GenomeNet

Database: PDB
Entry: 4CR3
LinkDB: 4CR3
Original site: 4CR3 
HEADER    HYDROLASE                               25-FEB-14   4CR3              
TITLE     DEEP CLASSIFICATION OF A LARGE CRYO-EM DATASET DEFINES THE            
TITLE    2 CONFORMATIONAL LANDSCAPE OF THE 26S PROTEASOME                       
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PROTEASOME COMPONENT PRE3;                                 
COMPND   3 CHAIN: 1;                                                            
COMPND   4 SYNONYM: 20S PROTEASOME BETA SUBUNIT 1, MACROPAIN SUBUNIT PRE3,      
COMPND   5 MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE3, PROTEINASE YSCE   
COMPND   6 SUBUNIT PRE3;                                                        
COMPND   7 EC: 3.4.25.1;                                                        
COMPND   8 MOL_ID: 2;                                                           
COMPND   9 MOLECULE: PROTEASOME COMPONENT PUP1;                                 
COMPND  10 CHAIN: 2;                                                            
COMPND  11 SYNONYM: 20S PROTEASOME BETA SUBUNIT 2 MACROPAIN SUBUNIT PUP1,       
COMPND  12 MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PUP1, PROTEINASE YSCE   
COMPND  13 SUBUNIT PUP1;                                                        
COMPND  14 EC: 3.4.25.1;                                                        
COMPND  15 MOL_ID: 3;                                                           
COMPND  16 MOLECULE: PROTEASOME COMPONENT PUP3;                                 
COMPND  17 CHAIN: 3;                                                            
COMPND  18 SYNONYM: 20S PROTEASOME BETA SUBUNIT 3, MACROPAIN SUBUNIT PUP3,      
COMPND  19 MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PUP3;                   
COMPND  20 EC: 3.4.25.1;                                                        
COMPND  21 MOL_ID: 4;                                                           
COMPND  22 MOLECULE: PROTEASOME COMPONENT C11;                                  
COMPND  23 CHAIN: 4;                                                            
COMPND  24 SYNONYM: 20S PROTEASOME BETA SUBUNIT 4, MACROPAIN SUBUNIT C11,       
COMPND  25 MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C11, PROTEINASE YSCE    
COMPND  26 SUBUNIT 11;                                                          
COMPND  27 EC: 3.4.25.1;                                                        
COMPND  28 MOL_ID: 5;                                                           
COMPND  29 MOLECULE: PROTEASOME COMPONENT PRE2;                                 
COMPND  30 CHAIN: 5;                                                            
COMPND  31 SYNONYM: 20S PROTEASOME BETA SUBUNIT 5, MACROPAIN SUBUNIT PRE2,      
COMPND  32 MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE2, PROTEINASE YSCE   
COMPND  33 SUBUNIT PRE2;                                                        
COMPND  34 EC: 3.4.25.1;                                                        
COMPND  35 MOL_ID: 6;                                                           
COMPND  36 MOLECULE: PROTEASOME COMPONENT C5;                                   
COMPND  37 CHAIN: 6;                                                            
COMPND  38 SYNONYM: 20S PROTEASOME BETA SUBUNIT 6, MULTICATALYTIC ENDOPEPTIDASE;
COMPND  39 EC: 3.4.25.1;                                                        
COMPND  40 MOL_ID: 7;                                                           
COMPND  41 MOLECULE: PROTEASOME COMPONENT PRE4;                                 
COMPND  42 CHAIN: 7;                                                            
COMPND  43 SYNONYM: 20S PROTEASOME BETA SUBUNIT 7, MACROPAIN SUBUNIT PRE4,      
COMPND  44 MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE4, PROTEINASE YSCE   
COMPND  45 SUBUNIT PRE4;                                                        
COMPND  46 EC: 3.4.25.1;                                                        
COMPND  47 MOL_ID: 8;                                                           
COMPND  48 MOLECULE: PROTEASOME COMPONENT C7-ALPHA;                             
COMPND  49 CHAIN: A;                                                            
COMPND  50 SYNONYM: 20S PROTEASOME ALPHA SUBUNIT 1, MACROPAIN SUBUNIT C7-ALPHA, 
COMPND  51 MULTICATALYTIC ENDOPEPTIDASE COMPLEX C7, PROTEASOME COMPONENT Y8,    
COMPND  52 PROTEINASE YSCE SUBUNIT 7, SCL1 SUPPRESSOR PROTEIN;                  
COMPND  53 EC: 3.4.25.1;                                                        
COMPND  54 MOL_ID: 9;                                                           
COMPND  55 MOLECULE: PROTEASOME COMPONENT Y7;                                   
COMPND  56 CHAIN: B;                                                            
COMPND  57 SYNONYM: 20S PROTEASOME ALPHA SUBUNIT 2, MACROPAIN SUBUNIT Y7,       
COMPND  58 MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT Y7, PROTEINASE YSCE     
COMPND  59 SUBUNIT 7;                                                           
COMPND  60 EC: 3.4.25.1;                                                        
COMPND  61 MOL_ID: 10;                                                          
COMPND  62 MOLECULE: PROTEASOME COMPONENT Y13;                                  
COMPND  63 CHAIN: C;                                                            
COMPND  64 SYNONYM: 20S PROTEASOME ALPHA SUBUNIT 3, MACROPAIN SUBUNIT Y13,      
COMPND  65 MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT Y13, PROTEINASE YSCE    
COMPND  66 SUBUNIT 13;                                                          
COMPND  67 EC: 3.4.25.1;                                                        
COMPND  68 MOL_ID: 11;                                                          
COMPND  69 MOLECULE: PROTEASOME COMPONENT PRE6;                                 
COMPND  70 CHAIN: D;                                                            
COMPND  71 SYNONYM: 20S PROTEASOME ALPHA SUBUNIT 4, MACROPAIN SUBUNIT PRE6,     
COMPND  72 MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE6, PROTEINASE YSCE   
COMPND  73 SUBUNIT PRE6;                                                        
COMPND  74 EC: 3.4.25.1;                                                        
COMPND  75 MOL_ID: 12;                                                          
COMPND  76 MOLECULE: PROTEASOME COMPONENT PUP2;                                 
COMPND  77 CHAIN: E;                                                            
COMPND  78 SYNONYM: 20S PROTEASOME ALPHA SUBUNIT 5, MACROPAIN SUBUNIT PUP2,     
COMPND  79 MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PUP2, PROTEINASE YSCE   
COMPND  80 SUBUNIT PUP2;                                                        
COMPND  81 EC: 3.4.25.1;                                                        
COMPND  82 MOL_ID: 13;                                                          
COMPND  83 MOLECULE: PROTEASOME COMPONENT PRE5;                                 
COMPND  84 CHAIN: F;                                                            
COMPND  85 SYNONYM: 20S PROTEASOME ALPHA SUBUNIT 6, MACROPAIN SUBUNIT PRE5,     
COMPND  86 MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT PRE5, PROTEINASE YSCE   
COMPND  87 SUBUNIT PRE5;                                                        
COMPND  88 EC: 3.4.25.1;                                                        
COMPND  89 MOL_ID: 14;                                                          
COMPND  90 MOLECULE: PROTEASOME COMPONENT C1;                                   
COMPND  91 CHAIN: G;                                                            
COMPND  92 SYNONYM: 20S PROTEASOME ALPHA SUBUNIT 7, MACROPAIN SUBUNIT C1,       
COMPND  93 MULTICATALYTIC ENDOPEPTIDASE COMPLEX SUBUNIT C1, PROTEINASE YSCE     
COMPND  94 SUBUNIT 1;                                                           
COMPND  95 EC: 3.4.25.1;                                                        
COMPND  96 MOL_ID: 15;                                                          
COMPND  97 MOLECULE: 26S PROTEASE REGULATORY SUBUNIT 7 HOMOLOG;                 
COMPND  98 CHAIN: H;                                                            
COMPND  99 SYNONYM: RPT1, PROTEIN CIM5, TAT-BINDING HOMOLOG 3;                  
COMPND 100 MOL_ID: 16;                                                          
COMPND 101 MOLECULE: 26S PROTEASE REGULATORY SUBUNIT 4 HOMOLOG;                 
COMPND 102 CHAIN: I;                                                            
COMPND 103 SYNONYM: RPT2, TAT-BINDING HOMOLOG 5;                                
COMPND 104 MOL_ID: 17;                                                          
COMPND 105 MOLECULE: 26S PROTEASE REGULATORY SUBUNIT 8 HOMOLOG;                 
COMPND 106 CHAIN: J;                                                            
COMPND 107 SYNONYM: RPT6, PROTEIN CIM3, PROTEIN SUG1, TAT-BINDING PROTEIN TBY1; 
COMPND 108 MOL_ID: 18;                                                          
COMPND 109 MOLECULE: 26S PROTEASE REGULATORY SUBUNIT 6B HOMOLOG;                
COMPND 110 CHAIN: K;                                                            
COMPND 111 SYNONYM: RPT3, PROTEIN YNT1, TAT-BINDING HOMOLOG 2;                  
COMPND 112 MOL_ID: 19;                                                          
COMPND 113 MOLECULE: 26S PROTEASE SUBUNIT RPT4;                                 
COMPND 114 CHAIN: L;                                                            
COMPND 115 SYNONYM: RPT4,26S PROTEASE SUBUNIT SUG2, PROTEASOMAL CAP SUBUNIT;    
COMPND 116 MOL_ID: 20;                                                          
COMPND 117 MOLECULE: 26S PROTEASE REGULATORY SUBUNIT 6A;                        
COMPND 118 CHAIN: M;                                                            
COMPND 119 SYNONYM: RPT5, TAT-BINDING PROTEIN HOMOLOG 1, TBP-1;                 
COMPND 120 MOL_ID: 21;                                                          
COMPND 121 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT RPN2;                    
COMPND 122 CHAIN: N;                                                            
COMPND 123 SYNONYM: RPN2;                                                       
COMPND 124 MOL_ID: 22;                                                          
COMPND 125 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT RPN9;                    
COMPND 126 CHAIN: O;                                                            
COMPND 127 SYNONYM: RPN9, PROTEASOME NON-ATPASE SUBUNIT 7;                      
COMPND 128 MOL_ID: 23;                                                          
COMPND 129 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT RPN5;                    
COMPND 130 CHAIN: P;                                                            
COMPND 131 SYNONYM: RPN5, PROTEASOME NON-ATPASE SUBUNIT 5;                      
COMPND 132 MOL_ID: 24;                                                          
COMPND 133 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT RPN6;                    
COMPND 134 CHAIN: Q;                                                            
COMPND 135 SYNONYM: RPN6, PROTEASOME NON-ATPASE SUBUNIT 4;                      
COMPND 136 MOL_ID: 25;                                                          
COMPND 137 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT RPN7;                    
COMPND 138 CHAIN: R;                                                            
COMPND 139 SYNONYM: RPN7;                                                       
COMPND 140 MOL_ID: 26;                                                          
COMPND 141 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT RPN3;                    
COMPND 142 CHAIN: S;                                                            
COMPND 143 SYNONYM: RPN3;                                                       
COMPND 144 MOL_ID: 27;                                                          
COMPND 145 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT RPN12;                   
COMPND 146 CHAIN: T;                                                            
COMPND 147 SYNONYM: RPN12, NUCLEAR INTEGRITY PROTEIN 1;                         
COMPND 148 MOL_ID: 28;                                                          
COMPND 149 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT RPN8;                    
COMPND 150 CHAIN: U;                                                            
COMPND 151 SYNONYM: RPN8;                                                       
COMPND 152 MOL_ID: 29;                                                          
COMPND 153 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT RPN11;                   
COMPND 154 CHAIN: V;                                                            
COMPND 155 SYNONYM: RPN11, PROTEIN MPR1;                                        
COMPND 156 MOL_ID: 30;                                                          
COMPND 157 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT RPN10;                   
COMPND 158 CHAIN: W;                                                            
COMPND 159 SYNONYM: RPN10;                                                      
COMPND 160 MOL_ID: 31;                                                          
COMPND 161 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT RPN13;                   
COMPND 162 CHAIN: X;                                                            
COMPND 163 SYNONYM: RPN13, PROTEASOME NON-ATPASE SUBUNIT 13;                    
COMPND 164 MOL_ID: 32;                                                          
COMPND 165 MOLECULE: 26S PROTEASOME COMPLEX SUBUNIT SEM1;                       
COMPND 166 CHAIN: Y;                                                            
COMPND 167 FRAGMENT: SEM1;                                                      
COMPND 168 MOL_ID: 33;                                                          
COMPND 169 MOLECULE: 26S PROTEASOME REGULATORY SUBUNIT RPN1;                    
COMPND 170 CHAIN: Z;                                                            
COMPND 171 SYNONYM: HMG-COA REDUCTASE DEGRADATION PROTEIN 2, PROTEASOME NON-    
COMPND 172 ATPASE SUBUNIT 1                                                     
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE   3 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE   4 ORGANISM_TAXID: 4932;                                                
SOURCE   5 MOL_ID: 2;                                                           
SOURCE   6 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE   7 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE   8 ORGANISM_TAXID: 4932;                                                
SOURCE   9 MOL_ID: 3;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  11 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  12 ORGANISM_TAXID: 4932;                                                
SOURCE  13 MOL_ID: 4;                                                           
SOURCE  14 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  15 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  16 ORGANISM_TAXID: 4932;                                                
SOURCE  17 MOL_ID: 5;                                                           
SOURCE  18 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  19 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  20 ORGANISM_TAXID: 4932;                                                
SOURCE  21 MOL_ID: 6;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  23 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  24 ORGANISM_TAXID: 4932;                                                
SOURCE  25 MOL_ID: 7;                                                           
SOURCE  26 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  27 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  28 ORGANISM_TAXID: 4932;                                                
SOURCE  29 MOL_ID: 8;                                                           
SOURCE  30 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  31 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  32 ORGANISM_TAXID: 4932;                                                
SOURCE  33 MOL_ID: 9;                                                           
SOURCE  34 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  35 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  36 ORGANISM_TAXID: 4932;                                                
SOURCE  37 MOL_ID: 10;                                                          
SOURCE  38 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  39 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  40 ORGANISM_TAXID: 4932;                                                
SOURCE  41 MOL_ID: 11;                                                          
SOURCE  42 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  43 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  44 ORGANISM_TAXID: 4932;                                                
SOURCE  45 MOL_ID: 12;                                                          
SOURCE  46 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  47 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  48 ORGANISM_TAXID: 4932;                                                
SOURCE  49 MOL_ID: 13;                                                          
SOURCE  50 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  51 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  52 ORGANISM_TAXID: 4932;                                                
SOURCE  53 MOL_ID: 14;                                                          
SOURCE  54 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  55 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  56 ORGANISM_TAXID: 4932;                                                
SOURCE  57 MOL_ID: 15;                                                          
SOURCE  58 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  59 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  60 ORGANISM_TAXID: 4932;                                                
SOURCE  61 MOL_ID: 16;                                                          
SOURCE  62 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  63 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  64 ORGANISM_TAXID: 4932;                                                
SOURCE  65 MOL_ID: 17;                                                          
SOURCE  66 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  67 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  68 ORGANISM_TAXID: 4932;                                                
SOURCE  69 MOL_ID: 18;                                                          
SOURCE  70 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  71 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  72 ORGANISM_TAXID: 4932;                                                
SOURCE  73 MOL_ID: 19;                                                          
SOURCE  74 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  75 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  76 ORGANISM_TAXID: 4932;                                                
SOURCE  77 MOL_ID: 20;                                                          
SOURCE  78 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  79 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  80 ORGANISM_TAXID: 4932;                                                
SOURCE  81 MOL_ID: 21;                                                          
SOURCE  82 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  83 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  84 ORGANISM_TAXID: 4932;                                                
SOURCE  85 MOL_ID: 22;                                                          
SOURCE  86 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  87 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  88 ORGANISM_TAXID: 4932;                                                
SOURCE  89 MOL_ID: 23;                                                          
SOURCE  90 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  91 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  92 ORGANISM_TAXID: 4932;                                                
SOURCE  93 MOL_ID: 24;                                                          
SOURCE  94 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  95 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  96 ORGANISM_TAXID: 4932;                                                
SOURCE  97 MOL_ID: 25;                                                          
SOURCE  98 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE  99 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 100 ORGANISM_TAXID: 4932;                                                
SOURCE 101 MOL_ID: 26;                                                          
SOURCE 102 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 103 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 104 ORGANISM_TAXID: 4932;                                                
SOURCE 105 MOL_ID: 27;                                                          
SOURCE 106 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 107 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 108 ORGANISM_TAXID: 4932;                                                
SOURCE 109 MOL_ID: 28;                                                          
SOURCE 110 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 111 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 112 ORGANISM_TAXID: 4932;                                                
SOURCE 113 MOL_ID: 29;                                                          
SOURCE 114 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 115 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 116 ORGANISM_TAXID: 4932;                                                
SOURCE 117 MOL_ID: 30;                                                          
SOURCE 118 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 119 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 120 ORGANISM_TAXID: 4932;                                                
SOURCE 121 MOL_ID: 31;                                                          
SOURCE 122 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 123 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 124 ORGANISM_TAXID: 4932;                                                
SOURCE 125 MOL_ID: 32;                                                          
SOURCE 126 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 127 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 128 ORGANISM_TAXID: 4932;                                                
SOURCE 129 MOL_ID: 33;                                                          
SOURCE 130 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE;                       
SOURCE 131 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE 132 ORGANISM_TAXID: 4932                                                 
KEYWDS    HYDROLASE, AAA-ATPASE, ATP-ANALOG, CLASSIFICATION                     
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    P.UNVERDORBEN,F.BECK,P.SLEDZ,A.SCHWEITZER,G.PFEIFER,J.M.PLITZKO,      
AUTHOR   2 W.BAUMEISTER,F.FOERSTER                                              
REVDAT   5   03-OCT-18 4CR3    1       REMARK                                   
REVDAT   4   30-AUG-17 4CR3    1       REMARK                                   
REVDAT   3   30-APR-14 4CR3    1       JRNL                                     
REVDAT   2   16-APR-14 4CR3    1       JRNL                                     
REVDAT   1   02-APR-14 4CR3    0                                                
JRNL        AUTH   P.UNVERDORBEN,F.BECK,P.SLEDZ,A.SCHWEITZER,G.PFEIFER,         
JRNL        AUTH 2 J.M.PLITZKO,W.BAUMEISTER,F.FORSTER                           
JRNL        TITL   DEEP CLASSIFICATION OF A LARGE CRYO-EM DATASET DEFINES THE   
JRNL        TITL 2 CONFORMATIONAL LANDSCAPE OF THE 26S PROTEASOME.              
JRNL        REF    PROC.NATL.ACAD.SCI.USA        V. 111  5544 2014              
JRNL        REFN                   ISSN 0027-8424                               
JRNL        PMID   24706844                                                     
JRNL        DOI    10.1073/PNAS.1403409111                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    9.30 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : XMIPP                                     
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : FLEXIBLE FIT                        
REMARK   3   REFINEMENT TARGET            : FSC                                 
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : METHOD--MDFF                                     
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : 1.990                          
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 9.300                          
REMARK   3   NUMBER OF PARTICLES               : 300000                         
REMARK   3   CTF CORRECTION METHOD             : NULL                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: FITTING OF 20S XTAL     
REMARK   3  STRUCTURE                                                           
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: SUBMISSION BASED ON EXPERIMENTAL DATA FROM EMDB EMD   
REMARK   3  -2595 (DEPOSITION ID: 12357).                                       
REMARK   4                                                                      
REMARK   4 4CR3 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE.                               
REMARK 100 THE DEPOSITION ID IS D_1290059822.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : VITREOUS ICE                      
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : 26S PROTEASOME                    
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.30                              
REMARK 245   SAMPLE SUPPORT DETAILS         : HOLEY CARBON                      
REMARK 245   SAMPLE VITRIFICATION DETAILS   : VITRIFICATION 1 -- CRYOGEN-       
REMARK 245                                    ETHANE, INSTRUMENT- HOMEMADE      
REMARK 245                                    PLUNGER,                          
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.10                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : 24-DEC-13                      
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : 80.50                          
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : TVIPS TEMCAM-F816 (8K X 8K)    
REMARK 245   MINIMUM DEFOCUS (NM)              : 1000.00                        
REMARK 245   MAXIMUM DEFOCUS (NM)              : 3500.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : 0.00                           
REMARK 245   NOMINAL CS                        : 2.00                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 25.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 200                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 33-MERIC                          
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 33-MERIC                   
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: 1, 2, 3, 4, 5, 6, 7, A, B, C,         
REMARK 350                    AND CHAINS: D, E, F, G, H, I, J, K, L,            
REMARK 350                    AND CHAINS: M, N, O, P, Q, R, S, T, U, V,         
REMARK 350                    AND CHAINS: W, X, Y, Z                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET 1   -19                                                      
REMARK 465     ASN 1   -18                                                      
REMARK 465     GLY 1   -17                                                      
REMARK 465     ILE 1   -16                                                      
REMARK 465     GLN 1   -15                                                      
REMARK 465     VAL 1   -14                                                      
REMARK 465     ASP 1   -13                                                      
REMARK 465     ILE 1   -12                                                      
REMARK 465     ASN 1   -11                                                      
REMARK 465     ARG 1   -10                                                      
REMARK 465     MET 2   -28                                                      
REMARK 465     ALA 2   -27                                                      
REMARK 465     GLY 2   -26                                                      
REMARK 465     LEU 2   -25                                                      
REMARK 465     SER 2   -24                                                      
REMARK 465     PHE 2   -23                                                      
REMARK 465     ASP 2   -22                                                      
REMARK 465     ASN 2   -21                                                      
REMARK 465     TYR 2   -20                                                      
REMARK 465     GLN 2   -19                                                      
REMARK 465     ARG 2   -18                                                      
REMARK 465     ASN 2   -17                                                      
REMARK 465     ASN 2   -16                                                      
REMARK 465     PHE 2   -15                                                      
REMARK 465     LEU 2   -14                                                      
REMARK 465     ALA 2   -13                                                      
REMARK 465     GLU 2   -12                                                      
REMARK 465     ASN 2   -11                                                      
REMARK 465     SER 2   -10                                                      
REMARK 465     HIS 2    -9                                                      
REMARK 465     THR 2    -8                                                      
REMARK 465     GLN 2    -7                                                      
REMARK 465     PRO 2    -6                                                      
REMARK 465     LYS 2    -5                                                      
REMARK 465     ALA 2    -4                                                      
REMARK 465     THR 2    -3                                                      
REMARK 465     SER 2    -2                                                      
REMARK 465     THR 2    -1                                                      
REMARK 465     GLY 2     0                                                      
REMARK 465     GLN 2   224                                                      
REMARK 465     GLU 2   225                                                      
REMARK 465     GLU 2   226                                                      
REMARK 465     GLN 2   227                                                      
REMARK 465     VAL 2   228                                                      
REMARK 465     ASP 2   229                                                      
REMARK 465     ILE 2   230                                                      
REMARK 465     THR 2   231                                                      
REMARK 465     ALA 2   232                                                      
REMARK 465     MET 3    -9                                                      
REMARK 465     MET 5   -74                                                      
REMARK 465     GLN 5   -73                                                      
REMARK 465     ALA 5   -72                                                      
REMARK 465     ILE 5   -71                                                      
REMARK 465     ALA 5   -70                                                      
REMARK 465     ASP 5   -69                                                      
REMARK 465     SER 5   -68                                                      
REMARK 465     PHE 5   -67                                                      
REMARK 465     SER 5   -66                                                      
REMARK 465     VAL 5   -65                                                      
REMARK 465     PRO 5   -64                                                      
REMARK 465     ASN 5   -63                                                      
REMARK 465     ARG 5   -62                                                      
REMARK 465     LEU 5   -61                                                      
REMARK 465     VAL 5   -60                                                      
REMARK 465     LYS 5   -59                                                      
REMARK 465     GLU 5   -58                                                      
REMARK 465     LEU 5   -57                                                      
REMARK 465     GLN 5   -56                                                      
REMARK 465     TYR 5   -55                                                      
REMARK 465     ASP 5   -54                                                      
REMARK 465     ASN 5   -53                                                      
REMARK 465     GLU 5   -52                                                      
REMARK 465     GLN 5   -51                                                      
REMARK 465     ASN 5   -50                                                      
REMARK 465     LEU 5   -49                                                      
REMARK 465     GLU 5   -48                                                      
REMARK 465     SER 5   -47                                                      
REMARK 465     ASP 5   -46                                                      
REMARK 465     PHE 5   -45                                                      
REMARK 465     VAL 5   -44                                                      
REMARK 465     THR 5   -43                                                      
REMARK 465     GLY 5   -42                                                      
REMARK 465     ALA 5   -41                                                      
REMARK 465     SER 5   -40                                                      
REMARK 465     GLN 5   -39                                                      
REMARK 465     PHE 5   -38                                                      
REMARK 465     GLN 5   -37                                                      
REMARK 465     ARG 5   -36                                                      
REMARK 465     LEU 5   -35                                                      
REMARK 465     ALA 5   -34                                                      
REMARK 465     PRO 5   -33                                                      
REMARK 465     SER 5   -32                                                      
REMARK 465     LEU 5   -31                                                      
REMARK 465     THR 5   -30                                                      
REMARK 465     VAL 5   -29                                                      
REMARK 465     PRO 5   -28                                                      
REMARK 465     PRO 5   -27                                                      
REMARK 465     ILE 5   -26                                                      
REMARK 465     ALA 5   -25                                                      
REMARK 465     SER 5   -24                                                      
REMARK 465     PRO 5   -23                                                      
REMARK 465     GLN 5   -22                                                      
REMARK 465     GLN 5   -21                                                      
REMARK 465     PHE 5   -20                                                      
REMARK 465     LEU 5   -19                                                      
REMARK 465     ARG 5   -18                                                      
REMARK 465     ALA 5   -17                                                      
REMARK 465     HIS 5   -16                                                      
REMARK 465     THR 5   -15                                                      
REMARK 465     ASP 5   -14                                                      
REMARK 465     ASP 5   -13                                                      
REMARK 465     SER 5   -12                                                      
REMARK 465     ARG 5   -11                                                      
REMARK 465     ASN 5   -10                                                      
REMARK 465     PRO 5    -9                                                      
REMARK 465     ASP 5    -8                                                      
REMARK 465     CYS 5    -7                                                      
REMARK 465     LYS 5    -6                                                      
REMARK 465     ILE 5    -5                                                      
REMARK 465     LYS 5    -4                                                      
REMARK 465     ILE 5    -3                                                      
REMARK 465     ALA 5    -2                                                      
REMARK 465     HIS 5    -1                                                      
REMARK 465     GLY 5     0                                                      
REMARK 465     MET 6   -28                                                      
REMARK 465     ALA 6   -27                                                      
REMARK 465     THR 6   -26                                                      
REMARK 465     ILE 6   -25                                                      
REMARK 465     ALA 6   -24                                                      
REMARK 465     SER 6   -23                                                      
REMARK 465     GLU 6   -22                                                      
REMARK 465     TYR 6   -21                                                      
REMARK 465     SER 6   -20                                                      
REMARK 465     SER 6   -19                                                      
REMARK 465     GLU 6   -18                                                      
REMARK 465     ALA 6   -17                                                      
REMARK 465     SER 6   -16                                                      
REMARK 465     ASN 6   -15                                                      
REMARK 465     THR 6   -14                                                      
REMARK 465     PRO 6   -13                                                      
REMARK 465     ILE 6   -12                                                      
REMARK 465     GLU 6   -11                                                      
REMARK 465     HIS 6   -10                                                      
REMARK 465     MET 7   -41                                                      
REMARK 465     ASN 7   -40                                                      
REMARK 465     HIS 7   -39                                                      
REMARK 465     ASP 7   -38                                                      
REMARK 465     PRO 7   -37                                                      
REMARK 465     PHE 7   -36                                                      
REMARK 465     SER 7   -35                                                      
REMARK 465     TRP 7   -34                                                      
REMARK 465     GLY 7   -33                                                      
REMARK 465     ARG 7   -32                                                      
REMARK 465     PRO 7   -31                                                      
REMARK 465     ALA 7   -30                                                      
REMARK 465     ASP 7   -29                                                      
REMARK 465     SER 7   -28                                                      
REMARK 465     THR 7   -27                                                      
REMARK 465     TYR 7   -26                                                      
REMARK 465     GLY 7   -25                                                      
REMARK 465     ALA 7   -24                                                      
REMARK 465     TYR 7   -23                                                      
REMARK 465     ASN 7   -22                                                      
REMARK 465     THR 7   -21                                                      
REMARK 465     GLN 7   -20                                                      
REMARK 465     ILE 7   -19                                                      
REMARK 465     ALA 7   -18                                                      
REMARK 465     ASN 7   -17                                                      
REMARK 465     ALA 7   -16                                                      
REMARK 465     GLY 7   -15                                                      
REMARK 465     ALA 7   -14                                                      
REMARK 465     SER 7   -13                                                      
REMARK 465     PRO 7   -12                                                      
REMARK 465     MET 7   -11                                                      
REMARK 465     VAL 7   -10                                                      
REMARK 465     ASN 7    -9                                                      
REMARK 465     MET A     1                                                      
REMARK 465     SER A     2                                                      
REMARK 465     GLY A     3                                                      
REMARK 465     ALA A     4                                                      
REMARK 465     ALA A     5                                                      
REMARK 465     ALA A     6                                                      
REMARK 465     ALA A     7                                                      
REMARK 465     SER A     8                                                      
REMARK 465     ALA A     9                                                      
REMARK 465     MET C     1                                                      
REMARK 465     LYS C   247                                                      
REMARK 465     ASP C   248                                                      
REMARK 465     GLU C   249                                                      
REMARK 465     ASP C   250                                                      
REMARK 465     GLU C   251                                                      
REMARK 465     GLU C   252                                                      
REMARK 465     ALA C   253                                                      
REMARK 465     ASP C   254                                                      
REMARK 465     GLU C   255                                                      
REMARK 465     ASP C   256                                                      
REMARK 465     MET C   257                                                      
REMARK 465     LYS C   258                                                      
REMARK 465     MET D     1                                                      
REMARK 465     SER D     2                                                      
REMARK 465     GLU D   245                                                      
REMARK 465     GLN D   246                                                      
REMARK 465     ASP D   247                                                      
REMARK 465     LYS D   248                                                      
REMARK 465     LYS D   249                                                      
REMARK 465     LYS D   250                                                      
REMARK 465     LYS D   251                                                      
REMARK 465     SER D   252                                                      
REMARK 465     ASN D   253                                                      
REMARK 465     HIS D   254                                                      
REMARK 465     MET E     1                                                      
REMARK 465     PHE E     2                                                      
REMARK 465     LEU E     3                                                      
REMARK 465     THR E     4                                                      
REMARK 465     ARG E     5                                                      
REMARK 465     SER E     6                                                      
REMARK 465     GLU E     7                                                      
REMARK 465     TYR E     8                                                      
REMARK 465     PRO E   252                                                      
REMARK 465     GLU E   253                                                      
REMARK 465     GLU E   254                                                      
REMARK 465     ALA E   255                                                      
REMARK 465     ASP E   256                                                      
REMARK 465     VAL E   257                                                      
REMARK 465     GLU E   258                                                      
REMARK 465     MET E   259                                                      
REMARK 465     SER E   260                                                      
REMARK 465     MET F     1                                                      
REMARK 465     MET G     0                                                      
REMARK 465     THR G     1                                                      
REMARK 465     SER G     2                                                      
REMARK 465     ILE G     3                                                      
REMARK 465     ASP G   249                                                      
REMARK 465     ASP G   250                                                      
REMARK 465     ASP G   251                                                      
REMARK 465     GLU G   252                                                      
REMARK 465     ASP G   253                                                      
REMARK 465     GLU G   254                                                      
REMARK 465     ASP G   255                                                      
REMARK 465     ASP G   256                                                      
REMARK 465     SER G   257                                                      
REMARK 465     ASP G   258                                                      
REMARK 465     ASN G   259                                                      
REMARK 465     VAL G   260                                                      
REMARK 465     MET G   261                                                      
REMARK 465     SER G   262                                                      
REMARK 465     SER G   263                                                      
REMARK 465     ASP G   264                                                      
REMARK 465     ASP G   265                                                      
REMARK 465     GLU G   266                                                      
REMARK 465     ASN G   267                                                      
REMARK 465     ALA G   268                                                      
REMARK 465     PRO G   269                                                      
REMARK 465     VAL G   270                                                      
REMARK 465     ALA G   271                                                      
REMARK 465     THR G   272                                                      
REMARK 465     ASN G   273                                                      
REMARK 465     ALA G   274                                                      
REMARK 465     ASN G   275                                                      
REMARK 465     ALA G   276                                                      
REMARK 465     THR G   277                                                      
REMARK 465     THR G   278                                                      
REMARK 465     ASP G   279                                                      
REMARK 465     GLN G   280                                                      
REMARK 465     GLU G   281                                                      
REMARK 465     GLY G   282                                                      
REMARK 465     ASP G   283                                                      
REMARK 465     ILE G   284                                                      
REMARK 465     HIS G   285                                                      
REMARK 465     LEU G   286                                                      
REMARK 465     GLU G   287                                                      
REMARK 465     MET H     1                                                      
REMARK 465     PRO H     2                                                      
REMARK 465     PRO H     3                                                      
REMARK 465     LYS H     4                                                      
REMARK 465     GLU H     5                                                      
REMARK 465     ASP H     6                                                      
REMARK 465     TRP H     7                                                      
REMARK 465     GLU H     8                                                      
REMARK 465     LYS H     9                                                      
REMARK 465     TYR H    10                                                      
REMARK 465     LYS H    11                                                      
REMARK 465     ALA H    12                                                      
REMARK 465     PRO H    13                                                      
REMARK 465     LEU H    14                                                      
REMARK 465     GLU H    15                                                      
REMARK 465     ASP H    16                                                      
REMARK 465     ASP H    17                                                      
REMARK 465     ASP H    18                                                      
REMARK 465     LYS H    19                                                      
REMARK 465     LYS H    20                                                      
REMARK 465     PRO H    21                                                      
REMARK 465     ASP H    22                                                      
REMARK 465     ASP H    23                                                      
REMARK 465     ASP H    24                                                      
REMARK 465     LYS H    25                                                      
REMARK 465     ILE H    26                                                      
REMARK 465     VAL H    27                                                      
REMARK 465     PRO H    28                                                      
REMARK 465     LEU H    29                                                      
REMARK 465     THR H    30                                                      
REMARK 465     GLU H    31                                                      
REMARK 465     GLY H    32                                                      
REMARK 465     ASP H    33                                                      
REMARK 465     ILE H    34                                                      
REMARK 465     GLN H    35                                                      
REMARK 465     VAL H    36                                                      
REMARK 465     LEU H    37                                                      
REMARK 465     LYS H    38                                                      
REMARK 465     SER H    39                                                      
REMARK 465     TYR H    40                                                      
REMARK 465     GLY H    41                                                      
REMARK 465     ALA H    42                                                      
REMARK 465     ALA H    43                                                      
REMARK 465     PRO H    44                                                      
REMARK 465     TYR H    45                                                      
REMARK 465     ALA H    46                                                      
REMARK 465     ALA H    47                                                      
REMARK 465     LYS H    48                                                      
REMARK 465     PRO H    78                                                      
REMARK 465     SER H    79                                                      
REMARK 465     HIS H    80                                                      
REMARK 465     LEU H    81                                                      
REMARK 465     TRP H    82                                                      
REMARK 465     ASP H    83                                                      
REMARK 465     ILE H    84                                                      
REMARK 465     MET H    85                                                      
REMARK 465     GLY H    86                                                      
REMARK 465     ASP H    87                                                      
REMARK 465     ARG H    88                                                      
REMARK 465     GLN H    89                                                      
REMARK 465     ARG H    90                                                      
REMARK 465     LEU H    91                                                      
REMARK 465     GLY H    92                                                      
REMARK 465     GLU H    93                                                      
REMARK 465     GLU H    94                                                      
REMARK 465     ASN H   109                                                      
REMARK 465     GLY H   110                                                      
REMARK 465     GLU H   111                                                      
REMARK 465     SER H   112                                                      
REMARK 465     ASP H   113                                                      
REMARK 465     GLU H   114                                                      
REMARK 465     THR H   115                                                      
REMARK 465     THR H   116                                                      
REMARK 465     THR H   117                                                      
REMARK 465     ASP H   118                                                      
REMARK 465     ASN H   119                                                      
REMARK 465     ASN H   120                                                      
REMARK 465     ASN H   121                                                      
REMARK 465     SER H   122                                                      
REMARK 465     GLY H   123                                                      
REMARK 465     ASN H   124                                                      
REMARK 465     SER H   125                                                      
REMARK 465     ASN H   126                                                      
REMARK 465     SER H   127                                                      
REMARK 465     ASN H   128                                                      
REMARK 465     SER H   129                                                      
REMARK 465     ASN H   130                                                      
REMARK 465     GLN H   131                                                      
REMARK 465     GLN H   132                                                      
REMARK 465     SER H   133                                                      
REMARK 465     THR H   134                                                      
REMARK 465     ASP H   135                                                      
REMARK 465     ALA H   136                                                      
