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Database: PDB
Entry: 4ALN
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HEADER    OXIDOREDUCTASE                          04-MAR-12   4ALN              
TITLE     CRYSTAL STRUCTURE OF S. AUREUS FABI (P32)                             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH];            
COMPND   3 CHAIN: A, B, C, D, E, F, G, H, I, J, K, L;                           
COMPND   4 SYNONYM: ENR, ENOYL-ACP REDUCTASE;                                   
COMPND   5 EC: 1.3.1.10;                                                        
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MUTATION: YES                                                        
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: STAPHYLOCOCCUS AUREUS;                          
SOURCE   3 ORGANISM_TAXID: 1280;                                                
SOURCE   4 STRAIN: N315;                                                        
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);                                 
SOURCE   8 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE   9 EXPRESSION_SYSTEM_PLASMID: PETM-11                                   
KEYWDS    OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE SUPERFAMILY,      
KEYWDS   2 FATTY ACID BIOSYNTHESIS, LIPID SYNTHESIS                             
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    J.SCHIEBEL,C.KISKER                                                   
REVDAT   2   23-MAY-12 4ALN    1       JRNL                                     
REVDAT   1   09-MAY-12 4ALN    0                                                
JRNL        AUTH   J.SCHIEBEL,A.CHANG,H.LU,M.V.BAXTER,P.J.TONGE,C.KISKER        
JRNL        TITL   STAPHYLOCOCCUS AUREUS FABI: INHIBITION, SUBSTRATE            
JRNL        TITL 2 RECOGNITION AND POTENTIAL IMPLICATIONS FOR IN VIVO           
JRNL        TITL 3 ESSENTIALITY                                                 
JRNL        REF    STRUCTURE                     V.  20   802 2012              
JRNL        REFN                   ISSN 0969-2126                               
JRNL        PMID   22579249                                                     
JRNL        DOI    10.1016/J.STR.2012.03.013                                    
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.05 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : REFMAC 5.5.0109                                      
REMARK   3   AUTHORS     : MURSHUDOV,VAGIN,DODSON                               
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : MAXIMUM LIKELIHOOD                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.05                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 44.28                          
REMARK   3   DATA CUTOFF            (SIGMA(F)) : NONE                           
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.06                          
REMARK   3   NUMBER OF REFLECTIONS             : 58556                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   CROSS-VALIDATION METHOD          : THROUGHOUT                      
REMARK   3   FREE R VALUE TEST SET SELECTION  : RANDOM                          
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.20509                         
REMARK   3   R VALUE            (WORKING SET) : 0.20292                         
REMARK   3   FREE R VALUE                     : 0.24554                         
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.0                             
REMARK   3   FREE R VALUE TEST SET COUNT      : 3064                            
REMARK   3                                                                      
REMARK   3  FIT IN THE HIGHEST RESOLUTION BIN.                                  
REMARK   3   TOTAL NUMBER OF BINS USED           : 20                           
REMARK   3   BIN RESOLUTION RANGE HIGH       (A) : 3.048                        
REMARK   3   BIN RESOLUTION RANGE LOW        (A) : 3.127                        
REMARK   3   REFLECTION IN BIN     (WORKING SET) : 4271                         
REMARK   3   BIN COMPLETENESS (WORKING+TEST) (%) : 96.67                        
REMARK   3   BIN R VALUE           (WORKING SET) : 0.266                        
REMARK   3   BIN FREE R VALUE SET COUNT          : 168                          
REMARK   3   BIN FREE R VALUE                    : 0.394                        
REMARK   3                                                                      
REMARK   3  NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.                    
REMARK   3   PROTEIN ATOMS            : 19811                                   
REMARK   3   NUCLEIC ACID ATOMS       : 0                                       
REMARK   3   HETEROGEN ATOMS          : 0                                       
REMARK   3   SOLVENT ATOMS            : 250                                     
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 67.113                         
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 18.01                                                
REMARK   3    B22 (A**2) : 18.01                                                
REMARK   3    B33 (A**2) : -36.01                                               
REMARK   3    B12 (A**2) : 0.00                                                 
REMARK   3    B13 (A**2) : 0.00                                                 
REMARK   3    B23 (A**2) : 0.00                                                 
REMARK   3                                                                      
REMARK   3  ESTIMATED OVERALL COORDINATE ERROR.                                 
REMARK   3   ESU BASED ON R VALUE                            (A): NULL          
REMARK   3   ESU BASED ON FREE R VALUE                       (A): 0.095         
REMARK   3   ESU BASED ON MAXIMUM LIKELIHOOD                 (A): 0.275         
REMARK   3   ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 32.195        
REMARK   3                                                                      
REMARK   3  CORRELATION COEFFICIENTS.                                           
REMARK   3   CORRELATION COEFFICIENT FO-FC      : 0.926                         
REMARK   3   CORRELATION COEFFICIENT FO-FC FREE : 0.900                         
REMARK   3                                                                      
REMARK   3  RMS DEVIATIONS FROM IDEAL VALUES        COUNT    RMS    WEIGHT      
REMARK   3   BOND LENGTHS REFINED ATOMS        (A): 20036 ; 0.015 ; 0.022       
REMARK   3   BOND LENGTHS OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   BOND ANGLES REFINED ATOMS   (DEGREES): 27002 ; 1.482 ; 1.969       
REMARK   3   BOND ANGLES OTHERS          (DEGREES):  NULL ;  NULL ;  NULL       
REMARK   3   TORSION ANGLES, PERIOD 1    (DEGREES):  2521 ; 5.908 ; 5.000       
REMARK   3   TORSION ANGLES, PERIOD 2    (DEGREES):   911 ;38.466 ;25.499       
REMARK   3   TORSION ANGLES, PERIOD 3    (DEGREES):  3648 ;18.079 ;15.000       
REMARK   3   TORSION ANGLES, PERIOD 4    (DEGREES):    93 ;21.015 ;15.000       
REMARK   3   CHIRAL-CENTER RESTRAINTS       (A**3):  3160 ; 0.090 ; 0.200       
REMARK   3   GENERAL PLANES REFINED ATOMS      (A): 14731 ; 0.005 ; 0.020       
REMARK   3   GENERAL PLANES OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED CONTACTS OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   NON-BONDED TORSION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) REFINED ATOMS      (A):  NULL ;  NULL ;  NULL       
REMARK   3   H-BOND (X...Y) OTHERS             (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION REFINED ATOMS (A):  NULL ;  NULL ;  NULL       
REMARK   3   POTENTIAL METAL-ION OTHERS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW REFINED ATOMS        (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY VDW OTHERS               (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND REFINED ATOMS     (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY H-BOND OTHERS            (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION REFINED ATOMS  (A):  NULL ;  NULL ;  NULL       
REMARK   3   SYMMETRY METAL-ION OTHERS         (A):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  ISOTROPIC THERMAL FACTOR RESTRAINTS.     COUNT   RMS    WEIGHT      
REMARK   3   MAIN-CHAIN BOND REFINED ATOMS  (A**2): 12646 ; 1.390 ; 1.500       
REMARK   3   MAIN-CHAIN BOND OTHER ATOMS    (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 20261 ; 2.575 ; 2.000       
REMARK   3   SIDE-CHAIN BOND REFINED ATOMS  (A**2):  7390 ; 3.767 ; 3.000       
REMARK   3   SIDE-CHAIN ANGLE REFINED ATOMS (A**2):  6741 ; 6.595 ; 4.500       
REMARK   3                                                                      
REMARK   3  ANISOTROPIC THERMAL FACTOR RESTRAINTS.   COUNT   RMS    WEIGHT      
REMARK   3   RIGID-BOND RESTRAINTS          (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; FREE ATOMS         (A**2):  NULL ;  NULL ;  NULL       
REMARK   3   SPHERICITY; BONDED ATOMS       (A**2):  NULL ;  NULL ;  NULL       
REMARK   3                                                                      
REMARK   3  NCS RESTRAINTS STATISTICS                                           
REMARK   3   NUMBER OF DIFFERENT NCS GROUPS : NULL                              
REMARK   3                                                                      
REMARK   3  TWIN DETAILS                                                        
REMARK   3   NUMBER OF TWIN DOMAINS  : 2                                        
REMARK   3      TWIN DOMAIN   : 1                                               
REMARK   3      TWIN OPERATOR : H, K, L                                         
REMARK   3      TWIN FRACTION : 0.674                                           
REMARK   3      TWIN DOMAIN   : 2                                               
REMARK   3      TWIN OPERATOR : K, H, -L                                        
REMARK   3      TWIN FRACTION : 0.326                                           
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 62                                         
REMARK   3                                                                      
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A     3        A    98                          
REMARK   3    ORIGIN FOR THE GROUP (A):  44.6385 -10.3813  18.9036              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4497 T22:   0.3527                                     
REMARK   3      T33:   0.1508 T12:   0.0737                                     
REMARK   3      T13:   0.0155 T23:  -0.0512                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.2525 L22:   2.0502                                     
REMARK   3      L33:   3.7790 L12:   0.4126                                     
REMARK   3      L13:   0.0604 L23:  -1.1126                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0925 S12:  -0.2166 S13:   0.1982                       
REMARK   3      S21:   0.1062 S22:   0.1191 S23:  -0.1632                       
REMARK   3      S31:  -0.6888 S32:  -0.1662 S33:  -0.0266                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   107        A   147                          
REMARK   3    ORIGIN FOR THE GROUP (A):  53.0018 -24.1944  18.8150              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3000 T22:   0.2720                                     
REMARK   3      T33:   0.2323 T12:  -0.0255                                     
REMARK   3      T13:  -0.0106 T23:   0.0011                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.6219 L22:  -0.1743                                     
REMARK   3      L33:   1.5475 L12:  -1.7852                                     
REMARK   3      L13:   0.2358 L23:  -0.3287                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3193 S12:  -0.0115 S13:  -0.1588                       
REMARK   3      S21:  -0.0112 S22:   0.0957 S23:  -0.1134                       
REMARK   3      S31:  -0.0476 S32:  -0.1122 S33:   0.2236                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   154        A   194                          
REMARK   3    ORIGIN FOR THE GROUP (A):  54.3301 -25.0313  10.3122              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3575 T22:   0.3094                                     
REMARK   3      T33:   0.2291 T12:  -0.0295                                     
REMARK   3      T13:  -0.0158 T23:  -0.0026                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1472 L22:   0.6396                                     
REMARK   3      L33:   1.6898 L12:  -1.0493                                     
REMARK   3      L13:   0.4642 L23:  -0.1512                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0833 S12:  -0.0129 S13:   0.1537                       
REMARK   3      S21:  -0.0233 S22:  -0.0427 S23:  -0.2067                       
REMARK   3      S31:   0.0747 S32:   0.1553 S33:  -0.0406                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   A   205        A   255                          
REMARK   3    ORIGIN FOR THE GROUP (A):  53.9559 -15.2414  -0.7984              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3753 T22:   0.3913                                     
REMARK   3      T33:   0.2276 T12:  -0.0300                                     
REMARK   3      T13:  -0.0012 T23:  -0.0747                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.3174 L22:   2.1383                                     
REMARK   3      L33:   1.4805 L12:   0.5801                                     
REMARK   3      L13:  -0.8575 L23:  -1.0619                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0674 S12:   0.0662 S13:   0.2014                       
REMARK   3      S21:  -0.1427 S22:   0.0591 S23:  -0.2283                       
REMARK   3      S31:  -0.2084 S32:   0.2001 S33:   0.0083                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B     3        B    46                          
REMARK   3    ORIGIN FOR THE GROUP (A):  77.1543 -52.2412  17.5571              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2806 T22:   0.2136                                     
REMARK   3      T33:   0.0969 T12:   0.0226                                     
REMARK   3      T13:   0.0080 T23:  -0.0223                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.0011 L22:   2.8357                                     
REMARK   3      L33:   4.0494 L12:  -0.2367                                     
REMARK   3      L13:   1.0082 L23:  -0.2259                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1175 S12:  -0.1093 S13:   0.1835                       
REMARK   3      S21:   0.2471 S22:   0.1435 S23:  -0.1270                       
REMARK   3      S31:   0.1791 S32:   0.1233 S33:  -0.2610                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B    47        B    96                          
REMARK   3    ORIGIN FOR THE GROUP (A):  79.6057 -46.7596  22.6294              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2261 T22:   0.2691                                     
REMARK   3      T33:   0.0995 T12:   0.0025                                     
REMARK   3      T13:  -0.0235 T23:  -0.0059                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.5058 L22:   2.8713                                     
REMARK   3      L33:   2.8592 L12:   1.0870                                     
REMARK   3      L13:   0.0505 L23:   1.3062                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0466 S12:   0.1217 S13:   0.2356                       
REMARK   3      S21:   0.1124 S22:  -0.0378 S23:  -0.0160                       
REMARK   3      S31:   0.2385 S32:   0.1143 S33:  -0.0088                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   109        B   146                          
REMARK   3    ORIGIN FOR THE GROUP (A):  71.0062 -35.2136  18.0649              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3066 T22:   0.3243                                     
REMARK   3      T33:   0.2373 T12:  -0.0423                                     
REMARK   3      T13:  -0.0073 T23:  -0.0202                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.4937 L22:   1.0385                                     
REMARK   3      L33:   1.4205 L12:  -1.3193                                     
REMARK   3      L13:   0.5463 L23:   0.5988                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0172 S12:  -0.0235 S13:   0.1450                       
REMARK   3      S21:  -0.0351 S22:   0.0380 S23:  -0.0543                       
REMARK   3      S31:   0.1282 S32:  -0.0890 S33:  -0.0208                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   158        B   194                          
REMARK   3    ORIGIN FOR THE GROUP (A):  68.3782 -36.8976   9.6827              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3055 T22:   0.3367                                     
REMARK   3      T33:   0.1808 T12:  -0.0234                                     
REMARK   3      T13:  -0.0033 T23:   0.0247                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.1300 L22:   0.9992                                     
REMARK   3      L33:   1.4598 L12:  -0.3887                                     
REMARK   3      L13:  -0.4190 L23:   0.0373                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0620 S12:  -0.2177 S13:  -0.0978                       
REMARK   3      S21:  -0.1996 S22:  -0.0028 S23:   0.0456                       
REMARK   3      S31:   0.1105 S32:  -0.0148 S33:   0.0648                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   B   205        B   255                          
REMARK   3    ORIGIN FOR THE GROUP (A):  63.7159 -50.0443   2.9626              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3341 T22:   0.3451                                     
REMARK   3      T33:   0.2199 T12:   0.0064                                     
REMARK   3      T13:   0.0140 T23:  -0.0039                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2607 L22:   2.3283                                     
REMARK   3      L33:   1.9573 L12:   0.6354                                     
REMARK   3      L13:   0.2801 L23:   0.0241                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1395 S12:  -0.0938 S13:   0.0732                       
REMARK   3      S21:  -0.0982 S22:  -0.0441 S23:   0.3865                       
REMARK   3      S31:   0.1979 S32:  -0.2814 S33:   0.1836                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   C     3        C    39                          
REMARK   3    ORIGIN FOR THE GROUP (A):  80.3554 -50.5678 -16.8031              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3369 T22:   0.4254                                     
REMARK   3      T33:   0.1286 T12:   0.1133                                     
REMARK   3      T13:   0.0480 T23:  -0.0506                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.1519 L22:   7.3701                                     
REMARK   3      L33:   7.4950 L12:  -0.2461                                     
REMARK   3      L13:   1.3984 L23:  -4.8236                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2969 S12:   0.1938 S13:  -0.2919                       
REMARK   3      S21:   0.1651 S22:   0.0034 S23:  -0.4075                       
REMARK   3      S31:   0.2605 S32:   0.6972 S33:  -0.3003                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   C    40        C    94                          
REMARK   3    ORIGIN FOR THE GROUP (A):  75.5173 -51.9865 -26.1509              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4029 T22:   0.4174                                     
REMARK   3      T33:   0.1781 T12:   0.1053                                     
REMARK   3      T13:   0.0393 T23:  -0.0454                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.5197 L22:  -0.0261                                     
REMARK   3      L33:   3.6320 L12:  -0.6898                                     
REMARK   3      L13:   1.2134 L23:  -0.4664                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1618 S12:   0.1433 S13:   0.1873                       
REMARK   3      S21:  -0.0868 S22:  -0.0067 S23:  -0.0555                       
REMARK   3      S31:   0.1913 S32:   0.5302 S33:  -0.1551                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   C   107        C   148                          
REMARK   3    ORIGIN FOR THE GROUP (A):  62.8440 -43.2727 -20.3442              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3667 T22:   0.3450                                     
REMARK   3      T33:   0.2348 T12:  -0.0060                                     
REMARK   3      T13:   0.0267 T23:  -0.0054                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.5707 L22:   3.6408                                     
REMARK   3      L33:   2.3217 L12:  -1.9340                                     
REMARK   3      L13:   0.5627 L23:  -1.2424                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1622 S12:  -0.0145 S13:   0.0305                       
REMARK   3      S21:   0.0850 S22:  -0.1048 S23:   0.3655                       
REMARK   3      S31:   0.1258 S32:   0.2369 S33:  -0.0574                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   C   157        C   194                          
REMARK   3    ORIGIN FOR THE GROUP (A):  63.6968 -41.6410 -12.5091              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3213 T22:   0.3289                                     
REMARK   3      T33:   0.1621 T12:  -0.0192                                     
REMARK   3      T13:   0.0149 T23:   0.0153                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.2848 L22:  -2.3622                                     
REMARK   3      L33:   2.7273 L12:  -2.5047                                     
REMARK   3      L13:   0.8379 L23:   1.4755                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1215 S12:  -0.0174 S13:   0.1223                       
REMARK   3      S21:   0.1101 S22:   0.0984 S23:  -0.2072                       
REMARK   3      S31:   0.1434 S32:  -0.1299 S33:   0.0231                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   C   203        C   255                          
REMARK   3    ORIGIN FOR THE GROUP (A):  76.3469 -36.0797  -5.8147              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3026 T22:   0.4122                                     
REMARK   3      T33:   0.1502 T12:  -0.0018                                     
REMARK   3      T13:  -0.0069 T23:   0.0005                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.8465 L22:   3.5451                                     
REMARK   3      L33:   1.5117 L12:  -0.2167                                     
REMARK   3      L13:   0.2890 L23:   0.8805                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0555 S12:  -0.1885 S13:   0.1508                       
REMARK   3      S21:  -0.0799 S22:  -0.1187 S23:  -0.3281                       
REMARK   3      S31:  -0.1587 S32:   0.3223 S33:   0.0632                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 15                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D     3        D    40                          
REMARK   3    ORIGIN FOR THE GROUP (A):  33.4720 -20.8779 -15.6519              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2984 T22:   0.2600                                     
REMARK   3      T33:   0.1402 T12:   0.0110                                     
REMARK   3      T13:   0.0407 T23:  -0.0275                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.6449 L22:  -0.6031                                     
REMARK   3      L33:   2.6425 L12:  -0.6531                                     
REMARK   3      L13:   0.9934 L23:  -0.4499                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0645 S12:  -0.0087 S13:  -0.0630                       
REMARK   3      S21:   0.0816 S22:   0.0764 S23:   0.0583                       
