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Database: PDB
Entry: 3PG9
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Original site: 3PG9 
HEADER    TRANSFERASE/TRANSFERASE INHIBITOR       31-OCT-10   3PG9              
TITLE     THERMOTOGA MARITIMA DAH7P SYNTHASE IN COMPLEX WITH INHIBITOR          
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE;               
COMPND   3 CHAIN: A, B, C, D, E, F, G, H;                                       
COMPND   4 SYNONYM: 3-DEOXY-D-ARABINO-HEPTULOSONATE 7-PHOSPHATE SYNTHASE, DAHP  
COMPND   5 SYNTHASE, PHOSPHO-2-KETO-3-DEOXYHEPTONATE ALDOLASE;                  
COMPND   6 EC: 2.5.1.54;                                                        
COMPND   7 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: THERMOTOGA MARITIMA;                            
SOURCE   3 ORGANISM_TAXID: 2336;                                                
SOURCE   4 STRAIN: MSB8 (DSM3109);                                              
SOURCE   5 GENE: AROF;                                                          
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);                                 
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PT7-7                                     
KEYWDS    THERMOTOGA MARITIMA, DAH7PS, SHIKIMATE PATHWAY, AROMATIC              
KEYWDS   2 BIOSYNTHESIS, TYR-BOUND, TIM BARREL, ACT DOMAIN, FERREDOXIN-LIKE     
KEYWDS   3 DOMAIN, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX,      
KEYWDS   4 ALLOSTERIC REGULATION                                                
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    P.J.CROSS,R.C.J.DOBSON,M.L.PATCHETT,E.J.PARKER                        
REVDAT   2   22-AUG-12 3PG9    1       JRNL   VERSN                             
REVDAT   1   26-JAN-11 3PG9    0                                                
JRNL        AUTH   P.J.CROSS,R.C.J.DOBSON,M.L.PATCHETT,E.J.PARKER               
JRNL        TITL   TYROSINE LATCHING OF A REGULATORY GATE AFFORDS ALLOSTERIC    
JRNL        TITL 2 CONTROL OF AROMATIC AMINO ACID BIOSYNTHESIS                  
JRNL        REF    J.BIOL.CHEM.                  V. 286 10216 2011              
JRNL        REFN                   ISSN 0021-9258                               
JRNL        PMID   21282100                                                     
JRNL        DOI    10.1074/JBC.M110.209924                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.35 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.6.1_357)                    
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN             
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-                     
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,              
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL            
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE                  
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM             
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,             
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER                
REMARK   3               : ZWART                                                
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.35                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 52.57                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 0.000                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 97.2                           
REMARK   3   NUMBER OF REFLECTIONS             : 104678                         
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.172                           
REMARK   3   R VALUE            (WORKING SET) : 0.171                           
REMARK   3   FREE R VALUE                     : 0.222                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 2.010                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 2100                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 52.5797 -  5.0615    0.94    10039   210  0.1495 0.1772        
REMARK   3     2  5.0615 -  4.0179    0.96    10163   210  0.1385 0.1860        
REMARK   3     3  4.0179 -  3.5101    0.97    10210   210  0.1577 0.2323        
REMARK   3     4  3.5101 -  3.1893    0.97    10265   210  0.1748 0.2147        
REMARK   3     5  3.1893 -  2.9607    0.97    10254   210  0.1842 0.2484        
REMARK   3     6  2.9607 -  2.7861    0.98    10297   210  0.1872 0.2486        
REMARK   3     7  2.7861 -  2.6466    0.98    10319   210  0.1862 0.2397        
REMARK   3     8  2.6466 -  2.5314    0.98    10339   210  0.1843 0.2573        
REMARK   3     9  2.5314 -  2.4340    0.98    10315   210  0.1861 0.2617        
REMARK   3    10  2.4340 -  2.3500    0.99    10377   210  0.2016 0.2545        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : 0.33                                          
REMARK   3   B_SOL              : 38.46                                         
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.360            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 20.510           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 36.09                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 36.10                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : -0.08750                                             
REMARK   3    B22 (A**2) : 0.30730                                              
REMARK   3    B33 (A**2) : -0.21980                                             
REMARK   3    B12 (A**2) : 0.00000                                              
REMARK   3    B13 (A**2) : 0.23920                                              
REMARK   3    B23 (A**2) : 0.00000                                              
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.003          20915                                  
REMARK   3   ANGLE     :  0.654          28307                                  
REMARK   3   CHIRALITY :  0.044           3299                                  
REMARK   3   PLANARITY :  0.002           3663                                  
REMARK   3   DIHEDRAL  : 12.219           7722                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 56                                         
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: (chain A and resid 1:34)                               
REMARK   3    ORIGIN FOR THE GROUP (A): -13.9390  47.9413  29.7771              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2968 T22:   0.1004                                     
REMARK   3      T33:   0.1946 T12:   0.0114                                     
REMARK   3      T13:   0.0075 T23:   0.0383                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.2094 L22:   0.1207                                     
REMARK   3      L33:   3.8644 L12:  -0.4329                                     
REMARK   3      L13:   0.3283 L23:   0.0979                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0394 S12:   0.1624 S13:   0.5215                       
REMARK   3      S21:  -0.3795 S22:   0.0268 S23:   0.1510                       
REMARK   3      S31:  -0.9018 S32:  -0.2958 S33:   0.0056                       
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: (chain A and resid 35:67)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -10.7325  42.8752  36.1542              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3191 T22:   0.3108                                     
REMARK   3      T33:   0.2195 T12:  -0.0198                                     
REMARK   3      T13:  -0.0155 T23:   0.0006                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.1086 L22:   1.2049                                     
REMARK   3      L33:   0.1073 L12:  -0.1206                                     
REMARK   3      L13:   0.3224 L23:   0.0632                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0143 S12:  -0.4316 S13:  -0.0599                       
REMARK   3      S21:   0.2850 S22:   0.0273 S23:  -0.1407                       
REMARK   3      S31:   0.0606 S32:  -0.0572 S33:  -0.0131                       
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: (chain A and resid 68:130)                             
REMARK   3    ORIGIN FOR THE GROUP (A):  14.1081  26.3676  62.6002              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0261 T22:   0.0849                                     
REMARK   3      T33:   0.1519 T12:  -0.0077                                     
REMARK   3      T13:  -0.0819 T23:   0.0080                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.2183 L22:   1.4584                                     
REMARK   3      L33:   1.3547 L12:   0.2508                                     
REMARK   3      L13:   0.1362 L23:   0.4063                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0875 S12:  -0.0849 S13:  -0.0741                       
REMARK   3      S21:   0.2512 S22:   0.0434 S23:  -0.2650                       
REMARK   3      S31:  -0.1412 S32:   0.1003 S33:   0.0514                       
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: (chain A and resid 131:141)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -6.5492  23.9772  76.6342              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7314 T22:   0.7348                                     
REMARK   3      T33:   1.1551 T12:  -0.1258                                     
REMARK   3      T13:  -0.3209 T23:   0.0949                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.4900 L22:   4.2122                                     
REMARK   3      L33:   8.0032 L12:  -1.7250                                     
REMARK   3      L13:  -3.1624 L23:   1.9845                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -1.0482 S12:   0.5019 S13:   1.0485                       
REMARK   3      S21:   0.3642 S22:  -0.3492 S23:   0.7543                       
REMARK   3      S31:  -0.7575 S32:  -0.6259 S33:   1.2870                       
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: (chain A and resid 142:205)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   7.9109  33.7038  69.9063              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2264 T22:   0.1754                                     
REMARK   3      T33:   0.1950 T12:   0.0050                                     
REMARK   3      T13:  -0.0961 T23:  -0.0715                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.8021 L22:   2.4650                                     
REMARK   3      L33:   3.1809 L12:  -0.6456                                     
REMARK   3      L13:   1.1580 L23:  -0.1135                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1690 S12:  -0.1755 S13:   0.4063                       
REMARK   3      S21:   0.4718 S22:  -0.2452 S23:  -0.0033                       
REMARK   3      S31:  -0.7498 S32:  -0.0739 S33:   0.4067                       
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: (chain A and resid 206:267)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   1.9021  27.3871  52.6944              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1638 T22:   0.1079                                     
REMARK   3      T33:   0.1211 T12:  -0.0117                                     
REMARK   3      T13:  -0.0368 T23:   0.0026                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.3426 L22:   0.4079                                     
REMARK   3      L33:   0.8992 L12:   0.3493                                     
REMARK   3      L13:  -0.4148 L23:   0.2156                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1210 S12:   0.0201 S13:   0.0327                       
REMARK   3      S21:   0.1053 S22:   0.0363 S23:  -0.0208                       
REMARK   3      S31:  -0.1336 S32:  -0.0209 S33:   0.1096                       
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: (chain A and resid 268:338)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  10.6007  13.1089  61.9885              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1441 T22:   0.0768                                     
REMARK   3      T33:   0.2012 T12:   0.0199                                     
REMARK   3      T13:  -0.0538 T23:   0.0235                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.7560 L22:   0.6826                                     
REMARK   3      L33:   2.8513 L12:   1.1723                                     
REMARK   3      L13:  -0.1447 L23:  -0.5544                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0408 S12:   0.0670 S13:  -0.2276                       
REMARK   3      S21:   0.1286 S22:  -0.1090 S23:  -0.3645                       
REMARK   3      S31:   0.3652 S32:  -0.1345 S33:   0.0246                       
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    SELECTION: (chain B and resid 1:51)                               
REMARK   3    ORIGIN FOR THE GROUP (A): -26.2202  -3.6034  68.7566              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2949 T22:   0.2943                                     
REMARK   3      T33:   0.4176 T12:   0.0140                                     
REMARK   3      T13:   0.0065 T23:   0.1070                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.6333 L22:   3.6351                                     
REMARK   3      L33:   1.2619 L12:  -0.7939                                     
REMARK   3      L13:   0.2393 L23:  -1.0144                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1588 S12:  -0.1783 S13:  -0.3806                       
REMARK   3      S21:  -0.0883 S22:  -0.0392 S23:   0.7488                       
REMARK   3      S31:   0.1446 S32:  -0.1901 S33:  -0.1563                       
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    SELECTION: (chain B and resid 52:78)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -16.8049  -2.8566  59.4517              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2130 T22:   0.1008                                     
REMARK   3      T33:   0.2309 T12:   0.0108                                     
REMARK   3      T13:   0.0005 T23:   0.0700                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.7870 L22:   0.8701                                     
REMARK   3      L33:   1.0337 L12:   0.0205                                     
REMARK   3      L13:   0.2092 L23:  -0.8006                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0665 S12:  -0.1063 S13:  -0.2587                       
REMARK   3      S21:  -0.2029 S22:   0.2154 S23:   0.1466                       
REMARK   3      S31:   0.0978 S32:  -0.0474 S33:  -0.0621                       
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    SELECTION: (chain B and resid 79:125)                             
REMARK   3    ORIGIN FOR THE GROUP (A):   8.0571  -0.1761  30.7694              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1948 T22:   0.1360                                     
REMARK   3      T33:   0.1729 T12:   0.0825                                     
REMARK   3      T13:   0.0587 T23:  -0.0228                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.6793 L22:   0.8840                                     
REMARK   3      L33:   1.4959 L12:   0.7074                                     
REMARK   3      L13:  -0.9278 L23:   0.7702                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0515 S12:   0.1988 S13:  -0.1386                       
REMARK   3      S21:  -0.2030 S22:  -0.0879 S23:  -0.2708                       
REMARK   3      S31:   0.3197 S32:   0.3615 S33:   0.1600                       
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    SELECTION: (chain B and resid 126:143)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -9.0235   9.8143  22.1459              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5122 T22:   0.3324                                     
REMARK   3      T33:   0.2902 T12:   0.1675                                     
REMARK   3      T13:   0.0551 T23:   0.0086                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.0101 L22:   3.2769                                     
REMARK   3      L33:   2.1946 L12:  -2.4233                                     
REMARK   3      L13:   0.2566 L23:  -1.2108                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1934 S12:   0.4894 S13:   0.4162                       
REMARK   3      S21:   0.4795 S22:  -0.1738 S23:   0.2223                       
REMARK   3      S31:  -1.3140 S32:  -0.4763 S33:  -0.1518                       
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    SELECTION: (chain B and resid 144:205)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -5.8218  -3.7478  28.6783              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2882 T22:   0.1459                                     
REMARK   3      T33:   0.1882 T12:   0.0273                                     
REMARK   3      T13:  -0.0161 T23:  -0.0613                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.2846 L22:   1.8158                                     
REMARK   3      L33:   1.5616 L12:   1.3241                                     
REMARK   3      L13:   0.5374 L23:  -0.1426                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0522 S12:  -0.0063 S13:  -0.0341                       
REMARK   3      S21:  -0.3375 S22:  -0.0367 S23:   0.3362                       
REMARK   3      S31:   0.3521 S32:  -0.2108 S33:   0.0785                       
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    SELECTION: (chain B and resid 206:267)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -5.6871   4.3754  46.0572              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1769 T22:   0.0814                                     
REMARK   3      T33:   0.1766 T12:  -0.0065                                     
REMARK   3      T13:   0.0165 T23:   0.0025                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6530 L22:   1.5058                                     
REMARK   3      L33:   1.5604 L12:   0.3801                                     
REMARK   3      L13:   0.3907 L23:   0.9565                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0204 S12:  -0.1134 S13:  -0.0695                       
REMARK   3      S21:  -0.0591 S22:  -0.0026 S23:   0.1694                       
REMARK   3      S31:   0.0731 S32:  -0.0017 S33:  -0.0145                       
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    SELECTION: (chain B and resid 268:338)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   8.9680  11.3511  35.8750              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1490 T22:   0.1236                                     
REMARK   3      T33:   0.1596 T12:   0.0254                                     
REMARK   3      T13:   0.0531 T23:   0.0002                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.4817 L22:   0.2861                                     
REMARK   3      L33:   2.6026 L12:   0.2455                                     
REMARK   3      L13:  -0.6555 L23:   0.3317                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0796 S12:  -0.0949 S13:   0.0186                       
REMARK   3      S21:  -0.0098 S22:   0.0376 S23:  -0.1685                       
REMARK   3      S31:  -0.1603 S32:   0.0872 S33:  -0.1202                       
REMARK   3   TLS GROUP : 15                                                     
REMARK   3    SELECTION: (chain C and resid 1:62)                               
REMARK   3    ORIGIN FOR THE GROUP (A): -28.7270  38.6609   6.1590              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2061 T22:   0.1401                                     
REMARK   3      T33:   0.1677 T12:   0.0417                                     
REMARK   3      T13:  -0.0337 T23:  -0.0314                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.7559 L22:   1.3829                                     
REMARK   3      L33:   0.5132 L12:  -0.5587                                     
REMARK   3      L13:  -0.2209 L23:   0.5713                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1319 S12:  -0.0724 S13:   0.0284                       
REMARK   3      S21:   0.2765 S22:   0.0720 S23:   0.1022                       
REMARK   3      S31:   0.0577 S32:  -0.0520 S33:   0.0609                       
