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Database: PDB
Entry: 3ZLR
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HEADER    APOPTOSIS                               04-FEB-13   3ZLR              
TITLE     CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH INHIBITOR (WEHI-539)      
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: BCL-2-LIKE PROTEIN 1;                                      
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 FRAGMENT: RESIDUES 1-26,83-209;                                      
COMPND   5 SYNONYM: BCL2-L-1, APOPTOSIS REGULATOR BCL-X, BCL-XL;                
COMPND   6 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 511693;                                     
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21;                                      
SOURCE   8 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE   9 EXPRESSION_SYSTEM_VECTOR: PGEX-6P3                                   
KEYWDS    APOPTOSIS, INHIBITOR                                                  
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    P.E.CZABOTAR,G.L.LESSENE,B.J.SMITH,P.M.COLMAN                         
REVDAT   4   13-JUN-18 3ZLR    1       TITLE  JRNL                              
REVDAT   3   05-JUN-13 3ZLR    1       JRNL                                     
REVDAT   2   08-MAY-13 3ZLR    1       JRNL                                     
REVDAT   1   24-APR-13 3ZLR    0                                                
JRNL        AUTH   G.L.LESSENE,P.E.CZABOTAR,B.E.SLEEBS,K.ZOBEL,K.L.LOWES,       
JRNL        AUTH 2 J.M.ADAMS,J.B.BAELL,P.M.COLMAN,K.DESHAYES,W.J.FAIRBROTHER,   
JRNL        AUTH 3 J.A.FLYGARE,P.GIBBONS,W.J.A.KERSTEN,S.KULASEGARAM,R.M.MOSS,  
JRNL        AUTH 4 J.P.PARISOT,B.J.SMITH,I.P.STREET,H.YANG,D.C.S.HUANG,         
JRNL        AUTH 5 K.G.WATSON                                                   
JRNL        TITL   STRUCTURE-GUIDED DESIGN OF A SELECTIVE BCL-XL INHIBITOR      
JRNL        REF    NAT.CHEM.BIOL.                V.   9   390 2013              
JRNL        REFN                   ISSN 1552-4450                               
JRNL        PMID   23603658                                                     
JRNL        DOI    10.1038/NCHEMBIO.1246                                        
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.03 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.8.1_1168)                   
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.03                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 44.00                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 2.020                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 97.2                           
REMARK   3   NUMBER OF REFLECTIONS             : 22506                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.161                           
REMARK   3   R VALUE            (WORKING SET) : 0.158                           
REMARK   3   FREE R VALUE                     : 0.208                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.100                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 1152                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 44.0118 -  4.0516    1.00     2986   144  0.1561 0.1838        
REMARK   3     2  4.0516 -  3.2162    0.99     2784   146  0.1382 0.1770        
REMARK   3     3  3.2162 -  2.8097    0.99     2721   127  0.1619 0.2243        
REMARK   3     4  2.8097 -  2.5529    0.98     2642   164  0.1609 0.2099        
REMARK   3     5  2.5529 -  2.3699    0.98     2672   132  0.1602 0.2409        
REMARK   3     6  2.3699 -  2.2302    0.97     2606   160  0.1616 0.2360        
REMARK   3     7  2.2302 -  2.1185    0.97     2590   147  0.1686 0.2288        
REMARK   3     8  2.1185 -  2.0263    0.88     2353   132  0.2021 0.2334        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.10                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.190            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 16.540           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.007           2501                                  
REMARK   3   ANGLE     :  1.196           3390                                  
REMARK   3   CHIRALITY :  0.065            338                                  
REMARK   3   PLANARITY :  0.005            433                                  
REMARK   3   DIHEDRAL  : 12.914            876                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 14                                         
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: CHAIN A AND (RESSEQ -4:20)                             
REMARK   3    ORIGIN FOR THE GROUP (A):  -2.0427  12.5416 -35.5281              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1381 T22:   0.0659                                     