REMARK   3      S31:   0.1231 S32:  -0.1530 S33:  -0.0120                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 16                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D    41        D    94                          
REMARK   3    ORIGIN FOR THE GROUP (A):  35.2670 -21.6118 -25.4695              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2825 T22:   0.2986                                     
REMARK   3      T33:   0.1350 T12:   0.0605                                     
REMARK   3      T13:  -0.0112 T23:   0.0163                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.3852 L22:  -0.0056                                     
REMARK   3      L33:   2.3202 L12:  -0.6242                                     
REMARK   3      L13:  -1.4751 L23:   0.2810                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0291 S12:   0.2556 S13:  -0.0963                       
REMARK   3      S21:  -0.1588 S22:  -0.1454 S23:  -0.0012                       
REMARK   3      S31:   0.0135 S32:  -0.3127 S33:   0.1163                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 17                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D   109        D   146                          
REMARK   3    ORIGIN FOR THE GROUP (A):  49.8843 -27.0155 -21.7652              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2955 T22:   0.3109                                     
REMARK   3      T33:   0.2045 T12:   0.0222                                     
REMARK   3      T13:   0.0234 T23:  -0.0048                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.6303 L22:   4.2726                                     
REMARK   3      L33:  -0.0675 L12:  -3.5467                                     
REMARK   3      L13:  -0.0490 L23:  -0.1718                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0352 S12:   0.0236 S13:  -0.0708                       
REMARK   3      S21:   0.1198 S22:   0.0850 S23:  -0.0384                       
REMARK   3      S31:   0.0594 S32:  -0.0101 S33:  -0.0498                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 18                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D   156        D   190                          
REMARK   3    ORIGIN FOR THE GROUP (A):  52.5727 -27.5743 -13.5470              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3185 T22:   0.3217                                     
REMARK   3      T33:   0.1896 T12:  -0.0020                                     
REMARK   3      T13:  -0.0074 T23:   0.0526                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.8119 L22:  -2.2399                                     
REMARK   3      L33:   1.7645 L12:   0.3704                                     
REMARK   3      L13:  -1.0615 L23:   1.0347                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0625 S12:  -0.1098 S13:  -0.0060                       
REMARK   3      S21:   0.2112 S22:   0.1118 S23:   0.0488                       
REMARK   3      S31:   0.2848 S32:   0.0234 S33:  -0.0493                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 19                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   D   222        D   251                          
REMARK   3    ORIGIN FOR THE GROUP (A):  42.4105 -22.8982  -4.7099              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3674 T22:   0.3060                                     
REMARK   3      T33:   0.2073 T12:   0.0548                                     
REMARK   3      T13:  -0.0038 T23:   0.0093                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.0198 L22:   0.0266                                     
REMARK   3      L33:   4.1774 L12:  -0.8512                                     
REMARK   3      L13:   1.3318 L23:   0.4086                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1000 S12:  -0.1914 S13:  -0.2260                       
REMARK   3      S21:  -0.2604 S22:  -0.1906 S23:   0.1971                       
REMARK   3      S31:   0.1317 S32:   0.0134 S33:   0.0905                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 20                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E     3        E    30                          
REMARK   3    ORIGIN FOR THE GROUP (A): -13.8903  29.5483  -9.7878              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5269 T22:   0.4044                                     
REMARK   3      T33:   0.2367 T12:   0.1090                                     
REMARK   3      T13:   0.0051 T23:   0.0091                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.2493 L22:   1.2697                                     
REMARK   3      L33:   1.5930 L12:   2.6921                                     
REMARK   3      L13:   0.6760 L23:   0.5202                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0899 S12:   0.0832 S13:   0.0362                       
REMARK   3      S21:  -0.1689 S22:   0.0093 S23:   0.1411                       
REMARK   3      S31:  -0.5310 S32:  -0.1604 S33:  -0.0992                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 21                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E    31        E    61                          
REMARK   3    ORIGIN FOR THE GROUP (A): -18.0628  31.2348 -18.3972              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8343 T22:   0.4513                                     
REMARK   3      T33:   0.3826 T12:   0.2319                                     
REMARK   3      T13:  -0.1851 T23:   0.0571                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.0695 L22:   2.3683                                     
REMARK   3      L33:   4.7502 L12:  -2.9151                                     
REMARK   3      L13:  -0.1368 L23:  -0.8473                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1584 S12:   0.3528 S13:   0.2343                       
REMARK   3      S21:  -0.3572 S22:  -0.1441 S23:   0.2885                       
REMARK   3      S31:  -1.4988 S32:  -0.5847 S33:   0.3025                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 22                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E    62        E    94                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -7.0503  25.1456 -22.8457              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5657 T22:   0.2975                                     
REMARK   3      T33:   0.1505 T12:  -0.0032                                     
REMARK   3      T13:   0.0228 T23:   0.0511                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.2609 L22:   0.6736                                     
REMARK   3      L33:  -0.5862 L12:   0.5365                                     
REMARK   3      L13:  -0.9146 L23:   0.8054                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1408 S12:   0.1731 S13:   0.1637                       
REMARK   3      S21:  -0.1948 S22:   0.1964 S23:  -0.1167                       
REMARK   3      S31:  -0.1410 S32:   0.1132 S33:  -0.3371                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 23                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E   107        E   147                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -5.3743  13.9392 -17.6249              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4224 T22:   0.3879                                     
REMARK   3      T33:   0.1044 T12:  -0.0093                                     
REMARK   3      T13:   0.0247 T23:  -0.0354                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3121 L22:   6.1719                                     
REMARK   3      L33:   1.3162 L12:   1.1135                                     
REMARK   3      L13:   0.3810 L23:   0.6341                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0429 S12:  -0.1800 S13:  -0.0357                       
REMARK   3      S21:  -0.0952 S22:  -0.0051 S23:  -0.1355                       
REMARK   3      S31:  -0.1450 S32:  -0.1423 S33:  -0.0378                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 24                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E   157        E   190                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -2.0315  12.7405  -9.7274              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3791 T22:   0.3464                                     
REMARK   3      T33:   0.1950 T12:  -0.0107                                     
REMARK   3      T13:   0.0231 T23:  -0.0261                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -1.7425 L22:   3.7629                                     
REMARK   3      L33:   2.1771 L12:  -0.4707                                     
REMARK   3      L13:   1.4181 L23:   2.0794                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0753 S12:   0.0169 S13:   0.0153                       
REMARK   3      S21:   0.2039 S22:  -0.0544 S23:   0.0658                       
REMARK   3      S31:  -0.1023 S32:  -0.1308 S33:  -0.0209                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 25                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   E   203        E   256                          
REMARK   3    ORIGIN FOR THE GROUP (A): -14.0042  16.7034   2.2301              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3703 T22:   0.3698                                     
REMARK   3      T33:   0.2939 T12:   0.0038                                     
REMARK   3      T13:  -0.0064 T23:   0.0093                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.6447 L22:   0.6998                                     
REMARK   3      L33:   2.1489 L12:   0.4553                                     
REMARK   3      L13:  -0.9311 L23:   0.4938                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1857 S12:  -0.0790 S13:  -0.1800                       
REMARK   3      S21:  -0.1733 S22:   0.0095 S23:   0.1841                       
REMARK   3      S31:   0.0633 S32:  -0.2707 S33:   0.1762                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 26                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F     3        F    25                          
REMARK   3    ORIGIN FOR THE GROUP (A):   7.1208 -20.4983 -13.2824              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2606 T22:   0.2250                                     
REMARK   3      T33:   0.1184 T12:   0.0285                                     
REMARK   3      T13:   0.0319 T23:  -0.0499                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.4696 L22:   1.1332                                     
REMARK   3      L33:   4.9967 L12:  -1.6419                                     
REMARK   3      L13:   0.2798 L23:  -0.0343                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3118 S12:  -0.0586 S13:   0.1830                       
REMARK   3      S21:   0.3035 S22:   0.0073 S23:   0.3393                       
REMARK   3      S31:   0.1159 S32:  -0.0681 S33:  -0.3191                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 27                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F    26        F    61                          
REMARK   3    ORIGIN FOR THE GROUP (A):   8.3399 -23.8622 -20.0472              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1785 T22:   0.2982                                     
REMARK   3      T33:   0.2183 T12:   0.0818                                     
REMARK   3      T13:  -0.0213 T23:  -0.0937                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.8386 L22:   3.3464                                     
REMARK   3      L33:  11.9451 L12:  -0.7060                                     
REMARK   3      L13:  -1.2268 L23:  -3.5473                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0735 S12:   0.4589 S13:  -0.1405                       
REMARK   3      S21:  -0.1271 S22:  -0.2758 S23:   0.0326                       
REMARK   3      S31:   0.4976 S32:   0.3981 S33:   0.2023                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 28                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F    62        F    94                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -4.1452 -18.2612 -21.7195              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2041 T22:   0.2790                                     
REMARK   3      T33:   0.1017 T12:  -0.0167                                     
REMARK   3      T13:  -0.0319 T23:   0.0263                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.8599 L22:   4.2601                                     
REMARK   3      L33:   4.3466 L12:  -0.2827                                     
REMARK   3      L13:   0.6528 L23:  -1.2112                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0611 S12:   0.0923 S13:  -0.1775                       
REMARK   3      S21:   0.2294 S22:  -0.0386 S23:   0.0886                       
REMARK   3      S31:  -0.2209 S32:  -0.1366 S33:  -0.0225                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 29                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F   109        F   147                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -4.5461  -7.2947 -16.6132              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2769 T22:   0.3646                                     
REMARK   3      T33:   0.2364 T12:  -0.0172                                     
REMARK   3      T13:  -0.0432 T23:   0.0089                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0679 L22:   5.0023                                     
REMARK   3      L33:   2.6923 L12:   1.2708                                     
REMARK   3      L13:  -0.6009 L23:  -0.9889                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0932 S12:   0.0034 S13:  -0.0166                       
REMARK   3      S21:   0.1269 S22:  -0.1748 S23:  -0.0277                       
REMARK   3      S31:  -0.2149 S32:   0.1189 S33:   0.0816                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 30                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F   154        F   191                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -2.4375  -3.9846  -9.0090              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3818 T22:   0.3837                                     
REMARK   3      T33:   0.1647 T12:  -0.0146                                     
REMARK   3      T13:   0.0224 T23:  -0.0524                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.9208 L22:   1.4226                                     
REMARK   3      L33:   3.7120 L12:  -0.5393                                     
REMARK   3      L13:  -1.4676 L23:  -2.2519                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0139 S12:   0.0745 S13:   0.1132                       
REMARK   3      S21:   0.0607 S22:  -0.0158 S23:  -0.1265                       
REMARK   3      S31:  -0.0167 S32:   0.0663 S33:   0.0297                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 31                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   F   222        F   255                          
REMARK   3    ORIGIN FOR THE GROUP (A):   5.8666 -11.9729  -1.3993              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3837 T22:   0.3014                                     
REMARK   3      T33:   0.1241 T12:   0.0750                                     
REMARK   3      T13:  -0.0001 T23:   0.0010                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.3018 L22:   1.8772                                     
REMARK   3      L33:   2.7731 L12:   3.6134                                     
REMARK   3      L13:   0.5185 L23:  -1.3312                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0550 S12:  -0.1212 S13:  -0.0917                       
REMARK   3      S21:   0.1714 S22:  -0.0623 S23:   0.0782                       
REMARK   3      S31:  -0.1851 S32:   0.0411 S33:   0.1173                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 32                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   G     3        G    32                          
REMARK   3    ORIGIN FOR THE GROUP (A):   3.1476 -23.3813  16.6006              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5775 T22:   0.3821                                     
REMARK   3      T33:   0.2120 T12:  -0.0021                                     
REMARK   3      T13:  -0.1149 T23:   0.0263                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.6247 L22:   4.9020                                     
REMARK   3      L33:   1.0602 L12:  -0.7873                                     
REMARK   3      L13:  -1.8910 L23:   0.0396                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0894 S12:  -0.0594 S13:  -0.3585                       
REMARK   3      S21:   0.3274 S22:   0.0431 S23:   0.0618                       
REMARK   3      S31:   0.7145 S32:  -0.0998 S33:  -0.1325                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 33                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   G    33        G    97                          
REMARK   3    ORIGIN FOR THE GROUP (A):   7.2073 -19.7340  26.7446              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5079 T22:   0.4146                                     
REMARK   3      T33:   0.1939 T12:   0.0857                                     
REMARK   3      T13:  -0.0277 T23:   0.0028                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.2625 L22:   2.5867                                     
REMARK   3      L33:   2.5651 L12:   1.4214                                     
REMARK   3      L13:   0.8318 L23:   0.2315                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2289 S12:  -0.0511 S13:  -0.3847                       
REMARK   3      S21:   0.3631 S22:  -0.0729 S23:   0.2580                       
REMARK   3      S31:   0.5126 S32:  -0.1162 S33:  -0.1560                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 34                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   G   109        G   148                          
REMARK   3    ORIGIN FOR THE GROUP (A):   7.4285  -5.2680  21.3825              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3820 T22:   0.3995                                     
REMARK   3      T33:   0.1897 T12:   0.0240                                     
REMARK   3      T13:  -0.0226 T23:   0.0151                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.6615 L22:   2.8816                                     
REMARK   3      L33:   0.1693 L12:  -1.3573                                     
REMARK   3      L13:   0.2134 L23:   0.7997                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0527 S12:   0.4007 S13:  -0.2192                       
REMARK   3      S21:   0.0555 S22:  -0.0485 S23:   0.2579                       
REMARK   3      S31:   0.0366 S32:   0.1812 S33:   0.1012                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 35                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   G   159        G   189                          
REMARK   3    ORIGIN FOR THE GROUP (A):   8.0434  -3.7624  12.9969              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3849 T22:   0.4222                                     
REMARK   3      T33:   0.2426 T12:   0.0217                                     
REMARK   3      T13:  -0.0060 T23:  -0.0252                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -5.5872 L22:   0.4884                                     
REMARK   3      L33:   3.3962 L12:   0.4090                                     
REMARK   3      L13:  -0.5237 L23:  -0.0137                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2752 S12:   0.2698 S13:   0.1076                       
REMARK   3      S21:  -0.0630 S22:  -0.2345 S23:  -0.1752                       
REMARK   3      S31:   0.0364 S32:  -0.3666 S33:  -0.0407                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 36                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   G   203        G   255                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -6.7047 -12.7072   7.1898              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4217 T22:   0.4619                                     
REMARK   3      T33:   0.1926 T12:  -0.0066                                     
REMARK   3      T13:   0.0046 T23:   0.0213                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.3072 L22:   1.4553                                     
REMARK   3      L33:   1.8928 L12:  -0.2781                                     
REMARK   3      L13:   0.1648 L23:   0.0552                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0414 S12:  -0.0417 S13:  -0.2007                       
REMARK   3      S21:   0.2328 S22:  -0.0058 S23:   0.2166                       
REMARK   3      S31:  -0.0365 S32:  -0.4495 S33:   0.0472                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 37                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   H     3        H    40                          
REMARK   3    ORIGIN FOR THE GROUP (A):   2.0322  32.0638  17.0899              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3564 T22:   0.2040                                     
REMARK   3      T33:   0.1141 T12:   0.0022                                     
REMARK   3      T13:   0.0285 T23:  -0.0248                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.8541 L22:   3.0615                                     
REMARK   3      L33:   3.0734 L12:  -2.0442                                     
REMARK   3      L13:   0.7628 L23:  -1.4796                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1797 S12:   0.1743 S13:  -0.1246                       
REMARK   3      S21:   0.0905 S22:  -0.0805 S23:  -0.0361                       
REMARK   3      S31:  -0.2188 S32:   0.0242 S33:  -0.0992                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 38                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   H    41        H    94                          
REMARK   3    ORIGIN FOR THE GROUP (A):   1.5713  30.0414  26.7934              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3641 T22:   0.1775                                     
REMARK   3      T33:   0.0838 T12:   0.0264                                     
REMARK   3      T13:  -0.0447 T23:  -0.0182                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.9044 L22:   2.3856                                     
REMARK   3      L33:   2.9703 L12:   1.5192                                     
REMARK   3      L13:  -1.2886 L23:  -1.4372                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0968 S12:  -0.1016 S13:  -0.0842                       
REMARK   3      S21:   0.3035 S22:  -0.1560 S23:  -0.0174                       
REMARK   3      S31:  -0.3760 S32:   0.0869 S33:   0.0592                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 39                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   H   108        H   147                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -0.2251  14.6375  22.6178              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3552 T22:   0.2629                                     
REMARK   3      T33:   0.2438 T12:  -0.0436                                     
REMARK   3      T13:  -0.0054 T23:  -0.0003                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.5365 L22:   4.8593                                     
REMARK   3      L33:   3.0696 L12:  -3.9564                                     
REMARK   3      L13:   0.9727 L23:  -1.4668                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1259 S12:  -0.0609 S13:  -0.1666                       
REMARK   3      S21:  -0.1873 S22:   0.0315 S23:   0.0424                       
