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Database: PDB
Entry: 4CL7
LinkDB: 4CL7
Original site: 4CL7 
HEADER    RECEPTOR                                13-JAN-14   4CL7              
TITLE     CRYSTAL STRUCTURE OF VEGFR-1 DOMAIN 2 IN PRESENCE OF COBALT           
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1;             
COMPND   3 CHAIN: A, B, C, D;                                                   
COMPND   4 FRAGMENT: DOMAIN-2, RESIDUES 132-225;                                
COMPND   5 SYNONYM: VEGFR-1, FMS-LIKE TYROSINE KINASE 1, FLT-1, TYROSINE-PROTEI 
COMPND   6 N KINASE FRT, TYROSINE-PROTEIN KINASE RECEPTOR FLT, FLT, VASCULAR    
COMPND   7 PERMEABILITY FACTOR RECEPTOR;                                        
COMPND   8 EC: 2.7.10.1;                                                        
COMPND   9 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE   7 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);                                 
SOURCE   8 EXPRESSION_SYSTEM_VARIANT: ROSETTA-GAMI PLYSS;                       
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PET22                                     
KEYWDS    RECEPTOR, METAL-BINDING                                               
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    J.-F.GAUCHER,M.REILLE-SEROUSSI,N.GAGEY-EILSTEIN,S.BROUSSY,P.CORIC,    
AUTHOR   2 B.SEIJO,M.-B.LASCOMBE,B.GAUTIER,W.-Q.LIU,F.HUGUENOT,N.INGUIMBERT,    
AUTHOR   3 S.BOUAZIZ,M.VIDAL,I.BROUTIN                                          
REVDAT   3   08-MAY-19 4CL7    1       REMARK                                   
REVDAT   2   01-FEB-17 4CL7    1       JRNL                                     
REVDAT   1   28-JAN-15 4CL7    0                                                
JRNL        AUTH   J.-F.GAUCHER,M.REILLE-SEROUSSI,N.GAGEY-EILSTEIN,S.BROUSSY,   
JRNL        AUTH 2 P.CORIC,B.SEIJO,M.-B.LASCOMBE,B.GAUTIER,W.-Q.LIU,F.HUGUENOT, 
JRNL        AUTH 3 N.INGUIMBERT,S.BOUAZIZ,M.VIDAL,I.BROUTIN                     
JRNL        TITL   BIOPHYSICAL STUDIES OF THE INDUCED DIMERIZATION OF HUMAN     
JRNL        TITL 2 VEGF R RECEPTOR 1 BINDING DOMAIN BY DIVALENT METALS          
JRNL        TITL 3 COMPETING WITH VEGF-A                                        
JRNL        REF    PLOS ONE                      V.  11 67755 2016              
JRNL        REFN                   ESSN 1932-6203                               
JRNL        PMID   27942001                                                     
JRNL        DOI    10.1371/JOURNAL.PONE.0167755                                 
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.00 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE)                               
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.00                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 19.47                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.970                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 97.1                           
REMARK   3   NUMBER OF REFLECTIONS             : 26358                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.171                           
REMARK   3   R VALUE            (WORKING SET) : 0.168                           
REMARK   3   FREE R VALUE                     : 0.233                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.900                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 1294                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 19.4700 -  4.1482    0.94     2717   132  0.1656 0.1996        
REMARK   3     2  4.1482 -  3.2977    0.97     2764   150  0.1486 0.2128        
REMARK   3     3  3.2977 -  2.8824    0.98     2810   153  0.1505 0.2213        
REMARK   3     4  2.8824 -  2.6195    0.98     2814   127  0.1655 0.2095        
REMARK   3     5  2.6195 -  2.4321    0.98     2831   138  0.1825 0.3173        
REMARK   3     6  2.4321 -  2.2890    0.98     2778   149  0.1770 0.2591        
REMARK   3     7  2.2890 -  2.1745    0.98     2807   137  0.1850 0.2484        
REMARK   3     8  2.1745 -  2.0800    0.97     2826   139  0.1846 0.2622        
REMARK   3     9  2.0800 -  2.0000    0.97     2717   169  0.1963 0.2716        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.10                                          
REMARK   3   SHRINKAGE RADIUS   : 0.83                                          
REMARK   3   K_SOL              : 0.39                                          
REMARK   3   B_SOL              : 61.07                                         
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.260            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 22.750           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 17.48                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 17.58                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : -0.26890                                             
REMARK   3    B22 (A**2) : 0.20250                                              
REMARK   3    B33 (A**2) : 0.06640                                              
REMARK   3    B12 (A**2) : 0.38280                                              
REMARK   3    B13 (A**2) : -0.18910                                             
REMARK   3    B23 (A**2) : -0.06570                                             
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.006           3107                                  
REMARK   3   ANGLE     :  0.983           4202                                  
REMARK   3   CHIRALITY :  0.063            488                                  
REMARK   3   PLANARITY :  0.005            524                                  
REMARK   3   DIHEDRAL  : 12.826           1181                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 44                                         
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 133:139)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   3.7971 -30.2210  67.1569              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0515 T22:   0.1789                                     
REMARK   3      T33:   0.0861 T12:  -0.0432                                     
REMARK   3      T13:   0.0206 T23:  -0.0043                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.9322 L22:   0.2966                                     
REMARK   3      L33:   2.2521 L12:   0.0177                                     
REMARK   3      L13:   0.7142 L23:  -0.6756                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0547 S12:   0.2479 S13:  -0.4153                       
REMARK   3      S21:   0.0343 S22:   0.2901 S23:   0.1663                       
REMARK   3      S31:   0.0416 S32:  -0.4033 S33:  -0.2410                       
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 140:145)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   5.7055 -33.2826  56.6542              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1168 T22:   0.2121                                     
REMARK   3      T33:   0.3884 T12:  -0.2003                                     
REMARK   3      T13:  -0.0051 T23:  -0.0929                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.5014 L22:   1.3064                                     
REMARK   3      L33:   0.4107 L12:  -0.6423                                     
REMARK   3      L13:   0.1036 L23:  -0.5514                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1290 S12:   0.5240 S13:  -0.8033                       
REMARK   3      S21:   0.1236 S22:  -0.0784 S23:   0.5756                       
REMARK   3      S31:   0.2145 S32:  -0.4610 S33:  -0.0245                       
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 146:158)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  15.3463 -20.4820  56.3342              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0734 T22:   0.0543                                     
REMARK   3      T33:   0.0375 T12:  -0.0143                                     
REMARK   3      T13:   0.0072 T23:  -0.0148                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6032 L22:   0.4637                                     
REMARK   3      L33:   0.4862 L12:   0.4935                                     
REMARK   3      L13:   0.2933 L23:  -0.0603                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0783 S12:  -0.1153 S13:  -0.0586                       
REMARK   3      S21:  -0.2026 S22:  -0.0744 S23:  -0.0447                       
REMARK   3      S31:   0.0328 S32:  -0.0422 S33:   0.0859                       
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 159:166)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   8.3879 -25.8889  75.2560              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.0033 T22:   0.1017                                     
REMARK   3      T33:  -0.0072 T12:  -0.0044                                     
REMARK   3      T13:   0.0980 T23:   0.0062                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2491 L22:   1.5417                                     
REMARK   3      L33:   1.1382 L12:  -0.0514                                     
REMARK   3      L13:  -0.3028 L23:   0.7269                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0193 S12:   0.0380 S13:  -0.0860                       
REMARK   3      S21:   0.4544 S22:   0.3584 S23:  -0.2100                       
REMARK   3      S31:   0.3141 S32:  -0.1031 S33:   0.1037                       