REMARK   3      T33:   0.1227 T12:  -0.0107                                     
REMARK   3      T13:  -0.0162 T23:   0.0367                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.1823 L22:   3.3944                                     
REMARK   3      L33:   7.3685 L12:  -0.7105                                     
REMARK   3      L13:  -1.2035 L23:   3.6516                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1446 S12:   0.0288 S13:  -0.0164                       
REMARK   3      S21:  -0.0671 S22:   0.0028 S23:  -0.0122                       
REMARK   3      S31:   0.0385 S32:  -0.2805 S33:   0.1398                       
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: CHAIN A AND (RESSEQ 21:100)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -4.9083  -2.0636 -44.1158              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1607 T22:   0.0985                                     
REMARK   3      T33:   0.0918 T12:   0.0027                                     
REMARK   3      T13:   0.0274 T23:   0.0133                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.6671 L22:   2.0868                                     
REMARK   3      L33:   1.6528 L12:   1.2796                                     
REMARK   3      L13:   1.9152 L23:   1.3946                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0599 S12:   0.0469 S13:  -0.0646                       
REMARK   3      S21:  -0.0013 S22:   0.0748 S23:  -0.1630                       
REMARK   3      S31:  -0.0876 S32:  -0.0689 S33:  -0.1163                       
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: CHAIN A AND (RESSEQ 101:112)                           
REMARK   3    ORIGIN FOR THE GROUP (A): -24.2542  -9.6849 -47.5117              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2172 T22:   0.2311                                     
REMARK   3      T33:   0.2111 T12:  -0.0625                                     
REMARK   3      T13:  -0.0863 T23:  -0.0270                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.0197 L22:   5.2104                                     
REMARK   3      L33:   7.7056 L12:  -3.5477                                     
REMARK   3      L13:  -5.9058 L23:   3.3403                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3010 S12:   0.1835 S13:   0.3277                       
REMARK   3      S21:  -0.6092 S22:   0.1365 S23:   0.5772                       
REMARK   3      S31:   0.2752 S32:  -0.6193 S33:   0.1522                       
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: CHAIN A AND (RESSEQ 113:131)                           
REMARK   3    ORIGIN FOR THE GROUP (A): -26.1638 -10.7067 -34.1325              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1039 T22:   0.1719                                     
REMARK   3      T33:   0.2458 T12:  -0.0232                                     
REMARK   3      T13:   0.0020 T23:  -0.0268                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.8376 L22:   5.9071                                     
REMARK   3      L33:   3.4662 L12:  -4.4727                                     
REMARK   3      L13:  -1.9185 L23:   2.0781                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2033 S12:  -0.0672 S13:  -0.5969                       
REMARK   3      S21:  -0.0720 S22:   0.1114 S23:   0.7556                       
REMARK   3      S31:   0.2144 S32:  -0.4519 S33:   0.0702                       
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: CHAIN A AND (RESSEQ 132:136)                           
REMARK   3    ORIGIN FOR THE GROUP (A): -16.3724 -20.6532 -41.8338              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2507 T22:   0.1107                                     
REMARK   3      T33:   0.2241 T12:  -0.0160                                     
REMARK   3      T13:  -0.0596 T23:   0.0264                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.3717 L22:   2.5132                                     
REMARK   3      L33:   4.5474 L12:   1.4539                                     
REMARK   3      L13:  -5.4926 L23:  -0.3985                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3519 S12:   0.3124 S13:  -0.0635                       
REMARK   3      S21:  -0.5579 S22:   0.5118 S23:   0.6653                       
REMARK   3      S31:   0.4923 S32:  -0.0440 S33:  -0.0847                       
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: CHAIN A AND (RESSEQ 137:156)                           
REMARK   3    ORIGIN FOR THE GROUP (A): -18.7071  -5.2577 -40.8922              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1230 T22:   0.1083                                     
REMARK   3      T33:   0.0498 T12:   0.0033                                     