REMARK   3      S31:   0.0297 S32:   0.2284 S33:  -0.1574                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 40                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   H   156        H   193                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -0.9264  12.4942  14.3366              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4271 T22:   0.4997                                     
REMARK   3      T33:   0.2057 T12:   0.0193                                     
REMARK   3      T13:   0.0018 T23:  -0.0259                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.2621 L22:   2.2680                                     
REMARK   3      L33:   0.2327 L12:  -0.0416                                     
REMARK   3      L13:  -0.3544 L23:   0.7376                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2105 S12:   0.1171 S13:  -0.2776                       
REMARK   3      S21:  -0.2563 S22:  -0.2058 S23:  -0.2413                       
REMARK   3      S31:  -0.1232 S32:   0.1383 S33:  -0.0047                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 41                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   H   206        H   255                          
REMARK   3    ORIGIN FOR THE GROUP (A):   5.9458  20.9372   2.9191              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4612 T22:   0.4412                                     
REMARK   3      T33:   0.2665 T12:  -0.0398                                     
REMARK   3      T13:   0.0449 T23:  -0.0219                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.9428 L22:   2.1103                                     
REMARK   3      L33:   2.3302 L12:   0.7287                                     
REMARK   3      L13:  -0.5258 L23:  -0.6575                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1795 S12:   0.3432 S13:  -0.1784                       
REMARK   3      S21:  -0.4025 S22:  -0.0051 S23:  -0.3221                       
REMARK   3      S31:   0.1153 S32:   0.3020 S33:   0.1845                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 42                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   I     3        I    34                          
REMARK   3    ORIGIN FOR THE GROUP (A):  28.3421 -56.2916  16.5908              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5947 T22:   0.7112                                     
REMARK   3      T33:   0.4441 T12:  -0.1236                                     
REMARK   3      T13:   0.0279 T23:  -0.0011                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.7483 L22:   4.9755                                     
REMARK   3      L33:   4.1708 L12:   1.2909                                     
REMARK   3      L13:   0.9742 L23:  -1.0112                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0580 S12:   0.2595 S13:   0.1702                       
REMARK   3      S21:   0.5304 S22:   0.1027 S23:  -0.4298                       
REMARK   3      S31:  -0.3525 S32:   0.7287 S33:  -0.1607                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 43                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   I    35        I    94                          
REMARK   3    ORIGIN FOR THE GROUP (A):  25.8244 -57.5085  28.0907              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7674 T22:   0.6902                                     
REMARK   3      T33:   0.4733 T12:  -0.1437                                     
REMARK   3      T13:  -0.0645 T23:   0.0441                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.1299 L22:   0.2087                                     
REMARK   3      L33:   2.3116 L12:  -0.3304                                     
REMARK   3      L13:  -0.6471 L23:   0.9787                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1126 S12:  -0.2329 S13:  -0.0712                       
REMARK   3      S21:  -0.0389 S22:  -0.0537 S23:  -0.2100                       
REMARK   3      S31:  -0.2089 S32:   0.2953 S33:  -0.0589                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 44                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   I   109        I   146                          
REMARK   3    ORIGIN FOR THE GROUP (A):  11.2590 -62.7420  24.4004              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5913 T22:   0.5253                                     
REMARK   3      T33:   0.4252 T12:  -0.0358                                     
REMARK   3      T13:   0.0170 T23:  -0.0301                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.9323 L22:   2.4814                                     
REMARK   3      L33:   0.5369 L12:   1.3770                                     
REMARK   3      L13:  -0.4420 L23:  -0.6264                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1766 S12:  -0.2931 S13:  -0.0562                       
REMARK   3      S21:   0.0862 S22:  -0.1604 S23:  -0.1748                       
REMARK   3      S31:  -0.2735 S32:   0.0541 S33:  -0.0162                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 45                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   I   157        I   189                          
REMARK   3    ORIGIN FOR THE GROUP (A):   8.3455 -62.8749  16.3172              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6142 T22:   0.4190                                     
REMARK   3      T33:   0.4665 T12:  -0.0103                                     
REMARK   3      T13:  -0.0358 T23:  -0.0082                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.7574 L22:   2.7451                                     
REMARK   3      L33:  -0.2582 L12:   1.2288                                     
REMARK   3      L13:  -0.4324 L23:   0.0281                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2476 S12:   0.0603 S13:  -0.2465                       
REMARK   3      S21:   0.0013 S22:  -0.2418 S23:   0.0675                       
REMARK   3      S31:  -0.1223 S32:   0.0062 S33:  -0.0058                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 46                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   I   205        I   255                          
REMARK   3    ORIGIN FOR THE GROUP (A):  20.7583 -67.2042   4.6122              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4957 T22:   0.5584                                     
REMARK   3      T33:   0.4555 T12:  -0.0429                                     
REMARK   3      T13:  -0.0414 T23:  -0.0314                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.2065 L22:  -0.3789                                     
REMARK   3      L33:   0.5971 L12:   0.8551                                     
REMARK   3      L13:  -0.7082 L23:  -1.1590                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0858 S12:   0.1448 S13:   0.1106                       
REMARK   3      S21:   0.1004 S22:  -0.2105 S23:  -0.0940                       
REMARK   3      S31:   0.0894 S32:  -0.0609 S33:   0.1247                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 47                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   J     3        J    39                          
REMARK   3    ORIGIN FOR THE GROUP (A): -19.7086 -85.9581  19.3607              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4527 T22:   0.4894                                     
REMARK   3      T33:   0.3771 T12:  -0.0839                                     
REMARK   3      T13:  -0.0394 T23:   0.1469                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.1455 L22:   3.1111                                     
REMARK   3      L33:   7.2412 L12:  -0.1117                                     
REMARK   3      L13:   0.2892 L23:   4.1871                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2494 S12:  -0.2440 S13:   0.1819                       
REMARK   3      S21:  -0.1697 S22:   0.3299 S23:   0.0552                       
REMARK   3      S31:   0.1676 S32:  -0.4240 S33:  -0.5794                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 48                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   J    40        J    93                          
REMARK   3    ORIGIN FOR THE GROUP (A): -15.3056 -87.3226  28.9742              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5579 T22:   0.5203                                     
REMARK   3      T33:   0.3958 T12:  -0.1003                                     
REMARK   3      T13:  -0.0175 T23:   0.0541                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.4066 L22:   4.3378                                     
REMARK   3      L33:   1.2785 L12:  -1.1863                                     
REMARK   3      L13:  -0.2744 L23:   0.3392                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0654 S12:  -0.2930 S13:  -0.0532                       
REMARK   3      S21:   0.1524 S22:   0.1215 S23:   0.3858                       
REMARK   3      S31:   0.0548 S32:  -0.4124 S33:  -0.1868                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 49                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   J   109        J   146                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -1.7563 -80.9142  23.3919              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5790 T22:   0.4796                                     
REMARK   3      T33:   0.3811 T12:  -0.0121                                     
REMARK   3      T13:  -0.0627 T23:   0.0401                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.3010 L22:   1.4411                                     
REMARK   3      L33:   0.6014 L12:   2.6909                                     
REMARK   3      L13:   0.8678 L23:   1.2606                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1882 S12:  -0.0199 S13:   0.1235                       
REMARK   3      S21:   0.0367 S22:  -0.1056 S23:  -0.0823                       
REMARK   3      S31:  -0.0521 S32:   0.0431 S33:  -0.0826                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 50                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   J   159        J   190                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -0.8072 -80.1942  14.6488              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5357 T22:   0.4590                                     
REMARK   3      T33:   0.4438 T12:   0.0028                                     
REMARK   3      T13:  -0.0374 T23:  -0.0354                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.8431 L22:  -3.8552                                     
REMARK   3      L33:   4.1017 L12:   0.5107                                     
REMARK   3      L13:   0.0482 L23:   0.5473                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0648 S12:   0.0754 S13:  -0.0150                       
REMARK   3      S21:  -0.0873 S22:   0.0063 S23:   0.0813                       
REMARK   3      S31:  -0.1037 S32:   0.1355 S33:   0.0584                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 51                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   J   205        J   253                          
REMARK   3    ORIGIN FOR THE GROUP (A): -15.0988 -72.5496   7.8199              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5698 T22:   0.5660                                     
REMARK   3      T33:   0.4632 T12:  -0.0070                                     
REMARK   3      T13:   0.0822 T23:   0.0082                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.1401 L22:  -0.6416                                     
REMARK   3      L33:   2.7017 L12:  -1.2237                                     
REMARK   3      L13:   1.2402 L23:   0.7472                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0943 S12:   0.0165 S13:  -0.0137                       
REMARK   3      S21:  -0.0367 S22:  -0.0728 S23:   0.0701                       
REMARK   3      S31:  -0.3355 S32:  -0.1954 S33:  -0.0215                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 52                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   K     3        K    68                          
REMARK   3    ORIGIN FOR THE GROUP (A): -16.5339 -89.1871 -16.7581              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7001 T22:   0.7348                                     
REMARK   3      T33:   0.5303 T12:  -0.0986                                     
REMARK   3      T13:  -0.0902 T23:  -0.0643                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.8797 L22:  -0.7582                                     
REMARK   3      L33:   3.3992 L12:  -1.4041                                     
REMARK   3      L13:  -0.0809 L23:  -0.3556                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1150 S12:   0.2422 S13:  -0.2818                       
REMARK   3      S21:  -0.1875 S22:   0.0104 S23:   0.1365                       
REMARK   3      S31:   0.4642 S32:  -0.2110 S33:  -0.1254                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 53                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   K    69        K    94                          
REMARK   3    ORIGIN FOR THE GROUP (A): -19.6625 -77.1609 -19.6174              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3609 T22:   0.7653                                     
REMARK   3      T33:   0.3428 T12:  -0.1010                                     
REMARK   3      T13:  -0.0853 T23:   0.0743                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.5230 L22:   4.7852                                     
REMARK   3      L33:   2.1015 L12:  -0.6577                                     
REMARK   3      L13:  -1.6808 L23:  -1.5577                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0742 S12:   0.0188 S13:  -0.1101                       
REMARK   3      S21:  -0.2290 S22:   0.2210 S23:  -0.0064                       
REMARK   3      S31:   0.2836 S32:  -0.1537 S33:  -0.1468                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 54                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   K   109        K   148                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -8.7646 -72.6538 -15.1457              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5713 T22:   0.7093                                     
REMARK   3      T33:   0.4692 T12:  -0.0305                                     
REMARK   3      T13:  -0.0136 T23:   0.0623                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.0549 L22:  -0.0441                                     
REMARK   3      L33:   0.2831 L12:   1.1063                                     
REMARK   3      L13:   1.3062 L23:   0.6879                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0499 S12:  -0.0671 S13:  -0.0619                       
REMARK   3      S21:  -0.1683 S22:   0.1426 S23:  -0.1023                       
REMARK   3      S31:   0.1595 S32:  -0.2346 S33:  -0.0927                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 55                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   K   157        K   190                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -7.0195 -71.2511  -7.3359              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4047 T22:   0.5142                                     
REMARK   3      T33:   0.3844 T12:  -0.0034                                     
REMARK   3      T13:   0.0120 T23:  -0.0031                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.8033 L22:   0.9429                                     
REMARK   3      L33:   1.6021 L12:  -1.3171                                     
REMARK   3      L13:  -2.6592 L23:   1.0714                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1824 S12:  -0.0095 S13:   0.2256                       
REMARK   3      S21:   0.0900 S22:  -0.0360 S23:  -0.0947                       
REMARK   3      S31:  -0.1597 S32:  -0.0984 S33:  -0.1464                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 56                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   K   204        K   255                          
REMARK   3    ORIGIN FOR THE GROUP (A):  -2.6149 -86.4884  -0.1941              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5777 T22:   0.6291                                     
REMARK   3      T33:   0.4655 T12:   0.0155                                     
REMARK   3      T13:  -0.0134 T23:  -0.0581                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.4848 L22:   1.4377                                     
REMARK   3      L33:   1.1387 L12:  -0.8344                                     
REMARK   3      L13:   0.7177 L23:  -1.4665                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0769 S12:   0.1063 S13:   0.1657                       
REMARK   3      S21:   0.0301 S22:  -0.0695 S23:  -0.1917                       
REMARK   3      S31:   0.3216 S32:   0.0912 S33:   0.1464                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 57                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   L     3        L    30                          
REMARK   3    ORIGIN FOR THE GROUP (A):  18.3695 -46.0179  -8.7724              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5925 T22:   0.4467                                     
REMARK   3      T33:   0.3479 T12:  -0.0553                                     
REMARK   3      T13:   0.0418 T23:   0.1011                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.6152 L22:   4.1567                                     
REMARK   3      L33:   4.2166 L12:  -5.0877                                     
REMARK   3      L13:   2.3998 L23:   2.0155                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1635 S12:  -0.1225 S13:  -0.0151                       
REMARK   3      S21:  -0.0024 S22:   0.0423 S23:  -0.1117                       
REMARK   3      S31:  -0.1871 S32:  -0.2096 S33:  -0.2058                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 58                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   L    31        L    61                          
REMARK   3    ORIGIN FOR THE GROUP (A):  17.9582 -41.8686 -17.5651              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5570 T22:   0.5613                                     
REMARK   3      T33:   0.4725 T12:  -0.1083                                     
REMARK   3      T13:   0.1126 T23:   0.0327                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.7167 L22:   2.2444                                     
REMARK   3      L33:   7.2013 L12:   0.3564                                     
REMARK   3      L13:   7.0608 L23:   2.6139                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2210 S12:   0.2784 S13:   0.3929                       
REMARK   3      S21:  -0.2365 S22:  -0.4409 S23:   0.0348                       
REMARK   3      S31:  -0.1202 S32:   0.3272 S33:   0.2198                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 59                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   L    62        L    94                          
REMARK   3    ORIGIN FOR THE GROUP (A):  18.3237 -54.5551 -21.5284              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4703 T22:   0.4776                                     
REMARK   3      T33:   0.4233 T12:  -0.0480                                     
REMARK   3      T13:  -0.0327 T23:  -0.0507                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.2637 L22:   0.7347                                     
REMARK   3      L33:   3.0949 L12:  -0.5877                                     
REMARK   3      L13:  -0.2754 L23:  -1.0438                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2790 S12:   0.3351 S13:   0.0442                       
REMARK   3      S21:  -0.2149 S22:  -0.0558 S23:   0.1932                       
REMARK   3      S31:   0.0070 S32:   0.1362 S33:   0.3348                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 60                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   L   108        L   146                          
REMARK   3    ORIGIN FOR THE GROUP (A):   9.7591 -61.8469 -16.3784              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4560 T22:   0.4196                                     
REMARK   3      T33:   0.3333 T12:  -0.0215                                     
REMARK   3      T13:   0.0355 T23:  -0.1150                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.3785 L22:   1.0776                                     
REMARK   3      L33:   0.9002 L12:  -1.0336                                     
REMARK   3      L13:  -0.3018 L23:  -1.5456                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1351 S12:  -0.3907 S13:  -0.0531                       
REMARK   3      S21:  -0.1537 S22:   0.1007 S23:  -0.0205                       
REMARK   3      S31:   0.1087 S32:  -0.1226 S33:   0.0344                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 61                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   L   159        L   189                          
REMARK   3    ORIGIN FOR THE GROUP (A):  11.5956 -65.2133  -8.3140              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3920 T22:   0.4519                                     
REMARK   3      T33:   0.4491 T12:   0.0400                                     
REMARK   3      T13:  -0.0113 T23:  -0.0251                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -1.5599 L22:   2.4889                                     
REMARK   3      L33:  -0.1069 L12:   1.6128                                     
REMARK   3      L13:  -0.2342 L23:  -0.4958                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0685 S12:  -0.0389 S13:  -0.1944                       
REMARK   3      S21:  -0.0922 S22:   0.1718 S23:   0.0700                       
REMARK   3      S31:  -0.1032 S32:  -0.1022 S33:  -0.1032                       
REMARK   3                                                                      
REMARK   3   TLS GROUP : 62                                                     
REMARK   3    NUMBER OF COMPONENTS GROUP : 1                                    
REMARK   3    COMPONENTS        C SSSEQI   TO  C SSSEQI                         
REMARK   3    RESIDUE RANGE :   L   222        L   252                          
REMARK   3    ORIGIN FOR THE GROUP (A):  14.4303 -54.8086   0.6971              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5035 T22:   0.4791                                     
REMARK   3      T33:   0.4212 T12:  -0.0278                                     
REMARK   3      T13:   0.0533 T23:  -0.0008                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.5593 L22:   2.7247                                     
REMARK   3      L33:   2.1848 L12:  -0.4353                                     
REMARK   3      L13:  -0.1669 L23:  -1.3486                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3198 S12:  -0.2298 S13:   0.0340                       
REMARK   3      S21:   0.4127 S22:   0.3164 S23:   0.0775                       
REMARK   3      S31:  -0.1792 S32:  -0.2720 S33:   0.0034                       
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED : MASK                                                 
REMARK   3   PARAMETERS FOR MASK CALCULATION                                    
REMARK   3   VDW PROBE RADIUS   : 1.40                                          
REMARK   3   ION PROBE RADIUS   : 0.80                                          
REMARK   3   SHRINKAGE RADIUS   : 0.80                                          
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE          
REMARK   3   RIDING POSITIONS.                                                  
REMARK   4                                                                      
REMARK   4 4ALN COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 05-MAR-12.                  