REMARK   3   TLS GROUP : 16                                                     
REMARK   3    SELECTION: (chain C and resid 63:76)                              
REMARK   3    ORIGIN FOR THE GROUP (A): -14.9781  23.3444   5.2666              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2128 T22:   0.1885                                     
REMARK   3      T33:   0.0675 T12:   0.1136                                     
REMARK   3      T13:  -0.0429 T23:  -0.0284                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.8794 L22:   4.3899                                     
REMARK   3      L33:   0.2230 L12:  -2.2313                                     
REMARK   3      L13:  -0.5525 L23:   0.6360                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3841 S12:  -0.3188 S13:   0.0906                       
REMARK   3      S21:   0.8651 S22:   0.2055 S23:  -0.1497                       
REMARK   3      S31:   0.0220 S32:   0.1984 S33:   0.1013                       
REMARK   3   TLS GROUP : 17                                                     
REMARK   3    SELECTION: (chain C and resid 77:129)                             
REMARK   3    ORIGIN FOR THE GROUP (A):  -7.9929  -5.9656  -1.8999              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3369 T22:   0.1987                                     
REMARK   3      T33:   0.2339 T12:   0.0852                                     
REMARK   3      T13:  -0.1108 T23:  -0.0310                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.1962 L22:   0.6495                                     
REMARK   3      L33:   1.6958 L12:  -0.8637                                     
REMARK   3      L13:  -0.1389 L23:   0.3189                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0394 S12:  -0.0014 S13:  -0.2718                       
REMARK   3      S21:   0.3927 S22:   0.2361 S23:  -0.2442                       
REMARK   3      S31:   0.4777 S32:   0.1096 S33:  -0.2020                       
REMARK   3   TLS GROUP : 18                                                     
REMARK   3    SELECTION: (chain C and resid 130:142)                            
REMARK   3    ORIGIN FOR THE GROUP (A): -30.8203 -10.1870  -5.3135              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4941 T22:   0.6983                                     
REMARK   3      T33:   0.7714 T12:   0.0878                                     
REMARK   3      T13:  -0.1022 T23:  -0.2731                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2239 L22:   8.0350                                     
REMARK   3      L33:   0.8507 L12:  -1.1844                                     
REMARK   3      L13:   0.3481 L23:  -1.0819                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2412 S12:  -1.0450 S13:   0.1580                       
REMARK   3      S21:  -0.6261 S22:   0.9142 S23:  -0.0323                       
REMARK   3      S31:   0.0739 S32:  -0.0442 S33:  -0.5649                       
REMARK   3   TLS GROUP : 19                                                     
REMARK   3    SELECTION: (chain C and resid 143:205)                            
REMARK   3    ORIGIN FOR THE GROUP (A): -18.9212  -5.3249   5.5919              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4200 T22:   0.2632                                     
REMARK   3      T33:   0.2334 T12:   0.0481                                     
REMARK   3      T13:   0.0508 T23:   0.0904                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.0352 L22:   3.2018                                     
REMARK   3      L33:   2.1192 L12:  -0.5082                                     
REMARK   3      L13:  -0.4928 L23:  -0.0256                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2148 S12:  -0.5635 S13:  -0.0502                       
REMARK   3      S21:   1.1280 S22:   0.4886 S23:   0.0712                       
REMARK   3      S31:   0.3077 S32:  -0.2613 S33:  -0.1607                       
REMARK   3   TLS GROUP : 20                                                     
REMARK   3    SELECTION: (chain C and resid 206:267)                            
REMARK   3    ORIGIN FOR THE GROUP (A): -17.2861  11.2995  -4.2757              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1743 T22:   0.1155                                     
REMARK   3      T33:   0.0627 T12:   0.0373                                     
REMARK   3      T13:  -0.0063 T23:  -0.0229                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.7350 L22:   1.8206                                     
REMARK   3      L33:   0.5938 L12:  -0.3778                                     
REMARK   3      L13:   0.6158 L23:  -0.5144                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1094 S12:   0.1250 S13:  -0.0349                       
REMARK   3      S21:  -0.0066 S22:   0.0746 S23:  -0.0267                       
REMARK   3      S31:   0.1128 S32:   0.0642 S33:   0.0218                       
REMARK   3   TLS GROUP : 21                                                     
REMARK   3    SELECTION: (chain C and resid 268:338)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -9.2092  -2.7176 -13.8132              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2188 T22:   0.2001                                     
REMARK   3      T33:   0.2185 T12:   0.0785                                     
REMARK   3      T13:  -0.0148 T23:  -0.0542                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6093 L22:   1.4881                                     
REMARK   3      L33:   1.1556 L12:   0.0158                                     
REMARK   3      L13:   0.8462 L23:  -0.0149                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1248 S12:   0.1623 S13:  -0.1041                       
REMARK   3      S21:  -0.0781 S22:   0.1350 S23:  -0.0467                       
REMARK   3      S31:   0.2491 S32:   0.1656 S33:  -0.2144                       
REMARK   3   TLS GROUP : 22                                                     
REMARK   3    SELECTION: (chain D and resid 1:66)                               
REMARK   3    ORIGIN FOR THE GROUP (A):  40.4940 -60.8126  39.2146              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2917 T22:   0.2010                                     
REMARK   3      T33:   0.2621 T12:   0.0001                                     
REMARK   3      T13:  -0.0111 T23:   0.1031                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.4639 L22:   0.8114                                     
REMARK   3      L33:   1.4013 L12:   0.5459                                     
REMARK   3      L13:   0.3862 L23:  -0.1186                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1558 S12:   0.0020 S13:   0.0200                       
REMARK   3      S21:   0.2031 S22:  -0.0280 S23:  -0.1554                       
REMARK   3      S31:   0.0548 S32:  -0.0289 S33:  -0.0815                       
REMARK   3   TLS GROUP : 23                                                     
REMARK   3    SELECTION: (chain D and resid 67:125)                             
REMARK   3    ORIGIN FOR THE GROUP (A):   2.0426 -40.8117  32.6247              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1761 T22:   0.3187                                     
REMARK   3      T33:   0.1894 T12:   0.0513                                     
REMARK   3      T13:   0.2061 T23:   0.0591                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.9586 L22:   1.7348                                     
REMARK   3      L33:   1.5431 L12:   0.0642                                     
REMARK   3      L13:   0.1701 L23:  -0.6190                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3526 S12:  -0.4082 S13:  -0.0478                       
REMARK   3      S21:   0.7061 S22:   0.5547 S23:   0.5887                       
REMARK   3      S31:  -0.1825 S32:  -0.4067 S33:  -0.2456                       
REMARK   3   TLS GROUP : 24                                                     
REMARK   3    SELECTION: (chain D and resid 126:140)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  12.9951 -22.5637  27.5363              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4844 T22:   0.4326                                     
REMARK   3      T33:   0.4115 T12:  -0.0830                                     
REMARK   3      T13:  -0.0836 T23:   0.1616                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.8184 L22:   2.6667                                     
REMARK   3      L33:   2.1610 L12:   3.1794                                     
REMARK   3      L13:  -0.6957 L23:  -0.4279                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2830 S12:  -0.0120 S13:   0.2476                       
REMARK   3      S21:  -0.4492 S22:  -0.3919 S23:  -0.0717                       
REMARK   3      S31:  -0.3929 S32:   0.5232 S33:   0.5016                       
REMARK   3   TLS GROUP : 25                                                     
REMARK   3    SELECTION: (chain D and resid 141:182)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   4.0681 -27.7129  37.4271              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4825 T22:   0.3678                                     
REMARK   3      T33:   0.2548 T12:   0.1802                                     
REMARK   3      T13:   0.1259 T23:  -0.0917                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.0342 L22:   1.2031                                     
REMARK   3      L33:   0.4654 L12:  -0.1774                                     
REMARK   3      L13:   0.2393 L23:  -0.7813                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2225 S12:  -0.4343 S13:  -0.0599                       
REMARK   3      S21:   1.0184 S22:   0.1692 S23:   0.1659                       
REMARK   3      S31:  -0.1432 S32:  -0.0773 S33:  -0.0060                       
REMARK   3   TLS GROUP : 26                                                     
REMARK   3    SELECTION: (chain D and resid 183:232)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  17.7620 -40.6966  36.9408              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5094 T22:   0.3489                                     
REMARK   3      T33:   0.1576 T12:   0.1116                                     
REMARK   3      T13:  -0.0108 T23:  -0.0179                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.8745 L22:   1.7655                                     
REMARK   3      L33:   0.7221 L12:  -0.8239                                     
REMARK   3      L13:   0.8824 L23:   0.3336                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2910 S12:  -0.6334 S13:   0.1490                       
REMARK   3      S21:   0.9039 S22:   0.4332 S23:  -0.0798                       
REMARK   3      S31:  -0.1918 S32:  -0.2447 S33:  -0.0375                       
REMARK   3   TLS GROUP : 27                                                     
REMARK   3    SELECTION: (chain D and resid 233:274)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  13.8100 -45.0504  23.2688              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1786 T22:   0.1633                                     
REMARK   3      T33:   0.1223 T12:  -0.0141                                     
REMARK   3      T13:   0.0332 T23:  -0.0232                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.8226 L22:   1.2162                                     
REMARK   3      L33:   0.6618 L12:  -0.6165                                     
REMARK   3      L13:   0.3690 L23:   0.3781                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0643 S12:  -0.0029 S13:   0.0780                       
REMARK   3      S21:   0.0678 S22:   0.0196 S23:   0.1364                       
REMARK   3      S31:  -0.1453 S32:  -0.0792 S33:   0.0081                       
REMARK   3   TLS GROUP : 28                                                     
REMARK   3    SELECTION: (chain D and resid 275:338)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   0.3648 -39.1465  18.8913              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0695 T22:   0.2684                                     
REMARK   3      T33:   0.1954 T12:   0.0144                                     
REMARK   3      T13:   0.0314 T23:   0.0353                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.4226 L22:   4.3481                                     
REMARK   3      L33:   1.7060 L12:  -0.5220                                     
REMARK   3      L13:  -1.2245 L23:  -0.8496                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0135 S12:   0.1300 S13:   0.0582                       
REMARK   3      S21:  -0.3336 S22:   0.2318 S23:   0.5712                       
REMARK   3      S31:   0.0311 S32:  -0.2546 S33:  -0.1906                       
REMARK   3   TLS GROUP : 29                                                     
REMARK   3    SELECTION: (chain E and resid 1:67)                               
REMARK   3    ORIGIN FOR THE GROUP (A):  13.0178 -19.1468   4.9205              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0793 T22:   0.1207                                     
REMARK   3      T33:   0.0441 T12:  -0.0119                                     
REMARK   3      T13:  -0.0211 T23:   0.0360                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.9711 L22:   3.0716                                     
REMARK   3      L33:   0.9634 L12:   0.1198                                     
REMARK   3      L13:   0.1424 L23:   0.4667                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0923 S12:  -0.0105 S13:   0.1545                       
REMARK   3      S21:   0.0876 S22:  -0.0109 S23:   0.2290                       
REMARK   3      S31:   0.1778 S32:  -0.3183 S33:  -0.0971                       
REMARK   3   TLS GROUP : 30                                                     
REMARK   3    SELECTION: (chain E and resid 68:82)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  36.9065 -15.2852  18.0884              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4829 T22:   0.1836                                     
REMARK   3      T33:   0.3607 T12:  -0.0981                                     
REMARK   3      T13:  -0.1573 T23:  -0.0331                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.8123 L22:   1.3682                                     
REMARK   3      L33:   3.5803 L12:  -2.6188                                     
REMARK   3      L13:   3.2391 L23:  -2.0567                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0940 S12:  -0.1044 S13:   1.0813                       
REMARK   3      S21:   0.2675 S22:  -0.4485 S23:  -0.6994                       
REMARK   3      S31:  -1.1085 S32:   0.4745 S33:   0.6868                       
REMARK   3   TLS GROUP : 31                                                     
REMARK   3    SELECTION: (chain E and resid 83:136)                             
REMARK   3    ORIGIN FOR THE GROUP (A):  47.7125 -30.5246  39.3035              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2770 T22:   0.2561                                     
REMARK   3      T33:   0.2498 T12:  -0.0602                                     
REMARK   3      T13:  -0.1703 T23:  -0.0240                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.5657 L22:   0.9092                                     
REMARK   3      L33:   0.9275 L12:  -0.5310                                     
REMARK   3      L13:   0.2797 L23:  -0.2518                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1268 S12:  -0.3205 S13:  -0.0709                       
REMARK   3      S21:   0.1104 S22:  -0.0165 S23:   0.0121                       
REMARK   3      S31:  -0.0871 S32:   0.0934 S33:   0.1219                       
REMARK   3   TLS GROUP : 32                                                     
REMARK   3    SELECTION: (chain E and resid 137:182)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  39.8842 -27.5294  45.3304              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4063 T22:   0.3143                                     
REMARK   3      T33:   0.2526 T12:   0.0285                                     
REMARK   3      T13:  -0.1171 T23:  -0.0759                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.8606 L22:   0.3205                                     
REMARK   3      L33:   1.1760 L12:  -0.3404                                     
REMARK   3      L13:  -0.3483 L23:   0.0579                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2998 S12:  -0.2660 S13:   0.0969                       
REMARK   3      S21:   0.2782 S22:   0.0579 S23:   0.2212                       
REMARK   3      S31:  -0.2774 S32:  -0.1280 S33:   0.1573                       
REMARK   3   TLS GROUP : 33                                                     
REMARK   3    SELECTION: (chain E and resid 183:208)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  30.6135 -24.8734  33.1309              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3223 T22:   0.3786                                     
REMARK   3      T33:   0.4180 T12:   0.0660                                     
REMARK   3      T13:  -0.0787 T23:  -0.1058                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0977 L22:   4.6071                                     
REMARK   3      L33:   2.0125 L12:  -0.6727                                     
REMARK   3      L13:  -0.2640 L23:   2.4438                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2048 S12:  -0.4008 S13:   0.2608                       
REMARK   3      S21:   0.4668 S22:  -0.3075 S23:   0.6515                       
REMARK   3      S31:  -0.0968 S32:  -0.5721 S33:   0.3442                       
REMARK   3   TLS GROUP : 34                                                     
REMARK   3    SELECTION: (chain E and resid 209:267)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  35.2266 -29.4192  22.1872              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1847 T22:   0.1187                                     
REMARK   3      T33:   0.1282 T12:  -0.0005                                     
REMARK   3      T13:  -0.0372 T23:  -0.0032                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3659 L22:   1.3841                                     
REMARK   3      L33:   2.5204 L12:  -0.3793                                     
REMARK   3      L13:   0.7100 L23:   0.3116                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1703 S12:  -0.0269 S13:   0.0520                       
REMARK   3      S21:   0.2699 S22:   0.0195 S23:   0.1069                       
REMARK   3      S31:  -0.1255 S32:   0.0455 S33:   0.1536                       
REMARK   3   TLS GROUP : 35                                                     
REMARK   3    SELECTION: (chain E and resid 268:338)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  50.8763 -38.0281  29.9084              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0903 T22:   0.1492                                     
REMARK   3      T33:   0.1890 T12:  -0.0080                                     
REMARK   3      T13:  -0.0739 T23:   0.0406                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.8793 L22:   1.6411                                     
REMARK   3      L33:   3.2811 L12:   0.7482                                     
REMARK   3      L13:   0.7647 L23:  -0.7971                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0074 S12:  -0.0191 S13:  -0.0339                       
REMARK   3      S21:  -0.0089 S22:  -0.1291 S23:  -0.3643                       
REMARK   3      S31:   0.2653 S32:   0.3981 S33:   0.0772                       
REMARK   3   TLS GROUP : 36                                                     
REMARK   3    SELECTION: (chain F and resid 1:67)                               
REMARK   3    ORIGIN FOR THE GROUP (A):  -2.9335  32.0197  23.6332              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1585 T22:   0.1253                                     
REMARK   3      T33:   0.1580 T12:  -0.0263                                     
REMARK   3      T13:  -0.0155 T23:   0.0039                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.3069 L22:   0.4272                                     