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 167:173)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  18.6312 -33.6844  63.2935              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.0259 T22:  -0.0501                                     
REMARK   3      T33:   0.0513 T12:   0.1786                                     
REMARK   3      T13:   0.0419 T23:   0.0555                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.1578 L22:   3.8392                                     
REMARK   3      L33:   4.0834 L12:  -1.5185                                     
REMARK   3      L13:  -1.3466 L23:  -1.1194                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1608 S12:  -0.5285 S13:   0.0681                       
REMARK   3      S21:  -1.0322 S22:   0.0032 S23:   0.0020                       
REMARK   3      S31:   1.0425 S32:   0.7877 S33:   0.2573                       
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 174:185)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  23.5907 -24.6454  66.0864              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0214 T22:   0.1582                                     
REMARK   3      T33:   0.1103 T12:   0.0018                                     
REMARK   3      T13:   0.0220 T23:   0.0085                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.8479 L22:   1.3084                                     
REMARK   3      L33:   1.8486 L12:  -1.0701                                     
REMARK   3      L13:   1.0862 L23:  -1.4371                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1485 S12:   0.4505 S13:  -0.0172                       
REMARK   3      S21:   0.0652 S22:  -0.5327 S23:  -0.5118                       
REMARK   3      S31:  -0.1246 S32:   0.7305 S33:   0.1247                       
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 186:190)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  11.3444 -19.8544  70.9580              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0790 T22:   0.0681                                     
REMARK   3      T33:   0.0895 T12:   0.0744                                     
REMARK   3      T13:   0.0237 T23:  -0.0146                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.2016 L22:   0.7460                                     
REMARK   3      L33:   0.7002 L12:   1.3660                                     
REMARK   3      L13:  -0.3077 L23:  -0.4463                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2078 S12:  -0.1938 S13:   0.7090                       
REMARK   3      S21:   0.2519 S22:   0.1528 S23:   0.2870                       
REMARK   3      S31:  -0.5127 S32:  -0.1569 S33:  -0.1165                       
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 191:196)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  18.5875 -19.9858  62.9761              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0627 T22:   0.1389                                     
REMARK   3      T33:   0.0289 T12:  -0.0439                                     
REMARK   3      T13:  -0.0423 T23:  -0.0165                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.3063 L22:   0.9272                                     
REMARK   3      L33:   1.3764 L12:  -0.5730                                     
REMARK   3      L13:  -0.0188 L23:   0.9207                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2830 S12:   0.0006 S13:   0.1543                       
REMARK   3      S21:   0.1137 S22:   0.3250 S23:   0.0543                       
REMARK   3      S31:  -0.1387 S32:   0.6850 S33:  -0.0436                       
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    SELECTION: (CHAIN A AND RESID 197:208)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  19.4507 -28.8130  57.8307              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0895 T22:   0.0779                                     
REMARK   3      T33:   0.1054 T12:   0.0108                                     
REMARK   3      T13:   0.0233 T23:   0.0099                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6845 L22:   0.7061                                     
REMARK   3      L33:   0.6774 L12:  -0.2421                                     
REMARK   3      L13:  -0.0377 L23:   0.2823                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0948 S12:   0.0632 S13:   0.1769                       
REMARK   3      S21:   0.0243 S22:   0.0000 S23:   0.0377                       
REMARK   3      S31:   0.1781 S32:   0.0918 S33:  -0.0651                       
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    SELECTION: (CHAIN A AND RESID 209:216)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   9.0235 -37.8742  75.2088              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1493 T22:   0.1051                                     
REMARK   3      T33:   0.1041 T12:   0.0194                                     
REMARK   3      T13:   0.0463 T23:   0.0538                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.7827 L22:   1.7458                                     
REMARK   3      L33:   1.4855 L12:  -0.0687                                     
REMARK   3      L13:   0.0481 L23:  -0.7867                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1284 S12:  -0.2418 S13:  -0.2083                       
REMARK   3      S21:  -0.2525 S22:   0.3555 S23:  -0.0304                       
REMARK   3      S31:   0.3111 S32:  -0.1226 S33:   0.0774                       
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    SELECTION: (CHAIN A AND RESID 217:225)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  12.4281 -28.5265  54.8881              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0596 T22:   0.1159                                     
REMARK   3      T33:   0.0949 T12:  -0.0808                                     
REMARK   3      T13:  -0.0188 T23:  -0.0187                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.8343 L22:   3.0879                                     
REMARK   3      L33:   2.8861 L12:   1.1197                                     
REMARK   3      L13:  -1.4239 L23:  -2.0504                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0313 S12:  -0.3143 S13:   0.0758                       
REMARK   3      S21:  -0.3792 S22:  -0.0919 S23:  -0.1756                       
REMARK   3      S31:   0.4248 S32:   0.5601 S33:  -0.0900                       
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 133:139)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   4.9493 -29.9943  -6.8370              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.0760 T22:   0.1728                                     
REMARK   3      T33:   0.0282 T12:   0.0237                                     
REMARK   3      T13:  -0.1192 T23:   0.0503                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.6304 L22:   0.3914                                     
REMARK   3      L33:   2.5508 L12:   0.3653                                     
REMARK   3      L13:  -1.3339 L23:   0.3829                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2101 S12:   0.2918 S13:   0.1995                       
REMARK   3      S21:  -0.0845 S22:   0.4289 S23:   0.0438                       
REMARK   3      S31:  -0.3713 S32:  -0.0500 S33:  -0.1246                       
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 140:145)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   6.7175 -26.6937   3.0938              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1920 T22:   0.3093                                     
REMARK   3      T33:   0.1555 T12:   0.0733                                     
REMARK   3      T13:   0.0533 T23:   0.0271                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.8798 L22:   1.9155                                     
REMARK   3      L33:   1.1660 L12:  -1.1495                                     
REMARK   3      L13:   0.2749 L23:  -0.6507                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4787 S12:  -0.2208 S13:   0.3974                       
REMARK   3      S21:  -0.2749 S22:  -0.1508 S23:   0.2992                       
REMARK   3      S31:  -0.4787 S32:  -0.2751 S33:  -0.1311                       
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 146:158)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  16.0899 -39.5225   4.4107              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1961 T22:   0.1368                                     
REMARK   3      T33:   0.0708 T12:   0.0497                                     
REMARK   3      T13:   0.0037 T23:   0.0244                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.7494 L22:   1.1017                                     
REMARK   3      L33:   0.5128 L12:  -0.5291                                     
REMARK   3      L13:   0.2016 L23:  -0.5402                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3608 S12:  -0.0432 S13:  -0.0041                       
REMARK   3      S21:   0.7024 S22:   0.1898 S23:   0.0394                       
REMARK   3      S31:  -0.4071 S32:  -0.0619 S33:   0.1033                       
REMARK   3   TLS GROUP : 15                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 159:166)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   9.4601 -34.5171 -14.7713              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0943 T22:   0.1456                                     