REMARK 100 THE PDBE ID CODE IS EBI-51446.                                       
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 05-FEB-10                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : NULL                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : ESRF                               
REMARK 200  BEAMLINE                       : ID29                               
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.919                              
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : PIXEL                              
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M                 
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : XSCALE                             
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 61623                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.05                               
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.00                              
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.0                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.3                               
REMARK 200  DATA REDUNDANCY                : 2.6                                
REMARK 200  R MERGE                    (I) : 0.12                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 6.76                               
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.05                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.20                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 99.7                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.6                                
REMARK 200  R MERGE FOR SHELL          (I) : 0.50                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 2.12                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: PDB ENTRY 4ALL                                       
REMARK 200                                                                      
REMARK 200 REMARK: NONE                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS  (%): 58.59                                      
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.99                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.61 M NH4H2PO4, 9% T-BUTANOL,           
REMARK 280  0.01 M EDTA PH 7.0                                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 32                             
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -Y,X-Y,Z+2/3                                            
REMARK 290       3555   -X+Y,-X,Z+1/3                                           
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000      126.74000            
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       63.37000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2, 3                                                 
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 9410 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 36030 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -51.8 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 9680 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 36660 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -50.8 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E, F, G, H                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 3                                                       
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 8830 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 35930 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -46.7 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: I, J, K, L                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 400                                                                      
REMARK 400 COMPOUND                                                             
REMARK 400 ENGINEERED RESIDUE IN CHAIN A, LEU 2 TO VAL                          
REMARK 400 ENGINEERED RESIDUE IN CHAIN B, LEU 2 TO VAL                          
REMARK 400 ENGINEERED RESIDUE IN CHAIN C, LEU 2 TO VAL                          
REMARK 400 ENGINEERED RESIDUE IN CHAIN D, LEU 2 TO VAL                          
REMARK 400 ENGINEERED RESIDUE IN CHAIN E, LEU 2 TO VAL                          
REMARK 400 ENGINEERED RESIDUE IN CHAIN F, LEU 2 TO VAL                          
REMARK 400 ENGINEERED RESIDUE IN CHAIN G, LEU 2 TO VAL                          
REMARK 400 ENGINEERED RESIDUE IN CHAIN H, LEU 2 TO VAL                          
REMARK 400 ENGINEERED RESIDUE IN CHAIN I, LEU 2 TO VAL                          
REMARK 400 ENGINEERED RESIDUE IN CHAIN J, LEU 2 TO VAL                          
REMARK 400 ENGINEERED RESIDUE IN CHAIN K, LEU 2 TO VAL                          
REMARK 400 ENGINEERED RESIDUE IN CHAIN L, LEU 2 TO VAL                          
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A   -25                                                      
REMARK 465     LYS A   -24                                                      
REMARK 465     HIS A   -23                                                      
REMARK 465     HIS A   -22                                                      
REMARK 465     HIS A   -21                                                      
REMARK 465     HIS A   -20                                                      
REMARK 465     HIS A   -19                                                      
REMARK 465     HIS A   -18                                                      
REMARK 465     PRO A   -17                                                      
REMARK 465     MET A   -16                                                      
REMARK 465     SER A   -15                                                      
REMARK 465     ASP A   -14                                                      
REMARK 465     TYR A   -13                                                      
REMARK 465     ASP A   -12                                                      
REMARK 465     ILE A   -11                                                      
REMARK 465     PRO A   -10                                                      
REMARK 465     THR A    -9                                                      
REMARK 465     THR A    -8                                                      
REMARK 465     GLU A    -7                                                      
REMARK 465     ASN A    -6                                                      
REMARK 465     LEU A    -5                                                      
REMARK 465     TYR A    -4                                                      
REMARK 465     PHE A    -3                                                      
REMARK 465     GLN A    -2                                                      
REMARK 465     GLY A    -1                                                      
REMARK 465     ALA A     0                                                      
REMARK 465     MET A     1                                                      
REMARK 465     VAL A     2                                                      
REMARK 465     MET A    99                                                      
REMARK 465     GLU A   100                                                      
REMARK 465     ASP A   101                                                      
REMARK 465     LEU A   102                                                      
REMARK 465     ARG A   103                                                      
REMARK 465     GLY A   104                                                      
REMARK 465     ARG A   105                                                      
REMARK 465     PHE A   106                                                      
REMARK 465     LEU A   148                                                      
REMARK 465     GLY A   149                                                      
REMARK 465     GLY A   150                                                      
REMARK 465     GLU A   151                                                      
REMARK 465     PHE A   152                                                      
REMARK 465     ALA A   153                                                      
REMARK 465     THR A   195                                                      
REMARK 465     LEU A   196                                                      
REMARK 465     SER A   197                                                      
REMARK 465     ALA A   198                                                      
REMARK 465     LYS A   199                                                      
REMARK 465     GLY A   200                                                      
REMARK 465     VAL A   201                                                      
REMARK 465     GLY A   202                                                      
REMARK 465     GLY A   203                                                      
REMARK 465     PHE A   204                                                      
REMARK 465     LYS A   256                                                      
REMARK 465     MET B   -25                                                      
REMARK 465     LYS B   -24                                                      
REMARK 465     HIS B   -23                                                      
REMARK 465     HIS B   -22                                                      
REMARK 465     HIS B   -21                                                      
REMARK 465     HIS B   -20                                                      
REMARK 465     HIS B   -19                                                      
REMARK 465     HIS B   -18                                                      
REMARK 465     PRO B   -17                                                      
REMARK 465     MET B   -16                                                      
REMARK 465     SER B   -15                                                      
REMARK 465     ASP B   -14                                                      
REMARK 465     TYR B   -13                                                      
REMARK 465     ASP B   -12                                                      
REMARK 465     ILE B   -11                                                      
REMARK 465     PRO B   -10                                                      
REMARK 465     THR B    -9                                                      
REMARK 465     THR B    -8                                                      
REMARK 465     GLU B    -7                                                      
REMARK 465     ASN B    -6                                                      
REMARK 465     LEU B    -5                                                      
REMARK 465     TYR B    -4                                                      
REMARK 465     PHE B    -3                                                      
REMARK 465     GLN B    -2                                                      
REMARK 465     GLY B    -1                                                      
REMARK 465     ALA B     0                                                      
REMARK 465     MET B     1                                                      
REMARK 465     VAL B     2                                                      
REMARK 465     ALA B    97                                                      
REMARK 465     ASN B    98                                                      
REMARK 465     MET B    99                                                      
REMARK 465     GLU B   100                                                      
REMARK 465     ASP B   101                                                      
REMARK 465     LEU B   102                                                      
REMARK 465     ARG B   103                                                      
REMARK 465     GLY B   104                                                      
REMARK 465     ARG B   105                                                      
REMARK 465     PHE B   106                                                      
REMARK 465     SER B   107                                                      
REMARK 465     GLU B   108                                                      
REMARK 465     TYR B   147                                                      
REMARK 465     LEU B   148                                                      
REMARK 465     GLY B   149                                                      
REMARK 465     GLY B   150                                                      
REMARK 465     GLU B   151                                                      
REMARK 465     PHE B   152                                                      
REMARK 465     ALA B   153                                                      
REMARK 465     VAL B   154                                                      
REMARK 465     GLN B   155                                                      
REMARK 465     ASN B   156                                                      
REMARK 465     TYR B   157                                                      
REMARK 465     THR B   195                                                      
REMARK 465     LEU B   196                                                      
REMARK 465     SER B   197                                                      
REMARK 465     ALA B   198                                                      
REMARK 465     LYS B   199                                                      
REMARK 465     GLY B   200                                                      
REMARK 465     VAL B   201                                                      
REMARK 465     GLY B   202                                                      
REMARK 465     GLY B   203                                                      
REMARK 465     PHE B   204                                                      
REMARK 465     LYS B   256                                                      
REMARK 465     MET C   -25                                                      
REMARK 465     LYS C   -24                                                      
REMARK 465     HIS C   -23                                                      
REMARK 465     HIS C   -22                                                      
REMARK 465     HIS C   -21                                                      
REMARK 465     HIS C   -20                                                      
REMARK 465     HIS C   -19                                                      
REMARK 465     HIS C   -18                                                      
REMARK 465     PRO C   -17                                                      
REMARK 465     MET C   -16                                                      
REMARK 465     SER C   -15                                                      
REMARK 465     ASP C   -14                                                      
REMARK 465     TYR C   -13                                                      
REMARK 465     ASP C   -12                                                      
REMARK 465     ILE C   -11                                                      
REMARK 465     PRO C   -10                                                      
REMARK 465     THR C    -9                                                      
REMARK 465     THR C    -8                                                      
REMARK 465     GLU C    -7                                                      
REMARK 465     ASN C    -6                                                      
REMARK 465     LEU C    -5                                                      
REMARK 465     TYR C    -4                                                      
REMARK 465     PHE C    -3                                                      
REMARK 465     GLN C    -2                                                      
REMARK 465     GLY C    -1                                                      
REMARK 465     ALA C     0                                                      
REMARK 465     MET C     1                                                      
REMARK 465     VAL C     2                                                      
REMARK 465     ALA C    95                                                      
REMARK 465     PHE C    96                                                      
REMARK 465     ALA C    97                                                      
REMARK 465     ASN C    98                                                      
REMARK 465     MET C    99                                                      
REMARK 465     GLU C   100                                                      
REMARK 465     ASP C   101                                                      
REMARK 465     LEU C   102                                                      
REMARK 465     ARG C   103                                                      
REMARK 465     GLY C   104                                                      
REMARK 465     ARG C   105                                                      
REMARK 465     PHE C   106                                                      
REMARK 465     GLY C   149                                                      
REMARK 465     GLY C   150                                                      
REMARK 465     GLU C   151                                                      
REMARK 465     PHE C   152                                                      
REMARK 465     ALA C   153                                                      
REMARK 465     VAL C   154                                                      
REMARK 465     GLN C   155                                                      
REMARK 465     ASN C   156                                                      
REMARK 465     THR C   195                                                      
REMARK 465     LEU C   196                                                      
REMARK 465     SER C   197                                                      
REMARK 465     ALA C   198                                                      
REMARK 465     LYS C   199                                                      
REMARK 465     GLY C   200                                                      
REMARK 465     VAL C   201                                                      
REMARK 465     GLY C   202                                                      
REMARK 465     LYS C   256                                                      
REMARK 465     MET D   -25                                                      
REMARK 465     LYS D   -24                                                      
REMARK 465     HIS D   -23                                                      
REMARK 465     HIS D   -22                                                      
REMARK 465     HIS D   -21                                                      
REMARK 465     HIS D   -20                                                      
REMARK 465     HIS D   -19                                                      
REMARK 465     HIS D   -18                                                      
REMARK 465     PRO D   -17                                                      
REMARK 465     MET D   -16                                                      
REMARK 465     SER D   -15                                                      
REMARK 465     ASP D   -14                                                      
REMARK 465     TYR D   -13                                                      
REMARK 465     ASP D   -12                                                      
REMARK 465     ILE D   -11                                                      
REMARK 465     PRO D   -10                                                      
REMARK 465     THR D    -9                                                      
REMARK 465     THR D    -8                                                      
REMARK 465     GLU D    -7                                                      
REMARK 465     ASN D    -6                                                      
REMARK 465     LEU D    -5                                                      
REMARK 465     TYR D    -4                                                      
REMARK 465     PHE D    -3                                                      
REMARK 465     GLN D    -2                                                      
REMARK 465     GLY D    -1                                                      
REMARK 465     ALA D     0                                                      
REMARK 465     MET D     1                                                      
REMARK 465     VAL D     2                                                      
REMARK 465     ALA D    95                                                      
REMARK 465     PHE D    96                                                      
REMARK 465     ALA D    97                                                      
REMARK 465     ASN D    98                                                      
REMARK 465     MET D    99                                                      
REMARK 465     GLU D   100                                                      
REMARK 465     ASP D   101                                                      
REMARK 465     LEU D   102                                                      
REMARK 465     ARG D   103                                                      
REMARK 465     GLY D   104                                                      
REMARK 465     ARG D   105                                                      
REMARK 465     PHE D   106                                                      
REMARK 465     SER D   107                                                      
REMARK 465     GLU D   108                                                      
REMARK 465     TYR D   147                                                      
REMARK 465     LEU D   148                                                      
REMARK 465     GLY D   149                                                      
REMARK 465     GLY D   150                                                      
REMARK 465     GLU D   151                                                      
REMARK 465     PHE D   152                                                      
REMARK 465     ALA D   153                                                      
REMARK 465     VAL D   154                                                      
REMARK 465     GLN D   155                                                      
REMARK 465     GLY D   191                                                      
REMARK 465     PRO D   192                                                      
REMARK 465     ILE D   193                                                      
REMARK 465     ARG D   194                                                      
REMARK 465     THR D   195                                                      
REMARK 465     LEU D   196                                                      
REMARK 465     SER D   197                                                      
REMARK 465     ALA D   198                                                      
REMARK 465     LYS D   199                                                      
REMARK 465     GLY D   200                                                      
REMARK 465     VAL D   201                                                      
REMARK 465     GLY D   202                                                      
REMARK 465     GLY D   203                                                      
REMARK 465     PHE D   204                                                      
REMARK 465     ASN D   205                                                      
REMARK 465     THR D   206                                                      
REMARK 465     ILE D   207                                                      
REMARK 465     LEU D   208                                                      
REMARK 465     LYS D   209                                                      
REMARK 465     GLU D   210                                                      
REMARK 465     ILE D   211                                                      
REMARK 465     GLU D   212                                                      
REMARK 465     GLU D   213                                                      
REMARK 465     ARG D   214                                                      
REMARK 465     ALA D   215                                                      
REMARK 465     PRO D   216                                                      
REMARK 465     LEU D   217                                                      
REMARK 465     LYS D   218                                                      
REMARK 465     ARG D   219                                                      
REMARK 465     ASN D   220                                                      
REMARK 465     VAL D   221                                                      
REMARK 465     PHE D   252                                                      
REMARK 465     HIS D   253                                                      
REMARK 465     ALA D   254                                                      
REMARK 465     ILE D   255                                                      
REMARK 465     LYS D   256                                                      
REMARK 465     MET E   -25                                                      
REMARK 465     LYS E   -24                                                      
REMARK 465     HIS E   -23                                                      
REMARK 465     HIS E   -22                                                      
REMARK 465     HIS E   -21                                                      
REMARK 465     HIS E   -20                                                      
REMARK 465     HIS E   -19                                                      
REMARK 465     HIS E   -18                                                      
REMARK 465     PRO E   -17                                                      
REMARK 465     MET E   -16                                                      
REMARK 465     SER E   -15                                                      
REMARK 465     ASP E   -14                                                      
REMARK 465     TYR E   -13                                                      
REMARK 465     ASP E   -12                                                      
REMARK 465     ILE E   -11                                                      
REMARK 465     PRO E   -10                                                      
REMARK 465     THR E    -9                                                      
REMARK 465     THR E    -8                                                      
REMARK 465     GLU E    -7                                                      
REMARK 465     ASN E    -6                                                      
REMARK 465     LEU E    -5                                                      
REMARK 465     TYR E    -4                                                      
REMARK 465     PHE E    -3                                                      
REMARK 465     GLN E    -2                                                      
REMARK 465     GLY E    -1                                                      
REMARK 465     ALA E     0                                                      
REMARK 465     MET E     1                                                      