REMARK   3      L33:   2.6845 L12:  -0.6460                                     
REMARK   3      L13:   0.6452 L23:  -0.1799                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0124 S12:   0.0472 S13:  -0.1059                       
REMARK   3      S21:  -0.0284 S22:  -0.0679 S23:  -0.0088                       
REMARK   3      S31:   0.0360 S32:   0.1007 S33:   0.0378                       
REMARK   3   TLS GROUP : 37                                                     
REMARK   3    SELECTION: (chain F and resid 68:125)                             
REMARK   3    ORIGIN FOR THE GROUP (A): -40.3335  12.8940  36.6199              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1380 T22:   0.2470                                     
REMARK   3      T33:   0.3768 T12:  -0.0255                                     
REMARK   3      T13:  -0.1133 T23:  -0.0041                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.5279 L22:   0.7599                                     
REMARK   3      L33:   1.4051 L12:   0.2067                                     
REMARK   3      L13:   0.7172 L23:   0.4194                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0670 S12:   0.1889 S13:  -0.3673                       
REMARK   3      S21:  -0.2816 S22:   0.1442 S23:   0.3823                       
REMARK   3      S31:  -0.0448 S32:  -0.2300 S33:  -0.1135                       
REMARK   3   TLS GROUP : 38                                                     
REMARK   3    SELECTION: (chain F and resid 126:143)                            
REMARK   3    ORIGIN FOR THE GROUP (A): -29.0055  -5.0262  43.9900              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1521 T22:   0.4135                                     
REMARK   3      T33:   0.3946 T12:  -0.0292                                     
REMARK   3      T13:  -0.0236 T23:  -0.0621                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1231 L22:   1.0729                                     
REMARK   3      L33:   2.3280 L12:  -0.3072                                     
REMARK   3      L13:   0.1308 L23:  -0.1696                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2498 S12:  -0.0346 S13:   0.4261                       
REMARK   3      S21:   0.2613 S22:   0.0846 S23:  -0.0554                       
REMARK   3      S31:   0.2450 S32:   0.5972 S33:  -0.2538                       
REMARK   3   TLS GROUP : 39                                                     
REMARK   3    SELECTION: (chain F and resid 144:236)                            
REMARK   3    ORIGIN FOR THE GROUP (A): -30.6865   6.9237  32.6398              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1752 T22:   0.1820                                     
REMARK   3      T33:   0.3048 T12:  -0.0746                                     
REMARK   3      T13:  -0.0667 T23:  -0.0681                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.5717 L22:   0.3971                                     
REMARK   3      L33:   0.9131 L12:  -0.3978                                     
REMARK   3      L13:   0.0059 L23:   0.1241                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0047 S12:   0.3270 S13:  -0.4008                       
REMARK   3      S21:  -0.3136 S22:   0.1494 S23:  -0.0434                       
REMARK   3      S31:   0.1123 S32:   0.0846 S33:  -0.1724                       
REMARK   3   TLS GROUP : 40                                                     
REMARK   3    SELECTION: (chain F and resid 237:249)                            
REMARK   3    ORIGIN FOR THE GROUP (A): -20.8629  15.5458  52.0485              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3087 T22:   0.2015                                     
REMARK   3      T33:   0.3276 T12:  -0.0305                                     
REMARK   3      T13:   0.0286 T23:  -0.0773                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.5505 L22:   4.1647                                     
REMARK   3      L33:   7.6808 L12:   2.9947                                     
REMARK   3      L13:   1.1840 L23:   3.1200                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3344 S12:   0.1383 S13:  -0.0145                       
REMARK   3      S21:   0.4669 S22:  -0.6071 S23:   0.8314                       
REMARK   3      S31:   1.1050 S32:  -0.7497 S33:   0.1816                       
REMARK   3   TLS GROUP : 41                                                     
REMARK   3    SELECTION: (chain F and resid 250:269)                            
REMARK   3    ORIGIN FOR THE GROUP (A): -30.3058  23.5513  38.8179              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1208 T22:   0.1290                                     
REMARK   3      T33:   0.1853 T12:  -0.0122                                     
REMARK   3      T13:  -0.0244 T23:  -0.0110                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.8409 L22:   0.8056                                     
REMARK   3      L33:   1.8270 L12:  -0.3444                                     
REMARK   3      L13:   1.8025 L23:   0.3188                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3438 S12:  -0.3047 S13:   0.0185                       
REMARK   3      S21:  -0.0431 S22:   0.1070 S23:   0.1151                       
REMARK   3      S31:  -0.2216 S32:  -0.2216 S33:   0.2170                       
REMARK   3   TLS GROUP : 42                                                     
REMARK   3    SELECTION: (chain F and resid 270:338)                            
REMARK   3    ORIGIN FOR THE GROUP (A): -39.9443  13.9783  50.6449              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0992 T22:   0.2210                                     
REMARK   3      T33:   0.3463 T12:  -0.0014                                     
REMARK   3      T13:   0.0168 T23:   0.0884                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.3679 L22:   2.4659                                     
REMARK   3      L33:   1.4154 L12:   0.4856                                     
REMARK   3      L13:   0.3178 L23:  -0.8043                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1064 S12:  -0.3230 S13:  -0.2582                       
REMARK   3      S21:   0.2677 S22:   0.0980 S23:   0.6048                       
REMARK   3      S31:  -0.0741 S32:  -0.2112 S33:  -0.2372                       
REMARK   3   TLS GROUP : 43                                                     
REMARK   3    SELECTION: (chain G and resid 1:65)                               
REMARK   3    ORIGIN FOR THE GROUP (A):   4.4927 -57.9088  57.4341              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2332 T22:   0.1704                                     
REMARK   3      T33:   0.1899 T12:  -0.0283                                     
REMARK   3      T13:   0.1196 T23:  -0.0769                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.7088 L22:   0.9349                                     
REMARK   3      L33:   2.1832 L12:   0.4712                                     
REMARK   3      L13:  -0.1589 L23:   0.6643                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0934 S12:   0.1753 S13:   0.0065                       
REMARK   3      S21:  -0.2144 S22:   0.0259 S23:   0.0802                       
REMARK   3      S31:  -0.1397 S32:  -0.2297 S33:  -0.0860                       
REMARK   3   TLS GROUP : 44                                                     
REMARK   3    SELECTION: (chain G and resid 66:91)                              
REMARK   3    ORIGIN FOR THE GROUP (A):  26.0886 -33.4394  60.5885              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4404 T22:   0.3451                                     
REMARK   3      T33:   0.2999 T12:  -0.1523                                     
REMARK   3      T13:   0.1761 T23:  -0.0736                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3343 L22:   2.6552                                     
REMARK   3      L33:   0.8344 L12:   0.5181                                     
REMARK   3      L13:  -0.2758 L23:  -0.8718                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2195 S12:   0.2138 S13:  -0.0548                       
REMARK   3      S21:  -1.1490 S22:   0.1320 S23:  -0.4784                       
REMARK   3      S31:   0.0205 S32:   0.1813 S33:   0.0166                       
REMARK   3   TLS GROUP : 45                                                     
REMARK   3    SELECTION: (chain G and resid 92:131)                             
REMARK   3    ORIGIN FOR THE GROUP (A):  24.8942 -12.2579  75.4021              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2086 T22:   0.1256                                     
REMARK   3      T33:   0.1440 T12:  -0.1051                                     
REMARK   3      T13:  -0.0038 T23:   0.0042                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.2677 L22:   0.8864                                     
REMARK   3      L33:   2.1585 L12:   0.7770                                     
REMARK   3      L13:   1.0525 L23:   1.2465                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3970 S12:  -0.1622 S13:   0.1626                       
REMARK   3      S21:  -0.6459 S22:   0.3438 S23:   0.0946                       
REMARK   3      S31:  -0.8132 S32:   0.0104 S33:   0.0363                       
REMARK   3   TLS GROUP : 46                                                     
REMARK   3    SELECTION: (chain G and resid 132:158)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  14.8513  -7.7186  72.5864              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3772 T22:   0.2627                                     
REMARK   3      T33:   0.3540 T12:  -0.0740                                     
REMARK   3      T13:  -0.0525 T23:   0.0020                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.7969 L22:   2.2105                                     
REMARK   3      L33:   2.8179 L12:  -0.7437                                     
REMARK   3      L13:   0.4263 L23:   1.0589                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0798 S12:   0.5146 S13:  -0.1390                       
REMARK   3      S21:  -0.3384 S22:  -0.3073 S23:   0.4973                       
REMARK   3      S31:  -0.4173 S32:  -0.5945 S33:   0.3071                       
REMARK   3   TLS GROUP : 47                                                     
REMARK   3    SELECTION: (chain G and resid 159:205)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  13.7530 -19.2993  63.8329              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3777 T22:   0.3066                                     
REMARK   3      T33:   0.2519 T12:  -0.1126                                     
REMARK   3      T13:  -0.1082 T23:   0.0790                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.0428 L22:   2.0232                                     
REMARK   3      L33:   0.5600 L12:   0.2240                                     
REMARK   3      L13:   0.5820 L23:   0.5428                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2623 S12:   0.4855 S13:  -0.0482                       
REMARK   3      S21:  -0.6338 S22:   0.3470 S23:   0.2739                       
REMARK   3      S31:  -0.1708 S32:  -0.1542 S33:  -0.0751                       
REMARK   3   TLS GROUP : 48                                                     
REMARK   3    SELECTION: (chain G and resid 206:267)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  17.3007 -33.4791  71.3711              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1645 T22:   0.1782                                     
REMARK   3      T33:   0.1358 T12:  -0.0707                                     
REMARK   3      T13:   0.0162 T23:  -0.0289                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.5376 L22:   2.4677                                     
REMARK   3      L33:   1.2649 L12:  -0.4651                                     
REMARK   3      L13:  -0.7641 L23:  -0.1178                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1065 S12:   0.1160 S13:  -0.0891                       
REMARK   3      S21:  -0.2423 S22:   0.2312 S23:  -0.0623                       
REMARK   3      S31:  -0.0126 S32:  -0.2266 S33:  -0.1005                       
REMARK   3   TLS GROUP : 49                                                     
REMARK   3    SELECTION: (chain G and resid 268:338)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  27.0824 -21.5029  83.2034              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1501 T22:   0.1845                                     
REMARK   3      T33:   0.1630 T12:  -0.0595                                     
REMARK   3      T13:  -0.0198 T23:  -0.0283                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.0410 L22:   2.5149                                     
REMARK   3      L33:   0.6635 L12:  -0.0914                                     
REMARK   3      L13:  -0.7204 L23:   0.4483                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0051 S12:  -0.1949 S13:   0.0874                       
REMARK   3      S21:   0.0574 S22:   0.1420 S23:  -0.0802                       
REMARK   3      S31:  -0.0988 S32:   0.0800 S33:  -0.1157                       
REMARK   3   TLS GROUP : 50                                                     
REMARK   3    SELECTION: (chain H and resid 1:66)                               
REMARK   3    ORIGIN FOR THE GROUP (A):  51.3894 -11.9897 -28.2103              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3588 T22:   0.3408                                     
REMARK   3      T33:   0.2885 T12:   0.0060                                     
REMARK   3      T13:  -0.0593 T23:  -0.0572                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.7569 L22:   1.6289                                     
REMARK   3      L33:   0.7448 L12:   0.6958                                     
REMARK   3      L13:   0.1954 L23:   0.6476                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2363 S12:  -0.1147 S13:  -0.2279                       
REMARK   3      S21:  -0.0192 S22:   0.0341 S23:  -0.1214                       
REMARK   3      S31:   0.3261 S32:  -0.0378 S33:  -0.1927                       
REMARK   3   TLS GROUP : 51                                                     
REMARK   3    SELECTION: (chain H and resid 67:125)                             
REMARK   3    ORIGIN FOR THE GROUP (A):  27.0442  12.9663  -1.6697              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1637 T22:   0.2790                                     
REMARK   3      T33:   0.3001 T12:  -0.0860                                     
REMARK   3      T13:   0.1303 T23:  -0.1053                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.7429 L22:   2.5025                                     
REMARK   3      L33:   2.5120 L12:   0.2323                                     
REMARK   3      L13:  -0.4346 L23:   0.2515                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1999 S12:  -0.0224 S13:   0.1669                       
REMARK   3      S21:   0.3518 S22:  -0.2163 S23:   0.5735                       
REMARK   3      S31:   0.0470 S32:  -0.4619 S33:   0.1160                       
REMARK   3   TLS GROUP : 52                                                     
REMARK   3    SELECTION: (chain H and resid 126:144)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  43.8545  15.9680  12.3846              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9904 T22:   0.4986                                     
REMARK   3      T33:   0.3286 T12:  -0.1734                                     
REMARK   3      T13:  -0.0863 T23:  -0.0543                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.5428 L22:   2.1378                                     
REMARK   3      L33:   1.8701 L12:   1.4733                                     
REMARK   3      L13:  -2.8118 L23:  -0.8704                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1640 S12:  -0.8893 S13:  -0.7431                       
REMARK   3      S21:   1.0642 S22:  -0.3350 S23:  -0.4323                       
REMARK   3      S31:   0.7211 S32:   0.5186 S33:  -0.0081                       
REMARK   3   TLS GROUP : 53                                                     
REMARK   3    SELECTION: (chain H and resid 145:206)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  34.2935   7.0639   6.9097              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4956 T22:   0.3112                                     
REMARK   3      T33:   0.2498 T12:  -0.1522                                     
REMARK   3      T13:   0.0977 T23:  -0.0222                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.4538 L22:   0.7584                                     
REMARK   3      L33:   1.0476 L12:   0.2688                                     
REMARK   3      L13:   0.1065 L23:  -0.2952                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2147 S12:   0.0861 S13:   0.0609                       
REMARK   3      S21:   0.4167 S22:  -0.2226 S23:   0.1331                       
REMARK   3      S31:   0.4344 S32:   0.0386 S33:   0.0371                       
REMARK   3   TLS GROUP : 54                                                     
REMARK   3    SELECTION: (chain H and resid 207:267)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  39.2658   9.8408 -10.9654              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1706 T22:   0.1486                                     
REMARK   3      T33:   0.1998 T12:  -0.0133                                     
REMARK   3      T13:   0.0022 T23:  -0.0200                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.5976 L22:   1.5085                                     
REMARK   3      L33:   1.4376 L12:   1.4659                                     
REMARK   3      L13:  -0.2378 L23:  -0.5930                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0369 S12:   0.0048 S13:  -0.0603                       
REMARK   3      S21:   0.1836 S22:  -0.0887 S23:  -0.0216                       
REMARK   3      S31:   0.1014 S32:  -0.1561 S33:   0.0903                       
REMARK   3   TLS GROUP : 55                                                     
REMARK   3    SELECTION: (chain H and resid 268:297)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  34.1663  23.6852  -7.9387              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1737 T22:   0.1863                                     
REMARK   3      T33:   0.1987 T12:  -0.0043                                     
REMARK   3      T13:   0.0434 T23:  -0.0835                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.8098 L22:   0.3320                                     
REMARK   3      L33:   1.5233 L12:   0.0378                                     
REMARK   3      L13:  -1.2104 L23:  -0.0188                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0973 S12:  -0.1094 S13:  -0.0766                       
REMARK   3      S21:   0.0979 S22:   0.0156 S23:   0.1009                       
REMARK   3      S31:  -0.2742 S32:   0.2292 S33:  -0.1296                       
REMARK   3   TLS GROUP : 56                                                     
REMARK   3    SELECTION: (chain H and resid 298:338)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  29.6079  27.1168  -1.1270              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2658 T22:   0.2862                                     
REMARK   3      T33:   0.4310 T12:   0.0112                                     
REMARK   3      T13:   0.1211 T23:  -0.1609                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3562 L22:   0.5946                                     
REMARK   3      L33:   3.2485 L12:  -0.0119                                     
REMARK   3      L13:  -0.8976 L23:  -0.2225                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2580 S12:  -0.1563 S13:   0.2464                       
REMARK   3      S21:   0.2270 S22:  -0.0544 S23:   0.4676                       
REMARK   3      S31:  -0.7763 S32:  -0.4156 S33:  -0.1987                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 3PG9 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 16-NOV-10.                  