REMARK 465     ASP H   137                                                      
REMARK 465     GLU H   138                                                      
REMARK 465     ASP H   139                                                      
REMARK 465     ASP H   140                                                      
REMARK 465     PHE H   457                                                      
REMARK 465     SER H   458                                                      
REMARK 465     SER H   459                                                      
REMARK 465     THR H   460                                                      
REMARK 465     SER H   461                                                      
REMARK 465     ARG H   462                                                      
REMARK 465     TYR H   463                                                      
REMARK 465     MET H   464                                                      
REMARK 465     GLN H   465                                                      
REMARK 465     TYR H   466                                                      
REMARK 465     ASN H   467                                                      
REMARK 465     MET I     1                                                      
REMARK 465     GLY I     2                                                      
REMARK 465     GLN I     3                                                      
REMARK 465     GLY I     4                                                      
REMARK 465     VAL I     5                                                      
REMARK 465     SER I     6                                                      
REMARK 465     SER I     7                                                      
REMARK 465     GLY I     8                                                      
REMARK 465     GLN I     9                                                      
REMARK 465     ASP I    10                                                      
REMARK 465     LYS I    11                                                      
REMARK 465     LYS I    12                                                      
REMARK 465     LYS I    13                                                      
REMARK 465     LYS I    14                                                      
REMARK 465     LYS I    15                                                      
REMARK 465     GLY I    16                                                      
REMARK 465     SER I    17                                                      
REMARK 465     ASN I    18                                                      
REMARK 465     GLN I    19                                                      
REMARK 465     LYS I    20                                                      
REMARK 465     PRO I    21                                                      
REMARK 465     LYS I    22                                                      
REMARK 465     TYR I    23                                                      
REMARK 465     GLU I    24                                                      
REMARK 465     PRO I    25                                                      
REMARK 465     PRO I    26                                                      
REMARK 465     VAL I    27                                                      
REMARK 465     GLN I    28                                                      
REMARK 465     SER I    29                                                      
REMARK 465     LYS I    30                                                      
REMARK 465     PHE I    31                                                      
REMARK 465     GLY I    32                                                      
REMARK 465     ARG I    33                                                      
REMARK 465     LYS I    34                                                      
REMARK 465     LYS I    35                                                      
REMARK 465     ARG I    36                                                      
REMARK 465     LYS I    37                                                      
REMARK 465     GLY I    38                                                      
REMARK 465     GLY I    39                                                      
REMARK 465     PRO I    40                                                      
REMARK 465     ALA I    41                                                      
REMARK 465     THR I    42                                                      
REMARK 465     ALA I    43                                                      
REMARK 465     GLU I    44                                                      
REMARK 465     LYS I    45                                                      
REMARK 465     LEU I    46                                                      
REMARK 465     PRO I    47                                                      
REMARK 465     ASN I    48                                                      
REMARK 465     ILE I    49                                                      
REMARK 465     TYR I    50                                                      
REMARK 465     PRO I    51                                                      
REMARK 465     SER I    52                                                      
REMARK 465     THR I    53                                                      
REMARK 465     ARG I    54                                                      
REMARK 465     CYS I    55                                                      
REMARK 465     LYS I    56                                                      
REMARK 465     LEU I    57                                                      
REMARK 465     LYS I    58                                                      
REMARK 465     LEU I    59                                                      
REMARK 465     LEU I    60                                                      
REMARK 465     ARG I    61                                                      
REMARK 465     MET I    62                                                      
REMARK 465     GLU I    63                                                      
REMARK 465     ARG I    64                                                      
REMARK 465     ILE I    65                                                      
REMARK 465     LYS I    66                                                      
REMARK 465     ASP I    67                                                      
REMARK 465     HIS I    68                                                      
REMARK 465     LEU I    69                                                      
REMARK 465     LEU I    70                                                      
REMARK 465     LEU I    71                                                      
REMARK 465     GLU I    72                                                      
REMARK 465     GLU I    73                                                      
REMARK 465     GLU I    74                                                      
REMARK 465     LEU I   437                                                      
REMARK 465     MET J     1                                                      
REMARK 465     THR J     2                                                      
REMARK 465     ALA J     3                                                      
REMARK 465     ALA J     4                                                      
REMARK 465     VAL J     5                                                      
REMARK 465     THR J     6                                                      
REMARK 465     SER J     7                                                      
REMARK 465     SER J     8                                                      
REMARK 465     ASN J     9                                                      
REMARK 465     ILE J    10                                                      
REMARK 465     VAL J    11                                                      
REMARK 465     LEU J    12                                                      
REMARK 465     GLU J    13                                                      
REMARK 465     THR J    14                                                      
REMARK 465     HIS J    15                                                      
REMARK 465     GLU J    16                                                      
REMARK 465     SER J    17                                                      
REMARK 465     GLY J    18                                                      
REMARK 465     ILE J    19                                                      
REMARK 465     LYS J    20                                                      
REMARK 465     PRO J    21                                                      
REMARK 465     TYR J    22                                                      
REMARK 465     PHE J    23                                                      
REMARK 465     ALA J   397                                                      
REMARK 465     ILE J   398                                                      
REMARK 465     SER J   399                                                      
REMARK 465     VAL J   400                                                      
REMARK 465     ALA J   401                                                      
REMARK 465     LYS J   402                                                      
REMARK 465     LEU J   403                                                      
REMARK 465     PHE J   404                                                      
REMARK 465     LYS J   405                                                      
REMARK 465     MET K     1                                                      
REMARK 465     GLU K     2                                                      
REMARK 465     GLU K     3                                                      
REMARK 465     LEU K     4                                                      
REMARK 465     GLY K     5                                                      
REMARK 465     ILE K     6                                                      
REMARK 465     VAL K     7                                                      
REMARK 465     THR K     8                                                      
REMARK 465     PRO K     9                                                      
REMARK 465     VAL K    10                                                      
REMARK 465     GLU K    11                                                      
REMARK 465     LYS K    12                                                      
REMARK 465     ALA K    13                                                      
REMARK 465     VAL K    14                                                      
REMARK 465     GLU K    15                                                      
REMARK 465     GLU K    16                                                      
REMARK 465     LYS K    17                                                      
REMARK 465     PRO K    18                                                      
REMARK 465     ALA K    19                                                      
REMARK 465     VAL K    20                                                      
REMARK 465     LYS K    21                                                      
REMARK 465     SER K    22                                                      
REMARK 465     TYR K    23                                                      
REMARK 465     ALA K    24                                                      
REMARK 465     SER K    25                                                      
REMARK 465     LEU K    26                                                      
REMARK 465     LEU K    27                                                      
REMARK 465     ALA K    28                                                      
REMARK 465     GLN K    29                                                      
REMARK 465     LEU K    30                                                      
REMARK 465     ASN K    31                                                      
REMARK 465     GLY K    32                                                      
REMARK 465     THR K    33                                                      
REMARK 465     VAL K    34                                                      
REMARK 465     ASN K    35                                                      
REMARK 465     ASN K    36                                                      
REMARK 465     ASN K    37                                                      
REMARK 465     SER K    38                                                      
REMARK 465     ALA K    39                                                      
REMARK 465     LEU K    40                                                      
REMARK 465     SER K    41                                                      
REMARK 465     ASN K    42                                                      
REMARK 465     VAL K    43                                                      
REMARK 465     ASN K    44                                                      
REMARK 465     SER K    45                                                      
REMARK 465     ASP K    46                                                      
REMARK 465     ILE K    47                                                      
REMARK 465     MET L     1                                                      
REMARK 465     SER L     2                                                      
REMARK 465     GLU L     3                                                      
REMARK 465     GLU L     4                                                      
REMARK 465     GLN L     5                                                      
REMARK 465     ASP L     6                                                      
REMARK 465     PRO L     7                                                      
REMARK 465     LEU L     8                                                      
REMARK 465     LEU L     9                                                      
REMARK 465     ALA L    10                                                      
REMARK 465     GLY L    11                                                      
REMARK 465     LEU L    12                                                      
REMARK 465     GLY L    13                                                      
REMARK 465     GLU L    14                                                      
REMARK 465     THR L    15                                                      
REMARK 465     SER L    16                                                      
REMARK 465     GLY L    17                                                      
REMARK 465     ASP L    18                                                      
REMARK 465     ASN L    19                                                      
REMARK 465     HIS L    20                                                      
REMARK 465     THR L    21                                                      
REMARK 465     GLN L    22                                                      
REMARK 465     GLN L    23                                                      
REMARK 465     SER L    24                                                      
REMARK 465     HIS L    25                                                      
REMARK 465     GLU L    26                                                      
REMARK 465     GLN L    27                                                      
REMARK 465     GLN L    28                                                      
REMARK 465     PRO L    29                                                      
REMARK 465     GLU L    30                                                      
REMARK 465     GLN L    31                                                      
REMARK 465     PRO L    32                                                      
REMARK 465     GLN L    33                                                      
REMARK 465     GLU L    34                                                      
REMARK 465     THR L    35                                                      
REMARK 465     GLU L    36                                                      
REMARK 465     GLU L    37                                                      
REMARK 465     HIS L    38                                                      
REMARK 465     HIS L    39                                                      
REMARK 465     GLU L    40                                                      
REMARK 465     GLU L    41                                                      
REMARK 465     GLU L    42                                                      
REMARK 465     PRO L    43                                                      
REMARK 465     SER L    44                                                      
REMARK 465     ARG L    45                                                      
REMARK 465     VAL L    46                                                      
REMARK 465     ASP L    47                                                      
REMARK 465     PRO L    48                                                      
REMARK 465     GLU L    49                                                      
REMARK 465     GLN L    50                                                      
REMARK 465     GLU L    51                                                      
REMARK 465     ALA L    52                                                      
REMARK 465     HIS L    53                                                      
REMARK 465     ASN L    54                                                      
REMARK 465     LYS L    55                                                      
REMARK 465     ALA L    56                                                      
REMARK 465     LEU L    57                                                      
REMARK 465     ASN L    58                                                      
REMARK 465     GLN L    59                                                      
REMARK 465     PHE L    60                                                      
REMARK 465     LYS L    61                                                      
REMARK 465     ARG L    62                                                      
REMARK 465     LYS L    63                                                      
REMARK 465     LEU L    64                                                      
REMARK 465     LEU L    65                                                      
REMARK 465     GLU L    66                                                      
REMARK 465     LEU L   428                                                      
REMARK 465     GLU L   429                                                      
REMARK 465     GLY L   430                                                      
REMARK 465     THR L   431                                                      
REMARK 465     ILE L   432                                                      
REMARK 465     GLU L   433                                                      
REMARK 465     TYR L   434                                                      
REMARK 465     GLN L   435                                                      
REMARK 465     LYS L   436                                                      
REMARK 465     LEU L   437                                                      
REMARK 465     MET M     1                                                      
REMARK 465     ALA M     2                                                      
REMARK 465     THR M     3                                                      
REMARK 465     LEU M     4                                                      
REMARK 465     GLU M     5                                                      
REMARK 465     GLU M     6                                                      
REMARK 465     LEU M     7                                                      
REMARK 465     ASP M     8                                                      
REMARK 465     ALA M     9                                                      
REMARK 465     GLN M    10                                                      
REMARK 465     THR M    11                                                      
REMARK 465     LEU M    12                                                      
REMARK 465     PRO M    13                                                      
REMARK 465     GLY M    14                                                      
REMARK 465     ASP M    15                                                      
REMARK 465     ASP M    16                                                      
REMARK 465     GLU M    17                                                      
REMARK 465     LEU M    18                                                      
REMARK 465     ASP M    19                                                      
REMARK 465     GLN M    20                                                      
REMARK 465     GLU M    21                                                      
REMARK 465     ILE M    22                                                      
REMARK 465     LEU M    23                                                      
REMARK 465     ASN M    24                                                      
REMARK 465     LEU M    25                                                      
REMARK 465     SER M    26                                                      
REMARK 465     THR M    27                                                      
REMARK 465     GLN M    28                                                      
REMARK 465     GLU M    29                                                      
REMARK 465     LEU M    30                                                      
REMARK 465     GLN M    31                                                      
REMARK 465     THR M    32                                                      
REMARK 465     ARG M    33                                                      
REMARK 465     ALA M    34                                                      
REMARK 465     LYS M    35                                                      
REMARK 465     LEU M    36                                                      
REMARK 465     LEU M    37                                                      
REMARK 465     ASP M    38                                                      
REMARK 465     ASN M    39                                                      
REMARK 465     GLU M    40                                                      
REMARK 465     MET M    86                                                      
REMARK 465     ASP M    87                                                      
REMARK 465     MET M    88                                                      
REMARK 465     ASN M    89                                                      
REMARK 465     GLU M    90                                                      
REMARK 465     ILE M    91                                                      
REMARK 465     GLU M    92                                                      
REMARK 465     ASP M    93                                                      
REMARK 465     LYS M    94                                                      
REMARK 465     GLU M    95                                                      
REMARK 465     ASN M    96                                                      
REMARK 465     SER M    97                                                      
REMARK 465     GLU M    98                                                      
REMARK 465     SER M    99                                                      
REMARK 465     THR M   100                                                      
REMARK 465     THR M   101                                                      
REMARK 465     GLN M   102                                                      
REMARK 465     GLY M   103                                                      
REMARK 465     GLY M   104                                                      
REMARK 465     ASN M   105                                                      
REMARK 465     VAL M   106                                                      
REMARK 465     ASN M   107                                                      
REMARK 465     LEU M   108                                                      
REMARK 465     ASP M   109                                                      
REMARK 465     ASN M   110                                                      
REMARK 465     THR M   111                                                      
REMARK 465     ALA M   112                                                      
REMARK 465     MET N     1                                                      
REMARK 465     SER N     2                                                      
REMARK 465     LEU N     3                                                      
REMARK 465     ASP N   177                                                      
REMARK 465     TYR N   788                                                      
REMARK 465     GLU N   789                                                      
REMARK 465     GLU N   790                                                      
REMARK 465     ALA N   791                                                      
REMARK 465     SER N   792                                                      
REMARK 465     GLY N   793                                                      
REMARK 465     LYS N   794                                                      
REMARK 465     GLU N   795                                                      
REMARK 465     VAL N   796                                                      
REMARK 465     GLU N   797                                                      
REMARK 465     LYS N   798                                                      
REMARK 465     VAL N   799                                                      
REMARK 465     ALA N   800                                                      
REMARK 465     THR N   801                                                      
REMARK 465     ALA N   802                                                      
REMARK 465     VAL N   803                                                      
REMARK 465     LEU N   804                                                      
REMARK 465     SER N   805                                                      
REMARK 465     THR N   806                                                      
REMARK 465     THR N   807                                                      
REMARK 465     ALA N   808                                                      
REMARK 465     ARG N   809                                                      
REMARK 465     ALA N   810                                                      
REMARK 465     LYS N   811                                                      
REMARK 465     ALA N   812                                                      
REMARK 465     ARG N   813                                                      
REMARK 465     ALA N   814                                                      
REMARK 465     LYS N   815                                                      
REMARK 465     LYS N   816                                                      
REMARK 465     THR N   817                                                      
REMARK 465     LYS N   818                                                      
REMARK 465     LYS N   819                                                      
REMARK 465     GLU N   820                                                      
REMARK 465     LYS N   821                                                      
REMARK 465     GLY N   822                                                      
REMARK 465     PRO N   823                                                      
REMARK 465     ASN N   824                                                      
REMARK 465     GLU N   825                                                      
REMARK 465     GLU N   826                                                      
REMARK 465     GLU N   827                                                      
REMARK 465     LYS N   828                                                      
REMARK 465     LYS N   829                                                      
REMARK 465     LYS N   830                                                      
REMARK 465     GLU N   831                                                      
REMARK 465     HIS N   832                                                      
REMARK 465     GLU N   833                                                      
REMARK 465     GLU N   834                                                      
REMARK 465     LYS N   835                                                      
REMARK 465     GLU N   836                                                      
REMARK 465     LYS N   837                                                      
REMARK 465     GLU N   838                                                      
REMARK 465     ARG N   839                                                      
REMARK 465     GLU N   840                                                      
REMARK 465     THR N   841                                                      
REMARK 465     ASN N   842                                                      
REMARK 465     LYS N   843                                                      
REMARK 465     LYS N   844                                                      
REMARK 465     GLY N   845                                                      
REMARK 465     ILE N   846                                                      
REMARK 465     LYS N   847                                                      
REMARK 465     GLU N   848                                                      
REMARK 465     THR N   849                                                      
REMARK 465     LYS N   850                                                      
REMARK 465     GLU N   851                                                      
REMARK 465     ASN N   852                                                      
REMARK 465     ASP N   853                                                      
REMARK 465     GLU N   854                                                      
REMARK 465     GLU N   855                                                      
REMARK 465     PHE N   856                                                      
REMARK 465     TYR N   857                                                      
REMARK 465     LYS N   858                                                      
REMARK 465     ASN N   859                                                      
REMARK 465     VAL N   926                                                      
REMARK 465     ASN N   927                                                      
REMARK 465     ALA N   928                                                      
REMARK 465     PRO N   929                                                      
REMARK 465     LEU N   930                                                      
REMARK 465     PRO N   931                                                      
REMARK 465     THR N   932                                                      
REMARK 465     PRO N   933                                                      
REMARK 465     PHE N   934                                                      
REMARK 465     LYS N   935                                                      
REMARK 465     VAL N   936                                                      
REMARK 465     ASP N   937                                                      
REMARK 465     ASP N   938                                                      
REMARK 465     ASN N   939                                                      
REMARK 465     VAL N   940                                                      
REMARK 465     ASP N   941                                                      
REMARK 465     PHE N   942                                                      
REMARK 465     PRO N   943                                                      
REMARK 465     SER N   944                                                      
REMARK 465     ALA N   945                                                      
REMARK 465     GLY O   388                                                      
REMARK 465     GLN O   389                                                      
REMARK 465     SER O   390                                                      
REMARK 465     ILE O   391                                                      
REMARK 465     TRP O   392                                                      
REMARK 465     VAL O   393                                                      
REMARK 465     MET P     1                                                      
REMARK 465     SER P     2                                                      
REMARK 465     ARG P     3                                                      
REMARK 465     ASP P     4                                                      
REMARK 465     ALA P     5                                                      
REMARK 465     PRO P     6                                                      
REMARK 465     ILE P     7                                                      
REMARK 465     LYS P     8                                                      
REMARK 465     ALA P     9                                                      
REMARK 465     ASP P    10                                                      
REMARK 465     LYS P    11                                                      
REMARK 465     ASP P    12                                                      
REMARK 465     TYR P    13                                                      
REMARK 465     SER P    14                                                      
REMARK 465     GLN P    15                                                      
REMARK 465     ILE P    16                                                      
REMARK 465     LEU P    17                                                      
REMARK 465     LYS P    18                                                      
REMARK 465     GLU P    19                                                      
REMARK 465     GLU P    20                                                      
REMARK 465     PHE P    21                                                      
REMARK 465     PRO P    22                                                      
REMARK 465     LYS P    23                                                      
REMARK 465     ILE P    24                                                      
REMARK 465     ASP P    25                                                      
REMARK 465     SER P    26                                                      
REMARK 465     LEU P    27                                                      
REMARK 465     GLN P   443                                                      
REMARK 465     ALA P   444                                                      
REMARK 465     LYS P   445                                                      
REMARK 465     VAL Q   432                                                      
REMARK 465     LEU Q   433                                                      
REMARK 465     TYR Q   434                                                      
REMARK 465     MET R     1                                                      
REMARK 465     VAL R     2                                                      
REMARK 465     ASP R     3                                                      
REMARK 465     VAL R     4                                                      
REMARK 465     GLU R     5                                                      
REMARK 465     GLU R     6                                                      
REMARK 465     LYS R     7                                                      
REMARK 465     SER R     8                                                      
REMARK 465     GLN R     9                                                      
REMARK 465     GLU R    10                                                      
REMARK 465     VAL R    11                                                      
REMARK 465     GLU R    12                                                      
REMARK 465     TYR R    13                                                      
REMARK 465     VAL R    14                                                      
REMARK 465     ASP R    15                                                      
REMARK 465     PRO R    16                                                      
REMARK 465     THR R    17                                                      
REMARK 465     VAL R    18                                                      
REMARK 465     ASN R    19                                                      
REMARK 465     ARG R    20                                                      
REMARK 465     VAL R    21                                                      
REMARK 465     PRO R    22                                                      
REMARK 465     LEU R   423                                                      
REMARK 465     THR R   424                                                      
REMARK 465     GLY R   425                                                      
REMARK 465     SER R   426                                                      
REMARK 465     ASP R   427                                                      
REMARK 465     ARG R   428                                                      
REMARK 465     VAL R   429                                                      
REMARK 465     MET S     1                                                      
REMARK 465     ALA S     2                                                      
REMARK 465     SER S     3                                                      
REMARK 465     THR S     4                                                      
REMARK 465     ALA S     5                                                      
REMARK 465     VAL S     6                                                      
REMARK 465     MET S     7                                                      
REMARK 465     MET S     8                                                      
REMARK 465     ASP S     9                                                      
REMARK 465     VAL S    10                                                      
REMARK 465     ASP S    11                                                      
REMARK 465     SER S    12                                                      
REMARK 465     SER S    13                                                      
REMARK 465     GLY S    14                                                      
REMARK 465     VAL S    15                                                      
REMARK 465     ASN S    16                                                      
REMARK 465     ASP S    17                                                      
REMARK 465     LEU S    18                                                      
REMARK 465     HIS S    19                                                      
REMARK 465     HIS S    20                                                      
REMARK 465     SER S    21                                                      
REMARK 465     GLU S    22                                                      
REMARK 465     LYS S    23                                                      
REMARK 465     LYS S    24                                                      
REMARK 465     TYR S    25                                                      
REMARK 465     ALA S    26                                                      
REMARK 465     GLU S    27                                                      
REMARK 465     GLU S    28                                                      
REMARK 465     ASP S    29                                                      
REMARK 465     GLN S    30                                                      
REMARK 465     VAL S    31                                                      
REMARK 465     GLN S    32                                                      
REMARK 465     GLU S    33                                                      
REMARK 465     LEU S    34                                                      
REMARK 465     LEU S    35                                                      
REMARK 465     LYS S    36                                                      
REMARK 465     VAL S    37                                                      
REMARK 465     LEU S    38                                                      
REMARK 465     ASN S    39                                                      
REMARK 465     GLU S    40                                                      
REMARK 465     ILE S    41                                                      
REMARK 465     SER S    42                                                      
REMARK 465     LYS S    43                                                      
REMARK 465     THR S    44                                                      
REMARK 465     THR S    45                                                      
REMARK 465     LEU S    46                                                      
REMARK 465     THR S    47                                                      
REMARK 465     LEU S    48                                                      
REMARK 465     ASP S    49                                                      
REMARK 465     PRO S    50                                                      
REMARK 465     ARG S    51                                                      
REMARK 465     TYR S    52                                                      
REMARK 465     ILE S    53                                                      
REMARK 465     TRP S    54                                                      
REMARK 465     ARG S    55                                                      
REMARK 465     SER S    56                                                      
REMARK 465     LEU S    57                                                      
REMARK 465     LYS S    58                                                      
REMARK 465     ASP S    59                                                      
REMARK 465     LEU S    60                                                      
REMARK 465     SER S    61                                                      
REMARK 465     SER S    62                                                      
REMARK 465     LEU S    63                                                      
REMARK 465     ARG S    64                                                      
REMARK 465     ASN S    65                                                      
REMARK 465     GLN S    66                                                      
REMARK 465     GLU S    67                                                      
REMARK 465     LEU S    68                                                      
REMARK 465     LEU S    69                                                      
REMARK 465     ASN S    70                                                      
REMARK 465     ALA S    71                                                      
REMARK 465     GLU S    72                                                      
REMARK 465     THR S    73                                                      
REMARK 465     LEU S    74                                                      
REMARK 465     CYS S    75                                                      
REMARK 465     PHE S    76                                                      
REMARK 465     THR S    77                                                      
REMARK 465     VAL S    78                                                      
REMARK 465     ASN S    79                                                      
REMARK 465     VAL S    80                                                      
REMARK 465     LEU S    81                                                      
REMARK 465     TYR S    82                                                      
REMARK 465     PRO S    83                                                      
REMARK 465     ASP S    84                                                      
REMARK 465     SER S    85                                                      
REMARK 465     SER S    86                                                      
REMARK 465     SER S    87                                                      
REMARK 465     PHE S    88                                                      
REMARK 465     LYS S    89                                                      
REMARK 465     LYS S    90                                                      
REMARK 465     ASN S    91                                                      
REMARK 465     LEU S    92                                                      
REMARK 465     LEU S    93                                                      
REMARK 465     LYS S    94                                                      
REMARK 465     PHE S    95                                                      
REMARK 465     ILE S    96                                                      
REMARK 465     THR S    97                                                      
REMARK 465     SER S    98                                                      
REMARK 465     ASN S    99                                                      
REMARK 465     HIS S   100                                                      
REMARK 465     LYS S   101                                                      
REMARK 465     SER S   102                                                      
REMARK 465     SER S   103                                                      
REMARK 465     VAL S   104                                                      
REMARK 465     PRO S   105                                                      
REMARK 465     GLY S   106                                                      
REMARK 465     SER S   107                                                      
REMARK 465     ALA S   108                                                      
REMARK 465     GLU S   109                                                      
REMARK 465     LEU S   110                                                      
REMARK 465     ARG S   111                                                      
REMARK 465     ASN S   112                                                      
REMARK 465     SER S   113                                                      
REMARK 465     TYR S   114                                                      
REMARK 465     PRO S   115                                                      
REMARK 465     ALA S   116                                                      
REMARK 465     SER S   117                                                      
REMARK 465     PHE S   118                                                      
REMARK 465     TYR S   119                                                      
REMARK 465     SER S   120                                                      
REMARK 465     VAL S   121                                                      
REMARK 465     ASN S   122                                                      
REMARK 465     THR S   123                                                      
REMARK 465     GLU S   124                                                      
REMARK 465     LYS S   125                                                      
REMARK 465     MET S   479                                                      
REMARK 465     ARG S   480                                                      
REMARK 465     TYR S   481                                                      
REMARK 465     PRO S   482                                                      
REMARK 465     GLU S   483                                                      
REMARK 465     ASP S   484                                                      
REMARK 465     LYS S   485                                                      
REMARK 465     LYS S   486                                                      
REMARK 465     THR S   487                                                      
REMARK 465     GLN S   488                                                      
REMARK 465     GLN S   489                                                      
REMARK 465     ASN S   490                                                      
REMARK 465     GLU S   491                                                      
REMARK 465     LYS S   492                                                      
REMARK 465     SER S   493                                                      
REMARK 465     GLU S   494                                                      
REMARK 465     ASN S   495                                                      
REMARK 465     GLY S   496                                                      
REMARK 465     GLU S   497                                                      
REMARK 465     ASN S   498                                                      
REMARK 465     ASP S   499                                                      
REMARK 465     ASP S   500                                                      
REMARK 465     ASP S   501                                                      
REMARK 465     THR S   502                                                      
REMARK 465     LEU S   503                                                      
REMARK 465     ASP S   504                                                      
REMARK 465     GLY S   505                                                      
REMARK 465     ASP S   506                                                      
REMARK 465     LEU S   507                                                      
REMARK 465     MET S   508                                                      
REMARK 465     ASP S   509                                                      
REMARK 465     ASP S   510                                                      
REMARK 465     MET S   511                                                      
REMARK 465     SER S   512                                                      
REMARK 465     ASP S   513                                                      
REMARK 465     ILE S   514                                                      
REMARK 465     SER S   515                                                      
REMARK 465     ASP S   516                                                      
REMARK 465     LEU S   517                                                      
REMARK 465     ASP S   518                                                      
REMARK 465     ASP S   519                                                      
REMARK 465     LEU S   520                                                      
REMARK 465     GLY S   521                                                      
REMARK 465     PHE S   522                                                      
REMARK 465     LEU S   523                                                      
REMARK 465     ILE T   273                                                      
REMARK 465     VAL T   274                                                      
REMARK 465     MET U     1                                                      
REMARK 465     SER U     2                                                      
REMARK 465     LEU U     3                                                      
REMARK 465     GLN U     4                                                      
REMARK 465     VAL U   143                                                      
REMARK 465     LYS U   144                                                      
REMARK 465     ASP U   145                                                      
REMARK 465     ASP U   146                                                      
REMARK 465     GLY U   147                                                      
REMARK 465     THR U   148                                                      
REMARK 465     SER U   149                                                      
REMARK 465     THR U   150                                                      
REMARK 465     ASP U   177                                                      
REMARK 465     VAL U   178                                                      
REMARK 465     ARG U   179                                                      
REMARK 465     ASP U   180                                                      
REMARK 465     GLN U   181                                                      
REMARK 465     ALA U   182                                                      
REMARK 465     ALA U   183                                                      
REMARK 465     GLY U   184                                                      
REMARK 465     GLY U   185                                                      
REMARK 465     LEU U   186                                                      
REMARK 465     SER U   187                                                      
REMARK 465     ASN U   216                                                      
REMARK 465     LYS U   217                                                      
REMARK 465     GLU U   218                                                      
REMARK 465     LEU U   219                                                      
REMARK 465     PRO U   220                                                      
REMARK 465     ILE U   221                                                      
REMARK 465     ASN U   222                                                      
REMARK 465     LEU U   236                                                      
REMARK 465     PRO U   237                                                      
REMARK 465     ASN U   238                                                      
REMARK 465     LEU U   239                                                      
REMARK 465     GLY U   240                                                      
REMARK 465     THR U   241                                                      
REMARK 465     PRO U   242                                                      
REMARK 465     ASP U   243                                                      
REMARK 465     ASP U   244                                                      
REMARK 465     ASP U   245                                                      
REMARK 465     GLU U   246                                                      
REMARK 465     ILE U   247                                                      
REMARK 465     ASP U   248                                                      
REMARK 465     VAL U   249                                                      
REMARK 465     GLU U   250                                                      
REMARK 465     ASN U   251                                                      
REMARK 465     HIS U   252                                                      
REMARK 465     ASP U   253                                                      
REMARK 465     ARG U   254                                                      
REMARK 465     ILE U   255                                                      
REMARK 465     ASN U   256                                                      
REMARK 465     ILE U   257                                                      
REMARK 465     SER U   258                                                      
REMARK 465     LYS U   309                                                      
REMARK 465     GLN U   310                                                      
REMARK 465     SER U   311                                                      
REMARK 465     LYS U   312                                                      
REMARK 465     VAL U   313                                                      
REMARK 465     SER U   314                                                      
REMARK 465     ASP U   315                                                      
REMARK 465     ASP U   316                                                      