REMARK 465     VAL E     2                                                      
REMARK 465     ALA E    95                                                      
REMARK 465     PHE E    96                                                      
REMARK 465     ALA E    97                                                      
REMARK 465     ASN E    98                                                      
REMARK 465     MET E    99                                                      
REMARK 465     GLU E   100                                                      
REMARK 465     ASP E   101                                                      
REMARK 465     LEU E   102                                                      
REMARK 465     ARG E   103                                                      
REMARK 465     GLY E   104                                                      
REMARK 465     ARG E   105                                                      
REMARK 465     PHE E   106                                                      
REMARK 465     LEU E   148                                                      
REMARK 465     GLY E   149                                                      
REMARK 465     GLY E   150                                                      
REMARK 465     GLU E   151                                                      
REMARK 465     PHE E   152                                                      
REMARK 465     ALA E   153                                                      
REMARK 465     VAL E   154                                                      
REMARK 465     GLN E   155                                                      
REMARK 465     ASN E   156                                                      
REMARK 465     GLY E   191                                                      
REMARK 465     PRO E   192                                                      
REMARK 465     ILE E   193                                                      
REMARK 465     ARG E   194                                                      
REMARK 465     THR E   195                                                      
REMARK 465     LEU E   196                                                      
REMARK 465     SER E   197                                                      
REMARK 465     ALA E   198                                                      
REMARK 465     LYS E   199                                                      
REMARK 465     GLY E   200                                                      
REMARK 465     VAL E   201                                                      
REMARK 465     GLY E   202                                                      
REMARK 465     MET F   -25                                                      
REMARK 465     LYS F   -24                                                      
REMARK 465     HIS F   -23                                                      
REMARK 465     HIS F   -22                                                      
REMARK 465     HIS F   -21                                                      
REMARK 465     HIS F   -20                                                      
REMARK 465     HIS F   -19                                                      
REMARK 465     HIS F   -18                                                      
REMARK 465     PRO F   -17                                                      
REMARK 465     MET F   -16                                                      
REMARK 465     SER F   -15                                                      
REMARK 465     ASP F   -14                                                      
REMARK 465     TYR F   -13                                                      
REMARK 465     ASP F   -12                                                      
REMARK 465     ILE F   -11                                                      
REMARK 465     PRO F   -10                                                      
REMARK 465     THR F    -9                                                      
REMARK 465     THR F    -8                                                      
REMARK 465     GLU F    -7                                                      
REMARK 465     ASN F    -6                                                      
REMARK 465     LEU F    -5                                                      
REMARK 465     TYR F    -4                                                      
REMARK 465     PHE F    -3                                                      
REMARK 465     GLN F    -2                                                      
REMARK 465     GLY F    -1                                                      
REMARK 465     ALA F     0                                                      
REMARK 465     MET F     1                                                      
REMARK 465     VAL F     2                                                      
REMARK 465     ALA F    95                                                      
REMARK 465     PHE F    96                                                      
REMARK 465     ALA F    97                                                      
REMARK 465     ASN F    98                                                      
REMARK 465     MET F    99                                                      
REMARK 465     GLU F   100                                                      
REMARK 465     ASP F   101                                                      
REMARK 465     LEU F   102                                                      
REMARK 465     ARG F   103                                                      
REMARK 465     GLY F   104                                                      
REMARK 465     ARG F   105                                                      
REMARK 465     PHE F   106                                                      
REMARK 465     SER F   107                                                      
REMARK 465     GLU F   108                                                      
REMARK 465     LEU F   148                                                      
REMARK 465     GLY F   149                                                      
REMARK 465     GLY F   150                                                      
REMARK 465     GLU F   151                                                      
REMARK 465     PHE F   152                                                      
REMARK 465     ALA F   153                                                      
REMARK 465     PRO F   192                                                      
REMARK 465     ILE F   193                                                      
REMARK 465     ARG F   194                                                      
REMARK 465     THR F   195                                                      
REMARK 465     LEU F   196                                                      
REMARK 465     SER F   197                                                      
REMARK 465     ALA F   198                                                      
REMARK 465     LYS F   199                                                      
REMARK 465     GLY F   200                                                      
REMARK 465     VAL F   201                                                      
REMARK 465     GLY F   202                                                      
REMARK 465     GLY F   203                                                      
REMARK 465     PHE F   204                                                      
REMARK 465     ASN F   205                                                      
REMARK 465     THR F   206                                                      
REMARK 465     ILE F   207                                                      
REMARK 465     LEU F   208                                                      
REMARK 465     LYS F   209                                                      
REMARK 465     GLU F   210                                                      
REMARK 465     ILE F   211                                                      
REMARK 465     GLU F   212                                                      
REMARK 465     GLU F   213                                                      
REMARK 465     ARG F   214                                                      
REMARK 465     ALA F   215                                                      
REMARK 465     PRO F   216                                                      
REMARK 465     LEU F   217                                                      
REMARK 465     LYS F   218                                                      
REMARK 465     ARG F   219                                                      
REMARK 465     ASN F   220                                                      
REMARK 465     VAL F   221                                                      
REMARK 465     LYS F   256                                                      
REMARK 465     MET G   -25                                                      
REMARK 465     LYS G   -24                                                      
REMARK 465     HIS G   -23                                                      
REMARK 465     HIS G   -22                                                      
REMARK 465     HIS G   -21                                                      
REMARK 465     HIS G   -20                                                      
REMARK 465     HIS G   -19                                                      
REMARK 465     HIS G   -18                                                      
REMARK 465     PRO G   -17                                                      
REMARK 465     MET G   -16                                                      
REMARK 465     SER G   -15                                                      
REMARK 465     ASP G   -14                                                      
REMARK 465     TYR G   -13                                                      
REMARK 465     ASP G   -12                                                      
REMARK 465     ILE G   -11                                                      
REMARK 465     PRO G   -10                                                      
REMARK 465     THR G    -9                                                      
REMARK 465     THR G    -8                                                      
REMARK 465     GLU G    -7                                                      
REMARK 465     ASN G    -6                                                      
REMARK 465     LEU G    -5                                                      
REMARK 465     TYR G    -4                                                      
REMARK 465     PHE G    -3                                                      
REMARK 465     GLN G    -2                                                      
REMARK 465     GLY G    -1                                                      
REMARK 465     ALA G     0                                                      
REMARK 465     MET G     1                                                      
REMARK 465     VAL G     2                                                      
REMARK 465     ASN G    98                                                      
REMARK 465     MET G    99                                                      
REMARK 465     GLU G   100                                                      
REMARK 465     ASP G   101                                                      
REMARK 465     LEU G   102                                                      
REMARK 465     ARG G   103                                                      
REMARK 465     GLY G   104                                                      
REMARK 465     ARG G   105                                                      
REMARK 465     PHE G   106                                                      
REMARK 465     SER G   107                                                      
REMARK 465     GLU G   108                                                      
REMARK 465     GLY G   149                                                      
REMARK 465     GLY G   150                                                      
REMARK 465     GLU G   151                                                      
REMARK 465     PHE G   152                                                      
REMARK 465     ALA G   153                                                      
REMARK 465     VAL G   154                                                      
REMARK 465     GLN G   155                                                      
REMARK 465     ASN G   156                                                      
REMARK 465     ALA G   190                                                      
REMARK 465     GLY G   191                                                      
REMARK 465     PRO G   192                                                      
REMARK 465     ILE G   193                                                      
REMARK 465     ARG G   194                                                      
REMARK 465     THR G   195                                                      
REMARK 465     LEU G   196                                                      
REMARK 465     SER G   197                                                      
REMARK 465     ALA G   198                                                      
REMARK 465     LYS G   199                                                      
REMARK 465     GLY G   200                                                      
REMARK 465     VAL G   201                                                      
REMARK 465     GLY G   202                                                      
REMARK 465     LYS G   256                                                      
REMARK 465     MET H   -25                                                      
REMARK 465     LYS H   -24                                                      
REMARK 465     HIS H   -23                                                      
REMARK 465     HIS H   -22                                                      
REMARK 465     HIS H   -21                                                      
REMARK 465     HIS H   -20                                                      
REMARK 465     HIS H   -19                                                      
REMARK 465     HIS H   -18                                                      
REMARK 465     PRO H   -17                                                      
REMARK 465     MET H   -16                                                      
REMARK 465     SER H   -15                                                      
REMARK 465     ASP H   -14                                                      
REMARK 465     TYR H   -13                                                      
REMARK 465     ASP H   -12                                                      
REMARK 465     ILE H   -11                                                      
REMARK 465     PRO H   -10                                                      
REMARK 465     THR H    -9                                                      
REMARK 465     THR H    -8                                                      
REMARK 465     GLU H    -7                                                      
REMARK 465     ASN H    -6                                                      
REMARK 465     LEU H    -5                                                      
REMARK 465     TYR H    -4                                                      
REMARK 465     PHE H    -3                                                      
REMARK 465     GLN H    -2                                                      
REMARK 465     GLY H    -1                                                      
REMARK 465     ALA H     0                                                      
REMARK 465     MET H     1                                                      
REMARK 465     VAL H     2                                                      
REMARK 465     ALA H    95                                                      
REMARK 465     PHE H    96                                                      
REMARK 465     ALA H    97                                                      
REMARK 465     ASN H    98                                                      
REMARK 465     MET H    99                                                      
REMARK 465     GLU H   100                                                      
REMARK 465     ASP H   101                                                      
REMARK 465     LEU H   102                                                      
REMARK 465     ARG H   103                                                      
REMARK 465     GLY H   104                                                      
REMARK 465     ARG H   105                                                      
REMARK 465     PHE H   106                                                      
REMARK 465     SER H   107                                                      
REMARK 465     LEU H   148                                                      
REMARK 465     GLY H   149                                                      
REMARK 465     GLY H   150                                                      
REMARK 465     GLU H   151                                                      
REMARK 465     PHE H   152                                                      
REMARK 465     ALA H   153                                                      
REMARK 465     VAL H   154                                                      
REMARK 465     GLN H   155                                                      
REMARK 465     ARG H   194                                                      
REMARK 465     THR H   195                                                      
REMARK 465     LEU H   196                                                      
REMARK 465     SER H   197                                                      
REMARK 465     ALA H   198                                                      
REMARK 465     LYS H   199                                                      
REMARK 465     GLY H   200                                                      
REMARK 465     VAL H   201                                                      
REMARK 465     GLY H   202                                                      
REMARK 465     GLY H   203                                                      
REMARK 465     PHE H   204                                                      
REMARK 465     ASN H   205                                                      
REMARK 465     LYS H   256                                                      
REMARK 465     MET I   -25                                                      
REMARK 465     LYS I   -24                                                      
REMARK 465     HIS I   -23                                                      
REMARK 465     HIS I   -22                                                      
REMARK 465     HIS I   -21                                                      
REMARK 465     HIS I   -20                                                      
REMARK 465     HIS I   -19                                                      
REMARK 465     HIS I   -18                                                      
REMARK 465     PRO I   -17                                                      
REMARK 465     MET I   -16                                                      
REMARK 465     SER I   -15                                                      
REMARK 465     ASP I   -14                                                      
REMARK 465     TYR I   -13                                                      
REMARK 465     ASP I   -12                                                      
REMARK 465     ILE I   -11                                                      
REMARK 465     PRO I   -10                                                      
REMARK 465     THR I    -9                                                      
REMARK 465     THR I    -8                                                      
REMARK 465     GLU I    -7                                                      
REMARK 465     ASN I    -6                                                      
REMARK 465     LEU I    -5                                                      
REMARK 465     TYR I    -4                                                      
REMARK 465     PHE I    -3                                                      
REMARK 465     GLN I    -2                                                      
REMARK 465     GLY I    -1                                                      
REMARK 465     ALA I     0                                                      
REMARK 465     MET I     1                                                      
REMARK 465     VAL I     2                                                      
REMARK 465     ALA I    95                                                      
REMARK 465     PHE I    96                                                      
REMARK 465     ALA I    97                                                      
REMARK 465     ASN I    98                                                      
REMARK 465     MET I    99                                                      
REMARK 465     GLU I   100                                                      
REMARK 465     ASP I   101                                                      
REMARK 465     LEU I   102                                                      
REMARK 465     ARG I   103                                                      
REMARK 465     GLY I   104                                                      
REMARK 465     ARG I   105                                                      
REMARK 465     PHE I   106                                                      
REMARK 465     SER I   107                                                      
REMARK 465     GLU I   108                                                      
REMARK 465     TYR I   147                                                      
REMARK 465     LEU I   148                                                      
REMARK 465     GLY I   149                                                      
REMARK 465     GLY I   150                                                      
REMARK 465     GLU I   151                                                      
REMARK 465     PHE I   152                                                      
REMARK 465     ALA I   153                                                      
REMARK 465     VAL I   154                                                      
REMARK 465     GLN I   155                                                      
REMARK 465     ASN I   156                                                      
REMARK 465     ALA I   190                                                      
REMARK 465     GLY I   191                                                      
REMARK 465     PRO I   192                                                      
REMARK 465     ILE I   193                                                      
REMARK 465     ARG I   194                                                      
REMARK 465     THR I   195                                                      
REMARK 465     LEU I   196                                                      
REMARK 465     SER I   197                                                      
REMARK 465     ALA I   198                                                      
REMARK 465     LYS I   199                                                      
REMARK 465     GLY I   200                                                      
REMARK 465     VAL I   201                                                      
REMARK 465     GLY I   202                                                      
REMARK 465     GLY I   203                                                      
REMARK 465     PHE I   204                                                      
REMARK 465     LYS I   256                                                      
REMARK 465     MET J   -25                                                      
REMARK 465     LYS J   -24                                                      
REMARK 465     HIS J   -23                                                      
REMARK 465     HIS J   -22                                                      
REMARK 465     HIS J   -21                                                      
REMARK 465     HIS J   -20                                                      
REMARK 465     HIS J   -19                                                      
REMARK 465     HIS J   -18                                                      
REMARK 465     PRO J   -17                                                      
REMARK 465     MET J   -16                                                      
REMARK 465     SER J   -15                                                      
REMARK 465     ASP J   -14                                                      
REMARK 465     TYR J   -13                                                      
REMARK 465     ASP J   -12                                                      
REMARK 465     ILE J   -11                                                      
REMARK 465     PRO J   -10                                                      
REMARK 465     THR J    -9                                                      
REMARK 465     THR J    -8                                                      
REMARK 465     GLU J    -7                                                      
REMARK 465     ASN J    -6                                                      
REMARK 465     LEU J    -5                                                      
REMARK 465     TYR J    -4                                                      
REMARK 465     PHE J    -3                                                      
REMARK 465     GLN J    -2                                                      
REMARK 465     GLY J    -1                                                      
REMARK 465     ALA J     0                                                      
REMARK 465     MET J     1                                                      
REMARK 465     VAL J     2                                                      
REMARK 465     ILE J    94                                                      
REMARK 465     ALA J    95                                                      
REMARK 465     PHE J    96                                                      
REMARK 465     ALA J    97                                                      
REMARK 465     ASN J    98                                                      
REMARK 465     MET J    99                                                      
REMARK 465     GLU J   100                                                      
REMARK 465     ASP J   101                                                      
REMARK 465     LEU J   102                                                      
REMARK 465     ARG J   103                                                      
REMARK 465     GLY J   104                                                      
REMARK 465     ARG J   105                                                      
REMARK 465     PHE J   106                                                      
REMARK 465     SER J   107                                                      
