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Database: PDB
Entry: 4GZA
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Original site: 4GZA 
HEADER    SIGNALING PROTEIN                       06-SEP-12   4GZA              
TITLE     COMPLEX OF MOUSE PLEXIN A2 - SEMAPHORIN 3A - NEUROPILIN-1             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PLEXIN-A2;                                                 
COMPND   3 CHAIN: A, B, C, D, E, F;                                             
COMPND   4 FRAGMENT: UNP RESIDUES 33-703;                                       
COMPND   5 SYNONYM: PLEX 2, PLEXIN-2;                                           
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: SEMAPHORIN-3A;                                             
COMPND   9 CHAIN: G;                                                            
COMPND  10 FRAGMENT: UNP RESIDUES 21-555;                                       
COMPND  11 SYNONYM: SEMAPHORIN III, SEMA III, SEMAPHORIN-D, SEMA D;             
COMPND  12 ENGINEERED: YES;                                                     
COMPND  13 MOL_ID: 3;                                                           
COMPND  14 MOLECULE: NEUROPILIN-1;                                              
COMPND  15 CHAIN: H;                                                            
COMPND  16 FRAGMENT: UNP RESIDUES 22-586;                                       
COMPND  17 SYNONYM: A5 PROTEIN;                                                 
COMPND  18 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE   3 ORGANISM_COMMON: MOUSE;                                              
SOURCE   4 ORGANISM_TAXID: 10090;                                               
SOURCE   5 GENE: PLXNA2, KIAA0463;                                              
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   9 EXPRESSION_SYSTEM_CELL_LINE: HEK293;                                 
SOURCE  10 MOL_ID: 2;                                                           
SOURCE  11 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  12 ORGANISM_COMMON: MOUSE;                                              
SOURCE  13 ORGANISM_TAXID: 10090;                                               
SOURCE  14 GENE: SEMA3A, SEMAD, SEMD;                                           
SOURCE  15 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  16 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  17 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  18 EXPRESSION_SYSTEM_CELL_LINE: HEK293;                                 
SOURCE  19 MOL_ID: 3;                                                           
SOURCE  20 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  21 ORGANISM_COMMON: MOUSE;                                              
SOURCE  22 ORGANISM_TAXID: 10090;                                               
SOURCE  23 GENE: NRP1, NRP;                                                     
SOURCE  24 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  25 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  26 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  27 EXPRESSION_SYSTEM_CELL_LINE: HEK293                                  
KEYWDS    TERNARY COMPLEX, MULTI-DOMAIN, MAMMALIAN, CELL-CELL SIGNALING,        
KEYWDS   2 GLYCOSILATION, TRANSMEMBRANE, SIGNALING PROTEIN                      
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    B.J.C.JANSSEN,T.MALINAUSKAS,C.SIEBOLD,E.Y.JONES                       
REVDAT   3   26-DEC-12 4GZA    1       JRNL                                     
REVDAT   2   07-NOV-12 4GZA    1       JRNL                                     
REVDAT   1   17-OCT-12 4GZA    0                                                
JRNL        AUTH   B.J.C.JANSSEN,T.MALINAUSKAS,G.A.WEIR,M.Z.CADER,C.SIEBOLD,    
JRNL        AUTH 2 E.Y.JONES                                                    
JRNL        TITL   NEUROPILINS LOCK SECRETED SEMAPHORINS ONTO PLEXINS IN A      
JRNL        TITL 2 TERNARY SIGNALING COMPLEX.                                   
JRNL        REF    NAT.STRUCT.MOL.BIOL.          V.  19  1293 2012              
JRNL        REFN                   ISSN 1545-9993                               
JRNL        PMID   23104057                                                     
JRNL        DOI    10.1038/NSMB.2416                                            
REMARK   2                                                                      
REMARK   2 RESOLUTION.    7.00 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.7.3_928)                    
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN             
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-                     
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,              
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL            
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE                  
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM             
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,             
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER                
REMARK   3               : ZWART                                                
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : MLHL                                          
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 7.00                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 125.51                         
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : -3.000                         
REMARK   3   COMPLETENESS FOR RANGE        (%) : 95.6                           
REMARK   3   NUMBER OF REFLECTIONS             : 20176                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.285                           
REMARK   3   R VALUE            (WORKING SET) : 0.285                           
REMARK   3   FREE R VALUE                     : 0.285                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.050                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 1009                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1125.5263 - 16.8594    0.91     2575   141  0.2832 0.2739        
REMARK   3     2 16.8594 - 13.3867    0.88     2455   130  0.2752 0.2800        
REMARK   3     3 13.3867 - 11.6959    0.93     2643   121  0.2530 0.2764        
REMARK   3     4 11.6959 - 10.6272    0.95     2731   127  0.2403 0.2518        
REMARK   3     5 10.6272 -  9.8658    0.95     2667   150  0.2527 0.2287        
REMARK   3     6  9.8658 -  9.2843    0.95     2657   132  0.2596 0.2691        
REMARK   3     7  9.2843 -  8.8195    0.95     2700   139  0.2803 0.2878        
REMARK   3     8  8.8195 -  8.4357    0.85     2394   133  0.2921 0.3188        
REMARK   3     9  8.4357 -  8.1110    0.81     2287   121  0.3213 0.3209        
REMARK   3    10  8.1110 -  7.8311    0.90     2565   134  0.3312 0.3185        
REMARK   3    11  7.8311 -  7.5863    0.93     2583   158  0.3451 0.3061        
REMARK   3    12  7.5863 -  7.3695    0.94     2631   149  0.3447 0.3188        
REMARK   3    13  7.3695 -  7.1755    0.94     2660   168  0.3578 0.3668        
REMARK   3    14  7.1755 -  7.0004    0.94     2608   119  0.3727 0.3619        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.30                                          
REMARK   3   SHRINKAGE RADIUS   : 1.11                                          
REMARK   3   K_SOL              : 0.34                                          
REMARK   3   B_SOL              : 283.54                                        
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 1.030            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 29.140           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : 84.12440                                             
REMARK   3    B22 (A**2) : 17.45580                                             
REMARK   3    B33 (A**2) : 22.67680                                             
REMARK   3    B12 (A**2) : -0.00000                                             
REMARK   3    B13 (A**2) : 119.00390                                            
REMARK   3    B23 (A**2) : -0.00000                                             
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.014          36622                                  
REMARK   3   ANGLE     :  1.202          49584                                  
REMARK   3   CHIRALITY :  0.063           5452                                  
REMARK   3   PLANARITY :  0.008           6434                                  
REMARK   3   DIHEDRAL  : 13.074          13337                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS:                                           
REMARK   3  AUTHORS STATE THAT DUE TO THE LOW RESOLUTION OF THE DIFFRACTION     
REMARK   3  DATA THE STRUCTURE WAS ONLY SUBJECTED TO RIGID BODY REFINEMENT WITH 
REMARK   3  EACH DOMAIN AS RIGID BODY USING (PARTS OF) THE COORDINATES OF PDB   
REMARK   3  ENTRIES 3OKT, 1Q47 AND 4GZ9.                                        
REMARK   3  AUTHORS HAVE NOT FURTHER REFINED THE RESULTING COORDINATES NOR      
REMARK   3  CORRECTED RESULTING CLASHES BETWEEN ATOMS AND DEVIATING PEPTIDE     
REMARK   3  LINKAGES BETWEEN DOMAINS.                                           
REMARK   4                                                                      
REMARK   4 4GZA COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 28-SEP-12.                  
REMARK 100 THE RCSB ID CODE IS RCSB074820.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 15-APR-11; 20-APR-11; 05-MAY-11    
REMARK 200  TEMPERATURE           (KELVIN) : 100; 100; 100                      
REMARK 200  PH                             : 7.5; 7.5; 7.5                      
REMARK 200  NUMBER OF CRYSTALS USED        : 3                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y; Y; Y                            
REMARK 200  RADIATION SOURCE               : DIAMOND; DIAMOND; DIAMOND          
REMARK 200  BEAMLINE                       : I04-1; I03; I02                    
REMARK 200  X-RAY GENERATOR MODEL          : NULL; NULL; NULL                   
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M; M; M                            
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.91730; 1.07190; 0.9795           
REMARK 200  MONOCHROMATOR                  : SINGLE BOUNCE MONOCHROMATOR;       
REMARK 200                                   DOUBLE CRYSTAL MONOCHROMATOR;      
REMARK 200                                   DOUBLE CRYSTAL MONOCHROMATOR       
REMARK 200  OPTICS                         : NULL; NULL; NULL                   
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : PIXEL; PIXEL; AREA DETECTOR        
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 2M; DECTRIS        
REMARK 200                                   PILATUS 6M; ADSC QUANTUM 315R      
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : MOSFLM                             
REMARK 200  DATA SCALING SOFTWARE          : AIMLESS                            
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 20176                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 7.000                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 126.000                            
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 95.6                               
REMARK 200  DATA REDUNDANCY                : NULL                               
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : NULL                               
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : NULL                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH; SINGLE WAVELENGTH; SINGLE   
REMARK 200                       WAVELENGTH                                     
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: 3OKT, 1Q47, 4GZ9                                     
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): NULL                                      
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): NULL                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 70MM HEPES, PH 7.5, 1.4% W/V PEG 400,    
REMARK 280  12% V/V GLYCEROL, 1.4M AMMONIUM SULPHATE, VAPOR DIFFUSION,          
REMARK 280  SITTING DROP, TEMPERATURE 293K. 70MM HEPES, PH 7.5, 1.4% W/V PEG    
REMARK 280  400, 12% V/V GLYCEROL, 1.4M AMMONIUM SULPHATE, 1% V/V ETHYL         
REMARK 280  ACETATE, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293K. 70MM      
REMARK 280  HEPES, PH 7.5, 1.4% W/V PEG 400, 12% V/V GLYCEROL, 1.4M AMMONIUM    
REMARK 280  SULPHATE, 8% V/V ACETONITRILE , VAPOR DIFFUSION, SITTING DROP,      
REMARK 280  TEMPERATURE 293K                                                    
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1                          
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y,-Z                                                 
REMARK 290       3555   X+1/2,Y+1/2,Z                                           
REMARK 290       4555   -X+1/2,Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000       95.81600            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000      146.80200            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000       95.81600            
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000      146.80200            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXADECAMERIC                     
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H                
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350   BIOMT1   2 -1.000000  0.000000  0.000000       71.11529            
REMARK 350   BIOMT2   2  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000     -241.94080            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     GLU A    32                                                      
REMARK 465     THR A    33                                                      
REMARK 465     GLY A    34                                                      
REMARK 465     MET A    35                                                      
REMARK 465     ASP A   264                                                      
REMARK 465     GLY A   265                                                      
REMARK 465     MET A   266                                                      
REMARK 465     ALA A   267                                                      
REMARK 465     ILE A   268                                                      
REMARK 465     ASN A   269                                                      
REMARK 465     SER A   270                                                      
REMARK 465     ALA A   271                                                      
REMARK 465     GLY A   272                                                      
REMARK 465     ASP A   627                                                      
REMARK 465     GLN A   628                                                      
REMARK 465     GLN A   703                                                      
REMARK 465     GLY A   704                                                      
REMARK 465     THR A   705                                                      
REMARK 465     LYS A   706                                                      
REMARK 465     HIS A   707                                                      
REMARK 465     HIS A   708                                                      
REMARK 465     HIS A   709                                                      
REMARK 465     HIS A   710                                                      
REMARK 465     HIS A   711                                                      
REMARK 465     HIS A   712                                                      
REMARK 465     GLU B    32                                                      
REMARK 465     THR B    33                                                      
REMARK 465     GLY B    34                                                      
REMARK 465     MET B    35                                                      
REMARK 465     ASP B   264                                                      
REMARK 465     GLY B   265                                                      
REMARK 465     MET B   266                                                      
REMARK 465     ALA B   267                                                      
REMARK 465     ILE B   268                                                      
REMARK 465     ASN B   269                                                      
REMARK 465     SER B   270                                                      
REMARK 465     ALA B   271                                                      
REMARK 465     GLY B   272                                                      
REMARK 465     ASP B   627                                                      
REMARK 465     GLN B   628                                                      
REMARK 465     GLN B   703                                                      
REMARK 465     GLY B   704                                                      
REMARK 465     THR B   705                                                      
REMARK 465     LYS B   706                                                      
REMARK 465     HIS B   707                                                      
REMARK 465     HIS B   708                                                      
REMARK 465     HIS B   709                                                      
REMARK 465     HIS B   710                                                      
REMARK 465     HIS B   711                                                      
REMARK 465     HIS B   712                                                      
REMARK 465     GLU C    32                                                      