REMARK 465     SER U   317                                                      
REMARK 465     GLU U   318                                                      
REMARK 465     SER U   319                                                      
REMARK 465     GLU U   320                                                      
REMARK 465     SER U   321                                                      
REMARK 465     GLY U   322                                                      
REMARK 465     ASP U   323                                                      
REMARK 465     LYS U   324                                                      
REMARK 465     GLU U   325                                                      
REMARK 465     ALA U   326                                                      
REMARK 465     THR U   327                                                      
REMARK 465     ALA U   328                                                      
REMARK 465     PRO U   329                                                      
REMARK 465     LEU U   330                                                      
REMARK 465     ILE U   331                                                      
REMARK 465     GLN U   332                                                      
REMARK 465     ARG U   333                                                      
REMARK 465     LYS U   334                                                      
REMARK 465     ASN U   335                                                      
REMARK 465     LYS U   336                                                      
REMARK 465     LYS U   337                                                      
REMARK 465     ASN U   338                                                      
REMARK 465     MET V     1                                                      
REMARK 465     GLU V     2                                                      
REMARK 465     ARG V     3                                                      
REMARK 465     LEU V     4                                                      
REMARK 465     GLN V     5                                                      
REMARK 465     ARG V     6                                                      
REMARK 465     LEU V     7                                                      
REMARK 465     MET V     8                                                      
REMARK 465     MET V     9                                                      
REMARK 465     ASN V    10                                                      
REMARK 465     SER V    11                                                      
REMARK 465     LYS V    12                                                      
REMARK 465     VAL V    13                                                      
REMARK 465     GLY V    14                                                      
REMARK 465     SER V    15                                                      
REMARK 465     ALA V    16                                                      
REMARK 465     ASP V    17                                                      
REMARK 465     THR V    18                                                      
REMARK 465     GLY V    19                                                      
REMARK 465     ARG V    20                                                      
REMARK 465     ASP V    21                                                      
REMARK 465     ASP V    22                                                      
REMARK 465     GLU V   169                                                      
REMARK 465     PRO V   170                                                      
REMARK 465     ARG V   171                                                      
REMARK 465     GLN V   172                                                      
REMARK 465     THR V   173                                                      
REMARK 465     THR V   174                                                      
REMARK 465     SER V   175                                                      
REMARK 465     ASN V   176                                                      
REMARK 465     THR V   177                                                      
REMARK 465     GLY V   178                                                      
REMARK 465     LEU V   179                                                      
REMARK 465     LYS V   218                                                      
REMARK 465     GLU V   219                                                      
REMARK 465     GLN V   220                                                      
REMARK 465     TRP V   221                                                      
REMARK 465     GLN V   222                                                      
REMARK 465     SER V   223                                                      
REMARK 465     GLY V   224                                                      
REMARK 465     LEU V   225                                                      
REMARK 465     LYS V   226                                                      
REMARK 465     MET V   227                                                      
REMARK 465     TYR V   228                                                      
REMARK 465     ASP V   229                                                      
REMARK 465     TYR V   270                                                      
REMARK 465     VAL V   271                                                      
REMARK 465     GLY V   272                                                      
REMARK 465     ARG V   273                                                      
REMARK 465     GLN V   274                                                      
REMARK 465     ASP V   275                                                      
REMARK 465     GLY V   299                                                      
REMARK 465     VAL V   300                                                      
REMARK 465     ASN V   301                                                      
REMARK 465     SER V   302                                                      
REMARK 465     VAL V   303                                                      
REMARK 465     ALA V   304                                                      
REMARK 465     ILE V   305                                                      
REMARK 465     LYS V   306                                                      
REMARK 465     GLY W   198                                                      
REMARK 465     MET W   199                                                      
REMARK 465     GLY W   200                                                      
REMARK 465     ALA W   201                                                      
REMARK 465     PHE W   202                                                      
REMARK 465     GLY W   203                                                      
REMARK 465     GLY W   204                                                      
REMARK 465     SER W   205                                                      
REMARK 465     GLY W   206                                                      
REMARK 465     GLY W   207                                                      
REMARK 465     ASP W   208                                                      
REMARK 465     SER W   209                                                      
REMARK 465     ASP W   210                                                      
REMARK 465     ALA W   211                                                      
REMARK 465     ASN W   212                                                      
REMARK 465     GLY W   213                                                      
REMARK 465     THR W   214                                                      
REMARK 465     PHE W   215                                                      
REMARK 465     MET W   216                                                      
REMARK 465     ASP W   217                                                      
REMARK 465     PHE W   218                                                      
REMARK 465     GLY W   219                                                      
REMARK 465     VAL W   220                                                      
REMARK 465     ASP W   221                                                      
REMARK 465     PRO W   222                                                      
REMARK 465     SER W   223                                                      
REMARK 465     MET W   224                                                      
REMARK 465     ASP W   225                                                      
REMARK 465     PRO W   226                                                      
REMARK 465     GLU W   227                                                      
REMARK 465     LEU W   228                                                      
REMARK 465     ALA W   229                                                      
REMARK 465     MET W   230                                                      
REMARK 465     ALA W   231                                                      
REMARK 465     LEU W   232                                                      
REMARK 465     ARG W   233                                                      
REMARK 465     LEU W   234                                                      
REMARK 465     SER W   235                                                      
REMARK 465     MET W   236                                                      
REMARK 465     GLU W   237                                                      
REMARK 465     GLU W   238                                                      
REMARK 465     GLU W   239                                                      
REMARK 465     GLN W   240                                                      
REMARK 465     GLN W   241                                                      
REMARK 465     ARG W   242                                                      
REMARK 465     GLN W   243                                                      
REMARK 465     GLU W   244                                                      
REMARK 465     ARG W   245                                                      
REMARK 465     LEU W   246                                                      
REMARK 465     ARG W   247                                                      
REMARK 465     GLN W   248                                                      
REMARK 465     GLN W   249                                                      
REMARK 465     GLN W   250                                                      
REMARK 465     GLN W   251                                                      
REMARK 465     GLN W   252                                                      
REMARK 465     GLN W   253                                                      
REMARK 465     ASP W   254                                                      
REMARK 465     GLN W   255                                                      
REMARK 465     PRO W   256                                                      
REMARK 465     GLU W   257                                                      
REMARK 465     GLN W   258                                                      
REMARK 465     SER W   259                                                      
REMARK 465     GLU W   260                                                      
REMARK 465     GLN W   261                                                      
REMARK 465     PRO W   262                                                      
REMARK 465     GLU W   263                                                      
REMARK 465     GLN W   264                                                      
REMARK 465     HIS W   265                                                      
REMARK 465     GLN W   266                                                      
REMARK 465     ASP W   267                                                      
REMARK 465     LYS W   268                                                      
REMARK 465     MET X     1                                                      
REMARK 465     SER X     2                                                      
REMARK 465     MET X     3                                                      
REMARK 465     SER X     4                                                      
REMARK 465     SER X     5                                                      
REMARK 465     THR X     6                                                      
REMARK 465     GLU X   134                                                      
REMARK 465     SER X   135                                                      
REMARK 465     ASP X   136                                                      
REMARK 465     GLU X   137                                                      
REMARK 465     GLU X   138                                                      
REMARK 465     GLU X   139                                                      
REMARK 465     SER X   140                                                      
REMARK 465     ASN X   141                                                      
REMARK 465     ASP X   142                                                      
REMARK 465     GLU X   143                                                      
REMARK 465     LYS X   144                                                      
REMARK 465     GLN X   145                                                      
REMARK 465     LYS X   146                                                      
REMARK 465     ALA X   147                                                      
REMARK 465     GLN X   148                                                      
REMARK 465     ASP X   149                                                      
REMARK 465     VAL X   150                                                      
REMARK 465     ASP X   151                                                      
REMARK 465     VAL X   152                                                      
REMARK 465     SER X   153                                                      
REMARK 465     MET X   154                                                      
REMARK 465     GLN X   155                                                      
REMARK 465     ASP X   156                                                      
REMARK 465     MET Y     1                                                      
REMARK 465     SER Y     2                                                      
REMARK 465     THR Y     3                                                      
REMARK 465     ASP Y     4                                                      
REMARK 465     VAL Y     5                                                      
REMARK 465     ALA Y     6                                                      
REMARK 465     ALA Y     7                                                      
REMARK 465     ALA Y     8                                                      
REMARK 465     GLN Y     9                                                      
REMARK 465     ALA Y    10                                                      
REMARK 465     GLN Y    11                                                      
REMARK 465     SER Y    12                                                      
REMARK 465     LYS Y    13                                                      
REMARK 465     ILE Y    14                                                      
REMARK 465     ASP Y    15                                                      
REMARK 465     LEU Y    16                                                      
REMARK 465     THR Y    17                                                      
REMARK 465     LYS Y    18                                                      
REMARK 465     LYS Y    19                                                      
REMARK 465     LYS Y    20                                                      
REMARK 465     ASN Y    21                                                      
REMARK 465     GLU Y    22                                                      
REMARK 465     GLU Y    23                                                      
REMARK 465     ILE Y    24                                                      
REMARK 465     ASN Y    25                                                      
REMARK 465     LYS Y    26                                                      
REMARK 465     LYS Y    27                                                      
REMARK 465     SER Y    28                                                      
REMARK 465     LEU Y    29                                                      
REMARK 465     GLU Y    30                                                      
REMARK 465     GLU Y    31                                                      
REMARK 465     ASP Y    32                                                      
REMARK 465     ASP Y    33                                                      
REMARK 465     GLU Y    34                                                      
REMARK 465     PHE Y    35                                                      
REMARK 465     GLU Y    36                                                      
REMARK 465     ASP Y    37                                                      
REMARK 465     PHE Y    38                                                      
REMARK 465     PRO Y    39                                                      
REMARK 465     ILE Y    40                                                      
REMARK 465     ASP Y    41                                                      
REMARK 465     THR Y    42                                                      
REMARK 465     TRP Y    43                                                      
REMARK 465     ALA Y    44                                                      
REMARK 465     ASN Y    45                                                      
REMARK 465     GLY Y    46                                                      
REMARK 465     GLU Y    47                                                      
REMARK 465     THR Y    48                                                      
REMARK 465     ILE Y    49                                                      
REMARK 465     LYS Y    50                                                      
REMARK 465     SER Y    51                                                      
REMARK 465     ASN Y    52                                                      
REMARK 465     ALA Y    53                                                      
REMARK 465     VAL Y    54                                                      
REMARK 465     THR Y    55                                                      
REMARK 465     GLN Y    56                                                      
REMARK 465     THR Y    57                                                      
REMARK 465     ASN Y    58                                                      
REMARK 465     ILE Y    59                                                      
REMARK 465     TRP Y    60                                                      
REMARK 465     GLU Y    61                                                      
REMARK 465     GLU Y    62                                                      
REMARK 465     ASN Y    63                                                      
REMARK 465     TRP Y    64                                                      
REMARK 465     ASP Y    65                                                      
REMARK 465     ASP Y    66                                                      
REMARK 465     VAL Y    67                                                      
REMARK 465     GLU Y    68                                                      
REMARK 465     VAL Y    69                                                      
REMARK 465     ASP Y    70                                                      
REMARK 465     MET Z     1                                                      
REMARK 465     VAL Z     2                                                      
REMARK 465     ASP Z     3                                                      
REMARK 465     GLU Z     4                                                      
REMARK 465     SER Z     5                                                      
REMARK 465     ASP Z     6                                                      
REMARK 465     LYS Z     7                                                      
REMARK 465     LYS Z     8                                                      
REMARK 465     GLN Z     9                                                      
REMARK 465     GLN Z    10                                                      
REMARK 465     THR Z    11                                                      
REMARK 465     ILE Z    12                                                      
REMARK 465     ASP Z    13                                                      
REMARK 465     GLU Z    14                                                      
REMARK 465     GLN Z    15                                                      
REMARK 465     SER Z    16                                                      
REMARK 465     GLN Z    17                                                      
REMARK 465     ILE Z    18                                                      
REMARK 465     SER Z    19                                                      
REMARK 465     PRO Z    20                                                      
REMARK 465     GLU Z    21                                                      
REMARK 465     LYS Z    22                                                      
REMARK 465     GLN Z    23                                                      
REMARK 465     THR Z    24                                                      
REMARK 465     PRO Z    25                                                      
REMARK 465     ASN Z    26                                                      
REMARK 465     LYS Z    27                                                      
REMARK 465     LYS Z    28                                                      
REMARK 465     ASP Z    29                                                      
REMARK 465     LYS Z    30                                                      
REMARK 465     LYS Z    31                                                      
REMARK 465     LYS Z    32                                                      
REMARK 465     GLU Z    33                                                      
REMARK 465     GLU Z    34                                                      
REMARK 465     GLU Z    35                                                      
REMARK 465     GLU Z    36                                                      
REMARK 465     GLN Z    37                                                      
REMARK 465     LEU Z    38                                                      
REMARK 465     SER Z    39                                                      
REMARK 465     GLU Z    40                                                      
REMARK 465     GLU Z    41                                                      
REMARK 465     ASP Z    42                                                      
REMARK 465     ALA Z    43                                                      
REMARK 465     LYS Z    44                                                      
REMARK 465     LEU Z    45                                                      
REMARK 465     LYS Z    46                                                      
REMARK 465     THR Z    47                                                      
REMARK 465     ASP Z    48                                                      
REMARK 465     PRO Z   626                                                      
REMARK 465     LYS Z   627                                                      
REMARK 465     ASN Z   628                                                      
REMARK 465     VAL Z   629                                                      
REMARK 465     LYS Z   630                                                      
REMARK 465     GLY Z   631                                                      
REMARK 465     GLU Z   632                                                      
REMARK 465     GLU Z   633                                                      
REMARK 465     ASP Z   634                                                      
REMARK 465     ALA Z   635                                                      
REMARK 465     ASP Z   636                                                      
REMARK 465     GLU Z   637                                                      
REMARK 465     GLU Z   638                                                      
REMARK 465     GLU Z   639                                                      
REMARK 465     THR Z   640                                                      
REMARK 465     ALA Z   641                                                      
REMARK 465     GLU Z   642                                                      
REMARK 465     GLY Z   643                                                      
REMARK 465     GLN Z   644                                                      
REMARK 465     THR Z   645                                                      
REMARK 465     ASN Z   646                                                      
REMARK 465     SER Z   647                                                      
REMARK 465     ILE Z   648                                                      
REMARK 465     SER Z   649                                                      
REMARK 465     ASP Z   650                                                      
REMARK 465     PHE Z   651                                                      
REMARK 465     LEU Z   652                                                      
REMARK 465     GLY Z   653                                                      
REMARK 465     GLU Z   654                                                      
REMARK 465     GLN Z   655                                                      
REMARK 465     VAL Z   656                                                      
REMARK 465     ASN Z   657                                                      
REMARK 465     GLU Z   658                                                      
REMARK 465     PRO Z   659                                                      
REMARK 465     THR Z   660                                                      
REMARK 465     LYS Z   661                                                      
REMARK 465     ASN Z   662                                                      
REMARK 465     GLU Z   663                                                      
REMARK 465     GLU Z   664                                                      
REMARK 465     ALA Z   665                                                      
REMARK 465     GLU Z   666                                                      
REMARK 465     ILE Z   667                                                      
REMARK 465     GLU Z   668                                                      
REMARK 465     VAL Z   669                                                      
REMARK 465     ASP Z   670                                                      
REMARK 465     GLU Z   671                                                      
REMARK 465     MET Z   672                                                      
REMARK 465     GLU Z   673                                                      
REMARK 465     VAL Z   674                                                      
REMARK 465     ASP Z   675                                                      
REMARK 465     ALA Z   676                                                      
REMARK 465     GLU Z   677                                                      
REMARK 465     GLY Z   678                                                      
REMARK 465     GLU Z   679                                                      
REMARK 465     GLU Z   680                                                      
REMARK 465     VAL Z   681                                                      
REMARK 465     GLU Z   682                                                      
REMARK 465     VAL Z   683                                                      
REMARK 465     LYS Z   684                                                      
REMARK 465     ALA Z   685                                                      
REMARK 465     GLU Z   686                                                      
REMARK 465     ILE Z   687                                                      
REMARK 465     THR Z   688                                                      
REMARK 465     GLU Z   689                                                      
REMARK 465     LYS Z   690                                                      
REMARK 465     LYS Z   691                                                      
REMARK 465     ASN Z   692                                                      
REMARK 465     GLY Z   693                                                      
REMARK 465     GLU Z   694                                                      
REMARK 465     SER Z   695                                                      
REMARK 465     LEU Z   696                                                      
REMARK 465     GLU Z   697                                                      
REMARK 465     GLY Z   698                                                      
REMARK 465     GLU Z   699                                                      
REMARK 465     GLU Z   700                                                      
REMARK 465     ILE Z   701                                                      
REMARK 465     LYS Z   702                                                      
REMARK 465     SER Z   703                                                      
REMARK 465     GLU Z   704                                                      
REMARK 465     GLU Z   705                                                      
REMARK 465     LYS Z   706                                                      
REMARK 465     LYS Z   707                                                      
REMARK 465     GLY Z   708                                                      
REMARK 465     LYS Z   709                                                      
REMARK 465     SER Z   710                                                      
REMARK 465     SER Z   711                                                      
REMARK 465     ASP Z   712                                                      
REMARK 465     LYS Z   713                                                      
REMARK 465     ASP Z   714                                                      
REMARK 465     ALA Z   715                                                      
REMARK 465     THR Z   716                                                      
REMARK 465     THR Z   717                                                      
REMARK 465     ASP Z   718                                                      
REMARK 465     GLY Z   719                                                      
REMARK 465     LYS Z   720                                                      
REMARK 465     ASN Z   721                                                      
REMARK 465     ASP Z   722                                                      
REMARK 465     ASP Z   723                                                      
REMARK 465     GLU Z   724                                                      
REMARK 465     GLU Z   725                                                      
REMARK 465     GLU Z   726                                                      
REMARK 465     GLU Z   727                                                      
REMARK 465     LYS Z   728                                                      
REMARK 465     GLU Z   729                                                      
REMARK 465     ALA Z   730                                                      
REMARK 465     GLY Z   731                                                      
REMARK 465     ILE Z   732                                                      
REMARK 465     VAL Z   733                                                      
REMARK 465     ASP Z   734                                                      
REMARK 465     GLU Z   735                                                      
REMARK 465     ALA Z   932                                                      
REMARK 465     VAL Z   933                                                      
REMARK 465     GLU Z   934                                                      
REMARK 465     THR Z   935                                                      
REMARK 465     VAL Z   936                                                      
REMARK 465     GLY Z   937                                                      
REMARK 465     GLN Z   938                                                      
REMARK 465     ALA Z   939                                                      
REMARK 465     GLY Z   940                                                      
REMARK 465     ARG Z   941                                                      
REMARK 465     PRO Z   942                                                      
REMARK 465     LYS Z   943                                                      
REMARK 465     LYS Z   944                                                      
REMARK 465     ILE Z   945                                                      
REMARK 465     THR Z   946                                                      
REMARK 465     GLY Z   947                                                      
REMARK 465     TRP Z   948                                                      
REMARK 465     ILE Z   949                                                      
REMARK 465     THR Z   950                                                      
REMARK 465     GLN Z   951                                                      
REMARK 465     SER Z   952                                                      
REMARK 465     THR Z   953                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    PHE P   131     CE   MET P   171              1.04            
REMARK 500   O    GLY K   248     CD   PRO K   251              1.13            
REMARK 500   CD2  LEU Q    61     OH   TYR Q    65              1.19            
REMARK 500   CE2  PHE O   185     CD2  LEU O   223              1.22            
REMARK 500   CD   LYS Z   318     NE2  HIS Z   463              1.23            
REMARK 500   O    ASP T   244     CD1  TYR T   245              1.26            
REMARK 500   CD1  LEU U    38     O    GLU U    87              1.33            
REMARK 500   O    ILE Z   102     CD   LYS Z   112              1.37            
REMARK 500   O    GLU Q   414     OE1  GLN Q   418              1.37            
REMARK 500   CE1  TYR H   145     CG1  ILE H   147              1.37            
REMARK 500   CA   LEU W   154     N    ASP W   155              1.38            
REMARK 500   NH1  ARG K   185     OE1  GLU K   189              1.40            
REMARK 500   NH2  ARG A    24     OE1  GLU A    29              1.45            
REMARK 500   O    VAL L   252     CG1  ILE M   256              1.45            
REMARK 500   N    PHE K   242     N    VAL K   243              1.46            
REMARK 500   CB   SER O    42     CG2  THR O    46              1.46            
REMARK 500   C    LEU W   154     CA   ASP W   155              1.46            
REMARK 500   CB   SER T    91     OH   TYR T   128              1.48            
REMARK 500   O    GLN W    38     N    ALA W    39              1.48            
REMARK 500   CE   LYS Z   318     CE1  HIS Z   463              1.49            
REMARK 500   CG2  ILE U   106     CE2  PHE U   110              1.50            
REMARK 500   CD1  LEU L   104     O    THR M   126              1.50            
REMARK 500   CG   ASP 1    57     CE1  TYR A   106              1.52            
REMARK 500   O    VAL L   252     CG2  ILE M   256              1.52            
REMARK 500   OH   TYR H   145     CB   ILE H   147              1.52            
REMARK 500   CB   ASP 1    57     CE1  TYR A   106              1.53            
REMARK 500   OE2  GLU J    39     NH2  ARG J    42              1.53            
REMARK 500   CG   ASN T   225     CG   GLU T   246              1.53            
REMARK 500   O    PRO N   744     CD1  LEU N   745              1.54            
REMARK 500   C    PHE K   242     CA   VAL K   243              1.54            
REMARK 500   O    ASP V    60     CD1  TYR V    61              1.56            
REMARK 500   O    VAL L   252     CB   ILE M   256              1.56            
REMARK 500   NE2  HIS Z   307     NZ   LYS Z   334              1.57            
REMARK 500   ND2  ASN T   225     CG   GLU T   246              1.59            
REMARK 500   O    CYS V   116     CD1  TRP V   117              1.59            
REMARK 500   CE   LYS Z   318     NE2  HIS Z   463              1.60            
REMARK 500   O    VAL L   252     CD1  ILE M   256              1.60            
REMARK 500   CZ   PHE O   185     CD2  LEU O   223              1.61            
REMARK 500   O    VAL D   203     OE1  GLN D   204              1.62            
REMARK 500   NZ   LYS Z   318     O    ALA Z   459              1.62            
REMARK 500   CE2  TYR G   200     CB   ALA G   242              1.63            
REMARK 500   O    MET M    58     N    LEU M    59              1.65            
REMARK 500   NH2  ARG K   281     C    GLN K   285              1.67            
REMARK 500   NE1  TRP V   117     CB   TYR V   196              1.68            
REMARK 500   NH2  ARG Q   202     OG   SER Q   222              1.68            
REMARK 500   O    PHE P   303     NE2  HIS P   348              1.68            
REMARK 500   N    GLY J    69     ND2  ASN K   144              1.69            
REMARK 500   CE1  HIS Z   307     NZ   LYS Z   334              1.69            
REMARK 500   OE2  GLU H   286     NH2  ARG H   289              1.70            
REMARK 500   CD2  PHE O   185     CD2  LEU O   223              1.70            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     248 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    HIS 1  38   CG    HIS 1  38   CD2     0.102                       
REMARK 500    HIS 1  62   CG    HIS 1  62   CD2     0.102                       
REMARK 500    PRO 1  73   CD    PRO 1  73   N       0.084                       
REMARK 500    HIS 1 120   CG    HIS 1 120   CD2     0.103                       
REMARK 500    HIS 1 157   CG    HIS 1 157   CD2     0.102                       
REMARK 500    PRO 1 190   CD    PRO 1 190   N       0.100                       
REMARK 500    HIS 2  35   CG    HIS 2  35   CD2     0.102                       
REMARK 500    HIS 2  66   CG    HIS 2  66   CD2     0.102                       
REMARK 500    HIS 2  86   CG    HIS 2  86   CD2     0.102                       
REMARK 500    HIS 2  93   CG    HIS 2  93   CD2     0.101                       
REMARK 500    HIS 2 109   CG    HIS 2 109   CD2     0.103                       
REMARK 500    HIS 2 114   CG    HIS 2 114   CD2     0.102                       
REMARK 500    HIS 2 116   CG    HIS 2 116   CD2     0.102                       
REMARK 500    HIS 2 141   CG    HIS 2 141   CD2     0.101                       
REMARK 500    HIS 3  36   CG    HIS 3  36   CD2     0.102                       
REMARK 500    HIS 3  39   CG    HIS 3  39   CD2     0.102                       
REMARK 500    PRO 3 147   CD    PRO 3 147   N       0.113                       
REMARK 500    PRO 3 151   CD    PRO 3 151   N       0.093                       
REMARK 500    HIS 4  40   CG    HIS 4  40   CD2     0.102                       
REMARK 500    HIS 4 132   CG    HIS 4 132   CD2     0.102                       
REMARK 500    HIS 4 145   CG    HIS 4 145   CD2     0.102                       
REMARK 500    HIS 4 146   CG    HIS 4 146   CD2     0.101                       
REMARK 500    PRO 4 172   CD    PRO 4 172   N       0.117                       
REMARK 500    HIS 5  66   CG    HIS 5  66   CD2     0.102                       
REMARK 500    GLY 5  94   CA    GLY 5  94   C      -0.118                       
REMARK 500    HIS 5 166   CG    HIS 5 166   CD2     0.101                       
REMARK 500    HIS 5 179   CG    HIS 5 179   CD2     0.102                       
REMARK 500    HIS 5 188   CG    HIS 5 188   CD2     0.102                       
REMARK 500    HIS 5 191   CG    HIS 5 191   CD2     0.101                       
REMARK 500    GLY 6  47   CA    GLY 6  47   C      -0.104                       
REMARK 500    HIS 6  67   CG    HIS 6  67   CD2     0.101                       
REMARK 500    HIS 6  70   CG    HIS 6  70   CD2     0.102                       
REMARK 500    HIS 6  86   CG    HIS 6  86   CD2     0.102                       
REMARK 500    HIS 6  99   CG    HIS 6  99   CD2     0.102                       
REMARK 500    PRO 6 153   CD    PRO 6 153   N       0.096                       
REMARK 500    PRO 6 162   CD    PRO 6 162   N       0.089                       
REMARK 500    HIS 6 186   CG    HIS 6 186   CD2     0.102                       
REMARK 500    GLY 7  44   CA    GLY 7  44   C      -0.096                       
REMARK 500    HIS 7  54   CG    HIS 7  54   CD2     0.101                       
REMARK 500    HIS 7 141   CG    HIS 7 141   CD2     0.101                       
REMARK 500    THR 7 222   N     THR 7 222   CA     -0.123                       
REMARK 500    HIS A  15   CG    HIS A  15   CD2     0.102                       
REMARK 500    PRO A  66   CD    PRO A  66   N       0.120                       
REMARK 500    PRO A 152   CD    PRO A 152   N       0.091                       
REMARK 500    GLY A 165   CA    GLY A 165   C      -0.122                       
REMARK 500    PRO A 173   CD    PRO A 173   N       0.102                       
REMARK 500    HIS A 185   CG    HIS A 185   CD2     0.102                       
REMARK 500    HIS A 193   CG    HIS A 193   CD2     0.102                       
REMARK 500    HIS A 209   CG    HIS A 209   CD2     0.103                       
REMARK 500    HIS B  94   CG    HIS B  94   CD2     0.102                       
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     258 BOND DEVIATIONS.                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    PRO 1 114   C   -  N   -  CA  ANGL. DEV. =  10.3 DEGREES          
REMARK 500    PRO 5 110   C   -  N   -  CA  ANGL. DEV. =   9.1 DEGREES          
REMARK 500    THR 6  22   N   -  CA  -  C   ANGL. DEV. = -17.2 DEGREES          
REMARK 500    GLU 6  31   N   -  CA  -  C   ANGL. DEV. = -17.1 DEGREES          
REMARK 500    GLY A  11   N   -  CA  -  C   ANGL. DEV. = -16.1 DEGREES          
REMARK 500    ILE A  87   CA  -  C   -  N   ANGL. DEV. =  18.4 DEGREES          
REMARK 500    PRO A 152   C   -  N   -  CA  ANGL. DEV. =   9.3 DEGREES          
REMARK 500    GLU A 242   CB  -  CA  -  C   ANGL. DEV. = -13.1 DEGREES          
REMARK 500    GLU A 242   CA  -  CB  -  CG  ANGL. DEV. =  17.1 DEGREES          
REMARK 500    VAL A 246   CA  -  CB  -  CG2 ANGL. DEV. =  -9.9 DEGREES          
REMARK 500    ILE B 214   N   -  CA  -  C   ANGL. DEV. = -17.0 DEGREES          
REMARK 500    PRO E 160   C   -  N   -  CA  ANGL. DEV. =   9.0 DEGREES          
REMARK 500    ASN H  54   O   -  C   -  N   ANGL. DEV. =  -9.6 DEGREES          
REMARK 500    VAL H 163   O   -  C   -  N   ANGL. DEV. = -10.1 DEGREES          
REMARK 500    MET H 172   N   -  CA  -  C   ANGL. DEV. =  16.4 DEGREES          
REMARK 500    PRO H 188   C   -  N   -  CD  ANGL. DEV. = -41.2 DEGREES          
REMARK 500    PRO H 251   C   -  N   -  CA  ANGL. DEV. =  10.0 DEGREES          
REMARK 500    PRO H 252   C   -  N   -  CA  ANGL. DEV. =  11.0 DEGREES          
REMARK 500    LEU H 279   CA  -  C   -  N   ANGL. DEV. = -24.4 DEGREES          
REMARK 500    LEU H 279   O   -  C   -  N   ANGL. DEV. =  25.3 DEGREES          
REMARK 500    VAL H 280   C   -  N   -  CA  ANGL. DEV. = -21.0 DEGREES          
REMARK 500    VAL H 280   O   -  C   -  N   ANGL. DEV. = -10.5 DEGREES          
REMARK 500    GLY H 285   O   -  C   -  N   ANGL. DEV. =  -9.9 DEGREES          
REMARK 500    TYR I 256   CB  -  CG  -  CD1 ANGL. DEV. =  -4.1 DEGREES          
REMARK 500    PRO J  68   C   -  N   -  CA  ANGL. DEV. =   9.6 DEGREES          
REMARK 500    PRO J 307   C   -  N   -  CA  ANGL. DEV. =  10.6 DEGREES          
REMARK 500    GLU K  55   C   -  N   -  CA  ANGL. DEV. =  17.8 DEGREES          
REMARK 500    PRO K 331   C   -  N   -  CA  ANGL. DEV. =   9.5 DEGREES          
REMARK 500    PRO K 341   C   -  N   -  CA  ANGL. DEV. =   9.2 DEGREES          
REMARK 500    PRO K 341   C   -  N   -  CD  ANGL. DEV. = -13.1 DEGREES          
REMARK 500    GLY L 257   O   -  C   -  N   ANGL. DEV. = -14.3 DEGREES          
REMARK 500    MET M  58   O   -  C   -  N   ANGL. DEV. = -33.7 DEGREES          
REMARK 500    LEU M 251   CA  -  C   -  N   ANGL. DEV. = -17.6 DEGREES          
REMARK 500    VAL M 252   C   -  N   -  CA  ANGL. DEV. = -19.8 DEGREES          
REMARK 500    ARG N 762   CD  -  NE  -  CZ  ANGL. DEV. = -13.0 DEGREES          
REMARK 500    ARG N 762   NE  -  CZ  -  NH1 ANGL. DEV. =  -3.1 DEGREES          
REMARK 500    TYR N 776   CG  -  CD2 -  CE2 ANGL. DEV. =  -7.5 DEGREES          
REMARK 500    TYR N 776   CZ  -  CE2 -  CD2 ANGL. DEV. =   6.0 DEGREES          
REMARK 500    ASP N 780   CB  -  CG  -  OD1 ANGL. DEV. =   8.2 DEGREES          
REMARK 500    PHE N 782   C   -  N   -  CA  ANGL. DEV. =  17.0 DEGREES          
REMARK 500    ARG N 889   NE  -  CZ  -  NH1 ANGL. DEV. =  11.5 DEGREES          
REMARK 500    ARG N 889   NE  -  CZ  -  NH2 ANGL. DEV. =  -5.1 DEGREES          
REMARK 500    PHE N 890   CB  -  CG  -  CD2 ANGL. DEV. =  -6.5 DEGREES          
REMARK 500    ARG N 906   NE  -  CZ  -  NH1 ANGL. DEV. =   3.3 DEGREES          
REMARK 500    GLU O 346   C   -  N   -  CA  ANGL. DEV. =  18.2 DEGREES          
REMARK 500    ARG P  47   NE  -  CZ  -  NH1 ANGL. DEV. =   3.8 DEGREES          
REMARK 500    ARG P  47   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.5 DEGREES          
REMARK 500    ASP P  51   CB  -  CG  -  OD2 ANGL. DEV. =  -7.2 DEGREES          
REMARK 500    ARG P  69   NE  -  CZ  -  NH1 ANGL. DEV. =   5.0 DEGREES          
REMARK 500    ARG P  69   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.4 DEGREES          
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      86 ANGLE DEVIATIONS.                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LYS 1  -8     -135.56     44.63                                   
REMARK 500    SER 1   2      104.32   -162.27                                   
REMARK 500    PHE 1   8     -158.83   -141.58                                   
REMARK 500    ARG 1  19      128.46    170.20                                   
REMARK 500    ALA 1  24        4.90   -161.62                                   
REMARK 500    ASN 1  92      -10.20   -150.37                                   
REMARK 500    ASN 1 106        4.97   -157.60                                   
REMARK 500    LYS 1 107     -148.47     64.82                                   
REMARK 500    PRO 1 114      157.49    -46.19                                   
REMARK 500    CYS 2  31       84.45    177.26                                   
REMARK 500    LYS 2 143       57.71   -158.41                                   
REMARK 500    ASP 2 145      172.25     78.10                                   
REMARK 500    SER 2 171      177.48     66.95                                   
REMARK 500    ALA 2 184      151.98    178.02                                   
REMARK 500    ARG 2 196      173.83    -51.27                                   
REMARK 500    LYS 2 201      146.68     89.89                                   
REMARK 500    SER 3  -5       -3.21   -163.48                                   
REMARK 500    LEU 3  18       16.36   -146.39                                   
REMARK 500    GLN 3  23     -146.80     63.36                                   
REMARK 500    PHE 3  31      116.87   -160.72                                   
REMARK 500    ARG 3  89       62.20   -161.57                                   
REMARK 500    SER 3 107      -12.04   -162.52                                   
REMARK 500    LYS 3 125       33.40   -152.66                                   
REMARK 500    ASP 3 126      -67.76   -138.51                                   
REMARK 500    ALA 3 133       38.05    -88.92                                   
REMARK 500    SER 3 172       19.86   -145.79                                   
REMARK 500    ASP 4  29       21.42   -154.59                                   
REMARK 500    HIS 4  40       21.78   -154.16                                   
REMARK 500    ASP 4 150       64.40     97.31                                   
REMARK 500    PHE 4 175       -6.00   -152.56                                   
REMARK 500    LYS 4 176       74.19     57.67                                   
REMARK 500    PHE 4 194        8.82   -163.76                                   
REMARK 500    ALA 4 196       -6.59   -147.09                                   
REMARK 500    ARG 5  19      116.59    172.53                                   
REMARK 500    ARG 5  33      -23.42   -151.48                                   
REMARK 500    ALA 5  46      148.99    159.81                                   
REMARK 500    LEU 5  95      118.37     81.87                                   
REMARK 500    GLU 5 108      -25.56   -154.68                                   
REMARK 500    ASP 5 125      -26.98   -148.89                                   
REMARK 500    SER 5 131       -7.77   -148.40                                   
REMARK 500    LYS 5 145      102.35   -170.12                                   
REMARK 500    LEU 5 148      147.44    168.07                                   
REMARK 500    ALA 5 169       31.19    -96.51                                   
REMARK 500    PHE 5 207       27.06     85.91                                   
REMARK 500    ASN 5 208       12.41   -172.13                                   
REMARK 500    ASN 6  -2        8.77   -153.90                                   
REMARK 500    ASP 6  10       -2.32   -169.09                                   
REMARK 500    ASP 6  23     -127.97     49.97                                   
REMARK 500    GLU 6  31      113.20   -173.31                                   
REMARK 500    ASN 6  40       25.92     80.88                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     757 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 LEU 1   -2     GLY 1   -1                 -149.49                    
REMARK 500 GLN 6   -9     PHE 6   -8                 -144.23                    
REMARK 500 ARG 7   33     LEU 7   34                  147.30                    
REMARK 500 ASN 7  100     PRO 7  101                 -143.29                    
REMARK 500 GLY A   85     PRO A   86                 -149.94                    
REMARK 500 GLY A  172     PRO A  173                 -149.44                    
REMARK 500 ASP D   56     THR D   57                 -148.70                    
REMARK 500 GLY F   32     SER F   33                 -147.92                    
REMARK 500 MET H  172     ARG H  173                  125.55                    
REMARK 500 ASN H  182     ILE H  183                  144.62                    
REMARK 500 PRO H  188     PRO H  189                  146.26                    
REMARK 500 ASP H  192     PRO H  193                 -148.08                    
REMARK 500 PRO H  204     ASP H  205                 -145.48                    
REMARK 500 LYS J   82     LYS J   83                  148.96                    
REMARK 500 ASN L   80     ILE L   81                  138.93                    
REMARK 500 ILE L   81     ARG L   82                 -138.42                    
REMARK 500 ASN N  346     SER N  347                 -147.98                    
REMARK 500 GLN N  667     THR N  668                 -148.52                    
REMARK 500 ASP N  780     ALA N  781                  148.07                    
REMARK 500 PRO N  892     VAL N  893                 -149.51                    
REMARK 500 ARG N  906     ASP N  907                 -148.99                    
REMARK 500 GLY O  123     ASP O  124                  140.42                    
REMARK 500 ILE O  277     PRO O  278                   94.61                    
REMARK 500 LYS P   45     THR P   46                 -141.03                    
REMARK 500 GLU P  319     PRO P  320                  146.97                    
REMARK 500 THR Q  402     PRO Q  403                 -142.83                    
REMARK 500 GLY R  202     ASP R  203                  148.99                    
REMARK 500 ILE R  381     ASP R  382                  148.31                    
REMARK 500 VAL S  163     ILE S  164                 -139.81                    
REMARK 500 ILE T  228     VAL T  229                  146.91                    
REMARK 500 ALA T  243     ASP T  244                  133.19                    
REMARK 500 GLY U   91     TRP U   92                 -147.48                    
REMARK 500 VAL U  125     LYS U  126                  149.48                    
REMARK 500 THR U  153     PHE U  154                  149.18                    
REMARK 500 ILE U  161     GLU U  162                 -141.76                    
REMARK 500 LEU U  229     GLN U  230                  147.45                    
REMARK 500 PRO V   46     MET V   47                 -147.35                    
REMARK 500 TRP V  117     LEU V  118                 -147.88                    
REMARK 500 LEU V  216     HIS V  217                  145.56                    
REMARK 500 SER W   13     GLU W   14                  142.66                    
REMARK 500 PHE W   21     PRO W   22                 -140.45                    
REMARK 500 SER W   53     GLY W   54                  148.90                    
REMARK 500 LYS W   71     ILE W   72                  144.51                    
REMARK 500 ARG W  109     ILE W  110                  145.38                    
REMARK 500 THR W  168     SER W  169                  145.51                    
REMARK 500 THR W  175     PRO W  176                  145.57                    
REMARK 500 LEU W  181     TYR W  182                  144.18                    
REMARK 500 GLY X   13     VAL X   14                  147.74                    
REMARK 500 ILE X   27     PRO X   28                 -125.14                    
REMARK 500 ASP X  118     LYS X  119                 -142.43                    
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      56 NON CIS, NON-TRANS OMEGA OUTLIERS.            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500    ARG N 762         0.33    SIDE CHAIN                              
REMARK 500    ARG N 889         0.22    SIDE CHAIN                              
REMARK 500    ARG P  47         0.18    SIDE CHAIN                              
REMARK 500    TYR U 113         0.15    SIDE CHAIN                              
REMARK 500    HIS V 109         0.11    SIDE CHAIN                              
REMARK 500    ARG W 109         0.34    SIDE CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    ARG A  46         10.68                                           
REMARK 500    VAL H 280        -12.11                                           
REMARK 500    GLY L 257         10.37                                           
REMARK 500    ARG L 342        -10.46                                           
REMARK 500    MET M  58        -34.00                                           
REMARK 500    LEU M 251         17.79                                           
REMARK 500    TYR V 108        -10.59                                           
REMARK 500    THR V 283        -12.25                                           
REMARK 500    GLN W  38        -22.12                                           
REMARK 500    LEU W 153        -28.73                                           
REMARK 500    SER Z 134         10.74                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 700                                                                      
REMARK 700 SHEET                                                                
REMARK 700 DETERMINATION METHOD: AUTHOR PROVIDED.                               