REMARK 100 THE RCSB ID CODE IS RCSB062340.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 24-JUL-10                          
REMARK 200  TEMPERATURE           (KELVIN) : 110                                
REMARK 200  PH                             : NULL                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : AUSTRALIAN SYNCHROTRON             
REMARK 200  BEAMLINE                       : MX2                                
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9537                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : AREA DETECTOR                      
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315R                  
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM                             
REMARK 200  DATA SCALING SOFTWARE          : SCALA                              
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 104678                             
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.350                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 52.567                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 97.4                               
REMARK 200  DATA REDUNDANCY                : 3.000                              
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : 0.10200                            
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : NULL                               
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.35                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.48                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 98.6                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 3.00                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.52800                            
REMARK 200  R SYM FOR SHELL            (I) : 0.52800                            
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 1.400                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: NULL                                                  
REMARK 200 STARTING MODEL: 1VR6                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 44.03                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.20                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 20%(W/V) POLYETHYLENE GLYCOL 3350,       
REMARK 280  0.2M AMMONIUM NITRATE, 0.02%(W/V) SODIUM AZIDE, VAPOR DIFFUSION,    
REMARK 280  HANGING DROP, TEMPERATURE 293.15K                                   
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y+1/2,-Z                                             
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000       60.50100            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 15930 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 44590 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -73.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, F, G                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 15560 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 44750 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -73.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D, E, H                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     GLU A  12    CD   OE1  OE2                                       
REMARK 470     ARG A  15    CD   NE   CZ   NH1  NH2                             
REMARK 470     LYS A  19    CG   CD   CE   NZ                                   
REMARK 470     ASN A  25    OD1  ND2                                            
REMARK 470     LYS A  52    CE   NZ                                             
REMARK 470     ASP A  57    OD1  OD2                                            
REMARK 470     GLU A  79    CG   CD   OE1  OE2                                  
REMARK 470     LYS A  89    CD   CE   NZ                                        
REMARK 470     ASN A  92    CG   OD1  ND2                                       
REMARK 470     GLU A 108    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 112    OE1  OE2                                            
REMARK 470     LYS A 131    CG   CD   CE   NZ                                   
REMARK 470     ARG A 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR A 134    OG1  CG2                                            
REMARK 470     SER A 135    OG                                                  
REMARK 470     TYR A 137    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     SER A 138    OG                                                  
REMARK 470     GLN A 140    CG   CD   OE1  NE2                                  
REMARK 470     LYS A 145    NZ                                                  
REMARK 470     ARG A 186    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 192    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 196    CD   CE   NZ                                        
REMARK 470     ARG A 247    CZ   NH1  NH2                                       
REMARK 470     LYS A 305    CD   CE   NZ                                        
REMARK 470     LYS A 320    CE   NZ                                             
REMARK 470     LYS A 328    CG   CD   CE   NZ                                   
REMARK 470     LYS A 336    CE   NZ                                             
REMARK 470     GLU B  12    CG   CD   OE1  OE2                                  
REMARK 470     LYS B  16    CE   NZ                                             
REMARK 470     LYS B  19    CG   CD   CE   NZ                                   
REMARK 470     ASN B  25    OD1  ND2                                            
REMARK 470     LYS B  27    CG   CD   CE   NZ                                   
REMARK 470     LYS B  52    CG   CD   CE   NZ                                   
REMARK 470     LYS B  67    NZ                                                  
REMARK 470     LYS B  70    NZ                                                  
REMARK 470     GLU B  79    CD   OE1  OE2                                       
REMARK 470     LYS B 131    CD   CE   NZ                                        
REMARK 470     ARG B 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN B 140    CG   CD   OE1  NE2                                  
REMARK 470     ARG B 186    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS B 244    CD   CE   NZ                                        
REMARK 470     ARG B 247    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU B 261    OE1  OE2                                            
REMARK 470     GLU B 317    CG   CD   OE1  OE2                                  
REMARK 470     LYS B 320    CE   NZ                                             
REMARK 470     LYS C  16    CE   NZ                                             
REMARK 470     LYS C  19    CG   CD   CE   NZ                                   
REMARK 470     ASP C  51    OD1  OD2                                            
REMARK 470     LYS C  52    CG   CD   CE   NZ                                   
REMARK 470     ASP C  57    CG   OD1  OD2                                       
REMARK 470     GLU C  79    OE1  OE2                                            
REMARK 470     ASN C  92    CG   OD1  ND2                                       
REMARK 470     GLU C 108    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 123    CD   CE   NZ                                        
REMARK 470     LYS C 131    CG   CD   CE   NZ                                   
REMARK 470     ARG C 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR C 134    OG1  CG2                                            
REMARK 470     TYR C 137    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     SER C 138    OG                                                  
REMARK 470     GLN C 140    CG   CD   OE1  NE2                                  
REMARK 470     LEU C 142    CG   CD1  CD2                                       
REMARK 470     LYS C 156    NZ                                                  
REMARK 470     LYS C 173    CG   CD   CE   NZ                                   
REMARK 470     ILE C 181    CD1                                                 
REMARK 470     ARG C 186    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG C 192    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER C 195    OG                                                  
REMARK 470     LYS C 196    CG   CD   CE   NZ                                   
REMARK 470     TYR C 223    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ARG C 247    NH1  NH2                                            
REMARK 470     GLU C 302    OE1  OE2                                            
REMARK 470     GLU C 304    OE1  OE2                                            
REMARK 470     LYS C 305    CE   NZ                                             
REMARK 470     GLN C 324    CG   CD   OE1  NE2                                  
REMARK 470     LYS C 328    CE   NZ                                             
REMARK 470     LYS D  19    CG   CD   CE   NZ                                   
REMARK 470     LYS D  27    CG   CD   CE   NZ                                   
REMARK 470     ASP D  51    OD1  OD2                                            
REMARK 470     LYS D  67    NZ                                                  
REMARK 470     LYS D  70    CE   NZ                                             
REMARK 470     ASP D  87    OD1  OD2                                            
REMARK 470     LYS D  89    CD   CE   NZ                                        
REMARK 470     ASN D  92    CG   OD1  ND2                                       
REMARK 470     LYS D 123    CG   CD   CE   NZ                                   
REMARK 470     LYS D 131    CG   CD   CE   NZ                                   
REMARK 470     ARG D 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR D 134    OG1  CG2                                            
REMARK 470     TYR D 137    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     SER D 138    OG                                                  
REMARK 470     PHE D 139    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN D 140    CG   CD   OE1  NE2                                  
REMARK 470     LYS D 145    CD   CE   NZ                                        
REMARK 470     LYS D 156    NZ                                                  
REMARK 470     LYS D 173    CG   CD   CE   NZ                                   
REMARK 470     ARG D 186    NH1  NH2                                            
REMARK 470     LYS D 196    CG   CD   CE   NZ                                   
REMARK 470     LYS D 231    CE   NZ                                             
REMARK 470     LYS D 244    CG   CD   CE   NZ                                   
REMARK 470     ARG D 247    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS D 260    CD   CE   NZ                                        
REMARK 470     GLU D 261    OE1  OE2                                            
REMARK 470     LYS D 305    CG   CD   CE   NZ                                   
REMARK 470     GLU D 317    CG   CD   OE1  OE2                                  
REMARK 470     LYS D 320    CE   NZ                                             
REMARK 470     GLN D 324    OE1  NE2                                            
REMARK 470     LYS D 327    NZ                                                  
REMARK 470     LYS D 328    CD   CE   NZ                                        
REMARK 470     LYS D 336    NZ                                                  
REMARK 470     LYS E  16    CE   NZ                                             
REMARK 470     LYS E  19    CG   CD   CE   NZ                                   
REMARK 470     GLU E  22    CD   OE1  OE2                                       
REMARK 470     LYS E  70    NZ                                                  
REMARK 470     LYS E 131    CG   CD   CE   NZ                                   
REMARK 470     ARG E 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR E 134    OG1  CG2                                            
REMARK 470     TYR E 137    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     SER E 138    OG                                                  
REMARK 470     GLN E 140    CG   CD   OE1  NE2                                  
REMARK 470     LYS E 244    CD   CE   NZ                                        
REMARK 470     ARG E 247    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS E 311    NZ                                                  
REMARK 470     LYS E 320    CG   CD   CE   NZ                                   
REMARK 470     LYS E 336    CE   NZ                                             
REMARK 470     LYS F  19    CG   CD   CE   NZ                                   
REMARK 470     ASP F  51    OD1  OD2                                            
