    23                                                      
REMARK 465     ARG B    24                                                      
REMARK 465     ASN B    25                                                      
REMARK 465     ASP B    26                                                      
REMARK 465     ALA B    27                                                      
REMARK 465     PRO B    28                                                      
REMARK 465     VAL B    29                                                      
REMARK 465     GLU B    30                                                      
REMARK 465     ARG B    31                                                      
REMARK 465     ASP B    32                                                      
REMARK 465     ALA B    33                                                      
REMARK 465     ARG B    34                                                      
REMARK 465     HIS B   193                                                      
REMARK 465     ALA B   194                                                      
REMARK 465     GLU B   195                                                      
REMARK 465     SER B   196                                                      
REMARK 465     SER B   197                                                      
REMARK 465     SER B   198                                                      
REMARK 465     SER B   199                                                      
REMARK 465     SER B   200                                                      
REMARK 465     ASP B   201                                                      
REMARK 465     ASP B   202                                                      
REMARK 465     GLY B   203                                                      
REMARK 465     GLU B   204                                                      
REMARK 465     ALA B   205                                                      
REMARK 465     GLU B   206                                                      
REMARK 465     ASP B   207                                                      
REMARK 465     GLU B   208                                                      
REMARK 465     ALA B   209                                                      
REMARK 465     LYS B   343                                                      
REMARK 465     CYS B   344                                                      
REMARK 465     MET C     1                                                      
REMARK 465     SER C     2                                                      
REMARK 465     PRO C     3                                                      
REMARK 465     SER C     4                                                      
REMARK 465     VAL C     5                                                      
REMARK 465     LEU C     6                                                      
REMARK 465     GLU C     7                                                      
REMARK 465     PRO C     8                                                      
REMARK 465     GLN C     9                                                      
REMARK 465     SER C    10                                                      
REMARK 465     VAL C    11                                                      
REMARK 465     PRO C    12                                                      
REMARK 465     THR C    13                                                      
REMARK 465     LEU C    14                                                      
REMARK 465     VAL C    15                                                      
REMARK 465     ASN C    16                                                      
REMARK 465     VAL C    17                                                      
REMARK 465     GLY C    18                                                      
REMARK 465     LEU C    19                                                      
REMARK 465     LYS C    20                                                      
REMARK 465     ALA C    21                                                      
REMARK 465     VAL C    22                                                      
REMARK 465     GLY C    23                                                      
REMARK 465     ARG C    24                                                      
REMARK 465     ASN C    25                                                      
REMARK 465     ASP C    26                                                      
REMARK 465     ALA C    27                                                      
REMARK 465     PRO C    28                                                      
REMARK 465     VAL C    29                                                      
REMARK 465     GLU C    30                                                      
REMARK 465     ARG C    31                                                      
REMARK 465     ASP C    32                                                      
REMARK 465     ALA C    33                                                      
REMARK 465     ARG C    34                                                      
REMARK 465     HIS C   193                                                      
REMARK 465     ALA C   194                                                      
REMARK 465     GLU C   195                                                      
REMARK 465     SER C   196                                                      
REMARK 465     SER C   197                                                      
REMARK 465     SER C   198                                                      
REMARK 465     SER C   199                                                      
REMARK 465     SER C   200                                                      
REMARK 465     ASP C   201                                                      
REMARK 465     ASP C   202                                                      
REMARK 465     GLY C   203                                                      
REMARK 465     GLU C   204                                                      
REMARK 465     ALA C   205                                                      
REMARK 465     GLU C   206                                                      
REMARK 465     ASP C   207                                                      
REMARK 465     GLU C   208                                                      
REMARK 465     LYS C   343                                                      
REMARK 465     CYS C   344                                                      
REMARK 465     MET D     1                                                      
REMARK 465     SER D     2                                                      
REMARK 465     PRO D     3                                                      
REMARK 465     SER D     4                                                      
REMARK 465     VAL D     5                                                      
REMARK 465     LEU D     6                                                      
REMARK 465     GLU D     7                                                      
REMARK 465     PRO D     8                                                      
REMARK 465     GLN D     9                                                      
REMARK 465     SER D    10                                                      
REMARK 465     VAL D    11                                                      
REMARK 465     PRO D    12                                                      
REMARK 465     THR D    13                                                      
REMARK 465     LEU D    14                                                      
REMARK 465     VAL D    15                                                      
REMARK 465     ASN D    16                                                      
REMARK 465     VAL D    17                                                      
REMARK 465     GLY D    18                                                      
REMARK 465     LEU D    19                                                      
REMARK 465     LYS D    20                                                      
REMARK 465     ALA D    21                                                      
REMARK 465     VAL D    22                                                      
REMARK 465     GLY D    23                                                      
REMARK 465     ARG D    24                                                      
REMARK 465     ASN D    25                                                      
REMARK 465     ASP D    26                                                      
REMARK 465     ALA D    27                                                      
REMARK 465     PRO D    28                                                      
REMARK 465     VAL D    29                                                      
REMARK 465     GLU D    30                                                      
REMARK 465     ARG D    31                                                      
REMARK 465     ASP D    32                                                      
REMARK 465     ALA D    33                                                      
REMARK 465     ARG D    34                                                      
REMARK 465     HIS D   193                                                      
REMARK 465     ALA D   194                                                      
REMARK 465     GLU D   195                                                      
REMARK 465     SER D   196                                                      
REMARK 465     SER D   197                                                      
REMARK 465     SER D   198                                                      
REMARK 465     SER D   199                                                      
REMARK 465     SER D   200                                                      
REMARK 465     ASP D   201                                                      
REMARK 465     ASP D   202                                                      
REMARK 465     GLY D   203                                                      
REMARK 465     GLU D   204                                                      
REMARK 465     ALA D   205                                                      
REMARK 465     GLU D   206                                                      
REMARK 465     ASP D   207                                                      
REMARK 465     GLU D   208                                                      
REMARK 465     LYS D   343                                                      
REMARK 465     CYS D   344                                                      
REMARK 465     MET E     1                                                      
REMARK 465     SER E     2                                                      
REMARK 465     PRO E     3                                                      
REMARK 465     SER E     4                                                      
REMARK 465     VAL E     5                                                      
REMARK 465     LEU E     6                                                      
REMARK 465     GLU E     7                                                      
REMARK 465     PRO E     8                                                      
REMARK 465     GLN E     9                                                      
REMARK 465     SER E    10                                                      
REMARK 465     VAL E    11                                                      
REMARK 465     PRO E    12                                                      
REMARK 465     THR E    13                                                      
REMARK 465     LEU E    14                                                      
REMARK 465     VAL E    15                                                      
REMARK 465     ASN E    16                                                      
REMARK 465     VAL E    17                                                      
REMARK 465     GLY E    18                                                      
REMARK 465     LEU E    19                                                      
REMARK 465     LYS E    20                                                      
REMARK 465     ALA E    21                                                      
REMARK 465     VAL E    22                                                      
REMARK 465     GLY E    23                                                      
REMARK 465     ARG E    24                                                      
REMARK 465     ASN E    25                                                      
REMARK 465     ASP E    26                                                      
REMARK 465     ALA E    27                                                      
REMARK 465     PRO E    28                                                      
REMARK 465     VAL E    29                                                      
REMARK 465     GLU E    30                                                      
REMARK 465     ARG E    31                                                      
REMARK 465     ASP E    32                                                      
REMARK 465     ALA E    33                                                      
REMARK 465     ARG E    34                                                      
REMARK 465     HIS E   193                                                      
REMARK 465     ALA E   194                                                      
REMARK 465     GLU E   195                                                      
REMARK 465     SER E   196                                                      
REMARK 465     SER E   197                                                      
REMARK 465     SER E   198                                                      
REMARK 465     SER E   199                                                      
REMARK 465     SER E   200                                                      
REMARK 465     ASP E   201                                                      
REMARK 465     ASP E   202                                                      
REMARK 465     GLY E   203                                                      
REMARK 465     GLU E   204                                                      
REMARK 465     ALA E   205                                                      
REMARK 465     GLU E   206                                                      
REMARK 465     ASP E   207                                                      
REMARK 465     GLU E   208                                                      
REMARK 465     ALA E   209                                                      
REMARK 465     LYS E   343                                                      
REMARK 465     CYS E   344                                                      
REMARK 465     MET F     1                                                      
REMARK 465     SER F     2                                                      
REMARK 465     PRO F     3                                                      
REMARK 465     SER F     4                                                      
REMARK 465     VAL F     5                                                      
REMARK 465     LEU F     6                                                      
REMARK 465     GLU F     7                                                      
REMARK 465     PRO F     8                                                      
REMARK 465     GLN F     9                                                      
REMARK 465     SER F    10                                                      
REMARK 465     VAL F    11                                                      
REMARK 465     PRO F    12                                                      
REMARK 465     THR F    13                                                      
REMARK 465     LEU F    14                                                      
REMARK 465     VAL F    15                                                      
REMARK 465     ASN F    16                                                      
REMARK 465     VAL F    17                                                      
REMARK 465     GLY F    18                                                      
REMARK 465     LEU F    19                                                      
REMARK 465     LYS F    20                                                      
REMARK 465     ALA F    21                                                      
REMARK 465     VAL F    22                                                      
REMARK 465     GLY F    23                                                      
REMARK 465     ARG F    24                                                      
REMARK 465     ASN F    25                                                      
REMARK 465     ASP F    26                                                      
REMARK 465     ALA F    27                                                      
REMARK 465     PRO F    28                                                      
REMARK 465     VAL F    29                                                      
REMARK 465     GLU F    30                                                      
REMARK 465     ARG F    31                                                      
REMARK 465     ASP F    32                                                      
REMARK 465     ALA F    33                                                      
REMARK 465     ARG F    34                                                      
REMARK 465     HIS F   193                                                      
REMARK 465     ALA F   194                                                      
REMARK 465     GLU F   195                                                      
REMARK 465     SER F   196                                                      
REMARK 465     SER F   197                                                      
REMARK 465     SER F   198                                                      
REMARK 465     SER F   199                                                      
REMARK 465     SER F   200                                                      
REMARK 465     ASP F   201                                                      
REMARK 465     ASP F   202                                                      
REMARK 465     GLY F   203                                                      
REMARK 465     GLU F   204                                                      
REMARK 465     ALA F   205                                                      
REMARK 465     GLU F   206                                                      
REMARK 465     ASP F   207                                                      
REMARK 465     GLU F   208                                                      
REMARK 465     LYS F   343                                                      
REMARK 465     CYS F   344                                                      
REMARK 465     MET G     1                                                      
REMARK 465     SER G     2                                                      
REMARK 465     PRO G     3                                                      
REMARK 465     SER G     4                                                      
REMARK 465     VAL G     5                                                      
REMARK 465     LEU G     6                                                      
REMARK 465     GLU G     7                                                      
REMARK 465     PRO G     8                                                      
REMARK 465     GLN G     9                                                      
REMARK 465     SER G    10                                                      
REMARK 465     VAL G    11                                                      
REMARK 465     PRO G    12                                                      
REMARK 465     THR G    13                                                      