REMARK   3      T33:   0.0377 T12:  -0.0394                                     
REMARK   3      T13:  -0.0258 T23:   0.0064                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1659 L22:   0.3688                                     
REMARK   3      L33:   0.1568 L12:  -0.2373                                     
REMARK   3      L13:  -0.0545 L23:  -0.0459                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1719 S12:   0.3580 S13:  -0.1187                       
REMARK   3      S21:  -0.1368 S22:   0.1033 S23:   0.0579                       
REMARK   3      S31:   0.0186 S32:   0.0155 S33:   0.0515                       
REMARK   3   TLS GROUP : 16                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 167:173)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  19.7303 -26.6919  -2.9678              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1081 T22:   0.2084                                     
REMARK   3      T33:   0.0844 T12:  -0.1095                                     
REMARK   3      T13:   0.0196 T23:  -0.0239                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.7030 L22:   1.6270                                     
REMARK   3      L33:   0.9388 L12:   0.6699                                     
REMARK   3      L13:   0.2276 L23:   0.1796                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0390 S12:  -0.0457 S13:   0.7354                       
REMARK   3      S21:   0.2204 S22:  -0.2244 S23:   0.5922                       
REMARK   3      S31:  -0.5096 S32:   0.1110 S33:  -0.0253                       
REMARK   3   TLS GROUP : 17                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 174:185)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  24.5548 -35.6982  -5.5973              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1100 T22:   0.2335                                     
REMARK   3      T33:   0.1695 T12:   0.0359                                     
REMARK   3      T13:  -0.0458 T23:  -0.0312                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.1714 L22:   0.6292                                     
REMARK   3      L33:   0.5703 L12:  -0.2633                                     
REMARK   3      L13:  -0.7247 L23:  -0.1266                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1909 S12:  -0.5371 S13:   0.2666                       
REMARK   3      S21:   0.2162 S22:  -0.1653 S23:  -0.5132                       
REMARK   3      S31:   0.1142 S32:   0.4558 S33:  -0.0177                       
REMARK   3   TLS GROUP : 18                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 186:190)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  12.3617 -40.5284 -10.3294              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0654 T22:   0.1481                                     
REMARK   3      T33:   0.0869 T12:   0.0065                                     
REMARK   3      T13:   0.0475 T23:   0.0005                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.2385 L22:   1.4139                                     
REMARK   3      L33:   3.1728 L12:  -2.6587                                     
REMARK   3      L13:   0.6672 L23:  -0.7677                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0084 S12:   0.2897 S13:  -0.9694                       
REMARK   3      S21:   0.2121 S22:  -0.1121 S23:   0.2739                       
REMARK   3      S31:  -0.0184 S32:   0.7169 S33:   0.0832                       
REMARK   3   TLS GROUP : 19                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 191:196)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  19.5468 -40.3742  -2.2719              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0611 T22:   0.1872                                     
REMARK   3      T33:   0.0344 T12:   0.1167                                     
REMARK   3      T13:   0.0536 T23:   0.0201                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.8270 L22:   1.2154                                     
REMARK   3      L33:   1.1586 L12:   0.4745                                     
REMARK   3      L13:   1.7361 L23:   0.7938                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5788 S12:  -0.1100 S13:  -0.0006                       
REMARK   3      S21:  -0.2786 S22:   0.2833 S23:  -0.0817                       
REMARK   3      S31:   0.2193 S32:   0.4726 S33:   0.1976                       
REMARK   3   TLS GROUP : 20                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 197:208)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  20.4316 -31.3633   2.4460              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0784 T22:   0.1222                                     
REMARK   3      T33:   0.1136 T12:  -0.0514                                     
REMARK   3      T13:  -0.1036 T23:   0.0168                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.3753 L22:   1.1175                                     
REMARK   3      L33:   1.6034 L12:  -0.9492                                     
REMARK   3      L13:   0.5349 L23:  -0.2654                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1542 S12:   0.2179 S13:   0.0782                       
REMARK   3      S21:   0.1737 S22:  -0.1649 S23:  -0.4112                       
REMARK   3      S31:  -0.2911 S32:   0.4287 S33:   0.1995                       
REMARK   3   TLS GROUP : 21                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 209:216)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  10.2607 -22.5649 -14.7962              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0792 T22:   0.1506                                     
REMARK   3      T33:   0.0481 T12:   0.0171                                     
REMARK   3      T13:  -0.0204 T23:  -0.0121                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.4747 L22:   1.5588                                     
REMARK   3      L33:   3.0657 L12:   1.5225                                     
REMARK   3      L13:   0.6572 L23:   0.6379                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4698 S12:  -0.0764 S13:  -0.1058                       
REMARK   3      S21:  -0.1315 S22:   0.1282 S23:  -0.3195                       
REMARK   3      S31:  -0.5687 S32:  -0.2321 S33:   0.1110                       
REMARK   3   TLS GROUP : 22                                                     
REMARK   3    SELECTION: (CHAIN B AND RESID 217:225)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  13.2878 -31.7064   5.3076              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1484 T22:   0.1322                                     
REMARK   3      T33:   0.0902 T12:   0.0678                                     
REMARK   3      T13:  -0.0115 T23:  -0.0191                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.5181 L22:   2.8940                                     
REMARK   3      L33:   5.9559 L12:  -1.0008                                     
REMARK   3      L13:   0.8811 L23:  -3.3565                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1909 S12:   0.0329 S13:  -0.1439                       
REMARK   3      S21:   0.4233 S22:   0.2958 S23:   0.4114                       
REMARK   3      S31:  -0.4872 S32:   0.4031 S33:  -0.2839                       
REMARK   3   TLS GROUP : 23                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 133:139)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  14.1963 -44.7118  41.6534              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0628 T22:   0.0596                                     
REMARK   3      T33:   0.1769 T12:   0.0273                                     
REMARK   3      T13:   0.0635 T23:   0.0096                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2452 L22:   3.0551                                     
REMARK   3      L33:   0.1789 L12:   0.4900                                     
REMARK   3      L13:  -0.0416 L23:  -0.3933                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1327 S12:   0.0859 S13:   0.0564                       
REMARK   3      S21:  -0.2019 S22:  -0.1119 S23:  -1.1453                       
REMARK   3      S31:  -0.0240 S32:   0.0130 S33:  -0.0006                       
REMARK   3   TLS GROUP : 24                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 140:145)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  12.4520 -37.6444  49.2890              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1210 T22:   0.1198                                     
REMARK   3      T33:   0.1525 T12:   0.0584                                     
REMARK   3      T13:  -0.0627 T23:  -0.0201                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.7109 L22:   1.8476                                     
REMARK   3      L33:   4.2840 L12:  -0.7783                                     
REMARK   3      L13:   0.7640 L23:  -0.3553                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1169 S12:   0.0580 S13:   0.4312                       
REMARK   3      S21:   0.0681 S22:  -0.2124 S23:  -0.7301                       
REMARK   3      S31:   0.6144 S32:   0.5092 S33:   0.0344                       
REMARK   3   TLS GROUP : 25                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 146:158)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   3.5031 -30.5205  37.9451              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0716 T22:   0.0768                                     