REMARK 470     GLU F 119    CG   CD   OE1  OE2                                  
REMARK 470     ARG F 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR F 137    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS F 145    CD   CE   NZ                                        
REMARK 470     ARG F 247    CB   CG   CD   NE   CZ   NH1  NH2                   
REMARK 470     LYS F 260    CE   NZ                                             
REMARK 470     LYS F 305    CG   CD   CE   NZ                                   
REMARK 470     LEU F 307    CG   CD1  CD2                                       
REMARK 470     GLU F 317    OE1  OE2                                            
REMARK 470     LYS F 320    CE   NZ                                             
REMARK 470     LYS F 336    CE   NZ                                             
REMARK 470     LYS G  19    CG   CD   CE   NZ                                   
REMARK 470     LYS G  27    CG   CD   CE   NZ                                   
REMARK 470     LYS G  70    CE   NZ                                             
REMARK 470     GLU G  79    CD   OE1  OE2                                       
REMARK 470     LYS G  89    NZ                                                  
REMARK 470     ASN G  92    CG   OD1  ND2                                       
REMARK 470     LYS G 123    NZ                                                  
REMARK 470     LYS G 131    CG   CD   CE   NZ                                   
REMARK 470     ARG G 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR G 137    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS G 156    NZ                                                  
REMARK 470     ARG G 186    NE   CZ   NH1  NH2                                  
REMARK 470     SER G 195    OG                                                  
REMARK 470     LYS G 196    CG   CD   CE   NZ                                   
REMARK 470     LYS G 260    CD   CE   NZ                                        
REMARK 470     LYS G 311    NZ                                                  
REMARK 470     ASP G 331    OD1  OD2                                            
REMARK 470     LYS G 336    CD   CE   NZ                                        
REMARK 470     GLU H  12    CG   CD   OE1  OE2                                  
REMARK 470     LYS H  19    CG   CD   CE   NZ                                   
REMARK 470     GLU H  22    CG   CD   OE1  OE2                                  
REMARK 470     LYS H  27    CE   NZ                                             
REMARK 470     ASP H  57    CG   OD1  OD2                                       
REMARK 470     LYS H  70    CG   CD   CE   NZ                                   
REMARK 470     GLU H  79    CD   OE1  OE2                                       
REMARK 470     LYS H  89    CE   NZ                                             
REMARK 470     GLU H 108    CG   CD   OE1  OE2                                  
REMARK 470     LYS H 123    CD   CE   NZ                                        
REMARK 470     ARG H 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER H 135    OG                                                  
REMARK 470     TYR H 137    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN H 140    CG   CD   OE1  NE2                                  
REMARK 470     LYS H 145    CG   CD   CE   NZ                                   
REMARK 470     LYS H 156    CG   CD   CE   NZ                                   
REMARK 470     GLU H 168    CG   CD   OE1  OE2                                  
REMARK 470     ASP H 169    OD1  OD2                                            
REMARK 470     ARG H 186    CZ   NH1  NH2                                       
REMARK 470     LYS H 196    CG   CD   CE   NZ                                   
REMARK 470     ARG H 247    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS H 305    NZ                                                  
REMARK 470     GLU H 317    CG   CD   OE1  OE2                                  
REMARK 470     LYS H 320    CD   CE   NZ                                        
REMARK 470     GLU H 321    OE1  OE2                                            
REMARK 470     LYS H 328    CD   CE   NZ                                        
REMARK 470     ASP H 331    OD2                                                 
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LYS A  70      -48.73   -148.38                                   
REMARK 500    THR A 134       72.57     48.68                                   
REMARK 500    SER A 135      114.72     71.71                                   
REMARK 500    GLN A 189     -155.80    -94.30                                   
REMARK 500    ASN A 190       85.35     86.06                                   
REMARK 500    ARG A 237       19.34   -144.45                                   
REMARK 500    LYS B  70      -54.84   -135.92                                   
REMARK 500    ASN B  92     -130.95     52.59                                   
REMARK 500    ARG B 133       96.63     63.21                                   
REMARK 500    THR B 134      -65.10    -91.83                                   
REMARK 500    LYS C  70      -50.61   -139.80                                   
REMARK 500    ASN C  92      123.18    -36.56                                   
REMARK 500    SER C 135      124.45     60.26                                   
REMARK 500    PRO C 136       10.24    -66.23                                   
REMARK 500    ASN C 187       30.87    -84.13                                   
REMARK 500    LYS D  70      -54.89   -130.91                                   
REMARK 500    ASN D  92      129.10    -32.52                                   
REMARK 500    PRO D 136       76.11    -20.05                                   
REMARK 500    TYR D 137      -30.04   -177.46                                   
REMARK 500    PHE D 139      112.74    -38.88                                   
REMARK 500    SER D 199       25.00    -77.92                                   
REMARK 500    THR D 241     -154.52   -136.24                                   
REMARK 500    ASP D 251       79.54   -102.62                                   
REMARK 500    LYS E  70      -49.28   -140.93                                   
REMARK 500    ARG E 133       62.03   -111.21                                   
REMARK 500    PRO E 136       -6.48    -57.28                                   
REMARK 500    SER E 227       20.55    -78.27                                   
REMARK 500    LYS F  70      -54.93   -130.34                                   
REMARK 500    THR F 134      -49.64   -130.77                                   
REMARK 500    PRO F 136        5.79    -64.84                                   
REMARK 500    THR F 241     -167.15   -124.25                                   
REMARK 500    TYR G  47       31.13    -92.90                                   
REMARK 500    LYS G  70      -48.14   -138.52                                   
REMARK 500    PRO G 132      107.47    -51.45                                   
REMARK 500    THR G 134      -74.33   -145.82                                   
REMARK 500    PRO G 136        3.98    -66.92                                   
REMARK 500    GLU G 302       74.89   -150.38                                   
REMARK 500    ASP H  51      -71.52    -19.51                                   
REMARK 500    LYS H  70      -53.07   -137.82                                   
REMARK 500    ASN H  92      124.67    -33.31                                   
REMARK 500    SER H 135      142.30   -174.15                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE TYR A 339                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE TYR A 340                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AZI A 341                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NO3 A 342                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE TYR B 339                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE TYR B 340                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE AZI B 341                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CL B 342                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE TYR C 339                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE TYR C 340                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NO3 C 341                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE TYR D 339                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NO3 D 340                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NO3 F 339                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE TYR H 339                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 3PG8   RELATED DB: PDB                                   
DBREF  3PG9 A    1   338  UNP    Q9WYH8   AROF_THEMA       1    338             
DBREF  3PG9 B    1   338  UNP    Q9WYH8   AROF_THEMA       1    338             
DBREF  3PG9 C    1   338  UNP    Q9WYH8   AROF_THEMA       1    338             
DBREF  3PG9 D    1   338  UNP    Q9WYH8   AROF_THEMA       1    338             
DBREF  3PG9 E    1   338  UNP    Q9WYH8   AROF_THEMA       1    338             
DBREF  3PG9 F    1   338  UNP    Q9WYH8   AROF_THEMA       1    338             
DBREF  3PG9 G    1   338  UNP    Q9WYH8   AROF_THEMA       1    338             
DBREF  3PG9 H    1   338  UNP    Q9WYH8   AROF_THEMA       1    338             
SEQRES   1 A  338  MET ILE VAL VAL LEU LYS PRO GLY SER THR GLU GLU ASP          
SEQRES   2 A  338  ILE ARG LYS VAL VAL LYS LEU ALA GLU SER TYR ASN LEU          
SEQRES   3 A  338  LYS CYS HIS ILE SER LYS GLY GLN GLU ARG THR VAL ILE          
SEQRES   4 A  338  GLY ILE ILE GLY ASP ASP ARG TYR VAL VAL ALA ASP LYS          
SEQRES   5 A  338  PHE GLU SER LEU ASP CYS VAL GLU SER VAL VAL ARG VAL          
SEQRES   6 A  338  LEU LYS PRO TYR LYS LEU VAL SER ARG GLU PHE HIS PRO          
SEQRES   7 A  338  GLU ASP THR VAL ILE ASP LEU GLY ASP VAL LYS ILE GLY          
SEQRES   8 A  338  ASN GLY TYR PHE THR ILE ILE ALA GLY PRO CYS SER VAL          
SEQRES   9 A  338  GLU GLY ARG GLU MET LEU MET GLU THR ALA HIS PHE LEU          
SEQRES  10 A  338  SER GLU LEU GLY VAL LYS VAL LEU ARG GLY GLY ALA TYR          
SEQRES  11 A  338  LYS PRO ARG THR SER PRO TYR SER PHE GLN GLY LEU GLY          
SEQRES  12 A  338  GLU LYS GLY LEU GLU TYR LEU ARG GLU ALA ALA ASP LYS          
SEQRES  13 A  338  TYR GLY MET TYR VAL VAL THR GLU ALA LEU GLY GLU ASP          
SEQRES  14 A  338  ASP LEU PRO LYS VAL ALA GLU TYR ALA ASP ILE ILE GLN          
SEQRES  15 A  338  ILE GLY ALA ARG ASN ALA GLN ASN PHE ARG LEU LEU SER          
SEQRES  16 A  338  LYS ALA GLY SER TYR ASN LYS PRO VAL LEU LEU LYS ARG          
SEQRES  17 A  338  GLY PHE MET ASN THR ILE GLU GLU PHE LEU LEU SER ALA          
SEQRES  18 A  338  GLU TYR ILE ALA ASN SER GLY ASN THR LYS ILE ILE LEU          
SEQRES  19 A  338  CYS GLU ARG GLY ILE ARG THR PHE GLU LYS ALA THR ARG          
SEQRES  20 A  338  ASN THR LEU ASP ILE SER ALA VAL PRO ILE ILE ARG LYS          
SEQRES  21 A  338  GLU SER HIS LEU PRO ILE LEU VAL ASP PRO SER HIS SER          
SEQRES  22 A  338  GLY GLY ARG ARG ASP LEU VAL ILE PRO LEU SER ARG ALA          
SEQRES  23 A  338  ALA ILE ALA VAL GLY ALA HIS GLY ILE ILE VAL GLU VAL          
SEQRES  24 A  338  HIS PRO GLU PRO GLU LYS ALA LEU SER ASP GLY LYS GLN          
SEQRES  25 A  338  SER LEU ASP PHE GLU LEU PHE LYS GLU LEU VAL GLN GLU          
SEQRES  26 A  338  MET LYS LYS LEU ALA ASP ALA LEU GLY VAL LYS VAL ASN          
SEQRES   1 B  338  MET ILE VAL VAL LEU LYS PRO GLY SER THR GLU GLU ASP          
SEQRES   2 B  338  ILE ARG LYS VAL VAL LYS LEU ALA GLU SER TYR ASN LEU          
SEQRES   3 B  338  LYS CYS HIS ILE SER LYS GLY GLN GLU ARG THR VAL ILE          
SEQRES   4 B  338  GLY ILE ILE GLY ASP ASP ARG TYR VAL VAL ALA ASP LYS          
SEQRES   5 B  338  PHE GLU SER LEU ASP CYS VAL GLU SER VAL VAL ARG VAL          
SEQRES   6 B  338  LEU LYS PRO TYR LYS LEU VAL SER ARG GLU PHE HIS PRO          
SEQRES   7 B  338  GLU ASP THR VAL ILE ASP LEU GLY ASP VAL LYS ILE GLY          
SEQRES   8 B  338  ASN GLY TYR PHE THR ILE ILE ALA GLY PRO CYS SER VAL          
SEQRES   9 B  338  GLU GLY ARG GLU MET LEU MET GLU THR ALA HIS PHE LEU          
SEQRES  10 B  338  SER GLU LEU GLY VAL LYS VAL LEU ARG GLY GLY ALA TYR          
SEQRES  11 B  338  LYS PRO ARG THR SER PRO TYR SER PHE GLN GLY LEU GLY          
SEQRES  12 B  338  GLU LYS GLY LEU GLU TYR LEU ARG GLU ALA ALA ASP LYS          
SEQRES  13 B  338  TYR GLY MET TYR VAL VAL THR GLU ALA LEU GLY GLU ASP          
SEQRES  14 B  338  ASP LEU PRO LYS VAL ALA GLU TYR ALA ASP ILE ILE GLN          
SEQRES  15 B  338  ILE GLY ALA ARG ASN ALA GLN ASN PHE ARG LEU LEU SER          
SEQRES  16 B  338  LYS ALA GLY SER TYR ASN LYS PRO VAL LEU LEU LYS ARG          