REMARK 465     LEU G    14                                                      
REMARK 465     VAL G    15                                                      
REMARK 465     ASN G    16                                                      
REMARK 465     VAL G    17                                                      
REMARK 465     GLY G    18                                                      
REMARK 465     LEU G    19                                                      
REMARK 465     LYS G    20                                                      
REMARK 465     ALA G    21                                                      
REMARK 465     VAL G    22                                                      
REMARK 465     GLY G    23                                                      
REMARK 465     ARG G    24                                                      
REMARK 465     ASN G    25                                                      
REMARK 465     ASP G    26                                                      
REMARK 465     ALA G    27                                                      
REMARK 465     PRO G    28                                                      
REMARK 465     VAL G    29                                                      
REMARK 465     GLU G    30                                                      
REMARK 465     ARG G    31                                                      
REMARK 465     ASP G    32                                                      
REMARK 465     ALA G    33                                                      
REMARK 465     ARG G    34                                                      
REMARK 465     HIS G   193                                                      
REMARK 465     ALA G   194                                                      
REMARK 465     GLU G   195                                                      
REMARK 465     SER G   196                                                      
REMARK 465     SER G   197                                                      
REMARK 465     SER G   198                                                      
REMARK 465     SER G   199                                                      
REMARK 465     SER G   200                                                      
REMARK 465     ASP G   201                                                      
REMARK 465     ASP G   202                                                      
REMARK 465     GLY G   203                                                      
REMARK 465     GLU G   204                                                      
REMARK 465     ALA G   205                                                      
REMARK 465     GLU G   206                                                      
REMARK 465     ASP G   207                                                      
REMARK 465     GLU G   208                                                      
REMARK 465     ALA G   209                                                      
REMARK 465     LYS G   343                                                      
REMARK 465     CYS G   344                                                      
REMARK 465     MET H     1                                                      
REMARK 465     SER H     2                                                      
REMARK 465     PRO H     3                                                      
REMARK 465     SER H     4                                                      
REMARK 465     VAL H     5                                                      
REMARK 465     LEU H     6                                                      
REMARK 465     GLU H     7                                                      
REMARK 465     PRO H     8                                                      
REMARK 465     GLN H     9                                                      
REMARK 465     SER H    10                                                      
REMARK 465     VAL H    11                                                      
REMARK 465     PRO H    12                                                      
REMARK 465     THR H    13                                                      
REMARK 465     LEU H    14                                                      
REMARK 465     VAL H    15                                                      
REMARK 465     ASN H    16                                                      
REMARK 465     VAL H    17                                                      
REMARK 465     GLY H    18                                                      
REMARK 465     LEU H    19                                                      
REMARK 465     LYS H    20                                                      
REMARK 465     ALA H    21                                                      
REMARK 465     VAL H    22                                                      
REMARK 465     GLY H    23                                                      
REMARK 465     ARG H    24                                                      
REMARK 465     ASN H    25                                                      
REMARK 465     ASP H    26                                                      
REMARK 465     ALA H    27                                                      
REMARK 465     PRO H    28                                                      
REMARK 465     VAL H    29                                                      
REMARK 465     GLU H    30                                                      
REMARK 465     ARG H    31                                                      
REMARK 465     ASP H    32                                                      
REMARK 465     ALA H    33                                                      
REMARK 465     ARG H    34                                                      
REMARK 465     HIS H   193                                                      
REMARK 465     ALA H   194                                                      
REMARK 465     GLU H   195                                                      
REMARK 465     SER H   196                                                      
REMARK 465     SER H   197                                                      
REMARK 465     SER H   198                                                      
REMARK 465     SER H   199                                                      
REMARK 465     SER H   200                                                      
REMARK 465     ASP H   201                                                      
REMARK 465     ASP H   202                                                      
REMARK 465     GLY H   203                                                      
REMARK 465     GLU H   204                                                      
REMARK 465     ALA H   205                                                      
REMARK 465     GLU H   206                                                      
REMARK 465     ASP H   207                                                      
REMARK 465     GLU H   208                                                      
REMARK 465     ALA H   209                                                      
REMARK 465     LYS H   343                                                      
REMARK 465     CYS H   344                                                      
REMARK 465     MET I     1                                                      
REMARK 465     SER I     2                                                      
REMARK 465     PRO I     3                                                      
REMARK 465     SER I     4                                                      
REMARK 465     VAL I     5                                                      
REMARK 465     LEU I     6                                                      
REMARK 465     GLU I     7                                                      
REMARK 465     PRO I     8                                                      
REMARK 465     GLN I     9                                                      
REMARK 465     SER I    10                                                      
REMARK 465     VAL I    11                                                      
REMARK 465     PRO I    12                                                      
REMARK 465     THR I    13                                                      
REMARK 465     LEU I    14                                                      
REMARK 465     VAL I    15                                                      
REMARK 465     ASN I    16                                                      
REMARK 465     VAL I    17                                                      
REMARK 465     GLY I    18                                                      
REMARK 465     LEU I    19                                                      
REMARK 465     LYS I    20                                                      
REMARK 465     ALA I    21                                                      
REMARK 465     VAL I    22                                                      
REMARK 465     GLY I    23                                                      
REMARK 465     ARG I    24                                                      
REMARK 465     ASN I    25                                                      
REMARK 465     ASP I    26                                                      
REMARK 465     ALA I    27                                                      
REMARK 465     PRO I    28                                                      
REMARK 465     VAL I    29                                                      
REMARK 465     GLU I    30                                                      
REMARK 465     ARG I    31                                                      
REMARK 465     ASP I    32                                                      
REMARK 465     ALA I    33                                                      
REMARK 465     ARG I    34                                                      
REMARK 465     HIS I   193                                                      
REMARK 465     ALA I   194                                                      
REMARK 465     GLU I   195                                                      
REMARK 465     SER I   196                                                      
REMARK 465     SER I   197                                                      
REMARK 465     SER I   198                                                      
REMARK 465     SER I   199                                                      
REMARK 465     SER I   200                                                      
REMARK 465     ASP I   201                                                      
REMARK 465     ASP I   202                                                      
REMARK 465     GLY I   203                                                      
REMARK 465     GLU I   204                                                      
REMARK 465     ALA I   205                                                      
REMARK 465     GLU I   206                                                      
REMARK 465     ASP I   207                                                      
REMARK 465     GLU I   208                                                      
REMARK 465     ALA I   209                                                      
REMARK 465     LYS I   343                                                      
REMARK 465     CYS I   344                                                      
REMARK 465     MET J     1                                                      
REMARK 465     SER J     2                                                      
REMARK 465     PRO J     3                                                      
REMARK 465     SER J     4                                                      
REMARK 465     VAL J     5                                                      
REMARK 465     LEU J     6                                                      
REMARK 465     GLU J     7                                                      
REMARK 465     PRO J     8                                                      
REMARK 465     GLN J     9                                                      
REMARK 465     SER J    10                                                      
REMARK 465     VAL J    11                                                      
REMARK 465     PRO J    12                                                      
REMARK 465     THR J    13                                                      
REMARK 465     LEU J    14                                                      
REMARK 465     VAL J    15                                                      
REMARK 465     ASN J    16                                                      
REMARK 465     VAL J    17                                                      
REMARK 465     GLY J    18                                                      
REMARK 465     LEU J    19                                                      
REMARK 465     LYS J    20                                                      
REMARK 465     ALA J    21                                                      
REMARK 465     VAL J    22                                                      
REMARK 465     GLY J    23                                                      
REMARK 465     ARG J    24                                                      
REMARK 465     ASN J    25                                                      
REMARK 465     ASP J    26                                                      
REMARK 465     ALA J    27                                                      
REMARK 465     PRO J    28                                                      
REMARK 465     VAL J    29                                                      
REMARK 465     GLU J    30                                                      
REMARK 465     ARG J    31                                                      
REMARK 465     ASP J    32                                                      
REMARK 465     ALA J    33                                                      
REMARK 465     ARG J    34                                                      
REMARK 465     HIS J   193                                                      
REMARK 465     ALA J   194                                                      
REMARK 465     GLU J   195                                                      
REMARK 465     SER J   196                                                      
REMARK 465     SER J   197                                                      
REMARK 465     SER J   198                                                      
REMARK 465     SER J   199                                                      
REMARK 465     SER J   200                                                      
REMARK 465     ASP J   201                                                      
REMARK 465     ASP J   202                                                      
REMARK 465     GLY J   203                                                      
REMARK 465     GLU J   204                                                      
REMARK 465     ALA J   205                                                      
REMARK 465     GLU J   206                                                      
REMARK 465     ASP J   207                                                      
REMARK 465     GLU J   208                                                      
REMARK 465     ALA J   209                                                      
REMARK 465     LYS J   343                                                      
REMARK 465     CYS J   344                                                      
REMARK 465     MET K     1                                                      
REMARK 465     SER K     2                                                      
REMARK 465     PRO K     3                                                      
REMARK 465     SER K     4                                                      
REMARK 465     VAL K     5                                                      
REMARK 465     LEU K     6                                                      
REMARK 465     GLU K     7                                                      
REMARK 465     PRO K     8                                                      
REMARK 465     GLN K     9                                                      
REMARK 465     SER K    10                                                      
REMARK 465     VAL K    11                                                      
REMARK 465     PRO K    12                                                      
REMARK 465     THR K    13                                                      
REMARK 465     LEU K    14                                                      
REMARK 465     VAL K    15                                                      
REMARK 465     ASN K    16                                                      
REMARK 465     VAL K    17                                                      
REMARK 465     GLY K    18                                                      
REMARK 465     LEU K    19                                                      
REMARK 465     LYS K    20                                                      
REMARK 465     ALA K    21                                                      
REMARK 465     VAL K    22                                                      
REMARK 465     GLY K    23                                                      
REMARK 465     ARG K    24                                                      
REMARK 465     ASN K    25                                                      
REMARK 465     ASP K    26                                                      
REMARK 465     ALA K    27                                                      
REMARK 465     PRO K    28                                                      
REMARK 465     VAL K    29                                                      
REMARK 465     GLU K    30                                                      
REMARK 465     ARG K    31                                                      
REMARK 465     ASP K    32                                                      
REMARK 465     ALA K    33                                                      
REMARK 465     ARG K    34                                                      
REMARK 465     HIS K   193                                                      
REMARK 465     ALA K   194                                                      
REMARK 465     GLU K   195                                                      
REMARK 465     SER K   196                                                      
REMARK 465     SER K   197                                                      
REMARK 465     SER K   198                                                      
REMARK 465     SER K   199                                                      
REMARK 465     SER K   200                                                      
REMARK 465     ASP K   201                                                      
REMARK 465     ASP K   202                                                      
REMARK 465     GLY K   203                                                      
REMARK 465     GLU K   204                                                      
REMARK 465     ALA K   205                                                      
REMARK 465     GLU K   206                                                      
REMARK 465     ASP K   207                                                      
REMARK 465     GLU K   208                                                      
REMARK 465     ALA K   209                                                      
REMARK 465     LYS K   343                                                      
REMARK 465     CYS K   344                                                      
REMARK 465     MET L     1                                                      
REMARK 465     SER L     2                                                      