REMARK 465     GLU J   108                                                      
REMARK 465     TYR J   147                                                      
REMARK 465     LEU J   148                                                      
REMARK 465     GLY J   149                                                      
REMARK 465     GLY J   150                                                      
REMARK 465     GLU J   151                                                      
REMARK 465     PHE J   152                                                      
REMARK 465     ALA J   153                                                      
REMARK 465     VAL J   154                                                      
REMARK 465     GLN J   155                                                      
REMARK 465     ASN J   156                                                      
REMARK 465     TYR J   157                                                      
REMARK 465     ASN J   158                                                      
REMARK 465     GLY J   191                                                      
REMARK 465     PRO J   192                                                      
REMARK 465     ILE J   193                                                      
REMARK 465     ARG J   194                                                      
REMARK 465     THR J   195                                                      
REMARK 465     LEU J   196                                                      
REMARK 465     SER J   197                                                      
REMARK 465     ALA J   198                                                      
REMARK 465     LYS J   199                                                      
REMARK 465     GLY J   200                                                      
REMARK 465     VAL J   201                                                      
REMARK 465     GLY J   202                                                      
REMARK 465     GLY J   203                                                      
REMARK 465     PHE J   204                                                      
REMARK 465     ALA J   254                                                      
REMARK 465     ILE J   255                                                      
REMARK 465     LYS J   256                                                      
REMARK 465     MET K   -25                                                      
REMARK 465     LYS K   -24                                                      
REMARK 465     HIS K   -23                                                      
REMARK 465     HIS K   -22                                                      
REMARK 465     HIS K   -21                                                      
REMARK 465     HIS K   -20                                                      
REMARK 465     HIS K   -19                                                      
REMARK 465     HIS K   -18                                                      
REMARK 465     PRO K   -17                                                      
REMARK 465     MET K   -16                                                      
REMARK 465     SER K   -15                                                      
REMARK 465     ASP K   -14                                                      
REMARK 465     TYR K   -13                                                      
REMARK 465     ASP K   -12                                                      
REMARK 465     ILE K   -11                                                      
REMARK 465     PRO K   -10                                                      
REMARK 465     THR K    -9                                                      
REMARK 465     THR K    -8                                                      
REMARK 465     GLU K    -7                                                      
REMARK 465     ASN K    -6                                                      
REMARK 465     LEU K    -5                                                      
REMARK 465     TYR K    -4                                                      
REMARK 465     PHE K    -3                                                      
REMARK 465     GLN K    -2                                                      
REMARK 465     GLY K    -1                                                      
REMARK 465     ALA K     0                                                      
REMARK 465     MET K     1                                                      
REMARK 465     VAL K     2                                                      
REMARK 465     ALA K    95                                                      
REMARK 465     PHE K    96                                                      
REMARK 465     ALA K    97                                                      
REMARK 465     ASN K    98                                                      
REMARK 465     MET K    99                                                      
REMARK 465     GLU K   100                                                      
REMARK 465     ASP K   101                                                      
REMARK 465     LEU K   102                                                      
REMARK 465     ARG K   103                                                      
REMARK 465     GLY K   104                                                      
REMARK 465     ARG K   105                                                      
REMARK 465     PHE K   106                                                      
REMARK 465     SER K   107                                                      
REMARK 465     GLU K   108                                                      
REMARK 465     GLY K   149                                                      
REMARK 465     GLY K   150                                                      
REMARK 465     GLU K   151                                                      
REMARK 465     PHE K   152                                                      
REMARK 465     ALA K   153                                                      
REMARK 465     VAL K   154                                                      
REMARK 465     GLN K   155                                                      
REMARK 465     ASN K   156                                                      
REMARK 465     GLY K   191                                                      
REMARK 465     PRO K   192                                                      
REMARK 465     ILE K   193                                                      
REMARK 465     ARG K   194                                                      
REMARK 465     THR K   195                                                      
REMARK 465     LEU K   196                                                      
REMARK 465     SER K   197                                                      
REMARK 465     ALA K   198                                                      
REMARK 465     LYS K   199                                                      
REMARK 465     GLY K   200                                                      
REMARK 465     VAL K   201                                                      
REMARK 465     GLY K   202                                                      
REMARK 465     GLY K   203                                                      
REMARK 465     LYS K   256                                                      
REMARK 465     MET L   -25                                                      
REMARK 465     LYS L   -24                                                      
REMARK 465     HIS L   -23                                                      
REMARK 465     HIS L   -22                                                      
REMARK 465     HIS L   -21                                                      
REMARK 465     HIS L   -20                                                      
REMARK 465     HIS L   -19                                                      
REMARK 465     HIS L   -18                                                      
REMARK 465     PRO L   -17                                                      
REMARK 465     MET L   -16                                                      
REMARK 465     SER L   -15                                                      
REMARK 465     ASP L   -14                                                      
REMARK 465     TYR L   -13                                                      
REMARK 465     ASP L   -12                                                      
REMARK 465     ILE L   -11                                                      
REMARK 465     PRO L   -10                                                      
REMARK 465     THR L    -9                                                      
REMARK 465     THR L    -8                                                      
REMARK 465     GLU L    -7                                                      
REMARK 465     ASN L    -6                                                      
REMARK 465     LEU L    -5                                                      
REMARK 465     TYR L    -4                                                      
REMARK 465     PHE L    -3                                                      
REMARK 465     GLN L    -2                                                      
REMARK 465     GLY L    -1                                                      
REMARK 465     ALA L     0                                                      
REMARK 465     MET L     1                                                      
REMARK 465     VAL L     2                                                      
REMARK 465     ALA L    95                                                      
REMARK 465     PHE L    96                                                      
REMARK 465     ALA L    97                                                      
REMARK 465     ASN L    98                                                      
REMARK 465     MET L    99                                                      
REMARK 465     GLU L   100                                                      
REMARK 465     ASP L   101                                                      
REMARK 465     LEU L   102                                                      
REMARK 465     ARG L   103                                                      
REMARK 465     GLY L   104                                                      
REMARK 465     ARG L   105                                                      
REMARK 465     PHE L   106                                                      
REMARK 465     SER L   107                                                      
REMARK 465     TYR L   147                                                      
REMARK 465     LEU L   148                                                      
REMARK 465     GLY L   149                                                      
REMARK 465     GLY L   150                                                      
REMARK 465     GLU L   151                                                      
REMARK 465     PHE L   152                                                      
REMARK 465     ALA L   153                                                      
REMARK 465     VAL L   154                                                      
REMARK 465     GLN L   155                                                      
REMARK 465     ASN L   156                                                      
REMARK 465     TYR L   157                                                      
REMARK 465     ASN L   158                                                      
REMARK 465     ALA L   190                                                      
REMARK 465     GLY L   191                                                      
REMARK 465     PRO L   192                                                      
REMARK 465     ILE L   193                                                      
REMARK 465     ARG L   194                                                      
REMARK 465     THR L   195                                                      
REMARK 465     LEU L   196                                                      
REMARK 465     SER L   197                                                      
REMARK 465     ALA L   198                                                      
REMARK 465     LYS L   199                                                      
REMARK 465     GLY L   200                                                      
REMARK 465     VAL L   201                                                      
REMARK 465     GLY L   202                                                      
REMARK 465     GLY L   203                                                      
REMARK 465     PHE L   204                                                      
REMARK 465     ASN L   205                                                      
REMARK 465     THR L   206                                                      
REMARK 465     ILE L   207                                                      
REMARK 465     LEU L   208                                                      
REMARK 465     LYS L   209                                                      
REMARK 465     GLU L   210                                                      
REMARK 465     ILE L   211                                                      
REMARK 465     GLU L   212                                                      
REMARK 465     GLU L   213                                                      
REMARK 465     ARG L   214                                                      
REMARK 465     ALA L   215                                                      
REMARK 465     PRO L   216                                                      
REMARK 465     LEU L   217                                                      
REMARK 465     LYS L   218                                                      
REMARK 465     ARG L   219                                                      
REMARK 465     ASN L   220                                                      
REMARK 465     VAL L   221                                                      
REMARK 465     HIS L   253                                                      
REMARK 465     ALA L   254                                                      
REMARK 465     ILE L   255                                                      
REMARK 465     LYS L   256                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OD1  ASN G   170     OH   TYR H   157              2.14            
REMARK 500   OD1  ASP I   119     NH1  ARG J   111              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LEU C 176   CA  -  CB  -  CG  ANGL. DEV. = -18.2 DEGREES          
REMARK 500    ARG H  18   NE  -  CZ  -  NH1 ANGL. DEV. =   3.2 DEGREES          
REMARK 500    PRO H 192   C   -  N   -  CA  ANGL. DEV. =  10.7 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASN A   6        2.14     83.55                                   
REMARK 500    ALA A  15      -47.45   -132.64                                   
REMARK 500    ARG A  40      -67.33   -100.95                                   
REMARK 500    GLN A  54      -15.26    -49.13                                   
REMARK 500    ASN A  56       42.59    -82.53                                   
REMARK 500    ASN A  86      154.93    -48.22                                   
REMARK 500    ALA A  95       99.17    175.21                                   
REMARK 500    LYS A 133      -32.93    -39.41                                   
REMARK 500    ASN A 156      -67.63    -18.78                                   
REMARK 500    LEU A 217        0.00    -63.15                                   
REMARK 500    LYS A 218       18.37     58.28                                   
REMARK 500    VAL A 221     -163.61    -73.49                                   
REMARK 500    SER A 238       32.52    -95.31                                   
REMARK 500    ASP A 249       27.35   -149.84                                   
REMARK 500    ASN B  56       63.19   -102.85                                   
REMARK 500    ALA B  95     -151.47   -120.73                                   
REMARK 500    LYS B 133      -38.46    -37.64                                   
REMARK 500    PRO B 192      160.75    -37.88                                   
REMARK 500    THR B 206      -76.60    -98.35                                   
REMARK 500    GLU B 210      -33.92    -37.77                                   
REMARK 500    GLU B 213      -78.39    -73.14                                   
REMARK 500    LYS B 218      -18.38     86.59                                   
REMARK 500    ARG B 219     -154.99   -123.25                                   
REMARK 500    SER B 238       40.78    -95.30                                   
REMARK 500    VAL B 248       76.66   -104.53                                   
REMARK 500    ASP B 249       32.08   -143.48                                   
REMARK 500    ALA C  15      -40.79   -134.68                                   
REMARK 500    THR C 109      117.01     -2.34                                   
REMARK 500    ILE C 193      -79.14   -143.18                                   
REMARK 500    GLU C 213      -65.90    -91.42                                   
REMARK 500    LYS C 218      -45.04     93.70                                   
REMARK 500    VAL C 221     -159.88    -79.77                                   
REMARK 500    ASP C 222      163.53    178.93                                   
REMARK 500    SER C 238       40.68    -90.45                                   
REMARK 500    VAL C 248       79.69   -103.54                                   
REMARK 500    ASP C 249       28.70   -147.84                                   
REMARK 500    ARG D  40      -63.88    -97.36                                   
REMARK 500    LEU D  52       -8.56    -59.80                                   
REMARK 500    ASN D  56       59.16    -96.54                                   
REMARK 500    LYS D 133      -35.60    -39.38                                   
REMARK 500    SER D 238       34.10    -93.97                                   
REMARK 500    ASP D 249       26.80   -151.31                                   
REMARK 500    ARG E  40      -65.31   -100.54                                   
REMARK 500    GLU E 108       63.03   -167.40                                   
REMARK 500    THR E 109      -10.80     63.42                                   
REMARK 500    SER E 110      173.02    -47.44                                   
REMARK 500    LYS E 133      -37.13    -34.73                                   
REMARK 500    GLU E 213      -75.05    -96.99                                   
REMARK 500    VAL E 221      171.71    -43.14                                   
REMARK 500    SER E 238       35.32    -91.00                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     107 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CHIRAL CENTERS                                             
REMARK 500                                                                      
REMARK 500 UNEXPECTED CONFIGURATION OF THE FOLLOWING CHIRAL                     
REMARK 500 CENTER(S) USING IMPROPER CA--C--CB--N CHIRALITY                      
REMARK 500 FOR AMINO ACIDS AND C1'--O4'--N1(N9)--C2' FOR                        
REMARK 500 NUCLEIC ACIDS OR EQUIVALENT ANGLE                                    
REMARK 500 M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN                            
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE                   
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,6X,F5.1,6X,A1,10X,A1,3X,A16)       
REMARK 500                                                                      
REMARK 500  M RES CSSEQI    IMPROPER   EXPECTED   FOUND DETAILS                 
REMARK 500    TYR K 147        24.3      L          L   OUTSIDE RANGE           
REMARK 500    ASN K 158        24.3      L          L   OUTSIDE RANGE           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 525                                                                      
REMARK 525 SOLVENT                                                              
REMARK 525                                                                      
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT                    
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST                  
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT                 
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE                       
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;                             
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE                  
REMARK 525 NUMBER; I=INSERTION CODE):                                           
REMARK 525                                                                      
REMARK 525  M RES CSSEQI                                                        
REMARK 525    HOH D2006        DISTANCE =  5.08 ANGSTROMS                       
REMARK 525    HOH D2030        DISTANCE =  5.04 ANGSTROMS                       
REMARK 525    HOH L2013        DISTANCE =  7.38 ANGSTROMS                       
REMARK 525    HOH L2014        DISTANCE =  5.81 ANGSTROMS                       
REMARK 525    HOH L2015        DISTANCE =  5.68 ANGSTROMS                       
REMARK 525    HOH L2016        DISTANCE =  5.30 ANGSTROMS                       
REMARK 525    HOH L2017        DISTANCE =  8.39 ANGSTROMS                       
REMARK 525    HOH L2018        DISTANCE =  5.63 ANGSTROMS                       
REMARK 525    HOH L2020        DISTANCE =  5.28 ANGSTROMS                       
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 4ALI   RELATED DB: PDB                                   
REMARK 900  CRYSTAL STRUCTURE OF S. AUREUS FABI IN COMPLEX WITH                 
REMARK 900  NADP AND TRICLOSAN (P1)                                             
REMARK 900 RELATED ID: 4ALJ   RELATED DB: PDB                                   
REMARK 900  CRYSTAL STRUCTURE OF S. AUREUS FABI IN COMPLEX WITH                 
REMARK 900  NADP AND 5-CHLORO-2-PHENOXYPHENOL                                   
REMARK 900 RELATED ID: 4ALK   RELATED DB: PDB                                   
REMARK 900  CRYSTAL STRUCTURE OF S. AUREUS FABI IN COMPLEX WITH                 
REMARK 900  NADP AND 5-ETHYL-2-PHENOXYPHENOL                                    
REMARK 900 RELATED ID: 4ALL   RELATED DB: PDB                                   
REMARK 900  CRYSTAL STRUCTURE OF S. AUREUS FABI IN COMPLEX WITH                 
REMARK 900  NADP AND TRICLOSAN (P212121)                                        
REMARK 900 RELATED ID: 4ALM   RELATED DB: PDB                                   
REMARK 900  CRYSTAL STRUCTURE OF S. AUREUS FABI (P43212)                        
DBREF  4ALN A    1   256  UNP    Q7A6D8   Q7A6D8_STAAN     1    256             
DBREF  4ALN B    1   256  UNP    Q7A6D8   Q7A6D8_STAAN     1    256             
DBREF  4ALN C    1   256  UNP    Q7A6D8   Q7A6D8_STAAN     1    256             
DBREF  4ALN D    1   256  UNP    Q7A6D8   Q7A6D8_STAAN     1    256             
DBREF  4ALN E    1   256  UNP    Q7A6D8   Q7A6D8_STAAN     1    256             
DBREF  4ALN F    1   256  UNP    Q7A6D8   Q7A6D8_STAAN     1    256             
DBREF  4ALN G    1   256  UNP    Q7A6D8   Q7A6D8_STAAN     1    256             
DBREF  4ALN H    1   256  UNP    Q7A6D8   Q7A6D8_STAAN     1    256             
DBREF  4ALN I    1   256  UNP    Q7A6D8   Q7A6D8_STAAN     1    256             
DBREF  4ALN J    1   256  UNP    Q7A6D8   Q7A6D8_STAAN     1    256             
DBREF  4ALN K    1   256  UNP    Q7A6D8   Q7A6D8_STAAN     1    256             
DBREF  4ALN L    1   256  UNP    Q7A6D8   Q7A6D8_STAAN     1    256             