REMARK 700 THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN               
REMARK 700 ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW,          
REMARK 700 TWO SHEETS ARE DEFINED.                                              
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-2595   RELATED DB: EMDB                              
REMARK 900 DEEP CLASSIFICATION OF A LARGE CRYO-EM DATASET DEFINES THE           
REMARK 900 CONFORMATIONAL LANDSCAPE OF THE 26S PROTEASOME                       
REMARK 900 RELATED ID: 4CR2   RELATED DB: PDB                                   
REMARK 900 DEEP CLASSIFICATION OF A LARGE CRYO-EM DATASET DEFINES THE           
REMARK 900 CONFORMATIONAL LANDSCAPE OF THE 26S PROTEASOME                       
REMARK 900 RELATED ID: 4CR4   RELATED DB: PDB                                   
REMARK 900 DEEP CLASSIFICATION OF A LARGE CRYO-EM DATASET DEFINES THE           
REMARK 900 CONFORMATIONAL LANDSCAPE OF THE 26S PROTEASOME                       
REMARK 999                                                                      
REMARK 999 SEQUENCE                                                             
REMARK 999 LYS 108 ARG CONFLICT IN CHAIN 5 IS DUE TO A MUTATION IN              
REMARK 999  THE STARTING MODEL PDB ENTRY 1RYP                                   
DBREF  4CR3 1  -19   196  UNP    P38624   PSB1_YEAST       1    215             
DBREF  4CR3 2  -28   232  UNP    P25043   PSB2_YEAST       1    261             
DBREF  4CR3 3   -9   196  UNP    P25451   PSB3_YEAST       1    205             
DBREF  4CR3 4   -1   197  UNP    P22141   PSB4_YEAST       1    198             
DBREF  4CR3 5  -74   212  UNP    P30656   PSB5_YEAST       1    287             
DBREF  4CR3 6  -28   213  UNP    P23724   PSB6_YEAST       1    241             
DBREF  4CR3 7  -41   225  UNP    P30657   PSB7_YEAST       1    266             
DBREF  4CR3 A    1   252  UNP    P21243   PSA1_YEAST       1    252             
DBREF  4CR3 B    1   250  UNP    P23639   PSA2_YEAST       1    250             
DBREF  4CR3 C    1   258  UNP    P23638   PSA3_YEAST       1    258             
DBREF  4CR3 D    1   254  UNP    P40303   PSA4_YEAST       1    254             
DBREF  4CR3 E    1   260  UNP    P32379   PSA5_YEAST       1    260             
DBREF  4CR3 F    1   234  UNP    P40302   PSA6_YEAST       1    234             
DBREF  4CR3 G    0   287  UNP    P21242   PSA7_YEAST       1    288             
DBREF  4CR3 H    1   467  UNP    P33299   PRS7_YEAST       1    467             
DBREF  4CR3 I    1   437  UNP    P40327   PRS4_YEAST       1    437             
DBREF  4CR3 J    1   405  UNP    Q01939   PRS8_YEAST       1    405             
DBREF  4CR3 K    1   428  UNP    P33298   PRS6B_YEAST      1    428             
DBREF  4CR3 L    1   437  UNP    P53549   PRS10_YEAST      1    437             
DBREF  4CR3 M    1   434  UNP    P33297   PRS6A_YEAST      1    434             
DBREF  4CR3 N    1   945  UNP    P32565   RPN2_YEAST       1    945             
DBREF  4CR3 O    1   393  UNP    Q04062   RPN9_YEAST       1    393             
DBREF  4CR3 P    1   445  UNP    Q12250   RPN5_YEAST       1    445             
DBREF  4CR3 Q    1   434  UNP    Q12377   RPN6_YEAST       1    434             
DBREF  4CR3 R    1   429  UNP    Q06103   RPN7_YEAST       1    429             
DBREF  4CR3 S    1   523  UNP    P40016   RPN3_YEAST       1    523             
DBREF  4CR3 T    1   274  UNP    P32496   RPN12_YEAST      1    274             
DBREF  4CR3 U    1   338  UNP    Q08723   RPN8_YEAST       1    338             
DBREF  4CR3 V    1   306  UNP    P43588   RPN11_YEAST      1    306             
DBREF  4CR3 W    1   268  UNP    P38886   RPN10_YEAST      1    268             
DBREF  4CR3 X    1   156  UNP    O13563   RPN13_YEAST      1    156             
DBREF  4CR3 Y    1    89  UNP    O94742   SEM1_YEAST       1     89             
DBREF  4CR3 Z    1   993  UNP    P38764   RPN1_YEAST       1    993             
SEQADV 4CR3 ARG 5   33  UNP  P30656    LYS   108 SEE REMARK 999                 
SEQRES   1 1  215  MET ASN GLY ILE GLN VAL ASP ILE ASN ARG LEU LYS LYS          
SEQRES   2 1  215  GLY GLU VAL SER LEU GLY THR SER ILE MET ALA VAL THR          
SEQRES   3 1  215  PHE LYS ASP GLY VAL ILE LEU GLY ALA ASP SER ARG THR          
SEQRES   4 1  215  THR THR GLY ALA TYR ILE ALA ASN ARG VAL THR ASP LYS          
SEQRES   5 1  215  LEU THR ARG VAL HIS ASP LYS ILE TRP CYS CYS ARG SER          
SEQRES   6 1  215  GLY SER ALA ALA ASP THR GLN ALA ILE ALA ASP ILE VAL          
SEQRES   7 1  215  GLN TYR HIS LEU GLU LEU TYR THR SER GLN TYR GLY THR          
SEQRES   8 1  215  PRO SER THR GLU THR ALA ALA SER VAL PHE LYS GLU LEU          
SEQRES   9 1  215  CYS TYR GLU ASN LYS ASP ASN LEU THR ALA GLY ILE ILE          
SEQRES  10 1  215  VAL ALA GLY TYR ASP ASP LYS ASN LYS GLY GLU VAL TYR          
SEQRES  11 1  215  THR ILE PRO LEU GLY GLY SER VAL HIS LYS LEU PRO TYR          
SEQRES  12 1  215  ALA ILE ALA GLY SER GLY SER THR PHE ILE TYR GLY TYR          
SEQRES  13 1  215  CYS ASP LYS ASN PHE ARG GLU ASN MET SER LYS GLU GLU          
SEQRES  14 1  215  THR VAL ASP PHE ILE LYS HIS SER LEU SER GLN ALA ILE          
SEQRES  15 1  215  LYS TRP ASP GLY SER SER GLY GLY VAL ILE ARG MET VAL          
SEQRES  16 1  215  VAL LEU THR ALA ALA GLY VAL GLU ARG LEU ILE PHE TYR          
SEQRES  17 1  215  PRO ASP GLU TYR GLU GLN LEU                                  
SEQRES   1 2  261  MET ALA GLY LEU SER PHE ASP ASN TYR GLN ARG ASN ASN          
SEQRES   2 2  261  PHE LEU ALA GLU ASN SER HIS THR GLN PRO LYS ALA THR          
SEQRES   3 2  261  SER THR GLY THR THR ILE VAL GLY VAL LYS PHE ASN ASN          
SEQRES   4 2  261  GLY VAL VAL ILE ALA ALA ASP THR ARG SER THR GLN GLY          
SEQRES   5 2  261  PRO ILE VAL ALA ASP LYS ASN CYS ALA LYS LEU HIS ARG          
SEQRES   6 2  261  ILE SER PRO LYS ILE TRP CYS ALA GLY ALA GLY THR ALA          
SEQRES   7 2  261  ALA ASP THR GLU ALA VAL THR GLN LEU ILE GLY SER ASN          
SEQRES   8 2  261  ILE GLU LEU HIS SER LEU TYR THR SER ARG GLU PRO ARG          
SEQRES   9 2  261  VAL VAL SER ALA LEU GLN MET LEU LYS GLN HIS LEU PHE          
SEQRES  10 2  261  LYS TYR GLN GLY HIS ILE GLY ALA TYR LEU ILE VAL ALA          
SEQRES  11 2  261  GLY VAL ASP PRO THR GLY SER HIS LEU PHE SER ILE HIS          
SEQRES  12 2  261  ALA HIS GLY SER THR ASP VAL GLY TYR TYR LEU SER LEU          
SEQRES  13 2  261  GLY SER GLY SER LEU ALA ALA MET ALA VAL LEU GLU SER          
SEQRES  14 2  261  HIS TRP LYS GLN ASP LEU THR LYS GLU GLU ALA ILE LYS          
SEQRES  15 2  261  LEU ALA SER ASP ALA ILE GLN ALA GLY ILE TRP ASN ASP          
SEQRES  16 2  261  LEU GLY SER GLY SER ASN VAL ASP VAL CYS VAL MET GLU          
SEQRES  17 2  261  ILE GLY LYS ASP ALA GLU TYR LEU ARG ASN TYR LEU THR          
SEQRES  18 2  261  PRO ASN VAL ARG GLU GLU LYS GLN LYS SER TYR LYS PHE          
SEQRES  19 2  261  PRO ARG GLY THR THR ALA VAL LEU LYS GLU SER ILE VAL          
SEQRES  20 2  261  ASN ILE CYS ASP ILE GLN GLU GLU GLN VAL ASP ILE THR          
SEQRES  21 2  261  ALA                                                          
SEQRES   1 3  205  MET SER ASP PRO SER SER ILE ASN GLY GLY ILE VAL VAL          
SEQRES   2 3  205  ALA MET THR GLY LYS ASP CYS VAL ALA ILE ALA CYS ASP          
SEQRES   3 3  205  LEU ARG LEU GLY SER GLN SER LEU GLY VAL SER ASN LYS          
SEQRES   4 3  205  PHE GLU LYS ILE PHE HIS TYR GLY HIS VAL PHE LEU GLY          
SEQRES   5 3  205  ILE THR GLY LEU ALA THR ASP VAL THR THR LEU ASN GLU          
SEQRES   6 3  205  MET PHE ARG TYR LYS THR ASN LEU TYR LYS LEU LYS GLU          
SEQRES   7 3  205  GLU ARG ALA ILE GLU PRO GLU THR PHE THR GLN LEU VAL          
SEQRES   8 3  205  SER SER SER LEU TYR GLU ARG ARG PHE GLY PRO TYR PHE          
SEQRES   9 3  205  VAL GLY PRO VAL VAL ALA GLY ILE ASN SER LYS SER GLY          
SEQRES  10 3  205  LYS PRO PHE ILE ALA GLY PHE ASP LEU ILE GLY CYS ILE          
SEQRES  11 3  205  ASP GLU ALA LYS ASP PHE ILE VAL SER GLY THR ALA SER          
SEQRES  12 3  205  ASP GLN LEU PHE GLY MET CYS GLU SER LEU TYR GLU PRO          
SEQRES  13 3  205  ASN LEU GLU PRO GLU ASP LEU PHE GLU THR ILE SER GLN          
SEQRES  14 3  205  ALA LEU LEU ASN ALA ALA ASP ARG ASP ALA LEU SER GLY          
SEQRES  15 3  205  TRP GLY ALA VAL VAL TYR ILE ILE LYS LYS ASP GLU VAL          
SEQRES  16 3  205  VAL LYS ARG TYR LEU LYS MET ARG GLN ASP                      
SEQRES   1 4  198  MET ASP ILE ILE LEU GLY ILE ARG VAL GLN ASP SER VAL          
SEQRES   2 4  198  ILE LEU ALA SER SER LYS ALA VAL THR ARG GLY ILE SER          
SEQRES   3 4  198  VAL LEU LYS ASP SER ASP ASP LYS THR ARG GLN LEU SER          
SEQRES   4 4  198  PRO HIS THR LEU MET SER PHE ALA GLY GLU ALA GLY ASP          
SEQRES   5 4  198  THR VAL GLN PHE ALA GLU TYR ILE GLN ALA ASN ILE GLN          
SEQRES   6 4  198  LEU TYR SER ILE ARG GLU ASP TYR GLU LEU SER PRO GLN          
SEQRES   7 4  198  ALA VAL SER SER PHE VAL ARG GLN GLU LEU ALA LYS SER          
SEQRES   8 4  198  ILE ARG SER ARG ARG PRO TYR GLN VAL ASN VAL LEU ILE          
SEQRES   9 4  198  GLY GLY TYR ASP LYS LYS LYS ASN LYS PRO GLU LEU TYR          
SEQRES  10 4  198  GLN ILE ASP TYR LEU GLY THR LYS VAL GLU LEU PRO TYR          
SEQRES  11 4  198  GLY ALA HIS GLY TYR SER GLY PHE TYR THR PHE SER LEU          
SEQRES  12 4  198  LEU ASP HIS HIS TYR ARG PRO ASP MET THR THR GLU GLU          
SEQRES  13 4  198  GLY LEU ASP LEU LEU LYS LEU CYS VAL GLN GLU LEU GLU          
SEQRES  14 4  198  LYS ARG MET PRO MET ASP PHE LYS GLY VAL ILE VAL LYS          
SEQRES  15 4  198  ILE VAL ASP LYS ASP GLY ILE ARG GLN VAL ASP ASP PHE          
SEQRES  16 4  198  GLN ALA GLN                                                  
SEQRES   1 5  287  MET GLN ALA ILE ALA ASP SER PHE SER VAL PRO ASN ARG          
SEQRES   2 5  287  LEU VAL LYS GLU LEU GLN TYR ASP ASN GLU GLN ASN LEU          
SEQRES   3 5  287  GLU SER ASP PHE VAL THR GLY ALA SER GLN PHE GLN ARG          
SEQRES   4 5  287  LEU ALA PRO SER LEU THR VAL PRO PRO ILE ALA SER PRO          
SEQRES   5 5  287  GLN GLN PHE LEU ARG ALA HIS THR ASP ASP SER ARG ASN          
SEQRES   6 5  287  PRO ASP CYS LYS ILE LYS ILE ALA HIS GLY THR THR THR          
SEQRES   7 5  287  LEU ALA PHE ARG PHE GLN GLY GLY ILE ILE VAL ALA VAL          
SEQRES   8 5  287  ASP SER ARG ALA THR ALA GLY ASN TRP VAL ALA SER GLN          
SEQRES   9 5  287  THR VAL LYS ARG VAL ILE GLU ILE ASN PRO PHE LEU LEU          
SEQRES  10 5  287  GLY THR MET ALA GLY GLY ALA ALA ASP CYS GLN PHE TRP          
SEQRES  11 5  287  GLU THR TRP LEU GLY SER GLN CYS ARG LEU HIS GLU LEU          
SEQRES  12 5  287  ARG GLU LYS GLU ARG ILE SER VAL ALA ALA ALA SER LYS          
SEQRES  13 5  287  ILE LEU SER ASN LEU VAL TYR GLN TYR LYS GLY ALA GLY          
SEQRES  14 5  287  LEU SER MET GLY THR MET ILE CYS GLY TYR THR ARG LYS          
SEQRES  15 5  287  GLU GLY PRO THR ILE TYR TYR VAL ASP SER ASP GLY THR          
SEQRES  16 5  287  ARG LEU LYS GLY ASP ILE PHE CYS VAL GLY SER GLY GLN          
SEQRES  17 5  287  THR PHE ALA TYR GLY VAL LEU ASP SER ASN TYR LYS TRP          
SEQRES  18 5  287  ASP LEU SER VAL GLU ASP ALA LEU TYR LEU GLY LYS ARG          
SEQRES  19 5  287  SER ILE LEU ALA ALA ALA HIS ARG ASP ALA TYR SER GLY          
SEQRES  20 5  287  GLY SER VAL ASN LEU TYR HIS VAL THR GLU ASP GLY TRP          
SEQRES  21 5  287  ILE TYR HIS GLY ASN HIS ASP VAL GLY GLU LEU PHE TRP          
SEQRES  22 5  287  LYS VAL LYS GLU GLU GLU GLY SER PHE ASN ASN VAL ILE          
SEQRES  23 5  287  GLY                                                          
SEQRES   1 6  241  MET ALA THR ILE ALA SER GLU TYR SER SER GLU ALA SER          
SEQRES   2 6  241  ASN THR PRO ILE GLU HIS GLN PHE ASN PRO TYR GLY ASP          
SEQRES   3 6  241  ASN GLY GLY THR ILE LEU GLY ILE ALA GLY GLU ASP PHE          
SEQRES   4 6  241  ALA VAL LEU ALA GLY ASP THR ARG ASN ILE THR ASP TYR          
SEQRES   5 6  241  SER ILE ASN SER ARG TYR GLU PRO LYS VAL PHE ASP CYS          
SEQRES   6 6  241  GLY ASP ASN ILE VAL MET SER ALA ASN GLY PHE ALA ALA          
SEQRES   7 6  241  ASP GLY ASP ALA LEU VAL LYS ARG PHE LYS ASN SER VAL          
SEQRES   8 6  241  LYS TRP TYR HIS PHE ASP HIS ASN ASP LYS LYS LEU SER          
SEQRES   9 6  241  ILE ASN SER ALA ALA ARG ASN ILE GLN HIS LEU LEU TYR          
SEQRES  10 6  241  GLY LYS ARG PHE PHE PRO TYR TYR VAL HIS THR ILE ILE          
SEQRES  11 6  241  ALA GLY LEU ASP GLU ASP GLY LYS GLY ALA VAL TYR SER          
SEQRES  12 6  241  PHE ASP PRO VAL GLY SER TYR GLU ARG GLU GLN CYS ARG          
SEQRES  13 6  241  ALA GLY GLY ALA ALA ALA SER LEU ILE MET PRO PHE LEU          
SEQRES  14 6  241  ASP ASN GLN VAL ASN PHE LYS ASN GLN TYR GLU PRO GLY          
SEQRES  15 6  241  THR ASN GLY LYS VAL LYS LYS PRO LEU LYS TYR LEU SER          
SEQRES  16 6  241  VAL GLU GLU VAL ILE LYS LEU VAL ARG ASP SER PHE THR          
SEQRES  17 6  241  SER ALA THR GLU ARG HIS ILE GLN VAL GLY ASP GLY LEU          
SEQRES  18 6  241  GLU ILE LEU ILE VAL THR LYS ASP GLY VAL ARG LYS GLU          
SEQRES  19 6  241  PHE TYR GLU LEU LYS ARG ASP                                  
SEQRES   1 7  266  MET ASN HIS ASP PRO PHE SER TRP GLY ARG PRO ALA ASP          
SEQRES   2 7  266  SER THR TYR GLY ALA TYR ASN THR GLN ILE ALA ASN ALA          
SEQRES   3 7  266  GLY ALA SER PRO MET VAL ASN THR GLN GLN PRO ILE VAL          
SEQRES   4 7  266  THR GLY THR SER VAL ILE SER MET LYS TYR ASP ASN GLY          
SEQRES   5 7  266  VAL ILE ILE ALA ALA ASP ASN LEU GLY SER TYR GLY SER          
SEQRES   6 7  266  LEU LEU ARG PHE ASN GLY VAL GLU ARG LEU ILE PRO VAL          
SEQRES   7 7  266  GLY ASP ASN THR VAL VAL GLY ILE SER GLY ASP ILE SER          
SEQRES   8 7  266  ASP MET GLN HIS ILE GLU ARG LEU LEU LYS ASP LEU VAL          
SEQRES   9 7  266  THR GLU ASN ALA TYR ASP ASN PRO LEU ALA ASP ALA GLU          
SEQRES  10 7  266  GLU ALA LEU GLU PRO SER TYR ILE PHE GLU TYR LEU ALA          
SEQRES  11 7  266  THR VAL MET TYR GLN ARG ARG SER LYS MET ASN PRO LEU          
SEQRES  12 7  266  TRP ASN ALA ILE ILE VAL ALA GLY VAL GLN SER ASN GLY          
SEQRES  13 7  266  ASP GLN PHE LEU ARG TYR VAL ASN LEU LEU GLY VAL THR          
SEQRES  14 7  266  TYR SER SER PRO THR LEU ALA THR GLY PHE GLY ALA HIS          
SEQRES  15 7  266  MET ALA ASN PRO LEU LEU ARG LYS VAL VAL ASP ARG GLU          
SEQRES  16 7  266  SER ASP ILE PRO LYS THR THR VAL GLN VAL ALA GLU GLU          
SEQRES  17 7  266  ALA ILE VAL ASN ALA MET ARG VAL LEU TYR TYR ARG ASP          
SEQRES  18 7  266  ALA ARG SER SER ARG ASN PHE SER LEU ALA ILE ILE ASP          
SEQRES  19 7  266  LYS ASN THR GLY LEU THR PHE LYS LYS ASN LEU GLN VAL          
SEQRES  20 7  266  GLU ASN MET LYS TRP ASP PHE ALA LYS ASP ILE LYS GLY          
SEQRES  21 7  266  TYR GLY THR GLN LYS ILE                                      
SEQRES   1 A  252  MET SER GLY ALA ALA ALA ALA SER ALA ALA GLY TYR ASP          
SEQRES   2 A  252  ARG HIS ILE THR ILE PHE SER PRO GLU GLY ARG LEU TYR          
SEQRES   3 A  252  GLN VAL GLU TYR ALA PHE LYS ALA THR ASN GLN THR ASN          
SEQRES   4 A  252  ILE ASN SER LEU ALA VAL ARG GLY LYS ASP CYS THR VAL          
SEQRES   5 A  252  VAL ILE SER GLN LYS LYS VAL PRO ASP LYS LEU LEU ASP          
SEQRES   6 A  252  PRO THR THR VAL SER TYR ILE PHE CYS ILE SER ARG THR          
SEQRES   7 A  252  ILE GLY MET VAL VAL ASN GLY PRO ILE PRO ASP ALA ARG          
SEQRES   8 A  252  ASN ALA ALA LEU ARG ALA LYS ALA GLU ALA ALA GLU PHE          
SEQRES   9 A  252  ARG TYR LYS TYR GLY TYR ASP MET PRO CYS ASP VAL LEU          
SEQRES  10 A  252  ALA LYS ARG MET ALA ASN LEU SER GLN ILE TYR THR GLN          
SEQRES  11 A  252  ARG ALA TYR MET ARG PRO LEU GLY VAL ILE LEU THR PHE          
SEQRES  12 A  252  VAL SER VAL ASP GLU GLU LEU GLY PRO SER ILE TYR LYS          
SEQRES  13 A  252  THR ASP PRO ALA GLY TYR TYR VAL GLY TYR LYS ALA THR          
SEQRES  14 A  252  ALA THR GLY PRO LYS GLN GLN GLU ILE THR THR ASN LEU          
SEQRES  15 A  252  GLU ASN HIS PHE LYS LYS SER LYS ILE ASP HIS ILE ASN          
SEQRES  16 A  252  GLU GLU SER TRP GLU LYS VAL VAL GLU PHE ALA ILE THR          
SEQRES  17 A  252  HIS MET ILE ASP ALA LEU GLY THR GLU PHE SER LYS ASN          
SEQRES  18 A  252  ASP LEU GLU VAL GLY VAL ALA THR LYS ASP LYS PHE PHE          
SEQRES  19 A  252  THR LEU SER ALA GLU ASN ILE GLU GLU ARG LEU VAL ALA          
SEQRES  20 A  252  ILE ALA GLU GLN ASP                                          
SEQRES   1 B  250  MET THR ASP ARG TYR SER PHE SER LEU THR THR PHE SER          
SEQRES   2 B  250  PRO SER GLY LYS LEU GLY GLN ILE ASP TYR ALA LEU THR          
SEQRES   3 B  250  ALA VAL LYS GLN GLY VAL THR SER LEU GLY ILE LYS ALA          
SEQRES   4 B  250  THR ASN GLY VAL VAL ILE ALA THR GLU LYS LYS SER SER          
SEQRES   5 B  250  SER PRO LEU ALA MET SER GLU THR LEU SER LYS VAL SER          
SEQRES   6 B  250  LEU LEU THR PRO ASP ILE GLY ALA VAL TYR SER GLY MET          
SEQRES   7 B  250  GLY PRO ASP TYR ARG VAL LEU VAL ASP LYS SER ARG LYS          
SEQRES   8 B  250  VAL ALA HIS THR SER TYR LYS ARG ILE TYR GLY GLU TYR          
SEQRES   9 B  250  PRO PRO THR LYS LEU LEU VAL SER GLU VAL ALA LYS ILE          
SEQRES  10 B  250  MET GLN GLU ALA THR GLN SER GLY GLY VAL ARG PRO PHE          
SEQRES  11 B  250  GLY VAL SER LEU LEU ILE ALA GLY HIS ASP GLU PHE ASN          
SEQRES  12 B  250  GLY PHE SER LEU TYR GLN VAL ASP PRO SER GLY SER TYR          
SEQRES  13 B  250  PHE PRO TRP LYS ALA THR ALA ILE GLY LYS GLY SER VAL          
SEQRES  14 B  250  ALA ALA LYS THR PHE LEU GLU LYS ARG TRP ASN ASP GLU          
SEQRES  15 B  250  LEU GLU LEU GLU ASP ALA ILE HIS ILE ALA LEU LEU THR          
SEQRES  16 B  250  LEU LYS GLU SER VAL GLU GLY GLU PHE ASN GLY ASP THR          
SEQRES  17 B  250  ILE GLU LEU ALA ILE ILE GLY ASP GLU ASN PRO ASP LEU          
SEQRES  18 B  250  LEU GLY TYR THR GLY ILE PRO THR ASP LYS GLY PRO ARG          
SEQRES  19 B  250  PHE ARG LYS LEU THR SER GLN GLU ILE ASN ASP ARG LEU          
SEQRES  20 B  250  GLU ALA LEU                                                  
SEQRES   1 C  258  MET GLY SER ARG ARG TYR ASP SER ARG THR THR ILE PHE          
SEQRES   2 C  258  SER PRO GLU GLY ARG LEU TYR GLN VAL GLU TYR ALA LEU          
SEQRES   3 C  258  GLU SER ILE SER HIS ALA GLY THR ALA ILE GLY ILE MET          
SEQRES   4 C  258  ALA SER ASP GLY ILE VAL LEU ALA ALA GLU ARG LYS VAL          
SEQRES   5 C  258  THR SER THR LEU LEU GLU GLN ASP THR SER THR GLU LYS          
SEQRES   6 C  258  LEU TYR LYS LEU ASN ASP LYS ILE ALA VAL ALA VAL ALA          
SEQRES   7 C  258  GLY LEU THR ALA ASP ALA GLU ILE LEU ILE ASN THR ALA          
SEQRES   8 C  258  ARG ILE HIS ALA GLN ASN TYR LEU LYS THR TYR ASN GLU          
SEQRES   9 C  258  ASP ILE PRO VAL GLU ILE LEU VAL ARG ARG LEU SER ASP          
SEQRES  10 C  258  ILE LYS GLN GLY TYR THR GLN HIS GLY GLY LEU ARG PRO          
SEQRES  11 C  258  PHE GLY VAL SER PHE ILE TYR ALA GLY TYR ASP ASP ARG          
SEQRES  12 C  258  TYR GLY TYR GLN LEU TYR THR SER ASN PRO SER GLY ASN          
SEQRES  13 C  258  TYR THR GLY TRP LYS ALA ILE SER VAL GLY ALA ASN THR          
SEQRES  14 C  258  SER ALA ALA GLN THR LEU LEU GLN MET ASP TYR LYS ASP          
SEQRES  15 C  258  ASP MET LYS VAL ASP ASP ALA ILE GLU LEU ALA LEU LYS          
SEQRES  16 C  258  THR LEU SER LYS THR THR ASP SER SER ALA LEU THR TYR          
SEQRES  17 C  258  ASP ARG LEU GLU PHE ALA THR ILE ARG LYS GLY ALA ASN          
SEQRES  18 C  258  ASP GLY GLU VAL TYR GLN LYS ILE PHE LYS PRO GLN GLU          
SEQRES  19 C  258  ILE LYS ASP ILE LEU VAL LYS THR GLY ILE THR LYS LYS          
SEQRES  20 C  258  ASP GLU ASP GLU GLU ALA ASP GLU ASP MET LYS                  
SEQRES   1 D  254  MET SER GLY TYR ASP ARG ALA LEU SER ILE PHE SER PRO          
SEQRES   2 D  254  ASP GLY HIS ILE PHE GLN VAL GLU TYR ALA LEU GLU ALA          
SEQRES   3 D  254  VAL LYS ARG GLY THR CYS ALA VAL GLY VAL LYS GLY LYS          
SEQRES   4 D  254  ASN CYS VAL VAL LEU GLY CYS GLU ARG ARG SER THR LEU          
SEQRES   5 D  254  LYS LEU GLN ASP THR ARG ILE THR PRO SER LYS VAL SER          
SEQRES   6 D  254  LYS ILE ASP SER HIS VAL VAL LEU SER PHE SER GLY LEU          
SEQRES   7 D  254  ASN ALA ASP SER ARG ILE LEU ILE GLU LYS ALA ARG VAL          
SEQRES   8 D  254  GLU ALA GLN SER HIS ARG LEU THR LEU GLU ASP PRO VAL          
SEQRES   9 D  254  THR VAL GLU TYR LEU THR ARG TYR VAL ALA GLY VAL GLN          
SEQRES  10 D  254  GLN ARG TYR THR GLN SER GLY GLY VAL ARG PRO PHE GLY          
SEQRES  11 D  254  VAL SER THR LEU ILE ALA GLY PHE ASP PRO ARG ASP ASP          
SEQRES  12 D  254  GLU PRO LYS LEU TYR GLN THR GLU PRO SER GLY ILE TYR          
SEQRES  13 D  254  SER SER TRP SER ALA GLN THR ILE GLY ARG ASN SER LYS          
SEQRES  14 D  254  THR VAL ARG GLU PHE LEU GLU LYS ASN TYR ASP ARG LYS          
SEQRES  15 D  254  GLU PRO PRO ALA THR VAL GLU GLU CYS VAL LYS LEU THR          
SEQRES  16 D  254  VAL ARG SER LEU LEU GLU VAL VAL GLN THR GLY ALA LYS          
SEQRES  17 D  254  ASN ILE GLU ILE THR VAL VAL LYS PRO ASP SER ASP ILE          
SEQRES  18 D  254  VAL ALA LEU SER SER GLU GLU ILE ASN GLN TYR VAL THR          
SEQRES  19 D  254  GLN ILE GLU GLN GLU LYS GLN GLU GLN GLN GLU GLN ASP          
SEQRES  20 D  254  LYS LYS LYS LYS SER ASN HIS                                  
SEQRES   1 E  260  MET PHE LEU THR ARG SER GLU TYR ASP ARG GLY VAL SER          
SEQRES   2 E  260  THR PHE SER PRO GLU GLY ARG LEU PHE GLN VAL GLU TYR          
SEQRES   3 E  260  SER LEU GLU ALA ILE LYS LEU GLY SER THR ALA ILE GLY          
SEQRES   4 E  260  ILE ALA THR LYS GLU GLY VAL VAL LEU GLY VAL GLU LYS          
SEQRES   5 E  260  ARG ALA THR SER PRO LEU LEU GLU SER ASP SER ILE GLU          
SEQRES   6 E  260  LYS ILE VAL GLU ILE ASP ARG HIS ILE GLY CYS ALA MET          
SEQRES   7 E  260  SER GLY LEU THR ALA ASP ALA ARG SER MET ILE GLU HIS          
SEQRES   8 E  260  ALA ARG THR ALA ALA VAL THR HIS ASN LEU TYR TYR ASP          
SEQRES   9 E  260  GLU ASP ILE ASN VAL GLU SER LEU THR GLN SER VAL CYS          
SEQRES  10 E  260  ASP LEU ALA LEU ARG PHE GLY GLU GLY ALA SER GLY GLU          
SEQRES  11 E  260  GLU ARG LEU MET SER ARG PRO PHE GLY VAL ALA LEU LEU          
SEQRES  12 E  260  ILE ALA GLY HIS ASP ALA ASP ASP GLY TYR GLN LEU PHE          
SEQRES  13 E  260  HIS ALA GLU PRO SER GLY THR PHE TYR ARG TYR ASN ALA          
SEQRES  14 E  260  LYS ALA ILE GLY SER GLY SER GLU GLY ALA GLN ALA GLU          
SEQRES  15 E  260  LEU LEU ASN GLU TRP HIS SER SER LEU THR LEU LYS GLU          
SEQRES  16 E  260  ALA GLU LEU LEU VAL LEU LYS ILE LEU LYS GLN VAL MET          
SEQRES  17 E  260  GLU GLU LYS LEU ASP GLU ASN ASN ALA GLN LEU SER CYS          
SEQRES  18 E  260  ILE THR LYS GLN ASP GLY PHE LYS ILE TYR ASP ASN GLU          
SEQRES  19 E  260  LYS THR ALA GLU LEU ILE LYS GLU LEU LYS GLU LYS GLU          
SEQRES  20 E  260  ALA ALA GLU SER PRO GLU GLU ALA ASP VAL GLU MET SER          
SEQRES   1 F  234  MET PHE ARG ASN ASN TYR ASP GLY ASP THR VAL THR PHE          
SEQRES   2 F  234  SER PRO THR GLY ARG LEU PHE GLN VAL GLU TYR ALA LEU          
SEQRES   3 F  234  GLU ALA ILE LYS GLN GLY SER VAL THR VAL GLY LEU ARG          
SEQRES   4 F  234  SER ASN THR HIS ALA VAL LEU VAL ALA LEU LYS ARG ASN          
SEQRES   5 F  234  ALA ASP GLU LEU SER SER TYR GLN LYS LYS ILE ILE LYS          
SEQRES   6 F  234  CYS ASP GLU HIS MET GLY LEU SER LEU ALA GLY LEU ALA          
SEQRES   7 F  234  PRO ASP ALA ARG VAL LEU SER ASN TYR LEU ARG GLN GLN          
SEQRES   8 F  234  CYS ASN TYR SER SER LEU VAL PHE ASN ARG LYS LEU ALA          
SEQRES   9 F  234  VAL GLU ARG ALA GLY HIS LEU LEU CYS ASP LYS ALA GLN          
SEQRES  10 F  234  LYS ASN THR GLN SER TYR GLY GLY ARG PRO TYR GLY VAL          
SEQRES  11 F  234  GLY LEU LEU ILE ILE GLY TYR ASP LYS SER GLY ALA HIS          
SEQRES  12 F  234  LEU LEU GLU PHE GLN PRO SER GLY ASN VAL THR GLU LEU          
SEQRES  13 F  234  TYR GLY THR ALA ILE GLY ALA ARG SER GLN GLY ALA LYS          
SEQRES  14 F  234  THR TYR LEU GLU ARG THR LEU ASP THR PHE ILE LYS ILE          
SEQRES  15 F  234  ASP GLY ASN PRO ASP GLU LEU ILE LYS ALA GLY VAL GLU          
SEQRES  16 F  234  ALA ILE SER GLN SER LEU ARG ASP GLU SER LEU THR VAL          
SEQRES  17 F  234  ASP ASN LEU SER ILE ALA ILE VAL GLY LYS ASP THR PRO          
SEQRES  18 F  234  PHE THR ILE TYR ASP GLY GLU ALA VAL ALA LYS TYR ILE          
SEQRES   1 G  288  MET THR SER ILE GLY THR GLY TYR ASP LEU SER ASN SER          
SEQRES   2 G  288  VAL PHE SER PRO ASP GLY ARG ASN PHE GLN VAL GLU TYR          
SEQRES   3 G  288  ALA VAL LYS ALA VAL GLU ASN GLY THR THR SER ILE GLY          
SEQRES   4 G  288  ILE LYS CYS ASN ASP GLY VAL VAL PHE ALA VAL GLU LYS          
SEQRES   5 G  288  LEU ILE THR SER LYS LEU LEU VAL PRO GLN LYS ASN VAL          
SEQRES   6 G  288  LYS ILE GLN VAL VAL ASP ARG HIS ILE GLY CYS VAL TYR          
SEQRES   7 G  288  SER GLY LEU ILE PRO ASP GLY ARG HIS LEU VAL ASN ARG          
SEQRES   8 G  288  GLY ARG GLU GLU ALA ALA SER PHE LYS LYS LEU TYR LYS          
SEQRES   9 G  288  THR PRO ILE PRO ILE PRO ALA PHE ALA ASP ARG LEU GLY          
SEQRES  10 G  288  GLN TYR VAL GLN ALA HIS THR LEU TYR ASN SER VAL ARG          
SEQRES  11 G  288  PRO PHE GLY VAL SER THR ILE PHE GLY GLY VAL ASP LYS          
SEQRES  12 G  288  ASN GLY ALA HIS LEU TYR MET LEU GLU PRO SER GLY SER          
SEQRES  13 G  288  TYR TRP GLY TYR LYS GLY ALA ALA THR GLY LYS GLY ARG          
SEQRES  14 G  288  GLN SER ALA LYS ALA GLU LEU GLU LYS LEU VAL ASP HIS          
SEQRES  15 G  288  HIS PRO GLU GLY LEU SER ALA ARG GLU ALA VAL LYS GLN          
SEQRES  16 G  288  ALA ALA LYS ILE ILE TYR LEU ALA HIS GLU ASP ASN LYS          
SEQRES  17 G  288  GLU LYS ASP PHE GLU LEU GLU ILE SER TRP CYS SER LEU          
SEQRES  18 G  288  SER GLU THR ASN GLY LEU HIS LYS PHE VAL LYS GLY ASP          
SEQRES  19 G  288  LEU LEU GLN GLU ALA ILE ASP PHE ALA GLN LYS GLU ILE          
SEQRES  20 G  288  ASN GLY ASP ASP ASP GLU ASP GLU ASP ASP SER ASP ASN          
SEQRES  21 G  288  VAL MET SER SER ASP ASP GLU ASN ALA PRO VAL ALA THR          
SEQRES  22 G  288  ASN ALA ASN ALA THR THR ASP GLN GLU GLY ASP ILE HIS          
SEQRES  23 G  288  LEU GLU                                                      
SEQRES   1 H  467  MET PRO PRO LYS GLU ASP TRP GLU LYS TYR LYS ALA PRO          
SEQRES   2 H  467  LEU GLU ASP ASP ASP LYS LYS PRO ASP ASP ASP LYS ILE          
SEQRES   3 H  467  VAL PRO LEU THR GLU GLY ASP ILE GLN VAL LEU LYS SER          
SEQRES   4 H  467  TYR GLY ALA ALA PRO TYR ALA ALA LYS LEU LYS GLN THR          
SEQRES   5 H  467  GLU ASN ASP LEU LYS ASP ILE GLU ALA ARG ILE LYS GLU          
SEQRES   6 H  467  LYS ALA GLY VAL LYS GLU SER ASP THR GLY LEU ALA PRO          
SEQRES   7 H  467  SER HIS LEU TRP ASP ILE MET GLY ASP ARG GLN ARG LEU          
SEQRES   8 H  467  GLY GLU GLU HIS PRO LEU GLN VAL ALA ARG CYS THR LYS          
SEQRES   9 H  467  ILE ILE LYS GLY ASN GLY GLU SER ASP GLU THR THR THR          