REMARK   3      T13:  -0.0305 T23:   0.0005                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3760 L22:   4.8589                                     
REMARK   3      L33:   1.5002 L12:  -1.2723                                     
REMARK   3      L13:  -0.3111 L23:   0.6670                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1228 S12:   0.0515 S13:  -0.1362                       
REMARK   3      S21:   0.0293 S22:   0.0045 S23:   0.5090                       
REMARK   3      S31:  -0.0282 S32:  -0.1028 S33:   0.1164                       
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: CHAIN A AND (RESSEQ 157:177)                           
REMARK   3    ORIGIN FOR THE GROUP (A): -21.4636  -3.3899 -31.8128              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0813 T22:   0.1118                                     
REMARK   3      T33:   0.0682 T12:  -0.0231                                     
REMARK   3      T13:   0.0200 T23:  -0.0099                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.8531 L22:   5.7066                                     
REMARK   3      L33:   2.9064 L12:  -2.0587                                     
REMARK   3      L13:  -0.0743 L23:  -0.0300                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0003 S12:   0.0109 S13:  -0.1920                       
REMARK   3      S21:   0.1618 S22:   0.0300 S23:   0.3838                       
REMARK   3      S31:   0.0350 S32:  -0.0873 S33:  -0.0457                       
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    SELECTION: CHAIN A AND (RESSEQ 178:186)                           
REMARK   3    ORIGIN FOR THE GROUP (A):  -6.0628 -17.3019 -33.7187              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1463 T22:   0.1308                                     
REMARK   3      T33:   0.2058 T12:  -0.0020                                     
REMARK   3      T13:  -0.0030 T23:   0.0278                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.5574 L22:   5.8144                                     
REMARK   3      L33:   4.2718 L12:  -4.6271                                     
REMARK   3      L13:  -1.2709 L23:  -1.0351                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0722 S12:  -0.6844 S13:   0.5227                       
REMARK   3      S21:   0.2257 S22:  -0.1292 S23:  -0.7773                       
REMARK   3      S31:   0.2615 S32:   0.2885 S33:  -0.0097                       
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    SELECTION: CHAIN A AND (RESSEQ 187:197)                           
REMARK   3    ORIGIN FOR THE GROUP (A):  -1.4180 -10.2131 -42.6974              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1812 T22:   0.0705                                     
REMARK   3      T33:   0.2256 T12:   0.0021                                     
REMARK   3      T13:   0.0472 T23:  -0.0175                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.5875 L22:   7.0267                                     
REMARK   3      L33:   7.4137 L12:  -0.6451                                     
REMARK   3      L13:   2.6931 L23:   1.6375                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1310 S12:   0.3275 S13:  -0.2458                       
REMARK   3      S21:  -0.1995 S22:   0.2199 S23:  -1.0033                       
REMARK   3      S31:  -0.1888 S32:   0.6570 S33:   0.0583                       
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    SELECTION: CHAIN B AND (RESSEQ 4:100)                             
REMARK   3    ORIGIN FOR THE GROUP (A):  -9.5897   8.8868 -41.4912              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1378 T22:   0.0810                                     
REMARK   3      T33:   0.0700 T12:   0.0015                                     
REMARK   3      T13:   0.0054 T23:  -0.0091                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.2006 L22:   2.0863                                     
REMARK   3      L33:   0.8734 L12:   1.5947                                     
REMARK   3      L13:  -0.5622 L23:  -0.1972                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0339 S12:  -0.0479 S13:   0.1042                       
REMARK   3      S21:   0.0891 S22:  -0.1109 S23:   0.0563                       
REMARK   3      S31:  -0.1601 S32:   0.0572 S33:   0.0480                       
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    SELECTION: CHAIN B AND (RESSEQ 101:112)                           
REMARK   3    ORIGIN FOR THE GROUP (A):  11.6327  21.7730 -49.1089              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3423 T22:   0.2738                                     
REMARK   3      T33:   0.2636 T12:   0.0086                                     
REMARK   3      T13:   0.0937 T23:   0.0797                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.5060 L22:   6.9407                                     