SEQADV 4ALN MET A  -25  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LYS A  -24  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS A  -23  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS A  -22  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS A  -21  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS A  -20  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS A  -19  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS A  -18  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO A  -17  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET A  -16  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN SER A  -15  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP A  -14  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR A  -13  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP A  -12  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ILE A  -11  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO A  -10  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR A   -9  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR A   -8  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLU A   -7  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASN A   -6  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LEU A   -5  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR A   -4  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PHE A   -3  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLN A   -2  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLY A   -1  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ALA A    0  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET B  -25  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LYS B  -24  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS B  -23  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS B  -22  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS B  -21  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS B  -20  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS B  -19  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS B  -18  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO B  -17  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET B  -16  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN SER B  -15  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP B  -14  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR B  -13  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP B  -12  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ILE B  -11  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO B  -10  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR B   -9  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR B   -8  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLU B   -7  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASN B   -6  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LEU B   -5  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR B   -4  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PHE B   -3  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLN B   -2  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLY B   -1  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ALA B    0  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET C  -25  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LYS C  -24  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS C  -23  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS C  -22  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS C  -21  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS C  -20  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS C  -19  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS C  -18  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO C  -17  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET C  -16  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN SER C  -15  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP C  -14  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR C  -13  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP C  -12  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ILE C  -11  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO C  -10  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR C   -9  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR C   -8  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLU C   -7  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASN C   -6  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LEU C   -5  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR C   -4  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PHE C   -3  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLN C   -2  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLY C   -1  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ALA C    0  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET D  -25  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LYS D  -24  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS D  -23  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS D  -22  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS D  -21  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS D  -20  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS D  -19  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS D  -18  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO D  -17  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET D  -16  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN SER D  -15  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP D  -14  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR D  -13  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP D  -12  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ILE D  -11  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO D  -10  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR D   -9  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR D   -8  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLU D   -7  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASN D   -6  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LEU D   -5  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR D   -4  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PHE D   -3  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLN D   -2  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLY D   -1  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ALA D    0  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET E  -25  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LYS E  -24  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS E  -23  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS E  -22  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS E  -21  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS E  -20  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS E  -19  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS E  -18  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO E  -17  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET E  -16  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN SER E  -15  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP E  -14  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR E  -13  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP E  -12  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ILE E  -11  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO E  -10  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR E   -9  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR E   -8  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLU E   -7  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASN E   -6  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LEU E   -5  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR E   -4  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PHE E   -3  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLN E   -2  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLY E   -1  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ALA E    0  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET F  -25  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LYS F  -24  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS F  -23  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS F  -22  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS F  -21  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS F  -20  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS F  -19  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS F  -18  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO F  -17  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET F  -16  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN SER F  -15  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP F  -14  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR F  -13  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP F  -12  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ILE F  -11  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO F  -10  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR F   -9  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR F   -8  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLU F   -7  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASN F   -6  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LEU F   -5  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR F   -4  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PHE F   -3  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLN F   -2  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLY F   -1  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ALA F    0  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET G  -25  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LYS G  -24  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS G  -23  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS G  -22  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS G  -21  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS G  -20  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS G  -19  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS G  -18  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO G  -17  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET G  -16  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN SER G  -15  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP G  -14  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR G  -13  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP G  -12  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ILE G  -11  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO G  -10  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR G   -9  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR G   -8  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLU G   -7  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASN G   -6  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LEU G   -5  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR G   -4  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PHE G   -3  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLN G   -2  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLY G   -1  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ALA G    0  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET H  -25  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LYS H  -24  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS H  -23  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS H  -22  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS H  -21  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS H  -20  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS H  -19  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS H  -18  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO H  -17  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET H  -16  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN SER H  -15  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP H  -14  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR H  -13  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP H  -12  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ILE H  -11  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO H  -10  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR H   -9  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR H   -8  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLU H   -7  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASN H   -6  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LEU H   -5  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR H   -4  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PHE H   -3  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLN H   -2  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLY H   -1  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ALA H    0  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET H    1  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET I  -25  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LYS I  -24  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS I  -23  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS I  -22  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS I  -21  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS I  -20  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS I  -19  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS I  -18  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO I  -17  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET I  -16  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN SER I  -15  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP I  -14  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR I  -13  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP I  -12  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ILE I  -11  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO I  -10  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR I   -9  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR I   -8  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLU I   -7  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASN I   -6  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LEU I   -5  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR I   -4  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PHE I   -3  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLN I   -2  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLY I   -1  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ALA I    0  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET J  -25  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LYS J  -24  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS J  -23  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS J  -22  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS J  -21  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS J  -20  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS J  -19  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS J  -18  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO J  -17  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET J  -16  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN SER J  -15  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP J  -14  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR J  -13  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP J  -12  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ILE J  -11  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO J  -10  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR J   -9  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR J   -8  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLU J   -7  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASN J   -6  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LEU J   -5  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR J   -4  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PHE J   -3  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLN J   -2  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLY J   -1  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ALA J    0  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET K  -25  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LYS K  -24  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS K  -23  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS K  -22  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS K  -21  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS K  -20  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS K  -19  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS K  -18  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO K  -17  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET K  -16  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN SER K  -15  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP K  -14  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR K  -13  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP K  -12  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ILE K  -11  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO K  -10  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR K   -9  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR K   -8  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLU K   -7  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASN K   -6  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LEU K   -5  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR K   -4  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PHE K   -3  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLN K   -2  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLY K   -1  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ALA K    0  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET L  -25  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LYS L  -24  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS L  -23  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS L  -22  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS L  -21  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS L  -20  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS L  -19  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN HIS L  -18  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO L  -17  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN MET L  -16  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN SER L  -15  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP L  -14  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR L  -13  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASP L  -12  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ILE L  -11  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PRO L  -10  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR L   -9  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN THR L   -8  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLU L   -7  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ASN L   -6  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN LEU L   -5  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN TYR L   -4  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN PHE L   -3  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLN L   -2  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN GLY L   -1  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN ALA L    0  UNP  Q7A6D8              EXPRESSION TAG                 
SEQADV 4ALN VAL A    2  UNP  Q7A6D8    LEU     2 ENGINEERED MUTATION            
SEQADV 4ALN VAL B    2  UNP  Q7A6D8    LEU     2 ENGINEERED MUTATION            
SEQADV 4ALN VAL C    2  UNP  Q7A6D8    LEU     2 ENGINEERED MUTATION            
SEQADV 4ALN VAL D    2  UNP  Q7A6D8    LEU     2 ENGINEERED MUTATION            
SEQADV 4ALN VAL E    2  UNP  Q7A6D8    LEU     2 ENGINEERED MUTATION            
SEQADV 4ALN VAL F    2  UNP  Q7A6D8    LEU     2 ENGINEERED MUTATION            
SEQADV 4ALN VAL G    2  UNP  Q7A6D8    LEU     2 ENGINEERED MUTATION            
SEQADV 4ALN VAL H    2  UNP  Q7A6D8    LEU     2 ENGINEERED MUTATION            
SEQADV 4ALN VAL I    2  UNP  Q7A6D8    LEU     2 ENGINEERED MUTATION            
SEQADV 4ALN VAL J    2  UNP  Q7A6D8    LEU     2 ENGINEERED MUTATION            
SEQADV 4ALN VAL K    2  UNP  Q7A6D8    LEU     2 ENGINEERED MUTATION            
SEQADV 4ALN VAL L    2  UNP  Q7A6D8    LEU     2 ENGINEERED MUTATION            
SEQRES   1 A  282  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 A  282  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 A  282  MET VAL ASN LEU GLU ASN LYS THR TYR VAL ILE MET GLY          
SEQRES   4 A  282  ILE ALA ASN LYS ARG SER ILE ALA PHE GLY VAL ALA LYS          
SEQRES   5 A  282  VAL LEU ASP GLN LEU GLY ALA LYS LEU VAL PHE THR TYR          
SEQRES   6 A  282  ARG LYS GLU ARG SER ARG LYS GLU LEU GLU LYS LEU LEU          
SEQRES   7 A  282  GLU GLN LEU ASN GLN PRO GLU ALA HIS LEU TYR GLN ILE          
SEQRES   8 A  282  ASP VAL GLN SER ASP GLU GLU VAL ILE ASN GLY PHE GLU          
SEQRES   9 A  282  GLN ILE GLY LYS ASP VAL GLY ASN ILE ASP GLY VAL TYR          
SEQRES  10 A  282  HIS SER ILE ALA PHE ALA ASN MET GLU ASP LEU ARG GLY          
SEQRES  11 A  282  ARG PHE SER GLU THR SER ARG GLU GLY PHE LEU LEU ALA          
SEQRES  12 A  282  GLN ASP ILE SER SER TYR SER LEU THR ILE VAL ALA HIS          
SEQRES  13 A  282  GLU ALA LYS LYS LEU MET PRO GLU GLY GLY SER ILE VAL          
SEQRES  14 A  282  ALA THR THR TYR LEU GLY GLY GLU PHE ALA VAL GLN ASN          
SEQRES  15 A  282  TYR ASN VAL MET GLY VAL ALA LYS ALA SER LEU GLU ALA          
SEQRES  16 A  282  ASN VAL LYS TYR LEU ALA LEU ASP LEU GLY PRO ASP ASN          
SEQRES  17 A  282  ILE ARG VAL ASN ALA ILE SER ALA GLY PRO ILE ARG THR          
SEQRES  18 A  282  LEU SER ALA LYS GLY VAL GLY GLY PHE ASN THR ILE LEU          
SEQRES  19 A  282  LYS GLU ILE GLU GLU ARG ALA PRO LEU LYS ARG ASN VAL          
SEQRES  20 A  282  ASP GLN VAL GLU VAL GLY LYS THR ALA ALA TYR LEU LEU          
SEQRES  21 A  282  SER ASP LEU SER SER GLY VAL THR GLY GLU ASN ILE HIS          
SEQRES  22 A  282  VAL ASP SER GLY PHE HIS ALA ILE LYS                          
SEQRES   1 B  282  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 B  282  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 B  282  MET VAL ASN LEU GLU ASN LYS THR TYR VAL ILE MET GLY          
SEQRES   4 B  282  ILE ALA ASN LYS ARG SER ILE ALA PHE GLY VAL ALA LYS          
SEQRES   5 B  282  VAL LEU ASP GLN LEU GLY ALA LYS LEU VAL PHE THR TYR          
SEQRES   6 B  282  ARG LYS GLU ARG SER ARG LYS GLU LEU GLU LYS LEU LEU          
SEQRES   7 B  282  GLU GLN LEU ASN GLN PRO GLU ALA HIS LEU TYR GLN ILE          
SEQRES   8 B  282  ASP VAL GLN SER ASP GLU GLU VAL ILE ASN GLY PHE GLU          
SEQRES   9 B  282  GLN ILE GLY LYS ASP VAL GLY ASN ILE ASP GLY VAL TYR          
SEQRES  10 B  282  HIS SER ILE ALA PHE ALA ASN MET GLU ASP LEU ARG GLY          
SEQRES  11 B  282  ARG PHE SER GLU THR SER ARG GLU GLY PHE LEU LEU ALA          
SEQRES  12 B  282  GLN ASP ILE SER SER TYR SER LEU THR ILE VAL ALA HIS          
SEQRES  13 B  282  GLU ALA LYS LYS LEU MET PRO GLU GLY GLY SER ILE VAL          
SEQRES  14 B  282  ALA THR THR TYR LEU GLY GLY GLU PHE ALA VAL GLN ASN          
SEQRES  15 B  282  TYR ASN VAL MET GLY VAL ALA LYS ALA SER LEU GLU ALA          
SEQRES  16 B  282  ASN VAL LYS TYR LEU ALA LEU ASP LEU GLY PRO ASP ASN          
SEQRES  17 B  282  ILE ARG VAL ASN ALA ILE SER ALA GLY PRO ILE ARG THR          
SEQRES  18 B  282  LEU SER ALA LYS GLY VAL GLY GLY PHE ASN THR ILE LEU          
SEQRES  19 B  282  LYS GLU ILE GLU GLU ARG ALA PRO LEU LYS ARG ASN VAL          
SEQRES  20 B  282  ASP GLN VAL GLU VAL GLY LYS THR ALA ALA TYR LEU LEU          
SEQRES  21 B  282  SER ASP LEU SER SER GLY VAL THR GLY GLU ASN ILE HIS          
SEQRES  22 B  282  VAL ASP SER GLY PHE HIS ALA ILE LYS                          
SEQRES   1 C  282  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 C  282  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 C  282  MET VAL ASN LEU GLU ASN LYS THR TYR VAL ILE MET GLY          
SEQRES   4 C  282  ILE ALA ASN LYS ARG SER ILE ALA PHE GLY VAL ALA LYS          
SEQRES   5 C  282  VAL LEU ASP GLN LEU GLY ALA LYS LEU VAL PHE THR TYR          
SEQRES   6 C  282  ARG LYS GLU ARG SER ARG LYS GLU LEU GLU LYS LEU LEU          
SEQRES   7 C  282  GLU GLN LEU ASN GLN PRO GLU ALA HIS LEU TYR GLN ILE          
SEQRES   8 C  282  ASP VAL GLN SER ASP GLU GLU VAL ILE ASN GLY PHE GLU          
SEQRES   9 C  282  GLN ILE GLY LYS ASP VAL GLY ASN ILE ASP GLY VAL TYR          
SEQRES  10 C  282  HIS SER ILE ALA PHE ALA ASN MET GLU ASP LEU ARG GLY          
SEQRES  11 C  282  ARG PHE SER GLU THR SER ARG GLU GLY PHE LEU LEU ALA          
SEQRES  12 C  282  GLN ASP ILE SER SER TYR SER LEU THR ILE VAL ALA HIS          
SEQRES  13 C  282  GLU ALA LYS LYS LEU MET PRO GLU GLY GLY SER ILE VAL          
SEQRES  14 C  282  ALA THR THR TYR LEU GLY GLY GLU PHE ALA VAL GLN ASN          
SEQRES  15 C  282  TYR ASN VAL MET GLY VAL ALA LYS ALA SER LEU GLU ALA          
SEQRES  16 C  282  ASN VAL LYS TYR LEU ALA LEU ASP LEU GLY PRO ASP ASN          
SEQRES  17 C  282  ILE ARG VAL ASN ALA ILE SER ALA GLY PRO ILE ARG THR          
SEQRES  18 C  282  LEU SER ALA LYS GLY VAL GLY GLY PHE ASN THR ILE LEU          
SEQRES  19 C  282  LYS GLU ILE GLU GLU ARG ALA PRO LEU LYS ARG ASN VAL          
SEQRES  20 C  282  ASP GLN VAL GLU VAL GLY LYS THR ALA ALA TYR LEU LEU          
SEQRES  21 C  282  SER ASP LEU SER SER GLY VAL THR GLY GLU ASN ILE HIS          
SEQRES  22 C  282  VAL ASP SER GLY PHE HIS ALA ILE LYS                          
SEQRES   1 D  282  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 D  282  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 D  282  MET VAL ASN LEU GLU ASN LYS THR TYR VAL ILE MET GLY          
SEQRES   4 D  282  ILE ALA ASN LYS ARG SER ILE ALA PHE GLY VAL ALA LYS          
SEQRES   5 D  282  VAL LEU ASP GLN LEU GLY ALA LYS LEU VAL PHE THR TYR          
SEQRES   6 D  282  ARG LYS GLU ARG SER ARG LYS GLU LEU GLU LYS LEU LEU          
SEQRES   7 D  282  GLU GLN LEU ASN GLN PRO GLU ALA HIS LEU TYR GLN ILE          
SEQRES   8 D  282  ASP VAL GLN SER ASP GLU GLU VAL ILE ASN GLY PHE GLU          
SEQRES   9 D  282  GLN ILE GLY LYS ASP VAL GLY ASN ILE ASP GLY VAL TYR          
SEQRES  10 D  282  HIS SER ILE ALA PHE ALA ASN MET GLU ASP LEU ARG GLY          
SEQRES  11 D  282  ARG PHE SER GLU THR SER ARG GLU GLY PHE LEU LEU ALA          
SEQRES  12 D  282  GLN ASP ILE SER SER TYR SER LEU THR ILE VAL ALA HIS          
SEQRES  13 D  282  GLU ALA LYS LYS LEU MET PRO GLU GLY GLY SER ILE VAL          
SEQRES  14 D  282  ALA THR THR TYR LEU GLY GLY GLU PHE ALA VAL GLN ASN          
SEQRES  15 D  282  TYR ASN VAL MET GLY VAL ALA LYS ALA SER LEU GLU ALA          
SEQRES  16 D  282  ASN VAL LYS TYR LEU ALA LEU ASP LEU GLY PRO ASP ASN          
SEQRES  17 D  282  ILE ARG VAL ASN ALA ILE SER ALA GLY PRO ILE ARG THR          
SEQRES  18 D  282  LEU SER ALA LYS GLY VAL GLY GLY PHE ASN THR ILE LEU          
SEQRES  19 D  282  LYS GLU ILE GLU GLU ARG ALA PRO LEU LYS ARG ASN VAL          
SEQRES  20 D  282  ASP GLN VAL GLU VAL GLY LYS THR ALA ALA TYR LEU LEU          
SEQRES  21 D  282  SER ASP LEU SER SER GLY VAL THR GLY GLU ASN ILE HIS          
SEQRES  22 D  282  VAL ASP SER GLY PHE HIS ALA ILE LYS                          
SEQRES   1 E  282  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 E  282  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 E  282  MET VAL ASN LEU GLU ASN LYS THR TYR VAL ILE MET GLY          
SEQRES   4 E  282  ILE ALA ASN LYS ARG SER ILE ALA PHE GLY VAL ALA LYS          
SEQRES   5 E  282  VAL LEU ASP GLN LEU GLY ALA LYS LEU VAL PHE THR TYR          
SEQRES   6 E  282  ARG LYS GLU ARG SER ARG LYS GLU LEU GLU LYS LEU LEU          
SEQRES   7 E  282  GLU GLN LEU ASN GLN PRO GLU ALA HIS LEU TYR GLN ILE          
SEQRES   8 E  282  ASP VAL GLN SER ASP GLU GLU VAL ILE ASN GLY PHE GLU          
SEQRES   9 E  282  GLN ILE GLY LYS ASP VAL GLY ASN ILE ASP GLY VAL TYR          
SEQRES  10 E  282  HIS SER ILE ALA PHE ALA ASN MET GLU ASP LEU ARG GLY          
SEQRES  11 E  282  ARG PHE SER GLU THR SER ARG GLU GLY PHE LEU LEU ALA          
SEQRES  12 E  282  GLN ASP ILE SER SER TYR SER LEU THR ILE VAL ALA HIS          
SEQRES  13 E  282  GLU ALA LYS LYS LEU MET PRO GLU GLY GLY SER ILE VAL          
SEQRES  14 E  282  ALA THR THR TYR LEU GLY GLY GLU PHE ALA VAL GLN ASN          
SEQRES  15 E  282  TYR ASN VAL MET GLY VAL ALA LYS ALA SER LEU GLU ALA          
SEQRES  16 E  282  ASN VAL LYS TYR LEU ALA LEU ASP LEU GLY PRO ASP ASN          
SEQRES  17 E  282  ILE ARG VAL ASN ALA ILE SER ALA GLY PRO ILE ARG THR          
SEQRES  18 E  282  LEU SER ALA LYS GLY VAL GLY GLY PHE ASN THR ILE LEU          
SEQRES  19 E  282  LYS GLU ILE GLU GLU ARG ALA PRO LEU LYS ARG ASN VAL          
SEQRES  20 E  282  ASP GLN VAL GLU VAL GLY LYS THR ALA ALA TYR LEU LEU          
SEQRES  21 E  282  SER ASP LEU SER SER GLY VAL THR GLY GLU ASN ILE HIS          
SEQRES  22 E  282  VAL ASP SER GLY PHE HIS ALA ILE LYS                          
SEQRES   1 F  282  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 F  282  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 F  282  MET VAL ASN LEU GLU ASN LYS THR TYR VAL ILE MET GLY          
SEQRES   4 F  282  ILE ALA ASN LYS ARG SER ILE ALA PHE GLY VAL ALA LYS          
SEQRES   5 F  282  VAL LEU ASP GLN LEU GLY ALA LYS LEU VAL PHE THR TYR          
SEQRES   6 F  282  ARG LYS GLU ARG SER ARG LYS GLU LEU GLU LYS LEU LEU          
SEQRES   7 F  282  GLU GLN LEU ASN GLN PRO GLU ALA HIS LEU TYR GLN ILE          
SEQRES   8 F  282  ASP VAL GLN SER ASP GLU GLU VAL ILE ASN GLY PHE GLU          
SEQRES   9 F  282  GLN ILE GLY LYS ASP VAL GLY ASN ILE ASP GLY VAL TYR          
SEQRES  10 F  282  HIS SER ILE ALA PHE ALA ASN MET GLU ASP LEU ARG GLY          
SEQRES  11 F  282  ARG PHE SER GLU THR SER ARG GLU GLY PHE LEU LEU ALA          
SEQRES  12 F  282  GLN ASP ILE SER SER TYR SER LEU THR ILE VAL ALA HIS          
SEQRES  13 F  282  GLU ALA LYS LYS LEU MET PRO GLU GLY GLY SER ILE VAL          
SEQRES  14 F  282  ALA THR THR TYR LEU GLY GLY GLU PHE ALA VAL GLN ASN          
SEQRES  15 F  282  TYR ASN VAL MET GLY VAL ALA LYS ALA SER LEU GLU ALA          
SEQRES  16 F  282  ASN VAL LYS TYR LEU ALA LEU ASP LEU GLY PRO ASP ASN          
SEQRES  17 F  282  ILE ARG VAL ASN ALA ILE SER ALA GLY PRO ILE ARG THR          
SEQRES  18 F  282  LEU SER ALA LYS GLY VAL GLY GLY PHE ASN THR ILE LEU          
SEQRES  19 F  282  LYS GLU ILE GLU GLU ARG ALA PRO LEU LYS ARG ASN VAL          
SEQRES  20 F  282  ASP GLN VAL GLU VAL GLY LYS THR ALA ALA TYR LEU LEU          
SEQRES  21 F  282  SER ASP LEU SER SER GLY VAL THR GLY GLU ASN ILE HIS          
SEQRES  22 F  282  VAL ASP SER GLY PHE HIS ALA ILE LYS                          
SEQRES   1 G  282  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 G  282  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 G  282  MET VAL ASN LEU GLU ASN LYS THR TYR VAL ILE MET GLY          
SEQRES   4 G  282  ILE ALA ASN LYS ARG SER ILE ALA PHE GLY VAL ALA LYS          
SEQRES   5 G  282  VAL LEU ASP GLN LEU GLY ALA LYS LEU VAL PHE THR TYR          
SEQRES   6 G  282  ARG LYS GLU ARG SER ARG LYS GLU LEU GLU LYS LEU LEU          