REMARK 465     PRO L     3                                                      
REMARK 465     SER L     4                                                      
REMARK 465     VAL L     5                                                      
REMARK 465     LEU L     6                                                      
REMARK 465     GLU L     7                                                      
REMARK 465     PRO L     8                                                      
REMARK 465     GLN L     9                                                      
REMARK 465     SER L    10                                                      
REMARK 465     VAL L    11                                                      
REMARK 465     PRO L    12                                                      
REMARK 465     THR L    13                                                      
REMARK 465     LEU L    14                                                      
REMARK 465     VAL L    15                                                      
REMARK 465     ASN L    16                                                      
REMARK 465     VAL L    17                                                      
REMARK 465     GLY L    18                                                      
REMARK 465     LEU L    19                                                      
REMARK 465     LYS L    20                                                      
REMARK 465     ALA L    21                                                      
REMARK 465     VAL L    22                                                      
REMARK 465     GLY L    23                                                      
REMARK 465     ARG L    24                                                      
REMARK 465     ASN L    25                                                      
REMARK 465     ASP L    26                                                      
REMARK 465     ALA L    27                                                      
REMARK 465     PRO L    28                                                      
REMARK 465     VAL L    29                                                      
REMARK 465     GLU L    30                                                      
REMARK 465     ARG L    31                                                      
REMARK 465     ASP L    32                                                      
REMARK 465     ALA L    33                                                      
REMARK 465     ARG L    34                                                      
REMARK 465     HIS L   193                                                      
REMARK 465     ALA L   194                                                      
REMARK 465     GLU L   195                                                      
REMARK 465     SER L   196                                                      
REMARK 465     SER L   197                                                      
REMARK 465     SER L   198                                                      
REMARK 465     SER L   199                                                      
REMARK 465     SER L   200                                                      
REMARK 465     ASP L   201                                                      
REMARK 465     ASP L   202                                                      
REMARK 465     GLY L   203                                                      
REMARK 465     GLU L   204                                                      
REMARK 465     ALA L   205                                                      
REMARK 465     GLU L   206                                                      
REMARK 465     ASP L   207                                                      
REMARK 465     GLU L   208                                                      
REMARK 465     ALA L   209                                                      
REMARK 465     LYS L   343                                                      
REMARK 465     CYS L   344                                                      
REMARK 465     MET M     1                                                      
REMARK 465     SER M     2                                                      
REMARK 465     PRO M     3                                                      
REMARK 465     SER M     4                                                      
REMARK 465     VAL M     5                                                      
REMARK 465     LEU M     6                                                      
REMARK 465     GLU M     7                                                      
REMARK 465     PRO M     8                                                      
REMARK 465     GLN M     9                                                      
REMARK 465     SER M    10                                                      
REMARK 465     VAL M    11                                                      
REMARK 465     PRO M    12                                                      
REMARK 465     THR M    13                                                      
REMARK 465     LEU M    14                                                      
REMARK 465     VAL M    15                                                      
REMARK 465     ASN M    16                                                      
REMARK 465     VAL M    17                                                      
REMARK 465     GLY M    18                                                      
REMARK 465     LEU M    19                                                      
REMARK 465     LYS M    20                                                      
REMARK 465     ALA M    21                                                      
REMARK 465     VAL M    22                                                      
REMARK 465     GLY M    23                                                      
REMARK 465     ARG M    24                                                      
REMARK 465     ASN M    25                                                      
REMARK 465     ASP M    26                                                      
REMARK 465     ALA M    27                                                      
REMARK 465     PRO M    28                                                      
REMARK 465     VAL M    29                                                      
REMARK 465     GLU M    30                                                      
REMARK 465     ARG M    31                                                      
REMARK 465     ASP M    32                                                      
REMARK 465     ALA M    33                                                      
REMARK 465     ARG M    34                                                      
REMARK 465     HIS M   193                                                      
REMARK 465     ALA M   194                                                      
REMARK 465     GLU M   195                                                      
REMARK 465     SER M   196                                                      
REMARK 465     SER M   197                                                      
REMARK 465     SER M   198                                                      
REMARK 465     SER M   199                                                      
REMARK 465     SER M   200                                                      
REMARK 465     ASP M   201                                                      
REMARK 465     ASP M   202                                                      
REMARK 465     GLY M   203                                                      
REMARK 465     GLU M   204                                                      
REMARK 465     ALA M   205                                                      
REMARK 465     GLU M   206                                                      
REMARK 465     ASP M   207                                                      
REMARK 465     GLU M   208                                                      
REMARK 465     ALA M   209                                                      
REMARK 465     LYS M   343                                                      
REMARK 465     CYS M   344                                                      
REMARK 465     MET N     1                                                      
REMARK 465     SER N     2                                                      
REMARK 465     PRO N     3                                                      
REMARK 465     SER N     4                                                      
REMARK 465     VAL N     5                                                      
REMARK 465     LEU N     6                                                      
REMARK 465     GLU N     7                                                      
REMARK 465     PRO N     8                                                      
REMARK 465     GLN N     9                                                      
REMARK 465     SER N    10                                                      
REMARK 465     VAL N    11                                                      
REMARK 465     PRO N    12                                                      
REMARK 465     THR N    13                                                      
REMARK 465     LEU N    14                                                      
REMARK 465     VAL N    15                                                      
REMARK 465     ASN N    16                                                      
REMARK 465     VAL N    17                                                      
REMARK 465     GLY N    18                                                      
REMARK 465     LEU N    19                                                      
REMARK 465     LYS N    20                                                      
REMARK 465     ALA N    21                                                      
REMARK 465     VAL N    22                                                      
REMARK 465     GLY N    23                                                      
REMARK 465     ARG N    24                                                      
REMARK 465     ASN N    25                                                      
REMARK 465     ASP N    26                                                      
REMARK 465     ALA N    27                                                      
REMARK 465     PRO N    28                                                      
REMARK 465     VAL N    29                                                      
REMARK 465     GLU N    30                                                      
REMARK 465     ARG N    31                                                      
REMARK 465     ASP N    32                                                      
REMARK 465     ALA N    33                                                      
REMARK 465     ARG N    34                                                      
REMARK 465     HIS N   193                                                      
REMARK 465     ALA N   194                                                      
REMARK 465     GLU N   195                                                      
REMARK 465     SER N   196                                                      
REMARK 465     SER N   197                                                      
REMARK 465     SER N   198                                                      
REMARK 465     SER N   199                                                      
REMARK 465     SER N   200                                                      
REMARK 465     ASP N   201                                                      
REMARK 465     ASP N   202                                                      
REMARK 465     GLY N   203                                                      
REMARK 465     GLU N   204                                                      
REMARK 465     ALA N   205                                                      
REMARK 465     GLU N   206                                                      
REMARK 465     ASP N   207                                                      
REMARK 465     GLU N   208                                                      
REMARK 465     LYS N   343                                                      
REMARK 465     CYS N   344                                                      
REMARK 465     MET O     1                                                      
REMARK 465     SER O     2                                                      
REMARK 465     PRO O     3                                                      
REMARK 465     SER O     4                                                      
REMARK 465     VAL O     5                                                      
REMARK 465     LEU O     6                                                      
REMARK 465     GLU O     7                                                      
REMARK 465     PRO O     8                                                      
REMARK 465     GLN O     9                                                      
REMARK 465     SER O    10                                                      
REMARK 465     VAL O    11                                                      
REMARK 465     PRO O    12                                                      
REMARK 465     THR O    13                                                      
REMARK 465     LEU O    14                                                      
REMARK 465     VAL O    15                                                      
REMARK 465     ASN O    16                                                      
REMARK 465     VAL O    17                                                      
REMARK 465     GLY O    18                                                      
REMARK 465     LEU O    19                                                      
REMARK 465     LYS O    20                                                      
REMARK 465     ALA O    21                                                      
REMARK 465     VAL O    22                                                      
REMARK 465     GLY O    23                                                      
REMARK 465     ARG O    24                                                      
REMARK 465     ASN O    25                                                      
REMARK 465     ASP O    26                                                      
REMARK 465     ALA O    27                                                      
REMARK 465     PRO O    28                                                      
REMARK 465     VAL O    29                                                      
REMARK 465     GLU O    30                                                      
REMARK 465     ARG O    31                                                      
REMARK 465     ASP O    32                                                      
REMARK 465     ALA O    33                                                      
REMARK 465     ARG O    34                                                      
REMARK 465     HIS O   193                                                      
REMARK 465     ALA O   194                                                      
REMARK 465     GLU O   195                                                      
REMARK 465     SER O   196                                                      
REMARK 465     SER O   197                                                      
REMARK 465     SER O   198                                                      
REMARK 465     SER O   199                                                      
REMARK 465     SER O   200                                                      
REMARK 465     ASP O   201                                                      
REMARK 465     ASP O   202                                                      
REMARK 465     GLY O   203                                                      
REMARK 465     GLU O   204                                                      
REMARK 465     ALA O   205                                                      
REMARK 465     GLU O   206                                                      
REMARK 465     ASP O   207                                                      
REMARK 465     GLU O   208                                                      
REMARK 465     LYS O   343                                                      
REMARK 465     CYS O   344                                                      
REMARK 465     MET P     1                                                      
REMARK 465     SER P     2                                                      
REMARK 465     PRO P     3                                                      
REMARK 465     SER P     4                                                      
REMARK 465     VAL P     5                                                      
REMARK 465     LEU P     6                                                      
REMARK 465     GLU P     7                                                      
REMARK 465     PRO P     8                                                      
REMARK 465     GLN P     9                                                      
REMARK 465     SER P    10                                                      
REMARK 465     VAL P    11                                                      
REMARK 465     PRO P    12                                                      
REMARK 465     THR P    13                                                      
REMARK 465     LEU P    14                                                      
REMARK 465     VAL P    15                                                      
REMARK 465     ASN P    16                                                      
REMARK 465     VAL P    17                                                      
REMARK 465     GLY P    18                                                      
REMARK 465     LEU P    19                                                      
REMARK 465     LYS P    20                                                      
REMARK 465     ALA P    21                                                      
REMARK 465     VAL P    22                                                      
REMARK 465     GLY P    23                                                      
REMARK 465     ARG P    24                                                      
REMARK 465     ASN P    25                                                      
REMARK 465     ASP P    26                                                      
REMARK 465     ALA P    27                                                      
REMARK 465     PRO P    28                                                      
REMARK 465     VAL P    29                                                      
REMARK 465     GLU P    30                                                      
REMARK 465     ARG P    31                                                      
REMARK 465     ASP P    32                                                      
REMARK 465     ALA P    33                                                      
REMARK 465     ARG P    34                                                      
REMARK 465     HIS P   193                                                      
REMARK 465     ALA P   194                                                      
REMARK 465     GLU P   195                                                      
REMARK 465     SER P   196                                                      
REMARK 465     SER P   197                                                      
REMARK 465     SER P   198                                                      
REMARK 465     SER P   199                                                      
REMARK 465     SER P   200                                                      
REMARK 465     ASP P   201                                                      
REMARK 465     ASP P   202                                                      
REMARK 465     GLY P   203                                                      