REMARK 465     THR C    33                                                      
REMARK 465     GLY C    34                                                      
REMARK 465     MET C    35                                                      
REMARK 465     ASP C   264                                                      
REMARK 465     GLY C   265                                                      
REMARK 465     MET C   266                                                      
REMARK 465     ALA C   267                                                      
REMARK 465     ILE C   268                                                      
REMARK 465     ASN C   269                                                      
REMARK 465     SER C   270                                                      
REMARK 465     ALA C   271                                                      
REMARK 465     GLY C   272                                                      
REMARK 465     ASP C   627                                                      
REMARK 465     GLN C   628                                                      
REMARK 465     GLN C   703                                                      
REMARK 465     GLY C   704                                                      
REMARK 465     THR C   705                                                      
REMARK 465     LYS C   706                                                      
REMARK 465     HIS C   707                                                      
REMARK 465     HIS C   708                                                      
REMARK 465     HIS C   709                                                      
REMARK 465     HIS C   710                                                      
REMARK 465     HIS C   711                                                      
REMARK 465     HIS C   712                                                      
REMARK 465     GLU D    32                                                      
REMARK 465     THR D    33                                                      
REMARK 465     GLY D    34                                                      
REMARK 465     MET D    35                                                      
REMARK 465     ASP D   264                                                      
REMARK 465     GLY D   265                                                      
REMARK 465     MET D   266                                                      
REMARK 465     ALA D   267                                                      
REMARK 465     ILE D   268                                                      
REMARK 465     ASN D   269                                                      
REMARK 465     SER D   270                                                      
REMARK 465     ALA D   271                                                      
REMARK 465     GLY D   272                                                      
REMARK 465     ASP D   627                                                      
REMARK 465     GLN D   628                                                      
REMARK 465     GLN D   703                                                      
REMARK 465     GLY D   704                                                      
REMARK 465     THR D   705                                                      
REMARK 465     LYS D   706                                                      
REMARK 465     HIS D   707                                                      
REMARK 465     HIS D   708                                                      
REMARK 465     HIS D   709                                                      
REMARK 465     HIS D   710                                                      
REMARK 465     HIS D   711                                                      
REMARK 465     HIS D   712                                                      
REMARK 465     GLU E    32                                                      
REMARK 465     THR E    33                                                      
REMARK 465     GLY E    34                                                      
REMARK 465     MET E    35                                                      
REMARK 465     ASP E   264                                                      
REMARK 465     GLY E   265                                                      
REMARK 465     MET E   266                                                      
REMARK 465     ALA E   267                                                      
REMARK 465     ILE E   268                                                      
REMARK 465     ASN E   269                                                      
REMARK 465     SER E   270                                                      
REMARK 465     ALA E   271                                                      
REMARK 465     GLY E   272                                                      
REMARK 465     ASP E   627                                                      
REMARK 465     GLN E   628                                                      
REMARK 465     GLN E   703                                                      
REMARK 465     GLY E   704                                                      
REMARK 465     THR E   705                                                      
REMARK 465     LYS E   706                                                      
REMARK 465     HIS E   707                                                      
REMARK 465     HIS E   708                                                      
REMARK 465     HIS E   709                                                      
REMARK 465     HIS E   710                                                      
REMARK 465     HIS E   711                                                      
REMARK 465     HIS E   712                                                      
REMARK 465     GLU F    32                                                      
REMARK 465     THR F    33                                                      
REMARK 465     GLY F    34                                                      
REMARK 465     MET F    35                                                      
REMARK 465     ASP F   264                                                      
REMARK 465     GLY F   265                                                      
REMARK 465     MET F   266                                                      
REMARK 465     ALA F   267                                                      
REMARK 465     ILE F   268                                                      
REMARK 465     ASN F   269                                                      
REMARK 465     SER F   270                                                      
REMARK 465     ALA F   271                                                      
REMARK 465     GLY F   272                                                      
REMARK 465     ASP F   627                                                      
REMARK 465     GLN F   628                                                      
REMARK 465     GLN F   703                                                      
REMARK 465     GLY F   704                                                      
REMARK 465     THR F   705                                                      
REMARK 465     LYS F   706                                                      
REMARK 465     HIS F   707                                                      
REMARK 465     HIS F   708                                                      
REMARK 465     HIS F   709                                                      
REMARK 465     HIS F   710                                                      
REMARK 465     HIS F   711                                                      
REMARK 465     HIS F   712                                                      
REMARK 465     GLU G    18                                                      
REMARK 465     THR G    19                                                      
REMARK 465     GLY G    20                                                      
REMARK 465     ASN G    21                                                      
REMARK 465     TYR G    22                                                      
REMARK 465     ALA G    23                                                      
REMARK 465     ASN G    24                                                      
REMARK 465     GLY G    25                                                      
REMARK 465     PRO G   465                                                      
REMARK 465     LYS G   466                                                      
REMARK 465     GLU G   467                                                      
REMARK 465     THR G   468                                                      
REMARK 465     TRP G   469                                                      
REMARK 465     HIS G   470                                                      
REMARK 465     ASP G   471                                                      
REMARK 465     LEU G   472                                                      
REMARK 465     GLU G   473                                                      
REMARK 465     GLU G   474                                                      
REMARK 465     VAL G   475                                                      
REMARK 465     GLY G   521                                                      
REMARK 465     LYS G   522                                                      
REMARK 465     ALA G   523                                                      
REMARK 465     CYS G   524                                                      
REMARK 465     ALA G   525                                                      
REMARK 465     GLU G   526                                                      
REMARK 465     CYS G   527                                                      
REMARK 465     CYS G   528                                                      
REMARK 465     LEU G   529                                                      
REMARK 465     ALA G   530                                                      
REMARK 465     ARG G   531                                                      
REMARK 465     ASP G   532                                                      
REMARK 465     PRO G   533                                                      
REMARK 465     TYR G   534                                                      
REMARK 465     CYS G   535                                                      
REMARK 465     ALA G   536                                                      
REMARK 465     TRP G   537                                                      
REMARK 465     ASP G   538                                                      
REMARK 465     GLY G   539                                                      
REMARK 465     SER G   540                                                      
REMARK 465     SER G   541                                                      
REMARK 465     CYS G   542                                                      
REMARK 465     SER G   543                                                      
REMARK 465     ARG G   544                                                      
REMARK 465     TYR G   545                                                      
REMARK 465     PHE G   546                                                      
REMARK 465     PRO G   547                                                      
REMARK 465     THR G   548                                                      
REMARK 465     ALA G   549                                                      
REMARK 465     LYS G   550                                                      
REMARK 465     ARG G   551                                                      
REMARK 465     ARG G   552                                                      
REMARK 465     THR G   553                                                      
REMARK 465     ARG G   554                                                      
REMARK 465     ARG G   555                                                      
REMARK 465     GLU H    19                                                      
REMARK 465     THR H    20                                                      
REMARK 465     GLY H    21                                                      
REMARK 465     PHE H    22                                                      
REMARK 465     ARG H    23                                                      
REMARK 465     SER H    24                                                      
REMARK 465     LYS H   142                                                      
REMARK 465     ARG H   143                                                      
REMARK 465     GLY H   144                                                      
REMARK 465     PRO H   145                                                      
REMARK 465     GLU H   146                                                      
REMARK 465     CYS H   147                                                      
REMARK 465     SER H   148                                                      
REMARK 465     GLN H   149                                                      
REMARK 465     ASN H   150                                                      
REMARK 465     TYR H   151                                                      
REMARK 465     THR H   152                                                      
REMARK 465     ALA H   153                                                      
REMARK 465     PRO H   154                                                      
REMARK 465     THR H   155                                                      
REMARK 465     GLY H   156                                                      
REMARK 465     VAL H   157                                                      
REMARK 465     ILE H   158                                                      
REMARK 465     LYS H   159                                                      
REMARK 465     SER H   160                                                      
REMARK 465     PRO H   161                                                      
REMARK 465     GLY H   162                                                      
REMARK 465     PHE H   163                                                      
REMARK 465     PRO H   164                                                      
REMARK 465     GLU H   165                                                      
REMARK 465     LYS H   166                                                      
REMARK 465     TYR H   167                                                      
REMARK 465     PRO H   168                                                      
REMARK 465     ASN H   169                                                      
REMARK 465     SER H   170                                                      
REMARK 465     LEU H   171                                                      
REMARK 465     GLU H   172                                                      
REMARK 465     CYS H   173                                                      
REMARK 465     THR H   174                                                      
REMARK 465     TYR H   175                                                      
REMARK 465     ILE H   176                                                      
REMARK 465     ILE H   177                                                      
REMARK 465     PHE H   178                                                      
REMARK 465     ALA H   179                                                      
REMARK 465     PRO H   180                                                      
REMARK 465     LYS H   181                                                      
REMARK 465     MET H   182                                                      
REMARK 465     SER H   183                                                      
REMARK 465     GLU H   184                                                      
REMARK 465     ILE H   185                                                      
REMARK 465     ILE H   186                                                      
REMARK 465     LEU H   187                                                      
REMARK 465     GLU H   188                                                      
REMARK 465     PHE H   189                                                      
REMARK 465     GLU H   190                                                      
REMARK 465     SER H   191                                                      
REMARK 465     PHE H   192                                                      
REMARK 465     ASP H   193                                                      
REMARK 465     LEU H   194                                                      
REMARK 465     GLU H   195                                                      
REMARK 465     GLN H   196                                                      
REMARK 465     ASP H   197                                                      
REMARK 465     SER H   198                                                      
REMARK 465     ASN H   199                                                      
REMARK 465     PRO H   200                                                      
REMARK 465     PRO H   201                                                      
REMARK 465     GLY H   202                                                      
REMARK 465     GLY H   203                                                      
REMARK 465     MET H   204                                                      
REMARK 465     PHE H   205                                                      