SEQRES   7 G  282  GLU GLN LEU ASN GLN PRO GLU ALA HIS LEU TYR GLN ILE          
SEQRES   8 G  282  ASP VAL GLN SER ASP GLU GLU VAL ILE ASN GLY PHE GLU          
SEQRES   9 G  282  GLN ILE GLY LYS ASP VAL GLY ASN ILE ASP GLY VAL TYR          
SEQRES  10 G  282  HIS SER ILE ALA PHE ALA ASN MET GLU ASP LEU ARG GLY          
SEQRES  11 G  282  ARG PHE SER GLU THR SER ARG GLU GLY PHE LEU LEU ALA          
SEQRES  12 G  282  GLN ASP ILE SER SER TYR SER LEU THR ILE VAL ALA HIS          
SEQRES  13 G  282  GLU ALA LYS LYS LEU MET PRO GLU GLY GLY SER ILE VAL          
SEQRES  14 G  282  ALA THR THR TYR LEU GLY GLY GLU PHE ALA VAL GLN ASN          
SEQRES  15 G  282  TYR ASN VAL MET GLY VAL ALA LYS ALA SER LEU GLU ALA          
SEQRES  16 G  282  ASN VAL LYS TYR LEU ALA LEU ASP LEU GLY PRO ASP ASN          
SEQRES  17 G  282  ILE ARG VAL ASN ALA ILE SER ALA GLY PRO ILE ARG THR          
SEQRES  18 G  282  LEU SER ALA LYS GLY VAL GLY GLY PHE ASN THR ILE LEU          
SEQRES  19 G  282  LYS GLU ILE GLU GLU ARG ALA PRO LEU LYS ARG ASN VAL          
SEQRES  20 G  282  ASP GLN VAL GLU VAL GLY LYS THR ALA ALA TYR LEU LEU          
SEQRES  21 G  282  SER ASP LEU SER SER GLY VAL THR GLY GLU ASN ILE HIS          
SEQRES  22 G  282  VAL ASP SER GLY PHE HIS ALA ILE LYS                          
SEQRES   1 H  282  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 H  282  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 H  282  MET VAL ASN LEU GLU ASN LYS THR TYR VAL ILE MET GLY          
SEQRES   4 H  282  ILE ALA ASN LYS ARG SER ILE ALA PHE GLY VAL ALA LYS          
SEQRES   5 H  282  VAL LEU ASP GLN LEU GLY ALA LYS LEU VAL PHE THR TYR          
SEQRES   6 H  282  ARG LYS GLU ARG SER ARG LYS GLU LEU GLU LYS LEU LEU          
SEQRES   7 H  282  GLU GLN LEU ASN GLN PRO GLU ALA HIS LEU TYR GLN ILE          
SEQRES   8 H  282  ASP VAL GLN SER ASP GLU GLU VAL ILE ASN GLY PHE GLU          
SEQRES   9 H  282  GLN ILE GLY LYS ASP VAL GLY ASN ILE ASP GLY VAL TYR          
SEQRES  10 H  282  HIS SER ILE ALA PHE ALA ASN MET GLU ASP LEU ARG GLY          
SEQRES  11 H  282  ARG PHE SER GLU THR SER ARG GLU GLY PHE LEU LEU ALA          
SEQRES  12 H  282  GLN ASP ILE SER SER TYR SER LEU THR ILE VAL ALA HIS          
SEQRES  13 H  282  GLU ALA LYS LYS LEU MET PRO GLU GLY GLY SER ILE VAL          
SEQRES  14 H  282  ALA THR THR TYR LEU GLY GLY GLU PHE ALA VAL GLN ASN          
SEQRES  15 H  282  TYR ASN VAL MET GLY VAL ALA LYS ALA SER LEU GLU ALA          
SEQRES  16 H  282  ASN VAL LYS TYR LEU ALA LEU ASP LEU GLY PRO ASP ASN          
SEQRES  17 H  282  ILE ARG VAL ASN ALA ILE SER ALA GLY PRO ILE ARG THR          
SEQRES  18 H  282  LEU SER ALA LYS GLY VAL GLY GLY PHE ASN THR ILE LEU          
SEQRES  19 H  282  LYS GLU ILE GLU GLU ARG ALA PRO LEU LYS ARG ASN VAL          
SEQRES  20 H  282  ASP GLN VAL GLU VAL GLY LYS THR ALA ALA TYR LEU LEU          
SEQRES  21 H  282  SER ASP LEU SER SER GLY VAL THR GLY GLU ASN ILE HIS          
SEQRES  22 H  282  VAL ASP SER GLY PHE HIS ALA ILE LYS                          
SEQRES   1 I  282  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 I  282  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 I  282  MET VAL ASN LEU GLU ASN LYS THR TYR VAL ILE MET GLY          
SEQRES   4 I  282  ILE ALA ASN LYS ARG SER ILE ALA PHE GLY VAL ALA LYS          
SEQRES   5 I  282  VAL LEU ASP GLN LEU GLY ALA LYS LEU VAL PHE THR TYR          
SEQRES   6 I  282  ARG LYS GLU ARG SER ARG LYS GLU LEU GLU LYS LEU LEU          
SEQRES   7 I  282  GLU GLN LEU ASN GLN PRO GLU ALA HIS LEU TYR GLN ILE          
SEQRES   8 I  282  ASP VAL GLN SER ASP GLU GLU VAL ILE ASN GLY PHE GLU          
SEQRES   9 I  282  GLN ILE GLY LYS ASP VAL GLY ASN ILE ASP GLY VAL TYR          
SEQRES  10 I  282  HIS SER ILE ALA PHE ALA ASN MET GLU ASP LEU ARG GLY          
SEQRES  11 I  282  ARG PHE SER GLU THR SER ARG GLU GLY PHE LEU LEU ALA          
SEQRES  12 I  282  GLN ASP ILE SER SER TYR SER LEU THR ILE VAL ALA HIS          
SEQRES  13 I  282  GLU ALA LYS LYS LEU MET PRO GLU GLY GLY SER ILE VAL          
SEQRES  14 I  282  ALA THR THR TYR LEU GLY GLY GLU PHE ALA VAL GLN ASN          
SEQRES  15 I  282  TYR ASN VAL MET GLY VAL ALA LYS ALA SER LEU GLU ALA          
SEQRES  16 I  282  ASN VAL LYS TYR LEU ALA LEU ASP LEU GLY PRO ASP ASN          
SEQRES  17 I  282  ILE ARG VAL ASN ALA ILE SER ALA GLY PRO ILE ARG THR          
SEQRES  18 I  282  LEU SER ALA LYS GLY VAL GLY GLY PHE ASN THR ILE LEU          
SEQRES  19 I  282  LYS GLU ILE GLU GLU ARG ALA PRO LEU LYS ARG ASN VAL          
SEQRES  20 I  282  ASP GLN VAL GLU VAL GLY LYS THR ALA ALA TYR LEU LEU          
SEQRES  21 I  282  SER ASP LEU SER SER GLY VAL THR GLY GLU ASN ILE HIS          
SEQRES  22 I  282  VAL ASP SER GLY PHE HIS ALA ILE LYS                          
SEQRES   1 J  282  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 J  282  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 J  282  MET VAL ASN LEU GLU ASN LYS THR TYR VAL ILE MET GLY          
SEQRES   4 J  282  ILE ALA ASN LYS ARG SER ILE ALA PHE GLY VAL ALA LYS          
SEQRES   5 J  282  VAL LEU ASP GLN LEU GLY ALA LYS LEU VAL PHE THR TYR          
SEQRES   6 J  282  ARG LYS GLU ARG SER ARG LYS GLU LEU GLU LYS LEU LEU          
SEQRES   7 J  282  GLU GLN LEU ASN GLN PRO GLU ALA HIS LEU TYR GLN ILE          
SEQRES   8 J  282  ASP VAL GLN SER ASP GLU GLU VAL ILE ASN GLY PHE GLU          
SEQRES   9 J  282  GLN ILE GLY LYS ASP VAL GLY ASN ILE ASP GLY VAL TYR          
SEQRES  10 J  282  HIS SER ILE ALA PHE ALA ASN MET GLU ASP LEU ARG GLY          
SEQRES  11 J  282  ARG PHE SER GLU THR SER ARG GLU GLY PHE LEU LEU ALA          
SEQRES  12 J  282  GLN ASP ILE SER SER TYR SER LEU THR ILE VAL ALA HIS          
SEQRES  13 J  282  GLU ALA LYS LYS LEU MET PRO GLU GLY GLY SER ILE VAL          
SEQRES  14 J  282  ALA THR THR TYR LEU GLY GLY GLU PHE ALA VAL GLN ASN          
SEQRES  15 J  282  TYR ASN VAL MET GLY VAL ALA LYS ALA SER LEU GLU ALA          
SEQRES  16 J  282  ASN VAL LYS TYR LEU ALA LEU ASP LEU GLY PRO ASP ASN          
SEQRES  17 J  282  ILE ARG VAL ASN ALA ILE SER ALA GLY PRO ILE ARG THR          
SEQRES  18 J  282  LEU SER ALA LYS GLY VAL GLY GLY PHE ASN THR ILE LEU          
SEQRES  19 J  282  LYS GLU ILE GLU GLU ARG ALA PRO LEU LYS ARG ASN VAL          
SEQRES  20 J  282  ASP GLN VAL GLU VAL GLY LYS THR ALA ALA TYR LEU LEU          
SEQRES  21 J  282  SER ASP LEU SER SER GLY VAL THR GLY GLU ASN ILE HIS          
SEQRES  22 J  282  VAL ASP SER GLY PHE HIS ALA ILE LYS                          
SEQRES   1 K  282  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 K  282  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 K  282  MET VAL ASN LEU GLU ASN LYS THR TYR VAL ILE MET GLY          
SEQRES   4 K  282  ILE ALA ASN LYS ARG SER ILE ALA PHE GLY VAL ALA LYS          
SEQRES   5 K  282  VAL LEU ASP GLN LEU GLY ALA LYS LEU VAL PHE THR TYR          
SEQRES   6 K  282  ARG LYS GLU ARG SER ARG LYS GLU LEU GLU LYS LEU LEU          
SEQRES   7 K  282  GLU GLN LEU ASN GLN PRO GLU ALA HIS LEU TYR GLN ILE          
SEQRES   8 K  282  ASP VAL GLN SER ASP GLU GLU VAL ILE ASN GLY PHE GLU          
SEQRES   9 K  282  GLN ILE GLY LYS ASP VAL GLY ASN ILE ASP GLY VAL TYR          
SEQRES  10 K  282  HIS SER ILE ALA PHE ALA ASN MET GLU ASP LEU ARG GLY          
SEQRES  11 K  282  ARG PHE SER GLU THR SER ARG GLU GLY PHE LEU LEU ALA          
SEQRES  12 K  282  GLN ASP ILE SER SER TYR SER LEU THR ILE VAL ALA HIS          
SEQRES  13 K  282  GLU ALA LYS LYS LEU MET PRO GLU GLY GLY SER ILE VAL          
SEQRES  14 K  282  ALA THR THR TYR LEU GLY GLY GLU PHE ALA VAL GLN ASN          
SEQRES  15 K  282  TYR ASN VAL MET GLY VAL ALA LYS ALA SER LEU GLU ALA          
SEQRES  16 K  282  ASN VAL LYS TYR LEU ALA LEU ASP LEU GLY PRO ASP ASN          
SEQRES  17 K  282  ILE ARG VAL ASN ALA ILE SER ALA GLY PRO ILE ARG THR          
SEQRES  18 K  282  LEU SER ALA LYS GLY VAL GLY GLY PHE ASN THR ILE LEU          
SEQRES  19 K  282  LYS GLU ILE GLU GLU ARG ALA PRO LEU LYS ARG ASN VAL          
SEQRES  20 K  282  ASP GLN VAL GLU VAL GLY LYS THR ALA ALA TYR LEU LEU          
SEQRES  21 K  282  SER ASP LEU SER SER GLY VAL THR GLY GLU ASN ILE HIS          
SEQRES  22 K  282  VAL ASP SER GLY PHE HIS ALA ILE LYS                          
SEQRES   1 L  282  MET LYS HIS HIS HIS HIS HIS HIS PRO MET SER ASP TYR          
SEQRES   2 L  282  ASP ILE PRO THR THR GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 L  282  MET VAL ASN LEU GLU ASN LYS THR TYR VAL ILE MET GLY          
SEQRES   4 L  282  ILE ALA ASN LYS ARG SER ILE ALA PHE GLY VAL ALA LYS          
SEQRES   5 L  282  VAL LEU ASP GLN LEU GLY ALA LYS LEU VAL PHE THR TYR          
SEQRES   6 L  282  ARG LYS GLU ARG SER ARG LYS GLU LEU GLU LYS LEU LEU          
SEQRES   7 L  282  GLU GLN LEU ASN GLN PRO GLU ALA HIS LEU TYR GLN ILE          
SEQRES   8 L  282  ASP VAL GLN SER ASP GLU GLU VAL ILE ASN GLY PHE GLU          
SEQRES   9 L  282  GLN ILE GLY LYS ASP VAL GLY ASN ILE ASP GLY VAL TYR          
SEQRES  10 L  282  HIS SER ILE ALA PHE ALA ASN MET GLU ASP LEU ARG GLY          
SEQRES  11 L  282  ARG PHE SER GLU THR SER ARG GLU GLY PHE LEU LEU ALA          
SEQRES  12 L  282  GLN ASP ILE SER SER TYR SER LEU THR ILE VAL ALA HIS          
SEQRES  13 L  282  GLU ALA LYS LYS LEU MET PRO GLU GLY GLY SER ILE VAL          
SEQRES  14 L  282  ALA THR THR TYR LEU GLY GLY GLU PHE ALA VAL GLN ASN          
SEQRES  15 L  282  TYR ASN VAL MET GLY VAL ALA LYS ALA SER LEU GLU ALA          
SEQRES  16 L  282  ASN VAL LYS TYR LEU ALA LEU ASP LEU GLY PRO ASP ASN          
SEQRES  17 L  282  ILE ARG VAL ASN ALA ILE SER ALA GLY PRO ILE ARG THR          
SEQRES  18 L  282  LEU SER ALA LYS GLY VAL GLY GLY PHE ASN THR ILE LEU          
SEQRES  19 L  282  LYS GLU ILE GLU GLU ARG ALA PRO LEU LYS ARG ASN VAL          
SEQRES  20 L  282  ASP GLN VAL GLU VAL GLY LYS THR ALA ALA TYR LEU LEU          
SEQRES  21 L  282  SER ASP LEU SER SER GLY VAL THR GLY GLU ASN ILE HIS          
SEQRES  22 L  282  VAL ASP SER GLY PHE HIS ALA ILE LYS                          
FORMUL  13  HOH   *250(H2 O)                                                    
HELIX    1   1 SER A   19  LEU A   31  1                                  13    
HELIX    2   2 LYS A   41  ARG A   43  5                                   3    
HELIX    3   3 SER A   44  GLN A   54  1                                  11    
HELIX    4   4 SER A   69  GLY A   85  1                                  17    
HELIX    5   5 SER A  110  SER A  122  1                                  13    
HELIX    6   6 SER A  122  LYS A  133  1                                  12    
HELIX    7   7 LYS A  134  MET A  136  5                                   3    
HELIX    8   8 ASN A  158  GLY A  179  1                                  22    
HELIX    9   9 ASN A  205  ALA A  215  1                                  11    
HELIX   10  10 ASP A  222  SER A  235  1                                  14    
HELIX   11  11 ASP A  236  SER A  239  5                                   4    
HELIX   12  12 GLY A  251  ILE A  255  5                                   5    
HELIX   13  13 SER B   19  LEU B   31  1                                  13    
HELIX   14  14 LYS B   41  ARG B   43  5                                   3    
HELIX   15  15 SER B   44  LEU B   55  1                                  12    
HELIX   16  16 SER B   69  GLY B   85  1                                  17    
HELIX   17  17 SER B  110  SER B  122  1                                  13    
HELIX   18  18 SER B  122  LYS B  133  1                                  12    
HELIX   19  19 LYS B  134  MET B  136  5                                   3    
HELIX   20  20 ASN B  158  GLY B  179  1                                  22    
HELIX   21  21 THR B  206  ALA B  215  1                                  10    
HELIX   22  22 ASP B  222  SER B  235  1                                  14    
HELIX   23  23 ASP B  236  SER B  239  5                                   4    
HELIX   24  24 GLY B  251  ILE B  255  5                                   5    
HELIX   25  25 SER C   19  LEU C   31  1                                  13    
HELIX   26  26 LYS C   41  LEU C   55  1                                  15    
HELIX   27  27 SER C   69  GLY C   85  1                                  17    
HELIX   28  28 SER C  110  SER C  122  1                                  13    
HELIX   29  29 SER C  122  LYS C  133  1                                  12    
HELIX   30  30 LYS C  134  MET C  136  5                                   3    
HELIX   31  31 ASN C  158  LEU C  178  1                                  21    
HELIX   32  32 GLY C  179  ASP C  181  5                                   3    
HELIX   33  33 GLY C  203  ARG C  214  1                                  12    
HELIX   34  34 ASP C  222  SER C  235  1                                  14    
HELIX   35  35 ASP C  236  SER C  239  5                                   4    
HELIX   36  36 GLY C  251  ILE C  255  5                                   5    
HELIX   37  37 SER D   19  LEU D   31  1                                  13    
HELIX   38  38 GLU D   42  LEU D   55  1                                  14    
HELIX   39  39 SER D   69  GLY D   85  1                                  17    
HELIX   40  40 SER D  110  SER D  122  1                                  13    
HELIX   41  41 SER D  122  LYS D  133  1                                  12    
HELIX   42  42 LYS D  134  MET D  136  5                                   3    
HELIX   43  43 ASN D  158  GLY D  179  1                                  22    
HELIX   44  44 ASP D  222  SER D  235  1                                  14    
HELIX   45  45 ASP D  236  SER D  239  5                                   4    
HELIX   46  46 SER E   19  LEU E   31  1                                  13    
HELIX   47  47 LYS E   41  ARG E   43  5                                   3    
HELIX   48  48 SER E   44  LEU E   55  1                                  12    
HELIX   49  49 SER E   69  GLY E   85  1                                  17    
HELIX   50  50 SER E  110  SER E  122  1                                  13    
HELIX   51  51 SER E  122  LYS E  133  1                                  12    
HELIX   52  52 LYS E  134  MET E  136  5                                   3    
HELIX   53  53 ASN E  158  GLY E  179  1                                  22    
HELIX   54  54 GLY E  203  ALA E  215  1                                  13    
HELIX   55  55 ASP E  222  SER E  235  1                                  14    
HELIX   56  56 ASP E  236  SER E  239  5                                   4    
HELIX   57  57 GLY E  251  ILE E  255  5                                   5    
HELIX   58  58 SER F   19  LEU F   31  1                                  13    
HELIX   59  59 GLU F   42  LEU F   52  1                                  11    
HELIX   60  60 SER F   69  GLY F   85  1                                  17    
HELIX   61  61 SER F  110  SER F  122  1                                  13    
HELIX   62  62 SER F  122  LYS F  133  1                                  12    
HELIX   63  63 LYS F  134  MET F  136  5                                   3    
HELIX   64  64 ASN F  158  GLY F  179  1                                  22    
HELIX   65  65 ASP F  222  SER F  235  1                                  14    
HELIX   66  66 ASP F  236  SER F  239  5                                   4    
HELIX   67  67 GLY F  251  ILE F  255  5                                   5    
HELIX   68  68 SER G   19  LEU G   31  1                                  13    
HELIX   69  69 LYS G   41  ARG G   43  5                                   3    
HELIX   70  70 SER G   44  LEU G   55  1                                  12    
HELIX   71  71 SER G   69  GLY G   85  1                                  17    
HELIX   72  72 SER G  110  SER G  122  1                                  13    
HELIX   73  73 SER G  122  LYS G  133  1                                  12    
HELIX   74  74 LYS G  134  MET G  136  5                                   3    
HELIX   75  75 ASN G  158  GLY G  179  1                                  22    
HELIX   76  76 GLY G  203  ALA G  215  1                                  13    
HELIX   77  77 ASP G  222  SER G  235  1                                  14    
HELIX   78  78 ASP G  236  SER G  239  5                                   4    
HELIX   79  79 GLY G  251  ILE G  255  5                                   5    
HELIX   80  80 SER H   19  LEU H   31  1                                  13    
HELIX   81  81 GLU H   42  LEU H   52  1                                  11    
HELIX   82  82 GLU H   53  LEU H   55  5                                   3    
HELIX   83  83 SER H   69  GLY H   85  1                                  17    
HELIX   84  84 SER H  110  SER H  122  1                                  13    
HELIX   85  85 SER H  122  LYS H  133  1                                  12    
HELIX   86  86 LYS H  134  MET H  136  5                                   3    
HELIX   87  87 ASN H  158  GLY H  179  1                                  22    
HELIX   88  88 ILE H  207  ALA H  215  1                                   9    
HELIX   89  89 ASP H  222  SER H  235  1                                  14    
HELIX   90  90 ASP H  236  SER H  239  5                                   4    
HELIX   91  91 GLY H  251  ILE H  255  5                                   5    
HELIX   92  92 SER I   19  LEU I   31  1                                  13    
HELIX   93  93 LYS I   41  ARG I   43  5                                   3    
HELIX   94  94 SER I   44  LEU I   55  1                                  12    
HELIX   95  95 SER I   69  GLY I   85  1                                  17    
HELIX   96  96 SER I  110  SER I  122  1                                  13    
HELIX   97  97 SER I  122  LYS I  133  1                                  12    
HELIX   98  98 LYS I  134  MET I  136  5                                   3    
HELIX   99  99 VAL I  159  GLY I  179  1                                  21    
HELIX  100 100 LEU I  208  ALA I  215  1                                   8    
HELIX  101 101 ASP I  222  SER I  235  1                                  14    
HELIX  102 102 ASP I  236  SER I  239  5                                   4    
HELIX  103 103 GLY I  251  ILE I  255  5                                   5    
HELIX  104 104 SER J   19  GLN J   30  1                                  12    
HELIX  105 105 GLU J   42  LEU J   55  1                                  14    
HELIX  106 106 SER J   69  GLY J   85  1                                  17    
HELIX  107 107 SER J  110  SER J  122  1                                  13    
HELIX  108 108 SER J  122  LYS J  133  1                                  12    
HELIX  109 109 LYS J  134  MET J  136  5                                   3    
HELIX  110 110 VAL J  159  GLY J  179  1                                  21    
HELIX  111 111 THR J  206  ALA J  215  1                                  10    
HELIX  112 112 ASP J  222  SER J  235  1                                  14    
HELIX  113 113 ASP J  236  SER J  239  5                                   4    
HELIX  114 114 SER K   19  LEU K   31  1                                  13    
HELIX  115 115 ARG K   43  LEU K   55  1                                  13    
HELIX  116 116 SER K   69  GLY K   85  1                                  17    
HELIX  117 117 SER K  110  SER K  122  1                                  13    
HELIX  118 118 SER K  122  LYS K  133  1                                  12    
HELIX  119 119 LYS K  134  MET K  136  5                                   3    
HELIX  120 120 ASN K  158  GLY K  179  1                                  22    
HELIX  121 121 PHE K  204  ALA K  215  1                                  12    
HELIX  122 122 ASP K  222  SER K  235  1                                  14    
HELIX  123 123 ASP K  236  SER K  239  5                                   4    
HELIX  124 124 GLY K  251  ILE K  255  5                                   5    
HELIX  125 125 SER L   19  LEU L   31  1                                  13    
HELIX  126 126 ARG L   43  LEU L   55  1                                  13    
HELIX  127 127 SER L   69  GLY L   85  1                                  17    
HELIX  128 128 SER L  110  SER L  122  1                                  13    
HELIX  129 129 SER L  122  LYS L  133  1                                  12    
HELIX  130 130 LYS L  134  MET L  136  5                                   3    
HELIX  131 131 VAL L  159  GLY L  179  1                                  21    
HELIX  132 132 ASP L  222  SER L  235  1                                  14    
HELIX  133 133 ASP L  236  SER L  239  5                                   4    
SHEET    1  AA 7 LEU A  62  GLN A  64  0                                        
SHEET    2  AA 7 LYS A  34  TYR A  39  1  O  PHE A  37   N  TYR A  63           
SHEET    3  AA 7 THR A   8  MET A  12  1  O  TYR A   9   N  VAL A  36           
SHEET    4  AA 7 GLY A  89  ILE A  94  1  O  GLY A  89   N  VAL A  10           
SHEET    5  AA 7 GLY A 140  THR A 146  1  O  SER A 141   N  VAL A  90           
SHEET    6  AA 7 ILE A 183  ALA A 190  1  O  ARG A 184   N  ILE A 142           
SHEET    7  AA 7 ASN A 245  VAL A 248  1  O  ILE A 246   N  SER A 189           
SHEET    1  BA 7 LEU B  62  GLN B  64  0                                        
SHEET    2  BA 7 LYS B  34  TYR B  39  1  O  PHE B  37   N  TYR B  63           
SHEET    3  BA 7 THR B   8  MET B  12  1  O  TYR B   9   N  VAL B  36           
SHEET    4  BA 7 GLY B  89  SER B  93  1  O  GLY B  89   N  VAL B  10           
SHEET    5  BA 7 GLY B 140  THR B 146  1  O  SER B 141   N  VAL B  90           
SHEET    6  BA 7 ILE B 183  ALA B 190  1  O  ARG B 184   N  ILE B 142           
SHEET    7  BA 7 ASN B 245  VAL B 248  1  O  ILE B 246   N  SER B 189           
SHEET    1  CA 7 LEU C  62  GLN C  64  0                                        
SHEET    2  CA 7 LYS C  34  TYR C  39  1  O  PHE C  37   N  TYR C  63           
SHEET    3  CA 7 THR C   8  MET C  12  1  O  TYR C   9   N  VAL C  36           
SHEET    4  CA 7 GLY C  89  SER C  93  1  O  GLY C  89   N  VAL C  10           
SHEET    5  CA 7 GLY C 140  THR C 146  1  O  SER C 141   N  VAL C  90           
SHEET    6  CA 7 ILE C 183  ALA C 190  1  O  ARG C 184   N  ILE C 142           
SHEET    7  CA 7 ASN C 245  VAL C 248  1  O  ILE C 246   N  SER C 189           
SHEET    1  DA 7 LEU D  62  GLN D  64  0                                        
SHEET    2  DA 7 LYS D  34  TYR D  39  1  O  PHE D  37   N  TYR D  63           
SHEET    3  DA 7 THR D   8  MET D  12  1  O  TYR D   9   N  VAL D  36           
SHEET    4  DA 7 GLY D  89  SER D  93  1  O  GLY D  89   N  VAL D  10           
SHEET    5  DA 7 GLY D 140  THR D 146  1  O  SER D 141   N  VAL D  90           
SHEET    6  DA 7 ILE D 183  SER D 189  1  O  ARG D 184   N  ILE D 142           
SHEET    7  DA 7 ASN D 245  HIS D 247  1  O  ILE D 246   N  SER D 189           
SHEET    1  EA 7 LEU E  62  GLN E  64  0                                        
SHEET    2  EA 7 LYS E  34  TYR E  39  1  O  PHE E  37   N  TYR E  63           
SHEET    3  EA 7 THR E   8  MET E  12  1  O  TYR E   9   N  VAL E  36           
SHEET    4  EA 7 GLY E  89  ILE E  94  1  O  GLY E  89   N  VAL E  10           
SHEET    5  EA 7 GLY E 140  THR E 146  1  O  SER E 141   N  VAL E  90           
SHEET    6  EA 7 ILE E 183  SER E 189  1  O  ARG E 184   N  ILE E 142           
SHEET    7  EA 7 ASN E 245  HIS E 247  1  O  ILE E 246   N  SER E 189           
SHEET    1  FA 7 LEU F  62  GLN F  64  0                                        
SHEET    2  FA 7 LYS F  34  TYR F  39  1  O  PHE F  37   N  TYR F  63           
SHEET    3  FA 7 THR F   8  MET F  12  1  O  TYR F   9   N  VAL F  36           
SHEET    4  FA 7 GLY F  89  ILE F  94  1  O  GLY F  89   N  VAL F  10           
SHEET    5  FA 7 GLY F 140  THR F 146  1  O  SER F 141   N  VAL F  90           
SHEET    6  FA 7 ILE F 183  SER F 189  1  O  ARG F 184   N  ILE F 142           
SHEET    7  FA 7 ASN F 245  HIS F 247  1  O  ILE F 246   N  SER F 189           
SHEET    1  GA 7 LEU G  62  GLN G  64  0                                        
SHEET    2  GA 7 LYS G  34  TYR G  39  1  O  PHE G  37   N  TYR G  63           
SHEET    3  GA 7 THR G   8  MET G  12  1  O  TYR G   9   N  VAL G  36           
SHEET    4  GA 7 GLY G  89  SER G  93  1  O  GLY G  89   N  VAL G  10           
SHEET    5  GA 7 GLY G 140  THR G 145  1  O  SER G 141   N  VAL G  90           
SHEET    6  GA 7 ILE G 183  SER G 189  1  O  ARG G 184   N  ILE G 142           
SHEET    7  GA 7 ASN G 245  HIS G 247  1  O  ILE G 246   N  SER G 189           
SHEET    1  HA 7 HIS H  61  GLN H  64  0                                        
SHEET    2  HA 7 LYS H  34  TYR H  39  1  O  LEU H  35   N  HIS H  61           
SHEET    3  HA 7 THR H   8  MET H  12  1  O  TYR H   9   N  VAL H  36           
SHEET    4  HA 7 GLY H  89  SER H  93  1  O  GLY H  89   N  VAL H  10           
SHEET    5  HA 7 GLY H 140  THR H 146  1  O  SER H 141   N  VAL H  90           
SHEET    6  HA 7 ILE H 183  ALA H 190  1  O  ARG H 184   N  ILE H 142           
SHEET    7  HA 7 ASN H 245  VAL H 248  1  O  ILE H 246   N  SER H 189           
SHEET    1  IA 7 LEU I  62  GLN I  64  0                                        
SHEET    2  IA 7 LYS I  34  TYR I  39  1  O  PHE I  37   N  TYR I  63           
SHEET    3  IA 7 THR I   8  MET I  12  1  O  TYR I   9   N  VAL I  36           
SHEET    4  IA 7 GLY I  89  SER I  93  1  O  GLY I  89   N  VAL I  10           
SHEET    5  IA 7 GLY I 140  THR I 145  1  O  SER I 141   N  VAL I  90           
SHEET    6  IA 7 ILE I 183  SER I 189  1  O  ARG I 184   N  ILE I 142           
SHEET    7  IA 7 ASN I 245  HIS I 247  1  O  ILE I 246   N  SER I 189           
SHEET    1  JA 7 LEU J  62  GLN J  64  0                                        
SHEET    2  JA 7 LYS J  34  TYR J  39  1  O  PHE J  37   N  TYR J  63           
SHEET    3  JA 7 THR J   8  MET J  12  1  O  TYR J   9   N  VAL J  36           
SHEET    4  JA 7 GLY J  89  HIS J  92  1  O  GLY J  89   N  VAL J  10           
SHEET    5  JA 7 GLY J 140  THR J 146  1  O  SER J 141   N  VAL J  90           
SHEET    6  JA 7 ILE J 183  SER J 189  1  O  ARG J 184   N  ILE J 142           
SHEET    7  JA 7 ASN J 245  HIS J 247  1  O  ILE J 246   N  SER J 189           
SHEET    1  KA 7 LEU K  62  GLN K  64  0                                        
SHEET    2  KA 7 LYS K  34  TYR K  39  1  O  PHE K  37   N  TYR K  63           
SHEET    3  KA 7 THR K   8  MET K  12  1  O  TYR K   9   N  VAL K  36           
SHEET    4  KA 7 GLY K  89  SER K  93  1  O  GLY K  89   N  VAL K  10           
SHEET    5  KA 7 GLY K 140  THR K 146  1  O  SER K 141   N  VAL K  90           
SHEET    6  KA 7 ILE K 183  SER K 189  1  O  ARG K 184   N  ILE K 142           
SHEET    7  KA 7 ASN K 245  HIS K 247  1  O  ILE K 246   N  SER K 189           
SHEET    1  LA 7 LEU L  62  GLN L  64  0                                        
SHEET    2  LA 7 LYS L  34  TYR L  39  1  O  PHE L  37   N  TYR L  63           
SHEET    3  LA 7 THR L   8  MET L  12  1  O  TYR L   9   N  VAL L  36           
SHEET    4  LA 7 GLY L  89  SER L  93  1  O  GLY L  89   N  VAL L  10           
SHEET    5  LA 7 GLY L 140  THR L 145  1  O  SER L 141   N  VAL L  90           
SHEET    6  LA 7 ILE L 183  SER L 189  1  O  ARG L 184   N  ILE L 142           
SHEET    7  LA 7 ASN L 245  HIS L 247  1  O  ILE L 246   N  SER L 189           
CRYST1  123.780  123.780  190.110  90.00  90.00 120.00 P 32         36          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.008079  0.004664  0.000000        0.00000                         
SCALE2      0.000000  0.009329  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.005260        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system