REMARK 465     GLU P   204                                                      
REMARK 465     ALA P   205                                                      
REMARK 465     GLU P   206                                                      
REMARK 465     ASP P   207                                                      
REMARK 465     GLU P   208                                                      
REMARK 465     ALA P   209                                                      
REMARK 465     LYS P   343                                                      
REMARK 465     CYS P   344                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     PHE A 253    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE B 253    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE C 253    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE D 253    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE E 253    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE F 253    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE G 253    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE H 253    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE I 253    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE J 253    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE K 253    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE L 253    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE M 253    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE N 253    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE O 253    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE P 253    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    THR A  53      135.16   -171.54                                   
REMARK 500    ALA A  87       46.85    -83.33                                   
REMARK 500    PRO A 135       32.18    -92.10                                   
REMARK 500    ARG A 269     -174.72    167.16                                   
REMARK 500    ASP A 277       86.36   -150.62                                   
REMARK 500    PRO A 314       52.67    -69.78                                   
REMARK 500    THR B  53      141.29   -171.73                                   
REMARK 500    ALA B  87       60.78   -101.09                                   
REMARK 500    ASP B 229       30.32    -87.91                                   
REMARK 500    GLN B 230     -175.83   -176.99                                   
REMARK 500    ASP B 250      136.49    -35.76                                   
REMARK 500    ARG B 269     -175.93   -171.84                                   
REMARK 500    ASP B 277       85.26   -155.95                                   
REMARK 500    ALA C  87       41.32    -86.77                                   
REMARK 500    ASN C 219      153.81    173.72                                   
REMARK 500    HIS C 227       30.91    -76.77                                   
REMARK 500    ASP C 228      -43.86   -141.60                                   
REMARK 500    ASP C 229        8.13    -65.78                                   
REMARK 500    ARG C 269     -169.42    157.77                                   
REMARK 500    ASP C 277       86.74   -156.17                                   
REMARK 500    ARG C 290     -179.44   -172.04                                   
REMARK 500    PRO C 314       63.10    -69.55                                   
REMARK 500    THR D  53      142.13   -174.21                                   
REMARK 500    ALA D  87       43.29    -92.51                                   
REMARK 500    SER D 128      -61.27    -93.05                                   
REMARK 500    ALA D 129      125.03    -35.27                                   
REMARK 500    LYS D 157      -57.93    -26.42                                   
REMARK 500    PHE D 179       78.47   -101.29                                   
REMARK 500    HIS D 227       25.99    -73.46                                   
REMARK 500    ASP D 228      -24.28   -141.41                                   
REMARK 500    GLN D 230     -175.88   -176.91                                   
REMARK 500    ASP D 250      139.88    -34.10                                   
REMARK 500    ALA D 255       71.12     44.55                                   
REMARK 500    ARG D 269     -168.95    173.93                                   
REMARK 500    ASP D 277       81.35   -155.09                                   
REMARK 500    PRO D 314       58.33    -69.07                                   
REMARK 500    ALA E  87       49.54    -96.71                                   
REMARK 500    PRO E 135       30.39    -85.61                                   
REMARK 500    HIS E 227       36.10    -79.92                                   
REMARK 500    ASP E 228      -49.11   -143.37                                   
REMARK 500    ASP E 229       19.12    -62.06                                   
REMARK 500    ASP E 250      154.10    -32.91                                   
REMARK 500    ARG E 269      179.14    167.44                                   
REMARK 500    PRO E 314       51.51    -69.93                                   
REMARK 500    ASP F  81      -60.40    -96.30                                   
REMARK 500    ALA F  87       49.40    -89.10                                   
REMARK 500    ALA F 129      130.01    -37.03                                   
REMARK 500    HIS F 227       34.61    -73.41                                   
REMARK 500    ASP F 228      -43.11   -151.41                                   
REMARK 500    ASP F 229       15.51    -61.46                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     141 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FE2 C 345  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS C 249   NE2                                                    
REMARK 620 2 AHZ C 500   N3T  84.9                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FE2 G 345  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS G 249   NE2                                                    
REMARK 620 2 AHZ G 500   N3T  84.6                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FE2 H 345  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS H 249   NE2                                                    
REMARK 620 2 AHZ H 500   N3T  98.4                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FE2 I 345  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS I 249   NE2                                                    
REMARK 620 2 AHZ I 500   N3T  91.3                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FE2 K 345  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS K 249   NE2                                                    
REMARK 620 2 AHZ K 500   N3T  86.8                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FE2 N 345  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS N 249   NE2                                                    
REMARK 620 2 AHZ N 500   N3T 102.0                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FE2 A 345  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 AHZ A 500   N3T                                                    
REMARK 620 2 HIS A 249   NE2  94.3                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FE2 B 345  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 AHZ B 500   N3T                                                    
REMARK 620 2 HIS B 249   NE2  88.2                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FE2 D 345  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 AHZ D 500   N3T                                                    
REMARK 620 2 HIS D 249   NE2  95.7                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FE2 E 345  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 AHZ E 500   N3T                                                    
REMARK 620 2 HIS E 249   NE2  83.1                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FE2 J 345  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 AHZ J 500   N3T                                                    
REMARK 620 2 HIS J 249   NE2  84.5                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FE2 L 345  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 AHZ L 500   N3T                                                    
REMARK 620 2 HIS L 249   NE2  88.4                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FE2 M 345  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 AHZ M 500   N3T                                                    
REMARK 620 2 HIS M 249   NE2  93.5                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             FE2 F 345  FE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 AHZ F 500   N3T                                                    
REMARK 620 2 HIS F 249   NE2  89.8                                              
REMARK 620 N                    1                                               
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AHZ A 500                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FE2 A 345                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AHZ B 500                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FE2 B 345                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AHZ C 500                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FE2 C 345                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AHZ D 500                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FE2 D 345                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AHZ E 500                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FE2 E 345                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AHZ F 500                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FE2 F 345                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AHZ G 500                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FE2 G 345                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AHZ H 500                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FE2 H 345                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AHZ I 500                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FE2 I 345                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AHZ J 500                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FE2 J 345                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AHZ K 500                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FE2 K 345                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FE2 K 346                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AHZ L 500                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FE2 L 345                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AHZ M 500                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FE2 M 345                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FE2 M 346                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AHZ N 500                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE FE2 N 345                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AHZ O 500                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AHZ P 500                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 2GJC   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 1RP0   RELATED DB: PDB                                   
DBREF  3JSK A    1   344  UNP    Q9HGR2   Q9HGR2_NEUCR     1    344             
DBREF  3JSK B    1   344  UNP    Q9HGR2   Q9HGR2_NEUCR     1    344             
DBREF  3JSK C    1   344  UNP    Q9HGR2   Q9HGR2_NEUCR     1    344             
DBREF  3JSK D    1   344  UNP    Q9HGR2   Q9HGR2_NEUCR     1    344             
DBREF  3JSK E    1   344  UNP    Q9HGR2   Q9HGR2_NEUCR     1    344             
DBREF  3JSK F    1   344  UNP    Q9HGR2   Q9HGR2_NEUCR     1    344             
DBREF  3JSK G    1   344  UNP    Q9HGR2   Q9HGR2_NEUCR     1    344             
DBREF  3JSK H    1   344  UNP    Q9HGR2   Q9HGR2_NEUCR     1    344             
DBREF  3JSK I    1   344  UNP    Q9HGR2   Q9HGR2_NEUCR     1    344             
DBREF  3JSK J    1   344  UNP    Q9HGR2   Q9HGR2_NEUCR     1    344             
DBREF  3JSK K    1   344  UNP    Q9HGR2   Q9HGR2_NEUCR     1    344             
DBREF  3JSK L    1   344  UNP    Q9HGR2   Q9HGR2_NEUCR     1    344             
DBREF  3JSK M    1   344  UNP    Q9HGR2   Q9HGR2_NEUCR     1    344             
DBREF  3JSK N    1   344  UNP    Q9HGR2   Q9HGR2_NEUCR     1    344             
DBREF  3JSK O    1   344  UNP    Q9HGR2   Q9HGR2_NEUCR     1    344             
DBREF  3JSK P    1   344  UNP    Q9HGR2   Q9HGR2_NEUCR     1    344             
SEQADV 3JSK DHA A  232  UNP  Q9HGR2    CYS   232 ENGINEERED                     
SEQADV 3JSK DHA B  232  UNP  Q9HGR2    CYS   232 ENGINEERED                     
SEQADV 3JSK DHA C  232  UNP  Q9HGR2    CYS   232 ENGINEERED                     
SEQADV 3JSK DHA D  232  UNP  Q9HGR2    CYS   232 ENGINEERED                     
SEQADV 3JSK DHA E  232  UNP  Q9HGR2    CYS   232 ENGINEERED                     
SEQADV 3JSK DHA F  232  UNP  Q9HGR2    CYS   232 ENGINEERED                     
SEQADV 3JSK DHA G  232  UNP  Q9HGR2    CYS   232 ENGINEERED                     
SEQADV 3JSK DHA H  232  UNP  Q9HGR2    CYS   232 ENGINEERED                     
SEQADV 3JSK DHA I  232  UNP  Q9HGR2    CYS   232 ENGINEERED                     
SEQADV 3JSK DHA J  232  UNP  Q9HGR2    CYS   232 ENGINEERED                     
SEQADV 3JSK DHA K  232  UNP  Q9HGR2    CYS   232 ENGINEERED                     
SEQADV 3JSK DHA L  232  UNP  Q9HGR2    CYS   232 ENGINEERED                     
SEQADV 3JSK DHA M  232  UNP  Q9HGR2    CYS   232 ENGINEERED                     
SEQADV 3JSK DHA N  232  UNP  Q9HGR2    CYS   232 ENGINEERED                     
SEQADV 3JSK DHA O  232  UNP  Q9HGR2    CYS   232 ENGINEERED                     
SEQADV 3JSK DHA P  232  UNP  Q9HGR2    CYS   232 ENGINEERED                     
SEQRES   1 A  344  MET SER PRO SER VAL LEU GLU PRO GLN SER VAL PRO THR          
SEQRES   2 A  344  LEU VAL ASN VAL GLY LEU LYS ALA VAL GLY ARG ASN ASP          
SEQRES   3 A  344  ALA PRO VAL GLU ARG ASP ALA ARG GLY LEU SER LYS PRO          
SEQRES   4 A  344  LEU LEU GLU LEU MET PRO THR LEU GLY THR ASP ALA PHE          
SEQRES   5 A  344  THR PHE SER PRO ILE ARG GLU SER THR VAL SER ARG ALA          
SEQRES   6 A  344  MET THR ARG ARG TYR PHE ALA ASP LEU ASP ALA HIS ALA          
SEQRES   7 A  344  GLU THR ASP ILE VAL ILE VAL GLY ALA GLY SER CYS GLY          
SEQRES   8 A  344  LEU SER ALA ALA TYR VAL LEU SER THR LEU ARG PRO ASP          
SEQRES   9 A  344  LEU ARG ILE THR ILE VAL GLU ALA GLY VAL ALA PRO GLY          
SEQRES  10 A  344  GLY GLY ALA TRP LEU GLY GLY GLN LEU PHE SER ALA MET          
SEQRES  11 A  344  VAL MET ARG LYS PRO ALA ASP VAL PHE LEU ASP GLU VAL          
SEQRES  12 A  344  GLY VAL PRO TYR GLU ASP GLU GLY ASP TYR VAL VAL VAL          
SEQRES  13 A  344  LYS HIS ALA ALA LEU PHE THR SER THR VAL LEU SER LYS          
SEQRES  14 A  344  VAL LEU GLN ARG PRO ASN VAL LYS LEU PHE ASN ALA THR          
SEQRES  15 A  344  THR VAL GLU ASP LEU ILE THR ARG LYS HIS HIS ALA GLU          
SEQRES  16 A  344  SER SER SER SER SER ASP ASP GLY GLU ALA GLU ASP GLU          
SEQRES  17 A  344  ALA LYS VAL ARG ILE ALA GLY VAL VAL THR ASN TRP THR          
SEQRES  18 A  344  LEU VAL SER MET HIS HIS ASP ASP GLN SER DHA MET ASP          
SEQRES  19 A  344  PRO ASN THR ILE ASN ALA PRO VAL ILE ILE SER THR THR          
SEQRES  20 A  344  GLY HIS ASP GLY PRO PHE GLY ALA PHE SER VAL LYS ARG          
SEQRES  21 A  344  LEU VAL SER MET LYS GLN MET GLU ARG LEU ASN GLY MET          
SEQRES  22 A  344  ARG GLY LEU ASP MET GLN SER ALA GLU ASP ALA ILE VAL          
SEQRES  23 A  344  ASN ASN THR ARG GLU ILE VAL PRO GLY LEU ILE VAL GLY          
SEQRES  24 A  344  GLY MET GLU LEU SER GLU ILE ASP GLY ALA ASN ARG MET          
SEQRES  25 A  344  GLY PRO THR PHE GLY ALA MET ALA LEU SER GLY VAL LYS          
SEQRES  26 A  344  ALA ALA HIS GLU ALA ILE ARG VAL PHE ASP LEU ARG LYS          
SEQRES  27 A  344  ALA GLN ASN ASP LYS CYS                                      
SEQRES   1 B  344  MET SER PRO SER VAL LEU GLU PRO GLN SER VAL PRO THR          
SEQRES   2 B  344  LEU VAL ASN VAL GLY LEU LYS ALA VAL GLY ARG ASN ASP          
SEQRES   3 B  344  ALA PRO VAL GLU ARG ASP ALA ARG GLY LEU SER LYS PRO          
SEQRES   4 B  344  LEU LEU GLU LEU MET PRO THR LEU GLY THR ASP ALA PHE          
SEQRES   5 B  344  THR PHE SER PRO ILE ARG GLU SER THR VAL SER ARG ALA          
SEQRES   6 B  344  MET THR ARG ARG TYR PHE ALA ASP LEU ASP ALA HIS ALA          
SEQRES   7 B  344  GLU THR ASP ILE VAL ILE VAL GLY ALA GLY SER CYS GLY          
SEQRES   8 B  344  LEU SER ALA ALA TYR VAL LEU SER THR LEU ARG PRO ASP          
SEQRES   9 B  344  LEU ARG ILE THR ILE VAL GLU ALA GLY VAL ALA PRO GLY          
SEQRES  10 B  344  GLY GLY ALA TRP LEU GLY GLY GLN LEU PHE SER ALA MET          
SEQRES  11 B  344  VAL MET ARG LYS PRO ALA ASP VAL PHE LEU ASP GLU VAL          
SEQRES  12 B  344  GLY VAL PRO TYR GLU ASP GLU GLY ASP TYR VAL VAL VAL          
SEQRES  13 B  344  LYS HIS ALA ALA LEU PHE THR SER THR VAL LEU SER LYS          
SEQRES  14 B  344  VAL LEU GLN ARG PRO ASN VAL LYS LEU PHE ASN ALA THR          
SEQRES  15 B  344  THR VAL GLU ASP LEU ILE THR ARG LYS HIS HIS ALA GLU          
SEQRES  16 B  344  SER SER SER SER SER ASP ASP GLY GLU ALA GLU ASP GLU          
SEQRES  17 B  344  ALA LYS VAL ARG ILE ALA GLY VAL VAL THR ASN TRP THR          
SEQRES  18 B  344  LEU VAL SER MET HIS HIS ASP ASP GLN SER DHA MET ASP          
SEQRES  19 B  344  PRO ASN THR ILE ASN ALA PRO VAL ILE ILE SER THR THR          
SEQRES  20 B  344  GLY HIS ASP GLY PRO PHE GLY ALA PHE SER VAL LYS ARG          
SEQRES  21 B  344  LEU VAL SER MET LYS GLN MET GLU ARG LEU ASN GLY MET          
SEQRES  22 B  344  ARG GLY LEU ASP MET GLN SER ALA GLU ASP ALA ILE VAL          
SEQRES  23 B  344  ASN ASN THR ARG GLU ILE VAL PRO GLY LEU ILE VAL GLY          
SEQRES  24 B  344  GLY MET GLU LEU SER GLU ILE ASP GLY ALA ASN ARG MET          
SEQRES  25 B  344  GLY PRO THR PHE GLY ALA MET ALA LEU SER GLY VAL LYS          
SEQRES  26 B  344  ALA ALA HIS GLU ALA ILE ARG VAL PHE ASP LEU ARG LYS          
SEQRES  27 B  344  ALA GLN ASN ASP LYS CYS                                      
SEQRES   1 C  344  MET SER PRO SER VAL LEU GLU PRO GLN SER VAL PRO THR          
SEQRES   2 C  344  LEU VAL ASN VAL GLY LEU LYS ALA VAL GLY ARG ASN ASP          
SEQRES   3 C  344  ALA PRO VAL GLU ARG ASP ALA ARG GLY LEU SER LYS PRO          
SEQRES   4 C  344  LEU LEU GLU LEU MET PRO THR LEU GLY THR ASP ALA PHE          
SEQRES   5 C  344  THR PHE SER PRO ILE ARG GLU SER THR VAL SER ARG ALA          
SEQRES   6 C  344  MET THR ARG ARG TYR PHE ALA ASP LEU ASP ALA HIS ALA          
SEQRES   7 C  344  GLU THR ASP ILE VAL ILE VAL GLY ALA GLY SER CYS GLY          
SEQRES   8 C  344  LEU SER ALA ALA TYR VAL LEU SER THR LEU ARG PRO ASP          
SEQRES   9 C  344  LEU ARG ILE THR ILE VAL GLU ALA GLY VAL ALA PRO GLY          
SEQRES  10 C  344  GLY GLY ALA TRP LEU GLY GLY GLN LEU PHE SER ALA MET          
SEQRES  11 C  344  VAL MET ARG LYS PRO ALA ASP VAL PHE LEU ASP GLU VAL          
SEQRES  12 C  344  GLY VAL PRO TYR GLU ASP GLU GLY ASP TYR VAL VAL VAL          
SEQRES  13 C  344  LYS HIS ALA ALA LEU PHE THR SER THR VAL LEU SER LYS          
SEQRES  14 C  344  VAL LEU GLN ARG PRO ASN VAL LYS LEU PHE ASN ALA THR          
SEQRES  15 C  344  THR VAL GLU ASP LEU ILE THR ARG LYS HIS HIS ALA GLU          
SEQRES  16 C  344  SER SER SER SER SER ASP ASP GLY GLU ALA GLU ASP GLU          
SEQRES  17 C  344  ALA LYS VAL ARG ILE ALA GLY VAL VAL THR ASN TRP THR          
SEQRES  18 C  344  LEU VAL SER MET HIS HIS ASP ASP GLN SER DHA MET ASP          
SEQRES  19 C  344  PRO ASN THR ILE ASN ALA PRO VAL ILE ILE SER THR THR          
SEQRES  20 C  344  GLY HIS ASP GLY PRO PHE GLY ALA PHE SER VAL LYS ARG          
SEQRES  21 C  344  LEU VAL SER MET LYS GLN MET GLU ARG LEU ASN GLY MET          