REMARK   3      L33:   8.8866 L12:  -5.6387                                     
REMARK   3      L13:   6.8325 L23:  -4.5044                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.6572 S12:   0.3368 S13:   0.0787                       
REMARK   3      S21:  -1.0786 S22:  -0.0952 S23:  -0.4503                       
REMARK   3      S31:   0.2708 S32:   0.3152 S33:  -0.2646                       
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    SELECTION: CHAIN B AND (RESSEQ 113:136)                           
REMARK   3    ORIGIN FOR THE GROUP (A):  12.1551  24.3977 -37.2162              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1510 T22:   0.1714                                     
REMARK   3      T33:   0.2021 T12:  -0.0745                                     
REMARK   3      T13:   0.0374 T23:  -0.0019                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.6556 L22:   6.1885                                     
REMARK   3      L33:   3.6771 L12:  -3.6752                                     
REMARK   3      L13:   2.2313 L23:  -2.1729                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0480 S12:  -0.1229 S13:   0.2367                       
REMARK   3      S21:  -0.1888 S22:  -0.0197 S23:  -0.7889                       
REMARK   3      S31:  -0.2765 S32:   0.4026 S33:   0.1065                       
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    SELECTION: CHAIN B AND (RESSEQ 137:186)                           
REMARK   3    ORIGIN FOR THE GROUP (A):   5.2493  18.4347 -37.1700              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0786 T22:   0.0741                                     
REMARK   3      T33:   0.0747 T12:  -0.0206                                     
REMARK   3      T13:  -0.0009 T23:   0.0367                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.2510 L22:   4.2085                                     
REMARK   3      L33:   2.2254 L12:  -0.4039                                     
REMARK   3      L13:  -0.1686 L23:   0.5600                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0278 S12:  -0.0050 S13:  -0.0626                       
REMARK   3      S21:   0.1047 S22:  -0.0044 S23:  -0.1049                       
REMARK   3      S31:   0.0362 S32:   0.0723 S33:   0.0344                       
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    SELECTION: CHAIN B AND (RESSEQ 187:203)                           
REMARK   3    ORIGIN FOR THE GROUP (A): -13.4509  21.8689 -46.4194              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2611 T22:   0.2418                                     
REMARK   3      T33:   0.3191 T12:   0.0093                                     
REMARK   3      T13:  -0.0852 T23:   0.0156                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.5679 L22:   2.9443                                     
REMARK   3      L33:   2.6619 L12:  -0.1821                                     
REMARK   3      L13:   0.3516 L23:   1.9607                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0656 S12:   0.7036 S13:  -0.1143                       
REMARK   3      S21:  -0.6715 S22:  -0.2578 S23:   0.5956                       
REMARK   3      S31:  -0.6074 S32:  -0.5352 S33:   0.1030                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 3ZLR COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 04-FEB-13.                  
REMARK 100 THE DEPOSITION ID IS D_1290055719.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 25-OCT-07                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 5.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : N                                  
REMARK 200  RADIATION SOURCE               : ROTATING ANODE                     
REMARK 200  BEAMLINE                       : NULL                               
REMARK 200  X-RAY GENERATOR MODEL          : RIGAKU MICROMAX                    
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.5418                             
REMARK 200  MONOCHROMATOR                  : NI FILTER                          
REMARK 200  OPTICS                         : MEECO CAPILLARY                    
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : IMAGE PLATE                        
REMARK 200  DETECTOR MANUFACTURER          : RIGAKU RAXIS-IV                    
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : XDS                                
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 22506                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.030                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 49.680                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000                             