REMARK 465     CYS H   206                                                      
REMARK 465     ARG H   207                                                      
REMARK 465     TYR H   208                                                      
REMARK 465     ASP H   209                                                      
REMARK 465     ARG H   210                                                      
REMARK 465     LEU H   211                                                      
REMARK 465     GLU H   212                                                      
REMARK 465     ILE H   213                                                      
REMARK 465     TRP H   214                                                      
REMARK 465     ASP H   215                                                      
REMARK 465     GLY H   216                                                      
REMARK 465     PHE H   217                                                      
REMARK 465     PRO H   218                                                      
REMARK 465     GLU H   219                                                      
REMARK 465     VAL H   220                                                      
REMARK 465     GLY H   221                                                      
REMARK 465     PRO H   222                                                      
REMARK 465     HIS H   223                                                      
REMARK 465     ILE H   224                                                      
REMARK 465     GLY H   225                                                      
REMARK 465     ARG H   226                                                      
REMARK 465     TYR H   227                                                      
REMARK 465     CYS H   228                                                      
REMARK 465     GLY H   229                                                      
REMARK 465     GLN H   230                                                      
REMARK 465     LYS H   231                                                      
REMARK 465     THR H   232                                                      
REMARK 465     PRO H   233                                                      
REMARK 465     GLY H   234                                                      
REMARK 465     ARG H   235                                                      
REMARK 465     ILE H   236                                                      
REMARK 465     ARG H   237                                                      
REMARK 465     SER H   238                                                      
REMARK 465     SER H   239                                                      
REMARK 465     SER H   240                                                      
REMARK 465     GLY H   241                                                      
REMARK 465     VAL H   242                                                      
REMARK 465     LEU H   243                                                      
REMARK 465     SER H   244                                                      
REMARK 465     MET H   245                                                      
REMARK 465     VAL H   246                                                      
REMARK 465     PHE H   247                                                      
REMARK 465     TYR H   248                                                      
REMARK 465     THR H   249                                                      
REMARK 465     ASP H   250                                                      
REMARK 465     SER H   251                                                      
REMARK 465     ALA H   252                                                      
REMARK 465     ILE H   253                                                      
REMARK 465     ALA H   254                                                      
REMARK 465     LYS H   255                                                      
REMARK 465     GLU H   256                                                      
REMARK 465     GLY H   257                                                      
REMARK 465     PHE H   258                                                      
REMARK 465     SER H   259                                                      
REMARK 465     ALA H   260                                                      
REMARK 465     ASN H   261                                                      
REMARK 465     TYR H   262                                                      
REMARK 465     SER H   263                                                      
REMARK 465     VAL H   264                                                      
REMARK 465     LEU H   265                                                      
REMARK 465     GLN H   266                                                      
REMARK 465     SER H   267                                                      
REMARK 465     SER H   268                                                      
REMARK 465     ILE H   269                                                      
REMARK 465     SER H   270                                                      
REMARK 465     GLU H   271                                                      
REMARK 465     ASP H   272                                                      
REMARK 465     PHE H   273                                                      
REMARK 465     LYS H   274                                                      
REMARK 465     CYS H   275                                                      
REMARK 465     MET H   276                                                      
REMARK 465     GLU H   277                                                      
REMARK 465     ALA H   278                                                      
REMARK 465     LEU H   279                                                      
REMARK 465     GLY H   280                                                      
REMARK 465     MET H   281                                                      
REMARK 465     GLU H   282                                                      
REMARK 465     SER H   283                                                      
REMARK 465     GLY H   284                                                      
REMARK 465     GLU H   285                                                      
REMARK 465     ILE H   286                                                      
REMARK 465     HIS H   287                                                      
REMARK 465     SER H   288                                                      
REMARK 465     ASP H   289                                                      
REMARK 465     GLN H   290                                                      
REMARK 465     ILE H   291                                                      
REMARK 465     THR H   292                                                      
REMARK 465     ALA H   293                                                      
REMARK 465     SER H   294                                                      
REMARK 465     SER H   295                                                      
REMARK 465     GLN H   296                                                      
REMARK 465     TYR H   297                                                      
REMARK 465     GLY H   298                                                      
REMARK 465     THR H   299                                                      
REMARK 465     ASN H   300                                                      
REMARK 465     TRP H   301                                                      
REMARK 465     SER H   302                                                      
REMARK 465     VAL H   303                                                      
REMARK 465     GLU H   304                                                      
REMARK 465     ARG H   305                                                      
REMARK 465     SER H   306                                                      
REMARK 465     ARG H   307                                                      
REMARK 465     LEU H   308                                                      
REMARK 465     ASN H   309                                                      
REMARK 465     TYR H   310                                                      
REMARK 465     PRO H   311                                                      
REMARK 465     GLU H   312                                                      
REMARK 465     ASN H   313                                                      
REMARK 465     GLY H   314                                                      
REMARK 465     TRP H   315                                                      
REMARK 465     THR H   316                                                      
REMARK 465     PRO H   317                                                      
REMARK 465     GLY H   318                                                      
REMARK 465     GLU H   319                                                      
REMARK 465     ASP H   320                                                      
REMARK 465     SER H   321                                                      
REMARK 465     TYR H   322                                                      
REMARK 465     LYS H   323                                                      
REMARK 465     GLU H   324                                                      
REMARK 465     TRP H   325                                                      
REMARK 465     ILE H   326                                                      
REMARK 465     GLN H   327                                                      
REMARK 465     VAL H   328                                                      
REMARK 465     ASP H   329                                                      
REMARK 465     LEU H   330                                                      
REMARK 465     GLY H   331                                                      
REMARK 465     LEU H   332                                                      
REMARK 465     LEU H   333                                                      
REMARK 465     ARG H   334                                                      
REMARK 465     PHE H   335                                                      
REMARK 465     VAL H   336                                                      
REMARK 465     THR H   337                                                      
REMARK 465     ALA H   338                                                      
REMARK 465     VAL H   339                                                      
REMARK 465     GLY H   340                                                      
REMARK 465     THR H   341                                                      
REMARK 465     GLN H   342                                                      
REMARK 465     GLY H   343                                                      
REMARK 465     ALA H   344                                                      
REMARK 465     ILE H   345                                                      
REMARK 465     SER H   346                                                      
REMARK 465     LYS H   347                                                      
REMARK 465     GLU H   348                                                      
REMARK 465     THR H   349                                                      
REMARK 465     LYS H   350                                                      
REMARK 465     LYS H   351                                                      
REMARK 465     LYS H   352                                                      
REMARK 465     TYR H   353                                                      
REMARK 465     TYR H   354                                                      
REMARK 465     VAL H   355                                                      
REMARK 465     LYS H   356                                                      
REMARK 465     THR H   357                                                      
REMARK 465     TYR H   358                                                      
REMARK 465     ARG H   359                                                      
REMARK 465     VAL H   360                                                      
REMARK 465     ASP H   361                                                      
REMARK 465     ILE H   362                                                      
REMARK 465     SER H   363                                                      
REMARK 465     SER H   364                                                      
REMARK 465     ASN H   365                                                      
REMARK 465     GLY H   366                                                      
REMARK 465     GLU H   367                                                      
REMARK 465     ASP H   368                                                      
REMARK 465     TRP H   369                                                      
REMARK 465     ILE H   370                                                      
REMARK 465     SER H   371                                                      
REMARK 465     LEU H   372                                                      
REMARK 465     LYS H   373                                                      
REMARK 465     GLU H   374                                                      
REMARK 465     GLY H   375                                                      
REMARK 465     ASN H   376                                                      
REMARK 465     LYS H   377                                                      
REMARK 465     ALA H   378                                                      
REMARK 465     ILE H   379                                                      
REMARK 465     ILE H   380                                                      
REMARK 465     PHE H   381                                                      
REMARK 465     GLN H   382                                                      
REMARK 465     GLY H   383                                                      
REMARK 465     ASN H   384                                                      
REMARK 465     THR H   385                                                      
REMARK 465     ASN H   386                                                      
REMARK 465     PRO H   387                                                      
REMARK 465     THR H   388                                                      
REMARK 465     ASP H   389                                                      
REMARK 465     VAL H   390                                                      
REMARK 465     VAL H   391                                                      
REMARK 465     LEU H   392                                                      
REMARK 465     GLY H   393                                                      
REMARK 465     VAL H   394                                                      
REMARK 465     PHE H   395                                                      
REMARK 465     SER H   396                                                      
REMARK 465     LYS H   397                                                      
REMARK 465     PRO H   398                                                      
REMARK 465     LEU H   399                                                      
REMARK 465     ILE H   400                                                      
REMARK 465     THR H   401                                                      
REMARK 465     ARG H   402                                                      
REMARK 465     PHE H   403                                                      
REMARK 465     VAL H   404                                                      
REMARK 465     ARG H   405                                                      
REMARK 465     ILE H   406                                                      
REMARK 465     LYS H   407                                                      
REMARK 465     PRO H   408                                                      
REMARK 465     VAL H   409                                                      
REMARK 465     SER H   410                                                      
REMARK 465     TRP H   411                                                      
REMARK 465     GLU H   412                                                      
REMARK 465     THR H   413                                                      
REMARK 465     GLY H   414                                                      
REMARK 465     ILE H   415                                                      
REMARK 465     SER H   416                                                      
REMARK 465     MET H   417                                                      
REMARK 465     ARG H   418                                                      
REMARK 465     PHE H   419                                                      
REMARK 465     GLU H   420                                                      
REMARK 465     VAL H   421                                                      
REMARK 465     TYR H   422                                                      
REMARK 465     GLY H   423                                                      
REMARK 465     CYS H   424                                                      
REMARK 465     LYS H   425                                                      
REMARK 465     ILE H   426                                                      
REMARK 465     THR H   427                                                      
REMARK 465     ASP H   428                                                      