SEQRES  10 H  467  ASP ASN ASN ASN SER GLY ASN SER ASN SER ASN SER ASN          
SEQRES  11 H  467  GLN GLN SER THR ASP ALA ASP GLU ASP ASP GLU ASP ALA          
SEQRES  12 H  467  LYS TYR VAL ILE ASN LEU LYS GLN ILE ALA LYS PHE VAL          
SEQRES  13 H  467  VAL GLY LEU GLY GLU ARG VAL SER PRO THR ASP ILE GLU          
SEQRES  14 H  467  GLU GLY MET ARG VAL GLY VAL ASP ARG SER LYS TYR ASN          
SEQRES  15 H  467  ILE GLU LEU PRO LEU PRO PRO ARG ILE ASP PRO SER VAL          
SEQRES  16 H  467  THR MET MET THR VAL GLU GLU LYS PRO ASP VAL THR TYR          
SEQRES  17 H  467  SER ASP VAL GLY GLY CYS LYS ASP GLN ILE GLU LYS LEU          
SEQRES  18 H  467  ARG GLU VAL VAL GLU LEU PRO LEU LEU SER PRO GLU ARG          
SEQRES  19 H  467  PHE ALA THR LEU GLY ILE ASP PRO PRO LYS GLY ILE LEU          
SEQRES  20 H  467  LEU TYR GLY PRO PRO GLY THR GLY LYS THR LEU CYS ALA          
SEQRES  21 H  467  ARG ALA VAL ALA ASN ARG THR ASP ALA THR PHE ILE ARG          
SEQRES  22 H  467  VAL ILE GLY SER GLU LEU VAL GLN LYS TYR VAL GLY GLU          
SEQRES  23 H  467  GLY ALA ARG MET VAL ARG GLU LEU PHE GLU MET ALA ARG          
SEQRES  24 H  467  THR LYS LYS ALA CYS ILE ILE PHE PHE ASP GLU ILE ASP          
SEQRES  25 H  467  ALA VAL GLY GLY ALA ARG PHE ASP ASP GLY ALA GLY GLY          
SEQRES  26 H  467  ASP ASN GLU VAL GLN ARG THR MET LEU GLU LEU ILE THR          
SEQRES  27 H  467  GLN LEU ASP GLY PHE ASP PRO ARG GLY ASN ILE LYS VAL          
SEQRES  28 H  467  MET PHE ALA THR ASN ARG PRO ASN THR LEU ASP PRO ALA          
SEQRES  29 H  467  LEU LEU ARG PRO GLY ARG ILE ASP ARG LYS VAL GLU PHE          
SEQRES  30 H  467  SER LEU PRO ASP LEU GLU GLY ARG ALA ASN ILE PHE ARG          
SEQRES  31 H  467  ILE HIS SER LYS SER MET SER VAL GLU ARG GLY ILE ARG          
SEQRES  32 H  467  TRP GLU LEU ILE SER ARG LEU CYS PRO ASN SER THR GLY          
SEQRES  33 H  467  ALA GLU LEU ARG SER VAL CYS THR GLU ALA GLY MET PHE          
SEQRES  34 H  467  ALA ILE ARG ALA ARG ARG LYS VAL ALA THR GLU LYS ASP          
SEQRES  35 H  467  PHE LEU LYS ALA VAL ASP LYS VAL ILE SER GLY TYR LYS          
SEQRES  36 H  467  LYS PHE SER SER THR SER ARG TYR MET GLN TYR ASN              
SEQRES   1 I  437  MET GLY GLN GLY VAL SER SER GLY GLN ASP LYS LYS LYS          
SEQRES   2 I  437  LYS LYS GLY SER ASN GLN LYS PRO LYS TYR GLU PRO PRO          
SEQRES   3 I  437  VAL GLN SER LYS PHE GLY ARG LYS LYS ARG LYS GLY GLY          
SEQRES   4 I  437  PRO ALA THR ALA GLU LYS LEU PRO ASN ILE TYR PRO SER          
SEQRES   5 I  437  THR ARG CYS LYS LEU LYS LEU LEU ARG MET GLU ARG ILE          
SEQRES   6 I  437  LYS ASP HIS LEU LEU LEU GLU GLU GLU PHE VAL SER ASN          
SEQRES   7 I  437  SER GLU ILE LEU LYS PRO PHE GLU LYS LYS GLN GLU GLU          
SEQRES   8 I  437  GLU LYS LYS GLN LEU GLU GLU ILE ARG GLY ASN PRO LEU          
SEQRES   9 I  437  SER ILE GLY THR LEU GLU GLU ILE ILE ASP ASP ASP HIS          
SEQRES  10 I  437  ALA ILE VAL THR SER PRO THR MET PRO ASP TYR TYR VAL          
SEQRES  11 I  437  SER ILE LEU SER PHE VAL ASP LYS GLU LEU LEU GLU PRO          
SEQRES  12 I  437  GLY CYS SER VAL LEU LEU HIS HIS LYS THR MET SER ILE          
SEQRES  13 I  437  VAL GLY VAL LEU GLN ASP ASP ALA ASP PRO MET VAL SER          
SEQRES  14 I  437  VAL MET LYS MET ASP LYS SER PRO THR GLU SER TYR SER          
SEQRES  15 I  437  ASP ILE GLY GLY LEU GLU SER GLN ILE GLN GLU ILE LYS          
SEQRES  16 I  437  GLU SER VAL GLU LEU PRO LEU THR HIS PRO GLU LEU TYR          
SEQRES  17 I  437  GLU GLU MET GLY ILE LYS PRO PRO LYS GLY VAL ILE LEU          
SEQRES  18 I  437  TYR GLY ALA PRO GLY THR GLY LYS THR LEU LEU ALA LYS          
SEQRES  19 I  437  ALA VAL ALA ASN GLN THR SER ALA THR PHE LEU ARG ILE          
SEQRES  20 I  437  VAL GLY SER GLU LEU ILE GLN LYS TYR LEU GLY ASP GLY          
SEQRES  21 I  437  PRO ARG LEU CYS ARG GLN ILE PHE LYS VAL ALA GLY GLU          
SEQRES  22 I  437  ASN ALA PRO SER ILE VAL PHE ILE ASP GLU ILE ASP ALA          
SEQRES  23 I  437  ILE GLY THR LYS ARG TYR ASP SER ASN SER GLY GLY GLU          
SEQRES  24 I  437  ARG GLU ILE GLN ARG THR MET LEU GLU LEU LEU ASN GLN          
SEQRES  25 I  437  LEU ASP GLY PHE ASP ASP ARG GLY ASP VAL LYS VAL ILE          
SEQRES  26 I  437  MET ALA THR ASN LYS ILE GLU THR LEU ASP PRO ALA LEU          
SEQRES  27 I  437  ILE ARG PRO GLY ARG ILE ASP ARG LYS ILE LEU PHE GLU          
SEQRES  28 I  437  ASN PRO ASP LEU SER THR LYS LYS LYS ILE LEU GLY ILE          
SEQRES  29 I  437  HIS THR SER LYS MET ASN LEU SER GLU ASP VAL ASN LEU          
SEQRES  30 I  437  GLU THR LEU VAL THR THR LYS ASP ASP LEU SER GLY ALA          
SEQRES  31 I  437  ASP ILE GLN ALA MET CYS THR GLU ALA GLY LEU LEU ALA          
SEQRES  32 I  437  LEU ARG GLU ARG ARG MET GLN VAL THR ALA GLU ASP PHE          
SEQRES  33 I  437  LYS GLN ALA LYS GLU ARG VAL MET LYS ASN LYS VAL GLU          
SEQRES  34 I  437  GLU ASN LEU GLU GLY LEU TYR LEU                              
SEQRES   1 J  405  MET THR ALA ALA VAL THR SER SER ASN ILE VAL LEU GLU          
SEQRES   2 J  405  THR HIS GLU SER GLY ILE LYS PRO TYR PHE GLU GLN LYS          
SEQRES   3 J  405  ILE GLN GLU THR GLU LEU LYS ILE ARG SER LYS THR GLU          
SEQRES   4 J  405  ASN VAL ARG ARG LEU GLU ALA GLN ARG ASN ALA LEU ASN          
SEQRES   5 J  405  ASP LYS VAL ARG PHE ILE LYS ASP GLU LEU ARG LEU LEU          
SEQRES   6 J  405  GLN GLU PRO GLY SER TYR VAL GLY GLU VAL ILE LYS ILE          
SEQRES   7 J  405  VAL SER ASP LYS LYS VAL LEU VAL LYS VAL GLN PRO GLU          
SEQRES   8 J  405  GLY LYS TYR ILE VAL ASP VAL ALA LYS ASP ILE ASN VAL          
SEQRES   9 J  405  LYS ASP LEU LYS ALA SER GLN ARG VAL CYS LEU ARG SER          
SEQRES  10 J  405  ASP SER TYR MET LEU HIS LYS VAL LEU GLU ASN LYS ALA          
SEQRES  11 J  405  ASP PRO LEU VAL SER LEU MET MET VAL GLU LYS VAL PRO          
SEQRES  12 J  405  ASP SER THR TYR ASP MET VAL GLY GLY LEU THR LYS GLN          
SEQRES  13 J  405  ILE LYS GLU ILE LYS GLU VAL ILE GLU LEU PRO VAL LYS          
SEQRES  14 J  405  HIS PRO GLU LEU PHE GLU SER LEU GLY ILE ALA GLN PRO          
SEQRES  15 J  405  LYS GLY VAL ILE LEU TYR GLY PRO PRO GLY THR GLY LYS          
SEQRES  16 J  405  THR LEU LEU ALA ARG ALA VAL ALA HIS HIS THR ASP CYS          
SEQRES  17 J  405  LYS PHE ILE ARG VAL SER GLY ALA GLU LEU VAL GLN LYS          
SEQRES  18 J  405  TYR ILE GLY GLU GLY SER ARG MET VAL ARG GLU LEU PHE          
SEQRES  19 J  405  VAL MET ALA ARG GLU HIS ALA PRO SER ILE ILE PHE MET          
SEQRES  20 J  405  ASP GLU ILE ASP SER ILE GLY SER THR ARG VAL GLU GLY          
SEQRES  21 J  405  SER GLY GLY GLY ASP SER GLU VAL GLN ARG THR MET LEU          
SEQRES  22 J  405  GLU LEU LEU ASN GLN LEU ASP GLY PHE GLU THR SER LYS          
SEQRES  23 J  405  ASN ILE LYS ILE ILE MET ALA THR ASN ARG LEU ASP ILE          
SEQRES  24 J  405  LEU ASP PRO ALA LEU LEU ARG PRO GLY ARG ILE ASP ARG          
SEQRES  25 J  405  LYS ILE GLU PHE PRO PRO PRO SER VAL ALA ALA ARG ALA          
SEQRES  26 J  405  GLU ILE LEU ARG ILE HIS SER ARG LYS MET ASN LEU THR          
SEQRES  27 J  405  ARG GLY ILE ASN LEU ARG LYS VAL ALA GLU LYS MET ASN          
SEQRES  28 J  405  GLY CYS SER GLY ALA ASP VAL LYS GLY VAL CYS THR GLU          
SEQRES  29 J  405  ALA GLY MET TYR ALA LEU ARG GLU ARG ARG ILE HIS VAL          
SEQRES  30 J  405  THR GLN GLU ASP PHE GLU LEU ALA VAL GLY LYS VAL MET          
SEQRES  31 J  405  ASN LYS ASN GLN GLU THR ALA ILE SER VAL ALA LYS LEU          
SEQRES  32 J  405  PHE LYS                                                      
SEQRES   1 K  428  MET GLU GLU LEU GLY ILE VAL THR PRO VAL GLU LYS ALA          
SEQRES   2 K  428  VAL GLU GLU LYS PRO ALA VAL LYS SER TYR ALA SER LEU          
SEQRES   3 K  428  LEU ALA GLN LEU ASN GLY THR VAL ASN ASN ASN SER ALA          
SEQRES   4 K  428  LEU SER ASN VAL ASN SER ASP ILE TYR PHE LYS LEU LYS          
SEQRES   5 K  428  LYS LEU GLU LYS GLU TYR GLU LEU LEU THR LEU GLN GLU          
SEQRES   6 K  428  ASP TYR ILE LYS ASP GLU GLN ARG HIS LEU LYS ARG GLU          
SEQRES   7 K  428  LEU LYS ARG ALA GLN GLU GLU VAL LYS ARG ILE GLN SER          
SEQRES   8 K  428  VAL PRO LEU VAL ILE GLY GLN PHE LEU GLU PRO ILE ASP          
SEQRES   9 K  428  GLN ASN THR GLY ILE VAL SER SER THR THR GLY MET SER          
SEQRES  10 K  428  TYR VAL VAL ARG ILE LEU SER THR LEU ASP ARG GLU LEU          
SEQRES  11 K  428  LEU LYS PRO SER MET SER VAL ALA LEU HIS ARG HIS SER          
SEQRES  12 K  428  ASN ALA LEU VAL ASP ILE LEU PRO PRO ASP SER ASP SER          
SEQRES  13 K  428  SER ILE SER VAL MET GLY GLU ASN GLU LYS PRO ASP VAL          
SEQRES  14 K  428  THR TYR ALA ASP VAL GLY GLY LEU ASP MET GLN LYS GLN          
SEQRES  15 K  428  GLU ILE ARG GLU ALA VAL GLU LEU PRO LEU VAL GLN ALA          
SEQRES  16 K  428  ASP LEU TYR GLU GLN ILE GLY ILE ASP PRO PRO ARG GLY          
SEQRES  17 K  428  VAL LEU LEU TYR GLY PRO PRO GLY THR GLY LYS THR MET          
SEQRES  18 K  428  LEU VAL LYS ALA VAL ALA ASN SER THR LYS ALA ALA PHE          
SEQRES  19 K  428  ILE ARG VAL ASN GLY SER GLU PHE VAL HIS LYS TYR LEU          
SEQRES  20 K  428  GLY GLU GLY PRO ARG MET VAL ARG ASP VAL PHE ARG LEU          
SEQRES  21 K  428  ALA ARG GLU ASN ALA PRO SER ILE ILE PHE ILE ASP GLU          
SEQRES  22 K  428  VAL ASP SER ILE ALA THR LYS ARG PHE ASP ALA GLN THR          
SEQRES  23 K  428  GLY SER ASP ARG GLU VAL GLN ARG ILE LEU ILE GLU LEU          
SEQRES  24 K  428  LEU THR GLN MET ASP GLY PHE ASP GLN SER THR ASN VAL          
SEQRES  25 K  428  LYS VAL ILE MET ALA THR ASN ARG ALA ASP THR LEU ASP          
SEQRES  26 K  428  PRO ALA LEU LEU ARG PRO GLY ARG LEU ASP ARG LYS ILE          
SEQRES  27 K  428  GLU PHE PRO SER LEU ARG ASP ARG ARG GLU ARG ARG LEU          
SEQRES  28 K  428  ILE PHE GLY THR ILE ALA SER LYS MET SER LEU ALA PRO          
SEQRES  29 K  428  GLU ALA ASP LEU ASP SER LEU ILE ILE ARG ASN ASP SER          
SEQRES  30 K  428  LEU SER GLY ALA VAL ILE ALA ALA ILE MET GLN GLU ALA          
SEQRES  31 K  428  GLY LEU ARG ALA VAL ARG LYS ASN ARG TYR VAL ILE LEU          
SEQRES  32 K  428  GLN SER ASP LEU GLU GLU ALA TYR ALA THR GLN VAL LYS          
SEQRES  33 K  428  THR ASP ASN THR VAL ASP LYS PHE ASP PHE TYR LYS              
SEQRES   1 L  437  MET SER GLU GLU GLN ASP PRO LEU LEU ALA GLY LEU GLY          
SEQRES   2 L  437  GLU THR SER GLY ASP ASN HIS THR GLN GLN SER HIS GLU          
SEQRES   3 L  437  GLN GLN PRO GLU GLN PRO GLN GLU THR GLU GLU HIS HIS          
SEQRES   4 L  437  GLU GLU GLU PRO SER ARG VAL ASP PRO GLU GLN GLU ALA          
SEQRES   5 L  437  HIS ASN LYS ALA LEU ASN GLN PHE LYS ARG LYS LEU LEU          
SEQRES   6 L  437  GLU HIS ARG ARG TYR ASP ASP GLN LEU LYS GLN ARG ARG          
SEQRES   7 L  437  GLN ASN ILE ARG ASP LEU GLU LYS LEU TYR ASP LYS THR          
SEQRES   8 L  437  GLU ASN ASP ILE LYS ALA LEU GLN SER ILE GLY GLN LEU          
SEQRES   9 L  437  ILE GLY GLU VAL MET LYS GLU LEU SER GLU GLU LYS TYR          
SEQRES  10 L  437  ILE VAL LYS ALA SER SER GLY PRO ARG TYR ILE VAL GLY          
SEQRES  11 L  437  VAL ARG ASN SER VAL ASP ARG SER LYS LEU LYS LYS GLY          
SEQRES  12 L  437  VAL ARG VAL THR LEU ASP ILE THR THR LEU THR ILE MET          
SEQRES  13 L  437  ARG ILE LEU PRO ARG GLU THR ASP PRO LEU VAL TYR ASN          
SEQRES  14 L  437  MET THR SER PHE GLU GLN GLY GLU ILE THR PHE ASP GLY          
SEQRES  15 L  437  ILE GLY GLY LEU THR GLU GLN ILE ARG GLU LEU ARG GLU          
SEQRES  16 L  437  VAL ILE GLU LEU PRO LEU LYS ASN PRO GLU ILE PHE GLN          
SEQRES  17 L  437  ARG VAL GLY ILE LYS PRO PRO LYS GLY VAL LEU LEU TYR          
SEQRES  18 L  437  GLY PRO PRO GLY THR GLY LYS THR LEU LEU ALA LYS ALA          
SEQRES  19 L  437  VAL ALA ALA THR ILE GLY ALA ASN PHE ILE PHE SER PRO          
SEQRES  20 L  437  ALA SER GLY ILE VAL ASP LYS TYR ILE GLY GLU SER ALA          
SEQRES  21 L  437  ARG ILE ILE ARG GLU MET PHE ALA TYR ALA LYS GLU HIS          
SEQRES  22 L  437  GLU PRO CYS ILE ILE PHE MET ASP GLU VAL ASP ALA ILE          
SEQRES  23 L  437  GLY GLY ARG ARG PHE SER GLU GLY THR SER ALA ASP ARG          
SEQRES  24 L  437  GLU ILE GLN ARG THR LEU MET GLU LEU LEU THR GLN MET          
SEQRES  25 L  437  ASP GLY PHE ASP ASN LEU GLY GLN THR LYS ILE ILE MET          
SEQRES  26 L  437  ALA THR ASN ARG PRO ASP THR LEU ASP PRO ALA LEU LEU          
SEQRES  27 L  437  ARG PRO GLY ARG LEU ASP ARG LYS VAL GLU ILE PRO LEU          
SEQRES  28 L  437  PRO ASN GLU ALA GLY ARG LEU GLU ILE PHE LYS ILE HIS          
SEQRES  29 L  437  THR ALA LYS VAL LYS LYS THR GLY GLU PHE ASP PHE GLU          
SEQRES  30 L  437  ALA ALA VAL LYS MET SER ASP GLY PHE ASN GLY ALA ASP          
SEQRES  31 L  437  ILE ARG ASN CYS ALA THR GLU ALA GLY PHE PHE ALA ILE          
SEQRES  32 L  437  ARG ASP ASP ARG ASP HIS ILE ASN PRO ASP ASP LEU MET          
SEQRES  33 L  437  LYS ALA VAL ARG LYS VAL ALA GLU VAL LYS LYS LEU GLU          
SEQRES  34 L  437  GLY THR ILE GLU TYR GLN LYS LEU                              
SEQRES   1 M  434  MET ALA THR LEU GLU GLU LEU ASP ALA GLN THR LEU PRO          
SEQRES   2 M  434  GLY ASP ASP GLU LEU ASP GLN GLU ILE LEU ASN LEU SER          
SEQRES   3 M  434  THR GLN GLU LEU GLN THR ARG ALA LYS LEU LEU ASP ASN          
SEQRES   4 M  434  GLU ILE ARG ILE PHE ARG SER GLU LEU GLN ARG LEU SER          
SEQRES   5 M  434  HIS GLU ASN ASN VAL MET LEU GLU LYS ILE LYS ASP ASN          
SEQRES   6 M  434  LYS GLU LYS ILE LYS ASN ASN ARG GLN LEU PRO TYR LEU          
SEQRES   7 M  434  VAL ALA ASN VAL VAL GLU VAL MET ASP MET ASN GLU ILE          
SEQRES   8 M  434  GLU ASP LYS GLU ASN SER GLU SER THR THR GLN GLY GLY          
SEQRES   9 M  434  ASN VAL ASN LEU ASP ASN THR ALA VAL GLY LYS ALA ALA          
SEQRES  10 M  434  VAL VAL LYS THR SER SER ARG GLN THR VAL PHE LEU PRO          
SEQRES  11 M  434  MET VAL GLY LEU VAL ASP PRO ASP LYS LEU LYS PRO ASN          
SEQRES  12 M  434  ASP LEU VAL GLY VAL ASN LYS ASP SER TYR LEU ILE LEU          
SEQRES  13 M  434  ASP THR LEU PRO SER GLU PHE ASP SER ARG VAL LYS ALA          
SEQRES  14 M  434  MET GLU VAL ASP GLU LYS PRO THR GLU THR TYR SER ASP          
SEQRES  15 M  434  VAL GLY GLY LEU ASP LYS GLN ILE GLU GLU LEU VAL GLU          
SEQRES  16 M  434  ALA ILE VAL LEU PRO MET LYS ARG ALA ASP LYS PHE LYS          
SEQRES  17 M  434  ASP MET GLY ILE ARG ALA PRO LYS GLY ALA LEU MET TYR          
SEQRES  18 M  434  GLY PRO PRO GLY THR GLY LYS THR LEU LEU ALA ARG ALA          
SEQRES  19 M  434  CYS ALA ALA GLN THR ASN ALA THR PHE LEU LYS LEU ALA          
SEQRES  20 M  434  ALA PRO GLN LEU VAL GLN MET TYR ILE GLY GLU GLY ALA          
SEQRES  21 M  434  LYS LEU VAL ARG ASP ALA PHE ALA LEU ALA LYS GLU LYS          
SEQRES  22 M  434  ALA PRO THR ILE ILE PHE ILE ASP GLU LEU ASP ALA ILE          
SEQRES  23 M  434  GLY THR LYS ARG PHE ASP SER GLU LYS SER GLY ASP ARG          
SEQRES  24 M  434  GLU VAL GLN ARG THR MET LEU GLU LEU LEU ASN GLN LEU          
SEQRES  25 M  434  ASP GLY PHE SER SER ASP ASP ARG VAL LYS VAL LEU ALA          
SEQRES  26 M  434  ALA THR ASN ARG VAL ASP VAL LEU ASP PRO ALA LEU LEU          
SEQRES  27 M  434  ARG SER GLY ARG LEU ASP ARG LYS ILE GLU PHE PRO LEU          
SEQRES  28 M  434  PRO SER GLU ASP SER ARG ALA GLN ILE LEU GLN ILE HIS          
SEQRES  29 M  434  SER ARG LYS MET THR THR ASP ASP ASP ILE ASN TRP GLN          
SEQRES  30 M  434  GLU LEU ALA ARG SER THR ASP GLU PHE ASN GLY ALA GLN          
SEQRES  31 M  434  LEU LYS ALA VAL THR VAL GLU ALA GLY MET ILE ALA LEU          
SEQRES  32 M  434  ARG ASN GLY GLN SER SER VAL LYS HIS GLU ASP PHE VAL          
SEQRES  33 M  434  GLU GLY ILE SER GLU VAL GLN ALA ARG LYS SER LYS SER          
SEQRES  34 M  434  VAL SER PHE TYR ALA                                          
SEQRES   1 N  945  MET SER LEU THR THR ALA ALA PRO LEU LEU ALA LEU LEU          
SEQRES   2 N  945  ARG GLU ASN GLN ASP SER VAL LYS THR TYR ALA LEU GLU          
SEQRES   3 N  945  SER ILE ASN ASN VAL VAL ASP GLN LEU TRP SER GLU ILE          
SEQRES   4 N  945  SER ASN GLU LEU PRO ASP ILE GLU ALA LEU TYR ASP ASP          
SEQRES   5 N  945  ASP THR PHE SER ASP ARG GLU MET ALA ALA LEU ILE ALA          
SEQRES   6 N  945  SER LYS VAL TYR TYR ASN LEU GLY GLU TYR GLU SER ALA          
SEQRES   7 N  945  VAL LYS TYR ALA LEU ALA ALA LYS ASP ARG PHE ASP ILE          
SEQRES   8 N  945  ASP GLU LYS SER GLN PHE VAL GLU THR ILE VAL SER LYS          
SEQRES   9 N  945  SER ILE GLU MET TYR VAL GLN GLU ALA SER LYS GLN TYR          
SEQRES  10 N  945  THR LYS ASP GLU GLN PHE TYR THR LYS ASP ILE ILE ASP          
SEQRES  11 N  945  PRO LYS LEU THR SER ILE PHE GLU ARG MET ILE GLU LYS          
SEQRES  12 N  945  CYS LEU LYS ALA SER GLU LEU LYS LEU ALA LEU GLY ILE          
SEQRES  13 N  945  ALA LEU GLU GLY TYR ARG LEU ASP ILE ILE GLU SER ALA          
SEQRES  14 N  945  LEU LYS SER LYS LEU ASP GLN ASP SER THR SER GLU ASN          
SEQRES  15 N  945  VAL LYS ILE ILE ASN TYR LEU LEU THR LEU ALA ILE THR          
SEQRES  16 N  945  THR VAL THR ASN SER LYS PHE ARG SER SER ILE LEU ARG          
SEQRES  17 N  945  LYS SER PHE ASP PHE LEU MET ASN MET PRO ASN CYS ASP          
SEQRES  18 N  945  TYR LEU THR LEU ASN LYS VAL VAL VAL ASN LEU ASN ASP          
SEQRES  19 N  945  ALA GLY LEU ALA LEU GLN LEU PHE LYS LYS LEU LYS GLU          
SEQRES  20 N  945  GLU ASN ASP GLU GLY LEU SER ALA GLN ILE ALA PHE ASP          
SEQRES  21 N  945  LEU VAL SER SER ALA SER GLN GLN LEU LEU GLU ILE LEU          
SEQRES  22 N  945  VAL THR GLU LEU THR ALA GLN GLY TYR ASP PRO ALA LEU          
SEQRES  23 N  945  LEU ASN ILE LEU SER GLY LEU PRO THR CYS ASP TYR TYR          
SEQRES  24 N  945  ASN THR PHE LEU LEU ASN ASN LYS ASN ILE ASP ILE GLY          
SEQRES  25 N  945  LEU LEU ASN LYS SER LYS SER SER LEU ASP GLY LYS PHE          
SEQRES  26 N  945  SER LEU PHE HIS THR ALA VAL SER VAL ALA ASN GLY PHE          
SEQRES  27 N  945  MET HIS ALA GLY THR THR ASP ASN SER PHE ILE LYS ALA          
SEQRES  28 N  945  ASN LEU PRO TRP LEU GLY LYS ALA GLN ASN TRP ALA LYS          
SEQRES  29 N  945  PHE THR ALA THR ALA SER LEU GLY VAL ILE HIS LYS GLY          
SEQRES  30 N  945  ASN LEU LEU GLU GLY LYS LYS VAL MET ALA PRO TYR LEU          
SEQRES  31 N  945  PRO GLY SER ARG ALA SER SER ARG PHE ILE LYS GLY GLY          
SEQRES  32 N  945  SER LEU TYR GLY LEU GLY LEU ILE TYR ALA GLY PHE GLY          
SEQRES  33 N  945  ARG ASP THR THR ASP TYR LEU LYS ASN ILE ILE VAL GLU          
SEQRES  34 N  945  ASN SER GLY THR SER GLY ASP GLU ASP VAL ASP VAL LEU          
SEQRES  35 N  945  LEU HIS GLY ALA SER LEU GLY ILE GLY LEU ALA ALA MET          
SEQRES  36 N  945  GLY SER ALA ASN ILE GLU VAL TYR GLU ALA LEU LYS GLU          
SEQRES  37 N  945  VAL LEU TYR ASN ASP SER ALA THR SER GLY GLU ALA ALA          
SEQRES  38 N  945  ALA LEU GLY MET GLY LEU CYS MET LEU GLY THR GLY LYS          
SEQRES  39 N  945  PRO GLU ALA ILE HIS ASP MET PHE THR TYR SER GLN GLU          
SEQRES  40 N  945  THR GLN HIS GLY ASN ILE THR ARG GLY LEU ALA VAL GLY          
SEQRES  41 N  945  LEU ALA LEU ILE ASN TYR GLY ARG GLN GLU LEU ALA ASP          
SEQRES  42 N  945  ASP LEU ILE THR LYS MET LEU ALA SER ASP GLU SER LEU          
SEQRES  43 N  945  LEU ARG TYR GLY GLY ALA PHE THR ILE ALA LEU ALA TYR          
SEQRES  44 N  945  ALA GLY THR GLY ASN ASN SER ALA VAL LYS ARG LEU LEU          
SEQRES  45 N  945  HIS VAL ALA VAL SER ASP SER ASN ASP ASP VAL ARG ARG          
SEQRES  46 N  945  ALA ALA VAL ILE ALA LEU GLY PHE VAL LEU LEU ARG ASP          
SEQRES  47 N  945  TYR THR THR VAL PRO ARG ILE VAL GLN LEU LEU SER LYS          
SEQRES  48 N  945  SER HIS ASN ALA HIS VAL ARG CYS GLY THR ALA PHE ALA          
SEQRES  49 N  945  LEU GLY ILE ALA CYS ALA GLY LYS GLY LEU GLN SER ALA          
SEQRES  50 N  945  ILE ASP VAL LEU ASP PRO LEU THR LYS ASP PRO VAL ASP          
SEQRES  51 N  945  PHE VAL ARG GLN ALA ALA MET ILE ALA LEU SER MET ILE          
SEQRES  52 N  945  LEU ILE GLN GLN THR GLU LYS LEU ASN PRO GLN VAL ALA          
SEQRES  53 N  945  ASP ILE ASN LYS ASN PHE LEU SER VAL ILE THR ASN LYS          
SEQRES  54 N  945  HIS GLN GLU GLY LEU ALA LYS PHE GLY ALA CYS VAL ALA          
SEQRES  55 N  945  GLN GLY ILE MET ASN ALA GLY GLY ARG ASN VAL THR ILE          
SEQRES  56 N  945  GLN LEU GLU ASN ALA ASP THR GLY THR LEU ASP THR LYS          
SEQRES  57 N  945  SER VAL VAL GLY LEU VAL MET PHE SER GLN PHE TRP TYR          
SEQRES  58 N  945  TRP PHE PRO LEU ALA HIS PHE LEU SER LEU SER PHE THR          
SEQRES  59 N  945  PRO THR THR VAL ILE GLY ILE ARG GLY SER ASP GLN ALA          
SEQRES  60 N  945  ILE PRO LYS PHE GLN MET ASN CYS TYR ALA LYS GLU ASP          
SEQRES  61 N  945  ALA PHE SER TYR PRO ARG MET TYR GLU GLU ALA SER GLY          
SEQRES  62 N  945  LYS GLU VAL GLU LYS VAL ALA THR ALA VAL LEU SER THR          
SEQRES  63 N  945  THR ALA ARG ALA LYS ALA ARG ALA LYS LYS THR LYS LYS          
SEQRES  64 N  945  GLU LYS GLY PRO ASN GLU GLU GLU LYS LYS LYS GLU HIS          
SEQRES  65 N  945  GLU GLU LYS GLU LYS GLU ARG GLU THR ASN LYS LYS GLY          
SEQRES  66 N  945  ILE LYS GLU THR LYS GLU ASN ASP GLU GLU PHE TYR LYS          
SEQRES  67 N  945  ASN LYS TYR SER SER LYS PRO TYR LYS VAL ASP ASN MET          
SEQRES  68 N  945  THR ARG ILE LEU PRO GLN GLN SER ARG TYR ILE SER PHE          
SEQRES  69 N  945  ILE LYS ASP ASP ARG PHE VAL PRO VAL ARG LYS PHE LYS          
SEQRES  70 N  945  GLY ASN ASN GLY VAL VAL VAL LEU ARG ASP ARG GLU PRO          
SEQRES  71 N  945  LYS GLU PRO VAL ALA LEU ILE GLU THR VAL ARG GLN MET          
SEQRES  72 N  945  LYS ASP VAL ASN ALA PRO LEU PRO THR PRO PHE LYS VAL          
SEQRES  73 N  945  ASP ASP ASN VAL ASP PHE PRO SER ALA                          
SEQRES   1 O  393  MET PHE ASN ASN HIS GLU ILE ASP THR ILE LEU SER THR          
SEQRES   2 O  393  LEU ARG MET GLU ALA ASP PRO SER LEU HIS PRO LEU PHE          
SEQRES   3 O  393  GLU GLN PHE GLU LYS PHE TYR GLU GLU LYS LEU TRP PHE          
SEQRES   4 O  393  GLN LEU SER GLU SER LEU THR LYS PHE PHE ASP ASP ALA          
SEQRES   5 O  393  LYS SER THR PRO LEU ARG LEU ARG LEU TYR ASP ASN PHE          
SEQRES   6 O  393  VAL SER LYS PHE TYR ASP LYS ILE ASN GLN LEU SER VAL          
SEQRES   7 O  393  VAL LYS TYR LEU LEU ALA SER LEU LYS ASP SER LYS ASP          
SEQRES   8 O  393  PHE ASP GLU SER LEU LYS TYR LEU ASP ASP LEU LYS ALA          
SEQRES   9 O  393  GLN PHE GLN GLU LEU ASP SER LYS LYS GLN ARG ASN ASN          
SEQRES  10 O  393  GLY SER LYS ASP HIS GLY ASP GLY ILE LEU LEU ILE ASP          
SEQRES  11 O  393  SER GLU ILE ALA ARG THR TYR LEU LEU LYS ASN ASP LEU          
SEQRES  12 O  393  VAL LYS ALA ARG ASP LEU LEU ASP ASP LEU GLU LYS THR          
SEQRES  13 O  393  LEU ASP LYS LYS ASP SER ILE PRO LEU ARG ILE THR ASN          
SEQRES  14 O  393  SER PHE TYR SER THR ASN SER GLN TYR PHE LYS PHE LYS          
SEQRES  15 O  393  ASN ASP PHE ASN SER PHE TYR TYR THR SER LEU LEU TYR          
SEQRES  16 O  393  LEU SER THR LEU GLU PRO SER THR SER ILE THR LEU ALA          
SEQRES  17 O  393  GLU ARG GLN GLN LEU ALA TYR ASP LEU SER ILE SER ALA          
SEQRES  18 O  393  LEU LEU GLY ASP LYS ILE TYR ASN PHE GLY GLU LEU LEU          
SEQRES  19 O  393  HIS HIS PRO ILE MET GLU THR ILE VAL ASN ASP SER ASN          
SEQRES  20 O  393  TYR ASP TRP LEU PHE GLN LEU LEU ASN ALA LEU THR VAL          
SEQRES  21 O  393  GLY ASP PHE ASP LYS PHE ASP SER LEU ILE LYS VAL GLN          
SEQRES  22 O  393  ILE SER LYS ILE PRO ILE LEU ALA GLN HIS GLU SER PHE          
SEQRES  23 O  393  LEU ARG GLN LYS ILE CYS LEU MET THR LEU ILE GLU THR          
SEQRES  24 O  393  VAL PHE VAL LYS ASN ILE ARG MET LEU SER PHE GLU ASP          
SEQRES  25 O  393  ILE SER LYS ALA THR HIS LEU PRO LYS ASP ASN VAL GLU          
SEQRES  26 O  393  HIS LEU VAL MET ARG ALA ILE SER LEU GLY LEU LEU LYS          
SEQRES  27 O  393  GLY SER ILE ASP GLN VAL ASN GLU LEU VAL THR ILE SER          
SEQRES  28 O  393  TRP VAL GLN PRO ARG ILE ILE SER GLY ASP GLN ILE THR          
SEQRES  29 O  393  LYS MET LYS ASP ARG LEU VAL GLU TRP ASN ASP GLN VAL          
SEQRES  30 O  393  GLU LYS LEU GLY LYS LYS MET GLU ALA ARG GLY GLN SER          
SEQRES  31 O  393  ILE TRP VAL                                                  
SEQRES   1 P  445  MET SER ARG ASP ALA PRO ILE LYS ALA ASP LYS ASP TYR          
SEQRES   2 P  445  SER GLN ILE LEU LYS GLU GLU PHE PRO LYS ILE ASP SER          
SEQRES   3 P  445  LEU ALA GLN ASN ASP CYS ASN SER ALA LEU ASP GLN LEU          
SEQRES   4 P  445  LEU VAL LEU GLU LYS LYS THR ARG GLN ALA SER ASP LEU          
SEQRES   5 P  445  ALA SER SER LYS GLU VAL LEU ALA LYS ILE VAL ASP LEU          
SEQRES   6 P  445  LEU ALA SER ARG ASN LYS TRP ASP ASP LEU ASN GLU GLN          
SEQRES   7 P  445  LEU THR LEU LEU SER LYS LYS HIS GLY GLN LEU LYS LEU          
SEQRES   8 P  445  SER ILE GLN TYR MET ILE GLN LYS VAL MET GLU TYR LEU          
SEQRES   9 P  445  LYS SER SER LYS SER LEU ASP LEU ASN THR ARG ILE SER          
SEQRES  10 P  445  VAL ILE GLU THR ILE ARG VAL VAL THR GLU ASN LYS ILE          
SEQRES  11 P  445  PHE VAL GLU VAL GLU ARG ALA ARG VAL THR LYS ASP LEU          
SEQRES  12 P  445  VAL GLU ILE LYS LYS GLU GLU GLY LYS ILE ASP GLU ALA          
SEQRES  13 P  445  ALA ASP ILE LEU CYS GLU LEU GLN VAL GLU THR TYR GLY          
SEQRES  14 P  445  SER MET GLU MET SER GLU LYS ILE GLN PHE ILE LEU GLU          
SEQRES  15 P  445  GLN MET GLU LEU SER ILE LEU LYS GLY ASP TYR SER GLN          
SEQRES  16 P  445  ALA THR VAL LEU SER ARG LYS ILE LEU LYS LYS THR PHE          
SEQRES  17 P  445  LYS ASN PRO LYS TYR GLU SER LEU LYS LEU GLU TYR TYR          
SEQRES  18 P  445  ASN LEU LEU VAL LYS ILE SER LEU HIS LYS ARG GLU TYR          
SEQRES  19 P  445  LEU GLU VAL ALA GLN TYR LEU GLN GLU ILE TYR GLN THR          
SEQRES  20 P  445  ASP ALA ILE LYS SER ASP GLU ALA LYS TRP LYS PRO VAL          
SEQRES  21 P  445  LEU SER HIS ILE VAL TYR PHE LEU VAL LEU SER PRO TYR          
SEQRES  22 P  445  GLY ASN LEU GLN ASN ASP LEU ILE HIS LYS ILE GLN ASN          
SEQRES  23 P  445  ASP ASN ASN LEU LYS LYS LEU GLU SER GLN GLU SER LEU          
SEQRES  24 P  445  VAL LYS LEU PHE THR THR ASN GLU LEU MET ARG TRP PRO          
SEQRES  25 P  445  ILE VAL GLN LYS THR TYR GLU PRO VAL LEU ASN GLU ASP          
SEQRES  26 P  445  ASP LEU ALA PHE GLY GLY GLU ALA ASN LYS HIS HIS TRP          
SEQRES  27 P  445  GLU ASP LEU GLN LYS ARG VAL ILE GLU HIS ASN LEU ARG          
SEQRES  28 P  445  VAL ILE SER GLU TYR TYR SER ARG ILE THR LEU LEU ARG          
SEQRES  29 P  445  LEU ASN GLU LEU LEU ASP LEU THR GLU SER GLN THR GLU          
SEQRES  30 P  445  THR TYR ILE SER ASP LEU VAL ASN GLN GLY ILE ILE TYR          
SEQRES  31 P  445  ALA LYS VAL ASN ARG PRO ALA LYS ILE VAL ASN PHE GLU          
SEQRES  32 P  445  LYS PRO LYS ASN SER SER GLN LEU LEU ASN GLU TRP SER          
SEQRES  33 P  445  HIS ASN VAL ASP GLU LEU LEU GLU HIS ILE GLU THR ILE          
SEQRES  34 P  445  GLY HIS LEU ILE THR LYS GLU GLU ILE MET HIS GLY LEU          
SEQRES  35 P  445  GLN ALA LYS                                                  