REMARK   3      T33:   0.0887 T12:   0.0182                                     
REMARK   3      T13:   0.0291 T23:   0.0270                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.4320 L22:   1.2668                                     
REMARK   3      L33:   0.2046 L12:  -0.6496                                     
REMARK   3      L13:  -0.1210 L23:   0.4726                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0798 S12:   0.0273 S13:  -0.1622                       
REMARK   3      S21:  -0.0727 S22:  -0.1138 S23:   0.2150                       
REMARK   3      S31:   0.0048 S32:  -0.0832 S33:   0.0097                       
REMARK   3   TLS GROUP : 26                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 159:166)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   9.8083 -50.0436  34.5243              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1191 T22:  -0.0266                                     
REMARK   3      T33:   0.0614 T12:   0.0250                                     
REMARK   3      T13:   0.0838 T23:  -0.0829                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.3667 L22:   0.6819                                     
REMARK   3      L33:   1.2637 L12:  -0.9383                                     
REMARK   3      L13:   0.2379 L23:  -0.0395                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3383 S12:   0.4763 S13:  -0.0742                       
REMARK   3      S21:  -0.2779 S22:  -0.3105 S23:   0.1396                       
REMARK   3      S31:   0.1680 S32:   0.3211 S33:  -0.2267                       
REMARK   3   TLS GROUP : 27                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 167:173)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -0.6259 -42.6595  46.2137              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2745 T22:   0.0739                                     
REMARK   3      T33:   0.1700 T12:  -0.1018                                     
REMARK   3      T13:   0.0765 T23:  -0.0360                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6114 L22:   1.0178                                     
REMARK   3      L33:   0.6267 L12:   0.2118                                     
REMARK   3      L13:  -0.1372 L23:  -0.7013                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2450 S12:  -0.3003 S13:  -0.2402                       
REMARK   3      S21:   0.9624 S22:  -0.4698 S23:   0.3588                       
REMARK   3      S31:  -0.2714 S32:   0.2200 S33:   0.0722                       
REMARK   3   TLS GROUP : 28                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 174:185)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -5.6103 -41.1066  37.3650              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0546 T22:   0.1666                                     
REMARK   3      T33:   0.1428 T12:   0.0149                                     
REMARK   3      T13:  -0.0071 T23:  -0.0144                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6501 L22:   0.8179                                     
REMARK   3      L33:   0.4348 L12:   0.5953                                     
REMARK   3      L13:  -0.2359 L23:  -0.5603                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0989 S12:  -0.3813 S13:   0.2296                       
REMARK   3      S21:   0.0129 S22:   0.1133 S23:   0.2866                       
REMARK   3      S31:  -0.0456 S32:   0.0106 S33:  -0.1609                       
REMARK   3   TLS GROUP : 29                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 186:190)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   6.4548 -43.2965  30.4180              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1335 T22:   0.2133                                     
REMARK   3      T33:   0.1750 T12:  -0.0149                                     
REMARK   3      T13:   0.0857 T23:  -0.0679                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.4028 L22:   1.1545                                     
REMARK   3      L33:   1.2815 L12:  -1.3933                                     
REMARK   3      L13:   1.7029 L23:  -0.1522                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3167 S12:   1.3740 S13:  -0.3043                       
REMARK   3      S21:  -0.5008 S22:   0.0729 S23:  -0.0161                       
REMARK   3      S31:  -0.4485 S32:   0.5750 S33:  -0.2062                       
REMARK   3   TLS GROUP : 30                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 191:196)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -0.1743 -36.1295  34.3308              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0775 T22:   0.0894                                     
REMARK   3      T33:   0.0860 T12:   0.0106                                     
REMARK   3      T13:  -0.0105 T23:  -0.0004                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6760 L22:   1.3966                                     
REMARK   3      L33:   0.9545 L12:  -0.3718                                     
REMARK   3      L13:   0.7162 L23:  -0.8529                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0513 S12:  -0.1459 S13:  -0.0633                       
REMARK   3      S21:  -0.2354 S22:   0.0661 S23:   0.3045                       
REMARK   3      S31:   0.0674 S32:  -0.0723 S33:  -0.0197                       
REMARK   3   TLS GROUP : 31                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 197:208)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -1.1099 -35.1595  44.5013              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0661 T22:   0.0173                                     
REMARK   3      T33:   0.1015 T12:  -0.0242                                     
REMARK   3      T13:  -0.0129 T23:  -0.0180                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1331 L22:   0.1793                                     
REMARK   3      L33:   0.4383 L12:  -0.2410                                     
REMARK   3      L13:  -0.0697 L23:  -0.0970                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0590 S12:   0.0875 S13:   0.0251                       
REMARK   3      S21:  -0.1102 S22:  -0.0746 S23:  -0.0607                       
REMARK   3      S31:   0.1107 S32:   0.0811 S33:  -0.0330                       
REMARK   3   TLS GROUP : 32                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 209:216)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   9.3693 -55.0410  44.9746              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2152 T22:   0.0088                                     
REMARK   3      T33:   0.1016 T12:   0.0102                                     
REMARK   3      T13:   0.0804 T23:   0.0017                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0344 L22:   0.7194                                     
REMARK   3      L33:   1.0447 L12:  -0.0351                                     
REMARK   3      L13:  -0.0433 L23:  -0.2926                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1089 S12:   0.0840 S13:  -0.0827                       
REMARK   3      S21:  -0.4586 S22:  -0.2154 S23:  -0.4211                       
REMARK   3      S31:   0.2243 S32:   0.1228 S33:   0.2542                       
REMARK   3   TLS GROUP : 33                                                     
REMARK   3    SELECTION: (CHAIN C AND RESID 217:225)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   6.0783 -33.1772  45.5170              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0663 T22:   0.0684                                     
REMARK   3      T33:   0.0704 T12:  -0.0086                                     
REMARK   3      T13:  -0.0304 T23:   0.0046                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1918 L22:   1.7662                                     
REMARK   3      L33:   0.7466 L12:  -0.0488                                     
REMARK   3      L13:  -0.1883 L23:  -0.5076                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1148 S12:   0.0544 S13:  -0.0269                       
REMARK   3      S21:   0.2787 S22:  -0.2833 S23:  -0.1758                       
REMARK   3      S31:  -0.0665 S32:  -0.0234 S33:   0.1151                       
REMARK   3   TLS GROUP : 34                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 133:139)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  15.7145 -14.6196  18.1041              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0912 T22:   0.0912                                     
REMARK   3      T33:   0.2326 T12:  -0.0332                                     
REMARK   3      T13:  -0.0128 T23:   0.0098                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.3403 L22:   1.0228                                     
REMARK   3      L33:   0.8972 L12:   1.1573                                     
REMARK   3      L13:   0.2393 L23:   0.1952                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1593 S12:   0.1154 S13:   0.1235                       
REMARK   3      S21:  -0.2532 S22:   0.1546 S23:  -0.5213                       
REMARK   3      S31:  -0.4405 S32:   0.4512 S33:  -0.0125                       
REMARK   3   TLS GROUP : 35                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 140:145)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  13.7989 -22.0646  10.7167              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3440 T22:   0.4024                                     