REMARK 465     TYR H   429                                                      
REMARK 465     PRO H   430                                                      
REMARK 465     CYS H   431                                                      
REMARK 465     SER H   432                                                      
REMARK 465     GLY H   433                                                      
REMARK 465     MET H   434                                                      
REMARK 465     LEU H   435                                                      
REMARK 465     GLY H   436                                                      
REMARK 465     MET H   437                                                      
REMARK 465     VAL H   438                                                      
REMARK 465     SER H   439                                                      
REMARK 465     GLY H   440                                                      
REMARK 465     LEU H   441                                                      
REMARK 465     ILE H   442                                                      
REMARK 465     SER H   443                                                      
REMARK 465     ASP H   444                                                      
REMARK 465     SER H   445                                                      
REMARK 465     GLN H   446                                                      
REMARK 465     ILE H   447                                                      
REMARK 465     THR H   448                                                      
REMARK 465     ALA H   449                                                      
REMARK 465     SER H   450                                                      
REMARK 465     ASN H   451                                                      
REMARK 465     GLN H   452                                                      
REMARK 465     ALA H   453                                                      
REMARK 465     ASP H   454                                                      
REMARK 465     ARG H   455                                                      
REMARK 465     ASN H   456                                                      
REMARK 465     TRP H   457                                                      
REMARK 465     MET H   458                                                      
REMARK 465     PRO H   459                                                      
REMARK 465     GLU H   460                                                      
REMARK 465     ASN H   461                                                      
REMARK 465     ILE H   462                                                      
REMARK 465     ARG H   463                                                      
REMARK 465     LEU H   464                                                      
REMARK 465     VAL H   465                                                      
REMARK 465     THR H   466                                                      
REMARK 465     SER H   467                                                      
REMARK 465     ARG H   468                                                      
REMARK 465     THR H   469                                                      
REMARK 465     GLY H   470                                                      
REMARK 465     TRP H   471                                                      
REMARK 465     ALA H   472                                                      
REMARK 465     LEU H   473                                                      
REMARK 465     PRO H   474                                                      
REMARK 465     PRO H   475                                                      
REMARK 465     SER H   476                                                      
REMARK 465     PRO H   477                                                      
REMARK 465     HIS H   478                                                      
REMARK 465     PRO H   479                                                      
REMARK 465     TYR H   480                                                      
REMARK 465     THR H   481                                                      
REMARK 465     ASN H   482                                                      
REMARK 465     GLU H   483                                                      
REMARK 465     TRP H   484                                                      
REMARK 465     LEU H   485                                                      
REMARK 465     GLN H   486                                                      
REMARK 465     VAL H   487                                                      
REMARK 465     ASP H   488                                                      
REMARK 465     LEU H   489                                                      
REMARK 465     GLY H   490                                                      
REMARK 465     ASP H   491                                                      
REMARK 465     GLU H   492                                                      
REMARK 465     LYS H   493                                                      
REMARK 465     ILE H   494                                                      
REMARK 465     VAL H   495                                                      
REMARK 465     ARG H   496                                                      
REMARK 465     GLY H   497                                                      
REMARK 465     VAL H   498                                                      
REMARK 465     ILE H   499                                                      
REMARK 465     ILE H   500                                                      
REMARK 465     GLN H   501                                                      
REMARK 465     GLY H   502                                                      
REMARK 465     GLY H   503                                                      
REMARK 465     LYS H   504                                                      
REMARK 465     HIS H   505                                                      
REMARK 465     ARG H   506                                                      
REMARK 465     GLU H   507                                                      
REMARK 465     ASN H   508                                                      
REMARK 465     LYS H   509                                                      
REMARK 465     VAL H   510                                                      
REMARK 465     PHE H   511                                                      
REMARK 465     MET H   512                                                      
REMARK 465     ARG H   513                                                      
REMARK 465     LYS H   514                                                      
REMARK 465     PHE H   515                                                      
REMARK 465     LYS H   516                                                      
REMARK 465     ILE H   517                                                      
REMARK 465     ALA H   518                                                      
REMARK 465     TYR H   519                                                      
REMARK 465     SER H   520                                                      
REMARK 465     ASN H   521                                                      
REMARK 465     ASN H   522                                                      
REMARK 465     GLY H   523                                                      
REMARK 465     SER H   524                                                      
REMARK 465     ASP H   525                                                      
REMARK 465     TRP H   526                                                      
REMARK 465     LYS H   527                                                      
REMARK 465     THR H   528                                                      
REMARK 465     ILE H   529                                                      
REMARK 465     MET H   530                                                      
REMARK 465     ASP H   531                                                      
REMARK 465     ASP H   532                                                      
REMARK 465     SER H   533                                                      
REMARK 465     LYS H   534                                                      
REMARK 465     ARG H   535                                                      
REMARK 465     LYS H   536                                                      
REMARK 465     ALA H   537                                                      
REMARK 465     LYS H   538                                                      
REMARK 465     SER H   539                                                      
REMARK 465     PHE H   540                                                      
REMARK 465     GLU H   541                                                      
REMARK 465     GLY H   542                                                      
REMARK 465     ASN H   543                                                      
REMARK 465     ASN H   544                                                      
REMARK 465     ASN H   545                                                      
REMARK 465     TYR H   546                                                      
REMARK 465     ASP H   547                                                      
REMARK 465     THR H   548                                                      
REMARK 465     PRO H   549                                                      
REMARK 465     GLU H   550                                                      
REMARK 465     LEU H   551                                                      
REMARK 465     ARG H   552                                                      
REMARK 465     THR H   553                                                      
REMARK 465     PHE H   554                                                      
REMARK 465     SER H   555                                                      
REMARK 465     PRO H   556                                                      
REMARK 465     LEU H   557                                                      
REMARK 465     SER H   558                                                      
REMARK 465     THR H   559                                                      
REMARK 465     ARG H   560                                                      
REMARK 465     PHE H   561                                                      
REMARK 465     ILE H   562                                                      
REMARK 465     ARG H   563                                                      
REMARK 465     ILE H   564                                                      
REMARK 465     TYR H   565                                                      
REMARK 465     PRO H   566                                                      
REMARK 465     GLU H   567                                                      
REMARK 465     ARG H   568                                                      
REMARK 465     ALA H   569                                                      
REMARK 465     THR H   570                                                      
REMARK 465     HIS H   571                                                      
REMARK 465     SER H   572                                                      
REMARK 465     GLY H   573                                                      
REMARK 465     LEU H   574                                                      
REMARK 465     GLY H   575                                                      
REMARK 465     LEU H   576                                                      
REMARK 465     ARG H   577                                                      
REMARK 465     MET H   578                                                      
REMARK 465     GLU H   579                                                      
REMARK 465     LEU H   580                                                      
REMARK 465     LEU H   581                                                      
REMARK 465     GLY H   582                                                      
REMARK 465     CYS H   583                                                      
REMARK 465     GLU H   584                                                      
REMARK 465     VAL H   585                                                      
REMARK 465     GLU H   586                                                      
REMARK 465     ARG H   587                                                      
REMARK 465     THR H   588                                                      
REMARK 465     LYS H   589                                                      
REMARK 465     HIS H   590                                                      
REMARK 465     HIS H   591                                                      
REMARK 465     HIS H   592                                                      
REMARK 465     HIS H   593                                                      
REMARK 465     HIS H   594                                                      
REMARK 465     HIS H   595                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   NE2  GLN A   345     OE1  GLU H   128              0.46            
REMARK 500   CE2  PHE D   690     CB   ARG E   540              0.52            
REMARK 500   OE1  GLN D   610     CD1  LEU F   577              0.72            
REMARK 500   CE2  PHE B   690     CG   ARG D   540              0.80            
REMARK 500   CD   ARG A   540     CG   PHE C   690              0.81            
REMARK 500   CZ   PHE D   690     CB   ARG E   540              0.96            
REMARK 500   CD1  TYR A    95     NH2  ARG G   277              0.96            
REMARK 500   CE1  PHE B   690     CZ   ARG D   540              1.01            
REMARK 500   O    SER C   523     CE1  HIS D   465              1.02            
REMARK 500   CD2  PHE B   690     CD   ARG D   540              1.04            
REMARK 500   NE   ARG C   540     CE1  PHE F   690              1.04            
REMARK 500   OE2  GLU A   306     NZ   LYS H    83              1.05            
REMARK 500   O    TYR C   654     N    ASN C   655              1.06            
REMARK 500   OE1  GLN B   660     CZ2  TRP G   105              1.09            
REMARK 500   NH1  ARG A   540     CD1  PHE C   690              1.09            
REMARK 500   O    TYR D   654     N    ASN D   655              1.10            
REMARK 500   CD   ARG A   540     CB   PHE C   690              1.13            
REMARK 500   CD1  PHE B   690     NE   ARG D   540              1.13            
REMARK 500   CZ   ARG A   540     CD1  PHE C   690              1.17            
REMARK 500   CE1  PHE B   690     NE   ARG D   540              1.18            
REMARK 500   CZ   PHE A   275     CG   ARG H    80              1.19            
REMARK 500   CA   ASN A   441     OE1  GLN C   691              1.22            
REMARK 500   CE2  PHE B   690     CD   ARG D   540              1.22            
REMARK 500   CG   ARG A   540     CD2  PHE C   690              1.33            
REMARK 500   CA   GLY C   518     NE2  GLN D   324              1.34            
REMARK 500   CE1  HIS A   465     O    SER B   523              1.38            
REMARK 500   OD2  ASP A   408     CB   PHE G   194              1.39            
REMARK 500   O    SER A   523     CE1  HIS B   465              1.40            
REMARK 500   CE1  PHE B   690     NH2  ARG D   540              1.42            
REMARK 500   CD   ARG C   540     CZ   PHE F   690              1.43            
REMARK 500   CB   ARG C   540     CZ   PHE F   690              1.43            
REMARK 500   CB   ARG C   540     CE2  PHE F   690              1.44            
REMARK 500   CA   GLY A   518     NE2  GLN B   324              1.45            
REMARK 500   CG   PHE B   690     NE   ARG D   540              1.46            
REMARK 500   NE2  GLN A   324     CA   GLY B   518              1.47            
REMARK 500   CG   ARG C   540     CZ   PHE F   690              1.48            
REMARK 500   CE2  PHE B   690     CB   ARG D   540              1.48            
REMARK 500   CD1  LEU E   626     CB   PRO F   399              1.50            
REMARK 500   CE2  PHE D   690     CG   ARG E   540              1.50            
REMARK 500   O    TYR E   654     N    ASN E   655              1.51            
REMARK 500   CZ   PHE B   690     NE   ARG D   540              1.51            
REMARK 500   OE1  GLN D   691     N    GLY E   442              1.52            
REMARK 500   NE2  GLN A   345     CD   GLU H   128              1.53            
REMARK 500   NE   ARG A   540     CD1  PHE C   690              1.55            
REMARK 500   CD   GLN A   345     OE1  GLU H   128              1.55            
REMARK 500   OD2  ASP A   408     CG   PHE G   194              1.57            
REMARK 500   N    GLY C   518     NE2  GLN D   324              1.57            
REMARK 500   N    LEU A   274     NH2  ARG H    80              1.57            
REMARK 500   CD   GLN D   610     CD1  LEU F   577              1.59            
REMARK 500   NE   ARG A   540     CG   PHE C   690              1.59            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     139 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS                                             
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC             
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15          
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A           
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375             
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE               