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 97.2                               
REMARK 200  DATA REDUNDANCY                : 86.57                              
REMARK 200  R MERGE                    (I) : 0.12000                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 21.9800                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.03                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.10                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 86.6                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 10.78                              
REMARK 200  R MERGE FOR SHELL          (I) : 0.50000                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 4.280                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: PDB ENTRY 3ZK6 CHAIN A                               
REMARK 200                                                                      
REMARK 200 REMARK: NONE                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 47.36                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.34                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 1.6 M (NH4)2 SO4, 100 MM MES PH 5.5      
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 43 2 2                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,-Y,Z+1/2                                             
REMARK 290       3555   -Y,X,Z+3/4                                              
REMARK 290       4555   Y,-X,Z+1/4                                              
REMARK 290       5555   -X,Y,-Z                                                 
REMARK 290       6555   X,-Y,-Z+1/2                                             
REMARK 290       7555   Y,X,-Z+1/4                                              
REMARK 290       8555   -Y,-X,-Z+3/4                                            
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      105.97500            
REMARK 290   SMTRY1   3  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY2   3  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000      158.96250            
REMARK 290   SMTRY1   4  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY2   4 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000       52.98750            
REMARK 290   SMTRY1   5 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   6  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000      105.97500            
REMARK 290   SMTRY1   7  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY2   7  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000       52.98750            
REMARK 290   SMTRY1   8  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY2   8 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000      158.96250            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 4940 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 14560 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -68.6 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     ASN A   198                                                      
REMARK 465     ALA A   199                                                      
REMARK 465     ALA A   200                                                      
REMARK 465     ALA A   201                                                      
REMARK 465     GLU A   202                                                      
REMARK 465     SER A   203                                                      
REMARK 465     ARG A   204                                                      
REMARK 465     LYS A   205                                                      
REMARK 465     GLY A   206                                                      
REMARK 465     GLN A   207                                                      
REMARK 465     GLU A   208                                                      
REMARK 465     ARG A   209                                                      
REMARK 465     GLY B    -4                                                      
REMARK 465     PRO B    -3                                                      
REMARK 465     LEU B    -2                                                      
REMARK 465     GLY B    -1                                                      
REMARK 465     SER B     0                                                      
REMARK 465     MET B     1                                                      
REMARK 465     SER B     2                                                      
REMARK 465     GLN B     3                                                      
REMARK 465     ARG B   204                                                      
REMARK 465     LYS B   205                                                      
REMARK 465     GLY B   206                                                      