REMARK   3      T33:   0.1771 T12:  -0.1896                                     
REMARK   3      T13:   0.1046 T23:  -0.0172                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3482 L22:   0.0089                                     
REMARK   3      L33:   0.5229 L12:  -0.0064                                     
REMARK   3      L13:   0.3540 L23:   0.0330                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0374 S12:   0.6571 S13:   0.1224                       
REMARK   3      S21:  -0.5071 S22:   0.2633 S23:  -0.2433                       
REMARK   3      S31:  -0.7987 S32:   1.0616 S33:  -0.2298                       
REMARK   3   TLS GROUP : 36                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 146:158)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   4.6791 -28.5510  22.1208              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1370 T22:   0.0271                                     
REMARK   3      T33:   0.0838 T12:  -0.0420                                     
REMARK   3      T13:   0.0138 T23:   0.0025                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6464 L22:   0.2653                                     
REMARK   3      L33:   0.7229 L12:  -0.3268                                     
REMARK   3      L13:  -0.0627 L23:   0.1170                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1646 S12:   0.0543 S13:  -0.0340                       
REMARK   3      S21:  -0.0551 S22:   0.0341 S23:  -0.1873                       
REMARK   3      S31:   0.3076 S32:  -0.1154 S33:   0.1122                       
REMARK   3   TLS GROUP : 37                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 159:166)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  11.0304  -9.4914  25.8369              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1971 T22:   0.0368                                     
REMARK   3      T33:   0.1424 T12:   0.0149                                     
REMARK   3      T13:  -0.0873 T23:  -0.0673                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.0763 L22:   0.9916                                     
REMARK   3      L33:   0.7112 L12:   0.7926                                     
REMARK   3      L13:  -0.7745 L23:  -0.4396                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0534 S12:  -0.0037 S13:  -0.1346                       
REMARK   3      S21:  -0.5386 S22:  -0.1777 S23:  -0.2647                       
REMARK   3      S31:  -0.3679 S32:   0.0404 S33:  -0.0023                       
REMARK   3   TLS GROUP : 38                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 167:173)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   1.0121 -16.3755  13.2626              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1437 T22:   0.1767                                     
REMARK   3      T33:   0.0837 T12:  -0.0028                                     
REMARK   3      T13:  -0.0669 T23:   0.0338                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.9160 L22:   1.2374                                     
REMARK   3      L33:   0.5986 L12:  -0.4195                                     
REMARK   3      L13:  -0.3563 L23:  -0.4620                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1618 S12:   0.4138 S13:   0.4339                       
REMARK   3      S21:  -0.3785 S22:   0.0686 S23:   0.1568                       
REMARK   3      S31:  -0.0169 S32:  -0.1659 S33:  -0.0524                       
REMARK   3   TLS GROUP : 39                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 174:185)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  -4.5241 -17.9793  22.3430              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1037 T22:   0.1538                                     
REMARK   3      T33:   0.1385 T12:  -0.0051                                     
REMARK   3      T13:  -0.0186 T23:  -0.0322                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.5297 L22:   0.7183                                     
REMARK   3      L33:   0.9122 L12:   0.1759                                     
REMARK   3      L13:   0.4210 L23:  -0.1272                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2144 S12:   0.3609 S13:  -0.2838                       
REMARK   3      S21:  -0.1379 S22:   0.0931 S23:   0.3793                       
REMARK   3      S31:   0.4335 S32:  -0.0621 S33:  -0.2596                       
REMARK   3   TLS GROUP : 40                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 186:190)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   8.5326 -15.7341  28.9341              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1147 T22:   0.0020                                     
REMARK   3      T33:   0.0737 T12:   0.0247                                     
REMARK   3      T13:  -0.0967 T23:  -0.0213                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.1229 L22:   2.5029                                     
REMARK   3      L33:   3.1042 L12:  -0.2462                                     
REMARK   3      L13:  -2.6685 L23:  -0.2853                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2695 S12:  -0.6049 S13:  -0.2689                       
REMARK   3      S21:   0.8511 S22:  -0.1252 S23:   0.2249                       
REMARK   3      S31:   0.1310 S32:   0.5545 S33:   0.0879                       
REMARK   3   TLS GROUP : 41                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 191:196)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   1.2026 -22.8468  25.5601              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1616 T22:   0.0943                                     
REMARK   3      T33:   0.0330 T12:   0.0184                                     
REMARK   3      T13:   0.0386 T23:  -0.0154                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.6922 L22:   2.3338                                     
REMARK   3      L33:   5.7237 L12:  -1.0920                                     
REMARK   3      L13:  -1.6168 L23:   1.3970                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4854 S12:  -0.1791 S13:  -0.2364                       
REMARK   3      S21:  -0.0392 S22:  -0.2974 S23:   0.0178                       
REMARK   3      S31:   0.4876 S32:  -0.3638 S33:   0.1920                       
REMARK   3   TLS GROUP : 42                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 197:208)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   0.1913 -23.5142  15.4174              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1057 T22:   0.1247                                     
REMARK   3      T33:   0.0756 T12:  -0.0387                                     
REMARK   3      T13:  -0.0983 T23:   0.0128                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.7911 L22:   1.7355                                     
REMARK   3      L33:   1.3278 L12:   1.7187                                     
REMARK   3      L13:  -1.4537 L23:  -1.1896                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0685 S12:   0.4818 S13:   0.5737                       
REMARK   3      S21:  -0.1427 S22:   0.3207 S23:   0.6148                       
REMARK   3      S31:  -0.1445 S32:  -0.4642 S33:   0.0796                       
REMARK   3   TLS GROUP : 43                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 209:216)                            
REMARK   3    ORIGIN FOR THE GROUP (A):  11.3160  -4.4440  14.9220              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3316 T22:   0.0375                                     
REMARK   3      T33:   0.3976 T12:  -0.1563                                     
REMARK   3      T13:  -0.1624 T23:   0.1899                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2684 L22:   0.5311                                     
REMARK   3      L33:   0.6976 L12:   0.3444                                     
REMARK   3      L13:  -0.0138 L23:   0.2647                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3557 S12:   0.5028 S13:   0.3553                       
REMARK   3      S21:   0.2712 S22:  -0.4906 S23:  -0.4213                       
REMARK   3      S31:  -0.6088 S32:   0.9167 S33:   0.6006                       
REMARK   3   TLS GROUP : 44                                                     
REMARK   3    SELECTION: (CHAIN D AND RESID 217:225)                            
REMARK   3    ORIGIN FOR THE GROUP (A):   7.4304 -26.1434  14.4138              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1673 T22:   0.0706                                     
REMARK   3      T33:  -0.0226 T12:  -0.0194                                     
REMARK   3      T13:   0.1055 T23:   0.0724                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.4996 L22:   0.9822                                     
REMARK   3      L33:   0.3482 L12:   1.1597                                     
REMARK   3      L13:  -0.1606 L23:  -0.1445                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0079 S12:  -0.3999 S13:   0.3082                       
REMARK   3      S21:   0.0986 S22:  -0.2203 S23:   0.4855                       
REMARK   3      S31:   0.1748 S32:   0.0575 S33:   0.0320                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 4CL7 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 13-JAN-14.                  