SEQRES  22 C  344  ARG GLY LEU ASP MET GLN SER ALA GLU ASP ALA ILE VAL          
SEQRES  23 C  344  ASN ASN THR ARG GLU ILE VAL PRO GLY LEU ILE VAL GLY          
SEQRES  24 C  344  GLY MET GLU LEU SER GLU ILE ASP GLY ALA ASN ARG MET          
SEQRES  25 C  344  GLY PRO THR PHE GLY ALA MET ALA LEU SER GLY VAL LYS          
SEQRES  26 C  344  ALA ALA HIS GLU ALA ILE ARG VAL PHE ASP LEU ARG LYS          
SEQRES  27 C  344  ALA GLN ASN ASP LYS CYS                                      
SEQRES   1 D  344  MET SER PRO SER VAL LEU GLU PRO GLN SER VAL PRO THR          
SEQRES   2 D  344  LEU VAL ASN VAL GLY LEU LYS ALA VAL GLY ARG ASN ASP          
SEQRES   3 D  344  ALA PRO VAL GLU ARG ASP ALA ARG GLY LEU SER LYS PRO          
SEQRES   4 D  344  LEU LEU GLU LEU MET PRO THR LEU GLY THR ASP ALA PHE          
SEQRES   5 D  344  THR PHE SER PRO ILE ARG GLU SER THR VAL SER ARG ALA          
SEQRES   6 D  344  MET THR ARG ARG TYR PHE ALA ASP LEU ASP ALA HIS ALA          
SEQRES   7 D  344  GLU THR ASP ILE VAL ILE VAL GLY ALA GLY SER CYS GLY          
SEQRES   8 D  344  LEU SER ALA ALA TYR VAL LEU SER THR LEU ARG PRO ASP          
SEQRES   9 D  344  LEU ARG ILE THR ILE VAL GLU ALA GLY VAL ALA PRO GLY          
SEQRES  10 D  344  GLY GLY ALA TRP LEU GLY GLY GLN LEU PHE SER ALA MET          
SEQRES  11 D  344  VAL MET ARG LYS PRO ALA ASP VAL PHE LEU ASP GLU VAL          
SEQRES  12 D  344  GLY VAL PRO TYR GLU ASP GLU GLY ASP TYR VAL VAL VAL          
SEQRES  13 D  344  LYS HIS ALA ALA LEU PHE THR SER THR VAL LEU SER LYS          
SEQRES  14 D  344  VAL LEU GLN ARG PRO ASN VAL LYS LEU PHE ASN ALA THR          
SEQRES  15 D  344  THR VAL GLU ASP LEU ILE THR ARG LYS HIS HIS ALA GLU          
SEQRES  16 D  344  SER SER SER SER SER ASP ASP GLY GLU ALA GLU ASP GLU          
SEQRES  17 D  344  ALA LYS VAL ARG ILE ALA GLY VAL VAL THR ASN TRP THR          
SEQRES  18 D  344  LEU VAL SER MET HIS HIS ASP ASP GLN SER DHA MET ASP          
SEQRES  19 D  344  PRO ASN THR ILE ASN ALA PRO VAL ILE ILE SER THR THR          
SEQRES  20 D  344  GLY HIS ASP GLY PRO PHE GLY ALA PHE SER VAL LYS ARG          
SEQRES  21 D  344  LEU VAL SER MET LYS GLN MET GLU ARG LEU ASN GLY MET          
SEQRES  22 D  344  ARG GLY LEU ASP MET GLN SER ALA GLU ASP ALA ILE VAL          
SEQRES  23 D  344  ASN ASN THR ARG GLU ILE VAL PRO GLY LEU ILE VAL GLY          
SEQRES  24 D  344  GLY MET GLU LEU SER GLU ILE ASP GLY ALA ASN ARG MET          
SEQRES  25 D  344  GLY PRO THR PHE GLY ALA MET ALA LEU SER GLY VAL LYS          
SEQRES  26 D  344  ALA ALA HIS GLU ALA ILE ARG VAL PHE ASP LEU ARG LYS          
SEQRES  27 D  344  ALA GLN ASN ASP LYS CYS                                      
SEQRES   1 E  344  MET SER PRO SER VAL LEU GLU PRO GLN SER VAL PRO THR          
SEQRES   2 E  344  LEU VAL ASN VAL GLY LEU LYS ALA VAL GLY ARG ASN ASP          
SEQRES   3 E  344  ALA PRO VAL GLU ARG ASP ALA ARG GLY LEU SER LYS PRO          
SEQRES   4 E  344  LEU LEU GLU LEU MET PRO THR LEU GLY THR ASP ALA PHE          
SEQRES   5 E  344  THR PHE SER PRO ILE ARG GLU SER THR VAL SER ARG ALA          
SEQRES   6 E  344  MET THR ARG ARG TYR PHE ALA ASP LEU ASP ALA HIS ALA          
SEQRES   7 E  344  GLU THR ASP ILE VAL ILE VAL GLY ALA GLY SER CYS GLY          
SEQRES   8 E  344  LEU SER ALA ALA TYR VAL LEU SER THR LEU ARG PRO ASP          
SEQRES   9 E  344  LEU ARG ILE THR ILE VAL GLU ALA GLY VAL ALA PRO GLY          
SEQRES  10 E  344  GLY GLY ALA TRP LEU GLY GLY GLN LEU PHE SER ALA MET          
SEQRES  11 E  344  VAL MET ARG LYS PRO ALA ASP VAL PHE LEU ASP GLU VAL          
SEQRES  12 E  344  GLY VAL PRO TYR GLU ASP GLU GLY ASP TYR VAL VAL VAL          
SEQRES  13 E  344  LYS HIS ALA ALA LEU PHE THR SER THR VAL LEU SER LYS          
SEQRES  14 E  344  VAL LEU GLN ARG PRO ASN VAL LYS LEU PHE ASN ALA THR          
SEQRES  15 E  344  THR VAL GLU ASP LEU ILE THR ARG LYS HIS HIS ALA GLU          
SEQRES  16 E  344  SER SER SER SER SER ASP ASP GLY GLU ALA GLU ASP GLU          
SEQRES  17 E  344  ALA LYS VAL ARG ILE ALA GLY VAL VAL THR ASN TRP THR          
SEQRES  18 E  344  LEU VAL SER MET HIS HIS ASP ASP GLN SER DHA MET ASP          
SEQRES  19 E  344  PRO ASN THR ILE ASN ALA PRO VAL ILE ILE SER THR THR          
SEQRES  20 E  344  GLY HIS ASP GLY PRO PHE GLY ALA PHE SER VAL LYS ARG          
SEQRES  21 E  344  LEU VAL SER MET LYS GLN MET GLU ARG LEU ASN GLY MET          
SEQRES  22 E  344  ARG GLY LEU ASP MET GLN SER ALA GLU ASP ALA ILE VAL          
SEQRES  23 E  344  ASN ASN THR ARG GLU ILE VAL PRO GLY LEU ILE VAL GLY          
SEQRES  24 E  344  GLY MET GLU LEU SER GLU ILE ASP GLY ALA ASN ARG MET          
SEQRES  25 E  344  GLY PRO THR PHE GLY ALA MET ALA LEU SER GLY VAL LYS          
SEQRES  26 E  344  ALA ALA HIS GLU ALA ILE ARG VAL PHE ASP LEU ARG LYS          
SEQRES  27 E  344  ALA GLN ASN ASP LYS CYS                                      
SEQRES   1 F  344  MET SER PRO SER VAL LEU GLU PRO GLN SER VAL PRO THR          
SEQRES   2 F  344  LEU VAL ASN VAL GLY LEU LYS ALA VAL GLY ARG ASN ASP          
SEQRES   3 F  344  ALA PRO VAL GLU ARG ASP ALA ARG GLY LEU SER LYS PRO          
SEQRES   4 F  344  LEU LEU GLU LEU MET PRO THR LEU GLY THR ASP ALA PHE          
SEQRES   5 F  344  THR PHE SER PRO ILE ARG GLU SER THR VAL SER ARG ALA          
SEQRES   6 F  344  MET THR ARG ARG TYR PHE ALA ASP LEU ASP ALA HIS ALA          
SEQRES   7 F  344  GLU THR ASP ILE VAL ILE VAL GLY ALA GLY SER CYS GLY          
SEQRES   8 F  344  LEU SER ALA ALA TYR VAL LEU SER THR LEU ARG PRO ASP          
SEQRES   9 F  344  LEU ARG ILE THR ILE VAL GLU ALA GLY VAL ALA PRO GLY          
SEQRES  10 F  344  GLY GLY ALA TRP LEU GLY GLY GLN LEU PHE SER ALA MET          
SEQRES  11 F  344  VAL MET ARG LYS PRO ALA ASP VAL PHE LEU ASP GLU VAL          
SEQRES  12 F  344  GLY VAL PRO TYR GLU ASP GLU GLY ASP TYR VAL VAL VAL          
SEQRES  13 F  344  LYS HIS ALA ALA LEU PHE THR SER THR VAL LEU SER LYS          
SEQRES  14 F  344  VAL LEU GLN ARG PRO ASN VAL LYS LEU PHE ASN ALA THR          
SEQRES  15 F  344  THR VAL GLU ASP LEU ILE THR ARG LYS HIS HIS ALA GLU          
SEQRES  16 F  344  SER SER SER SER SER ASP ASP GLY GLU ALA GLU ASP GLU          
SEQRES  17 F  344  ALA LYS VAL ARG ILE ALA GLY VAL VAL THR ASN TRP THR          
SEQRES  18 F  344  LEU VAL SER MET HIS HIS ASP ASP GLN SER DHA MET ASP          
SEQRES  19 F  344  PRO ASN THR ILE ASN ALA PRO VAL ILE ILE SER THR THR          
SEQRES  20 F  344  GLY HIS ASP GLY PRO PHE GLY ALA PHE SER VAL LYS ARG          
SEQRES  21 F  344  LEU VAL SER MET LYS GLN MET GLU ARG LEU ASN GLY MET          
SEQRES  22 F  344  ARG GLY LEU ASP MET GLN SER ALA GLU ASP ALA ILE VAL          
SEQRES  23 F  344  ASN ASN THR ARG GLU ILE VAL PRO GLY LEU ILE VAL GLY          
SEQRES  24 F  344  GLY MET GLU LEU SER GLU ILE ASP GLY ALA ASN ARG MET          
SEQRES  25 F  344  GLY PRO THR PHE GLY ALA MET ALA LEU SER GLY VAL LYS          
SEQRES  26 F  344  ALA ALA HIS GLU ALA ILE ARG VAL PHE ASP LEU ARG LYS          
SEQRES  27 F  344  ALA GLN ASN ASP LYS CYS                                      
SEQRES   1 G  344  MET SER PRO SER VAL LEU GLU PRO GLN SER VAL PRO THR          
SEQRES   2 G  344  LEU VAL ASN VAL GLY LEU LYS ALA VAL GLY ARG ASN ASP          
SEQRES   3 G  344  ALA PRO VAL GLU ARG ASP ALA ARG GLY LEU SER LYS PRO          
SEQRES   4 G  344  LEU LEU GLU LEU MET PRO THR LEU GLY THR ASP ALA PHE          
SEQRES   5 G  344  THR PHE SER PRO ILE ARG GLU SER THR VAL SER ARG ALA          
SEQRES   6 G  344  MET THR ARG ARG TYR PHE ALA ASP LEU ASP ALA HIS ALA          
SEQRES   7 G  344  GLU THR ASP ILE VAL ILE VAL GLY ALA GLY SER CYS GLY          
SEQRES   8 G  344  LEU SER ALA ALA TYR VAL LEU SER THR LEU ARG PRO ASP          
SEQRES   9 G  344  LEU ARG ILE THR ILE VAL GLU ALA GLY VAL ALA PRO GLY          
SEQRES  10 G  344  GLY GLY ALA TRP LEU GLY GLY GLN LEU PHE SER ALA MET          
SEQRES  11 G  344  VAL MET ARG LYS PRO ALA ASP VAL PHE LEU ASP GLU VAL          
SEQRES  12 G  344  GLY VAL PRO TYR GLU ASP GLU GLY ASP TYR VAL VAL VAL          
SEQRES  13 G  344  LYS HIS ALA ALA LEU PHE THR SER THR VAL LEU SER LYS          
SEQRES  14 G  344  VAL LEU GLN ARG PRO ASN VAL LYS LEU PHE ASN ALA THR          
SEQRES  15 G  344  THR VAL GLU ASP LEU ILE THR ARG LYS HIS HIS ALA GLU          
SEQRES  16 G  344  SER SER SER SER SER ASP ASP GLY GLU ALA GLU ASP GLU          
SEQRES  17 G  344  ALA LYS VAL ARG ILE ALA GLY VAL VAL THR ASN TRP THR          
SEQRES  18 G  344  LEU VAL SER MET HIS HIS ASP ASP GLN SER DHA MET ASP          
SEQRES  19 G  344  PRO ASN THR ILE ASN ALA PRO VAL ILE ILE SER THR THR          
SEQRES  20 G  344  GLY HIS ASP GLY PRO PHE GLY ALA PHE SER VAL LYS ARG          
SEQRES  21 G  344  LEU VAL SER MET LYS GLN MET GLU ARG LEU ASN GLY MET          
SEQRES  22 G  344  ARG GLY LEU ASP MET GLN SER ALA GLU ASP ALA ILE VAL          
SEQRES  23 G  344  ASN ASN THR ARG GLU ILE VAL PRO GLY LEU ILE VAL GLY          
SEQRES  24 G  344  GLY MET GLU LEU SER GLU ILE ASP GLY ALA ASN ARG MET          
SEQRES  25 G  344  GLY PRO THR PHE GLY ALA MET ALA LEU SER GLY VAL LYS          
SEQRES  26 G  344  ALA ALA HIS GLU ALA ILE ARG VAL PHE ASP LEU ARG LYS          
SEQRES  27 G  344  ALA GLN ASN ASP LYS CYS                                      
SEQRES   1 H  344  MET SER PRO SER VAL LEU GLU PRO GLN SER VAL PRO THR          
SEQRES   2 H  344  LEU VAL ASN VAL GLY LEU LYS ALA VAL GLY ARG ASN ASP          
SEQRES   3 H  344  ALA PRO VAL GLU ARG ASP ALA ARG GLY LEU SER LYS PRO          
SEQRES   4 H  344  LEU LEU GLU LEU MET PRO THR LEU GLY THR ASP ALA PHE          
SEQRES   5 H  344  THR PHE SER PRO ILE ARG GLU SER THR VAL SER ARG ALA          
SEQRES   6 H  344  MET THR ARG ARG TYR PHE ALA ASP LEU ASP ALA HIS ALA          
SEQRES   7 H  344  GLU THR ASP ILE VAL ILE VAL GLY ALA GLY SER CYS GLY          
SEQRES   8 H  344  LEU SER ALA ALA TYR VAL LEU SER THR LEU ARG PRO ASP          
SEQRES   9 H  344  LEU ARG ILE THR ILE VAL GLU ALA GLY VAL ALA PRO GLY          
SEQRES  10 H  344  GLY GLY ALA TRP LEU GLY GLY GLN LEU PHE SER ALA MET          
SEQRES  11 H  344  VAL MET ARG LYS PRO ALA ASP VAL PHE LEU ASP GLU VAL          
SEQRES  12 H  344  GLY VAL PRO TYR GLU ASP GLU GLY ASP TYR VAL VAL VAL          
SEQRES  13 H  344  LYS HIS ALA ALA LEU PHE THR SER THR VAL LEU SER LYS          
SEQRES  14 H  344  VAL LEU GLN ARG PRO ASN VAL LYS LEU PHE ASN ALA THR          
SEQRES  15 H  344  THR VAL GLU ASP LEU ILE THR ARG LYS HIS HIS ALA GLU          
SEQRES  16 H  344  SER SER SER SER SER ASP ASP GLY GLU ALA GLU ASP GLU          
SEQRES  17 H  344  ALA LYS VAL ARG ILE ALA GLY VAL VAL THR ASN TRP THR          
SEQRES  18 H  344  LEU VAL SER MET HIS HIS ASP ASP GLN SER DHA MET ASP          
SEQRES  19 H  344  PRO ASN THR ILE ASN ALA PRO VAL ILE ILE SER THR THR          
SEQRES  20 H  344  GLY HIS ASP GLY PRO PHE GLY ALA PHE SER VAL LYS ARG          
SEQRES  21 H  344  LEU VAL SER MET LYS GLN MET GLU ARG LEU ASN GLY MET          
SEQRES  22 H  344  ARG GLY LEU ASP MET GLN SER ALA GLU ASP ALA ILE VAL          
SEQRES  23 H  344  ASN ASN THR ARG GLU ILE VAL PRO GLY LEU ILE VAL GLY          
SEQRES  24 H  344  GLY MET GLU LEU SER GLU ILE ASP GLY ALA ASN ARG MET          
SEQRES  25 H  344  GLY PRO THR PHE GLY ALA MET ALA LEU SER GLY VAL LYS          
SEQRES  26 H  344  ALA ALA HIS GLU ALA ILE ARG VAL PHE ASP LEU ARG LYS          
SEQRES  27 H  344  ALA GLN ASN ASP LYS CYS                                      
SEQRES   1 I  344  MET SER PRO SER VAL LEU GLU PRO GLN SER VAL PRO THR          
SEQRES   2 I  344  LEU VAL ASN VAL GLY LEU LYS ALA VAL GLY ARG ASN ASP          
SEQRES   3 I  344  ALA PRO VAL GLU ARG ASP ALA ARG GLY LEU SER LYS PRO          
SEQRES   4 I  344  LEU LEU GLU LEU MET PRO THR LEU GLY THR ASP ALA PHE          
SEQRES   5 I  344  THR PHE SER PRO ILE ARG GLU SER THR VAL SER ARG ALA          
SEQRES   6 I  344  MET THR ARG ARG TYR PHE ALA ASP LEU ASP ALA HIS ALA          
SEQRES   7 I  344  GLU THR ASP ILE VAL ILE VAL GLY ALA GLY SER CYS GLY          
SEQRES   8 I  344  LEU SER ALA ALA TYR VAL LEU SER THR LEU ARG PRO ASP          
SEQRES   9 I  344  LEU ARG ILE THR ILE VAL GLU ALA GLY VAL ALA PRO GLY          
SEQRES  10 I  344  GLY GLY ALA TRP LEU GLY GLY GLN LEU PHE SER ALA MET          
SEQRES  11 I  344  VAL MET ARG LYS PRO ALA ASP VAL PHE LEU ASP GLU VAL          
SEQRES  12 I  344  GLY VAL PRO TYR GLU ASP GLU GLY ASP TYR VAL VAL VAL          
SEQRES  13 I  344  LYS HIS ALA ALA LEU PHE THR SER THR VAL LEU SER LYS          
SEQRES  14 I  344  VAL LEU GLN ARG PRO ASN VAL LYS LEU PHE ASN ALA THR          
SEQRES  15 I  344  THR VAL GLU ASP LEU ILE THR ARG LYS HIS HIS ALA GLU          
SEQRES  16 I  344  SER SER SER SER SER ASP ASP GLY GLU ALA GLU ASP GLU          
SEQRES  17 I  344  ALA LYS VAL ARG ILE ALA GLY VAL VAL THR ASN TRP THR          
SEQRES  18 I  344  LEU VAL SER MET HIS HIS ASP ASP GLN SER DHA MET ASP          
SEQRES  19 I  344  PRO ASN THR ILE ASN ALA PRO VAL ILE ILE SER THR THR          
SEQRES  20 I  344  GLY HIS ASP GLY PRO PHE GLY ALA PHE SER VAL LYS ARG          
SEQRES  21 I  344  LEU VAL SER MET LYS GLN MET GLU ARG LEU ASN GLY MET          
SEQRES  22 I  344  ARG GLY LEU ASP MET GLN SER ALA GLU ASP ALA ILE VAL          
SEQRES  23 I  344  ASN ASN THR ARG GLU ILE VAL PRO GLY LEU ILE VAL GLY          
SEQRES  24 I  344  GLY MET GLU LEU SER GLU ILE ASP GLY ALA ASN ARG MET          
SEQRES  25 I  344  GLY PRO THR PHE GLY ALA MET ALA LEU SER GLY VAL LYS          
SEQRES  26 I  344  ALA ALA HIS GLU ALA ILE ARG VAL PHE ASP LEU ARG LYS          
SEQRES  27 I  344  ALA GLN ASN ASP LYS CYS                                      
SEQRES   1 J  344  MET SER PRO SER VAL LEU GLU PRO GLN SER VAL PRO THR          
SEQRES   2 J  344  LEU VAL ASN VAL GLY LEU LYS ALA VAL GLY ARG ASN ASP          
SEQRES   3 J  344  ALA PRO VAL GLU ARG ASP ALA ARG GLY LEU SER LYS PRO          
SEQRES   4 J  344  LEU LEU GLU LEU MET PRO THR LEU GLY THR ASP ALA PHE          
SEQRES   5 J  344  THR PHE SER PRO ILE ARG GLU SER THR VAL SER ARG ALA          
SEQRES   6 J  344  MET THR ARG ARG TYR PHE ALA ASP LEU ASP ALA HIS ALA          
SEQRES   7 J  344  GLU THR ASP ILE VAL ILE VAL GLY ALA GLY SER CYS GLY          
SEQRES   8 J  344  LEU SER ALA ALA TYR VAL LEU SER THR LEU ARG PRO ASP          
SEQRES   9 J  344  LEU ARG ILE THR ILE VAL GLU ALA GLY VAL ALA PRO GLY          
SEQRES  10 J  344  GLY GLY ALA TRP LEU GLY GLY GLN LEU PHE SER ALA MET          
SEQRES  11 J  344  VAL MET ARG LYS PRO ALA ASP VAL PHE LEU ASP GLU VAL          
SEQRES  12 J  344  GLY VAL PRO TYR GLU ASP GLU GLY ASP TYR VAL VAL VAL          
SEQRES  13 J  344  LYS HIS ALA ALA LEU PHE THR SER THR VAL LEU SER LYS          
SEQRES  14 J  344  VAL LEU GLN ARG PRO ASN VAL LYS LEU PHE ASN ALA THR          
SEQRES  15 J  344  THR VAL GLU ASP LEU ILE THR ARG LYS HIS HIS ALA GLU          
SEQRES  16 J  344  SER SER SER SER SER ASP ASP GLY GLU ALA GLU ASP GLU          
SEQRES  17 J  344  ALA LYS VAL ARG ILE ALA GLY VAL VAL THR ASN TRP THR          
SEQRES  18 J  344  LEU VAL SER MET HIS HIS ASP ASP GLN SER DHA MET ASP          
SEQRES  19 J  344  PRO ASN THR ILE ASN ALA PRO VAL ILE ILE SER THR THR          
SEQRES  20 J  344  GLY HIS ASP GLY PRO PHE GLY ALA PHE SER VAL LYS ARG          
SEQRES  21 J  344  LEU VAL SER MET LYS GLN MET GLU ARG LEU ASN GLY MET          
SEQRES  22 J  344  ARG GLY LEU ASP MET GLN SER ALA GLU ASP ALA ILE VAL          
SEQRES  23 J  344  ASN ASN THR ARG GLU ILE VAL PRO GLY LEU ILE VAL GLY          
SEQRES  24 J  344  GLY MET GLU LEU SER GLU ILE ASP GLY ALA ASN ARG MET          
SEQRES  25 J  344  GLY PRO THR PHE GLY ALA MET ALA LEU SER GLY VAL LYS          
SEQRES  26 J  344  ALA ALA HIS GLU ALA ILE ARG VAL PHE ASP LEU ARG LYS          
SEQRES  27 J  344  ALA GLN ASN ASP LYS CYS                                      
SEQRES   1 K  344  MET SER PRO SER VAL LEU GLU PRO GLN SER VAL PRO THR          
SEQRES   2 K  344  LEU VAL ASN VAL GLY LEU LYS ALA VAL GLY ARG ASN ASP          
SEQRES   3 K  344  ALA PRO VAL GLU ARG ASP ALA ARG GLY LEU SER LYS PRO          
SEQRES   4 K  344  LEU LEU GLU LEU MET PRO THR LEU GLY THR ASP ALA PHE          
SEQRES   5 K  344  THR PHE SER PRO ILE ARG GLU SER THR VAL SER ARG ALA          
SEQRES   6 K  344  MET THR ARG ARG TYR PHE ALA ASP LEU ASP ALA HIS ALA          
SEQRES   7 K  344  GLU THR ASP ILE VAL ILE VAL GLY ALA GLY SER CYS GLY          
SEQRES   8 K  344  LEU SER ALA ALA TYR VAL LEU SER THR LEU ARG PRO ASP          
SEQRES   9 K  344  LEU ARG ILE THR ILE VAL GLU ALA GLY VAL ALA PRO GLY          
SEQRES  10 K  344  GLY GLY ALA TRP LEU GLY GLY GLN LEU PHE SER ALA MET          
SEQRES  11 K  344  VAL MET ARG LYS PRO ALA ASP VAL PHE LEU ASP GLU VAL          
SEQRES  12 K  344  GLY VAL PRO TYR GLU ASP GLU GLY ASP TYR VAL VAL VAL          
SEQRES  13 K  344  LYS HIS ALA ALA LEU PHE THR SER THR VAL LEU SER LYS          
SEQRES  14 K  344  VAL LEU GLN ARG PRO ASN VAL LYS LEU PHE ASN ALA THR          
SEQRES  15 K  344  THR VAL GLU ASP LEU ILE THR ARG LYS HIS HIS ALA GLU          
SEQRES  16 K  344  SER SER SER SER SER ASP ASP GLY GLU ALA GLU ASP GLU          
SEQRES  17 K  344  ALA LYS VAL ARG ILE ALA GLY VAL VAL THR ASN TRP THR          
SEQRES  18 K  344  LEU VAL SER MET HIS HIS ASP ASP GLN SER DHA MET ASP          
SEQRES  19 K  344  PRO ASN THR ILE ASN ALA PRO VAL ILE ILE SER THR THR          
SEQRES  20 K  344  GLY HIS ASP GLY PRO PHE GLY ALA PHE SER VAL LYS ARG          
SEQRES  21 K  344  LEU VAL SER MET LYS GLN MET GLU ARG LEU ASN GLY MET          
SEQRES  22 K  344  ARG GLY LEU ASP MET GLN SER ALA GLU ASP ALA ILE VAL          
SEQRES  23 K  344  ASN ASN THR ARG GLU ILE VAL PRO GLY LEU ILE VAL GLY          
SEQRES  24 K  344  GLY MET GLU LEU SER GLU ILE ASP GLY ALA ASN ARG MET          
SEQRES  25 K  344  GLY PRO THR PHE GLY ALA MET ALA LEU SER GLY VAL LYS          
SEQRES  26 K  344  ALA ALA HIS GLU ALA ILE ARG VAL PHE ASP LEU ARG LYS          
SEQRES  27 K  344  ALA GLN ASN ASP LYS CYS                                      
SEQRES   1 L  344  MET SER PRO SER VAL LEU GLU PRO GLN SER VAL PRO THR          
SEQRES   2 L  344  LEU VAL ASN VAL GLY LEU LYS ALA VAL GLY ARG ASN ASP          
SEQRES   3 L  344  ALA PRO VAL GLU ARG ASP ALA ARG GLY LEU SER LYS PRO          
SEQRES   4 L  344  LEU LEU GLU LEU MET PRO THR LEU GLY THR ASP ALA PHE          
SEQRES   5 L  344  THR PHE SER PRO ILE ARG GLU SER THR VAL SER ARG ALA          
SEQRES   6 L  344  MET THR ARG ARG TYR PHE ALA ASP LEU ASP ALA HIS ALA          
SEQRES   7 L  344  GLU THR ASP ILE VAL ILE VAL GLY ALA GLY SER CYS GLY          
SEQRES   8 L  344  LEU SER ALA ALA TYR VAL LEU SER THR LEU ARG PRO ASP          
SEQRES   9 L  344  LEU ARG ILE THR ILE VAL GLU ALA GLY VAL ALA PRO GLY          
SEQRES  10 L  344  GLY GLY ALA TRP LEU GLY GLY GLN LEU PHE SER ALA MET          
SEQRES  11 L  344  VAL MET ARG LYS PRO ALA ASP VAL PHE LEU ASP GLU VAL          
SEQRES  12 L  344  GLY VAL PRO TYR GLU ASP GLU GLY ASP TYR VAL VAL VAL          
SEQRES  13 L  344  LYS HIS ALA ALA LEU PHE THR SER THR VAL LEU SER LYS          
SEQRES  14 L  344  VAL LEU GLN ARG PRO ASN VAL LYS LEU PHE ASN ALA THR          
SEQRES  15 L  344  THR VAL GLU ASP LEU ILE THR ARG LYS HIS HIS ALA GLU          
SEQRES  16 L  344  SER SER SER SER SER ASP ASP GLY GLU ALA GLU ASP GLU          
SEQRES  17 L  344  ALA LYS VAL ARG ILE ALA GLY VAL VAL THR ASN TRP THR          
SEQRES  18 L  344  LEU VAL SER MET HIS HIS ASP ASP GLN SER DHA MET ASP          
SEQRES  19 L  344  PRO ASN THR ILE ASN ALA PRO VAL ILE ILE SER THR THR          
SEQRES  20 L  344  GLY HIS ASP GLY PRO PHE GLY ALA PHE SER VAL LYS ARG          
SEQRES  21 L  344  LEU VAL SER MET LYS GLN MET GLU ARG LEU ASN GLY MET          
SEQRES  22 L  344  ARG GLY LEU ASP MET GLN SER ALA GLU ASP ALA ILE VAL          
SEQRES  23 L  344  ASN ASN THR ARG GLU ILE VAL PRO GLY LEU ILE VAL GLY          
SEQRES  24 L  344  GLY MET GLU LEU SER GLU ILE ASP GLY ALA ASN ARG MET          
SEQRES  25 L  344  GLY PRO THR PHE GLY ALA MET ALA LEU SER GLY VAL LYS          
SEQRES  26 L  344  ALA ALA HIS GLU ALA ILE ARG VAL PHE ASP LEU ARG LYS          
SEQRES  27 L  344  ALA GLN ASN ASP LYS CYS                                      
SEQRES   1 M  344  MET SER PRO SER VAL LEU GLU PRO GLN SER VAL PRO THR          
SEQRES   2 M  344  LEU VAL ASN VAL GLY LEU LYS ALA VAL GLY ARG ASN ASP          
SEQRES   3 M  344  ALA PRO VAL GLU ARG ASP ALA ARG GLY LEU SER LYS PRO          
SEQRES   4 M  344  LEU LEU GLU LEU MET PRO THR LEU GLY THR ASP ALA PHE          