SEQRES   1 Q  434  MET SER LEU PRO GLY SER LYS LEU GLU GLU ALA ARG ARG          
SEQRES   2 Q  434  LEU VAL ASN GLU LYS GLN TYR ASN GLU ALA GLU GLN VAL          
SEQRES   3 Q  434  TYR LEU SER LEU LEU ASP LYS ASP SER SER GLN SER SER          
SEQRES   4 Q  434  ALA ALA ALA GLY ALA SER VAL ASP ASP LYS ARG ARG ASN          
SEQRES   5 Q  434  GLU GLN GLU THR SER ILE LEU GLU LEU GLY GLN LEU TYR          
SEQRES   6 Q  434  VAL THR MET GLY ALA LYS ASP LYS LEU ARG GLU PHE ILE          
SEQRES   7 Q  434  PRO HIS SER THR GLU TYR MET MET GLN PHE ALA LYS SER          
SEQRES   8 Q  434  LYS THR VAL LYS VAL LEU LYS THR LEU ILE GLU LYS PHE          
SEQRES   9 Q  434  GLU GLN VAL PRO ASP SER LEU ASP ASP GLN ILE PHE VAL          
SEQRES  10 Q  434  CYS GLU LYS SER ILE GLU PHE ALA LYS ARG GLU LYS ARG          
SEQRES  11 Q  434  VAL PHE LEU LYS HIS SER LEU SER ILE LYS LEU ALA THR          
SEQRES  12 Q  434  LEU HIS TYR GLN LYS LYS GLN TYR LYS ASP SER LEU ALA          
SEQRES  13 Q  434  LEU ILE ASN ASP LEU LEU ARG GLU PHE LYS LYS LEU ASP          
SEQRES  14 Q  434  ASP LYS PRO SER LEU VAL ASP VAL HIS LEU LEU GLU SER          
SEQRES  15 Q  434  LYS VAL TYR HIS LYS LEU ARG ASN LEU ALA LYS SER LYS          
SEQRES  16 Q  434  ALA SER LEU THR ALA ALA ARG THR ALA ALA ASN SER ILE          
SEQRES  17 Q  434  TYR CYS PRO THR GLN THR VAL ALA GLU LEU ASP LEU MET          
SEQRES  18 Q  434  SER GLY ILE LEU HIS CYS GLU ASP LYS ASP TYR LYS THR          
SEQRES  19 Q  434  ALA PHE SER TYR PHE PHE GLU SER PHE GLU SER TYR HIS          
SEQRES  20 Q  434  ASN LEU THR THR HIS ASN SER TYR GLU LYS ALA CYS GLN          
SEQRES  21 Q  434  VAL LEU LYS TYR MET LEU LEU SER LYS ILE MET LEU ASN          
SEQRES  22 Q  434  LEU ILE ASP ASP VAL LYS ASN ILE LEU ASN ALA LYS TYR          
SEQRES  23 Q  434  THR LYS GLU THR TYR GLN SER ARG GLY ILE ASP ALA MET          
SEQRES  24 Q  434  LYS ALA VAL ALA GLU ALA TYR ASN ASN ARG SER LEU LEU          
SEQRES  25 Q  434  ASP PHE ASN THR ALA LEU LYS GLN TYR GLU LYS GLU LEU          
SEQRES  26 Q  434  MET GLY ASP GLU LEU THR ARG SER HIS PHE ASN ALA LEU          
SEQRES  27 Q  434  TYR ASP THR LEU LEU GLU SER ASN LEU CYS LYS ILE ILE          
SEQRES  28 Q  434  GLU PRO PHE GLU CYS VAL GLU ILE SER HIS ILE SER LYS          
SEQRES  29 Q  434  ILE ILE GLY LEU ASP THR GLN GLN VAL GLU GLY LYS LEU          
SEQRES  30 Q  434  SER GLN MET ILE LEU ASP LYS ILE PHE TYR GLY VAL LEU          
SEQRES  31 Q  434  ASP GLN GLY ASN GLY TRP LEU TYR VAL TYR GLU THR PRO          
SEQRES  32 Q  434  ASN GLN ASP ALA THR TYR ASP SER ALA LEU GLU LEU VAL          
SEQRES  33 Q  434  GLY GLN LEU ASN LYS VAL VAL ASP GLN LEU PHE GLU LYS          
SEQRES  34 Q  434  ALA SER VAL LEU TYR                                          
SEQRES   1 R  429  MET VAL ASP VAL GLU GLU LYS SER GLN GLU VAL GLU TYR          
SEQRES   2 R  429  VAL ASP PRO THR VAL ASN ARG VAL PRO ASN TYR GLU VAL          
SEQRES   3 R  429  SER GLU LYS ALA PHE LEU LEU THR GLN SER LYS VAL SER          
SEQRES   4 R  429  ILE GLU GLN ARG LYS GLU ALA ALA GLU PHE VAL LEU ALA          
SEQRES   5 R  429  LYS ILE LYS GLU GLU GLU MET ALA PRO TYR TYR LYS TYR          
SEQRES   6 R  429  LEU CYS GLU GLU TYR LEU VAL ASN ASN GLY GLN SER ASP          
SEQRES   7 R  429  LEU GLU HIS ASP GLU LYS SER ASP SER LEU ASN GLU TRP          
SEQRES   8 R  429  ILE LYS PHE ASP GLN GLU LEU TYR ASN GLU LEU CYS LYS          
SEQRES   9 R  429  LYS ASN GLU SER LYS ILE LYS GLU LEU ASN GLU LYS ILE          
SEQRES  10 R  429  GLN LYS LEU GLU GLU ASP ASP GLU GLY GLU LEU GLU GLN          
SEQRES  11 R  429  ALA GLN ALA TRP ILE ASN LEU GLY GLU TYR TYR ALA GLN          
SEQRES  12 R  429  ILE GLY ASP LYS ASP ASN ALA GLU LYS THR LEU GLY LYS          
SEQRES  13 R  429  SER LEU SER LYS ALA ILE SER THR GLY ALA LYS ILE ASP          
SEQRES  14 R  429  VAL MET LEU THR ILE ALA ARG LEU GLY PHE PHE TYR ASN          
SEQRES  15 R  429  ASP GLN LEU TYR VAL LYS GLU LYS LEU GLU ALA VAL ASN          
SEQRES  16 R  429  SER MET ILE GLU LYS GLY GLY ASP TRP GLU ARG ARG ASN          
SEQRES  17 R  429  ARG TYR LYS THR TYR TYR GLY ILE HIS CYS LEU ALA VAL          
SEQRES  18 R  429  ARG ASN PHE LYS GLU ALA ALA LYS LEU LEU VAL ASP SER          
SEQRES  19 R  429  LEU ALA THR PHE THR SER ILE GLU LEU THR SER TYR GLU          
SEQRES  20 R  429  SER ILE ALA THR TYR ALA SER VAL THR GLY LEU PHE THR          
SEQRES  21 R  429  LEU GLU ARG THR ASP LEU LYS SER LYS VAL ILE ASP SER          
SEQRES  22 R  429  PRO GLU LEU LEU SER LEU ILE SER THR THR ALA ALA LEU          
SEQRES  23 R  429  GLN SER ILE SER SER LEU THR ILE SER LEU TYR ALA SER          
SEQRES  24 R  429  ASP TYR ALA SER TYR PHE PRO TYR LEU LEU GLU THR TYR          
SEQRES  25 R  429  ALA ASN VAL LEU ILE PRO CYS LYS TYR LEU ASN ARG HIS          
SEQRES  26 R  429  ALA ASP PHE PHE VAL ARG GLU MET ARG ARG LYS VAL TYR          
SEQRES  27 R  429  ALA GLN LEU LEU GLU SER TYR LYS THR LEU SER LEU LYS          
SEQRES  28 R  429  SER MET ALA SER ALA PHE GLY VAL SER VAL ALA PHE LEU          
SEQRES  29 R  429  ASP ASN ASP LEU GLY LYS PHE ILE PRO ASN LYS GLN LEU          
SEQRES  30 R  429  ASN CYS VAL ILE ASP ARG VAL ASN GLY ILE VAL GLU THR          
SEQRES  31 R  429  ASN ARG PRO ASP ASN LYS ASN ALA GLN TYR HIS LEU LEU          
SEQRES  32 R  429  VAL LYS GLN GLY ASP GLY LEU LEU THR LYS LEU GLN LYS          
SEQRES  33 R  429  TYR GLY ALA ALA VAL ARG LEU THR GLY SER ASP ARG VAL          
SEQRES   1 S  523  MET ALA SER THR ALA VAL MET MET ASP VAL ASP SER SER          
SEQRES   2 S  523  GLY VAL ASN ASP LEU HIS HIS SER GLU LYS LYS TYR ALA          
SEQRES   3 S  523  GLU GLU ASP GLN VAL GLN GLU LEU LEU LYS VAL LEU ASN          
SEQRES   4 S  523  GLU ILE SER LYS THR THR LEU THR LEU ASP PRO ARG TYR          
SEQRES   5 S  523  ILE TRP ARG SER LEU LYS ASP LEU SER SER LEU ARG ASN          
SEQRES   6 S  523  GLN GLU LEU LEU ASN ALA GLU THR LEU CYS PHE THR VAL          
SEQRES   7 S  523  ASN VAL LEU TYR PRO ASP SER SER SER PHE LYS LYS ASN          
SEQRES   8 S  523  LEU LEU LYS PHE ILE THR SER ASN HIS LYS SER SER VAL          
SEQRES   9 S  523  PRO GLY SER ALA GLU LEU ARG ASN SER TYR PRO ALA SER          
SEQRES  10 S  523  PHE TYR SER VAL ASN THR GLU LYS LYS THR ILE GLU VAL          
SEQRES  11 S  523  THR ALA GLU ILE ASN CYS PHE MET HIS LEU LEU VAL GLN          
SEQRES  12 S  523  LEU PHE LEU TRP ASP SER LYS GLU LEU GLU GLN LEU VAL          
SEQRES  13 S  523  GLU PHE ASN ARG LYS VAL VAL ILE PRO ASN LEU LEU CYS          
SEQRES  14 S  523  TYR TYR ASN LEU ARG SER LEU ASN LEU ILE ASN ALA LYS          
SEQRES  15 S  523  LEU TRP PHE TYR ILE TYR LEU SER HIS GLU THR LEU ALA          
SEQRES  16 S  523  ARG SER SER GLU GLU ILE ASN SER ASP ASN GLN ASN ILE          
SEQRES  17 S  523  ILE LEU ARG SER THR MET MET LYS PHE LEU LYS ILE ALA          
SEQRES  18 S  523  SER LEU LYS HIS ASP ASN GLU THR LYS ALA MET LEU ILE          
SEQRES  19 S  523  ASN LEU ILE LEU ARG ASP PHE LEU ASN ASN GLY GLU VAL          
SEQRES  20 S  523  ASP SER ALA SER ASP PHE ILE SER LYS LEU GLU TYR PRO          
SEQRES  21 S  523  HIS THR ASP VAL SER SER SER LEU GLU ALA ARG TYR PHE          
SEQRES  22 S  523  PHE TYR LEU SER LYS ILE ASN ALA ILE GLN LEU ASP TYR          
SEQRES  23 S  523  SER THR ALA ASN GLU TYR ILE ILE ALA ALA ILE ARG LYS          
SEQRES  24 S  523  ALA PRO HIS ASN SER LYS SER LEU GLY PHE LEU GLN GLN          
SEQRES  25 S  523  SER ASN LYS LEU HIS CYS CYS ILE GLN LEU LEU MET GLY          
SEQRES  26 S  523  ASP ILE PRO GLU LEU SER PHE PHE HIS GLN SER ASN MET          
SEQRES  27 S  523  GLN LYS SER LEU LEU PRO TYR TYR HIS LEU THR LYS ALA          
SEQRES  28 S  523  VAL LYS LEU GLY ASP LEU LYS LYS PHE THR SER THR ILE          
SEQRES  29 S  523  THR LYS TYR LYS GLN LEU LEU LEU LYS ASP ASP THR TYR          
SEQRES  30 S  523  GLN LEU CYS VAL ARG LEU ARG SER ASN VAL ILE LYS THR          
SEQRES  31 S  523  GLY ILE ARG ILE ILE SER LEU THR TYR LYS LYS ILE SER          
SEQRES  32 S  523  LEU ARG ASP ILE CYS LEU LYS LEU ASN LEU ASP SER GLU          
SEQRES  33 S  523  GLN THR VAL GLU TYR MET VAL SER ARG ALA ILE ARG ASP          
SEQRES  34 S  523  GLY VAL ILE GLU ALA LYS ILE ASN HIS GLU ASP GLY PHE          
SEQRES  35 S  523  ILE GLU THR THR GLU LEU LEU ASN ILE TYR ASP SER GLU          
SEQRES  36 S  523  ASP PRO GLN GLN VAL PHE ASP GLU ARG ILE LYS PHE ALA          
SEQRES  37 S  523  ASN GLN LEU HIS ASP GLU TYR LEU VAL SER MET ARG TYR          
SEQRES  38 S  523  PRO GLU ASP LYS LYS THR GLN GLN ASN GLU LYS SER GLU          
SEQRES  39 S  523  ASN GLY GLU ASN ASP ASP ASP THR LEU ASP GLY ASP LEU          
SEQRES  40 S  523  MET ASP ASP MET SER ASP ILE SER ASP LEU ASP ASP LEU          
SEQRES  41 S  523  GLY PHE LEU                                                  
SEQRES   1 T  274  MET PRO SER LEU ALA GLU LEU THR LYS SER LEU SER ILE          
SEQRES   2 T  274  ALA PHE GLU ASN GLY ASP TYR ALA ALA CYS GLU LYS LEU          
SEQRES   3 T  274  LEU PRO PRO ILE LYS ILE GLU LEU ILE LYS ASN ASN LEU          
SEQRES   4 T  274  LEU ILE PRO ASP LEU SER ILE GLN ASN ASP ILE TYR LEU          
SEQRES   5 T  274  ASN ASP LEU MET ILE THR LYS ARG ILE LEU GLU VAL GLY          
SEQRES   6 T  274  ALA LEU ALA SER ILE GLN THR PHE ASN PHE ASP SER PHE          
SEQRES   7 T  274  GLU ASN TYR PHE ASN GLN LEU LYS PRO TYR TYR PHE SER          
SEQRES   8 T  274  ASN ASN HIS LYS LEU SER GLU SER ASP LYS LYS SER LYS          
SEQRES   9 T  274  LEU ILE SER LEU TYR LEU LEU ASN LEU LEU SER GLN ASN          
SEQRES  10 T  274  ASN THR THR LYS PHE HIS SER GLU LEU GLN TYR LEU ASP          
SEQRES  11 T  274  LYS HIS ILE LYS ASN LEU GLU ASP ASP SER LEU LEU SER          
SEQRES  12 T  274  TYR PRO ILE LYS LEU ASP ARG TRP LEU MET GLU GLY SER          
SEQRES  13 T  274  TYR GLN LYS ALA TRP ASP LEU LEU GLN SER GLY SER GLN          
SEQRES  14 T  274  ASN ILE SER GLU PHE ASP SER PHE THR ASP ILE LEU LYS          
SEQRES  15 T  274  SER ALA ILE ARG ASP GLU ILE ALA LYS ASN THR GLU LEU          
SEQRES  16 T  274  SER TYR ASP PHE LEU PRO LEU SER ASN ILE LYS ALA LEU          
SEQRES  17 T  274  LEU PHE PHE ASN ASN GLU LYS GLU THR GLU LYS PHE ALA          
SEQRES  18 T  274  LEU GLU ARG ASN TRP PRO ILE VAL ASN SER LYS VAL TYR          
SEQRES  19 T  274  PHE ASN ASN GLN SER LYS GLU LYS ALA ASP TYR GLU ASP          
SEQRES  20 T  274  GLU MET MET HIS GLU GLU ASP GLN LYS THR ASN ILE ILE          
SEQRES  21 T  274  GLU LYS ALA MET ASP TYR ALA ILE SER ILE GLU ASN ILE          
SEQRES  22 T  274  VAL                                                          
SEQRES   1 U  338  MET SER LEU GLN HIS GLU LYS VAL THR ILE ALA PRO LEU          
SEQRES   2 U  338  VAL LEU LEU SER ALA LEU ASP HIS TYR GLU ARG THR GLN          
SEQRES   3 U  338  THR LYS GLU ASN LYS ARG CYS VAL GLY VAL ILE LEU GLY          
SEQRES   4 U  338  ASP ALA ASN SER SER THR ILE ARG VAL THR ASN SER PHE          
SEQRES   5 U  338  ALA LEU PRO PHE GLU GLU ASP GLU LYS ASN SER ASP VAL          
SEQRES   6 U  338  TRP PHE LEU ASP HIS ASN TYR ILE GLU ASN MET ASN GLU          
SEQRES   7 U  338  MET CYS LYS LYS ILE ASN ALA LYS GLU LYS LEU ILE GLY          
SEQRES   8 U  338  TRP TYR HIS SER GLY PRO LYS LEU ARG ALA SER ASP LEU          
SEQRES   9 U  338  LYS ILE ASN GLU LEU PHE LYS LYS TYR THR GLN ASN ASN          
SEQRES  10 U  338  PRO LEU LEU LEU ILE VAL ASP VAL LYS GLN GLN GLY VAL          
SEQRES  11 U  338  GLY LEU PRO THR ASP ALA TYR VAL ALA ILE GLU GLN VAL          
SEQRES  12 U  338  LYS ASP ASP GLY THR SER THR GLU LYS THR PHE LEU HIS          
SEQRES  13 U  338  LEU PRO CYS THR ILE GLU ALA GLU GLU ALA GLU GLU ILE          
SEQRES  14 U  338  GLY VAL GLU HIS LEU LEU ARG ASP VAL ARG ASP GLN ALA          
SEQRES  15 U  338  ALA GLY GLY LEU SER ILE ARG LEU THR ASN GLN LEU LYS          
SEQRES  16 U  338  SER LEU LYS GLY LEU GLN SER LYS LEU LYS ASP VAL VAL          
SEQRES  17 U  338  GLU TYR LEU ASP LYS VAL ILE ASN LYS GLU LEU PRO ILE          
SEQRES  18 U  338  ASN HIS THR ILE LEU GLY LYS LEU GLN ASP VAL PHE ASN          
SEQRES  19 U  338  LEU LEU PRO ASN LEU GLY THR PRO ASP ASP ASP GLU ILE          
SEQRES  20 U  338  ASP VAL GLU ASN HIS ASP ARG ILE ASN ILE SER ASN ASN          
SEQRES  21 U  338  LEU GLN LYS ALA LEU THR VAL LYS THR ASN ASP GLU LEU          
SEQRES  22 U  338  MET VAL ILE TYR ILE SER ASN LEU VAL ARG SER ILE ILE          
SEQRES  23 U  338  ALA PHE ASP ASP LEU ILE GLU ASN LYS ILE GLN ASN LYS          
SEQRES  24 U  338  LYS ILE GLN GLU GLN ARG VAL LYS ASP LYS GLN SER LYS          
SEQRES  25 U  338  VAL SER ASP ASP SER GLU SER GLU SER GLY ASP LYS GLU          
SEQRES  26 U  338  ALA THR ALA PRO LEU ILE GLN ARG LYS ASN LYS LYS ASN          
SEQRES   1 V  306  MET GLU ARG LEU GLN ARG LEU MET MET ASN SER LYS VAL          
SEQRES   2 V  306  GLY SER ALA ASP THR GLY ARG ASP ASP THR LYS GLU THR          
SEQRES   3 V  306  VAL TYR ILE SER SER ILE ALA LEU LEU LYS MET LEU LYS          
SEQRES   4 V  306  HIS GLY ARG ALA GLY VAL PRO MET GLU VAL MET GLY LEU          
SEQRES   5 V  306  MET LEU GLY GLU PHE VAL ASP ASP TYR THR VAL ASN VAL          
SEQRES   6 V  306  VAL ASP VAL PHE ALA MET PRO GLN SER GLY THR GLY VAL          
SEQRES   7 V  306  SER VAL GLU ALA VAL ASP ASP VAL PHE GLN ALA LYS MET          
SEQRES   8 V  306  MET ASP MET LEU LYS GLN THR GLY ARG ASP GLN MET VAL          
SEQRES   9 V  306  VAL GLY TRP TYR HIS SER HIS PRO GLY PHE GLY CYS TRP          
SEQRES  10 V  306  LEU SER SER VAL ASP VAL ASN THR GLN LYS SER PHE GLU          
SEQRES  11 V  306  GLN LEU ASN SER ARG ALA VAL ALA VAL VAL VAL ASP PRO          
SEQRES  12 V  306  ILE GLN SER VAL LYS GLY LYS VAL VAL ILE ASP ALA PHE          
SEQRES  13 V  306  ARG LEU ILE ASP THR GLY ALA LEU ILE ASN ASN LEU GLU          
SEQRES  14 V  306  PRO ARG GLN THR THR SER ASN THR GLY LEU LEU ASN LYS          
SEQRES  15 V  306  ALA ASN ILE GLN ALA LEU ILE HIS GLY LEU ASN ARG HIS          
SEQRES  16 V  306  TYR TYR SER LEU ASN ILE ASP TYR HIS LYS THR ALA LYS          
SEQRES  17 V  306  GLU THR LYS MET LEU MET ASN LEU HIS LYS GLU GLN TRP          
SEQRES  18 V  306  GLN SER GLY LEU LYS MET TYR ASP TYR GLU GLU LYS GLU          
SEQRES  19 V  306  GLU SER ASN LEU ALA ALA THR LYS SER MET VAL LYS ILE          
SEQRES  20 V  306  ALA GLU GLN TYR SER LYS ARG ILE GLU GLU GLU LYS GLU          
SEQRES  21 V  306  LEU THR GLU GLU GLU LEU LYS THR ARG TYR VAL GLY ARG          
SEQRES  22 V  306  GLN ASP PRO LYS LYS HIS LEU SER GLU THR ALA ASP GLU          
SEQRES  23 V  306  THR LEU GLU ASN ASN ILE VAL SER VAL LEU THR ALA GLY          
SEQRES  24 V  306  VAL ASN SER VAL ALA ILE LYS                                  
SEQRES   1 W  268  MET VAL LEU GLU ALA THR VAL LEU VAL ILE ASP ASN SER          
SEQRES   2 W  268  GLU TYR SER ARG ASN GLY ASP PHE PRO ARG THR ARG PHE          
SEQRES   3 W  268  GLU ALA GLN ILE ASP SER VAL GLU PHE ILE PHE GLN ALA          
SEQRES   4 W  268  LYS ARG ASN SER ASN PRO GLU ASN THR VAL GLY LEU ILE          
SEQRES   5 W  268  SER GLY ALA GLY ALA ASN PRO ARG VAL LEU SER THR PHE          
SEQRES   6 W  268  THR ALA GLU PHE GLY LYS ILE LEU ALA GLY LEU HIS ASP          
SEQRES   7 W  268  THR GLN ILE GLU GLY LYS LEU HIS MET ALA THR ALA LEU          
SEQRES   8 W  268  GLN ILE ALA GLN LEU THR LEU LYS HIS ARG GLN ASN LYS          
SEQRES   9 W  268  VAL GLN HIS GLN ARG ILE VAL ALA PHE VAL CYS SER PRO          
SEQRES  10 W  268  ILE SER ASP SER ARG ASP GLU LEU ILE ARG LEU ALA LYS          
SEQRES  11 W  268  THR LEU LYS LYS ASN ASN VAL ALA VAL ASP ILE ILE ASN          
SEQRES  12 W  268  PHE GLY GLU ILE GLU GLN ASN THR GLU LEU LEU ASP GLU          
SEQRES  13 W  268  PHE ILE ALA ALA VAL ASN ASN PRO GLN GLU GLU THR SER          
SEQRES  14 W  268  HIS LEU LEU THR VAL THR PRO GLY PRO ARG LEU LEU TYR          
SEQRES  15 W  268  GLU ASN ILE ALA SER SER PRO ILE ILE LEU GLU GLU GLY          
SEQRES  16 W  268  SER SER GLY MET GLY ALA PHE GLY GLY SER GLY GLY ASP          
SEQRES  17 W  268  SER ASP ALA ASN GLY THR PHE MET ASP PHE GLY VAL ASP          
SEQRES  18 W  268  PRO SER MET ASP PRO GLU LEU ALA MET ALA LEU ARG LEU          
SEQRES  19 W  268  SER MET GLU GLU GLU GLN GLN ARG GLN GLU ARG LEU ARG          
SEQRES  20 W  268  GLN GLN GLN GLN GLN GLN ASP GLN PRO GLU GLN SER GLU          
SEQRES  21 W  268  GLN PRO GLU GLN HIS GLN ASP LYS                              
SEQRES   1 X  156  MET SER MET SER SER THR VAL ILE LYS PHE ARG ALA GLY          
SEQRES   2 X  156  VAL CYS GLU TYR ASN GLU ASP SER ARG LEU CYS THR PRO          
SEQRES   3 X  156  ILE PRO VAL GLN GLY GLU ILE GLU ILE LYS PRO ASN GLU          
SEQRES   4 X  156  GLU GLU GLU LEU GLY PHE TRP ASP PHE GLU TRP ARG PRO          
SEQRES   5 X  156  THR GLU LYS PRO VAL GLY ARG GLU LEU ASP PRO ILE SER          
SEQRES   6 X  156  LEU ILE LEU ILE PRO GLY GLU THR MET TRP VAL PRO ILE          
SEQRES   7 X  156  LYS SER SER LYS SER GLY ARG ILE PHE ALA LEU VAL PHE          
SEQRES   8 X  156  SER SER ASN GLU ARG TYR PHE PHE TRP LEU GLN GLU LYS          
SEQRES   9 X  156  ASN SER GLY ASN LEU PRO LEU ASN GLU LEU SER ALA LYS          
SEQRES  10 X  156  ASP LYS GLU ILE TYR ASN LYS MET ILE GLY VAL LEU ASN          
SEQRES  11 X  156  ASN SER SER GLU SER ASP GLU GLU GLU SER ASN ASP GLU          
SEQRES  12 X  156  LYS GLN LYS ALA GLN ASP VAL ASP VAL SER MET GLN ASP          
SEQRES   1 Y   89  MET SER THR ASP VAL ALA ALA ALA GLN ALA GLN SER LYS          
SEQRES   2 Y   89  ILE ASP LEU THR LYS LYS LYS ASN GLU GLU ILE ASN LYS          
SEQRES   3 Y   89  LYS SER LEU GLU GLU ASP ASP GLU PHE GLU ASP PHE PRO          
SEQRES   4 Y   89  ILE ASP THR TRP ALA ASN GLY GLU THR ILE LYS SER ASN          
SEQRES   5 Y   89  ALA VAL THR GLN THR ASN ILE TRP GLU GLU ASN TRP ASP          
SEQRES   6 Y   89  ASP VAL GLU VAL ASP ASP ASP PHE THR ASN GLU LEU LYS          
SEQRES   7 Y   89  ALA GLU LEU ASP ARG TYR LYS ARG GLU ASN GLN                  
SEQRES   1 Z  993  MET VAL ASP GLU SER ASP LYS LYS GLN GLN THR ILE ASP          
SEQRES   2 Z  993  GLU GLN SER GLN ILE SER PRO GLU LYS GLN THR PRO ASN          
SEQRES   3 Z  993  LYS LYS ASP LYS LYS LYS GLU GLU GLU GLU GLN LEU SER          
SEQRES   4 Z  993  GLU GLU ASP ALA LYS LEU LYS THR ASP LEU GLU LEU LEU          
SEQRES   5 Z  993  VAL GLU ARG LEU LYS GLU ASP ASP SER SER LEU TYR GLU          
SEQRES   6 Z  993  ALA SER LEU ASN ALA LEU LYS GLU SER ILE LYS ASN SER          
SEQRES   7 Z  993  THR SER SER MET THR ALA VAL PRO LYS PRO LEU LYS PHE          
SEQRES   8 Z  993  LEU ARG PRO THR TYR PRO ASP LEU CYS SER ILE TYR ASP          
SEQRES   9 Z  993  LYS TRP THR ASP PRO ASN LEU LYS SER SER LEU ALA ASP          
SEQRES  10 Z  993  VAL LEU SER ILE LEU ALA MET THR TYR SER GLU ASN GLY          
SEQRES  11 Z  993  LYS HIS ASP SER LEU ARG TYR ARG LEU LEU SER ASP VAL          
SEQRES  12 Z  993  SER ASP PHE GLU GLY TRP GLY HIS GLU TYR ILE ARG HIS          
SEQRES  13 Z  993  LEU ALA LEU GLU ILE GLY GLU VAL TYR ASN ASP GLN VAL          
SEQRES  14 Z  993  GLU LYS ASP ALA GLU ASP GLU THR SER SER ASP GLY SER          
SEQRES  15 Z  993  LYS SER ASP GLY SER ALA ALA THR SER GLY PHE GLU PHE          
SEQRES  16 Z  993  SER LYS GLU ASP THR LEU ARG LEU CYS LEU ASP ILE VAL          
SEQRES  17 Z  993  PRO TYR PHE LEU LYS HIS ASN GLY GLU GLU ASP ALA VAL          
SEQRES  18 Z  993  ASP LEU LEU LEU GLU ILE GLU SER ILE ASP LYS LEU PRO          
SEQRES  19 Z  993  GLN PHE VAL ASP GLU ASN THR PHE GLN ARG VAL CYS GLN          
SEQRES  20 Z  993  TYR MET VAL ALA CYS VAL PRO LEU LEU PRO PRO PRO GLU          
SEQRES  21 Z  993  ASP VAL ALA PHE LEU LYS THR ALA TYR SER ILE TYR LEU          
SEQRES  22 Z  993  SER GLN ASN GLU LEU THR ASP ALA ILE ALA LEU ALA VAL          
SEQRES  23 Z  993  ARG LEU GLY GLU GLU ASP MET ILE ARG SER VAL PHE ASP          
SEQRES  24 Z  993  ALA THR SER ASP PRO VAL MET HIS LYS GLN LEU ALA TYR          
SEQRES  25 Z  993  ILE LEU ALA ALA GLN LYS THR SER PHE GLU TYR GLU GLY          
SEQRES  26 Z  993  VAL GLN ASP ILE ILE GLY ASN GLY LYS LEU SER GLU HIS          
SEQRES  27 Z  993  PHE LEU TYR LEU ALA LYS GLU LEU ASN LEU THR GLY PRO          
SEQRES  28 Z  993  LYS VAL PRO GLU ASP ILE TYR LYS SER HIS LEU ASP ASN          
SEQRES  29 Z  993  SER LYS SER VAL PHE SER SER ALA GLY LEU ASP SER ALA          
SEQRES  30 Z  993  GLN GLN ASN LEU ALA SER SER PHE VAL ASN GLY PHE LEU          
SEQRES  31 Z  993  ASN LEU GLY TYR CYS ASN ASP LYS LEU ILE VAL ASP ASN          
SEQRES  32 Z  993  ASP ASN TRP VAL TYR LYS THR LYS GLY ASP GLY MET THR          
SEQRES  33 Z  993  SER ALA VAL ALA SER ILE GLY SER ILE TYR GLN TRP ASN          
SEQRES  34 Z  993  LEU ASP GLY LEU GLN GLN LEU ASP LYS TYR LEU TYR VAL          
SEQRES  35 Z  993  ASP GLU PRO GLU VAL LYS ALA GLY ALA LEU LEU GLY ILE          
SEQRES  36 Z  993  GLY ILE SER ALA SER GLY VAL HIS ASP GLY GLU VAL GLU          
SEQRES  37 Z  993  PRO ALA LEU LEU LEU LEU GLN ASP TYR VAL THR ASN PRO          
SEQRES  38 Z  993  ASP THR LYS ILE SER SER ALA ALA ILE LEU GLY LEU GLY          
SEQRES  39 Z  993  ILE ALA PHE ALA GLY SER LYS ASN ASP GLU VAL LEU GLY          
SEQRES  40 Z  993  LEU LEU LEU PRO ILE ALA ALA SER THR ASP LEU PRO ILE          
SEQRES  41 Z  993  GLU THR ALA ALA MET ALA SER LEU ALA LEU ALA HIS VAL          
SEQRES  42 Z  993  PHE VAL GLY THR CYS ASN GLY ASP ILE THR THR SER ILE          
SEQRES  43 Z  993  MET ASP ASN PHE LEU GLU ARG THR ALA ILE GLU LEU LYS          
SEQRES  44 Z  993  THR ASP TRP VAL ARG PHE LEU ALA LEU ALA LEU GLY ILE          
SEQRES  45 Z  993  LEU TYR MET GLY GLN GLY GLU GLN VAL ASP ASP VAL LEU          
SEQRES  46 Z  993  GLU THR ILE SER ALA ILE GLU HIS PRO MET THR SER ALA          
SEQRES  47 Z  993  ILE GLU VAL LEU VAL GLY SER CYS ALA TYR THR GLY THR          
SEQRES  48 Z  993  GLY ASP VAL LEU LEU ILE GLN ASP LEU LEU HIS ARG LEU          
SEQRES  49 Z  993  THR PRO LYS ASN VAL LYS GLY GLU GLU ASP ALA ASP GLU          
SEQRES  50 Z  993  GLU GLU THR ALA GLU GLY GLN THR ASN SER ILE SER ASP          
SEQRES  51 Z  993  PHE LEU GLY GLU GLN VAL ASN GLU PRO THR LYS ASN GLU          
SEQRES  52 Z  993  GLU ALA GLU ILE GLU VAL ASP GLU MET GLU VAL ASP ALA          
SEQRES  53 Z  993  GLU GLY GLU GLU VAL GLU VAL LYS ALA GLU ILE THR GLU          
SEQRES  54 Z  993  LYS LYS ASN GLY GLU SER LEU GLU GLY GLU GLU ILE LYS          
SEQRES  55 Z  993  SER GLU GLU LYS LYS GLY LYS SER SER ASP LYS ASP ALA          
SEQRES  56 Z  993  THR THR ASP GLY LYS ASN ASP ASP GLU GLU GLU GLU LYS          
SEQRES  57 Z  993  GLU ALA GLY ILE VAL ASP GLU LEU ALA TYR ALA VAL LEU          
SEQRES  58 Z  993  GLY ILE ALA LEU ILE ALA LEU GLY GLU ASP ILE GLY LYS          
SEQRES  59 Z  993  GLU MET SER LEU ARG HIS PHE GLY HIS LEU MET HIS TYR          
SEQRES  60 Z  993  GLY ASN GLU HIS ILE ARG ARG MET VAL PRO LEU ALA MET          
SEQRES  61 Z  993  GLY ILE VAL SER VAL SER ASP PRO GLN MET LYS VAL PHE          
SEQRES  62 Z  993  ASP THR LEU THR ARG PHE SER HIS ASP ALA ASP LEU GLU          
SEQRES  63 Z  993  VAL SER MET ASN SER ILE PHE ALA MET GLY LEU CYS GLY          
SEQRES  64 Z  993  ALA GLY THR ASN ASN ALA ARG LEU ALA GLN LEU LEU ARG          
SEQRES  65 Z  993  GLN LEU ALA SER TYR TYR SER ARG GLU GLN ASP ALA LEU          
SEQRES  66 Z  993  PHE ILE THR ARG LEU ALA GLN GLY LEU LEU HIS LEU GLY          
SEQRES  67 Z  993  LYS GLY THR MET THR MET ASP VAL PHE ASN ASP ALA HIS          
SEQRES  68 Z  993  VAL LEU ASN LYS VAL THR LEU ALA SER ILE LEU THR THR          
SEQRES  69 Z  993  ALA VAL GLY LEU VAL SER PRO SER PHE MET LEU LYS HIS          
SEQRES  70 Z  993  HIS GLN LEU PHE TYR MET LEU ASN ALA GLY ILE ARG PRO          
SEQRES  71 Z  993  LYS PHE ILE LEU ALA LEU ASN ASP GLU GLY GLU PRO ILE          
SEQRES  72 Z  993  LYS VAL ASN VAL ARG VAL GLY GLN ALA VAL GLU THR VAL          
SEQRES  73 Z  993  GLY GLN ALA GLY ARG PRO LYS LYS ILE THR GLY TRP ILE          
SEQRES  74 Z  993  THR GLN SER THR PRO VAL LEU LEU ASN HIS GLY GLU ARG          
SEQRES  75 Z  993  ALA GLU LEU GLU THR ASP GLU TYR ILE SER TYR THR SER          
SEQRES  76 Z  993  HIS ILE GLU GLY VAL VAL ILE LEU LYS LYS ASN PRO ASP          
SEQRES  77 Z  993  TYR ARG GLU GLU GLU                                          
HELIX    1   1 SER 1   48  TYR 1   70  1                                  23    
HELIX    2   2 SER 1   74  ASN 1   89  1                                  16    
HELIX    3   3 GLY 1  130  PHE 1  133  5                                   4    
HELIX    4   4 ILE 1  134  PHE 1  142  1                                   9    
HELIX    5   5 SER 1  147  ASP 1  166  1                                  20    
HELIX    6   6 TYR 1  189  GLU 1  194  1                                   6    
HELIX    7   7 THR 2   48  SER 2   71  1                                  24    
HELIX    8   8 ARG 2   75  TYR 2   90  1                                  16    
HELIX    9   9 GLY 2  130  TRP 2  142  1                                  13    
HELIX   10  10 THR 2  147  ASP 2  166  1                                  20    
HELIX   11  11 LEU 3   47  GLU 3   70  1                                  24    
HELIX   12  12 GLU 3   74  ARG 3   89  1                                  16    
HELIX   13  13 ALA 3  133  TYR 3  145  1                                  13    
HELIX   14  14 GLU 3  150  ASP 3  167  1                                  18    
HELIX   15  15 GLU 4   48  ASP 4   71  1                                  24    
HELIX   16  16 SER 4   75  ILE 4   91  1                                  17    
HELIX   17  17 SER 4  135  TYR 4  147  1                                  13    
HELIX   18  18 THR 4  152  MET 4  171  1                                  20    
HELIX   19  19 GLY 5   48  GLU 5   70  1                                  23    
HELIX   20  20 SER 5   75  TYR 5   90  1                                  16    
HELIX   21  21 GLY 5  132  ASN 5  143  1                                  12    
HELIX   22  22 SER 5  149  ASP 5  168  1                                  20    
HELIX   23  23 VAL 5  193  GLU 5  204  1                                  12    
HELIX   24  24 PHE 6   48  HIS 6   70  1                                  23    
HELIX   25  25 SER 6   76  GLY 6   90  1                                  15    
HELIX   26  26 ALA 6  133  VAL 6  145  1                                  13    
HELIX   27  27 SER 6  167  HIS 6  186  1                                  20    
HELIX   28  28 ASP 7   48  TYR 7   68  1                                  21    
HELIX   29  29 GLU 7   80  LYS 7   98  1                                  19    
HELIX   30  30 GLY 7  137  ALA 7  143  1                                   7    
HELIX   31  31 ALA 7  143  ARG 7  148  1                                   6    
HELIX   32  32 ASP 7  156  THR 7  160  5                                   5    
HELIX   33  33 THR 7  161  ASP 7  180  1                                  20    
HELIX   34  34 TRP 7  211  ILE 7  217  5                                   7    
HELIX   35  35 LEU A   25  ALA A   34  1                                  10    
HELIX   36  36 PRO A   86  TYR A  108  1                                  23    
HELIX   37  37 PRO A  113  ARG A  131  1                                  19    