REMARK 465     GLN B   207                                                      
REMARK 465     GLU B   208                                                      
REMARK 465     ARG B   209                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    HOH A  2086     O    HOH A  2129              2.14            
REMARK 500   O    HOH B  2071     O    HOH B  2076              2.16            
REMARK 500   OE2  GLU B     7     O    HOH B  2004              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    HIS B 113       66.38     36.87                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE X0B A 1198                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE EDO A 1199                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE EDO A 1200                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 1201                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE X0B B 1204                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 B 1205                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 B 1206                
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 3ZLN   RELATED DB: PDB                                   
REMARK 900 CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH INHIBITOR (COMPOUND 3).  
REMARK 900 RELATED ID: 3ZLO   RELATED DB: PDB                                   
REMARK 900 CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH INHIBITOR (COMPOUND 6).  
REMARK 900 RELATED ID: 3ZK6   RELATED DB: PDB                                   
REMARK 900 CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH INHIBITOR (COMPOUND 2).  
DBREF  3ZLR A    1    26  UNP    Q07817   B2CL1_HUMAN      1     26             
DBREF  3ZLR A   83   209  UNP    Q07817   B2CL1_HUMAN     83    209             
DBREF  3ZLR B    1    26  UNP    Q07817   B2CL1_HUMAN      1     26             
DBREF  3ZLR B   83   209  UNP    Q07817   B2CL1_HUMAN     83    209             
SEQADV 3ZLR GLY A   -4  UNP  Q07817              EXPRESSION TAG                 
SEQADV 3ZLR PRO A   -3  UNP  Q07817              EXPRESSION TAG                 
SEQADV 3ZLR LEU A   -2  UNP  Q07817              EXPRESSION TAG                 
SEQADV 3ZLR GLY A   -1  UNP  Q07817              EXPRESSION TAG                 
SEQADV 3ZLR SER A    0  UNP  Q07817              EXPRESSION TAG                 
SEQADV 3ZLR GLY B   -4  UNP  Q07817              EXPRESSION TAG                 
SEQADV 3ZLR PRO B   -3  UNP  Q07817              EXPRESSION TAG                 
SEQADV 3ZLR LEU B   -2  UNP  Q07817              EXPRESSION TAG                 
SEQADV 3ZLR GLY B   -1  UNP  Q07817              EXPRESSION TAG                 
SEQADV 3ZLR SER B    0  UNP  Q07817              EXPRESSION TAG                 
SEQRES   1 A  158  GLY PRO LEU GLY SER MET SER GLN SER ASN ARG GLU LEU          
SEQRES   2 A  158  VAL VAL ASP PHE LEU SER TYR LYS LEU SER GLN LYS GLY          
SEQRES   3 A  158  TYR SER TRP SER GLN MET ALA ALA VAL LYS GLN ALA LEU          
SEQRES   4 A  158  ARG GLU ALA GLY ASP GLU PHE GLU LEU ARG TYR ARG ARG          
SEQRES   5 A  158  ALA PHE SER ASP LEU THR SER GLN LEU HIS ILE THR PRO          
SEQRES   6 A  158  GLY THR ALA TYR GLN SER PHE GLU GLN VAL VAL ASN GLU          
SEQRES   7 A  158  LEU PHE ARG ASP GLY VAL ASN TRP GLY ARG ILE VAL ALA          
SEQRES   8 A  158  PHE PHE SER PHE GLY GLY ALA LEU CYS VAL GLU SER VAL          
SEQRES   9 A  158  ASP LYS GLU MET GLN VAL LEU VAL SER ARG ILE ALA ALA          
SEQRES  10 A  158  TRP MET ALA THR TYR LEU ASN ASP HIS LEU GLU PRO TRP          
SEQRES  11 A  158  ILE GLN GLU ASN GLY GLY TRP ASP THR PHE VAL GLU LEU          
SEQRES  12 A  158  TYR GLY ASN ASN ALA ALA ALA GLU SER ARG LYS GLY GLN          
SEQRES  13 A  158  GLU ARG                                                      
SEQRES   1 B  158  GLY PRO LEU GLY SER MET SER GLN SER ASN ARG GLU LEU          
SEQRES   2 B  158  VAL VAL ASP PHE LEU SER TYR LYS LEU SER GLN LYS GLY          
SEQRES   3 B  158  TYR SER TRP SER GLN MET ALA ALA VAL LYS GLN ALA LEU          
SEQRES   4 B  158  ARG GLU ALA GLY ASP GLU PHE GLU LEU ARG TYR ARG ARG          
SEQRES   5 B  158  ALA PHE SER ASP LEU THR SER GLN LEU HIS ILE THR PRO          
SEQRES   6 B  158  GLY THR ALA TYR GLN SER PHE GLU GLN VAL VAL ASN GLU          
SEQRES   7 B  158  LEU PHE ARG ASP GLY VAL ASN TRP GLY ARG ILE VAL ALA          
SEQRES   8 B  158  PHE PHE SER PHE GLY GLY ALA LEU CYS VAL GLU SER VAL          
SEQRES   9 B  158  ASP LYS GLU MET GLN VAL LEU VAL SER ARG ILE ALA ALA          
SEQRES  10 B  158  TRP MET ALA THR TYR LEU ASN ASP HIS LEU GLU PRO TRP          
SEQRES  11 B  158  ILE GLN GLU ASN GLY GLY TRP ASP THR PHE VAL GLU LEU          
SEQRES  12 B  158  TYR GLY ASN ASN ALA ALA ALA GLU SER ARG LYS GLY GLN          
SEQRES  13 B  158  GLU ARG                                                      