SEQRES  17 B  338  GLY PHE MET ASN THR ILE GLU GLU PHE LEU LEU SER ALA          
SEQRES  18 B  338  GLU TYR ILE ALA ASN SER GLY ASN THR LYS ILE ILE LEU          
SEQRES  19 B  338  CYS GLU ARG GLY ILE ARG THR PHE GLU LYS ALA THR ARG          
SEQRES  20 B  338  ASN THR LEU ASP ILE SER ALA VAL PRO ILE ILE ARG LYS          
SEQRES  21 B  338  GLU SER HIS LEU PRO ILE LEU VAL ASP PRO SER HIS SER          
SEQRES  22 B  338  GLY GLY ARG ARG ASP LEU VAL ILE PRO LEU SER ARG ALA          
SEQRES  23 B  338  ALA ILE ALA VAL GLY ALA HIS GLY ILE ILE VAL GLU VAL          
SEQRES  24 B  338  HIS PRO GLU PRO GLU LYS ALA LEU SER ASP GLY LYS GLN          
SEQRES  25 B  338  SER LEU ASP PHE GLU LEU PHE LYS GLU LEU VAL GLN GLU          
SEQRES  26 B  338  MET LYS LYS LEU ALA ASP ALA LEU GLY VAL LYS VAL ASN          
SEQRES   1 C  338  MET ILE VAL VAL LEU LYS PRO GLY SER THR GLU GLU ASP          
SEQRES   2 C  338  ILE ARG LYS VAL VAL LYS LEU ALA GLU SER TYR ASN LEU          
SEQRES   3 C  338  LYS CYS HIS ILE SER LYS GLY GLN GLU ARG THR VAL ILE          
SEQRES   4 C  338  GLY ILE ILE GLY ASP ASP ARG TYR VAL VAL ALA ASP LYS          
SEQRES   5 C  338  PHE GLU SER LEU ASP CYS VAL GLU SER VAL VAL ARG VAL          
SEQRES   6 C  338  LEU LYS PRO TYR LYS LEU VAL SER ARG GLU PHE HIS PRO          
SEQRES   7 C  338  GLU ASP THR VAL ILE ASP LEU GLY ASP VAL LYS ILE GLY          
SEQRES   8 C  338  ASN GLY TYR PHE THR ILE ILE ALA GLY PRO CYS SER VAL          
SEQRES   9 C  338  GLU GLY ARG GLU MET LEU MET GLU THR ALA HIS PHE LEU          
SEQRES  10 C  338  SER GLU LEU GLY VAL LYS VAL LEU ARG GLY GLY ALA TYR          
SEQRES  11 C  338  LYS PRO ARG THR SER PRO TYR SER PHE GLN GLY LEU GLY          
SEQRES  12 C  338  GLU LYS GLY LEU GLU TYR LEU ARG GLU ALA ALA ASP LYS          
SEQRES  13 C  338  TYR GLY MET TYR VAL VAL THR GLU ALA LEU GLY GLU ASP          
SEQRES  14 C  338  ASP LEU PRO LYS VAL ALA GLU TYR ALA ASP ILE ILE GLN          
SEQRES  15 C  338  ILE GLY ALA ARG ASN ALA GLN ASN PHE ARG LEU LEU SER          
SEQRES  16 C  338  LYS ALA GLY SER TYR ASN LYS PRO VAL LEU LEU LYS ARG          
SEQRES  17 C  338  GLY PHE MET ASN THR ILE GLU GLU PHE LEU LEU SER ALA          
SEQRES  18 C  338  GLU TYR ILE ALA ASN SER GLY ASN THR LYS ILE ILE LEU          
SEQRES  19 C  338  CYS GLU ARG GLY ILE ARG THR PHE GLU LYS ALA THR ARG          
SEQRES  20 C  338  ASN THR LEU ASP ILE SER ALA VAL PRO ILE ILE ARG LYS          
SEQRES  21 C  338  GLU SER HIS LEU PRO ILE LEU VAL ASP PRO SER HIS SER          
SEQRES  22 C  338  GLY GLY ARG ARG ASP LEU VAL ILE PRO LEU SER ARG ALA          
SEQRES  23 C  338  ALA ILE ALA VAL GLY ALA HIS GLY ILE ILE VAL GLU VAL          
SEQRES  24 C  338  HIS PRO GLU PRO GLU LYS ALA LEU SER ASP GLY LYS GLN          
SEQRES  25 C  338  SER LEU ASP PHE GLU LEU PHE LYS GLU LEU VAL GLN GLU          
SEQRES  26 C  338  MET LYS LYS LEU ALA ASP ALA LEU GLY VAL LYS VAL ASN          
SEQRES   1 D  338  MET ILE VAL VAL LEU LYS PRO GLY SER THR GLU GLU ASP          
SEQRES   2 D  338  ILE ARG LYS VAL VAL LYS LEU ALA GLU SER TYR ASN LEU          
SEQRES   3 D  338  LYS CYS HIS ILE SER LYS GLY GLN GLU ARG THR VAL ILE          
SEQRES   4 D  338  GLY ILE ILE GLY ASP ASP ARG TYR VAL VAL ALA ASP LYS          
SEQRES   5 D  338  PHE GLU SER LEU ASP CYS VAL GLU SER VAL VAL ARG VAL          
SEQRES   6 D  338  LEU LYS PRO TYR LYS LEU VAL SER ARG GLU PHE HIS PRO          
SEQRES   7 D  338  GLU ASP THR VAL ILE ASP LEU GLY ASP VAL LYS ILE GLY          
SEQRES   8 D  338  ASN GLY TYR PHE THR ILE ILE ALA GLY PRO CYS SER VAL          
SEQRES   9 D  338  GLU GLY ARG GLU MET LEU MET GLU THR ALA HIS PHE LEU          
SEQRES  10 D  338  SER GLU LEU GLY VAL LYS VAL LEU ARG GLY GLY ALA TYR          
SEQRES  11 D  338  LYS PRO ARG THR SER PRO TYR SER PHE GLN GLY LEU GLY          
SEQRES  12 D  338  GLU LYS GLY LEU GLU TYR LEU ARG GLU ALA ALA ASP LYS          
SEQRES  13 D  338  TYR GLY MET TYR VAL VAL THR GLU ALA LEU GLY GLU ASP          
SEQRES  14 D  338  ASP LEU PRO LYS VAL ALA GLU TYR ALA ASP ILE ILE GLN          
SEQRES  15 D  338  ILE GLY ALA ARG ASN ALA GLN ASN PHE ARG LEU LEU SER          
SEQRES  16 D  338  LYS ALA GLY SER TYR ASN LYS PRO VAL LEU LEU LYS ARG          
SEQRES  17 D  338  GLY PHE MET ASN THR ILE GLU GLU PHE LEU LEU SER ALA          
SEQRES  18 D  338  GLU TYR ILE ALA ASN SER GLY ASN THR LYS ILE ILE LEU          
SEQRES  19 D  338  CYS GLU ARG GLY ILE ARG THR PHE GLU LYS ALA THR ARG          
SEQRES  20 D  338  ASN THR LEU ASP ILE SER ALA VAL PRO ILE ILE ARG LYS          
SEQRES  21 D  338  GLU SER HIS LEU PRO ILE LEU VAL ASP PRO SER HIS SER          
SEQRES  22 D  338  GLY GLY ARG ARG ASP LEU VAL ILE PRO LEU SER ARG ALA          
SEQRES  23 D  338  ALA ILE ALA VAL GLY ALA HIS GLY ILE ILE VAL GLU VAL          
SEQRES  24 D  338  HIS PRO GLU PRO GLU LYS ALA LEU SER ASP GLY LYS GLN          
SEQRES  25 D  338  SER LEU ASP PHE GLU LEU PHE LYS GLU LEU VAL GLN GLU          
SEQRES  26 D  338  MET LYS LYS LEU ALA ASP ALA LEU GLY VAL LYS VAL ASN          
SEQRES   1 E  338  MET ILE VAL VAL LEU LYS PRO GLY SER THR GLU GLU ASP          
SEQRES   2 E  338  ILE ARG LYS VAL VAL LYS LEU ALA GLU SER TYR ASN LEU          
SEQRES   3 E  338  LYS CYS HIS ILE SER LYS GLY GLN GLU ARG THR VAL ILE          
SEQRES   4 E  338  GLY ILE ILE GLY ASP ASP ARG TYR VAL VAL ALA ASP LYS          
SEQRES   5 E  338  PHE GLU SER LEU ASP CYS VAL GLU SER VAL VAL ARG VAL          
SEQRES   6 E  338  LEU LYS PRO TYR LYS LEU VAL SER ARG GLU PHE HIS PRO          
SEQRES   7 E  338  GLU ASP THR VAL ILE ASP LEU GLY ASP VAL LYS ILE GLY          
SEQRES   8 E  338  ASN GLY TYR PHE THR ILE ILE ALA GLY PRO CYS SER VAL          
SEQRES   9 E  338  GLU GLY ARG GLU MET LEU MET GLU THR ALA HIS PHE LEU          
SEQRES  10 E  338  SER GLU LEU GLY VAL LYS VAL LEU ARG GLY GLY ALA TYR          
SEQRES  11 E  338  LYS PRO ARG THR SER PRO TYR SER PHE GLN GLY LEU GLY          
SEQRES  12 E  338  GLU LYS GLY LEU GLU TYR LEU ARG GLU ALA ALA ASP LYS          
SEQRES  13 E  338  TYR GLY MET TYR VAL VAL THR GLU ALA LEU GLY GLU ASP          
SEQRES  14 E  338  ASP LEU PRO LYS VAL ALA GLU TYR ALA ASP ILE ILE GLN          
SEQRES  15 E  338  ILE GLY ALA ARG ASN ALA GLN ASN PHE ARG LEU LEU SER          
SEQRES  16 E  338  LYS ALA GLY SER TYR ASN LYS PRO VAL LEU LEU LYS ARG          
SEQRES  17 E  338  GLY PHE MET ASN THR ILE GLU GLU PHE LEU LEU SER ALA          
SEQRES  18 E  338  GLU TYR ILE ALA ASN SER GLY ASN THR LYS ILE ILE LEU          
SEQRES  19 E  338  CYS GLU ARG GLY ILE ARG THR PHE GLU LYS ALA THR ARG          
SEQRES  20 E  338  ASN THR LEU ASP ILE SER ALA VAL PRO ILE ILE ARG LYS          
SEQRES  21 E  338  GLU SER HIS LEU PRO ILE LEU VAL ASP PRO SER HIS SER          
SEQRES  22 E  338  GLY GLY ARG ARG ASP LEU VAL ILE PRO LEU SER ARG ALA          
SEQRES  23 E  338  ALA ILE ALA VAL GLY ALA HIS GLY ILE ILE VAL GLU VAL          
SEQRES  24 E  338  HIS PRO GLU PRO GLU LYS ALA LEU SER ASP GLY LYS GLN          
SEQRES  25 E  338  SER LEU ASP PHE GLU LEU PHE LYS GLU LEU VAL GLN GLU          
SEQRES  26 E  338  MET LYS LYS LEU ALA ASP ALA LEU GLY VAL LYS VAL ASN          
SEQRES   1 F  338  MET ILE VAL VAL LEU LYS PRO GLY SER THR GLU GLU ASP          
SEQRES   2 F  338  ILE ARG LYS VAL VAL LYS LEU ALA GLU SER TYR ASN LEU          
SEQRES   3 F  338  LYS CYS HIS ILE SER LYS GLY GLN GLU ARG THR VAL ILE          
SEQRES   4 F  338  GLY ILE ILE GLY ASP ASP ARG TYR VAL VAL ALA ASP LYS          
SEQRES   5 F  338  PHE GLU SER LEU ASP CYS VAL GLU SER VAL VAL ARG VAL          
SEQRES   6 F  338  LEU LYS PRO TYR LYS LEU VAL SER ARG GLU PHE HIS PRO          
SEQRES   7 F  338  GLU ASP THR VAL ILE ASP LEU GLY ASP VAL LYS ILE GLY          
SEQRES   8 F  338  ASN GLY TYR PHE THR ILE ILE ALA GLY PRO CYS SER VAL          
SEQRES   9 F  338  GLU GLY ARG GLU MET LEU MET GLU THR ALA HIS PHE LEU          
SEQRES  10 F  338  SER GLU LEU GLY VAL LYS VAL LEU ARG GLY GLY ALA TYR          
SEQRES  11 F  338  LYS PRO ARG THR SER PRO TYR SER PHE GLN GLY LEU GLY          
SEQRES  12 F  338  GLU LYS GLY LEU GLU TYR LEU ARG GLU ALA ALA ASP LYS          
SEQRES  13 F  338  TYR GLY MET TYR VAL VAL THR GLU ALA LEU GLY GLU ASP          
SEQRES  14 F  338  ASP LEU PRO LYS VAL ALA GLU TYR ALA ASP ILE ILE GLN          
SEQRES  15 F  338  ILE GLY ALA ARG ASN ALA GLN ASN PHE ARG LEU LEU SER          
SEQRES  16 F  338  LYS ALA GLY SER TYR ASN LYS PRO VAL LEU LEU LYS ARG          
SEQRES  17 F  338  GLY PHE MET ASN THR ILE GLU GLU PHE LEU LEU SER ALA          
SEQRES  18 F  338  GLU TYR ILE ALA ASN SER GLY ASN THR LYS ILE ILE LEU          
SEQRES  19 F  338  CYS GLU ARG GLY ILE ARG THR PHE GLU LYS ALA THR ARG          
SEQRES  20 F  338  ASN THR LEU ASP ILE SER ALA VAL PRO ILE ILE ARG LYS          
SEQRES  21 F  338  GLU SER HIS LEU PRO ILE LEU VAL ASP PRO SER HIS SER          
SEQRES  22 F  338  GLY GLY ARG ARG ASP LEU VAL ILE PRO LEU SER ARG ALA          
SEQRES  23 F  338  ALA ILE ALA VAL GLY ALA HIS GLY ILE ILE VAL GLU VAL          
SEQRES  24 F  338  HIS PRO GLU PRO GLU LYS ALA LEU SER ASP GLY LYS GLN          
SEQRES  25 F  338  SER LEU ASP PHE GLU LEU PHE LYS GLU LEU VAL GLN GLU          
SEQRES  26 F  338  MET LYS LYS LEU ALA ASP ALA LEU GLY VAL LYS VAL ASN          
SEQRES   1 G  338  MET ILE VAL VAL LEU LYS PRO GLY SER THR GLU GLU ASP          
SEQRES   2 G  338  ILE ARG LYS VAL VAL LYS LEU ALA GLU SER TYR ASN LEU          
SEQRES   3 G  338  LYS CYS HIS ILE SER LYS GLY GLN GLU ARG THR VAL ILE          
SEQRES   4 G  338  GLY ILE ILE GLY ASP ASP ARG TYR VAL VAL ALA ASP LYS          
SEQRES   5 G  338  PHE GLU SER LEU ASP CYS VAL GLU SER VAL VAL ARG VAL          
SEQRES   6 G  338  LEU LYS PRO TYR LYS LEU VAL SER ARG GLU PHE HIS PRO          
SEQRES   7 G  338  GLU ASP THR VAL ILE ASP LEU GLY ASP VAL LYS ILE GLY          
SEQRES   8 G  338  ASN GLY TYR PHE THR ILE ILE ALA GLY PRO CYS SER VAL          
SEQRES   9 G  338  GLU GLY ARG GLU MET LEU MET GLU THR ALA HIS PHE LEU          
SEQRES  10 G  338  SER GLU LEU GLY VAL LYS VAL LEU ARG GLY GLY ALA TYR          
SEQRES  11 G  338  LYS PRO ARG THR SER PRO TYR SER PHE GLN GLY LEU GLY          
SEQRES  12 G  338  GLU LYS GLY LEU GLU TYR LEU ARG GLU ALA ALA ASP LYS          
SEQRES  13 G  338  TYR GLY MET TYR VAL VAL THR GLU ALA LEU GLY GLU ASP          
SEQRES  14 G  338  ASP LEU PRO LYS VAL ALA GLU TYR ALA ASP ILE ILE GLN          
SEQRES  15 G  338  ILE GLY ALA ARG ASN ALA GLN ASN PHE ARG LEU LEU SER          
SEQRES  16 G  338  LYS ALA GLY SER TYR ASN LYS PRO VAL LEU LEU LYS ARG          
SEQRES  17 G  338  GLY PHE MET ASN THR ILE GLU GLU PHE LEU LEU SER ALA          
SEQRES  18 G  338  GLU TYR ILE ALA ASN SER GLY ASN THR LYS ILE ILE LEU          
SEQRES  19 G  338  CYS GLU ARG GLY ILE ARG THR PHE GLU LYS ALA THR ARG          
SEQRES  20 G  338  ASN THR LEU ASP ILE SER ALA VAL PRO ILE ILE ARG LYS          
SEQRES  21 G  338  GLU SER HIS LEU PRO ILE LEU VAL ASP PRO SER HIS SER          
SEQRES  22 G  338  GLY GLY ARG ARG ASP LEU VAL ILE PRO LEU SER ARG ALA          
SEQRES  23 G  338  ALA ILE ALA VAL GLY ALA HIS GLY ILE ILE VAL GLU VAL          
SEQRES  24 G  338  HIS PRO GLU PRO GLU LYS ALA LEU SER ASP GLY LYS GLN          
SEQRES  25 G  338  SER LEU ASP PHE GLU LEU PHE LYS GLU LEU VAL GLN GLU          
SEQRES  26 G  338  MET LYS LYS LEU ALA ASP ALA LEU GLY VAL LYS VAL ASN          
SEQRES   1 H  338  MET ILE VAL VAL LEU LYS PRO GLY SER THR GLU GLU ASP          
SEQRES   2 H  338  ILE ARG LYS VAL VAL LYS LEU ALA GLU SER TYR ASN LEU          
SEQRES   3 H  338  LYS CYS HIS ILE SER LYS GLY GLN GLU ARG THR VAL ILE          
SEQRES   4 H  338  GLY ILE ILE GLY ASP ASP ARG TYR VAL VAL ALA ASP LYS          
SEQRES   5 H  338  PHE GLU SER LEU ASP CYS VAL GLU SER VAL VAL ARG VAL          
SEQRES   6 H  338  LEU LYS PRO TYR LYS LEU VAL SER ARG GLU PHE HIS PRO          
SEQRES   7 H  338  GLU ASP THR VAL ILE ASP LEU GLY ASP VAL LYS ILE GLY          
SEQRES   8 H  338  ASN GLY TYR PHE THR ILE ILE ALA GLY PRO CYS SER VAL          
SEQRES   9 H  338  GLU GLY ARG GLU MET LEU MET GLU THR ALA HIS PHE LEU          
SEQRES  10 H  338  SER GLU LEU GLY VAL LYS VAL LEU ARG GLY GLY ALA TYR          
SEQRES  11 H  338  LYS PRO ARG THR SER PRO TYR SER PHE GLN GLY LEU GLY          
SEQRES  12 H  338  GLU LYS GLY LEU GLU TYR LEU ARG GLU ALA ALA ASP LYS          
SEQRES  13 H  338  TYR GLY MET TYR VAL VAL THR GLU ALA LEU GLY GLU ASP          
SEQRES  14 H  338  ASP LEU PRO LYS VAL ALA GLU TYR ALA ASP ILE ILE GLN          
SEQRES  15 H  338  ILE GLY ALA ARG ASN ALA GLN ASN PHE ARG LEU LEU SER          
SEQRES  16 H  338  LYS ALA GLY SER TYR ASN LYS PRO VAL LEU LEU LYS ARG          
SEQRES  17 H  338  GLY PHE MET ASN THR ILE GLU GLU PHE LEU LEU SER ALA          
SEQRES  18 H  338  GLU TYR ILE ALA ASN SER GLY ASN THR LYS ILE ILE LEU          
SEQRES  19 H  338  CYS GLU ARG GLY ILE ARG THR PHE GLU LYS ALA THR ARG          
SEQRES  20 H  338  ASN THR LEU ASP ILE SER ALA VAL PRO ILE ILE ARG LYS          
SEQRES  21 H  338  GLU SER HIS LEU PRO ILE LEU VAL ASP PRO SER HIS SER          