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.            
REMARK 500                                                                      
REMARK 500 DISTANCE CUTOFF:                                                     
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS              
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS                  
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE          
REMARK 500   CE1  PHE A   690     NE   ARG F   540     3455     0.68            
REMARK 500   CE2  PHE A   690     CG   ARG F   540     3455     0.78            
REMARK 500   N    ASP B   541     CE2  PHE E   690     3455     0.79            
REMARK 500   CD1  LEU A   577     OE1  GLN E   610     3455     0.87            
REMARK 500   C    ARG B   540     CZ   PHE E   690     3455     0.87            
REMARK 500   CB   ARG B   540     CE1  PHE E   690     3455     0.88            
REMARK 500   CZ   PHE G   386     ND2  ASN H    72     2554     0.89            
REMARK 500   CE1  PHE A   690     CZ   ARG F   540     3455     0.94            
REMARK 500   CG   LEU A   577     OE1  GLN E   610     3455     1.00            
REMARK 500   CE2  PHE A   690     CD   ARG F   540     3455     1.06            
REMARK 500   N    ASP B   541     CZ   PHE E   690     3455     1.06            
REMARK 500   NE2  GLN G   365     NE2  GLN G   365     2554     1.13            
REMARK 500   CD1  PHE A   690     NE   ARG F   540     3455     1.20            
REMARK 500   CE1  PHE G   386     ND2  ASN H    72     2554     1.21            
REMARK 500   CD2  PHE A   690     CD   ARG F   540     3455     1.21            
REMARK 500   CZ   PHE A   690     NE   ARG F   540     3455     1.22            
REMARK 500   OE1  GLN A   610     CD1  LEU E   577     3455     1.30            
REMARK 500   OE2  GLU A   692     N    ASN F   441     3455     1.30            
REMARK 500   CD1  LEU A   577     CD   GLN E   610     3455     1.31            
REMARK 500   CA   ASP B   541     CE2  PHE E   690     3455     1.35            
REMARK 500   OE1  GLN A   610     CG   LEU E   577     3455     1.39            
REMARK 500   CG2  THR G   385     NH1  ARG H   137     2554     1.43            
REMARK 500   CA   ARG B   540     CE1  PHE E   690     3455     1.45            
REMARK 500   CE2  PHE A   690     CB   ARG F   540     3455     1.47            
REMARK 500   CZ   PHE G   386     CG   ASN H    72     2554     1.49            
REMARK 500   N    ASN B   441     OE1  GLN E   691     3455     1.50            
REMARK 500   CA   ARG B   540     CZ   PHE E   690     3455     1.51            
REMARK 500   CE   LYS G   259     O    ASN G   299     2554     1.58            
REMARK 500   CZ   PHE A   690     CD   ARG F   540     3455     1.62            
REMARK 500   CE1  PHE A   690     NH2  ARG F   540     3455     1.66            
REMARK 500   CA   GLN G   365     OE1  GLN G   365     2554     1.70            
REMARK 500   CD   ARG B   540     O    SER E   689     3455     1.71            
REMARK 500   CZ   PHE A   690     CG   ARG F   540     3455     1.72            
REMARK 500   CB   ARG B   540     CD1  PHE E   690     3455     1.81            
REMARK 500   CZ   PHE A   690     CZ   ARG F   540     3455     1.81            
REMARK 500   CG   PHE A   690     CD   ARG F   540     3455     1.82            
REMARK 500   C    ARG B   540     CE2  PHE E   690     3455     1.85            
REMARK 500   CE2  PHE A   690     NE   ARG F   540     3455     1.87            
REMARK 500   OE1  GLN A   610     CB   LEU E   577     3455     1.87            
REMARK 500   CG   PHE A   690     NE   ARG F   540     3455     1.87            
REMARK 500   OE2  GLU A   692     CA   ASN F   441     3455     1.90            
REMARK 500   CD   GLN G   365     NE2  GLN G   365     2554     1.92            
REMARK 500   CD   LYS G   259     CA   GLY G   300     2554     1.93            
REMARK 500   CD1  PHE A   690     CZ   ARG F   540     3455     1.94            
REMARK 500   CD2  PHE A   690     CG   ARG F   540     3455     1.98            
REMARK 500   CB   LEU A   577     NE2  GLN E   610     3455     2.00            
REMARK 500   CG   LEU A   577     CD   GLN E   610     3455     2.01            
REMARK 500   O    ARG B   540     CZ   PHE E   690     3455     2.02            
REMARK 500   CD   LYS G   259     C    GLY G   300     2554     2.03            
REMARK 500   CD   GLN A   610     CD1  LEU E   577     3455     2.04            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      63 SYMMETRY CONTACTS                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    TYR A 654   C     ASN A 655   N       0.187                       
REMARK 500    VAL C 508   C     GLU C 509   N      -0.483                       
REMARK 500    VAL D 508   C     GLU D 509   N      -0.240                       
REMARK 500    TYR D 654   C     ASN D 655   N      -0.286                       
REMARK 500    CYS E 559   C     MET E 560   N      -0.150                       
REMARK 500    VAL F 508   C     GLU F 509   N       0.298                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    TYR A 654   O   -  C   -  N   ANGL. DEV. = -16.9 DEGREES          
REMARK 500    VAL B 508   O   -  C   -  N   ANGL. DEV. = -18.7 DEGREES          
REMARK 500    TYR B 654   CA  -  C   -  N   ANGL. DEV. =  19.3 DEGREES          
REMARK 500    TYR B 654   O   -  C   -  N   ANGL. DEV. = -20.5 DEGREES          
REMARK 500    ASN B 655   C   -  N   -  CA  ANGL. DEV. =  30.4 DEGREES          
REMARK 500    VAL C 508   O   -  C   -  N   ANGL. DEV. = -19.8 DEGREES          
REMARK 500    TYR C 654   CA  -  C   -  N   ANGL. DEV. =  25.1 DEGREES          
REMARK 500    TYR C 654   O   -  C   -  N   ANGL. DEV. = -71.3 DEGREES          
REMARK 500    VAL D 508   CA  -  C   -  N   ANGL. DEV. = -18.5 DEGREES          
REMARK 500    GLU D 509   C   -  N   -  CA  ANGL. DEV. = -20.8 DEGREES          
REMARK 500    TYR D 654   CA  -  C   -  N   ANGL. DEV. =  16.4 DEGREES          
REMARK 500    TYR D 654   O   -  C   -  N   ANGL. DEV. = -65.6 DEGREES          
REMARK 500    CYS E 559   CA  -  C   -  N   ANGL. DEV. = -19.1 DEGREES          
REMARK 500    CYS E 559   O   -  C   -  N   ANGL. DEV. =  17.3 DEGREES          
REMARK 500    MET E 560   C   -  N   -  CA  ANGL. DEV. = -20.6 DEGREES          
REMARK 500    TYR E 654   CA  -  C   -  N   ANGL. DEV. =  48.1 DEGREES          
REMARK 500    TYR E 654   O   -  C   -  N   ANGL. DEV. = -50.4 DEGREES          
REMARK 500    ASN E 655   C   -  N   -  CA  ANGL. DEV. =  52.4 DEGREES          
REMARK 500    VAL F 508   O   -  C   -  N   ANGL. DEV. = -14.4 DEGREES          
REMARK 500    GLU F 509   C   -  N   -  CA  ANGL. DEV. =  18.1 DEGREES          
REMARK 500    CYS F 559   CA  -  C   -  N   ANGL. DEV. = -25.4 DEGREES          
REMARK 500    CYS F 559   O   -  C   -  N   ANGL. DEV. = -12.4 DEGREES          
REMARK 500    MET F 560   C   -  N   -  CA  ANGL. DEV. = -23.9 DEGREES          
REMARK 500    TYR F 654   CA  -  C   -  N   ANGL. DEV. = -24.7 DEGREES          
REMARK 500    ASN F 655   C   -  N   -  CA  ANGL. DEV. = -20.8 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASN A  51      -50.33   -122.34                                   
REMARK 500    LEU A  77       42.42     70.08                                   
REMARK 500    SER A 152       18.09   -160.00                                   
REMARK 500    SER A 160      143.81    167.68                                   
REMARK 500    SER A 175     -156.48    -68.16                                   
REMARK 500    ASP A 287       71.49   -168.09                                   
REMARK 500    PRO A 397       58.92    -68.38                                   
REMARK 500    ARG A 429      -44.94   -133.01                                   
REMARK 500    ASN A 550       19.54     59.08                                   
REMARK 500    ASP A 700       43.33   -108.71                                   
REMARK 500    ASN B  51      -50.39   -122.29                                   
REMARK 500    LEU B  77       42.40     70.07                                   
REMARK 500    SER B 152       18.10   -159.99                                   
REMARK 500    SER B 160      143.76    167.88                                   
REMARK 500    SER B 175     -156.61    -68.26                                   
REMARK 500    ASP B 287       71.52   -168.15                                   
REMARK 500    PRO B 397       58.91    -68.42                                   
REMARK 500    ARG B 429      -44.85   -133.04                                   
REMARK 500    VAL B 508        9.14    -55.47                                   
REMARK 500    GLU B 509      143.16    174.68                                   
REMARK 500    ASN B 550       19.54     59.16                                   
REMARK 500    ASP B 700       43.29   -108.73                                   
REMARK 500    ASN C  51      -50.31   -122.22                                   
REMARK 500    LEU C  77       42.23     70.16                                   
REMARK 500    SER C 152       17.99   -159.97                                   
REMARK 500    SER C 160      143.79    167.77                                   
REMARK 500    SER C 175     -156.54    -68.21                                   
REMARK 500    ASP C 287       71.62   -168.16                                   
REMARK 500    PRO C 397       58.90    -68.40                                   
REMARK 500    ARG C 429      -44.91   -133.00                                   
REMARK 500    VAL C 508        3.27    -55.48                                   
REMARK 500    GLU C 509      143.03    175.48                                   
REMARK 500    ASN C 550       19.42     59.21                                   
REMARK 500    TYR C 654      -86.42   -127.22                                   
REMARK 500    ASN C 655       95.23    102.43                                   
REMARK 500    ASP C 700       43.42   -108.68                                   
REMARK 500    ASN D  51      -50.40   -122.22                                   
REMARK 500    LEU D  77       42.44     70.06                                   
REMARK 500    SER D 152       18.04   -159.87                                   
REMARK 500    SER D 160      143.70    167.81                                   
REMARK 500    SER D 175     -156.47    -68.07                                   
REMARK 500    ASP D 287       71.50   -168.09                                   
REMARK 500    PRO D 397       59.02    -68.49                                   
REMARK 500    ARG D 429      -44.91   -133.11                                   
REMARK 500    VAL D 508       -0.31    -55.34                                   
REMARK 500    GLU D 509      143.09   -170.55                                   
REMARK 500    ASN D 550       19.33     59.28                                   
REMARK 500    TYR D 654      -92.97   -127.21                                   
REMARK 500    ASN D 655       95.21    111.83                                   
REMARK 500    ASP D 700       43.43   -108.63                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     124 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 ARG H   80     ASP H   81                 -149.11                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500    TYR G  57         0.08    SIDE CHAIN                              
REMARK 500    TYR G 429         0.07    SIDE CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    TYR A 654         21.26                                           
REMARK 500    VAL B 508        -22.78                                           
REMARK 500    VAL C 508        -22.98                                           
REMARK 500    TYR C 654        -77.72                                           
REMARK 500    VAL D 508        -16.77                                           
REMARK 500    TYR D 654        -68.34                                           
REMARK 500    TYR E 654         17.62                                           
REMARK 500    CYS F 559        -29.50                                           
REMARK 500    TYR F 654         25.44                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA H 601  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 THR H 129   O                                                      
REMARK 620 2 ASP H  85   OD2  86.5                                              
REMARK 620 3 ASP H 126   OD1 171.5 102.0                                        
REMARK 620 4 GLU H 128   O    70.0 147.8 102.6                                  
REMARK 620 5 GLU H  78   OE1  81.9  85.3  97.5 111.7                            
REMARK 620 N                    1     2     3     4                             
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA H 601                  
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 4GZ8   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 4GZ9   RELATED DB: PDB                                   
REMARK 999                                                                      
REMARK 999 SEQUENCE                                                             
REMARK 999 THE SEQUENCE OF CHAIN G IS BASED ON NCBI REFERENCE SEQUENCE: NP_     
REMARK 999 033178.2. RESIDUE 475 IS A VAL IN THIS DATABASE SEQUENCE.            
DBREF  4GZA A   33   703  UNP    P70207   PLXA2_MOUSE     33    703             
DBREF  4GZA B   33   703  UNP    P70207   PLXA2_MOUSE     33    703             
DBREF  4GZA C   33   703  UNP    P70207   PLXA2_MOUSE     33    703             
DBREF  4GZA D   33   703  UNP    P70207   PLXA2_MOUSE     33    703             
DBREF  4GZA E   33   703  UNP    P70207   PLXA2_MOUSE     33    703             
DBREF  4GZA F   33   703  UNP    P70207   PLXA2_MOUSE     33    703             
DBREF  4GZA G   21   555  UNP    O08665   SEM3A_MOUSE     21    555             
DBREF  4GZA H   22   586  UNP    P97333   NRP1_MOUSE      22    586             
SEQADV 4GZA GLU A   32  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA GLY A  704  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA THR A  705  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA LYS A  706  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS A  707  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS A  708  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS A  709  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS A  710  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS A  711  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS A  712  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA GLU B   32  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA GLY B  704  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA THR B  705  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA LYS B  706  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS B  707  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS B  708  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS B  709  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS B  710  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS B  711  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS B  712  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA GLU C   32  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA GLY C  704  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA THR C  705  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA LYS C  706  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS C  707  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS C  708  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS C  709  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS C  710  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS C  711  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS C  712  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA GLU D   32  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA GLY D  704  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA THR D  705  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA LYS D  706  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS D  707  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS D  708  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS D  709  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS D  710  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS D  711  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS D  712  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA GLU E   32  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA GLY E  704  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA THR E  705  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA LYS E  706  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS E  707  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS E  708  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS E  709  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS E  710  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS E  711  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS E  712  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA GLU F   32  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA GLY F  704  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA THR F  705  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA LYS F  706  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS F  707  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS F  708  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS F  709  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS F  710  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS F  711  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA HIS F  712  UNP  P70207              EXPRESSION TAG                 
SEQADV 4GZA GLU G   18  UNP  O08665              EXPRESSION TAG                 