SEQRES   5 M  344  THR PHE SER PRO ILE ARG GLU SER THR VAL SER ARG ALA          
SEQRES   6 M  344  MET THR ARG ARG TYR PHE ALA ASP LEU ASP ALA HIS ALA          
SEQRES   7 M  344  GLU THR ASP ILE VAL ILE VAL GLY ALA GLY SER CYS GLY          
SEQRES   8 M  344  LEU SER ALA ALA TYR VAL LEU SER THR LEU ARG PRO ASP          
SEQRES   9 M  344  LEU ARG ILE THR ILE VAL GLU ALA GLY VAL ALA PRO GLY          
SEQRES  10 M  344  GLY GLY ALA TRP LEU GLY GLY GLN LEU PHE SER ALA MET          
SEQRES  11 M  344  VAL MET ARG LYS PRO ALA ASP VAL PHE LEU ASP GLU VAL          
SEQRES  12 M  344  GLY VAL PRO TYR GLU ASP GLU GLY ASP TYR VAL VAL VAL          
SEQRES  13 M  344  LYS HIS ALA ALA LEU PHE THR SER THR VAL LEU SER LYS          
SEQRES  14 M  344  VAL LEU GLN ARG PRO ASN VAL LYS LEU PHE ASN ALA THR          
SEQRES  15 M  344  THR VAL GLU ASP LEU ILE THR ARG LYS HIS HIS ALA GLU          
SEQRES  16 M  344  SER SER SER SER SER ASP ASP GLY GLU ALA GLU ASP GLU          
SEQRES  17 M  344  ALA LYS VAL ARG ILE ALA GLY VAL VAL THR ASN TRP THR          
SEQRES  18 M  344  LEU VAL SER MET HIS HIS ASP ASP GLN SER DHA MET ASP          
SEQRES  19 M  344  PRO ASN THR ILE ASN ALA PRO VAL ILE ILE SER THR THR          
SEQRES  20 M  344  GLY HIS ASP GLY PRO PHE GLY ALA PHE SER VAL LYS ARG          
SEQRES  21 M  344  LEU VAL SER MET LYS GLN MET GLU ARG LEU ASN GLY MET          
SEQRES  22 M  344  ARG GLY LEU ASP MET GLN SER ALA GLU ASP ALA ILE VAL          
SEQRES  23 M  344  ASN ASN THR ARG GLU ILE VAL PRO GLY LEU ILE VAL GLY          
SEQRES  24 M  344  GLY MET GLU LEU SER GLU ILE ASP GLY ALA ASN ARG MET          
SEQRES  25 M  344  GLY PRO THR PHE GLY ALA MET ALA LEU SER GLY VAL LYS          
SEQRES  26 M  344  ALA ALA HIS GLU ALA ILE ARG VAL PHE ASP LEU ARG LYS          
SEQRES  27 M  344  ALA GLN ASN ASP LYS CYS                                      
SEQRES   1 N  344  MET SER PRO SER VAL LEU GLU PRO GLN SER VAL PRO THR          
SEQRES   2 N  344  LEU VAL ASN VAL GLY LEU LYS ALA VAL GLY ARG ASN ASP          
SEQRES   3 N  344  ALA PRO VAL GLU ARG ASP ALA ARG GLY LEU SER LYS PRO          
SEQRES   4 N  344  LEU LEU GLU LEU MET PRO THR LEU GLY THR ASP ALA PHE          
SEQRES   5 N  344  THR PHE SER PRO ILE ARG GLU SER THR VAL SER ARG ALA          
SEQRES   6 N  344  MET THR ARG ARG TYR PHE ALA ASP LEU ASP ALA HIS ALA          
SEQRES   7 N  344  GLU THR ASP ILE VAL ILE VAL GLY ALA GLY SER CYS GLY          
SEQRES   8 N  344  LEU SER ALA ALA TYR VAL LEU SER THR LEU ARG PRO ASP          
SEQRES   9 N  344  LEU ARG ILE THR ILE VAL GLU ALA GLY VAL ALA PRO GLY          
SEQRES  10 N  344  GLY GLY ALA TRP LEU GLY GLY GLN LEU PHE SER ALA MET          
SEQRES  11 N  344  VAL MET ARG LYS PRO ALA ASP VAL PHE LEU ASP GLU VAL          
SEQRES  12 N  344  GLY VAL PRO TYR GLU ASP GLU GLY ASP TYR VAL VAL VAL          
SEQRES  13 N  344  LYS HIS ALA ALA LEU PHE THR SER THR VAL LEU SER LYS          
SEQRES  14 N  344  VAL LEU GLN ARG PRO ASN VAL LYS LEU PHE ASN ALA THR          
SEQRES  15 N  344  THR VAL GLU ASP LEU ILE THR ARG LYS HIS HIS ALA GLU          
SEQRES  16 N  344  SER SER SER SER SER ASP ASP GLY GLU ALA GLU ASP GLU          
SEQRES  17 N  344  ALA LYS VAL ARG ILE ALA GLY VAL VAL THR ASN TRP THR          
SEQRES  18 N  344  LEU VAL SER MET HIS HIS ASP ASP GLN SER DHA MET ASP          
SEQRES  19 N  344  PRO ASN THR ILE ASN ALA PRO VAL ILE ILE SER THR THR          
SEQRES  20 N  344  GLY HIS ASP GLY PRO PHE GLY ALA PHE SER VAL LYS ARG          
SEQRES  21 N  344  LEU VAL SER MET LYS GLN MET GLU ARG LEU ASN GLY MET          
SEQRES  22 N  344  ARG GLY LEU ASP MET GLN SER ALA GLU ASP ALA ILE VAL          
SEQRES  23 N  344  ASN ASN THR ARG GLU ILE VAL PRO GLY LEU ILE VAL GLY          
SEQRES  24 N  344  GLY MET GLU LEU SER GLU ILE ASP GLY ALA ASN ARG MET          
SEQRES  25 N  344  GLY PRO THR PHE GLY ALA MET ALA LEU SER GLY VAL LYS          
SEQRES  26 N  344  ALA ALA HIS GLU ALA ILE ARG VAL PHE ASP LEU ARG LYS          
SEQRES  27 N  344  ALA GLN ASN ASP LYS CYS                                      
SEQRES   1 O  344  MET SER PRO SER VAL LEU GLU PRO GLN SER VAL PRO THR          
SEQRES   2 O  344  LEU VAL ASN VAL GLY LEU LYS ALA VAL GLY ARG ASN ASP          
SEQRES   3 O  344  ALA PRO VAL GLU ARG ASP ALA ARG GLY LEU SER LYS PRO          
SEQRES   4 O  344  LEU LEU GLU LEU MET PRO THR LEU GLY THR ASP ALA PHE          
SEQRES   5 O  344  THR PHE SER PRO ILE ARG GLU SER THR VAL SER ARG ALA          
SEQRES   6 O  344  MET THR ARG ARG TYR PHE ALA ASP LEU ASP ALA HIS ALA          
SEQRES   7 O  344  GLU THR ASP ILE VAL ILE VAL GLY ALA GLY SER CYS GLY          
SEQRES   8 O  344  LEU SER ALA ALA TYR VAL LEU SER THR LEU ARG PRO ASP          
SEQRES   9 O  344  LEU ARG ILE THR ILE VAL GLU ALA GLY VAL ALA PRO GLY          
SEQRES  10 O  344  GLY GLY ALA TRP LEU GLY GLY GLN LEU PHE SER ALA MET          
SEQRES  11 O  344  VAL MET ARG LYS PRO ALA ASP VAL PHE LEU ASP GLU VAL          
SEQRES  12 O  344  GLY VAL PRO TYR GLU ASP GLU GLY ASP TYR VAL VAL VAL          
SEQRES  13 O  344  LYS HIS ALA ALA LEU PHE THR SER THR VAL LEU SER LYS          
SEQRES  14 O  344  VAL LEU GLN ARG PRO ASN VAL LYS LEU PHE ASN ALA THR          
SEQRES  15 O  344  THR VAL GLU ASP LEU ILE THR ARG LYS HIS HIS ALA GLU          
SEQRES  16 O  344  SER SER SER SER SER ASP ASP GLY GLU ALA GLU ASP GLU          
SEQRES  17 O  344  ALA LYS VAL ARG ILE ALA GLY VAL VAL THR ASN TRP THR          
SEQRES  18 O  344  LEU VAL SER MET HIS HIS ASP ASP GLN SER DHA MET ASP          
SEQRES  19 O  344  PRO ASN THR ILE ASN ALA PRO VAL ILE ILE SER THR THR          
SEQRES  20 O  344  GLY HIS ASP GLY PRO PHE GLY ALA PHE SER VAL LYS ARG          
SEQRES  21 O  344  LEU VAL SER MET LYS GLN MET GLU ARG LEU ASN GLY MET          
SEQRES  22 O  344  ARG GLY LEU ASP MET GLN SER ALA GLU ASP ALA ILE VAL          
SEQRES  23 O  344  ASN ASN THR ARG GLU ILE VAL PRO GLY LEU ILE VAL GLY          
SEQRES  24 O  344  GLY MET GLU LEU SER GLU ILE ASP GLY ALA ASN ARG MET          
SEQRES  25 O  344  GLY PRO THR PHE GLY ALA MET ALA LEU SER GLY VAL LYS          
SEQRES  26 O  344  ALA ALA HIS GLU ALA ILE ARG VAL PHE ASP LEU ARG LYS          
SEQRES  27 O  344  ALA GLN ASN ASP LYS CYS                                      
SEQRES   1 P  344  MET SER PRO SER VAL LEU GLU PRO GLN SER VAL PRO THR          
SEQRES   2 P  344  LEU VAL ASN VAL GLY LEU LYS ALA VAL GLY ARG ASN ASP          
SEQRES   3 P  344  ALA PRO VAL GLU ARG ASP ALA ARG GLY LEU SER LYS PRO          
SEQRES   4 P  344  LEU LEU GLU LEU MET PRO THR LEU GLY THR ASP ALA PHE          
SEQRES   5 P  344  THR PHE SER PRO ILE ARG GLU SER THR VAL SER ARG ALA          
SEQRES   6 P  344  MET THR ARG ARG TYR PHE ALA ASP LEU ASP ALA HIS ALA          
SEQRES   7 P  344  GLU THR ASP ILE VAL ILE VAL GLY ALA GLY SER CYS GLY          
SEQRES   8 P  344  LEU SER ALA ALA TYR VAL LEU SER THR LEU ARG PRO ASP          
SEQRES   9 P  344  LEU ARG ILE THR ILE VAL GLU ALA GLY VAL ALA PRO GLY          
SEQRES  10 P  344  GLY GLY ALA TRP LEU GLY GLY GLN LEU PHE SER ALA MET          
SEQRES  11 P  344  VAL MET ARG LYS PRO ALA ASP VAL PHE LEU ASP GLU VAL          
SEQRES  12 P  344  GLY VAL PRO TYR GLU ASP GLU GLY ASP TYR VAL VAL VAL          
SEQRES  13 P  344  LYS HIS ALA ALA LEU PHE THR SER THR VAL LEU SER LYS          
SEQRES  14 P  344  VAL LEU GLN ARG PRO ASN VAL LYS LEU PHE ASN ALA THR          
SEQRES  15 P  344  THR VAL GLU ASP LEU ILE THR ARG LYS HIS HIS ALA GLU          
SEQRES  16 P  344  SER SER SER SER SER ASP ASP GLY GLU ALA GLU ASP GLU          
SEQRES  17 P  344  ALA LYS VAL ARG ILE ALA GLY VAL VAL THR ASN TRP THR          
SEQRES  18 P  344  LEU VAL SER MET HIS HIS ASP ASP GLN SER DHA MET ASP          
SEQRES  19 P  344  PRO ASN THR ILE ASN ALA PRO VAL ILE ILE SER THR THR          
SEQRES  20 P  344  GLY HIS ASP GLY PRO PHE GLY ALA PHE SER VAL LYS ARG          
SEQRES  21 P  344  LEU VAL SER MET LYS GLN MET GLU ARG LEU ASN GLY MET          
SEQRES  22 P  344  ARG GLY LEU ASP MET GLN SER ALA GLU ASP ALA ILE VAL          
SEQRES  23 P  344  ASN ASN THR ARG GLU ILE VAL PRO GLY LEU ILE VAL GLY          
SEQRES  24 P  344  GLY MET GLU LEU SER GLU ILE ASP GLY ALA ASN ARG MET          
SEQRES  25 P  344  GLY PRO THR PHE GLY ALA MET ALA LEU SER GLY VAL LYS          
SEQRES  26 P  344  ALA ALA HIS GLU ALA ILE ARG VAL PHE ASP LEU ARG LYS          
SEQRES  27 P  344  ALA GLN ASN ASP LYS CYS                                      
MODRES 3JSK DHA A  232  ALA  2-AMINO-ACRYLIC ACID                               
MODRES 3JSK DHA B  232  ALA  2-AMINO-ACRYLIC ACID                               
MODRES 3JSK DHA C  232  ALA  2-AMINO-ACRYLIC ACID                               
MODRES 3JSK DHA D  232  ALA  2-AMINO-ACRYLIC ACID                               
MODRES 3JSK DHA E  232  ALA  2-AMINO-ACRYLIC ACID                               
MODRES 3JSK DHA F  232  ALA  2-AMINO-ACRYLIC ACID                               
MODRES 3JSK DHA G  232  ALA  2-AMINO-ACRYLIC ACID                               
MODRES 3JSK DHA H  232  ALA  2-AMINO-ACRYLIC ACID                               
MODRES 3JSK DHA I  232  ALA  2-AMINO-ACRYLIC ACID                               
MODRES 3JSK DHA J  232  ALA  2-AMINO-ACRYLIC ACID                               
MODRES 3JSK DHA K  232  ALA  2-AMINO-ACRYLIC ACID                               
MODRES 3JSK DHA L  232  ALA  2-AMINO-ACRYLIC ACID                               
MODRES 3JSK DHA M  232  ALA  2-AMINO-ACRYLIC ACID                               
MODRES 3JSK DHA N  232  ALA  2-AMINO-ACRYLIC ACID                               
MODRES 3JSK DHA O  232  ALA  2-AMINO-ACRYLIC ACID                               
MODRES 3JSK DHA P  232  ALA  2-AMINO-ACRYLIC ACID                               
HET    DHA  A 232       5                                                       
HET    DHA  B 232       5                                                       
HET    DHA  C 232       5                                                       
HET    DHA  D 232       5                                                       
HET    DHA  E 232       5                                                       
HET    DHA  F 232       5                                                       
HET    DHA  G 232       5                                                       
HET    DHA  H 232       5                                                       
HET    DHA  I 232       5                                                       
HET    DHA  J 232       5                                                       
HET    DHA  K 232       5                                                       
HET    DHA  L 232       5                                                       
HET    DHA  M 232       5                                                       
HET    DHA  N 232       5                                                       
HET    DHA  O 232       5                                                       
HET    DHA  P 232       5                                                       
HET    AHZ  A 500      38                                                       
HET    FE2  A 345       1                                                       
HET    AHZ  B 500      38                                                       
HET    FE2  B 345       1                                                       
HET    AHZ  C 500      38                                                       
HET    FE2  C 345       1                                                       
HET    AHZ  D 500      38                                                       
HET    FE2  D 345       1                                                       
HET    AHZ  E 500      38                                                       
HET    FE2  E 345       1                                                       
HET    AHZ  F 500      38                                                       
HET    FE2  F 345       1                                                       
HET    AHZ  G 500      38                                                       
HET    FE2  G 345       1                                                       
HET    AHZ  H 500      38                                                       
HET    FE2  H 345       1                                                       
HET    AHZ  I 500      38                                                       
HET    FE2  I 345       1                                                       
HET    AHZ  J 500      38                                                       
HET    FE2  J 345       1                                                       
HET    AHZ  K 500      38                                                       
HET    FE2  K 345       1                                                       
HET    FE2  K 346       1                                                       
HET    AHZ  L 500      38                                                       
HET    FE2  L 345       1                                                       
HET    AHZ  M 500      38                                                       
HET    FE2  M 345       1                                                       
HET    FE2  M 346       1                                                       
HET    AHZ  N 500      38                                                       
HET    FE2  N 345       1                                                       
HET    AHZ  O 500      38                                                       
HET    AHZ  P 500      38                                                       
HETNAM     DHA 2-AMINO-ACRYLIC ACID                                             
HETNAM     AHZ ADENOSINE DIPHOSPHATE 5-(BETA-ETHYL)-4-METHYL-THIAZOLE-          
HETNAM   2 AHZ  2-CARBOXYLIC ACID                                               
HETNAM     FE2 FE (II) ION                                                      
HETSYN     DHA 2,3-DIDEHYDROALANINE                                             
FORMUL   1  DHA    16(C3 H5 N O2)                                               
FORMUL  17  AHZ    16(C17 H19 N6 O12 P2 S 3-)                                   
FORMUL  18  FE2    16(FE 2+)                                                    
FORMUL  49  HOH   *391(H2 O)                                                    
HELIX    1   1 SER A   37  MET A   44  1                                   8    
HELIX    2   2 PRO A   45  LEU A   47  5                                   3    
HELIX    3   3 ARG A   58  GLU A   79  1                                  22    
HELIX    4   4 GLY A   88  ARG A  102  1                                  15    
HELIX    5   5 ALA A  136  GLY A  144  1                                   9    
HELIX    6   6 HIS A  158  GLN A  172  1                                  15    
HELIX    7   7 THR A  221  MET A  225  1                                   5    
HELIX    8   8 ALA A  255  MET A  264  1                                  10    
HELIX    9   9 ASP A  277  ASN A  288  1                                  12    
HELIX   10  10 GLU A  302  GLY A  308  1                                   7    
HELIX   11  11 PHE A  316  ASP A  342  1                                  27    
HELIX   12  12 SER B   37  MET B   44  1                                   8    
HELIX   13  13 PRO B   45  LEU B   47  5                                   3    
HELIX   14  14 ARG B   58  HIS B   77  1                                  20    
HELIX   15  15 GLY B   88  ARG B  102  1                                  15    
HELIX   16  16 ALA B  136  VAL B  143  1                                   8    
HELIX   17  17 HIS B  158  ARG B  173  1                                  16    
HELIX   18  18 THR B  221  MET B  225  1                                   5    
HELIX   19  19 ALA B  255  MET B  264  1                                  10    
HELIX   20  20 ASP B  277  THR B  289  1                                  13    
HELIX   21  21 GLY B  299  GLY B  308  1                                  10    
HELIX   22  22 PHE B  316  ASP B  342  1                                  27    
HELIX   23  23 SER C   37  MET C   44  1                                   8    
HELIX   24  24 PRO C   45  LEU C   47  5                                   3    
HELIX   25  25 ARG C   58  HIS C   77  1                                  20    
HELIX   26  26 GLY C   88  ARG C  102  1                                  15    
HELIX   27  27 ALA C  136  GLY C  144  1                                   9    
HELIX   28  28 HIS C  158  LEU C  171  1                                  14    
HELIX   29  29 THR C  221  MET C  225  1                                   5    
HELIX   30  30 ALA C  255  MET C  264  1                                  10    
HELIX   31  31 ASP C  277  THR C  289  1                                  13    
HELIX   32  32 GLY C  300  GLY C  308  1                                   9    
HELIX   33  33 PHE C  316  ASP C  342  1                                  27    
HELIX   34  34 SER D   37  MET D   44  1                                   8    
HELIX   35  35 PRO D   45  LEU D   47  5                                   3    
HELIX   36  36 ARG D   58  ALA D   78  1                                  21    
HELIX   37  37 GLY D   88  ARG D  102  1                                  15    
HELIX   38  38 ALA D  136  VAL D  143  1                                   8    
HELIX   39  39 HIS D  158  ARG D  173  1                                  16    
HELIX   40  40 THR D  221  MET D  225  1                                   5    
HELIX   41  41 ALA D  255  MET D  264  1                                  10    
HELIX   42  42 ASP D  277  ASN D  288  1                                  12    
HELIX   43  43 MET D  301  GLY D  308  1                                   8    
HELIX   44  44 PHE D  316  ASP D  342  1                                  27    
HELIX   45  45 SER E   37  MET E   44  1                                   8    
HELIX   46  46 PRO E   45  LEU E   47  5                                   3    
HELIX   47  47 ARG E   58  HIS E   77  1                                  20    
HELIX   48  48 GLY E   88  ARG E  102  1                                  15    
HELIX   49  49 ALA E  136  GLY E  144  1                                   9    
HELIX   50  50 HIS E  158  ARG E  173  1                                  16    
HELIX   51  51 THR E  221  MET E  225  1                                   5    
HELIX   52  52 ALA E  255  MET E  264  1                                  10    
HELIX   53  53 ASP E  277  THR E  289  1                                  13    
HELIX   54  54 GLY E  299  GLY E  308  1                                  10    
HELIX   55  55 PHE E  316  ASP E  342  1                                  27    
HELIX   56  56 SER F   37  MET F   44  1                                   8    
HELIX   57  57 PRO F   45  LEU F   47  5                                   3    
HELIX   58  58 ARG F   58  ALA F   78  1                                  21    
HELIX   59  59 GLY F   88  ARG F  102  1                                  15    
HELIX   60  60 ALA F  136  VAL F  143  1                                   8    
HELIX   61  61 HIS F  158  ARG F  173  1                                  16    
HELIX   62  62 THR F  221  MET F  225  1                                   5    
HELIX   63  63 ALA F  255  MET F  264  1                                  10    
HELIX   64  64 ASP F  277  ASN F  288  1                                  12    
HELIX   65  65 MET F  301  GLY F  308  1                                   8    
HELIX   66  66 PHE F  316  ASP F  342  1                                  27    
HELIX   67  67 SER G   37  MET G   44  1                                   8    
HELIX   68  68 PRO G   45  LEU G   47  5                                   3    
HELIX   69  69 ARG G   58  ALA G   78  1                                  21    
HELIX   70  70 GLY G   88  ARG G  102  1                                  15    
HELIX   71  71 ALA G  136  GLY G  144  1                                   9    
HELIX   72  72 HIS G  158  ARG G  173  1                                  16    
HELIX   73  73 THR G  221  MET G  225  1                                   5    
HELIX   74  74 ALA G  255  MET G  264  1                                  10    
HELIX   75  75 ASP G  277  ASN G  288  1                                  12    
HELIX   76  76 GLU G  302  GLY G  308  1                                   7    