HET    X0B  A1198      41                                                       
HET    EDO  A1199       4                                                       
HET    EDO  A1200       4                                                       
HET    SO4  A1201       5                                                       
HET    X0B  B1204      41                                                       
HET    SO4  B1205       5                                                       
HET    SO4  B1206       5                                                       
HETNAM     X0B 5-[3-[4-(AMINOMETHYL)PHENOXY]PROPYL]-2-[(8E)-8-(1,3-             
HETNAM   2 X0B  BENZOTHIAZOL-2-YLHYDRAZINYLIDENE)-6,7-DIHYDRO-5H-               
HETNAM   3 X0B  NAPHTHALEN-2-YL]-1,3-THIAZOLE-4-CARBOXYLIC ACID                 
HETNAM     EDO 1,2-ETHANEDIOL                                                   
HETNAM     SO4 SULFATE ION                                                      
HETSYN     EDO ETHYLENE GLYCOL                                                  
FORMUL   3  X0B    2(C31 H29 N5 O3 S2)                                          
FORMUL   4  EDO    2(C2 H6 O2)                                                  
FORMUL   6  SO4    3(O4 S 2-)                                                   
FORMUL  10  HOH   *262(H2 O)                                                    
HELIX    1   1 GLY A   -1  LYS A   20  1                                  22    
HELIX    2   2 SER A   25  TYR A  101  1                                  21    
HELIX    3   3 ARG A  102  PHE A  105  5                                   4    
HELIX    4   4 ASP A  107  HIS A  113  1                                   7    
HELIX    5   5 ALA A  119  PHE A  131  1                                  13    
HELIX    6   6 ASN A  136  LYS A  157  1                                  22    
HELIX    7   7 VAL A  161  LEU A  178  1                                  18    
HELIX    8   8 LEU A  178  ASN A  185  1                                   8    
HELIX    9   9 GLY A  186  GLY A  196  1                                  11    
HELIX   10  10 SER B    4  LYS B   20  1                                  17    
HELIX   11  11 MET B   83  TYR B  101  1                                  19    
HELIX   12  12 ARG B  102  PHE B  105  5                                   4    
HELIX   13  13 ASP B  107  HIS B  113  1                                   7    
HELIX   14  14 ALA B  119  ASN B  128  1                                  10    
HELIX   15  15 ASN B  136  LYS B  157  1                                  22    
HELIX   16  16 VAL B  161  LEU B  178  1                                  18    
HELIX   17  17 LEU B  178  ASN B  185  1                                   8    
HELIX   18  18 GLY B  186  GLY B  196  1                                  11    
HELIX   19  19 ASN B  198  SER B  203  1                                   6    
SITE     1 AC1 23 PHE A  97  TYR A 101  ARG A 102  PHE A 105                    
SITE     2 AC1 23 SER A 106  ASP A 107  LEU A 108  GLU A 129                    
SITE     3 AC1 23 LEU A 130  ARG A 132  ASN A 136  GLY A 138                    
SITE     4 AC1 23 ARG A 139  SER A 145  PHE A 146  ALA A 149                    
SITE     5 AC1 23 HOH A2074  HOH A2126  HOH A2128  HOH A2160                    
SITE     6 AC1 23 HOH A2161  ALA B 199  SER B 203                               
SITE     1 AC2  4 PHE A 131  VAL A 135  TYR A 173  HIS A 177                    
SITE     1 AC3  7 TYR A  15  HOH A2073  HOH A2074  HOH A2164                    
SITE     2 AC3  7 GLN B  88  GLU B  92  HOH B2029                               
SITE     1 AC4  5 ASN A 136  TRP A 137  GLY A 138  TYR A 195                    
SITE     2 AC4  5 HOH A2165                                                     
SITE     1 AC5 19 ALA B  93  GLU B  96  ARG B 100  TYR B 101                    
SITE     2 AC5 19 ARG B 102  PHE B 105  SER B 106  ASP B 107                    
SITE     3 AC5 19 LEU B 108  GLU B 129  LEU B 130  ASN B 136                    
SITE     4 AC5 19 GLY B 138  ARG B 139  PHE B 146  TYR B 195                    
SITE     5 AC5 19 HOH B2036  HOH B2064  HOH B2094                               
SITE     1 AC6  6 ARG B 100  ASN B 136  TRP B 137  GLY B 138                    
SITE     2 AC6  6 TYR B 195  HOH B2095                                          
SITE     1 AC7  6 ASN A 175  HOH A2020  SER B   4  ASN B   5                    
SITE     2 AC7  6 ARG B   6  HOH B2096                                          
CRYST1   56.241   56.241  211.950  90.00  90.00  90.00 P 43 2 2     16          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.017781  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.017781  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.004718        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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