SEQRES  22 H  338  GLY GLY ARG ARG ASP LEU VAL ILE PRO LEU SER ARG ALA          
SEQRES  23 H  338  ALA ILE ALA VAL GLY ALA HIS GLY ILE ILE VAL GLU VAL          
SEQRES  24 H  338  HIS PRO GLU PRO GLU LYS ALA LEU SER ASP GLY LYS GLN          
SEQRES  25 H  338  SER LEU ASP PHE GLU LEU PHE LYS GLU LEU VAL GLN GLU          
SEQRES  26 H  338  MET LYS LYS LEU ALA ASP ALA LEU GLY VAL LYS VAL ASN          
HET    TYR  A 339      13                                                       
HET    TYR  A 340      13                                                       
HET    AZI  A 341       3                                                       
HET    NO3  A 342       4                                                       
HET    TYR  B 339      13                                                       
HET    TYR  B 340      13                                                       
HET    AZI  B 341       3                                                       
HET     CL  B 342       1                                                       
HET    TYR  C 339      13                                                       
HET    TYR  C 340      13                                                       
HET    NO3  C 341       4                                                       
HET    TYR  D 339      13                                                       
HET    NO3  D 340       4                                                       
HET    NO3  F 339       4                                                       
HET    TYR  H 339      13                                                       
HETNAM     TYR TYROSINE                                                         
HETNAM     AZI AZIDE ION                                                        
HETNAM     NO3 NITRATE ION                                                      
HETNAM      CL CHLORIDE ION                                                     
FORMUL   9  TYR    8(C9 H11 N O3)                                               
FORMUL  11  AZI    2(N3 1-)                                                     
FORMUL  12  NO3    4(N O3 1-)                                                   
FORMUL  16   CL    CL 1-                                                        
FORMUL  24  HOH   *565(H2 O)                                                    
HELIX    1   1 THR A   10  SER A   23  1                                  14    
HELIX    2   2 ALA A   50  LEU A   56  1                                   7    
HELIX    3   3 GLY A  106  LEU A  120  1                                  15    
HELIX    4   4 GLY A  143  GLY A  158  1                                  16    
HELIX    5   5 ASP A  170  ALA A  178  1                                   9    
HELIX    6   6 GLY A  184  ALA A  188  5                                   5    
HELIX    7   7 ASN A  190  SER A  199  1                                  10    
HELIX    8   8 THR A  213  ASN A  226  1                                  14    
HELIX    9   9 SER A  253  SER A  262  1                                  10    
HELIX   10  10 ASP A  269  GLY A  275  1                                   7    
HELIX   11  11 ARG A  276  ASP A  278  5                                   3    
HELIX   12  12 LEU A  279  GLY A  291  1                                  13    
HELIX   13  13 GLU A  302  ALA A  306  5                                   5    
HELIX   14  14 ASP A  309  SER A  313  5                                   5    
HELIX   15  15 ASP A  315  GLY A  334  1                                  20    
HELIX   16  16 THR B   10  SER B   23  1                                  14    
HELIX   17  17 ALA B   50  LEU B   56  1                                   7    
HELIX   18  18 GLY B  106  LEU B  120  1                                  15    
HELIX   19  19 GLY B  143  TYR B  157  1                                  15    
HELIX   20  20 GLY B  167  ASP B  169  5                                   3    
HELIX   21  21 ASP B  170  ALA B  178  1                                   9    
HELIX   22  22 GLY B  184  ALA B  188  5                                   5    
HELIX   23  23 ASN B  190  GLY B  198  1                                   9    
HELIX   24  24 SER B  199  ASN B  201  5                                   3    
HELIX   25  25 THR B  213  SER B  227  1                                  15    
HELIX   26  26 SER B  253  SER B  262  1                                  10    
HELIX   27  27 ASP B  269  GLY B  275  1                                   7    
HELIX   28  28 ARG B  276  ASP B  278  5                                   3    
HELIX   29  29 LEU B  279  GLY B  291  1                                  13    
HELIX   30  30 GLU B  302  ALA B  306  5                                   5    
HELIX   31  31 ASP B  315  GLY B  334  1                                  20    
HELIX   32  32 THR C   10  SER C   23  1                                  14    
HELIX   33  33 ALA C   50  SER C   55  1                                   6    
HELIX   34  34 GLY C  106  LEU C  120  1                                  15    
HELIX   35  35 GLY C  143  TYR C  157  1                                  15    
HELIX   36  36 GLY C  167  ASP C  169  5                                   3    
HELIX   37  37 ASP C  170  ALA C  178  1                                   9    
HELIX   38  38 ALA C  185  GLN C  189  5                                   5    
HELIX   39  39 ASN C  190  SER C  199  1                                  10    
HELIX   40  40 THR C  213  SER C  227  1                                  15    
HELIX   41  41 SER C  253  SER C  262  1                                  10    
HELIX   42  42 ASP C  269  GLY C  275  1                                   7    
HELIX   43  43 ARG C  276  ASP C  278  5                                   3    
HELIX   44  44 LEU C  279  GLY C  291  1                                  13    
HELIX   45  45 GLU C  302  ALA C  306  5                                   5    
HELIX   46  46 ASP C  315  GLY C  334  1                                  20    
HELIX   47  47 THR D   10  TYR D   24  1                                  15    
HELIX   48  48 ALA D   50  SER D   55  1                                   6    
HELIX   49  49 GLY D  106  LEU D  120  1                                  15    
HELIX   50  50 LEU D  142  TYR D  157  1                                  16    
HELIX   51  51 ASP D  170  ALA D  178  1                                   9    
HELIX   52  52 GLY D  184  ALA D  188  5                                   5    
HELIX   53  53 ASN D  190  SER D  199  1                                  10    
HELIX   54  54 THR D  213  SER D  227  1                                  15    
HELIX   55  55 SER D  253  SER D  262  1                                  10    
HELIX   56  56 ARG D  276  ASP D  278  5                                   3    
HELIX   57  57 LEU D  279  GLY D  291  1                                  13    
HELIX   58  58 GLU D  302  ALA D  306  5                                   5    
HELIX   59  59 ASP D  315  LEU D  333  1                                  19    
HELIX   60  60 THR E   10  TYR E   24  1                                  15    
HELIX   61  61 ALA E   50  LEU E   56  1                                   7    
HELIX   62  62 GLY E  106  GLU E  119  1                                  14    
HELIX   63  63 GLY E  143  GLY E  158  1                                  16    
HELIX   64  64 ASP E  170  ALA E  178  1                                   9    
HELIX   65  65 GLY E  184  ALA E  188  5                                   5    
HELIX   66  66 ASN E  190  SER E  199  1                                  10    
HELIX   67  67 THR E  213  SER E  227  1                                  15    
HELIX   68  68 SER E  253  SER E  262  1                                  10    
HELIX   69  69 ASP E  269  GLY E  275  1                                   7    
HELIX   70  70 ARG E  276  ASP E  278  5                                   3    
HELIX   71  71 LEU E  279  GLY E  291  1                                  13    
HELIX   72  72 GLU E  302  ALA E  306  5                                   5    
HELIX   73  73 ASP E  309  SER E  313  5                                   5    
HELIX   74  74 ASP E  315  GLY E  334  1                                  20    
HELIX   75  75 THR F   10  TYR F   24  1                                  15    
HELIX   76  76 ALA F   50  SER F   55  1                                   6    
HELIX   77  77 GLY F  106  GLU F  119  1                                  14    
HELIX   78  78 GLY F  143  TYR F  157  1                                  15    
HELIX   79  79 ASP F  170  ALA F  178  1                                   9    
HELIX   80  80 GLY F  184  ALA F  188  5                                   5    
HELIX   81  81 ASN F  190  SER F  199  1                                  10    
HELIX   82  82 THR F  213  SER F  227  1                                  15    
HELIX   83  83 SER F  253  SER F  262  1                                  10    
HELIX   84  84 ASP F  269  GLY F  275  1                                   7    
HELIX   85  85 ARG F  276  ASP F  278  5                                   3    
HELIX   86  86 LEU F  279  GLY F  291  1                                  13    
HELIX   87  87 GLU F  302  ALA F  306  5                                   5    
HELIX   88  88 ASP F  309  SER F  313  5                                   5    
HELIX   89  89 ASP F  315  GLY F  334  1                                  20    
HELIX   90  90 THR G   10  SER G   23  1                                  14    
HELIX   91  91 ALA G   50  SER G   55  1                                   6    
HELIX   92  92 GLY G  106  LEU G  120  1                                  15    
HELIX   93  93 GLY G  143  GLY G  158  1                                  16    
HELIX   94  94 ASP G  170  ALA G  178  1                                   9    
HELIX   95  95 GLY G  184  ALA G  188  5                                   5    
HELIX   96  96 ASN G  190  SER G  199  1                                  10    
HELIX   97  97 THR G  213  ASN G  226  1                                  14    
HELIX   98  98 SER G  253  SER G  262  1                                  10    
HELIX   99  99 ASP G  269  GLY G  275  1                                   7    
HELIX  100 100 ARG G  276  ASP G  278  5                                   3    
HELIX  101 101 LEU G  279  GLY G  291  1                                  13    
HELIX  102 102 GLU G  302  ALA G  306  5                                   5    
HELIX  103 103 ASP G  309  SER G  313  5                                   5    
HELIX  104 104 ASP G  315  GLY G  334  1                                  20    
HELIX  105 105 THR H   10  SER H   23  1                                  14    
HELIX  106 106 ALA H   50  LEU H   56  1                                   7    
HELIX  107 107 GLY H  106  GLU H  119  1                                  14    
HELIX  108 108 GLY H  143  TYR H  157  1                                  15    
HELIX  109 109 ASP H  170  ALA H  178  1                                   9    
HELIX  110 110 ASN H  190  SER H  199  1                                  10    
HELIX  111 111 THR H  213  SER H  227  1                                  15    
HELIX  112 112 SER H  253  SER H  262  1                                  10    
HELIX  113 113 ASP H  269  GLY H  275  1                                   7    
HELIX  114 114 ARG H  276  ASP H  278  5                                   3    
HELIX  115 115 LEU H  279  GLY H  291  1                                  13    
HELIX  116 116 GLU H  302  ALA H  306  5                                   5    
HELIX  117 117 ASP H  309  SER H  313  5                                   5    
HELIX  118 118 ASP H  315  GLY H  334  1                                  20    
SHEET    1   A 4 LYS A  27  LYS A  32  0                                        
SHEET    2   A 4 THR A  37  ILE A  42 -1  O  VAL A  38   N  SER A  31           
SHEET    3   A 4 ILE A   2  LEU A   5 -1  N  VAL A   3   O  ILE A  39           
SHEET    4   A 4 VAL A  59  VAL A  63 -1  O  VAL A  63   N  ILE A   2           
SHEET    1   B 2 ILE A  83  ASP A  84  0                                        
SHEET    2   B 2 LYS A  89  ILE A  90 -1  O  ILE A  90   N  ILE A  83           
SHEET    1   C10 LYS A 336  ASN A 338  0                                        
SHEET    2   C10 TYR A  94  GLY A 100  1  N  PHE A  95   O  LYS A 336           
SHEET    3   C10 GLY A 294  GLU A 298  1  O  VAL A 297   N  ILE A  98           
SHEET    4   C10 ILE A 266  VAL A 268  1  N  VAL A 268   O  ILE A 296           
SHEET    5   C10 ILE A 232  GLU A 236  1  N  LEU A 234   O  LEU A 267           
SHEET    6   C10 VAL A 204  LYS A 207  1  N  VAL A 204   O  ILE A 233           
SHEET    7   C10 ILE A 180  ILE A 183  1  N  ILE A 181   O  LEU A 205           
SHEET    8   C10 TYR A 160  GLU A 164  1  N  VAL A 161   O  ILE A 180           