SEQADV 4GZA THR G   19  UNP  O08665              EXPRESSION TAG                 
SEQADV 4GZA GLY G   20  UNP  O08665              EXPRESSION TAG                 
SEQADV 4GZA VAL G  475  UNP  O08665    ILE   475 SEE REMARK 999                 
SEQADV 4GZA GLU H   19  UNP  P97333              EXPRESSION TAG                 
SEQADV 4GZA THR H   20  UNP  P97333              EXPRESSION TAG                 
SEQADV 4GZA GLY H   21  UNP  P97333              EXPRESSION TAG                 
SEQADV 4GZA ARG H  587  UNP  P97333              EXPRESSION TAG                 
SEQADV 4GZA THR H  588  UNP  P97333              EXPRESSION TAG                 
SEQADV 4GZA LYS H  589  UNP  P97333              EXPRESSION TAG                 
SEQADV 4GZA HIS H  590  UNP  P97333              EXPRESSION TAG                 
SEQADV 4GZA HIS H  591  UNP  P97333              EXPRESSION TAG                 
SEQADV 4GZA HIS H  592  UNP  P97333              EXPRESSION TAG                 
SEQADV 4GZA HIS H  593  UNP  P97333              EXPRESSION TAG                 
SEQADV 4GZA HIS H  594  UNP  P97333              EXPRESSION TAG                 
SEQADV 4GZA HIS H  595  UNP  P97333              EXPRESSION TAG                 
SEQRES   1 A  681  GLU THR GLY MET PRO GLN TYR SER THR PHE HIS SER GLU          
SEQRES   2 A  681  ASN ARG ASP TRP THR PHE ASN HIS LEU THR VAL HIS ARG          
SEQRES   3 A  681  ARG THR GLY ALA VAL TYR VAL GLY ALA ILE ASN ARG VAL          
SEQRES   4 A  681  TYR LYS LEU THR GLY ASN LEU THR ILE GLN VAL ALA HIS          
SEQRES   5 A  681  LYS THR GLY PRO GLU GLU ASP ASN LYS ALA CYS TYR PRO          
SEQRES   6 A  681  PRO LEU ILE VAL GLN PRO CYS SER GLU VAL LEU THR LEU          
SEQRES   7 A  681  THR ASN ASN VAL ASN LYS LEU LEU ILE ILE ASP TYR SER          
SEQRES   8 A  681  GLU ASN ARG LEU LEU ALA CYS GLY SER LEU TYR GLN GLY          
SEQRES   9 A  681  VAL CYS LYS LEU LEU ARG LEU ASP ASP LEU PHE ILE LEU          
SEQRES  10 A  681  VAL GLU PRO SER HIS LYS LYS GLU HIS TYR LEU SER SER          
SEQRES  11 A  681  VAL ASN LYS THR GLY THR MET TYR GLY VAL ILE VAL ARG          
SEQRES  12 A  681  SER GLU GLY GLU ASP GLY LYS LEU PHE ILE GLY THR ALA          
SEQRES  13 A  681  VAL ASP GLY LYS GLN ASP TYR PHE PRO THR LEU SER SER          
SEQRES  14 A  681  ARG LYS LEU PRO ARG ASP PRO GLU SER SER ALA MET LEU          
SEQRES  15 A  681  ASP TYR GLU LEU HIS SER ASP PHE VAL SER SER LEU ILE          
SEQRES  16 A  681  LYS ILE PRO SER ASP THR LEU ALA LEU VAL SER HIS PHE          
SEQRES  17 A  681  ASP ILE PHE TYR ILE TYR GLY PHE ALA SER GLY GLY PHE          
SEQRES  18 A  681  VAL TYR PHE LEU THR VAL GLN PRO GLU THR PRO ASP GLY          
SEQRES  19 A  681  MET ALA ILE ASN SER ALA GLY ASP LEU PHE TYR THR SER          
SEQRES  20 A  681  ARG ILE VAL ARG LEU CYS LYS ASP ASP PRO LYS PHE HIS          
SEQRES  21 A  681  SER TYR VAL SER LEU PRO PHE GLY CYS THR ARG ALA GLY          
SEQRES  22 A  681  VAL GLU TYR ARG LEU LEU GLN ALA ALA TYR LEU ALA LYS          
SEQRES  23 A  681  PRO GLY GLU ALA LEU ALA GLN ALA PHE ASN ILE SER SER          
SEQRES  24 A  681  ASP GLU ASP VAL LEU PHE ALA ILE PHE SER LYS GLY GLN          
SEQRES  25 A  681  LYS GLN TYR HIS HIS PRO PRO ASP ASP SER ALA LEU CYS          
SEQRES  26 A  681  ALA PHE PRO ILE ARG ALA ILE ASN LEU GLN ILE LYS GLU          
SEQRES  27 A  681  ARG LEU GLN SER CYS TYR HIS GLY GLU GLY ASN LEU GLU          
SEQRES  28 A  681  LEU ASN TRP LEU LEU GLY LYS ASP VAL GLN CYS THR LYS          
SEQRES  29 A  681  ALA PRO VAL PRO ILE ASP ASP ASN PHE CYS GLY LEU ASP          
SEQRES  30 A  681  ILE ASN GLN PRO LEU GLY GLY SER THR PRO VAL GLU GLY          
SEQRES  31 A  681  LEU THR LEU TYR THR THR SER ARG ASP ARG LEU THR SER          
SEQRES  32 A  681  VAL ALA SER TYR VAL TYR ASN GLY TYR SER VAL VAL PHE          
SEQRES  33 A  681  VAL GLY THR LYS SER GLY LYS LEU LYS LYS ILE ARG ALA          
SEQRES  34 A  681  ASP GLY PRO PRO HIS GLY GLY VAL GLN TYR GLU MET VAL          
SEQRES  35 A  681  SER VAL PHE LYS ASP GLY SER PRO ILE LEU ARG ASP MET          
SEQRES  36 A  681  ALA PHE SER ILE ASN GLN LEU TYR LEU TYR VAL MET SER          
SEQRES  37 A  681  GLU ARG GLN VAL THR ARG VAL PRO VAL GLU SER CYS GLU          
SEQRES  38 A  681  GLN TYR THR THR CYS GLY GLU CYS LEU SER SER GLY ASP          
SEQRES  39 A  681  PRO HIS CYS GLY TRP CYS ALA LEU HIS ASN MET CYS SER          
SEQRES  40 A  681  ARG ARG ASP LYS CYS GLN ARG ALA TRP GLU ALA ASN ARG          
SEQRES  41 A  681  PHE ALA ALA SER ILE SER GLN CYS MET SER LEU GLU VAL          
SEQRES  42 A  681  HIS PRO ASN SER ILE SER VAL SER ASP HIS SER ARG LEU          
SEQRES  43 A  681  LEU SER LEU VAL VAL ASN ASP ALA PRO ASN LEU SER GLU          
SEQRES  44 A  681  GLY ILE ALA CYS ALA PHE GLY ASN LEU THR GLU VAL GLU          
SEQRES  45 A  681  GLY GLN VAL SER GLY SER GLN VAL ILE CYS ILE SER PRO          
SEQRES  46 A  681  GLY PRO LYS ASP VAL PRO VAL ILE PRO LEU ASP GLN ASP          
SEQRES  47 A  681  TRP PHE GLY LEU GLU LEU GLN LEU ARG SER LYS GLU THR          
SEQRES  48 A  681  GLY LYS ILE PHE VAL SER THR GLU PHE LYS PHE TYR ASN          
SEQRES  49 A  681  CYS SER ALA HIS GLN LEU CYS LEU SER CYS VAL ASN SER          
SEQRES  50 A  681  ALA PHE ARG CYS HIS TRP CYS LYS TYR ARG ASN LEU CYS          
SEQRES  51 A  681  THR HIS ASP PRO THR THR CYS SER PHE GLN GLU GLY ARG          
SEQRES  52 A  681  ILE ASN VAL SER GLU ASP CYS PRO GLN GLY THR LYS HIS          
SEQRES  53 A  681  HIS HIS HIS HIS HIS                                          
SEQRES   1 B  681  GLU THR GLY MET PRO GLN TYR SER THR PHE HIS SER GLU          
SEQRES   2 B  681  ASN ARG ASP TRP THR PHE ASN HIS LEU THR VAL HIS ARG          
SEQRES   3 B  681  ARG THR GLY ALA VAL TYR VAL GLY ALA ILE ASN ARG VAL          
SEQRES   4 B  681  TYR LYS LEU THR GLY ASN LEU THR ILE GLN VAL ALA HIS          
SEQRES   5 B  681  LYS THR GLY PRO GLU GLU ASP ASN LYS ALA CYS TYR PRO          
SEQRES   6 B  681  PRO LEU ILE VAL GLN PRO CYS SER GLU VAL LEU THR LEU          
SEQRES   7 B  681  THR ASN ASN VAL ASN LYS LEU LEU ILE ILE ASP TYR SER          
SEQRES   8 B  681  GLU ASN ARG LEU LEU ALA CYS GLY SER LEU TYR GLN GLY          
SEQRES   9 B  681  VAL CYS LYS LEU LEU ARG LEU ASP ASP LEU PHE ILE LEU          
SEQRES  10 B  681  VAL GLU PRO SER HIS LYS LYS GLU HIS TYR LEU SER SER          
SEQRES  11 B  681  VAL ASN LYS THR GLY THR MET TYR GLY VAL ILE VAL ARG          
SEQRES  12 B  681  SER GLU GLY GLU ASP GLY LYS LEU PHE ILE GLY THR ALA          
SEQRES  13 B  681  VAL ASP GLY LYS GLN ASP TYR PHE PRO THR LEU SER SER          
SEQRES  14 B  681  ARG LYS LEU PRO ARG ASP PRO GLU SER SER ALA MET LEU          
SEQRES  15 B  681  ASP TYR GLU LEU HIS SER ASP PHE VAL SER SER LEU ILE          
SEQRES  16 B  681  LYS ILE PRO SER ASP THR LEU ALA LEU VAL SER HIS PHE          
SEQRES  17 B  681  ASP ILE PHE TYR ILE TYR GLY PHE ALA SER GLY GLY PHE          
SEQRES  18 B  681  VAL TYR PHE LEU THR VAL GLN PRO GLU THR PRO ASP GLY          
SEQRES  19 B  681  MET ALA ILE ASN SER ALA GLY ASP LEU PHE TYR THR SER          
SEQRES  20 B  681  ARG ILE VAL ARG LEU CYS LYS ASP ASP PRO LYS PHE HIS          
SEQRES  21 B  681  SER TYR VAL SER LEU PRO PHE GLY CYS THR ARG ALA GLY          
SEQRES  22 B  681  VAL GLU TYR ARG LEU LEU GLN ALA ALA TYR LEU ALA LYS          
SEQRES  23 B  681  PRO GLY GLU ALA LEU ALA GLN ALA PHE ASN ILE SER SER          
SEQRES  24 B  681  ASP GLU ASP VAL LEU PHE ALA ILE PHE SER LYS GLY GLN          
SEQRES  25 B  681  LYS GLN TYR HIS HIS PRO PRO ASP ASP SER ALA LEU CYS          
SEQRES  26 B  681  ALA PHE PRO ILE ARG ALA ILE ASN LEU GLN ILE LYS GLU          
SEQRES  27 B  681  ARG LEU GLN SER CYS TYR HIS GLY GLU GLY ASN LEU GLU          
SEQRES  28 B  681  LEU ASN TRP LEU LEU GLY LYS ASP VAL GLN CYS THR LYS          
SEQRES  29 B  681  ALA PRO VAL PRO ILE ASP ASP ASN PHE CYS GLY LEU ASP          
SEQRES  30 B  681  ILE ASN GLN PRO LEU GLY GLY SER THR PRO VAL GLU GLY          
SEQRES  31 B  681  LEU THR LEU TYR THR THR SER ARG ASP ARG LEU THR SER          
SEQRES  32 B  681  VAL ALA SER TYR VAL TYR ASN GLY TYR SER VAL VAL PHE          
SEQRES  33 B  681  VAL GLY THR LYS SER GLY LYS LEU LYS LYS ILE ARG ALA          
SEQRES  34 B  681  ASP GLY PRO PRO HIS GLY GLY VAL GLN TYR GLU MET VAL          
SEQRES  35 B  681  SER VAL PHE LYS ASP GLY SER PRO ILE LEU ARG ASP MET          
SEQRES  36 B  681  ALA PHE SER ILE ASN GLN LEU TYR LEU TYR VAL MET SER          
SEQRES  37 B  681  GLU ARG GLN VAL THR ARG VAL PRO VAL GLU SER CYS GLU          
SEQRES  38 B  681  GLN TYR THR THR CYS GLY GLU CYS LEU SER SER GLY ASP          
SEQRES  39 B  681  PRO HIS CYS GLY TRP CYS ALA LEU HIS ASN MET CYS SER          
SEQRES  40 B  681  ARG ARG ASP LYS CYS GLN ARG ALA TRP GLU ALA ASN ARG          
SEQRES  41 B  681  PHE ALA ALA SER ILE SER GLN CYS MET SER LEU GLU VAL          
SEQRES  42 B  681  HIS PRO ASN SER ILE SER VAL SER ASP HIS SER ARG LEU          
SEQRES  43 B  681  LEU SER LEU VAL VAL ASN ASP ALA PRO ASN LEU SER GLU          
SEQRES  44 B  681  GLY ILE ALA CYS ALA PHE GLY ASN LEU THR GLU VAL GLU          
SEQRES  45 B  681  GLY GLN VAL SER GLY SER GLN VAL ILE CYS ILE SER PRO          
SEQRES  46 B  681  GLY PRO LYS ASP VAL PRO VAL ILE PRO LEU ASP GLN ASP          
SEQRES  47 B  681  TRP PHE GLY LEU GLU LEU GLN LEU ARG SER LYS GLU THR          
SEQRES  48 B  681  GLY LYS ILE PHE VAL SER THR GLU PHE LYS PHE TYR ASN          
SEQRES  49 B  681  CYS SER ALA HIS GLN LEU CYS LEU SER CYS VAL ASN SER          
SEQRES  50 B  681  ALA PHE ARG CYS HIS TRP CYS LYS TYR ARG ASN LEU CYS          
SEQRES  51 B  681  THR HIS ASP PRO THR THR CYS SER PHE GLN GLU GLY ARG          
SEQRES  52 B  681  ILE ASN VAL SER GLU ASP CYS PRO GLN GLY THR LYS HIS          
SEQRES  53 B  681  HIS HIS HIS HIS HIS                                          
SEQRES   1 C  681  GLU THR GLY MET PRO GLN TYR SER THR PHE HIS SER GLU          
SEQRES   2 C  681  ASN ARG ASP TRP THR PHE ASN HIS LEU THR VAL HIS ARG          
SEQRES   3 C  681  ARG THR GLY ALA VAL TYR VAL GLY ALA ILE ASN ARG VAL          
SEQRES   4 C  681  TYR LYS LEU THR GLY ASN LEU THR ILE GLN VAL ALA HIS          
SEQRES   5 C  681  LYS THR GLY PRO GLU GLU ASP ASN LYS ALA CYS TYR PRO          
SEQRES   6 C  681  PRO LEU ILE VAL GLN PRO CYS SER GLU VAL LEU THR LEU          
SEQRES   7 C  681  THR ASN ASN VAL ASN LYS LEU LEU ILE ILE ASP TYR SER          
SEQRES   8 C  681  GLU ASN ARG LEU LEU ALA CYS GLY SER LEU TYR GLN GLY          
SEQRES   9 C  681  VAL CYS LYS LEU LEU ARG LEU ASP ASP LEU PHE ILE LEU          
SEQRES  10 C  681  VAL GLU PRO SER HIS LYS LYS GLU HIS TYR LEU SER SER          
SEQRES  11 C  681  VAL ASN LYS THR GLY THR MET TYR GLY VAL ILE VAL ARG          
SEQRES  12 C  681  SER GLU GLY GLU ASP GLY LYS LEU PHE ILE GLY THR ALA          
SEQRES  13 C  681  VAL ASP GLY LYS GLN ASP TYR PHE PRO THR LEU SER SER          
SEQRES  14 C  681  ARG LYS LEU PRO ARG ASP PRO GLU SER SER ALA MET LEU          
SEQRES  15 C  681  ASP TYR GLU LEU HIS SER ASP PHE VAL SER SER LEU ILE          
SEQRES  16 C  681  LYS ILE PRO SER ASP THR LEU ALA LEU VAL SER HIS PHE          
SEQRES  17 C  681  ASP ILE PHE TYR ILE TYR GLY PHE ALA SER GLY GLY PHE          
SEQRES  18 C  681  VAL TYR PHE LEU THR VAL GLN PRO GLU THR PRO ASP GLY          
SEQRES  19 C  681  MET ALA ILE ASN SER ALA GLY ASP LEU PHE TYR THR SER          
SEQRES  20 C  681  ARG ILE VAL ARG LEU CYS LYS ASP ASP PRO LYS PHE HIS          
SEQRES  21 C  681  SER TYR VAL SER LEU PRO PHE GLY CYS THR ARG ALA GLY          
SEQRES  22 C  681  VAL GLU TYR ARG LEU LEU GLN ALA ALA TYR LEU ALA LYS          
SEQRES  23 C  681  PRO GLY GLU ALA LEU ALA GLN ALA PHE ASN ILE SER SER          
SEQRES  24 C  681  ASP GLU ASP VAL LEU PHE ALA ILE PHE SER LYS GLY GLN          
SEQRES  25 C  681  LYS GLN TYR HIS HIS PRO PRO ASP ASP SER ALA LEU CYS          
SEQRES  26 C  681  ALA PHE PRO ILE ARG ALA ILE ASN LEU GLN ILE LYS GLU          
SEQRES  27 C  681  ARG LEU GLN SER CYS TYR HIS GLY GLU GLY ASN LEU GLU          
SEQRES  28 C  681  LEU ASN TRP LEU LEU GLY LYS ASP VAL GLN CYS THR LYS          
SEQRES  29 C  681  ALA PRO VAL PRO ILE ASP ASP ASN PHE CYS GLY LEU ASP          
SEQRES  30 C  681  ILE ASN GLN PRO LEU GLY GLY SER THR PRO VAL GLU GLY          
SEQRES  31 C  681  LEU THR LEU TYR THR THR SER ARG ASP ARG LEU THR SER          
SEQRES  32 C  681  VAL ALA SER TYR VAL TYR ASN GLY TYR SER VAL VAL PHE          
SEQRES  33 C  681  VAL GLY THR LYS SER GLY LYS LEU LYS LYS ILE ARG ALA          
SEQRES  34 C  681  ASP GLY PRO PRO HIS GLY GLY VAL GLN TYR GLU MET VAL          
SEQRES  35 C  681  SER VAL PHE LYS ASP GLY SER PRO ILE LEU ARG ASP MET          
SEQRES  36 C  681  ALA PHE SER ILE ASN GLN LEU TYR LEU TYR VAL MET SER          
SEQRES  37 C  681  GLU ARG GLN VAL THR ARG VAL PRO VAL GLU SER CYS GLU          
SEQRES  38 C  681  GLN TYR THR THR CYS GLY GLU CYS LEU SER SER GLY ASP          
SEQRES  39 C  681  PRO HIS CYS GLY TRP CYS ALA LEU HIS ASN MET CYS SER          
SEQRES  40 C  681  ARG ARG ASP LYS CYS GLN ARG ALA TRP GLU ALA ASN ARG          
SEQRES  41 C  681  PHE ALA ALA SER ILE SER GLN CYS MET SER LEU GLU VAL          
SEQRES  42 C  681  HIS PRO ASN SER ILE SER VAL SER ASP HIS SER ARG LEU          
SEQRES  43 C  681  LEU SER LEU VAL VAL ASN ASP ALA PRO ASN LEU SER GLU          
SEQRES  44 C  681  GLY ILE ALA CYS ALA PHE GLY ASN LEU THR GLU VAL GLU          
SEQRES  45 C  681  GLY GLN VAL SER GLY SER GLN VAL ILE CYS ILE SER PRO          
SEQRES  46 C  681  GLY PRO LYS ASP VAL PRO VAL ILE PRO LEU ASP GLN ASP          
SEQRES  47 C  681  TRP PHE GLY LEU GLU LEU GLN LEU ARG SER LYS GLU THR          
SEQRES  48 C  681  GLY LYS ILE PHE VAL SER THR GLU PHE LYS PHE TYR ASN          
SEQRES  49 C  681  CYS SER ALA HIS GLN LEU CYS LEU SER CYS VAL ASN SER          
SEQRES  50 C  681  ALA PHE ARG CYS HIS TRP CYS LYS TYR ARG ASN LEU CYS          
SEQRES  51 C  681  THR HIS ASP PRO THR THR CYS SER PHE GLN GLU GLY ARG          
SEQRES  52 C  681  ILE ASN VAL SER GLU ASP CYS PRO GLN GLY THR LYS HIS          
SEQRES  53 C  681  HIS HIS HIS HIS HIS                                          
SEQRES   1 D  681  GLU THR GLY MET PRO GLN TYR SER THR PHE HIS SER GLU          
SEQRES   2 D  681  ASN ARG ASP TRP THR PHE ASN HIS LEU THR VAL HIS ARG          
SEQRES   3 D  681  ARG THR GLY ALA VAL TYR VAL GLY ALA ILE ASN ARG VAL          
SEQRES   4 D  681  TYR LYS LEU THR GLY ASN LEU THR ILE GLN VAL ALA HIS          
SEQRES   5 D  681  LYS THR GLY PRO GLU GLU ASP ASN LYS ALA CYS TYR PRO          
SEQRES   6 D  681  PRO LEU ILE VAL GLN PRO CYS SER GLU VAL LEU THR LEU          
SEQRES   7 D  681  THR ASN ASN VAL ASN LYS LEU LEU ILE ILE ASP TYR SER          
SEQRES   8 D  681  GLU ASN ARG LEU LEU ALA CYS GLY SER LEU TYR GLN GLY          
SEQRES   9 D  681  VAL CYS LYS LEU LEU ARG LEU ASP ASP LEU PHE ILE LEU          
SEQRES  10 D  681  VAL GLU PRO SER HIS LYS LYS GLU HIS TYR LEU SER SER          
SEQRES  11 D  681  VAL ASN LYS THR GLY THR MET TYR GLY VAL ILE VAL ARG          
SEQRES  12 D  681  SER GLU GLY GLU ASP GLY LYS LEU PHE ILE GLY THR ALA          
SEQRES  13 D  681  VAL ASP GLY LYS GLN ASP TYR PHE PRO THR LEU SER SER          
SEQRES  14 D  681  ARG LYS LEU PRO ARG ASP PRO GLU SER SER ALA MET LEU          
SEQRES  15 D  681  ASP TYR GLU LEU HIS SER ASP PHE VAL SER SER LEU ILE          
SEQRES  16 D  681  LYS ILE PRO SER ASP THR LEU ALA LEU VAL SER HIS PHE          
SEQRES  17 D  681  ASP ILE PHE TYR ILE TYR GLY PHE ALA SER GLY GLY PHE          
SEQRES  18 D  681  VAL TYR PHE LEU THR VAL GLN PRO GLU THR PRO ASP GLY          
SEQRES  19 D  681  MET ALA ILE ASN SER ALA GLY ASP LEU PHE TYR THR SER          
SEQRES  20 D  681  ARG ILE VAL ARG LEU CYS LYS ASP ASP PRO LYS PHE HIS          
SEQRES  21 D  681  SER TYR VAL SER LEU PRO PHE GLY CYS THR ARG ALA GLY          
SEQRES  22 D  681  VAL GLU TYR ARG LEU LEU GLN ALA ALA TYR LEU ALA LYS          
SEQRES  23 D  681  PRO GLY GLU ALA LEU ALA GLN ALA PHE ASN ILE SER SER          
SEQRES  24 D  681  ASP GLU ASP VAL LEU PHE ALA ILE PHE SER LYS GLY GLN          
SEQRES  25 D  681  LYS GLN TYR HIS HIS PRO PRO ASP ASP SER ALA LEU CYS          
SEQRES  26 D  681  ALA PHE PRO ILE ARG ALA ILE ASN LEU GLN ILE LYS GLU          
SEQRES  27 D  681  ARG LEU GLN SER CYS TYR HIS GLY GLU GLY ASN LEU GLU          
SEQRES  28 D  681  LEU ASN TRP LEU LEU GLY LYS ASP VAL GLN CYS THR LYS          
SEQRES  29 D  681  ALA PRO VAL PRO ILE ASP ASP ASN PHE CYS GLY LEU ASP          
SEQRES  30 D  681  ILE ASN GLN PRO LEU GLY GLY SER THR PRO VAL GLU GLY          
SEQRES  31 D  681  LEU THR LEU TYR THR THR SER ARG ASP ARG LEU THR SER          
SEQRES  32 D  681  VAL ALA SER TYR VAL TYR ASN GLY TYR SER VAL VAL PHE          
SEQRES  33 D  681  VAL GLY THR LYS SER GLY LYS LEU LYS LYS ILE ARG ALA          
SEQRES  34 D  681  ASP GLY PRO PRO HIS GLY GLY VAL GLN TYR GLU MET VAL          
SEQRES  35 D  681  SER VAL PHE LYS ASP GLY SER PRO ILE LEU ARG ASP MET          
SEQRES  36 D  681  ALA PHE SER ILE ASN GLN LEU TYR LEU TYR VAL MET SER          
SEQRES  37 D  681  GLU ARG GLN VAL THR ARG VAL PRO VAL GLU SER CYS GLU          
SEQRES  38 D  681  GLN TYR THR THR CYS GLY GLU CYS LEU SER SER GLY ASP          
SEQRES  39 D  681  PRO HIS CYS GLY TRP CYS ALA LEU HIS ASN MET CYS SER          
SEQRES  40 D  681  ARG ARG ASP LYS CYS GLN ARG ALA TRP GLU ALA ASN ARG          
SEQRES  41 D  681  PHE ALA ALA SER ILE SER GLN CYS MET SER LEU GLU VAL          
SEQRES  42 D  681  HIS PRO ASN SER ILE SER VAL SER ASP HIS SER ARG LEU          
SEQRES  43 D  681  LEU SER LEU VAL VAL ASN ASP ALA PRO ASN LEU SER GLU          
SEQRES  44 D  681  GLY ILE ALA CYS ALA PHE GLY ASN LEU THR GLU VAL GLU          
SEQRES  45 D  681  GLY GLN VAL SER GLY SER GLN VAL ILE CYS ILE SER PRO          
SEQRES  46 D  681  GLY PRO LYS ASP VAL PRO VAL ILE PRO LEU ASP GLN ASP          
SEQRES  47 D  681  TRP PHE GLY LEU GLU LEU GLN LEU ARG SER LYS GLU THR          
SEQRES  48 D  681  GLY LYS ILE PHE VAL SER THR GLU PHE LYS PHE TYR ASN          
SEQRES  49 D  681  CYS SER ALA HIS GLN LEU CYS LEU SER CYS VAL ASN SER          