HELIX   38  38 LYS A  174  LYS A  190  1                                  17    
HELIX   39  39 SER A  198  GLY A  215  1                                  18    
HELIX   40  40 SER A  237  ALA A  249  1                                  13    
HELIX   41  41 LEU B   18  GLN B   30  1                                  13    
HELIX   42  42 MET B   78  SER B   96  1                                  19    
HELIX   43  43 PRO B  106  SER B  124  1                                  19    
HELIX   44  44 GLY B  167  TRP B  179  1                                  13    
HELIX   45  45 GLU B  184  VAL B  200  1                                  17    
HELIX   46  46 ASN B  218  LEU B  222  5                                   5    
HELIX   47  47 THR B  239  ALA B  249  1                                  11    
HELIX   48  48 LEU C   19  SER C   30  1                                  12    
HELIX   49  49 LEU C   80  ASN C  103  1                                  24    
HELIX   50  50 PRO C  107  HIS C  125  1                                  19    
HELIX   51  51 ASN C  168  TYR C  180  1                                  13    
HELIX   52  52 LYS C  185  LYS C  199  1                                  15    
HELIX   53  53 LYS C  231  THR C  242  1                                  12    
HELIX   54  54 ILE D   17  GLY D   30  1                                  14    
HELIX   55  55 LEU D   78  GLU D  101  1                                  24    
HELIX   56  56 THR D  105  SER D  123  1                                  19    
HELIX   57  57 ASN D  167  GLU D  176  1                                  10    
HELIX   58  58 THR D  187  GLN D  204  1                                  18    
HELIX   59  59 SER D  225  LYS D  240  1                                  16    
HELIX   60  60 LEU E   21  ILE E   31  1                                  11    
HELIX   61  61 LYS E   32  GLY E   34  5                                   3    
HELIX   62  62 THR E   82  ASP E  104  1                                  23    
HELIX   63  63 ASN E  108  ASP E  118  1                                  11    
HELIX   64  64 GLY E  175  TRP E  187  1                                  13    
HELIX   65  65 THR E  192  MET E  208  1                                  17    
HELIX   66  66 ASP E  232  ALA E  248  1                                  17    
HELIX   67  67 PHE F    2  ASP F    7  1                                   6    
HELIX   68  68 LEU F   19  LYS F   30  1                                  12    
HELIX   69  69 LEU F   77  PHE F   99  1                                  23    
HELIX   70  70 ALA F  104  THR F  120  1                                  17    
HELIX   71  71 ARG F  164  ILE F  182  1                                  19    
HELIX   72  72 ASN F  185  LEU F  201  1                                  17    
HELIX   73  73 GLU F  228  ILE F  234  5                                   7    
HELIX   74  74 ASN G   20  ASN G   32  1                                  13    
HELIX   75  75 LEU G   80  LYS G  103  1                                  24    
HELIX   76  76 PRO G  107  HIS G  122  1                                  16    
HELIX   77  77 GLY G  167  HIS G  182  1                                  16    
HELIX   78  78 SER G  187  HIS G  203  1                                  17    
HELIX   79  79 GLU G  204  ASN G  206  5                                   3    
HELIX   80  80 GLY G  232  ILE G  246  1                                  15    
HELIX   81  81 LEU H   49  GLY H   75  1                                  27    
HELIX   82  82 CYS H  214  VAL H  225  1                                  12    
HELIX   83  83 VAL H  225  SER H  231  1                                   7    
HELIX   84  84 PRO H  232  GLY H  239  1                                   8    
HELIX   85  85 GLY H  255  THR H  267  1                                  13    
HELIX   86  86 SER H  277  VAL H  280  5                                   4    
HELIX   87  87 GLY H  285  LYS H  301  1                                  17    
HELIX   88  88 ASP H  326  GLY H  342  1                                  17    
HELIX   89  89 ASP H  362  ARG H  367  1                                   6    
HELIX   90  90 ASP H  381  SER H  393  1                                  13    
HELIX   91  91 ARG H  403  ARG H  409  1                                   7    
HELIX   92  92 THR H  415  ARG H  434  1                                  20    
HELIX   93  93 THR H  439  LYS H  455  1                                  17    
HELIX   94  94 PHE I   75  GLY I  101  1                                  27    
HELIX   95  95 ASP I  137  LEU I  141  5                                   5    
HELIX   96  96 ASP I  165  SER I  169  5                                   5    
HELIX   97  97 LEU I  187  VAL I  198  1                                  12    
HELIX   98  98 VAL I  198  HIS I  204  1                                   7    
HELIX   99  99 PRO I  205  GLY I  212  1                                   8    
HELIX  100 100 GLY I  228  THR I  240  1                                  13    
HELIX  101 101 SER I  250  ILE I  253  5                                   4    
HELIX  102 102 ASP I  259  ASN I  274  1                                  16    
HELIX  103 103 GLU I  299  PHE I  316  1                                  18    
HELIX  104 104 ASP I  335  ARG I  340  1                                   6    
HELIX  105 105 ASP I  354  LYS I  368  1                                  15    
HELIX  106 106 ASN I  376  LYS I  384  1                                   9    
HELIX  107 107 SER I  388  GLU I  406  1                                  19    
HELIX  108 108 THR I  412  VAL I  428  1                                  17    
HELIX  109 109 GLU J   24  LEU J   65  1                                  42    
HELIX  110 110 ASP J  131  SER J  135  5                                   5    
HELIX  111 111 LEU J  153  ILE J  164  1                                  12    
HELIX  112 112 ILE J  164  HIS J  170  1                                   7    
HELIX  113 113 HIS J  170  GLY J  178  1                                   9    
HELIX  114 114 GLY J  194  ASP J  207  1                                  14    
HELIX  115 115 GLY J  224  HIS J  240  1                                  17    
HELIX  116 116 SER J  266  ASP J  280  1                                  15    
HELIX  117 117 SER J  320  ARG J  333  1                                  14    
HELIX  118 118 ASN J  342  MET J  350  1                                   9    
HELIX  119 119 SER J  354  GLU J  372  1                                  19    
HELIX  120 120 THR J  378  GLN J  394  1                                  17    
HELIX  121 121 TYR K   48  GLN K   90  1                                  43    
HELIX  122 122 LEU K  177  VAL K  188  1                                  12    
HELIX  123 123 VAL K  188  GLN K  194  1                                   7    
HELIX  124 124 ALA K  195  GLY K  202  1                                   8    
HELIX  125 125 GLY K  218  THR K  230  1                                  13    
HELIX  126 126 GLU K  249  ASN K  264  1                                  16    
HELIX  127 127 GLU K  273  ILE K  277  5                                   5    
HELIX  128 128 ARG K  290  PHE K  306  1                                  17    
HELIX  129 129 ASP K  325  ARG K  330  1                                   6    
HELIX  130 130 ASP K  345  MET K  360  1                                  16    
HELIX  131 131 ASP K  367  ASN K  375  1                                   9    
HELIX  132 132 SER K  379  LYS K  397  1                                  19    
HELIX  133 133 LEU K  403  LYS K  416  1                                  14    
HELIX  134 134 HIS L   67  GLN L   99  1                                  33    
HELIX  135 135 LEU L  186  GLY L  211  1                                  26    
HELIX  136 136 PRO L  223  THR L  226  5                                   4    
HELIX  137 137 GLY L  227  GLY L  240  1                                  14    
HELIX  138 138 SER L  249  ILE L  251  5                                   3    
HELIX  139 139 GLY L  257  HIS L  273  1                                  17    
HELIX  140 140 ASP L  298  GLY L  314  1                                  17    
HELIX  141 141 ASP L  334  ARG L  339  1                                   6    
HELIX  142 142 ASN L  353  LYS L  367  1                                  15    
HELIX  143 143 ASP L  375  SER L  383  1                                   9    
HELIX  144 144 ASN L  387  ASP L  405  1                                  19    
HELIX  145 145 ASN L  411  VAL L  425  1                                  15    
HELIX  146 146 ILE M   41  GLN M   74  1                                  34    
HELIX  147 147 ASP M  136  LEU M  140  5                                   5    
HELIX  148 148 LEU M  186  ILE M  197  1                                  12    
HELIX  149 149 ILE M  197  ARG M  203  1                                   7    
HELIX  150 150 ARG M  203  GLY M  211  1                                   9    
HELIX  151 151 GLY M  227  ASN M  240  1                                  14    
HELIX  152 152 PRO M  249  LEU M  251  5                                   3    
HELIX  153 153 GLY M  257  LYS M  273  1                                  17    
HELIX  154 154 ARG M  299  GLY M  314  1                                  16    
HELIX  155 155 SER M  353  MET M  368  1                                  16    
HELIX  156 156 ASN M  375  THR M  383  1                                   9    
HELIX  157 157 ASN M  387  GLY M  406  1                                  20    
HELIX  158 158 LYS M  411  GLU M  421  1                                  11    
HELIX  159 159 ALA N    6  ARG N   14  1                                   9    
HELIX  160 160 GLN N   17  ASN N   29  1                                  13    
HELIX  161 161 VAL N   31  SER N   40  1                                  10    
HELIX  162 162 GLU N   42  ASP N   51  1                                  10    
HELIX  163 163 ASP N   57  GLY N   73  1                                  17    
HELIX  164 164 GLU N   74  LYS N   86  1                                  13    
HELIX  165 165 ASP N   87  PHE N   89  5                                   3    
HELIX  166 166 SER N   95  ASP N  120  1                                  26    
HELIX  167 167 GLN N  122  LYS N  126  5                                   5    
HELIX  168 168 ASP N  130  ALA N  147  1                                  18    
HELIX  169 169 GLU N  149  GLY N  160  1                                  12    
HELIX  170 170 LEU N  163  SER N  172  1                                  10    
HELIX  171 171 SER N  178  THR N  196  1                                  19    
HELIX  172 172 ASN N  199  MET N  217  1                                  19    
HELIX  173 173 ASP N  221  ASN N  233  1                                  13    
HELIX  174 174 ASP N  234  GLU N  248  1                                  15    
HELIX  175 175 ASP N  250  ALA N  265  1                                  16    
HELIX  176 176 SER N  266  GLY N  281  1                                  16    
HELIX  177 177 ASP N  283  LEU N  290  1                                   8    
HELIX  178 178 GLY N  292  ASN N  306  1                                  15    
HELIX  179 179 ASP N  310  LEU N  321  1                                  12    
HELIX  180 180 SER N  326  HIS N  340  1                                  15    
HELIX  181 181 ASN N  346  ASN N  352  1                                   7    
HELIX  182 182 LEU N  353  ALA N  359  1                                   7    
HELIX  183 183 GLN N  360  SER N  370  1                                  11    
HELIX  184 184 SER N  370  HIS N  375  1                                   6    
HELIX  185 185 LEU N  380  MET N  386  1                                   7    
HELIX  186 186 ALA N  387  LEU N  390  5                                   4    
HELIX  187 187 SER N  397  TYR N  412  1                                  16    
HELIX  188 188 GLY N  416  ASN N  430  1                                  15    
HELIX  189 189 ASP N  436  ALA N  454  1                                  19    
HELIX  190 190 ASN N  459  ASN N  472  1                                  14    
HELIX  191 191 THR N  476  MET N  489  1                                  14    
HELIX  192 192 LYS N  494  THR N  508  1                                  15    
HELIX  193 193 HIS N  510  ASN N  525  1                                  16    
HELIX  194 194 ARG N  528  LEU N  531  5                                   4    
HELIX  195 195 ALA N  532  SER N  542  1                                  11    
HELIX  196 196 GLU N  544  TYR N  559  1                                  16    
HELIX  197 197 ASN N  564  ASP N  578  1                                  15    
HELIX  198 198 ASN N  580  ALA N  590  1                                  11    
HELIX  199 199 ALA N  590  LEU N  595  1                                   6    
HELIX  200 200 THR N  601  VAL N  606  1                                   6    
HELIX  201 201 LEU N  608  SER N  612  5                                   5    
HELIX  202 202 ASN N  614  CYS N  629  1                                  16    
HELIX  203 203 LEU N  634  ASP N  642  1                                   9    
HELIX  204 204 PRO N  643  ASP N  647  5                                   5    
HELIX  205 205 VAL N  649  LEU N  664  1                                  16    
HELIX  206 206 GLN N  674  ASN N  688  1                                  15    
HELIX  207 207 GLU N  692  ASN N  707  1                                  16    
HELIX  208 208 ALA N  708  ARG N  711  5                                   4    
HELIX  209 209 ASP N  726  SER N  737  1                                  12    
HELIX  210 210 LEU N  745  LEU N  751  5                                   7    
HELIX  211 211 PHE O    2  ARG O   15  1                                  14    
HELIX  212 212 HIS O   23  GLU O   34  1                                  12    
HELIX  213 213 GLU O   43  PHE O   49  5                                   7    
HELIX  214 214 ARG O   58  ILE O   73  1                                  16    
HELIX  215 215 GLN O   75  TYR O   81  1                                   7    
HELIX  216 216 LEU O   83  SER O   89  1                                   7    
HELIX  217 217 ASP O   91  LYS O  103  1                                  13    
HELIX  218 218 GLU O  108  LYS O  112  5                                   5    
HELIX  219 219 ASP O  124  ASN O  141  1                                  18    
HELIX  220 220 ASP O  142  LYS O  159  1                                  18    
HELIX  221 221 LEU O  165  LYS O  182  1                                  18    
HELIX  222 222 ASP O  184  THR O  198  1                                  15    
HELIX  223 223 LEU O  199  THR O  203  5                                   5    
HELIX  224 224 THR O  206  GLY O  224  1                                  19    
HELIX  225 225 PHE O  230  HIS O  235  5                                   6    
HELIX  226 226 TYR O  248  GLY O  261  1                                  14    
HELIX  227 227 ASP O  262  ILE O  270  1                                   9    
HELIX  228 228 LYS O  271  ILE O  277  1                                   7    
HELIX  229 229 ILE O  279  VAL O  300  1                                  22    
HELIX  230 230 PHE O  310  HIS O  318  1                                   9    
HELIX  231 231 PRO O  320  LEU O  334  1                                  15    
HELIX  232 232 SER O  359  ARG O  387  1                                  29    
HELIX  233 233 ALA P   28  THR P   46  1                                  19    
HELIX  234 234 SER P   55  ASN P   70  1                                  16    
HELIX  235 235 LYS P   71  LYS P   84  1                                  14    
HELIX  236 236 LEU P   89  LYS P  108  1                                  20    
HELIX  237 237 SER P  109  ILE P  122  1                                  14    
HELIX  238 238 GLU P  133  GLY P  151  1                                  19    
HELIX  239 239 LYS P  152  TYR P  168  1                                  17    
HELIX  240 240 GLU P  172  GLY P  191  1                                  20    
HELIX  241 241 ASP P  192  ASN P  210  1                                  19    
HELIX  242 242 TYR P  213  ARG P  232  1                                  20    
HELIX  243 243 GLU P  233  SER P  252  1                                  20    
HELIX  244 244 ASP P  253  SER P  271  1                                  19    
HELIX  245 245 LEU P  276  LYS P  283  1                                   8    
HELIX  246 246 LYS P  283  ASN P  288  1                                   6    
HELIX  247 247 LEU P  290  ASN P  306  1                                  17    
HELIX  248 248 ARG P  310  TYR P  318  1                                   9    
HELIX  249 249 ALA P  333  TYR P  356  1                                  24    
HELIX  250 250 LEU P  362  LEU P  369  1                                   8    
HELIX  251 251 THR P  372  GLY P  387  1                                  16    
HELIX  252 252 ASN P  407  LEU P  442  1                                  36    
HELIX  253 253 LEU Q    3  LYS Q   18  1                                  16    
HELIX  254 254 GLN Q   19  LYS Q   33  1                                  15    
HELIX  255 255 ASP Q   48  GLY Q   69  1                                  22    
HELIX  256 256 ALA Q   70  GLU Q   83  1                                  14    
HELIX  257 257 TYR Q   84  PHE Q   88  5                                   5    
HELIX  258 258 ALA Q   89  GLN Q  106  1                                  18    
HELIX  259 259 SER Q  110  ARG Q  127  1                                  18    
HELIX  260 260 HIS Q  135  LYS Q  149  1                                  15    
HELIX  261 261 GLN Q  150  LYS Q  166  1                                  17    
HELIX  262 262 ASP Q  170  LEU Q  188  1                                  19    
HELIX  263 263 ASN Q  190  ASN Q  206  1                                  17    
HELIX  264 264 PRO Q  211  ASP Q  229  1                                  19    
HELIX  265 265 ASP Q  231  THR Q  250  1                                  20    
HELIX  266 266 THR Q  251  ASN Q  253  5                                   3    
HELIX  267 267 SER Q  254  ASN Q  273  1                                  20    
HELIX  268 268 LEU Q  274  ALA Q  284  1                                  11    
HELIX  269 269 SER Q  293  ARG Q  309  1                                  17    
HELIX  270 270 SER Q  310  TYR Q  321  1                                  12    
HELIX  271 271 TYR Q  321  MET Q  326  1                                   6    
HELIX  272 272 ASP Q  328  ILE Q  351  1                                  24    
HELIX  273 273 ILE Q  359  GLY Q  367  1                                   9    
HELIX  274 274 ASP Q  369  ASP Q  383  1                                  15    
HELIX  275 275 THR Q  408  SER Q  431  1                                  24    
HELIX  276 276 ASN R   23  GLN R   35  1                                  13    
HELIX  277 277 SER R   39  LYS R   55  1                                  17    
HELIX  278 278 MET R   59  TYR R   70  1                                  12    
HELIX  279 279 GLU R   97  ASP R  124  1                                  28    
HELIX  280 280 LEU R  128  GLY R  145  1                                  18    
HELIX  281 281 LYS R  147  LYS R  160  1                                  14    
HELIX  282 282 GLY R  165  ASN R  182  1                                  18    
HELIX  283 283 GLN R  184  MET R  197  1                                  14    
HELIX  284 284 ASP R  203  ARG R  222  1                                  20    
HELIX  285 285 PHE R  224  VAL R  232  1                                   9    
HELIX  286 286 SER R  245  LEU R  261  1                                  17    
HELIX  287 287 GLU R  262  VAL R  270  1                                   9    
HELIX  288 288 SER R  273  THR R  283  1                                  11    
HELIX  289 289 SER R  290  SER R  299  1                                  10    
HELIX  290 290 SER R  303  LEU R  316  1                                  14    
HELIX  291 291 HIS R  325  SER R  344  1                                  20    
HELIX  292 292 LEU R  350  PHE R  357  1                                   8    
HELIX  293 293 SER R  360  LYS R  375  1                                  16    
HELIX  294 294 ASN R  395  VAL R  421  1                                  27    
HELIX  295 295 LYS S  126  LEU S  144  1                                  19    
HELIX  296 296 LEU S  155  ILE S  164  1                                  10    
HELIX  297 297 ASN S  180  HIS S  191  1                                  12    
HELIX  298 298 ASP S  204  ALA S  221  1                                  18    
HELIX  299 299 ASP S  226  ASN S  244  1                                  19    
HELIX  300 300 SER S  249  GLU S  258  1                                  10    
HELIX  301 301 SER S  265  GLN S  283  1                                  19    
HELIX  302 302 ASP S  285  ILE S  297  1                                  13    
HELIX  303 303 LEU S  307  GLY S  325  1                                  19    
HELIX  304 304 MET S  338  GLY S  355  1                                  18    
HELIX  305 305 ASP S  356  TYR S  367  1                                  12    
HELIX  306 306 TYR S  367  ASP S  375  1                                   9    
HELIX  307 307 TYR S  377  ILE S  394  1                                  18    
HELIX  308 308 SER S  403  SER S  415  1                                  13    
HELIX  309 309 THR S  418  GLY S  430  1                                  13    
HELIX  310 310 GLU S  455  SER S  478  1                                  24    
HELIX  311 311 GLU T    6  ASN T   17  1                                  12    
HELIX  312 312 ASP T   19  LYS T   36  1                                  18    
HELIX  313 313 ASP T   54  PHE T   73  1                                  20    
HELIX  314 314 ASN T   74  PHE T   90  1                                  17    
HELIX  315 315 LYS T  101  GLN T  116  1                                  16    
HELIX  316 316 ASN T  118  ASP T  130  1                                  13    
HELIX  317 317 LYS T  131  ASP T  139  1                                   9    
HELIX  318 318 ASP T  139  GLY T  155  1                                  17    
HELIX  319 319 SER T  156  GLY T  167  1                                  12    
HELIX  320 320 GLY T  167  GLU T  173  1                                   7    
HELIX  321 321 PHE T  174  TYR T  197  1                                  24    
HELIX  322 322 LEU T  202  LEU T  209  1                                   8    
HELIX  323 323 ASN T  213  ASN T  225  1                                  13    
HELIX  324 324 GLU T  253  ASN T  272  1                                  20    
HELIX  325 325 ALA U   11  THR U   25  1                                  15    
HELIX  326 326 HIS U   70  LYS U   81  1                                  12    
HELIX  327 327 LYS U  105  LYS U  112  1                                   8    
HELIX  328 328 GLU U  164  ARG U  176  1                                  13    
HELIX  329 329 ILE U  188  ILE U  215  1                                  28    
HELIX  330 330 HIS U  223  ASP U  231  1                                   9    
HELIX  331 331 ASN U  260  ALA U  264  5                                   5    
HELIX  332 332 LEU U  265  ASP U  308  1                                  44    
HELIX  333 333 SER V   30  GLY V   44  1                                  15    
HELIX  334 334 SER V   79  VAL V   83  5                                   5    
HELIX  335 335 ASP V   84  GLN V   97  1                                  14    
HELIX  336 336 SER V  119  GLU V  130  1                                  12    
HELIX  337 337 ILE V  144  LYS V  148  5                                   5    
HELIX  338 338 LYS V  182  LEU V  192  1                                  11    
HELIX  339 339 THR V  206  MET V  214  1                                   9    
HELIX  340 340 TYR V  230  ARG V  269  1                                  40    
HELIX  341 341 PRO V  276  ALA V  298  1                                  23    
HELIX  342 342 THR W   24  ASN W   44  1                                  21    
HELIX  343 343 PHE W   69  LEU W   76  1                                   8    
HELIX  344 344 HIS W   86  LEU W   98  1                                  13    
HELIX  345 345 SER W  121  ASN W  136  1                                  16    
HELIX  346 346 GLU W  152  ASN W  162  1                                  11    
HELIX  347 347 LEU W  180  SER W  188  1                                   9    
HELIX  348 348 ASP X  118  ASN X  131  1                                  14    
HELIX  349 349 ASP Y   71  ASN Y   88  1                                  18    
HELIX  350 350 LEU Z   52  GLU Z   58  1                                   7    
HELIX  351 351 ASP Z   60  ILE Z   75  1                                  16    
HELIX  352 352 LYS Z   87  ARG Z   93  1                                   7    
HELIX  353 353 THR Z   95  LYS Z  105  1                                  11    
HELIX  354 354 ASN Z  110  SER Z  127  1                                  18    
HELIX  355 355 ASP Z  133  ARG Z  138  1                                   6    
HELIX  356 356 GLY Z  150  ASP Z  175  1                                  26    
HELIX  357 357 LYS Z  197  HIS Z  214  1                                  18    
HELIX  358 358 GLY Z  216  ILE Z  227  1                                  12    
HELIX  359 359 ASP Z  231  ASP Z  238  1                                   8    
HELIX  360 360 THR Z  241  LEU Z  256  1                                  16    
HELIX  361 361 VAL Z  262  ALA Z  268  1                                   7    
HELIX  362 362 ALA Z  268  GLN Z  275  1                                   8    
HELIX  363 363 GLU Z  277  GLY Z  289  1                                  13    
HELIX  364 364 GLU Z  290  THR Z  301  1                                  12    
HELIX  365 365 ASP Z  303  ALA Z  316  1                                  14    
HELIX  366 366 LYS Z  318  TYR Z  323  1                                   6    
HELIX  367 367 ASP Z  328  GLY Z  333  1                                   6    
HELIX  368 368 LEU Z  342  LEU Z  348  5                                   7    
HELIX  369 369 VAL Z  353  SER Z  365  1                                  13    
HELIX  370 370 SER Z  376  ASN Z  391  1                                  16    