REMARK 100 THE DEPOSITION ID IS D_1290059391.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 06-NOV-09                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 7.0                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : ESRF                               
REMARK 200  BEAMLINE                       : ID23-2                             
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.8726                             
REMARK 200  MONOCHROMATOR                  : SI(111)                            
REMARK 200  OPTICS                         : KIRKPATRICK-BAEZ MIRRORSWITH PT    
REMARK 200                                   COATING                            
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC CCD                           
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK                          
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 26362                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.000                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 19.470                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 2.000                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 97.1                               
REMARK 200  DATA REDUNDANCY                : 1.800                              
REMARK 200  R MERGE                    (I) : 0.07000                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 10.7400                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.00                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.07                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 96.6                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 1.80                               
REMARK 200  R MERGE FOR SHELL          (I) : 0.33000                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 3.010                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHENIX                                                
REMARK 200 STARTING MODEL: PDB ENTRY 1FLT                                       
REMARK 200                                                                      
REMARK 200 REMARK: NONE                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 47.90                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.36                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: CRYSTAL WERE OBTAINED BY HANGING DROP    
REMARK 280  METHOD FROM 1MM VEGFR1-D2, 5MM HEPES/NAOH PH7.0, 10MM COCL2, 100    
REMARK 280  MM BIS-TRIS/HCL PH6.5 15%(W/V) PEG3350., VAPOR DIFFUSION,           
REMARK 280  HANGING DROP                                                        
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1                              
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 1610 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 10910 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -28.2 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 1550 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 11160 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -22.1 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, D                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     GLY A   132                                                      
REMARK 465     GLY B   132                                                      
REMARK 465     GLY C   132                                                      
REMARK 465     GLY D   132                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    SER A 140      -79.94   -109.54                                   
REMARK 500    LYS A 182      -72.24   -137.38                                   
REMARK 500    LYS A 190      -44.89   -134.24                                   
REMARK 500    GLU B 141      -69.96   -108.03                                   
REMARK 500    PRO B 157       46.23    -84.86                                   
REMARK 500    LYS B 182      -83.88   -129.44                                   
REMARK 500    TYR C 139       78.49   -110.19                                   
REMARK 500    PRO C 157       44.55    -81.84                                   
REMARK 500    PRO D 157       40.05    -82.93                                   
REMARK 500    LYS D 182      -73.78   -127.35                                   
REMARK 500    LYS D 190      -37.57   -135.24                                   
REMARK 500    ASN D 212       42.71     37.80                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CO A1226  CO                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS C 223   NE2                                                    
REMARK 620 2 HOH A2009   O    88.7                                              
REMARK 620 3 HIS C 147   NE2  89.2  89.6                                        
REMARK 620 4 HIS A 147   NE2  91.5  85.5 175.1                                  
REMARK 620 5 HIS A 223   NE2  96.4 173.1  85.8  99.0                            
REMARK 620 6 HOH A2010   O   174.9  90.1  85.9  93.4  84.3                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CO A1227  CO                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HOH A2077   O                                                      
REMARK 620 2 HIS A 214   NE2 152.4                                              
REMARK 620 3 HOH A2067   O   136.8  70.2                                        
REMARK 620 4 HOH A2068   O   108.9  86.3  64.7                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CO B1226  CO                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS D 147   NE2                                                    
REMARK 620 2 HIS B 147   NE2 173.3                                              
REMARK 620 3 HIS D 223   NE2 100.7  81.4                                        
REMARK 620 4 HIS B 223   NE2  81.4 104.2 105.1                                  
REMARK 620 5 HOH B2062   O    70.1 107.9 170.7  73.3                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CO B1227  CO                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS B 214   NE2                                                    
REMARK 620 2 HOH B2057   O    80.7                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CO C1226  CO                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HOH C2071   O                                                      
REMARK 620 2 HOH C2070   O    78.6                                              
REMARK 620 3 HOH C2062   O    85.2  81.1                                        
REMARK 620 4 HOH C2068   O   100.5  59.2 137.2                                  