SHEET    9   C10 VAL A 124  ARG A 126  1  N  LEU A 125   O  TYR A 160           
SHEET   10   C10 TYR A  94  GLY A 100  1  N  ALA A  99   O  ARG A 126           
SHEET    1   D 4 LYS B  27  LYS B  32  0                                        
SHEET    2   D 4 THR B  37  ILE B  42 -1  O  ILE B  42   N  LYS B  27           
SHEET    3   D 4 ILE B   2  LEU B   5 -1  N  VAL B   3   O  ILE B  39           
SHEET    4   D 4 VAL B  59  VAL B  63 -1  O  VAL B  63   N  ILE B   2           
SHEET    1   E 2 ILE B  83  ASP B  84  0                                        
SHEET    2   E 2 LYS B  89  ILE B  90 -1  O  ILE B  90   N  ILE B  83           
SHEET    1   F10 LYS B 336  ASN B 338  0                                        
SHEET    2   F10 TYR B  94  GLY B 100  1  N  PHE B  95   O  ASN B 338           
SHEET    3   F10 GLY B 294  GLU B 298  1  O  ILE B 295   N  ILE B  98           
SHEET    4   F10 ILE B 266  VAL B 268  1  N  VAL B 268   O  GLY B 294           
SHEET    5   F10 ILE B 232  GLU B 236  1  N  LEU B 234   O  LEU B 267           
SHEET    6   F10 VAL B 204  LYS B 207  1  N  LEU B 206   O  ILE B 233           
SHEET    7   F10 ILE B 180  ILE B 183  1  N  ILE B 183   O  LEU B 205           
SHEET    8   F10 TYR B 160  GLU B 164  1  N  THR B 163   O  GLN B 182           
SHEET    9   F10 VAL B 124  ARG B 126  1  N  LEU B 125   O  TYR B 160           
SHEET   10   F10 TYR B  94  GLY B 100  1  N  ALA B  99   O  VAL B 124           
SHEET    1   G 4 LYS C  27  LYS C  32  0                                        
SHEET    2   G 4 THR C  37  ILE C  42 -1  O  ILE C  42   N  LYS C  27           
SHEET    3   G 4 ILE C   2  LEU C   5 -1  N  VAL C   3   O  ILE C  39           
SHEET    4   G 4 VAL C  59  VAL C  63 -1  O  VAL C  63   N  ILE C   2           
SHEET    1   H 2 ILE C  83  ASP C  84  0                                        
SHEET    2   H 2 LYS C  89  ILE C  90 -1  O  ILE C  90   N  ILE C  83           
SHEET    1   I10 LYS C 336  ASN C 338  0                                        
SHEET    2   I10 TYR C  94  GLY C 100  1  N  ILE C  97   O  ASN C 338           
SHEET    3   I10 GLY C 294  GLU C 298  1  O  VAL C 297   N  ILE C  98           
SHEET    4   I10 ILE C 266  VAL C 268  1  N  VAL C 268   O  ILE C 296           
SHEET    5   I10 ILE C 232  GLU C 236  1  N  LEU C 234   O  LEU C 267           
SHEET    6   I10 VAL C 204  LYS C 207  1  N  VAL C 204   O  ILE C 233           
SHEET    7   I10 ILE C 180  ILE C 183  1  N  ILE C 183   O  LEU C 205           
SHEET    8   I10 TYR C 160  ALA C 165  1  N  THR C 163   O  GLN C 182           
SHEET    9   I10 VAL C 124  ARG C 126  1  N  LEU C 125   O  TYR C 160           
SHEET   10   I10 TYR C  94  GLY C 100  1  N  ALA C  99   O  ARG C 126           
SHEET    1   J 4 LYS D  27  LYS D  32  0                                        
SHEET    2   J 4 THR D  37  ILE D  42 -1  O  VAL D  38   N  SER D  31           
SHEET    3   J 4 ILE D   2  LEU D   5 -1  N  VAL D   3   O  ILE D  39           
SHEET    4   J 4 VAL D  59  VAL D  63 -1  O  VAL D  63   N  ILE D   2           
SHEET    1   K 2 ILE D  83  ASP D  84  0                                        
SHEET    2   K 2 LYS D  89  ILE D  90 -1  O  ILE D  90   N  ILE D  83           
SHEET    1   L10 LYS D 336  ASN D 338  0                                        
SHEET    2   L10 TYR D  94  GLY D 100  1  N  PHE D  95   O  ASN D 338           
SHEET    3   L10 GLY D 294  GLU D 298  1  O  VAL D 297   N  ILE D  98           
SHEET    4   L10 ILE D 266  VAL D 268  1  N  VAL D 268   O  GLY D 294           
SHEET    5   L10 ILE D 232  GLU D 236  1  N  LEU D 234   O  LEU D 267           
SHEET    6   L10 VAL D 204  LYS D 207  1  N  LEU D 206   O  ILE D 233           
SHEET    7   L10 ILE D 180  ILE D 183  1  N  ILE D 183   O  LEU D 205           
SHEET    8   L10 TYR D 160  GLU D 164  1  O  VAL D 161   N  ILE D 180           
SHEET    9   L10 VAL D 124  ARG D 126  1  N  LEU D 125   O  TYR D 160           
SHEET   10   L10 TYR D  94  GLY D 100  1  N  ALA D  99   O  ARG D 126           
SHEET    1   M 4 LYS E  27  LYS E  32  0                                        
SHEET    2   M 4 THR E  37  ILE E  42 -1  O  ILE E  42   N  LYS E  27           
SHEET    3   M 4 ILE E   2  LEU E   5 -1  N  VAL E   3   O  ILE E  39           
SHEET    4   M 4 VAL E  59  VAL E  63 -1  O  GLU E  60   N  VAL E   4           
SHEET    1   N 2 ILE E  83  ASP E  84  0                                        
SHEET    2   N 2 LYS E  89  ILE E  90 -1  O  ILE E  90   N  ILE E  83           
SHEET    1   O10 LYS E 336  ASN E 338  0                                        
SHEET    2   O10 TYR E  94  GLY E 100  1  N  PHE E  95   O  LYS E 336           
SHEET    3   O10 GLY E 294  GLU E 298  1  O  VAL E 297   N  ILE E  98           
SHEET    4   O10 ILE E 266  VAL E 268  1  N  VAL E 268   O  GLY E 294           
SHEET    5   O10 ILE E 232  GLU E 236  1  N  LEU E 234   O  LEU E 267           
SHEET    6   O10 VAL E 204  LYS E 207  1  N  LEU E 206   O  ILE E 233           
SHEET    7   O10 ILE E 180  ILE E 183  1  N  ILE E 181   O  LEU E 205           
SHEET    8   O10 TYR E 160  GLU E 164  1  N  VAL E 161   O  ILE E 180           
SHEET    9   O10 VAL E 124  ARG E 126  1  N  LEU E 125   O  VAL E 162           
SHEET   10   O10 TYR E  94  GLY E 100  1  N  ALA E  99   O  VAL E 124           
SHEET    1   P 4 LYS F  27  LYS F  32  0                                        
SHEET    2   P 4 THR F  37  ILE F  42 -1  O  VAL F  38   N  SER F  31           
SHEET    3   P 4 ILE F   2  LEU F   5 -1  N  VAL F   3   O  ILE F  39           
SHEET    4   P 4 VAL F  59  VAL F  63 -1  O  VAL F  63   N  ILE F   2           
SHEET    1   Q 2 ILE F  83  ASP F  84  0                                        
SHEET    2   Q 2 LYS F  89  ILE F  90 -1  O  ILE F  90   N  ILE F  83           
SHEET    1   R10 LYS F 336  ASN F 338  0                                        
SHEET    2   R10 TYR F  94  GLY F 100  1  N  PHE F  95   O  LYS F 336           
SHEET    3   R10 GLY F 294  GLU F 298  1  O  VAL F 297   N  ILE F  98           
SHEET    4   R10 ILE F 266  VAL F 268  1  N  VAL F 268   O  GLY F 294           
SHEET    5   R10 ILE F 232  GLU F 236  1  N  LEU F 234   O  LEU F 267           
SHEET    6   R10 VAL F 204  LYS F 207  1  N  VAL F 204   O  ILE F 233           
SHEET    7   R10 ILE F 180  ILE F 183  1  N  ILE F 183   O  LEU F 205           
SHEET    8   R10 TYR F 160  GLU F 164  1  N  THR F 163   O  GLN F 182           
SHEET    9   R10 VAL F 124  ARG F 126  1  N  LEU F 125   O  TYR F 160           
SHEET   10   R10 TYR F  94  GLY F 100  1  N  ALA F  99   O  ARG F 126           
SHEET    1   S 4 LYS G  27  LYS G  32  0                                        
SHEET    2   S 4 THR G  37  ILE G  42 -1  O  VAL G  38   N  SER G  31           
SHEET    3   S 4 ILE G   2  LEU G   5 -1  N  VAL G   3   O  ILE G  39           
SHEET    4   S 4 VAL G  59  VAL G  63 -1  O  GLU G  60   N  VAL G   4           
SHEET    1   T 2 ILE G  83  ASP G  84  0                                        
SHEET    2   T 2 LYS G  89  ILE G  90 -1  O  ILE G  90   N  ILE G  83           
SHEET    1   U10 LYS G 336  ASN G 338  0                                        
SHEET    2   U10 TYR G  94  GLY G 100  1  N  ILE G  97   O  ASN G 338           
SHEET    3   U10 GLY G 294  GLU G 298  1  O  VAL G 297   N  ILE G  98           
SHEET    4   U10 ILE G 266  VAL G 268  1  N  VAL G 268   O  ILE G 296           
SHEET    5   U10 ILE G 232  GLU G 236  1  N  LEU G 234   O  LEU G 267           
SHEET    6   U10 VAL G 204  LYS G 207  1  N  VAL G 204   O  ILE G 233           
SHEET    7   U10 ILE G 180  ILE G 183  1  N  ILE G 183   O  LEU G 205           
SHEET    8   U10 TYR G 160  GLU G 164  1  N  THR G 163   O  GLN G 182           
SHEET    9   U10 VAL G 124  ARG G 126  1  N  LEU G 125   O  TYR G 160           
SHEET   10   U10 TYR G  94  GLY G 100  1  N  ALA G  99   O  ARG G 126           
SHEET    1   V 4 LYS H  27  LYS H  32  0                                        
SHEET    2   V 4 THR H  37  ILE H  42 -1  O  VAL H  38   N  SER H  31           
SHEET    3   V 4 ILE H   2  LEU H   5 -1  N  VAL H   3   O  ILE H  39           
SHEET    4   V 4 VAL H  59  VAL H  63 -1  O  VAL H  63   N  ILE H   2           
SHEET    1   W 2 ILE H  83  ASP H  84  0                                        
SHEET    2   W 2 LYS H  89  ILE H  90 -1  O  ILE H  90   N  ILE H  83           
SHEET    1   X10 LYS H 336  ASN H 338  0                                        
SHEET    2   X10 TYR H  94  GLY H 100  1  N  PHE H  95   O  LYS H 336           
SHEET    3   X10 GLY H 294  GLU H 298  1  O  VAL H 297   N  ILE H  98           
SHEET    4   X10 ILE H 266  VAL H 268  1  N  VAL H 268   O  ILE H 296           
SHEET    5   X10 ILE H 232  GLU H 236  1  N  LEU H 234   O  LEU H 267           
SHEET    6   X10 VAL H 204  LYS H 207  1  N  VAL H 204   O  ILE H 233           
SHEET    7   X10 ILE H 180  ILE H 183  1  N  ILE H 183   O  LEU H 205           
SHEET    8   X10 TYR H 160  GLU H 164  1  N  VAL H 161   O  ILE H 180           
SHEET    9   X10 VAL H 124  ARG H 126  1  N  LEU H 125   O  TYR H 160           
SHEET   10   X10 TYR H  94  GLY H 100  1  N  ALA H  99   O  ARG H 126           
CISPEP   1 ASN A   92    GLY A   93          0        -2.58                     
CISPEP   2 ASN F   92    GLY F   93          0        -2.05                     
SITE     1 AC1 12 SER A  31  GLY A  33  GLN A  34  GLU A  35                    
SITE     2 AC1 12 ARG A  36  VAL A  38  MET F   1  ILE F   2                    
SITE     3 AC1 12 GLY F  40  ILE F  41  ILE F  42  GLY F  43                    
SITE     1 AC2 15 MET A   1  ILE A   2  GLY A  40  ILE A  41                    
SITE     2 AC2 15 ILE A  42  GLY A  43  ASP A  45  VAL A  65                    
SITE     3 AC2 15 HOH A 356  SER F  31  GLY F  33  GLN F  34                    
SITE     4 AC2 15 GLU F  35  ARG F  36  VAL F  38                               
SITE     1 AC3  2 ARG A 285  GLU A 321                                          
SITE     1 AC4  5 PHE A 210  MET A 211  PHE F 242  PHE G 210                    
SITE     2 AC4  5 MET G 211                                                     
SITE     1 AC5 13 MET B   1  ILE B   2  GLY B  40  ILE B  41                    
SITE     2 AC5 13 ILE B  42  GLY B  43  ASP B  45  SER G  31                    
SITE     3 AC5 13 GLY G  33  GLN G  34  GLU G  35  ARG G  36                    
SITE     4 AC5 13 VAL G  38                                                     
SITE     1 AC6 12 SER B  31  GLY B  33  GLN B  34  GLU B  35                    
SITE     2 AC6 12 ARG B  36  MET G   1  ILE G   2  GLY G  40                    
SITE     3 AC6 12 ILE G  41  ILE G  42  GLY G  43  ASP G  45                    
SITE     1 AC7  1 PHE B  76                                                     
SITE     1 AC8  2 LYS B 207  ARG B 237                                          
SITE     1 AC9 14 MET C   1  ILE C   2  GLY C  40  ILE C  41                    
SITE     2 AC9 14 ILE C  42  GLY C  43  ASP C  45  VAL C  65                    
SITE     3 AC9 14 SER E  31  GLY E  33  GLN E  34  GLU E  35                    
SITE     4 AC9 14 ARG E  36  VAL E  38                                          
SITE     1 BC1 11 SER C  31  GLY C  33  GLN C  34  GLU C  35                    
SITE     2 BC1 11 ARG C  36  VAL C  38  MET E   1  ILE E  41                    
SITE     3 BC1 11 ILE E  42  GLY E  43  LEU E  66                               
SITE     1 BC2  6 PHE C 210  MET C 211  PHE D 242  PHE E 242                    
SITE     2 BC2  6 PHE H 210  MET H 211                                          
SITE     1 BC3 14 SER D  31  GLY D  33  GLN D  34  GLU D  35                    
SITE     2 BC3 14 ARG D  36  VAL D  38  MET H   1  ILE H   2                    
SITE     3 BC3 14 GLY H  40  ILE H  41  ILE H  42  GLY H  43                    
SITE     4 BC3 14 ASP H  45  LEU H  66                                          
SITE     1 BC4  6 PHE C 242  PHE D 210  MET D 211  ARG D 240                    
SITE     2 BC4  6 PHE E 210  MET E 211                                          
SITE     1 BC5  7 PHE A 242  PHE B 210  MET B 211  PHE F 210                    
SITE     2 BC5  7 MET F 211  ARG F 240  PHE G 242                               
SITE     1 BC6 14 MET D   1  ILE D   2  GLY D  40  ILE D  41                    
SITE     2 BC6 14 ILE D  42  GLY D  43  ASP D  45  HOH D 375                    
SITE     3 BC6 14 SER H  31  GLY H  33  GLN H  34  GLU H  35                    
SITE     4 BC6 14 ARG H  36  VAL H  38                                          
CRYST1   81.610  121.002  133.379  90.00  92.12  90.00 P 1 21 1     16          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.012253  0.000000  0.000454        0.00000                         
SCALE2      0.000000  0.008264  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.007503        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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