HELIX  371 371 ASP Z  397  ASN Z  403  1                                   7    
HELIX  372 372 ASN Z  403  THR Z  410  1                                   8    
HELIX  373 373 ASP Z  413  GLN Z  427  1                                  15    
HELIX  374 374 GLY Z  432  TYR Z  441  1                                  10    
HELIX  375 375 GLU Z  444  SER Z  460  1                                  17    
HELIX  376 376 ALA Z  470  ASN Z  480  1                                  11    
HELIX  377 377 ASP Z  482  PHE Z  497  1                                  16    
HELIX  378 378 ASN Z  502  SER Z  515  1                                  14    
HELIX  379 379 ASP Z  517  THR Z  522  1                                   6    
HELIX  380 380 ALA Z  526  PHE Z  534  1                                   9    
HELIX  381 381 GLY Z  540  ARG Z  553  1                                  14    
HELIX  382 382 LYS Z  559  TYR Z  574  1                                  16    
HELIX  383 383 GLN Z  577  GLN Z  580  5                                   4    
HELIX  384 384 VAL Z  581  ILE Z  591  1                                  11    
HELIX  385 385 HIS Z  593  TYR Z  608  1                                  16    
HELIX  386 386 ASP Z  613  THR Z  625  1                                  13    
HELIX  387 387 LEU Z  736  ALA Z  747  1                                  12    
HELIX  388 388 GLU Z  750  TYR Z  767  1                                  18    
HELIX  389 389 ASN Z  769  SER Z  784  1                                  16    
HELIX  390 390 GLN Z  789  HIS Z  801  1                                  13    
HELIX  391 391 ASP Z  804  ALA Z  820  1                                  17    
HELIX  392 392 ARG Z  826  SER Z  836  1                                  11    
HELIX  393 393 GLU Z  841  HIS Z  856  1                                  16    
HELIX  394 394 ASN Z  874  VAL Z  886  1                                  13    
HELIX  395 395 HIS Z  897  ALA Z  906  5                                  10    
HELIX  396 396 ASN Z  986  ARG Z  990  5                                   5    
SHEET    1  1A 5 ALA 1 125  GLY 1 128  0                                        
SHEET    2  1A 5 SER 1   2  THR 1   7 -1  O  ILE 1   3   N  ALA 1 127           
SHEET    3  1A 5 GLY 1  11  ASP 1  17 -1  O  ILE 1  13   N  VAL 1   6           
SHEET    4  1A 5 ILE 1 173  THR 1 179 -1  O  ARG 1 174   N  ALA 1  16           
SHEET    5  1A 5 GLY 1 182  PHE 1 188 -1  O  GLY 1 182   N  THR 1 179           
SHEET    1  1B 2 THR 1  20  THR 1  22  0                                        
SHEET    2  1B 2 TYR 1  25  ASN 1  28 -1  O  TYR 1  25   N  THR 1  22           
SHEET    1  1C 5 LEU 1  34  HIS 1  38  0                                        
SHEET    2  1C 5 ILE 1  41  GLY 1  47 -1  O  ILE 1  41   N  VAL 1  37           
SHEET    3  1C 5 ALA 1  95  TYR 1 102 -1  O  GLY 1  96   N  SER 1  46           
SHEET    4  1C 5 GLY 1 108  ILE 1 113 -1  O  GLU 1 109   N  GLY 1 101           
SHEET    5  1C 5 HIS 1 120  LYS 1 121 -1  O  HIS 1 120   N  THR 1 112           
SHEET    1  2A 5 TYR 2 124  GLY 2 128  0                                        
SHEET    2  2A 5 THR 2   2  PHE 2   8 -1  O  ILE 2   3   N  LEU 2 127           
SHEET    3  2A 5 GLY 2  11  ASP 2  17 -1  O  GLY 2  11   N  PHE 2   8           
SHEET    4  2A 5 VAL 2 173  GLU 2 179 -1  O  ASP 2 174   N  ALA 2  16           
SHEET    5  2A 5 GLU 2 185  LEU 2 191 -1  O  GLU 2 185   N  VAL 2 177           
SHEET    1  2B 2 SER 2  20  GLN 2  22  0                                        
SHEET    2  2B 2 ILE 2  25  ASP 2  28 -1  O  ILE 2  25   N  GLN 2  22           
SHEET    1  2C 5 LEU 2  34  SER 2  38  0                                        
SHEET    2  2C 5 ILE 2  41  GLY 2  47 -1  O  ILE 2  41   N  ILE 2  37           
SHEET    3  2C 5 ALA 2  96  ASP 2 104 -1  O  TYR 2  97   N  ALA 2  46           
SHEET    4  2C 5 GLY 2 107  ILE 2 113 -1  O  GLY 2 107   N  ASP 2 104           
SHEET    5  2C 5 THR 2 119  VAL 2 121 -1  O  ASP 2 120   N  SER 2 112           
SHEET    1  2D 6 LYS 2 214  VAL 2 218  0                                        
SHEET    2  2D 6 VAL 3 186  LEU 3 191 -1  O  VAL 3 186   N  VAL 2 218           
SHEET    3  2D 6 ALA 3 176  ILE 3 181 -1  O  ALA 3 176   N  LEU 3 191           
SHEET    4  2D 6 VAL 3  12  ASP 3  17 -1  O  VAL 3  12   N  ILE 3 181           
SHEET    5  2D 6 ILE 3   2  THR 3   7 -1  O  ILE 3   2   N  ASP 3  17           
SHEET    6  2D 6 PHE 3 127  GLY 3 131 -1  O  ILE 3 128   N  ALA 3   5           
SHEET    1  3A 2 LEU 3  20  SER 3  22  0                                        
SHEET    2  3A 2 LEU 3  25  SER 3  28 -1  O  LEU 3  25   N  SER 3  22           
SHEET    1  3B 5 ILE 3  34  TYR 3  37  0                                        
SHEET    2  3B 5 VAL 3  40  GLY 3  46 -1  O  VAL 3  40   N  TYR 3  37           
SHEET    3  3B 5 VAL 3  96  ILE 3 103 -1  O  GLY 3  97   N  THR 3  45           
SHEET    4  3B 5 PRO 3 110  PHE 3 115 -1  O  PHE 3 111   N  GLY 3 102           
SHEET    5  3B 5 ILE 3 121  ALA 3 124 -1  O  ASP 3 122   N  GLY 3 114           
SHEET    1  4A 5 TYR 4 129  GLY 4 130  0                                        
SHEET    2  4A 5 ILE 4   3  ARG 4   7 -1  O  GLY 4   5   N  GLY 4 130           
SHEET    3  4A 5 VAL 4  12  SER 4  17 -1  O  ILE 4  13   N  ILE 4   6           
SHEET    4  4A 5 VAL 4 178  ASP 4 184 -1  O  ILE 4 179   N  SER 4  16           
SHEET    5  4A 5 GLY 4 187  VAL 4 191 -1  O  GLY 4 187   N  ASP 4 184           
SHEET    1  4B 2 VAL 4  20  ARG 4  22  0                                        
SHEET    2  4B 2 SER 4  25  LYS 4  28 -1  O  SER 4  25   N  ARG 4  22           
SHEET    1  4C 5 THR 4  34  SER 4  38  0                                        
SHEET    2  4C 5 THR 4  41  GLY 4  47 -1  O  THR 4  41   N  SER 4  38           
SHEET    3  4C 5 VAL 4  99  ASP 4 107 -1  O  ASN 4 100   N  ALA 4  46           
SHEET    4  4C 5 LYS 4 112  ILE 4 118 -1  O  LYS 4 112   N  ASP 4 107           
SHEET    5  4C 5 LYS 4 124  GLU 4 126 -1  O  VAL 4 125   N  GLN 4 117           
SHEET    1  5A 5 ILE 5 126  GLY 5 130  0                                        
SHEET    2  5A 5 THR 5   2  PHE 5   8 -1  O  THR 5   3   N  VAL 5 129           
SHEET    3  5A 5 GLY 5  11  SER 5  18 -1  O  GLY 5  11   N  PHE 5   8           
SHEET    4  5A 5 SER 5 174  THR 5 181 -1  O  SER 5 174   N  SER 5  18           
SHEET    5  5A 5 GLY 5 184  ASP 5 192 -1  O  GLY 5 184   N  THR 5 181           
SHEET    1  5B 2 ALA 5  20  ALA 5  22  0                                        
SHEET    2  5B 2 TRP 5  25  SER 5  28 -1  O  TRP 5  25   N  ALA 5  22           
SHEET    1  5C 5 VAL 5  34  ASN 5  38  0                                        
SHEET    2  5C 5 LEU 5  41  THR 5  44 -1  O  LEU 5  41   N  ASN 5  38           
SHEET    3  5C 5 GLY 5  98  THR 5 105 -1  O  CYS 5 102   N  LEU 5  42           
SHEET    4  5C 5 GLY 5 109  ASP 5 116 -1  O  GLY 5 109   N  THR 5 105           
SHEET    5  5C 5 ARG 5 121  LYS 5 123 -1  O  LEU 5 122   N  TYR 5 114           
SHEET    1  6A 5 CYS 6 127  GLY 6 131  0                                        
SHEET    2  6A 5 THR 6   2  ALA 6   7 -1  O  ILE 6   3   N  GLY 6 130           
SHEET    3  6A 5 ALA 6  12  ASP 6  17 -1  O  VAL 6  13   N  ILE 6   6           
SHEET    4  6A 5 GLY 6 192  THR 6 199 -1  O  GLU 6 194   N  GLY 6  16           
SHEET    5  6A 5 GLY 6 202  GLU 6 209 -1  O  GLY 6 202   N  THR 6 199           
SHEET    1  6B 2 ASN 6  20  THR 6  22  0                                        
SHEET    2  6B 2 SER 6  25  SER 6  28 -1  O  SER 6  25   N  THR 6  22           
SHEET    1  6C 5 PHE 6  35  GLY 6  38  0                                        
SHEET    2  6C 5 ILE 6  41  GLY 6  47 -1  O  ILE 6  41   N  CYS 6  37           
SHEET    3  6C 5 VAL 6  98  LEU 6 105 -1  O  HIS 6  99   N  ASN 6  46           
SHEET    4  6C 5 GLY 6 111  ASP 6 117 -1  O  ALA 6 112   N  GLY 6 104           
SHEET    5  6C 5 GLY 6 120  GLU 6 125 -1  O  GLY 6 120   N  ASP 6 117           
SHEET    1  7A 5 THR 7 133  ALA 7 135  0                                        
SHEET    2  7A 5 VAL 7   3  TYR 7   8 -1  O  SER 7   5   N  LEU 7 134           
SHEET    3  7A 5 GLY 7  11  ASP 7  17 -1  O  GLY 7  11   N  TYR 7   8           
SHEET    4  7A 5 ASN 7 186  ASP 7 193 -1  O  SER 7 188   N  ALA 7  16           
SHEET    5  7A 5 LEU 7 198  GLN 7 205 -1  O  THR 7 199   N  ILE 7 191           
SHEET    1  7B 2 LEU 7  19  TYR 7  22  0                                        
SHEET    2  7B 2 LEU 7  25  ASN 7  29 -1  O  LEU 7  25   N  TYR 7  22           
SHEET    1  7C 5 LEU 7  34  PRO 7  36  0                                        
SHEET    2  7C 5 THR 7  41  GLY 7  47 -1  O  VAL 7  43   N  ILE 7  35           
SHEET    3  7C 5 ASN 7 104  VAL 7 111 -1  O  ALA 7 105   N  SER 7  46           
SHEET    4  7C 5 GLN 7 117  VAL 7 122 -1  O  PHE 7 118   N  GLY 7 110           
SHEET    5  7C 5 THR 7 128  TYR 7 129 -1  O  TYR 7 129   N  TYR 7 121           
SHEET    1  AA 5 THR A 169  THR A 171  0                                        
SHEET    2  AA 5 SER A  42  ARG A  46 -1  O  SER A  42   N  THR A 171           
SHEET    3  AA 5 THR A  51  GLN A  56 -1  O  VAL A  52   N  VAL A  45           
SHEET    4  AA 5 LEU A 223  THR A 229 -1  O  GLU A 224   N  SER A  55           
SHEET    5  AA 5 LYS A 232  THR A 235 -1  O  LYS A 232   N  THR A 229           
SHEET    1  AB 5 ILE A  72  PHE A  73  0                                        
SHEET    2  AB 5 GLY A  80  ASN A  84 -1  O  MET A  81   N  PHE A  73           
SHEET    3  AB 5 ILE A 140  ASP A 147 -1  O  ILE A 140   N  ASN A  84           
SHEET    4  AB 5 GLY A 151  THR A 157 -1  O  GLY A 151   N  ASP A 147           
SHEET    5  AB 5 TYR A 163  TYR A 166 -1  O  VAL A 164   N  LYS A 156           
SHEET    1  BA 5 ALA B 161  ILE B 164  0                                        
SHEET    2  BA 5 SER B  34  LYS B  38 -1  O  SER B  34   N  ILE B 164           
SHEET    3  BA 5 VAL B  43  GLU B  48 -1  O  VAL B  44   N  ILE B  37           
SHEET    4  BA 5 ILE B 209  ILE B 214 -1  O  GLU B 210   N  THR B  47           
SHEET    5  BA 5 PHE B 235  LYS B 237 -1  O  ARG B 236   N  ILE B 213           
SHEET    1  BB 5 SER B  65  THR B  68  0                                        
SHEET    2  BB 5 ILE B  71  GLY B  77 -1  O  ILE B  71   N  LEU B  67           
SHEET    3  BB 5 VAL B 132  ASP B 140 -1  O  SER B 133   N  SER B  76           
SHEET    4  BB 5 GLY B 144  VAL B 150 -1  O  GLY B 144   N  ASP B 140           
SHEET    5  BB 5 TYR B 156  TRP B 159 -1  O  PHE B 157   N  GLN B 149           
SHEET    1  CA 5 ALA C 162  VAL C 165  0                                        
SHEET    2  CA 5 THR C  34  MET C  39 -1  O  ALA C  35   N  VAL C 165           
SHEET    3  CA 5 GLY C  43  GLU C  49 -1  O  VAL C  45   N  ILE C  38           
SHEET    4  CA 5 LEU C 211  ARG C 217 -1  O  GLU C 212   N  ALA C  48           
SHEET    5  CA 5 TYR C 226  ILE C 229 -1  O  TYR C 226   N  ARG C 217           
SHEET    1  CB 5 LEU C  66  LYS C  68  0                                        
SHEET    2  CB 5 ALA C  74  ALA C  78 -1  O  VAL C  75   N  TYR C  67           
SHEET    3  CB 5 SER C 134  TYR C 140 -1  O  SER C 134   N  ALA C  78           
SHEET    4  CB 5 TYR C 146  SER C 151 -1  O  GLN C 147   N  GLY C 139           
SHEET    5  CB 5 TYR C 157  TRP C 160 -1  O  THR C 158   N  THR C 150           
SHEET    1  DA 5 GLN D 162  ILE D 164  0                                        
SHEET    2  DA 5 ALA D  33  LYS D  37 -1  O  ALA D  33   N  ILE D 164           
SHEET    3  DA 5 VAL D  42  GLU D  47 -1  O  VAL D  43   N  VAL D  36           
SHEET    4  DA 5 ILE D 210  LYS D 216 -1  O  GLU D 211   N  CYS D  46           
SHEET    5  DA 5 ASP D 220  LEU D 224 -1  O  ASP D 220   N  LYS D 216           
SHEET    1  DB 5 SER D  65  ASP D  68  0                                        
SHEET    2  DB 5 VAL D  71  GLY D  77 -1  O  VAL D  71   N  ASP D  68           
SHEET    3  DB 5 VAL D 131  GLY D 137 -1  O  SER D 132   N  SER D  76           
SHEET    4  DB 5 LYS D 146  THR D 150 -1  O  LYS D 146   N  GLY D 137           
SHEET    5  DB 5 TYR D 156  SER D 158 -1  O  SER D 157   N  GLN D 149           
SHEET    1  EA 5 ALA E 169  ILE E 172  0                                        
SHEET    2  EA 5 ALA E  37  ALA E  41 -1  O  ALA E  37   N  ILE E 172           
SHEET    3  EA 5 VAL E  46  GLU E  51 -1  O  VAL E  47   N  ILE E  40           
SHEET    4  EA 5 ALA E 217  THR E 223 -1  O  GLN E 218   N  VAL E  50           
SHEET    5  EA 5 GLY E 227  ILE E 230 -1  O  GLY E 227   N  THR E 223           
SHEET    1  EB 6 ILE E  67  ASP E  71  0                                        
SHEET    2  EB 6 ILE E  74  GLY E  80 -1  O  ILE E  74   N  ILE E  70           
SHEET    3  EB 6 VAL E 140  ASP E 148 -1  O  ALA E 141   N  SER E  79           
SHEET    4  EB 6 GLY E 152  ALA E 158 -1  O  GLY E 152   N  ASP E 148           
SHEET    5  EB 6 PHE E 164  TYR E 167 -1  O  TYR E 165   N  HIS E 157           
SHEET    6  EB 6 SER F  57  SER F  58 -1  O  SER F  58   N  ARG E 166           
SHEET    1  FA 5 GLY F 158  ILE F 161  0                                        
SHEET    2  FA 5 THR F  35  ARG F  39 -1  O  THR F  35   N  ILE F 161           
SHEET    3  FA 5 HIS F  43  LEU F  49 -1  O  VAL F  45   N  LEU F  38           
SHEET    4  FA 5 LEU F 211  GLY F 217 -1  O  SER F 212   N  ALA F  48           
SHEET    5  FA 5 THR F 220  ASP F 226 -1  O  THR F 220   N  GLY F 217           
SHEET    1  FB 5 ILE F  63  ASP F  67  0                                        
SHEET    2  FB 5 MET F  70  GLY F  76 -1  O  MET F  70   N  ASP F  67           
SHEET    3  FB 5 VAL F 130  ASP F 138 -1  O  GLY F 131   N  ALA F  75           
SHEET    4  FB 5 GLY F 141  PHE F 147 -1  O  GLY F 141   N  ASP F 138           
SHEET    5  FB 5 VAL F 153  GLU F 155 -1  O  THR F 154   N  GLU F 146           
SHEET    1  GA 5 GLY G 161  THR G 164  0                                        
SHEET    2  GA 5 SER G  36  LYS G  40 -1  O  SER G  36   N  THR G 164           
SHEET    3  GA 5 GLY G  44  ILE G  53 -1  O  VAL G  46   N  ILE G  39           
SHEET    4  GA 5 ASP G 210  SER G 219 -1  O  ASP G 210   N  ILE G  53           
SHEET    5  GA 5 HIS G 227  VAL G 230 -1  O  LYS G 228   N  TRP G 217           
SHEET    1  GB 5 GLN G  67  VAL G  69  0                                        
SHEET    2  GB 5 ILE G  73  GLY G  79 -1  O  ILE G  73   N  VAL G  69           
SHEET    3  GB 5 VAL G 133  ASP G 141 -1  O  SER G 134   N  SER G  78           
SHEET    4  GB 5 GLY G 144  LEU G 150 -1  O  GLY G 144   N  ASP G 141           
SHEET    5  GB 5 TYR G 156  GLY G 158 -1  O  TRP G 157   N  MET G 149           
SHEET    1  HA 2 ASN H 148  LEU H 149  0                                        
SHEET    2  HA 2 LYS H 154  PHE H 155 -1  O  PHE H 155   N  ASN H 148           
SHEET    1  HB 1 ALA H 100  LYS H 104  0                                        
SHEET    2  HB 1 VAL H 146  LEU H 149  0                                        
SHEET    3  HB 1 LYS H 154  VAL H 157  0                                        
SHEET    4  HB 1 ARG H 173  VAL H 174  0                                        
SHEET    5  HB 1 THR H 199  GLU H 202  0                                        
SHEET    6  HB 1 THR H 270  ILE H 275 -1  O  PHE H 271   N  GLU H 201           
SHEET    7  HB 1 CYS H 304  ASP H 309  1  O  ILE H 305   N  ILE H 272           
SHEET    8  HB 1 ILE H 349  ALA H 354  1  O  LYS H 350   N  ILE H 306           
SHEET    9  HB 1 GLY H 245  LEU H 248  1  O  ILE H 246   N  PHE H 353           
SHEET   10  HB 1 ARG H 373  VAL H 375  1  O  ARG H 373   N  LEU H 247           
SHEET    1  IA 5 ASP I 127  VAL I 130  0                                        
SHEET    2  IA 5 ALA I 118  THR I 121 -1  O  ALA I 118   N  VAL I 130           
SHEET    3  IA 5 LEU I 104  ILE I 112 -1  O  THR I 108   N  THR I 121           
SHEET    4  IA 5 SER I 146  LEU I 149 -1  O  VAL I 147   N  GLY I 107           
SHEET    5  IA 5 ILE I 156  VAL I 159 -1  N  VAL I 157   O  LEU I 148           
SHEET    1  IB 8 ASP I 127  VAL I 130  0                                        
SHEET    2  IB 8 ALA I 118  THR I 121 -1  O  ALA I 118   N  VAL I 130           
SHEET    3  IB 8 LEU I 104  ILE I 112 -1  O  THR I 108   N  THR I 121           
SHEET    4  IB 8 LYS J  93  ASP J  97 -1  O  LYS J  93   N  ILE I 106           
SHEET    5  IB 8 LYS J  83  VAL J  88 -1  O  VAL J  84   N  VAL J  96           
SHEET    6  IB 8 SER J  70  ILE J  78 -1  O  GLU J  74   N  LYS J  87           
SHEET    7  IB 8 GLN J 111  ARG J 116 -1  O  GLN J 111   N  VAL J  75           
SHEET    8  IB 8 LEU J 122  ASN J 128 -1  N  HIS J 123   O  CYS J 114           
SHEET    1  IC 5 LYS I 172  ASP I 174  0                                        
SHEET    2  IC 5 THR I 243  VAL I 248 -1  O  PHE I 244   N  ASP I 174           
SHEET    3  IC 5 SER I 277  ASP I 282  1  O  ILE I 278   N  LEU I 245           
SHEET    4  IC 5 LYS I 323  THR I 328  1  O  LYS I 323   N  VAL I 279           
SHEET    5  IC 5 GLY I 218  TYR I 222  1  O  VAL I 219   N  MET I 326           
SHEET    1  JA 6 MET J 137  GLU J 140  0                                        
SHEET    2  JA 6 LYS J 209  SER J 214 -1  O  PHE J 210   N  GLU J 140           
SHEET    3  JA 6 SER J 243  ASP J 248  1  O  ILE J 244   N  ILE J 211           
SHEET    4  JA 6 ILE J 288  ALA J 293  1  O  LYS J 289   N  ILE J 245           
SHEET    5  JA 6 GLY J 184  TYR J 188  1  O  VAL J 185   N  MET J 292           
SHEET    6  JA 6 ARG J 312  GLU J 315  1  O  ARG J 312   N  ILE J 186           
SHEET    1  KA 5 SER K 117  ARG K 121  0                                        
SHEET    2  KA 5 THR K 107  SER K 112 -1  O  GLY K 108   N  VAL K 120           
SHEET    3  KA 5 LEU K  94  ASP K 104 -1  O  GLN K  98   N  SER K 111           
SHEET    4  KA 5 MET K 135  LEU K 139 -1  O  MET K 135   N  PHE K  99           
SHEET    5  KA 5 LEU K 146  LEU K 150 -1  N  VAL K 147   O  ALA K 138           
SHEET    1  KB 8 SER K 117  ARG K 121  0                                        
SHEET    2  KB 8 THR K 107  SER K 112 -1  O  GLY K 108   N  VAL K 120           
SHEET    3  KB 8 LEU K  94  ASP K 104 -1  O  GLN K  98   N  SER K 111           
SHEET    4  KB 8 ARG L 126  VAL L 129 -1  O  ARG L 126   N  ILE K  96           
SHEET    5  KB 8 TYR L 117  ALA L 121 -1  O  TYR L 117   N  VAL L 129           
SHEET    6  KB 8 GLN L 103  GLU L 111 -1  O  GLU L 107   N  LYS L 120           
SHEET    7  KB 8 ARG L 145  LEU L 148  1  O  VAL L 146   N  GLY L 106           
SHEET    8  KB 8 ILE L 155  ILE L 158  1  N  MET L 156   O  THR L 147           
SHEET    1  KC 8 SER K 117  ARG K 121  0                                        
SHEET    2  KC 8 THR K 107  SER K 112 -1  O  GLY K 108   N  VAL K 120           
SHEET    3  KC 8 LEU K  94  ASP K 104 -1  O  GLN K  98   N  SER K 111           
SHEET    4  KC 8 ARG L 126  VAL L 129 -1  O  ARG L 126   N  ILE K  96           
SHEET    5  KC 8 TYR L 117  ALA L 121 -1  O  TYR L 117   N  VAL L 129           
SHEET    6  KC 8 GLN L 103  GLU L 111 -1  O  GLU L 107   N  LYS L 120           
SHEET    7  KC 8 THR M 126  PRO M 130 -1  O  THR M 126   N  ILE L 105           
SHEET    8  KC 8 ALA M 116  LYS M 120 -1  O  ALA M 117   N  LEU M 129           
SHEET    1  KD 6 GLY K 162  GLU K 165  0                                        
SHEET    2  KD 6 ALA K 233  ASN K 238 -1  O  PHE K 234   N  ASN K 164           
SHEET    3  KD 6 SER K 267  ASP K 272  1  O  ILE K 268   N  ILE K 235           
SHEET    4  KD 6 VAL K 312  MET K 316  1  O  LYS K 313   N  ILE K 269           
SHEET    5  KD 6 GLY K 208  TYR K 212  1  O  VAL K 209   N  MET K 316           
SHEET    6  KD 6 LEU K 334  GLU K 339  1  O  ARG K 336   N  LEU K 210           
SHEET    1  LA 6 THR L 171  GLU L 174  0                                        
SHEET    2  LA 6 ASN L 242  PRO L 247 -1  O  PHE L 243   N  PHE L 173           
SHEET    3  LA 6 CYS L 276  ASP L 281  1  O  ILE L 277   N  ILE L 244           
SHEET    4  LA 6 THR L 321  THR L 327  1  O  LYS L 322   N  ILE L 278           
SHEET    5  LA 6 GLY L 217  TYR L 221  1  O  VAL L 218   N  MET L 325           
SHEET    6  LA 6 ARG L 345  GLU L 348  1  O  ARG L 345   N  LEU L 219           
SHEET    1  MA 3 LEU M  78  VAL M  82  0                                        
SHEET    2  MA 3 ASP M 144  VAL M 148 -1  O  ASP M 144   N  VAL M  82           
SHEET    3  MA 3 ILE M 155  THR M 158 -1  N  LEU M 156   O  GLY M 147           
SHEET    1  MB 4 MET M 170  GLU M 174  0                                        
SHEET    2  MB 4 THR M 242  ALA M 247 -1  O  PHE M 243   N  ASP M 173           
SHEET    3  MB 4 THR M 276  ASP M 281  1  O  ILE M 277   N  LEU M 244           
SHEET    4  MB 4 VAL M 321  ALA M 325  1  O  LYS M 322   N  ILE M 278           
SHEET    1  MC 2 GLY M 217  MET M 220  0                                        
SHEET    2  MC 2 LEU M 343  ILE M 347  1  O  ARG M 345   N  LEU M 219           
SHEET    1  NA 2 VAL N 713  ILE N 715  0                                        
SHEET    2  NA 2 PHE N 753  PRO N 755 -1  O  THR N 754   N  THR N 714           
SHEET    1  NB 3 GLY N 760  ILE N 761  0                                        
SHEET    2  NB 3 VAL N 903  ASP N 907  1  O  VAL N 903   N  ILE N 761           
SHEET    3  NB 3 PHE N 890  PRO N 892 -1  O  VAL N 891   N  ARG N 906           
SHEET    1  NC 2 GLN N 772  CYS N 775  0                                        
SHEET    2  NC 2 TYR N 866  ASP N 869 -1  O  TYR N 866   N  CYS N 775           
SHEET    1  OA 2 LEU O 308  SER O 309  0                                        
SHEET    2  OA 2 LEU O 347  VAL O 348 -1  O  VAL O 348   N  LEU O 308           
SHEET    1  OB 4 ILE O 341  GLN O 343  0                                        
SHEET    2  OB 4 TYR P 357  THR P 361  1  N  SER P 358   O  ILE O 341           
SHEET    3  OB 4 ILE P 399  ASN P 401 -1  O  VAL P 400   N  ILE P 360           
SHEET    4  OB 4 LYS P 392  ASN P 394 -1  O  LYS P 392   N  ASN P 401           
SHEET    1  QA 3 CYS Q 356  GLU Q 358  0                                        
SHEET    2  QA 3 TRP Q 396  VAL Q 399 -1  O  LEU Q 397   N  VAL Q 357           
SHEET    3  QA 3 GLY Q 388  LEU Q 390 -1  O  VAL Q 389   N  TYR Q 398           
SHEET    1  RA 3 LEU R 348  SER R 349  0                                        
SHEET    2  RA 3 ILE R 387  GLU R 389 -1  O  VAL R 388   N  LEU R 348           
SHEET    3  RA 3 VAL R 380  ASP R 382 -1  O  VAL R 380   N  GLU R 389           
SHEET    1  SA 3 LYS S 401  ILE S 402  0                                        
SHEET    2  SA 3 PHE S 442  GLU S 444 -1  O  ILE S 443   N  ILE S 402           
SHEET    3  SA 3 LYS S 435  ASN S 437 -1  O  LYS S 435   N  GLU S 444           
SHEET    1  TA 3 LEU T 200  PRO T 201  0                                        
SHEET    2  TA 3 LYS T 232  VAL T 233 -1  O  VAL T 233   N  LEU T 200           
SHEET    3  TA 3 ILE T 228  VAL T 229 -1  O  VAL T 229   N  LYS T 232           
SHEET    1  UA 6 VAL U   8  ILE U  10  0                                        
SHEET    2  UA 6 ILE U  46  LEU U  54  1  O  ILE U  46   N  THR U   9           
SHEET    3  UA 6 VAL U  34  ASP U  40 -1  O  VAL U  34   N  LEU U  54           
SHEET    4  UA 6 LYS U  88  HIS U  94 -1  O  LYS U  88   N  GLY U  39           
SHEET    5  UA 6 LEU U 119  VAL U 123  1  O  LEU U 119   N  TRP U  92           
SHEET    6  UA 6 THR U 134  VAL U 138 -1  O  ASP U 135   N  ILE U 122           
SHEET    1  UB 2 PHE U  56  GLU U  58  0                                        
SHEET    2  UB 2 TRP U  66  LEU U  68 -1  O  PHE U  67   N  GLU U  57           
SHEET    1  VA 3 VAL V  63  VAL V  65  0                                        
SHEET    2  VA 3 VAL V  27  ILE V  29  1  O  TYR V  28   N  VAL V  65           
SHEET    3  VA 3 ILE V 201  TYR V 203  1  O  ASP V 202   N  ILE V  29           
SHEET    1  VB 6 ASP V  67  ALA V  70  0                                        
SHEET    2  VB 6 MET V  50  GLY V  55 -1  O  LEU V  52   N  PHE V  69           
SHEET    3  VB 6 MET V 103  HIS V 109 -1  O  MET V 103   N  GLY V  55           
SHEET    4  VB 6 VAL V 137  ASP V 142  1  O  VAL V 137   N  TRP V 107           
SHEET    5  VB 6 VAL V 152  LEU V 158 -1  O  VAL V 152   N  ASP V 142           
SHEET    6  VB 6 TYR V 196  SER V 198 -1  O  TYR V 197   N  ARG V 157           
SHEET    1  WA 4 ARG W  60  THR W  66  0                                        
SHEET    2  WA 4 VAL W  49  SER W  53 -1  O  VAL W  49   N  THR W  66           
SHEET    3  WA 4 THR W   6  ILE W  10  1  O  THR W   6   N  GLY W  50           
SHEET    4  WA 4 ILE W 110  ALA W 112  1  O  VAL W 111   N  VAL W   9           
SHEET    1  WB 2 ASP W 140  ILE W 141  0                                        
SHEET    2  WB 2 HIS W 170  LEU W 171  1  O  HIS W 170   N  ILE W 141           
SHEET    1  XA 4 ILE X   8  PHE X  10  0                                        
SHEET    2  XA 4 GLU X  32  ILE X  35 -1  O  ILE X  33   N  PHE X  10           
SHEET    3  XA 4 PHE X  48  ARG X  51 -1  O  GLU X  49   N  GLU X  34           
SHEET    4  XA 4 SER X  65  LEU X  66 -1  O  LEU X  66   N  PHE X  48           
SHEET    1  XB 4 GLY X  13  CYS X  15  0                                        
SHEET    2  XB 4 TYR X  97  TRP X 100 -1  O  PHE X  98   N  CYS X  15           
SHEET    3  XB 4 ALA X  88  VAL X  90 -1  O  LEU X  89   N  TYR X  97           
SHEET    4  XB 4 MET X  74  VAL X  76 -1  O  MET X  74   N  VAL X  90           
SHEET    1  ZA 2 MET Z 862  MET Z 864  0                                        
SHEET    2  ZA 2 ILE Z 908  PRO Z 910 -1  O  ARG Z 909   N  THR Z 863           
SHEET    1  ZB 3 ALA Z 915  LEU Z 916  0                                        
SHEET    2  ZB 3 VAL Z 981  LYS Z 984  1  O  VAL Z 981   N  LEU Z 916           
SHEET    3  ZB 3 ILE Z 971  SER Z 972 -1  O  ILE Z 971   N  LYS Z 984           
CISPEP   1 SER H  164    PRO H  165          0        18.43                     
CISPEP   2 ASN I  102    PRO I  103          0        12.60                     
CISPEP   3 ALA I  275    PRO I  276          0         9.15                     
CISPEP   4 ALA J  241    PRO J  242          0         8.79                     
CISPEP   5 VAL K   92    PRO K   93          0        -6.26                     
CISPEP   6 ALA K  265    PRO K  266          0         0.89                     
CISPEP   7 GLU L  274    PRO L  275          0       -15.95                     
CISPEP   8 LEU M   75    PRO M   76          0        -8.74                     
CISPEP   9 ALA M  274    PRO M  275          0       -14.58                     
CISPEP  10 GLY U   96    PRO U   97          0        -4.27                     
CISPEP  11 PRO W   22    ARG W   23          0        10.24                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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