HELIX   77  77 PHE G  316  ASP G  342  1                                  27    
HELIX   78  78 SER H   37  MET H   44  1                                   8    
HELIX   79  79 PRO H   45  LEU H   47  5                                   3    
HELIX   80  80 ARG H   58  HIS H   77  1                                  20    
HELIX   81  81 GLY H   88  ARG H  102  1                                  15    
HELIX   82  82 ALA H  136  VAL H  143  1                                   8    
HELIX   83  83 HIS H  158  ARG H  173  1                                  16    
HELIX   84  84 THR H  221  MET H  225  1                                   5    
HELIX   85  85 ALA H  255  MET H  264  1                                  10    
HELIX   86  86 ASP H  277  ASN H  288  1                                  12    
HELIX   87  87 MET H  301  GLY H  308  1                                   8    
HELIX   88  88 PHE H  316  ASN H  341  1                                  26    
HELIX   89  89 SER I   37  MET I   44  1                                   8    
HELIX   90  90 PRO I   45  LEU I   47  5                                   3    
HELIX   91  91 ARG I   58  HIS I   77  1                                  20    
HELIX   92  92 GLY I   88  ARG I  102  1                                  15    
HELIX   93  93 ALA I  136  VAL I  143  1                                   8    
HELIX   94  94 HIS I  158  ARG I  173  1                                  16    
HELIX   95  95 TRP I  220  MET I  225  1                                   6    
HELIX   96  96 ALA I  255  MET I  264  1                                  10    
HELIX   97  97 ASP I  277  ASN I  288  1                                  12    
HELIX   98  98 MET I  301  GLY I  308  1                                   8    
HELIX   99  99 PHE I  316  ASP I  342  1                                  27    
HELIX  100 100 SER J   37  MET J   44  1                                   8    
HELIX  101 101 PRO J   45  LEU J   47  5                                   3    
HELIX  102 102 ARG J   58  ALA J   78  1                                  21    
HELIX  103 103 GLY J   88  ARG J  102  1                                  15    
HELIX  104 104 PRO J  135  GLY J  144  1                                  10    
HELIX  105 105 HIS J  158  ARG J  173  1                                  16    
HELIX  106 106 THR J  221  MET J  225  1                                   5    
HELIX  107 107 ALA J  255  MET J  264  1                                  10    
HELIX  108 108 ASP J  277  ASN J  288  1                                  12    
HELIX  109 109 GLY J  300  GLY J  308  1                                   9    
HELIX  110 110 PHE J  316  ASP J  342  1                                  27    
HELIX  111 111 SER K   37  MET K   44  1                                   8    
HELIX  112 112 PRO K   45  LEU K   47  5                                   3    
HELIX  113 113 ARG K   58  ALA K   78  1                                  21    
HELIX  114 114 GLY K   88  ARG K  102  1                                  15    
HELIX  115 115 ALA K  136  GLY K  144  1                                   9    
HELIX  116 116 HIS K  158  ARG K  173  1                                  16    
HELIX  117 117 THR K  221  MET K  225  1                                   5    
HELIX  118 118 ALA K  255  MET K  264  1                                  10    
HELIX  119 119 ASP K  277  ASN K  288  1                                  12    
HELIX  120 120 MET K  301  GLY K  308  1                                   8    
HELIX  121 121 PHE K  316  ASP K  342  1                                  27    
HELIX  122 122 SER L   37  MET L   44  1                                   8    
HELIX  123 123 PRO L   45  LEU L   47  5                                   3    
HELIX  124 124 ARG L   58  ALA L   78  1                                  21    
HELIX  125 125 GLY L   88  ARG L  102  1                                  15    
HELIX  126 126 ALA L  136  GLY L  144  1                                   9    
HELIX  127 127 HIS L  158  ARG L  173  1                                  16    
HELIX  128 128 THR L  221  MET L  225  1                                   5    
HELIX  129 129 ALA L  255  MET L  264  1                                  10    
HELIX  130 130 ASP L  277  ASN L  288  1                                  12    
HELIX  131 131 MET L  301  GLY L  308  1                                   8    
HELIX  132 132 PHE L  316  ASN L  341  1                                  26    
HELIX  133 133 SER M   37  MET M   44  1                                   8    
HELIX  134 134 PRO M   45  LEU M   47  5                                   3    
HELIX  135 135 ARG M   58  ALA M   78  1                                  21    
HELIX  136 136 GLY M   88  ARG M  102  1                                  15    
HELIX  137 137 GLY M  117  TRP M  121  5                                   5    
HELIX  138 138 ALA M  136  GLY M  144  1                                   9    
HELIX  139 139 HIS M  158  ARG M  173  1                                  16    
HELIX  140 140 THR M  221  MET M  225  1                                   5    
HELIX  141 141 ALA M  255  MET M  264  1                                  10    
HELIX  142 142 ASP M  277  ASN M  288  1                                  12    
HELIX  143 143 GLY M  299  GLY M  308  1                                  10    
HELIX  144 144 PHE M  316  ASP M  342  1                                  27    
HELIX  145 145 SER N   37  MET N   44  1                                   8    
HELIX  146 146 PRO N   45  LEU N   47  5                                   3    
HELIX  147 147 ARG N   58  ALA N   78  1                                  21    
HELIX  148 148 GLY N   88  ARG N  102  1                                  15    
HELIX  149 149 ALA N  136  GLY N  144  1                                   9    
HELIX  150 150 HIS N  158  ARG N  173  1                                  16    
HELIX  151 151 THR N  221  MET N  225  1                                   5    
HELIX  152 152 ALA N  255  MET N  264  1                                  10    
HELIX  153 153 ASP N  277  ASN N  288  1                                  12    
HELIX  154 154 GLY N  300  GLY N  308  1                                   9    
HELIX  155 155 PHE N  316  ASP N  342  1                                  27    
HELIX  156 156 SER O   37  MET O   44  1                                   8    
HELIX  157 157 PRO O   45  LEU O   47  5                                   3    
HELIX  158 158 ARG O   58  ALA O   78  1                                  21    
HELIX  159 159 GLY O   88  ARG O  102  1                                  15    
HELIX  160 160 ALA O  136  VAL O  143  1                                   8    
HELIX  161 161 HIS O  158  ARG O  173  1                                  16    
HELIX  162 162 THR O  221  MET O  225  1                                   5    
HELIX  163 163 ALA O  255  MET O  264  1                                  10    
HELIX  164 164 ASP O  277  ASN O  288  1                                  12    
HELIX  165 165 GLU O  302  GLY O  308  1                                   7    
HELIX  166 166 PHE O  316  ASN O  341  1                                  26    
HELIX  167 167 SER P   37  GLU P   42  1                                   6    
HELIX  168 168 LEU P   43  LEU P   47  5                                   5    
HELIX  169 169 ARG P   58  ALA P   78  1                                  21    
HELIX  170 170 GLY P   88  ARG P  102  1                                  15    
HELIX  171 171 ALA P  136  GLY P  144  1                                   9    
HELIX  172 172 HIS P  158  ARG P  173  1                                  16    
HELIX  173 173 THR P  221  MET P  225  1                                   5    
HELIX  174 174 ALA P  255  MET P  264  1                                  10    
HELIX  175 175 ASP P  277  ASN P  288  1                                  12    
HELIX  176 176 MET P  301  GLY P  308  1                                   8    
HELIX  177 177 PHE P  316  ASP P  342  1                                  27    
SHEET    1   A 6 VAL A 176  ASN A 180  0                                        
SHEET    2   A 6 ILE A 107  GLU A 111  1  N  ILE A 109   O  PHE A 179           
SHEET    3   A 6 ILE A  82  VAL A  85  1  N  ILE A  84   O  VAL A 110           
SHEET    4   A 6 VAL A 242  SER A 245  1  O  ILE A 244   N  VAL A  83           
SHEET    5   A 6 LEU A 296  VAL A 298  1  O  ILE A 297   N  ILE A 243           
SHEET    6   A 6 ARG A 290  VAL A 293 -1  N  VAL A 293   O  LEU A 296           
SHEET    1   B 3 MET A 130  ARG A 133  0                                        
SHEET    2   B 3 TYR A 153  VAL A 156 -1  O  VAL A 156   N  MET A 130           
SHEET    3   B 3 GLU A 148  ASP A 149 -1  N  GLU A 148   O  VAL A 155           
SHEET    1   C 3 THR A 182  LYS A 191  0                                        
SHEET    2   C 3 VAL A 211  TRP A 220 -1  O  VAL A 217   N  ASP A 186           
SHEET    3   C 3 ASN A 236  ASN A 239 -1  O  ASN A 236   N  THR A 218           
SHEET    1   D 2 ARG A 274  LEU A 276  0                                        
SHEET    2   D 2 ASN A 310  ARG A 311  1  O  ARG A 311   N  GLY A 275           
SHEET    1   E 6 VAL B 176  ASN B 180  0                                        
SHEET    2   E 6 ILE B 107  GLU B 111  1  N  ILE B 109   O  PHE B 179           
SHEET    3   E 6 ILE B  82  VAL B  85  1  N  ILE B  82   O  THR B 108           
SHEET    4   E 6 VAL B 242  SER B 245  1  O  ILE B 244   N  VAL B  83           
SHEET    5   E 6 LEU B 296  VAL B 298  1  O  ILE B 297   N  ILE B 243           
SHEET    6   E 6 ARG B 290  VAL B 293 -1  N  VAL B 293   O  LEU B 296           
SHEET    1   F 3 MET B 130  ARG B 133  0                                        
SHEET    2   F 3 TYR B 153  VAL B 156 -1  O  VAL B 154   N  MET B 132           
SHEET    3   F 3 GLU B 148  ASP B 149 -1  N  GLU B 148   O  VAL B 155           
SHEET    1   G 3 THR B 182  ARG B 190  0                                        
SHEET    2   G 3 ARG B 212  TRP B 220 -1  O  ALA B 214   N  ILE B 188           
SHEET    3   G 3 ASN B 236  ASN B 239 -1  O  ASN B 236   N  THR B 218           
SHEET    1   H 6 VAL C 176  ASN C 180  0                                        
SHEET    2   H 6 ILE C 107  GLU C 111  1  N  ILE C 109   O  PHE C 179           
SHEET    3   H 6 ILE C  82  VAL C  85  1  N  ILE C  82   O  THR C 108           
SHEET    4   H 6 VAL C 242  SER C 245  1  O  ILE C 244   N  VAL C  83           
SHEET    5   H 6 LEU C 296  VAL C 298  1  O  ILE C 297   N  SER C 245           
SHEET    6   H 6 ARG C 290  VAL C 293 -1  N  VAL C 293   O  LEU C 296           
SHEET    1   I 3 MET C 130  ARG C 133  0                                        
SHEET    2   I 3 TYR C 153  VAL C 156 -1  O  VAL C 156   N  MET C 130           
SHEET    3   I 3 GLU C 148  ASP C 149 -1  N  GLU C 148   O  VAL C 155           
SHEET    1   J 3 THR C 182  LYS C 191  0                                        
SHEET    2   J 3 VAL C 211  TRP C 220 -1  O  ALA C 214   N  ILE C 188           
SHEET    3   J 3 ASN C 236  ASN C 239 -1  O  ASN C 236   N  THR C 218           
SHEET    1   K 6 VAL D 176  ASN D 180  0                                        
SHEET    2   K 6 ILE D 107  GLU D 111  1  N  ILE D 109   O  PHE D 179           
SHEET    3   K 6 ILE D  82  VAL D  85  1  N  ILE D  84   O  THR D 108           
SHEET    4   K 6 VAL D 242  SER D 245  1  O  ILE D 244   N  VAL D  83           
SHEET    5   K 6 LEU D 296  VAL D 298  1  O  ILE D 297   N  SER D 245           
SHEET    6   K 6 ARG D 290  VAL D 293 -1  N  VAL D 293   O  LEU D 296           
SHEET    1   L 3 MET D 130  ARG D 133  0                                        
SHEET    2   L 3 TYR D 153  VAL D 156 -1  O  VAL D 156   N  MET D 130           
SHEET    3   L 3 GLU D 148  ASP D 149 -1  N  GLU D 148   O  VAL D 155           
SHEET    1   M 3 THR D 182  LYS D 191  0                                        
SHEET    2   M 3 VAL D 211  TRP D 220 -1  O  ALA D 214   N  ILE D 188           
SHEET    3   M 3 ASN D 236  ASN D 239 -1  O  ASN D 236   N  THR D 218           
SHEET    1   N 2 ARG D 274  LEU D 276  0                                        
SHEET    2   N 2 ASN D 310  ARG D 311  1  O  ARG D 311   N  GLY D 275           
SHEET    1   O 6 VAL E 176  ASN E 180  0                                        
SHEET    2   O 6 ILE E 107  GLU E 111  1  N  ILE E 109   O  PHE E 179           
SHEET    3   O 6 ILE E  82  VAL E  85  1  N  ILE E  82   O  THR E 108           
SHEET    4   O 6 VAL E 242  SER E 245  1  O  ILE E 244   N  VAL E  83           
SHEET    5   O 6 LEU E 296  VAL E 298  1  O  ILE E 297   N  SER E 245           
SHEET    6   O 6 ARG E 290  VAL E 293 -1  N  VAL E 293   O  LEU E 296           
SHEET    1   P 3 MET E 130  ARG E 133  0                                        
SHEET    2   P 3 TYR E 153  VAL E 156 -1  O  VAL E 154   N  MET E 132           
SHEET    3   P 3 GLU E 148  ASP E 149 -1  N  GLU E 148   O  VAL E 155           
SHEET    1   Q 3 THR E 182  ARG E 190  0                                        
SHEET    2   Q 3 ARG E 212  TRP E 220 -1  O  GLY E 215   N  ILE E 188           
SHEET    3   Q 3 ASN E 236  ASN E 239 -1  O  ASN E 236   N  THR E 218           
SHEET    1   R 6 VAL F 176  ASN F 180  0                                        
SHEET    2   R 6 ILE F 107  GLU F 111  1  N  ILE F 109   O  PHE F 179           
SHEET    3   R 6 ILE F  82  VAL F  85  1  N  ILE F  82   O  THR F 108           
SHEET    4   R 6 VAL F 242  SER F 245  1  O  ILE F 244   N  VAL F  83           
SHEET    5   R 6 LEU F 296  VAL F 298  1  O  ILE F 297   N  SER F 245           
SHEET    6   R 6 ARG F 290  VAL F 293 -1  N  VAL F 293   O  LEU F 296           
SHEET    1   S 3 MET F 130  ARG F 133  0                                        
SHEET    2   S 3 TYR F 153  VAL F 156 -1  O  VAL F 154   N  MET F 132           
SHEET    3   S 3 GLU F 148  ASP F 149 -1  N  GLU F 148   O  VAL F 155           
SHEET    1   T 3 THR F 182  LYS F 191  0                                        
SHEET    2   T 3 VAL F 211  TRP F 220 -1  O  GLY F 215   N  ILE F 188           
SHEET    3   T 3 ASN F 236  ASN F 239 -1  O  ASN F 236   N  THR F 218           
SHEET    1   U 6 VAL G 176  PHE G 179  0                                        
SHEET    2   U 6 ILE G 107  VAL G 110  1  N  ILE G 109   O  PHE G 179           
SHEET    3   U 6 ILE G  82  VAL G  85  1  N  ILE G  82   O  THR G 108           
SHEET    4   U 6 VAL G 242  SER G 245  1  O  ILE G 244   N  VAL G  83           
SHEET    5   U 6 LEU G 296  VAL G 298  1  O  ILE G 297   N  ILE G 243           
SHEET    6   U 6 ARG G 290  VAL G 293 -1  N  VAL G 293   O  LEU G 296           
SHEET    1   V 3 MET G 130  ARG G 133  0                                        
SHEET    2   V 3 TYR G 153  VAL G 156 -1  O  VAL G 154   N  MET G 132           
SHEET    3   V 3 GLU G 148  ASP G 149 -1  N  GLU G 148   O  VAL G 155           
SHEET    1   W 3 THR G 182  ARG G 190  0                                        
SHEET    2   W 3 ARG G 212  TRP G 220 -1  O  VAL G 217   N  ASP G 186           
SHEET    3   W 3 ASN G 236  ASN G 239 -1  O  ASN G 236   N  THR G 218           
SHEET    1   X 6 VAL H 176  ASN H 180  0                                        
SHEET    2   X 6 ILE H 107  GLU H 111  1  N  ILE H 109   O  PHE H 179           
SHEET    3   X 6 ILE H  82  VAL H  85  1  N  ILE H  82   O  THR H 108           
SHEET    4   X 6 VAL H 242  SER H 245  1  O  ILE H 244   N  VAL H  85           
SHEET    5   X 6 LEU H 296  VAL H 298  1  O  ILE H 297   N  ILE H 243           
SHEET    6   X 6 ARG H 290  VAL H 293 -1  N  VAL H 293   O  LEU H 296           
SHEET    1   Y 3 MET H 130  ARG H 133  0                                        
SHEET    2   Y 3 TYR H 153  VAL H 156 -1  O  VAL H 154   N  MET H 132           
SHEET    3   Y 3 GLU H 148  ASP H 149 -1  N  GLU H 148   O  VAL H 155           
SHEET    1   Z 3 THR H 182  ARG H 190  0                                        
SHEET    2   Z 3 ARG H 212  TRP H 220 -1  O  ALA H 214   N  ILE H 188           
SHEET    3   Z 3 ASN H 236  ASN H 239 -1  O  ASN H 236   N  THR H 218           
SHEET    1  AA 6 VAL I 176  ASN I 180  0                                        
SHEET    2  AA 6 ILE I 107  GLU I 111  1  N  ILE I 109   O  PHE I 179           
SHEET    3  AA 6 ILE I  82  VAL I  85  1  N  ILE I  82   O  THR I 108           
SHEET    4  AA 6 VAL I 242  SER I 245  1  O  ILE I 244   N  VAL I  83           
SHEET    5  AA 6 LEU I 296  VAL I 298  1  O  ILE I 297   N  ILE I 243           
SHEET    6  AA 6 ARG I 290  VAL I 293 -1  N  VAL I 293   O  LEU I 296           
SHEET    1  AB 3 MET I 130  ARG I 133  0                                        
SHEET    2  AB 3 TYR I 153  VAL I 156 -1  O  VAL I 156   N  MET I 130           
SHEET    3  AB 3 GLU I 148  ASP I 149 -1  N  GLU I 148   O  VAL I 155           
SHEET    1  AC 3 ASP I 186  ARG I 190  0                                        
SHEET    2  AC 3 ARG I 212  THR I 218 -1  O  VAL I 217   N  ASP I 186           
SHEET    3  AC 3 ASN I 236  ASN I 239 -1  O  ASN I 236   N  THR I 218           
SHEET    1  AD 6 VAL J 176  PHE J 179  0                                        
SHEET    2  AD 6 ILE J 107  VAL J 110  1  N  ILE J 109   O  PHE J 179           
SHEET    3  AD 6 ILE J  82  VAL J  85  1  N  ILE J  82   O  THR J 108           
SHEET    4  AD 6 VAL J 242  SER J 245  1  O  ILE J 244   N  VAL J  83           
SHEET    5  AD 6 LEU J 296  VAL J 298  1  O  ILE J 297   N  SER J 245           
SHEET    6  AD 6 ARG J 290  VAL J 293 -1  N  VAL J 293   O  LEU J 296           
SHEET    1  AE 3 MET J 130  ARG J 133  0                                        
SHEET    2  AE 3 TYR J 153  VAL J 156 -1  O  VAL J 156   N  MET J 130           
SHEET    3  AE 3 GLU J 148  ASP J 149 -1  N  GLU J 148   O  VAL J 155           
SHEET    1  AF 3 THR J 182  ARG J 190  0                                        
SHEET    2  AF 3 ARG J 212  TRP J 220 -1  O  ASN J 219   N  THR J 183           
SHEET    3  AF 3 ASN J 236  ASN J 239 -1  O  ASN J 236   N  THR J 218           
SHEET    1  AG 2 ARG J 274  LEU J 276  0                                        
SHEET    2  AG 2 ASN J 310  ARG J 311  1  O  ARG J 311   N  GLY J 275           
SHEET    1  AH 6 VAL K 176  ASN K 180  0                                        
SHEET    2  AH 6 ILE K 107  GLU K 111  1  N  ILE K 109   O  PHE K 179           
SHEET    3  AH 6 ILE K  82  VAL K  85  1  N  ILE K  84   O  THR K 108           
SHEET    4  AH 6 VAL K 242  SER K 245  1  O  ILE K 244   N  VAL K  83           
SHEET    5  AH 6 LEU K 296  VAL K 298  1  O  ILE K 297   N  SER K 245           
SHEET    6  AH 6 ARG K 290  VAL K 293 -1  N  VAL K 293   O  LEU K 296           
SHEET    1  AI 3 MET K 130  ARG K 133  0                                        
SHEET    2  AI 3 TYR K 153  VAL K 156 -1  O  VAL K 154   N  MET K 132           
SHEET    3  AI 3 GLU K 148  ASP K 149 -1  N  GLU K 148   O  VAL K 155           
SHEET    1  AJ 3 THR K 182  ARG K 190  0                                        
SHEET    2  AJ 3 ARG K 212  TRP K 220 -1  O  ASN K 219   N  THR K 183           
SHEET    3  AJ 3 ASN K 236  ASN K 239 -1  O  ASN K 236   N  THR K 218           
SHEET    1  AK 6 VAL L 176  PHE L 179  0                                        
SHEET    2  AK 6 ILE L 107  VAL L 110  1  N  ILE L 109   O  LYS L 177           
SHEET    3  AK 6 ILE L  82  VAL L  85  1  N  ILE L  82   O  THR L 108           
SHEET    4  AK 6 VAL L 242  SER L 245  1  O  ILE L 244   N  VAL L  85           
SHEET    5  AK 6 LEU L 296  VAL L 298  1  O  ILE L 297   N  SER L 245           
SHEET    6  AK 6 ARG L 290  VAL L 293 -1  N  VAL L 293   O  LEU L 296           
SHEET    1  AL 3 MET L 130  ARG L 133  0                                        
SHEET    2  AL 3 TYR L 153  VAL L 156 -1  O  VAL L 154   N  MET L 132           
SHEET    3  AL 3 GLU L 148  ASP L 149 -1  N  GLU L 148   O  VAL L 155           
SHEET    1  AM 3 THR L 182  ARG L 190  0                                        
SHEET    2  AM 3 ARG L 212  TRP L 220 -1  O  ALA L 214   N  ILE L 188           
SHEET    3  AM 3 ASN L 236  ASN L 239 -1  O  ASN L 236   N  THR L 218           
SHEET    1  AN 6 VAL M 176  ASN M 180  0                                        
SHEET    2  AN 6 ILE M 107  GLU M 111  1  N  ILE M 109   O  PHE M 179           