REMARK 620 5 HIS C 214   NE2 113.0 167.6 103.8 112.4                            
REMARK 620 6 HOH C2061   O   156.1  77.5  91.7  66.3  90.8                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CO A 1226                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CO B 1226                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CO C 1226                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CO A 1227                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CO B 1227                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE EDO A 1228                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE EDO A 1229                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE EDO A 1230                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE EDO B 1228                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE EDO B 1229                
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 4CKV   RELATED DB: PDB                                   
REMARK 900 CRYSTAL STRUCTURE OF VEGFR-1 DOMAIN 2 IN PRESENCE OF ZN              
DBREF  4CL7 A  132   225  UNP    P17948   VGFR1_HUMAN    132    225             
DBREF  4CL7 B  132   225  UNP    P17948   VGFR1_HUMAN    132    225             
DBREF  4CL7 C  132   225  UNP    P17948   VGFR1_HUMAN    132    225             
DBREF  4CL7 D  132   225  UNP    P17948   VGFR1_HUMAN    132    225             
SEQRES   1 A   94  GLY ARG PRO PHE VAL GLU MET TYR SER GLU ILE PRO GLU          
SEQRES   2 A   94  ILE ILE HIS MET THR GLU GLY ARG GLU LEU VAL ILE PRO          
SEQRES   3 A   94  CYS ARG VAL THR SER PRO ASN ILE THR VAL THR LEU LYS          
SEQRES   4 A   94  LYS PHE PRO LEU ASP THR LEU ILE PRO ASP GLY LYS ARG          
SEQRES   5 A   94  ILE ILE TRP ASP SER ARG LYS GLY PHE ILE ILE SER ASN          
SEQRES   6 A   94  ALA THR TYR LYS GLU ILE GLY LEU LEU THR CYS GLU ALA          
SEQRES   7 A   94  THR VAL ASN GLY HIS LEU TYR LYS THR ASN TYR LEU THR          
SEQRES   8 A   94  HIS ARG GLN                                                  
SEQRES   1 B   94  GLY ARG PRO PHE VAL GLU MET TYR SER GLU ILE PRO GLU          
SEQRES   2 B   94  ILE ILE HIS MET THR GLU GLY ARG GLU LEU VAL ILE PRO          
SEQRES   3 B   94  CYS ARG VAL THR SER PRO ASN ILE THR VAL THR LEU LYS          
SEQRES   4 B   94  LYS PHE PRO LEU ASP THR LEU ILE PRO ASP GLY LYS ARG          
SEQRES   5 B   94  ILE ILE TRP ASP SER ARG LYS GLY PHE ILE ILE SER ASN          
SEQRES   6 B   94  ALA THR TYR LYS GLU ILE GLY LEU LEU THR CYS GLU ALA          
SEQRES   7 B   94  THR VAL ASN GLY HIS LEU TYR LYS THR ASN TYR LEU THR          
SEQRES   8 B   94  HIS ARG GLN                                                  
SEQRES   1 C   94  GLY ARG PRO PHE VAL GLU MET TYR SER GLU ILE PRO GLU          
SEQRES   2 C   94  ILE ILE HIS MET THR GLU GLY ARG GLU LEU VAL ILE PRO          
SEQRES   3 C   94  CYS ARG VAL THR SER PRO ASN ILE THR VAL THR LEU LYS          
SEQRES   4 C   94  LYS PHE PRO LEU ASP THR LEU ILE PRO ASP GLY LYS ARG          
SEQRES   5 C   94  ILE ILE TRP ASP SER ARG LYS GLY PHE ILE ILE SER ASN          
SEQRES   6 C   94  ALA THR TYR LYS GLU ILE GLY LEU LEU THR CYS GLU ALA          
SEQRES   7 C   94  THR VAL ASN GLY HIS LEU TYR LYS THR ASN TYR LEU THR          
SEQRES   8 C   94  HIS ARG GLN                                                  
SEQRES   1 D   94  GLY ARG PRO PHE VAL GLU MET TYR SER GLU ILE PRO GLU          
SEQRES   2 D   94  ILE ILE HIS MET THR GLU GLY ARG GLU LEU VAL ILE PRO          
SEQRES   3 D   94  CYS ARG VAL THR SER PRO ASN ILE THR VAL THR LEU LYS          
SEQRES   4 D   94  LYS PHE PRO LEU ASP THR LEU ILE PRO ASP GLY LYS ARG          
SEQRES   5 D   94  ILE ILE TRP ASP SER ARG LYS GLY PHE ILE ILE SER ASN          
SEQRES   6 D   94  ALA THR TYR LYS GLU ILE GLY LEU LEU THR CYS GLU ALA          
SEQRES   7 D   94  THR VAL ASN GLY HIS LEU TYR LYS THR ASN TYR LEU THR          
SEQRES   8 D   94  HIS ARG GLN                                                  
HET     CO  A1226       1                                                       
HET     CO  A1227       1                                                       
HET    EDO  A1228       4                                                       
HET    EDO  A1229       4                                                       
HET    EDO  A1230       4                                                       
HET     CO  B1226       1                                                       
HET     CO  B1227       1                                                       
HET    EDO  B1228       4                                                       
HET    EDO  B1229       4                                                       
HET     CO  C1226       1                                                       
HETNAM      CO COBALT (II) ION                                                  
HETNAM     EDO 1,2-ETHANEDIOL                                                   
HETSYN     EDO ETHYLENE GLYCOL                                                  
FORMUL   5   CO    5(CO 2+)                                                     
FORMUL   7  EDO    5(C2 H6 O2)                                                  
FORMUL  15  HOH   *281(H2 O)                                                    
HELIX    1   1 THR A  198  ILE A  202  5                                   5    
HELIX    2   2 THR B  198  ILE B  202  5                                   5    
HELIX    3   3 THR C  198  ILE C  202  5                                   5    
HELIX    4   4 THR D  198  ILE D  202  5                                   5    
SHEET    1  AA 5 GLU A 144  MET A 148  0                                        
SHEET    2  AA 5 HIS A 214  ARG A 224  1  O  ASN A 219   N  GLU A 144           
SHEET    3  AA 5 LEU A 204  VAL A 211 -1  O  LEU A 205   N  TYR A 220           
SHEET    4  AA 5 VAL A 167  LYS A 171 -1  O  THR A 168   N  GLU A 208           
SHEET    5  AA 5 ASP A 175  LEU A 177 -1  O  ASP A 175   N  LYS A 171           
SHEET    1  AB 3 LEU A 154  ILE A 156  0                                        
SHEET    2  AB 3 GLY A 191  ILE A 194 -1  O  PHE A 192   N  ILE A 156           
SHEET    3  AB 3 ILE A 184  ASP A 187 -1  O  ILE A 185   N  ILE A 193           
SHEET    1  BA 5 GLU B 144  MET B 148  0                                        
SHEET    2  BA 5 HIS B 214  ARG B 224  1  O  ASN B 219   N  GLU B 144           
SHEET    3  BA 5 GLY B 203  VAL B 211 -1  O  GLY B 203   N  THR B 222           
SHEET    4  BA 5 VAL B 167  LYS B 171 -1  O  THR B 168   N  GLU B 208           
SHEET    5  BA 5 ASP B 175  LEU B 177 -1  O  ASP B 175   N  LYS B 171           