SEQRES  50 D  681  ALA PHE ARG CYS HIS TRP CYS LYS TYR ARG ASN LEU CYS          
SEQRES  51 D  681  THR HIS ASP PRO THR THR CYS SER PHE GLN GLU GLY ARG          
SEQRES  52 D  681  ILE ASN VAL SER GLU ASP CYS PRO GLN GLY THR LYS HIS          
SEQRES  53 D  681  HIS HIS HIS HIS HIS                                          
SEQRES   1 E  681  GLU THR GLY MET PRO GLN TYR SER THR PHE HIS SER GLU          
SEQRES   2 E  681  ASN ARG ASP TRP THR PHE ASN HIS LEU THR VAL HIS ARG          
SEQRES   3 E  681  ARG THR GLY ALA VAL TYR VAL GLY ALA ILE ASN ARG VAL          
SEQRES   4 E  681  TYR LYS LEU THR GLY ASN LEU THR ILE GLN VAL ALA HIS          
SEQRES   5 E  681  LYS THR GLY PRO GLU GLU ASP ASN LYS ALA CYS TYR PRO          
SEQRES   6 E  681  PRO LEU ILE VAL GLN PRO CYS SER GLU VAL LEU THR LEU          
SEQRES   7 E  681  THR ASN ASN VAL ASN LYS LEU LEU ILE ILE ASP TYR SER          
SEQRES   8 E  681  GLU ASN ARG LEU LEU ALA CYS GLY SER LEU TYR GLN GLY          
SEQRES   9 E  681  VAL CYS LYS LEU LEU ARG LEU ASP ASP LEU PHE ILE LEU          
SEQRES  10 E  681  VAL GLU PRO SER HIS LYS LYS GLU HIS TYR LEU SER SER          
SEQRES  11 E  681  VAL ASN LYS THR GLY THR MET TYR GLY VAL ILE VAL ARG          
SEQRES  12 E  681  SER GLU GLY GLU ASP GLY LYS LEU PHE ILE GLY THR ALA          
SEQRES  13 E  681  VAL ASP GLY LYS GLN ASP TYR PHE PRO THR LEU SER SER          
SEQRES  14 E  681  ARG LYS LEU PRO ARG ASP PRO GLU SER SER ALA MET LEU          
SEQRES  15 E  681  ASP TYR GLU LEU HIS SER ASP PHE VAL SER SER LEU ILE          
SEQRES  16 E  681  LYS ILE PRO SER ASP THR LEU ALA LEU VAL SER HIS PHE          
SEQRES  17 E  681  ASP ILE PHE TYR ILE TYR GLY PHE ALA SER GLY GLY PHE          
SEQRES  18 E  681  VAL TYR PHE LEU THR VAL GLN PRO GLU THR PRO ASP GLY          
SEQRES  19 E  681  MET ALA ILE ASN SER ALA GLY ASP LEU PHE TYR THR SER          
SEQRES  20 E  681  ARG ILE VAL ARG LEU CYS LYS ASP ASP PRO LYS PHE HIS          
SEQRES  21 E  681  SER TYR VAL SER LEU PRO PHE GLY CYS THR ARG ALA GLY          
SEQRES  22 E  681  VAL GLU TYR ARG LEU LEU GLN ALA ALA TYR LEU ALA LYS          
SEQRES  23 E  681  PRO GLY GLU ALA LEU ALA GLN ALA PHE ASN ILE SER SER          
SEQRES  24 E  681  ASP GLU ASP VAL LEU PHE ALA ILE PHE SER LYS GLY GLN          
SEQRES  25 E  681  LYS GLN TYR HIS HIS PRO PRO ASP ASP SER ALA LEU CYS          
SEQRES  26 E  681  ALA PHE PRO ILE ARG ALA ILE ASN LEU GLN ILE LYS GLU          
SEQRES  27 E  681  ARG LEU GLN SER CYS TYR HIS GLY GLU GLY ASN LEU GLU          
SEQRES  28 E  681  LEU ASN TRP LEU LEU GLY LYS ASP VAL GLN CYS THR LYS          
SEQRES  29 E  681  ALA PRO VAL PRO ILE ASP ASP ASN PHE CYS GLY LEU ASP          
SEQRES  30 E  681  ILE ASN GLN PRO LEU GLY GLY SER THR PRO VAL GLU GLY          
SEQRES  31 E  681  LEU THR LEU TYR THR THR SER ARG ASP ARG LEU THR SER          
SEQRES  32 E  681  VAL ALA SER TYR VAL TYR ASN GLY TYR SER VAL VAL PHE          
SEQRES  33 E  681  VAL GLY THR LYS SER GLY LYS LEU LYS LYS ILE ARG ALA          
SEQRES  34 E  681  ASP GLY PRO PRO HIS GLY GLY VAL GLN TYR GLU MET VAL          
SEQRES  35 E  681  SER VAL PHE LYS ASP GLY SER PRO ILE LEU ARG ASP MET          
SEQRES  36 E  681  ALA PHE SER ILE ASN GLN LEU TYR LEU TYR VAL MET SER          
SEQRES  37 E  681  GLU ARG GLN VAL THR ARG VAL PRO VAL GLU SER CYS GLU          
SEQRES  38 E  681  GLN TYR THR THR CYS GLY GLU CYS LEU SER SER GLY ASP          
SEQRES  39 E  681  PRO HIS CYS GLY TRP CYS ALA LEU HIS ASN MET CYS SER          
SEQRES  40 E  681  ARG ARG ASP LYS CYS GLN ARG ALA TRP GLU ALA ASN ARG          
SEQRES  41 E  681  PHE ALA ALA SER ILE SER GLN CYS MET SER LEU GLU VAL          
SEQRES  42 E  681  HIS PRO ASN SER ILE SER VAL SER ASP HIS SER ARG LEU          
SEQRES  43 E  681  LEU SER LEU VAL VAL ASN ASP ALA PRO ASN LEU SER GLU          
SEQRES  44 E  681  GLY ILE ALA CYS ALA PHE GLY ASN LEU THR GLU VAL GLU          
SEQRES  45 E  681  GLY GLN VAL SER GLY SER GLN VAL ILE CYS ILE SER PRO          
SEQRES  46 E  681  GLY PRO LYS ASP VAL PRO VAL ILE PRO LEU ASP GLN ASP          
SEQRES  47 E  681  TRP PHE GLY LEU GLU LEU GLN LEU ARG SER LYS GLU THR          
SEQRES  48 E  681  GLY LYS ILE PHE VAL SER THR GLU PHE LYS PHE TYR ASN          
SEQRES  49 E  681  CYS SER ALA HIS GLN LEU CYS LEU SER CYS VAL ASN SER          
SEQRES  50 E  681  ALA PHE ARG CYS HIS TRP CYS LYS TYR ARG ASN LEU CYS          
SEQRES  51 E  681  THR HIS ASP PRO THR THR CYS SER PHE GLN GLU GLY ARG          
SEQRES  52 E  681  ILE ASN VAL SER GLU ASP CYS PRO GLN GLY THR LYS HIS          
SEQRES  53 E  681  HIS HIS HIS HIS HIS                                          
SEQRES   1 F  681  GLU THR GLY MET PRO GLN TYR SER THR PHE HIS SER GLU          
SEQRES   2 F  681  ASN ARG ASP TRP THR PHE ASN HIS LEU THR VAL HIS ARG          
SEQRES   3 F  681  ARG THR GLY ALA VAL TYR VAL GLY ALA ILE ASN ARG VAL          
SEQRES   4 F  681  TYR LYS LEU THR GLY ASN LEU THR ILE GLN VAL ALA HIS          
SEQRES   5 F  681  LYS THR GLY PRO GLU GLU ASP ASN LYS ALA CYS TYR PRO          
SEQRES   6 F  681  PRO LEU ILE VAL GLN PRO CYS SER GLU VAL LEU THR LEU          
SEQRES   7 F  681  THR ASN ASN VAL ASN LYS LEU LEU ILE ILE ASP TYR SER          
SEQRES   8 F  681  GLU ASN ARG LEU LEU ALA CYS GLY SER LEU TYR GLN GLY          
SEQRES   9 F  681  VAL CYS LYS LEU LEU ARG LEU ASP ASP LEU PHE ILE LEU          
SEQRES  10 F  681  VAL GLU PRO SER HIS LYS LYS GLU HIS TYR LEU SER SER          
SEQRES  11 F  681  VAL ASN LYS THR GLY THR MET TYR GLY VAL ILE VAL ARG          
SEQRES  12 F  681  SER GLU GLY GLU ASP GLY LYS LEU PHE ILE GLY THR ALA          
SEQRES  13 F  681  VAL ASP GLY LYS GLN ASP TYR PHE PRO THR LEU SER SER          
SEQRES  14 F  681  ARG LYS LEU PRO ARG ASP PRO GLU SER SER ALA MET LEU          
SEQRES  15 F  681  ASP TYR GLU LEU HIS SER ASP PHE VAL SER SER LEU ILE          
SEQRES  16 F  681  LYS ILE PRO SER ASP THR LEU ALA LEU VAL SER HIS PHE          
SEQRES  17 F  681  ASP ILE PHE TYR ILE TYR GLY PHE ALA SER GLY GLY PHE          
SEQRES  18 F  681  VAL TYR PHE LEU THR VAL GLN PRO GLU THR PRO ASP GLY          
SEQRES  19 F  681  MET ALA ILE ASN SER ALA GLY ASP LEU PHE TYR THR SER          
SEQRES  20 F  681  ARG ILE VAL ARG LEU CYS LYS ASP ASP PRO LYS PHE HIS          
SEQRES  21 F  681  SER TYR VAL SER LEU PRO PHE GLY CYS THR ARG ALA GLY          
SEQRES  22 F  681  VAL GLU TYR ARG LEU LEU GLN ALA ALA TYR LEU ALA LYS          
SEQRES  23 F  681  PRO GLY GLU ALA LEU ALA GLN ALA PHE ASN ILE SER SER          
SEQRES  24 F  681  ASP GLU ASP VAL LEU PHE ALA ILE PHE SER LYS GLY GLN          
SEQRES  25 F  681  LYS GLN TYR HIS HIS PRO PRO ASP ASP SER ALA LEU CYS          
SEQRES  26 F  681  ALA PHE PRO ILE ARG ALA ILE ASN LEU GLN ILE LYS GLU          
SEQRES  27 F  681  ARG LEU GLN SER CYS TYR HIS GLY GLU GLY ASN LEU GLU          
SEQRES  28 F  681  LEU ASN TRP LEU LEU GLY LYS ASP VAL GLN CYS THR LYS          
SEQRES  29 F  681  ALA PRO VAL PRO ILE ASP ASP ASN PHE CYS GLY LEU ASP          
SEQRES  30 F  681  ILE ASN GLN PRO LEU GLY GLY SER THR PRO VAL GLU GLY          
SEQRES  31 F  681  LEU THR LEU TYR THR THR SER ARG ASP ARG LEU THR SER          
SEQRES  32 F  681  VAL ALA SER TYR VAL TYR ASN GLY TYR SER VAL VAL PHE          
SEQRES  33 F  681  VAL GLY THR LYS SER GLY LYS LEU LYS LYS ILE ARG ALA          
SEQRES  34 F  681  ASP GLY PRO PRO HIS GLY GLY VAL GLN TYR GLU MET VAL          
SEQRES  35 F  681  SER VAL PHE LYS ASP GLY SER PRO ILE LEU ARG ASP MET          
SEQRES  36 F  681  ALA PHE SER ILE ASN GLN LEU TYR LEU TYR VAL MET SER          
SEQRES  37 F  681  GLU ARG GLN VAL THR ARG VAL PRO VAL GLU SER CYS GLU          
SEQRES  38 F  681  GLN TYR THR THR CYS GLY GLU CYS LEU SER SER GLY ASP          
SEQRES  39 F  681  PRO HIS CYS GLY TRP CYS ALA LEU HIS ASN MET CYS SER          
SEQRES  40 F  681  ARG ARG ASP LYS CYS GLN ARG ALA TRP GLU ALA ASN ARG          
SEQRES  41 F  681  PHE ALA ALA SER ILE SER GLN CYS MET SER LEU GLU VAL          
SEQRES  42 F  681  HIS PRO ASN SER ILE SER VAL SER ASP HIS SER ARG LEU          
SEQRES  43 F  681  LEU SER LEU VAL VAL ASN ASP ALA PRO ASN LEU SER GLU          
SEQRES  44 F  681  GLY ILE ALA CYS ALA PHE GLY ASN LEU THR GLU VAL GLU          
SEQRES  45 F  681  GLY GLN VAL SER GLY SER GLN VAL ILE CYS ILE SER PRO          
SEQRES  46 F  681  GLY PRO LYS ASP VAL PRO VAL ILE PRO LEU ASP GLN ASP          
SEQRES  47 F  681  TRP PHE GLY LEU GLU LEU GLN LEU ARG SER LYS GLU THR          
SEQRES  48 F  681  GLY LYS ILE PHE VAL SER THR GLU PHE LYS PHE TYR ASN          
SEQRES  49 F  681  CYS SER ALA HIS GLN LEU CYS LEU SER CYS VAL ASN SER          
SEQRES  50 F  681  ALA PHE ARG CYS HIS TRP CYS LYS TYR ARG ASN LEU CYS          
SEQRES  51 F  681  THR HIS ASP PRO THR THR CYS SER PHE GLN GLU GLY ARG          
SEQRES  52 F  681  ILE ASN VAL SER GLU ASP CYS PRO GLN GLY THR LYS HIS          
SEQRES  53 F  681  HIS HIS HIS HIS HIS                                          
SEQRES   1 G  538  GLU THR GLY ASN TYR ALA ASN GLY LYS ASN ASN VAL PRO          
SEQRES   2 G  538  ARG LEU LYS LEU SER TYR LYS GLU MET LEU GLU SER ASN          
SEQRES   3 G  538  ASN VAL ILE THR PHE ASN GLY LEU ALA ASN SER SER SER          
SEQRES   4 G  538  TYR HIS THR PHE LEU LEU ASP GLU GLU ARG SER ARG LEU          
SEQRES   5 G  538  TYR VAL GLY ALA LYS ASP HIS ILE PHE SER PHE ASN LEU          
SEQRES   6 G  538  VAL ASN ILE LYS ASP PHE GLN LYS ILE VAL TRP PRO VAL          
SEQRES   7 G  538  SER TYR THR ARG ARG ASP GLU CYS LYS TRP ALA GLY LYS          
SEQRES   8 G  538  ASP ILE LEU LYS GLU CYS ALA ASN PHE ILE LYS VAL LEU          
SEQRES   9 G  538  GLU ALA TYR ASN GLN THR HIS LEU TYR ALA CYS GLY THR          
SEQRES  10 G  538  GLY ALA PHE HIS PRO ILE CYS THR TYR ILE GLU VAL GLY          
SEQRES  11 G  538  HIS HIS PRO GLU ASP ASN ILE PHE LYS LEU GLN ASP SER          
SEQRES  12 G  538  HIS PHE GLU ASN GLY ARG GLY LYS SER PRO TYR ASP PRO          
SEQRES  13 G  538  LYS LEU LEU THR ALA SER LEU LEU ILE ASP GLY GLU LEU          
SEQRES  14 G  538  TYR SER GLY THR ALA ALA ASP PHE MET GLY ARG ASP PHE          
SEQRES  15 G  538  ALA ILE PHE ARG THR LEU GLY HIS HIS HIS PRO ILE ARG          
SEQRES  16 G  538  THR GLU GLN HIS ASP SER ARG TRP LEU ASN ASP PRO ARG          
SEQRES  17 G  538  PHE ILE SER ALA HIS LEU ILE PRO GLU SER ASP ASN PRO          
SEQRES  18 G  538  GLU ASP ASP LYS VAL TYR PHE PHE PHE ARG GLU ASN ALA          
SEQRES  19 G  538  ILE ASP GLY GLU HIS SER GLY LYS ALA THR HIS ALA ARG          
SEQRES  20 G  538  ILE GLY GLN ILE CYS LYS ASN ASP PHE GLY GLY HIS ARG          
SEQRES  21 G  538  SER LEU VAL ASN LYS TRP THR THR PHE LEU LYS ALA ARG          
SEQRES  22 G  538  LEU ILE CYS SER VAL PRO GLY PRO ASN GLY ILE ASP THR          
SEQRES  23 G  538  HIS PHE ASP GLU LEU GLN ASP VAL PHE LEU MET ASN SER          
SEQRES  24 G  538  LYS ASP PRO LYS ASN PRO ILE VAL TYR GLY VAL PHE THR          
SEQRES  25 G  538  THR SER SER ASN ILE PHE LYS GLY SER ALA VAL CYS MET          
SEQRES  26 G  538  TYR SER MET SER ASP VAL ARG ARG VAL PHE LEU GLY PRO          
SEQRES  27 G  538  TYR ALA HIS ARG ASP GLY PRO ASN TYR GLN TRP VAL PRO          
SEQRES  28 G  538  TYR GLN GLY ARG VAL PRO TYR PRO ARG PRO GLY THR CYS          
SEQRES  29 G  538  PRO SER LYS THR PHE GLY GLY PHE ASP SER THR LYS ASP          
SEQRES  30 G  538  LEU PRO ASP ASP VAL ILE THR PHE ALA ARG SER HIS PRO          
SEQRES  31 G  538  ALA MET TYR ASN PRO VAL PHE PRO ILE ASN ASN ARG PRO          
SEQRES  32 G  538  ILE MET ILE LYS THR ASP VAL ASN TYR GLN PHE THR GLN          
SEQRES  33 G  538  ILE VAL VAL ASP ARG VAL ASP ALA GLU ASP GLY GLN TYR          
SEQRES  34 G  538  ASP VAL MET PHE ILE GLY THR ASP VAL GLY THR VAL LEU          
SEQRES  35 G  538  LYS VAL VAL SER VAL PRO LYS GLU THR TRP HIS ASP LEU          
SEQRES  36 G  538  GLU GLU VAL LEU LEU GLU GLU MET THR VAL PHE ARG GLU          
SEQRES  37 G  538  PRO THR THR ILE SER ALA MET GLU LEU SER THR LYS GLN          
SEQRES  38 G  538  GLN GLN LEU TYR ILE GLY SER THR ALA GLY VAL ALA GLN          
SEQRES  39 G  538  LEU PRO LEU HIS ARG CYS ASP ILE TYR GLY LYS ALA CYS          
SEQRES  40 G  538  ALA GLU CYS CYS LEU ALA ARG ASP PRO TYR CYS ALA TRP          
SEQRES  41 G  538  ASP GLY SER SER CYS SER ARG TYR PHE PRO THR ALA LYS          
SEQRES  42 G  538  ARG ARG THR ARG ARG                                          
SEQRES   1 H  577  GLU THR GLY PHE ARG SER ASP LYS CYS GLY GLY THR ILE          
SEQRES   2 H  577  LYS ILE GLU ASN PRO GLY TYR LEU THR SER PRO GLY TYR          
SEQRES   3 H  577  PRO HIS SER TYR HIS PRO SER GLU LYS CYS GLU TRP LEU          
SEQRES   4 H  577  ILE GLN ALA PRO GLU PRO TYR GLN ARG ILE MET ILE ASN          
SEQRES   5 H  577  PHE ASN PRO HIS PHE ASP LEU GLU ASP ARG ASP CYS LYS          
SEQRES   6 H  577  TYR ASP TYR VAL GLU VAL ILE ASP GLY GLU ASN GLU GLY          
SEQRES   7 H  577  GLY ARG LEU TRP GLY LYS PHE CYS GLY LYS ILE ALA PRO          
SEQRES   8 H  577  SER PRO VAL VAL SER SER GLY PRO PHE LEU PHE ILE LYS          
SEQRES   9 H  577  PHE VAL SER ASP TYR GLU THR HIS GLY ALA GLY PHE SER          
SEQRES  10 H  577  ILE ARG TYR GLU ILE PHE LYS ARG GLY PRO GLU CYS SER          
SEQRES  11 H  577  GLN ASN TYR THR ALA PRO THR GLY VAL ILE LYS SER PRO          
SEQRES  12 H  577  GLY PHE PRO GLU LYS TYR PRO ASN SER LEU GLU CYS THR          
SEQRES  13 H  577  TYR ILE ILE PHE ALA PRO LYS MET SER GLU ILE ILE LEU          
SEQRES  14 H  577  GLU PHE GLU SER PHE ASP LEU GLU GLN ASP SER ASN PRO          
SEQRES  15 H  577  PRO GLY GLY MET PHE CYS ARG TYR ASP ARG LEU GLU ILE          
SEQRES  16 H  577  TRP ASP GLY PHE PRO GLU VAL GLY PRO HIS ILE GLY ARG          
SEQRES  17 H  577  TYR CYS GLY GLN LYS THR PRO GLY ARG ILE ARG SER SER          
SEQRES  18 H  577  SER GLY VAL LEU SER MET VAL PHE TYR THR ASP SER ALA          
SEQRES  19 H  577  ILE ALA LYS GLU GLY PHE SER ALA ASN TYR SER VAL LEU          
SEQRES  20 H  577  GLN SER SER ILE SER GLU ASP PHE LYS CYS MET GLU ALA          
SEQRES  21 H  577  LEU GLY MET GLU SER GLY GLU ILE HIS SER ASP GLN ILE          
SEQRES  22 H  577  THR ALA SER SER GLN TYR GLY THR ASN TRP SER VAL GLU          
SEQRES  23 H  577  ARG SER ARG LEU ASN TYR PRO GLU ASN GLY TRP THR PRO          
SEQRES  24 H  577  GLY GLU ASP SER TYR LYS GLU TRP ILE GLN VAL ASP LEU          
SEQRES  25 H  577  GLY LEU LEU ARG PHE VAL THR ALA VAL GLY THR GLN GLY          
SEQRES  26 H  577  ALA ILE SER LYS GLU THR LYS LYS LYS TYR TYR VAL LYS          
SEQRES  27 H  577  THR TYR ARG VAL ASP ILE SER SER ASN GLY GLU ASP TRP          
SEQRES  28 H  577  ILE SER LEU LYS GLU GLY ASN LYS ALA ILE ILE PHE GLN          
SEQRES  29 H  577  GLY ASN THR ASN PRO THR ASP VAL VAL LEU GLY VAL PHE          
SEQRES  30 H  577  SER LYS PRO LEU ILE THR ARG PHE VAL ARG ILE LYS PRO          
SEQRES  31 H  577  VAL SER TRP GLU THR GLY ILE SER MET ARG PHE GLU VAL          
SEQRES  32 H  577  TYR GLY CYS LYS ILE THR ASP TYR PRO CYS SER GLY MET          
SEQRES  33 H  577  LEU GLY MET VAL SER GLY LEU ILE SER ASP SER GLN ILE          
SEQRES  34 H  577  THR ALA SER ASN GLN ALA ASP ARG ASN TRP MET PRO GLU          
SEQRES  35 H  577  ASN ILE ARG LEU VAL THR SER ARG THR GLY TRP ALA LEU          
SEQRES  36 H  577  PRO PRO SER PRO HIS PRO TYR THR ASN GLU TRP LEU GLN          
SEQRES  37 H  577  VAL ASP LEU GLY ASP GLU LYS ILE VAL ARG GLY VAL ILE          
SEQRES  38 H  577  ILE GLN GLY GLY LYS HIS ARG GLU ASN LYS VAL PHE MET          
SEQRES  39 H  577  ARG LYS PHE LYS ILE ALA TYR SER ASN ASN GLY SER ASP          
SEQRES  40 H  577  TRP LYS THR ILE MET ASP ASP SER LYS ARG LYS ALA LYS          
SEQRES  41 H  577  SER PHE GLU GLY ASN ASN ASN TYR ASP THR PRO GLU LEU          
SEQRES  42 H  577  ARG THR PHE SER PRO LEU SER THR ARG PHE ILE ARG ILE          
SEQRES  43 H  577  TYR PRO GLU ARG ALA THR HIS SER GLY LEU GLY LEU ARG          
SEQRES  44 H  577  MET GLU LEU LEU GLY CYS GLU VAL GLU ARG THR LYS HIS          
SEQRES  45 H  577  HIS HIS HIS HIS HIS                                          
HET     CA  H 601       1                                                       
HETNAM      CA CALCIUM ION                                                      
FORMUL   9   CA    CA 2+                                                        
HELIX    1   1 TYR A  121  GLU A  123  5                                   3    
HELIX    2   2 LEU A  132  GLY A  135  5                                   4    
HELIX    3   3 LYS A  154  TYR A  158  5                                   5    
HELIX    4   4 PRO A  229  VAL A  236  1                                   8    
HELIX    5   5 GLY A  319  ASN A  327  1                                   9    
HELIX    6   6 ILE A  360  TYR A  375  1                                  16    
HELIX    7   7 LEU A  383  GLY A  388  1                                   6    
HELIX    8   8 SER A  510  TYR A  514  5                                   5    
HELIX    9   9 THR A  516  LEU A  521  1                                   6    
HELIX   10  10 ARG A  539  CYS A  543  5                                   5    
HELIX   11  11 SER A  555  CYS A  559  5                                   5    
HELIX   12  12 CYS A  656  HIS A  659  5                                   4    
HELIX   13  13 LEU A  661  ASN A  667  1                                   7    
HELIX   14  14 ASP A  684  CYS A  688  5                                   5    
HELIX   15  15 PHE A  690  GLU A  692  5                                   3    
HELIX   16  16 VAL A  697  CYS A  701  5                                   5    
HELIX   17  17 TYR B  121  GLU B  123  5                                   3    
HELIX   18  18 LEU B  132  GLY B  135  5                                   4    
HELIX   19  19 LYS B  154  TYR B  158  5                                   5    
HELIX   20  20 PRO B  229  VAL B  236  1                                   8    
HELIX   21  21 GLY B  319  ASN B  327  1                                   9    
HELIX   22  22 ILE B  360  TYR B  375  1                                  16    
HELIX   23  23 LEU B  383  GLY B  388  1                                   6    