SHEET    3  AN 6 ILE M  82  VAL M  85  1  N  ILE M  82   O  THR M 108           
SHEET    4  AN 6 VAL M 242  SER M 245  1  O  ILE M 244   N  VAL M  83           
SHEET    5  AN 6 LEU M 296  VAL M 298  1  O  ILE M 297   N  ILE M 243           
SHEET    6  AN 6 ARG M 290  VAL M 293 -1  N  VAL M 293   O  LEU M 296           
SHEET    1  AO 3 MET M 130  ARG M 133  0                                        
SHEET    2  AO 3 TYR M 153  VAL M 156 -1  O  VAL M 154   N  MET M 132           
SHEET    3  AO 3 GLU M 148  ASP M 149 -1  N  GLU M 148   O  VAL M 155           
SHEET    1  AP 3 THR M 182  ARG M 190  0                                        
SHEET    2  AP 3 ARG M 212  TRP M 220 -1  O  ALA M 214   N  ILE M 188           
SHEET    3  AP 3 ASN M 236  ASN M 239 -1  O  ASN M 236   N  THR M 218           
SHEET    1  AQ 6 VAL N 176  ASN N 180  0                                        
SHEET    2  AQ 6 ILE N 107  GLU N 111  1  N  ILE N 109   O  PHE N 179           
SHEET    3  AQ 6 ILE N  82  VAL N  85  1  N  ILE N  82   O  THR N 108           
SHEET    4  AQ 6 VAL N 242  SER N 245  1  O  ILE N 244   N  VAL N  83           
SHEET    5  AQ 6 LEU N 296  VAL N 298  1  O  ILE N 297   N  SER N 245           
SHEET    6  AQ 6 ARG N 290  VAL N 293 -1  N  VAL N 293   O  LEU N 296           
SHEET    1  AR 3 MET N 130  ARG N 133  0                                        
SHEET    2  AR 3 TYR N 153  VAL N 156 -1  O  VAL N 154   N  MET N 132           
SHEET    3  AR 3 GLU N 148  ASP N 149 -1  N  GLU N 148   O  VAL N 155           
SHEET    1  AS 3 THR N 182  LYS N 191  0                                        
SHEET    2  AS 3 VAL N 211  TRP N 220 -1  O  ASN N 219   N  THR N 183           
SHEET    3  AS 3 ASN N 236  ASN N 239 -1  O  ASN N 236   N  THR N 218           
SHEET    1  AT 6 VAL O 176  ASN O 180  0                                        
SHEET    2  AT 6 ILE O 107  GLU O 111  1  N  ILE O 109   O  LYS O 177           
SHEET    3  AT 6 ILE O  82  VAL O  85  1  N  ILE O  84   O  THR O 108           
SHEET    4  AT 6 VAL O 242  SER O 245  1  O  ILE O 244   N  VAL O  83           
SHEET    5  AT 6 LEU O 296  VAL O 298  1  O  ILE O 297   N  SER O 245           
SHEET    6  AT 6 ARG O 290  VAL O 293 -1  N  VAL O 293   O  LEU O 296           
SHEET    1  AU 3 MET O 130  ARG O 133  0                                        
SHEET    2  AU 3 TYR O 153  VAL O 156 -1  O  VAL O 154   N  MET O 132           
SHEET    3  AU 3 GLU O 148  ASP O 149 -1  N  GLU O 148   O  VAL O 155           
SHEET    1  AV 3 THR O 182  LYS O 191  0                                        
SHEET    2  AV 3 VAL O 211  TRP O 220 -1  O  ALA O 214   N  ILE O 188           
SHEET    3  AV 3 ASN O 236  ASN O 239 -1  O  ASN O 236   N  THR O 218           
SHEET    1  AW 6 VAL P 176  ASN P 180  0                                        
SHEET    2  AW 6 ILE P 107  GLU P 111  1  N  ILE P 109   O  PHE P 179           
SHEET    3  AW 6 ILE P  82  VAL P  85  1  N  ILE P  82   O  THR P 108           
SHEET    4  AW 6 VAL P 242  SER P 245  1  O  ILE P 244   N  VAL P  83           
SHEET    5  AW 6 LEU P 296  VAL P 298  1  O  ILE P 297   N  SER P 245           
SHEET    6  AW 6 ARG P 290  VAL P 293 -1  N  VAL P 293   O  LEU P 296           
SHEET    1  AX 3 MET P 130  ARG P 133  0                                        
SHEET    2  AX 3 TYR P 153  VAL P 156 -1  O  VAL P 154   N  MET P 132           
SHEET    3  AX 3 GLU P 148  ASP P 149 -1  N  GLU P 148   O  VAL P 155           
SHEET    1  AY 3 THR P 182  ARG P 190  0                                        
SHEET    2  AY 3 ARG P 212  TRP P 220 -1  O  GLY P 215   N  ILE P 188           
SHEET    3  AY 3 ASN P 236  ASN P 239 -1  O  ASN P 236   N  THR P 218           
LINK         C   SER A 231                 N   DHA A 232     1555   1555  1.33  
LINK         C   DHA A 232                 N   MET A 233     1555   1555  1.33  
LINK         C   SER B 231                 N   DHA B 232     1555   1555  1.33  
LINK         C   DHA B 232                 N   MET B 233     1555   1555  1.33  
LINK         C   SER C 231                 N   DHA C 232     1555   1555  1.33  
LINK         C   DHA C 232                 N   MET C 233     1555   1555  1.33  
LINK         C   SER D 231                 N   DHA D 232     1555   1555  1.33  
LINK         C   DHA D 232                 N   MET D 233     1555   1555  1.33  
LINK         C   SER E 231                 N   DHA E 232     1555   1555  1.33  
LINK         C   DHA E 232                 N   MET E 233     1555   1555  1.33  
LINK         C   SER F 231                 N   DHA F 232     1555   1555  1.33  
LINK         C   DHA F 232                 N   MET F 233     1555   1555  1.33  
LINK         C   SER G 231                 N   DHA G 232     1555   1555  1.33  
LINK         C   DHA G 232                 N   MET G 233     1555   1555  1.33  
LINK         C   SER H 231                 N   DHA H 232     1555   1555  1.33  
LINK         C   DHA H 232                 N   MET H 233     1555   1555  1.33  
LINK         C   SER I 231                 N   DHA I 232     1555   1555  1.33  
LINK         C   DHA I 232                 N   MET I 233     1555   1555  1.33  
LINK         C   SER J 231                 N   DHA J 232     1555   1555  1.33  
LINK         C   DHA J 232                 N   MET J 233     1555   1555  1.33  
LINK         C   SER K 231                 N   DHA K 232     1555   1555  1.33  
LINK         C   DHA K 232                 N   MET K 233     1555   1555  1.33  
LINK         C   SER L 231                 N   DHA L 232     1555   1555  1.33  
LINK         C   DHA L 232                 N   MET L 233     1555   1555  1.33  
LINK         C   SER M 231                 N   DHA M 232     1555   1555  1.33  
LINK         C   DHA M 232                 N   MET M 233     1555   1555  1.33  
LINK         C   SER N 231                 N   DHA N 232     1555   1555  1.33  
LINK         C   DHA N 232                 N   MET N 233     1555   1555  1.33  
LINK         C   SER O 231                 N   DHA O 232     1555   1555  1.33  
LINK         C   DHA O 232                 N   MET O 233     1555   1555  1.33  
LINK         C   SER P 231                 N   DHA P 232     1555   1555  1.33  
LINK         C   DHA P 232                 N   MET P 233     1555   1555  1.33  
LINK         NE2 HIS C 249                FE   FE2 C 345     1555   1555  2.47  
LINK         NE2 HIS G 249                FE   FE2 G 345     1555   1555  2.30  
LINK         NE2 HIS H 249                FE   FE2 H 345     1555   1555  2.29  
LINK         NE2 HIS I 249                FE   FE2 I 345     1555   1555  2.31  
LINK         NE2 HIS K 249                FE   FE2 K 345     1555   1555  2.48  
LINK         NE2 HIS N 249                FE   FE2 N 345     1555   1555  2.43  
LINK         N3T AHZ A 500                FE   FE2 A 345     1555   1555  2.43  
LINK         N3T AHZ B 500                FE   FE2 B 345     1555   1555  2.24  
LINK         N3T AHZ D 500                FE   FE2 D 345     1555   1555  2.41  
LINK         N3T AHZ E 500                FE   FE2 E 345     1555   1555  2.51  
LINK         N3T AHZ G 500                FE   FE2 G 345     1555   1555  2.44  
LINK         N3T AHZ I 500                FE   FE2 I 345     1555   1555  2.45  
LINK         N3T AHZ J 500                FE   FE2 J 345     1555   1555  2.35  
LINK         N3T AHZ L 500                FE   FE2 L 345     1555   1555  2.42  
LINK         N3T AHZ M 500                FE   FE2 M 345     1555   1555  2.24  
LINK         N3T AHZ N 500                FE   FE2 N 345     1555   1555  2.28  
LINK         N3T AHZ O 500                FE   FE2 K 346     1555   1555  2.25  
LINK         N3T AHZ P 500                FE   FE2 M 346     1555   1555  2.25  
LINK         N3T AHZ H 500                FE   FE2 H 345     1555   1555  2.60  
LINK         NE2 HIS E 249                FE   FE2 E 345     1555   1555  2.61  
LINK         NE2 HIS A 249                FE   FE2 A 345     1555   1555  2.63  
LINK         N3T AHZ K 500                FE   FE2 K 345     1555   1555  2.64  
LINK         N3T AHZ F 500                FE   FE2 F 345     1555   1555  2.66  
LINK         NE2 HIS F 249                FE   FE2 F 345     1555   1555  2.68  
LINK         NE2 HIS J 249                FE   FE2 J 345     1555   1555  2.70  
LINK         N3T AHZ C 500                FE   FE2 C 345     1555   1555  2.71  
LINK         NE2 HIS B 249                FE   FE2 B 345     1555   1555  2.72  
LINK         NE2 HIS D 249                FE   FE2 D 345     1555   1555  2.73  
LINK         NE2 HIS L 249                FE   FE2 L 345     1555   1555  2.74  
LINK         NE2 HIS M 249                FE   FE2 M 345     1555   1555  2.78  
CISPEP   1 LYS A  134    PRO A  135          0         2.35                     
CISPEP   2 LYS B  134    PRO B  135          0         2.06                     
CISPEP   3 LYS C  134    PRO C  135          0         2.14                     
CISPEP   4 LYS D  134    PRO D  135          0         0.68                     
CISPEP   5 LYS E  134    PRO E  135          0         2.22                     
CISPEP   6 LYS F  134    PRO F  135          0         1.40                     
CISPEP   7 LYS G  134    PRO G  135          0         1.48                     
CISPEP   8 LYS H  134    PRO H  135          0         1.34                     
CISPEP   9 LYS I  134    PRO I  135          0         1.20                     
CISPEP  10 LYS J  134    PRO J  135          0         1.55                     
CISPEP  11 LYS K  134    PRO K  135          0         1.91                     
CISPEP  12 LYS L  134    PRO L  135          0         1.99                     
CISPEP  13 LYS M  134    PRO M  135          0         1.77                     
CISPEP  14 LYS N  134    PRO N  135          0         1.30                     
CISPEP  15 LYS O  134    PRO O  135          0         2.02                     
CISPEP  16 LYS P  134    PRO P  135          0         0.26                     
SITE     1 AC1 27 VAL A  85  GLY A  86  GLY A  88  SER A  89                    
SITE     2 AC1 27 CYS A  90  GLU A 111  ALA A 112  GLY A 118                    
SITE     3 AC1 27 GLY A 119  VAL A 184  THR A 246  THR A 247                    
SITE     4 AC1 27 GLY A 248  HIS A 249  PHE A 253  GLY A 300                    
SITE     5 AC1 27 MET A 301  ARG A 311  MET A 312  GLY A 313                    
SITE     6 AC1 27 MET A 319  FE2 A 345  HOH A 350  HOH A 364                    
SITE     7 AC1 27 HOH A 366  HOH A 385  ASP F 234                               
SITE     1 AC2  3 HIS A 249  AHZ A 500  ASP F 234                               
SITE     1 AC3 26 GLY B  86  SER B  89  CYS B  90  VAL B 110                    
SITE     2 AC3 26 GLU B 111  ALA B 112  GLY B 118  GLY B 119                    
SITE     3 AC3 26 THR B 182  THR B 183  VAL B 184  THR B 246                    
SITE     4 AC3 26 THR B 247  GLY B 248  HIS B 249  PHE B 253                    
SITE     5 AC3 26 GLY B 300  MET B 301  ARG B 311  MET B 312                    
SITE     6 AC3 26 GLY B 313  MET B 319  FE2 B 345  HOH B 355                    
SITE     7 AC3 26 ASP H 234  PRO H 235                                          
SITE     1 AC4  4 HIS B 249  ARG B 311  AHZ B 500  ASP H 234                    
SITE     1 AC5 27 ASP A 234  GLY C  86  GLY C  88  SER C  89                    
SITE     2 AC5 27 CYS C  90  VAL C 110  GLU C 111  ALA C 112                    
SITE     3 AC5 27 GLY C 118  GLY C 119  THR C 183  VAL C 184                    
SITE     4 AC5 27 THR C 246  THR C 247  GLY C 248  HIS C 249                    
SITE     5 AC5 27 PHE C 253  GLY C 300  MET C 301  ARG C 311                    
SITE     6 AC5 27 MET C 312  GLY C 313  MET C 319  FE2 C 345                    
SITE     7 AC5 27 HOH C 347  HOH C 368  HOH C 374                               
SITE     1 AC6  3 HIS C 249  ARG C 311  AHZ C 500                               
SITE     1 AC7 27 ASP B 234  VAL D  85  GLY D  86  GLY D  88                    
SITE     2 AC7 27 SER D  89  CYS D  90  GLU D 111  ALA D 112                    
SITE     3 AC7 27 GLY D 118  GLY D 119  THR D 183  VAL D 184                    
SITE     4 AC7 27 THR D 246  THR D 247  GLY D 248  HIS D 249                    
SITE     5 AC7 27 PHE D 253  GLY D 300  MET D 301  ARG D 311                    
SITE     6 AC7 27 MET D 312  GLY D 313  MET D 319  FE2 D 345                    
SITE     7 AC7 27 HOH D 347  HOH D 354  HOH D 357                               
SITE     1 AC8  4 ASP B 234  HIS D 249  ARG D 311  AHZ D 500                    
SITE     1 AC9 25 ASP D 234  VAL E  85  GLY E  86  SER E  89                    
SITE     2 AC9 25 CYS E  90  GLU E 111  ALA E 112  GLY E 118                    
SITE     3 AC9 25 GLY E 119  THR E 183  VAL E 184  THR E 246                    
SITE     4 AC9 25 THR E 247  GLY E 248  HIS E 249  PHE E 253                    
SITE     5 AC9 25 GLY E 300  MET E 301  ARG E 311  MET E 312                    
SITE     6 AC9 25 GLY E 313  MET E 319  FE2 E 345  HOH E 350                    
SITE     7 AC9 25 HOH E 369                                                     
SITE     1 BC1  2 HIS E 249  AHZ E 500                                          
SITE     1 BC2 27 VAL F  85  GLY F  86  SER F  89  CYS F  90                    
SITE     2 BC2 27 VAL F 110  GLU F 111  ALA F 112  GLY F 118                    
SITE     3 BC2 27 GLY F 119  THR F 183  VAL F 184  THR F 246                    
SITE     4 BC2 27 THR F 247  GLY F 248  PHE F 253  GLY F 300                    
SITE     5 BC2 27 MET F 301  ARG F 311  MET F 312  GLY F 313                    
SITE     6 BC2 27 MET F 319  FE2 F 345  HOH F 347  HOH F 359                    
SITE     7 BC2 27 HOH F 360  HOH F 361  ASP G 234                               
SITE     1 BC3  2 HIS F 249  AHZ F 500                                          
SITE     1 BC4 27 ASP C 234  VAL G  85  GLY G  86  GLY G  88                    
SITE     2 BC4 27 SER G  89  CYS G  90  VAL G 110  GLU G 111                    
SITE     3 BC4 27 ALA G 112  GLY G 118  GLY G 119  VAL G 184                    
SITE     4 BC4 27 THR G 246  THR G 247  GLY G 248  HIS G 249                    
SITE     5 BC4 27 PHE G 253  GLY G 300  MET G 301  ARG G 311                    
SITE     6 BC4 27 MET G 312  GLY G 313  MET G 319  FE2 G 345                    
SITE     7 BC4 27 HOH G 348  HOH G 361  HOH G 362                               
SITE     1 BC5  3 ASP C 234  HIS G 249  AHZ G 500                               
SITE     1 BC6 23 ASP E 234  GLY H  86  SER H  89  CYS H  90                    
SITE     2 BC6 23 VAL H 110  GLU H 111  ALA H 112  GLY H 118                    
SITE     3 BC6 23 GLY H 119  THR H 183  VAL H 184  THR H 246                    
SITE     4 BC6 23 THR H 247  GLY H 248  PHE H 253  GLY H 300                    
SITE     5 BC6 23 MET H 301  ARG H 311  MET H 312  GLY H 313                    
SITE     6 BC6 23 MET H 319  FE2 H 345  HOH H 347                               
SITE     1 BC7  3 HIS H 249  ARG H 311  AHZ H 500                               
SITE     1 BC8 27 VAL I  85  GLY I  86  SER I  89  CYS I  90                    
SITE     2 BC8 27 VAL I 110  GLU I 111  ALA I 112  GLY I 118                    
SITE     3 BC8 27 GLY I 119  THR I 183  VAL I 184  THR I 246                    
SITE     4 BC8 27 THR I 247  GLY I 248  HIS I 249  PHE I 253                    
SITE     5 BC8 27 GLY I 300  MET I 301  ARG I 311  MET I 312                    
SITE     6 BC8 27 GLY I 313  MET I 319  FE2 I 345  HOH I 355                    
SITE     7 BC8 27 HOH I 366  HOH I 367  ASP N 234                               
SITE     1 BC9  3 HIS I 249  AHZ I 500  ASP N 234                               
SITE     1 CC1 26 VAL J  85  GLY J  86  SER J  89  CYS J  90                    
SITE     2 CC1 26 VAL J 110  GLU J 111  ALA J 112  GLY J 118                    
SITE     3 CC1 26 GLY J 119  THR J 183  VAL J 184  THR J 246                    
SITE     4 CC1 26 THR J 247  GLY J 248  HIS J 249  PHE J 253                    
SITE     5 CC1 26 GLY J 300  MET J 301  ARG J 311  MET J 312                    
SITE     6 CC1 26 GLY J 313  MET J 319  FE2 J 345  HOH J 358                    
SITE     7 CC1 26 HOH J 359  ASP P 234                                          
SITE     1 CC2  4 HIS J 249  ARG J 311  AHZ J 500  ASP P 234                    
SITE     1 CC3 27 ASP I 234  VAL K  85  GLY K  86  SER K  89                    
SITE     2 CC3 27 CYS K  90  VAL K 110  GLU K 111  ALA K 112                    
SITE     3 CC3 27 GLY K 118  GLY K 119  THR K 183  VAL K 184                    
SITE     4 CC3 27 THR K 246  THR K 247  GLY K 248  HIS K 249                    
SITE     5 CC3 27 PHE K 253  GLY K 300  MET K 301  ARG K 311                    
SITE     6 CC3 27 MET K 312  GLY K 313  MET K 319  FE2 K 345                    
SITE     7 CC3 27 HOH K 348  HOH K 352  HOH K 362                               
SITE     1 CC4  2 HIS K 249  AHZ K 500                                          
SITE     1 CC5  3 ASP K 234  HIS O 249  AHZ O 500                               
SITE     1 CC6 24 ASP J 234  GLY L  86  SER L  89  CYS L  90                    
SITE     2 CC6 24 VAL L 110  GLU L 111  ALA L 112  GLY L 118                    
SITE     3 CC6 24 GLY L 119  THR L 183  VAL L 184  THR L 246                    
SITE     4 CC6 24 THR L 247  GLY L 248  HIS L 249  PHE L 253                    
SITE     5 CC6 24 GLY L 300  MET L 301  ARG L 311  MET L 312                    
SITE     6 CC6 24 GLY L 313  MET L 319  FE2 L 345  HOH L 384                    
SITE     1 CC7  4 ASP J 234  HIS L 249  ARG L 311  AHZ L 500                    
SITE     1 CC8 24 ASP L 234  GLY M  86  SER M  89  CYS M  90                    
SITE     2 CC8 24 VAL M 110  GLU M 111  ALA M 112  GLY M 118                    
SITE     3 CC8 24 GLY M 119  THR M 183  VAL M 184  THR M 246                    
SITE     4 CC8 24 THR M 247  GLY M 248  HIS M 249  PHE M 253                    
SITE     5 CC8 24 GLY M 300  MET M 301  ARG M 311  MET M 312                    
SITE     6 CC8 24 GLY M 313  MET M 319  FE2 M 345  HOH M 362                    
SITE     1 CC9  4 ASP L 234  HIS M 249  ARG M 311  AHZ M 500                    
SITE     1 DC1  4 ASP M 234  HIS P 249  ARG P 311  AHZ P 500                    
SITE     1 DC2 27 VAL N  85  GLY N  86  GLY N  88  SER N  89                    
SITE     2 DC2 27 CYS N  90  VAL N 110  GLU N 111  ALA N 112                    
SITE     3 DC2 27 GLY N 118  GLY N 119  THR N 183  VAL N 184                    
SITE     4 DC2 27 THR N 246  THR N 247  GLY N 248  HIS N 249                    
SITE     5 DC2 27 PHE N 253  GLY N 300  MET N 301  ARG N 311                    
SITE     6 DC2 27 MET N 312  GLY N 313  MET N 319  FE2 N 345                    
SITE     7 DC2 27 HOH N 348  HOH N 360  ASP O 234                               
SITE     1 DC3  3 HIS N 249  AHZ N 500  ASP O 234                               
SITE     1 DC4 26 ASP K 234  FE2 K 346  VAL O  85  GLY O  86                    
SITE     2 DC4 26 SER O  89  CYS O  90  VAL O 110  GLU O 111                    
SITE     3 DC4 26 ALA O 112  GLY O 118  GLY O 119  THR O 183                    
SITE     4 DC4 26 VAL O 184  THR O 246  THR O 247  GLY O 248                    
SITE     5 DC4 26 HIS O 249  PHE O 253  GLY O 300  MET O 301                    
SITE     6 DC4 26 ARG O 311  MET O 312  GLY O 313  MET O 319                    
SITE     7 DC4 26 HOH O 349  HOH O 350                                          
SITE     1 DC5 27 ASP M 234  FE2 M 346  VAL P  85  GLY P  86                    
SITE     2 DC5 27 GLY P  88  SER P  89  CYS P  90  VAL P 110                    
SITE     3 DC5 27 GLU P 111  ALA P 112  GLY P 118  GLY P 119                    
SITE     4 DC5 27 THR P 183  VAL P 184  THR P 246  THR P 247                    
SITE     5 DC5 27 GLY P 248  HIS P 249  PHE P 253  GLY P 300                    
SITE     6 DC5 27 MET P 301  ARG P 311  MET P 312  GLY P 313                    
SITE     7 DC5 27 MET P 319  HOH P 348  HOH P 365                               
CRYST1  158.237  125.914  158.208  90.00  90.22  90.00 P 1 2 1      32          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.006320  0.000000  0.000024        0.00000                         
SCALE2      0.000000  0.007942  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.006321        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system