SHEET    1  BB 3 LEU B 154  ILE B 156  0                                        
SHEET    2  BB 3 GLY B 191  ILE B 194 -1  O  PHE B 192   N  ILE B 156           
SHEET    3  BB 3 ILE B 184  ASP B 187 -1  O  ILE B 185   N  ILE B 193           
SHEET    1  CA 5 GLU C 144  MET C 148  0                                        
SHEET    2  CA 5 HIS C 214  ARG C 224  1  O  ASN C 219   N  GLU C 144           
SHEET    3  CA 5 GLY C 203  VAL C 211 -1  O  GLY C 203   N  THR C 222           
SHEET    4  CA 5 VAL C 167  LYS C 171 -1  O  THR C 168   N  GLU C 208           
SHEET    5  CA 5 ASP C 175  LEU C 177 -1  O  ASP C 175   N  LYS C 171           
SHEET    1  CB 3 LEU C 154  ILE C 156  0                                        
SHEET    2  CB 3 GLY C 191  ILE C 194 -1  O  PHE C 192   N  ILE C 156           
SHEET    3  CB 3 ILE C 184  ASP C 187 -1  O  ILE C 185   N  ILE C 193           
SHEET    1  DA 5 GLU D 144  MET D 148  0                                        
SHEET    2  DA 5 HIS D 214  ARG D 224  1  O  ASN D 219   N  GLU D 144           
SHEET    3  DA 5 GLY D 203  VAL D 211 -1  O  GLY D 203   N  THR D 222           
SHEET    4  DA 5 VAL D 167  LYS D 171 -1  O  THR D 168   N  GLU D 208           
SHEET    5  DA 5 ASP D 175  LEU D 177 -1  O  ASP D 175   N  LYS D 171           
SHEET    1  DB 3 LEU D 154  ILE D 156  0                                        
SHEET    2  DB 3 GLY D 191  ILE D 194 -1  O  PHE D 192   N  ILE D 156           
SHEET    3  DB 3 ILE D 184  ASP D 187 -1  O  ILE D 185   N  ILE D 193           
SSBOND   1 CYS A  158    CYS A  207                          1555   1555  2.08  
SSBOND   2 CYS B  158    CYS B  207                          1555   1555  2.06  
SSBOND   3 CYS C  158    CYS C  207                          1555   1555  2.06  
SSBOND   4 CYS D  158    CYS D  207                          1555   1555  2.06  
LINK        CO    CO A1226                 NE2 HIS C 223     1555   1555  2.20  
LINK        CO    CO A1226                 O   HOH A2009     1555   1555  2.25  
LINK        CO    CO A1226                 NE2 HIS C 147     1555   1555  2.20  
LINK        CO    CO A1226                 NE2 HIS A 147     1555   1555  2.26  
LINK        CO    CO A1226                 NE2 HIS A 223     1555   1555  2.35  
LINK        CO    CO A1226                 O   HOH A2010     1555   1555  2.23  
LINK        CO    CO A1227                 O   HOH A2077     1555   1555  2.77  
LINK        CO    CO A1227                 NE2 HIS A 214     1555   1555  2.37  
LINK        CO    CO A1227                 O   HOH A2067     1555   1555  2.58  
LINK        CO    CO A1227                 O   HOH A2068     1555   1555  2.48  
LINK        CO    CO B1226                 NE2 HIS D 147     1555   1555  2.47  
LINK        CO    CO B1226                 NE2 HIS B 147     1555   1555  2.49  
LINK        CO    CO B1226                 NE2 HIS D 223     1555   1555  2.20  
LINK        CO    CO B1226                 NE2 HIS B 223     1555   1555  2.40  
LINK        CO    CO B1226                 O   HOH B2062     1555   1555  2.33  
LINK        CO    CO B1227                 NE2 HIS B 214     1555   1555  2.58  
LINK        CO    CO B1227                 O   HOH B2057     1555   1555  2.51  
LINK        CO    CO C1226                 O   HOH C2071     1555   1555  2.26  
LINK        CO    CO C1226                 O   HOH C2070     1555   1555  2.54  
LINK        CO    CO C1226                 O   HOH C2062     1555   1555  2.23  
LINK        CO    CO C1226                 O   HOH C2068     1555   1555  2.56  
LINK        CO    CO C1226                 NE2 HIS C 214     1555   1555  2.13  
LINK        CO    CO C1226                 O   HOH C2061     1555   1555  2.79  
CISPEP   1 PHE A  172    PRO A  173          0        -0.47                     
CISPEP   2 PHE B  172    PRO B  173          0        -3.79                     
CISPEP   3 PHE C  172    PRO C  173          0        -3.77                     
CISPEP   4 PHE D  172    PRO D  173          0        -0.76                     
SITE     1 AC1  6 HIS A 147  HIS A 223  HOH A2009  HOH A2010                    
SITE     2 AC1  6 HIS C 147  HIS C 223                                          
SITE     1 AC2  5 HIS B 147  HIS B 223  HOH B2062  HIS D 147                    
SITE     2 AC2  5 HIS D 223                                                     
SITE     1 AC3  6 HIS C 214  HOH C2061  HOH C2062  HOH C2068                    
SITE     2 AC3  6 HOH C2070  HOH C2071                                          
SITE     1 AC4  5 HIS A 214  HOH A2065  HOH A2067  HOH A2068                    
SITE     2 AC4  5 HOH A2077                                                     
SITE     1 AC5  2 HIS B 214  HOH B2057                                          
SITE     1 AC6  5 VAL A 160  THR A 161  PRO A 163  SER A 188                    
SITE     2 AC6  5 HOH A2024                                                     
SITE     1 AC7  7 ASN A 164  ILE A 165  THR A 166  THR A 210                    
SITE     2 AC7  7 VAL A 211  EDO A1230  THR B 161                               
SITE     1 AC8  7 THR A 166  ALA A 209  THR A 210  EDO A1229                    
SITE     2 AC8  7 HOH A2063  THR B 161  HOH B2021                               
SITE     1 AC9  5 THR A 161  ASN B 164  THR B 166  THR B 210                    
SITE     2 AC9  5 EDO B1229                                                     
SITE     1 BC1  6 THR A 161  THR B 166  ALA B 209  THR B 210                    
SITE     2 BC1  6 EDO B1228  HOH B2052                                          
CRYST1   27.746   41.711   94.694  87.05  82.25  73.03 P 1           4          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.036041 -0.010998 -0.004765        0.00000                         
SCALE2      0.000000  0.025066 -0.000320        0.00000                         
SCALE3      0.000000  0.000000  0.010659        0.00000                         
MTRIX1   1  0.999830 -0.016210  0.008620        0.07169    1                    
MTRIX2   1 -0.016040 -0.999690 -0.019100      -58.84029    1                    
MTRIX3   1  0.008930  0.018960 -0.999780       60.80122    1                    
MTRIX1   2 -0.999960 -0.006180 -0.006770       19.89528    1                    
MTRIX2   2 -0.003340 -0.442640  0.896690      -88.16490    1                    
MTRIX3   2 -0.008540  0.896680  0.442600       15.62318    1                    
MTRIX1   3 -0.999430  0.016260 -0.029540       20.52068    1                    
MTRIX2   3  0.033700  0.448680 -0.893060       28.48222    1                    
MTRIX3   3 -0.001270 -0.893550 -0.448970       44.82311    1                    
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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