HELIX   24  24 SER B  510  TYR B  514  5                                   5    
HELIX   25  25 THR B  516  LEU B  521  1                                   6    
HELIX   26  26 ARG B  539  CYS B  543  5                                   5    
HELIX   27  27 SER B  555  CYS B  559  5                                   5    
HELIX   28  28 CYS B  656  HIS B  659  5                                   4    
HELIX   29  29 LEU B  661  ASN B  667  1                                   7    
HELIX   30  30 ASP B  684  CYS B  688  5                                   5    
HELIX   31  31 PHE B  690  GLU B  692  5                                   3    
HELIX   32  32 VAL B  697  CYS B  701  5                                   5    
HELIX   33  33 TYR C  121  GLU C  123  5                                   3    
HELIX   34  34 LEU C  132  GLY C  135  5                                   4    
HELIX   35  35 LYS C  154  TYR C  158  5                                   5    
HELIX   36  36 PRO C  229  VAL C  236  1                                   8    
HELIX   37  37 GLY C  319  ASN C  327  1                                   9    
HELIX   38  38 ILE C  360  TYR C  375  1                                  16    
HELIX   39  39 LEU C  383  GLY C  388  1                                   6    
HELIX   40  40 SER C  510  TYR C  514  5                                   5    
HELIX   41  41 THR C  516  LEU C  521  1                                   6    
HELIX   42  42 ARG C  539  CYS C  543  5                                   5    
HELIX   43  43 SER C  555  CYS C  559  5                                   5    
HELIX   44  44 CYS C  656  HIS C  659  5                                   4    
HELIX   45  45 LEU C  661  ASN C  667  1                                   7    
HELIX   46  46 ASP C  684  CYS C  688  5                                   5    
HELIX   47  47 PHE C  690  GLU C  692  5                                   3    
HELIX   48  48 VAL C  697  CYS C  701  5                                   5    
HELIX   49  49 TYR D  121  GLU D  123  5                                   3    
HELIX   50  50 LEU D  132  GLY D  135  5                                   4    
HELIX   51  51 LYS D  154  TYR D  158  5                                   5    
HELIX   52  52 PRO D  229  VAL D  236  1                                   8    
HELIX   53  53 GLY D  319  ASN D  327  1                                   9    
HELIX   54  54 ILE D  360  TYR D  375  1                                  16    
HELIX   55  55 LEU D  383  GLY D  388  1                                   6    
HELIX   56  56 SER D  510  TYR D  514  5                                   5    
HELIX   57  57 THR D  516  LEU D  521  1                                   6    
HELIX   58  58 ARG D  539  CYS D  543  5                                   5    
HELIX   59  59 SER D  555  CYS D  559  5                                   5    
HELIX   60  60 CYS D  656  HIS D  659  5                                   4    
HELIX   61  61 LEU D  661  ASN D  667  1                                   7    
HELIX   62  62 ASP D  684  CYS D  688  5                                   5    
HELIX   63  63 PHE D  690  GLU D  692  5                                   3    
HELIX   64  64 VAL D  697  CYS D  701  5                                   5    
HELIX   65  65 TYR E  121  GLU E  123  5                                   3    
HELIX   66  66 LEU E  132  GLY E  135  5                                   4    
HELIX   67  67 LYS E  154  TYR E  158  5                                   5    
HELIX   68  68 PRO E  229  VAL E  236  1                                   8    
HELIX   69  69 GLY E  319  ASN E  327  1                                   9    
HELIX   70  70 ILE E  360  TYR E  375  1                                  16    
HELIX   71  71 LEU E  383  GLY E  388  1                                   6    
HELIX   72  72 SER E  510  TYR E  514  5                                   5    
HELIX   73  73 THR E  516  LEU E  521  1                                   6    
HELIX   74  74 ARG E  539  CYS E  543  5                                   5    
HELIX   75  75 SER E  555  CYS E  559  5                                   5    
HELIX   76  76 CYS E  656  HIS E  659  5                                   4    
HELIX   77  77 LEU E  661  ASN E  667  1                                   7    
HELIX   78  78 ASP E  684  CYS E  688  5                                   5    
HELIX   79  79 PHE E  690  GLU E  692  5                                   3    
HELIX   80  80 VAL E  697  CYS E  701  5                                   5    
HELIX   81  81 TYR F  121  GLU F  123  5                                   3    
HELIX   82  82 LEU F  132  GLY F  135  5                                   4    
HELIX   83  83 LYS F  154  TYR F  158  5                                   5    
HELIX   84  84 PRO F  229  VAL F  236  1                                   8    
HELIX   85  85 GLY F  319  ASN F  327  1                                   9    
HELIX   86  86 ILE F  360  TYR F  375  1                                  16    
HELIX   87  87 LEU F  383  GLY F  388  1                                   6    
HELIX   88  88 SER F  510  TYR F  514  5                                   5    
HELIX   89  89 THR F  516  LEU F  521  1                                   6    
HELIX   90  90 ARG F  539  CYS F  543  5                                   5    
HELIX   91  91 SER F  555  CYS F  559  5                                   5    
HELIX   92  92 CYS F  656  HIS F  659  5                                   4    
HELIX   93  93 LEU F  661  ASN F  667  1                                   7    
HELIX   94  94 ASP F  684  CYS F  688  5                                   5    
HELIX   95  95 PHE F  690  GLU F  692  5                                   3    
HELIX   96  96 VAL F  697  CYS F  701  5                                   5    
HELIX   97  97 SER G   35  GLU G   41  1                                   7    
HELIX   98  98 SER G   96  ALA G  106  1                                  11    
HELIX   99  99 ASN G  237  ASP G  240  5                                   4    
HELIX  100 100 SER G  344  LEU G  353  1                                  10    
HELIX  101 101 SER G  391  LEU G  395  5                                   5    
HELIX  102 102 PRO G  396  SER G  405  1                                  10    
HELIX  103 103 PRO G  415  ARG G  419  5                                   5    
HELIX  104 104 ASP H   79  LYS H   83  5                                   5    
SHEET    1   A 4 THR A  40  HIS A  42  0                                        
SHEET    2   A 4 GLN A 502  PRO A 507 -1  O  VAL A 503   N  PHE A  41           
SHEET    3   A 4 TYR A 494  MET A 498 -1  N  VAL A 497   O  THR A 504           
SHEET    4   A 4 ALA A 487  PHE A 488 -1  N  ALA A 487   O  TYR A 496           
SHEET    1   B 4 PHE A  50  VAL A  55  0                                        
SHEET    2   B 4 VAL A  62  ALA A  66 -1  O  TYR A  63   N  THR A  54           
SHEET    3   B 4 ARG A  69  LEU A  73 -1  O  LEU A  73   N  VAL A  62           
SHEET    4   B 4 ILE A  79  LYS A  84 -1  O  GLN A  80   N  LYS A  72           
SHEET    1   C 2 GLU A  88  ASP A  90  0                                        
SHEET    2   C 2 THR A 108  THR A 110 -1  O  THR A 108   N  ASP A  90           
SHEET    1   D 4 ASN A 114  ASP A 120  0                                        
SHEET    2   D 4 ARG A 125  GLY A 130 -1  O  LEU A 127   N  ILE A 118           
SHEET    3   D 4 CYS A 137  ARG A 141 -1  O  LEU A 140   N  LEU A 126           
SHEET    4   D 4 ILE A 147  VAL A 149 -1  O  LEU A 148   N  LEU A 139           
SHEET    1   E 4 MET A 168  VAL A 173  0                                        
SHEET    2   E 4 LYS A 181  THR A 186 -1  O  PHE A 183   N  VAL A 171           
SHEET    3   E 4 LEU A 198  LYS A 202 -1  O  ARG A 201   N  LEU A 182           
SHEET    4   E 4 LEU A 225  ILE A 226 -1  O  ILE A 226   N  LEU A 198           
SHEET    1   F 5 PHE A 242  SER A 249  0                                        
SHEET    2   F 5 PHE A 252  PRO A 260 -1  O  VAL A 258   N  PHE A 242           
SHEET    3   F 5 TYR A 276  CYS A 284 -1  O  THR A 277   N  GLN A 259           
SHEET    4   F 5 VAL A 294  ARG A 302 -1  O  LEU A 296   N  ILE A 280           
SHEET    5   F 5 VAL A 419  GLU A 420  1  O  VAL A 419   N  PRO A 297           
SHEET    1   G 8 PHE A 242  SER A 249  0                                        
SHEET    2   G 8 PHE A 252  PRO A 260 -1  O  VAL A 258   N  PHE A 242           
SHEET    3   G 8 TYR A 276  CYS A 284 -1  O  THR A 277   N  GLN A 259           
SHEET    4   G 8 VAL A 294  ARG A 302 -1  O  LEU A 296   N  ILE A 280           
SHEET    5   G 8 VAL A 305  ALA A 316 -1  O  TYR A 307   N  CYS A 300           
SHEET    6   G 8 VAL A 334  LYS A 341 -1  O  VAL A 334   N  ALA A 316           
SHEET    7   G 8 SER A 353  PRO A 359 -1  O  PHE A 358   N  LEU A 335           
SHEET    8   G 8 LEU A 422  THR A 427 -1  O  LEU A 424   N  LEU A 355           
SHEET    1   H 4 LEU A 432  TYR A 440  0                                        
SHEET    2   H 4 TYR A 443  THR A 450 -1  O  PHE A 447   N  ALA A 436           
SHEET    3   H 4 LYS A 454  ALA A 460 -1  O  ILE A 458   N  VAL A 446           
SHEET    4   H 4 GLY A 467  SER A 474 -1  O  VAL A 468   N  ARG A 459           
SHEET    1   I 3 MET A 536  SER A 538  0                                        
SHEET    2   I 3 GLY A 529  CYS A 531 -1  N  CYS A 531   O  MET A 536           
SHEET    3   I 3 PHE A 552  ALA A 553 -1  O  ALA A 553   N  TRP A 530           
SHEET    1   J 4 SER A 561  HIS A 565  0                                        
SHEET    2   J 4 LEU A 577  ASN A 583 -1  O  VAL A 581   N  GLU A 563           
SHEET    3   J 4 GLN A 610  ILE A 614 -1  O  VAL A 611   N  LEU A 580           
SHEET    4   J 4 GLN A 605  SER A 607 -1  N  SER A 607   O  GLN A 610           
SHEET    1   K 5 SER A 568  SER A 570  0                                        
SHEET    2   K 5 ILE A 645  TYR A 654  1  O  TYR A 654   N  ILE A 569           
SHEET    3   K 5 TRP A 630  SER A 639 -1  N  LEU A 633   O  PHE A 651           
SHEET    4   K 5 ILE A 592  PHE A 596 -1  N  ALA A 595   O  GLN A 636           
SHEET    5   K 5 THR A 600  GLU A 603 -1  O  VAL A 602   N  CYS A 594           
SHEET    1   L 3 LEU A 680  THR A 682  0                                        
SHEET    2   L 3 HIS A 673  CYS A 675 -1  N  HIS A 673   O  THR A 682           
SHEET    3   L 3 ARG A 694  ILE A 695 -1  O  ILE A 695   N  TRP A 674           
SHEET    1   M 4 THR B  40  HIS B  42  0                                        
SHEET    2   M 4 GLN B 502  PRO B 507 -1  O  VAL B 503   N  PHE B  41           
SHEET    3   M 4 TYR B 494  MET B 498 -1  N  VAL B 497   O  THR B 504           
SHEET    4   M 4 ALA B 487  PHE B 488 -1  N  ALA B 487   O  TYR B 496           
SHEET    1   N 4 PHE B  50  VAL B  55  0                                        
SHEET    2   N 4 VAL B  62  ALA B  66 -1  O  TYR B  63   N  THR B  54           
SHEET    3   N 4 ARG B  69  LEU B  73 -1  O  LEU B  73   N  VAL B  62           
SHEET    4   N 4 ILE B  79  LYS B  84 -1  O  GLN B  80   N  LYS B  72           
SHEET    1   O 2 GLU B  88  ASP B  90  0                                        
SHEET    2   O 2 THR B 108  THR B 110 -1  O  THR B 108   N  ASP B  90           
SHEET    1   P 4 ASN B 114  ASP B 120  0                                        
SHEET    2   P 4 ARG B 125  GLY B 130 -1  O  LEU B 127   N  ILE B 118           
SHEET    3   P 4 CYS B 137  ARG B 141 -1  O  LEU B 140   N  LEU B 126           
SHEET    4   P 4 ILE B 147  VAL B 149 -1  O  LEU B 148   N  LEU B 139           
SHEET    1   Q 4 MET B 168  VAL B 173  0                                        
SHEET    2   Q 4 LYS B 181  THR B 186 -1  O  PHE B 183   N  VAL B 171           
SHEET    3   Q 4 LEU B 198  LYS B 202 -1  O  ARG B 201   N  LEU B 182           
SHEET    4   Q 4 LEU B 225  ILE B 226 -1  O  ILE B 226   N  LEU B 198           
SHEET    1   R 5 PHE B 242  SER B 249  0                                        
SHEET    2   R 5 PHE B 252  PRO B 260 -1  O  VAL B 258   N  PHE B 242           
SHEET    3   R 5 TYR B 276  CYS B 284 -1  O  THR B 277   N  GLN B 259           
SHEET    4   R 5 VAL B 294  ARG B 302 -1  O  LEU B 296   N  ILE B 280           
SHEET    5   R 5 VAL B 419  GLU B 420  1  O  VAL B 419   N  PRO B 297           
SHEET    1   S 8 PHE B 242  SER B 249  0                                        
SHEET    2   S 8 PHE B 252  PRO B 260 -1  O  VAL B 258   N  PHE B 242           
SHEET    3   S 8 TYR B 276  CYS B 284 -1  O  THR B 277   N  GLN B 259           
SHEET    4   S 8 VAL B 294  ARG B 302 -1  O  LEU B 296   N  ILE B 280           
SHEET    5   S 8 VAL B 305  ALA B 316 -1  O  TYR B 307   N  CYS B 300           
SHEET    6   S 8 VAL B 334  LYS B 341 -1  O  VAL B 334   N  ALA B 316           
SHEET    7   S 8 SER B 353  PRO B 359 -1  O  PHE B 358   N  LEU B 335           
SHEET    8   S 8 LEU B 422  THR B 427 -1  O  LEU B 424   N  LEU B 355           
SHEET    1   T 4 LEU B 432  TYR B 440  0                                        
SHEET    2   T 4 TYR B 443  THR B 450 -1  O  PHE B 447   N  ALA B 436           
SHEET    3   T 4 LYS B 454  ALA B 460 -1  O  ILE B 458   N  VAL B 446           
SHEET    4   T 4 GLY B 467  SER B 474 -1  O  VAL B 468   N  ARG B 459           
SHEET    1   U 3 MET B 536  SER B 538  0                                        
SHEET    2   U 3 GLY B 529  CYS B 531 -1  N  CYS B 531   O  MET B 536           
SHEET    3   U 3 PHE B 552  ALA B 553 -1  O  ALA B 553   N  TRP B 530           
SHEET    1   V 4 SER B 561  HIS B 565  0                                        
SHEET    2   V 4 LEU B 577  ASN B 583 -1  O  VAL B 581   N  GLU B 563           
SHEET    3   V 4 GLN B 610  ILE B 614 -1  O  VAL B 611   N  LEU B 580           
SHEET    4   V 4 GLN B 605  SER B 607 -1  N  SER B 607   O  GLN B 610           
SHEET    1   W 5 SER B 568  SER B 570  0                                        
SHEET    2   W 5 ILE B 645  TYR B 654  1  O  TYR B 654   N  ILE B 569           
SHEET    3   W 5 TRP B 630  SER B 639 -1  N  LEU B 633   O  PHE B 651           
SHEET    4   W 5 ILE B 592  PHE B 596 -1  N  ALA B 595   O  GLN B 636           
SHEET    5   W 5 THR B 600  GLU B 603 -1  O  VAL B 602   N  CYS B 594           
SHEET    1   X 3 LEU B 680  THR B 682  0                                        
SHEET    2   X 3 HIS B 673  CYS B 675 -1  N  HIS B 673   O  THR B 682           
SHEET    3   X 3 ARG B 694  ILE B 695 -1  O  ILE B 695   N  TRP B 674           
SHEET    1   Y 4 THR C  40  HIS C  42  0                                        
SHEET    2   Y 4 GLN C 502  PRO C 507 -1  O  VAL C 503   N  PHE C  41           
SHEET    3   Y 4 TYR C 494  MET C 498 -1  N  VAL C 497   O  THR C 504           
SHEET    4   Y 4 ALA C 487  PHE C 488 -1  N  ALA C 487   O  TYR C 496           
SHEET    1   Z 4 PHE C  50  VAL C  55  0                                        
SHEET    2   Z 4 VAL C  62  ALA C  66 -1  O  TYR C  63   N  THR C  54           
SHEET    3   Z 4 ARG C  69  LEU C  73 -1  O  LEU C  73   N  VAL C  62           
SHEET    4   Z 4 ILE C  79  LYS C  84 -1  O  GLN C  80   N  LYS C  72           
SHEET    1  AA 2 GLU C  88  ASP C  90  0                                        
SHEET    2  AA 2 THR C 108  THR C 110 -1  O  THR C 108   N  ASP C  90           
SHEET    1  AB 4 ASN C 114  ASP C 120  0                                        
SHEET    2  AB 4 ARG C 125  GLY C 130 -1  O  LEU C 127   N  ILE C 118           
SHEET    3  AB 4 CYS C 137  ARG C 141 -1  O  LEU C 140   N  LEU C 126           
SHEET    4  AB 4 ILE C 147  VAL C 149 -1  O  LEU C 148   N  LEU C 139           
SHEET    1  AC 4 MET C 168  VAL C 173  0                                        
SHEET    2  AC 4 LYS C 181  THR C 186 -1  O  PHE C 183   N  VAL C 171           
SHEET    3  AC 4 LEU C 198  LYS C 202 -1  O  ARG C 201   N  LEU C 182           
SHEET    4  AC 4 LEU C 225  ILE C 226 -1  O  ILE C 226   N  LEU C 198           
SHEET    1  AD 5 PHE C 242  SER C 249  0                                        
SHEET    2  AD 5 PHE C 252  PRO C 260 -1  O  VAL C 258   N  PHE C 242           
SHEET    3  AD 5 TYR C 276  CYS C 284 -1  O  THR C 277   N  GLN C 259           
SHEET    4  AD 5 VAL C 294  ARG C 302 -1  O  LEU C 296   N  ILE C 280           
SHEET    5  AD 5 VAL C 419  GLU C 420  1  O  VAL C 419   N  PRO C 297           
SHEET    1  AE 8 PHE C 242  SER C 249  0                                        
SHEET    2  AE 8 PHE C 252  PRO C 260 -1  O  VAL C 258   N  PHE C 242           
SHEET    3  AE 8 TYR C 276  CYS C 284 -1  O  THR C 277   N  GLN C 259           
SHEET    4  AE 8 VAL C 294  ARG C 302 -1  O  LEU C 296   N  ILE C 280           
SHEET    5  AE 8 VAL C 305  ALA C 316 -1  O  TYR C 307   N  CYS C 300           
SHEET    6  AE 8 VAL C 334  LYS C 341 -1  O  VAL C 334   N  ALA C 316           
SHEET    7  AE 8 SER C 353  PRO C 359 -1  O  PHE C 358   N  LEU C 335           
SHEET    8  AE 8 LEU C 422  THR C 427 -1  O  LEU C 424   N  LEU C 355           
SHEET    1  AF 4 LEU C 432  TYR C 440  0                                        
SHEET    2  AF 4 TYR C 443  THR C 450 -1  O  PHE C 447   N  ALA C 436           
SHEET    3  AF 4 LYS C 454  ALA C 460 -1  O  ILE C 458   N  VAL C 446           
SHEET    4  AF 4 GLY C 467  SER C 474 -1  O  VAL C 468   N  ARG C 459           
SHEET    1  AG 3 MET C 536  SER C 538  0                                        
SHEET    2  AG 3 GLY C 529  CYS C 531 -1  N  CYS C 531   O  MET C 536           
SHEET    3  AG 3 PHE C 552  ALA C 553 -1  O  ALA C 553   N  TRP C 530           
SHEET    1  AH 4 SER C 561  HIS C 565  0                                        
SHEET    2  AH 4 LEU C 577  ASN C 583 -1  O  VAL C 581   N  GLU C 563           
SHEET    3  AH 4 GLN C 610  ILE C 614 -1  O  VAL C 611   N  LEU C 580           
SHEET    4  AH 4 GLN C 605  SER C 607 -1  N  SER C 607   O  GLN C 610           
SHEET    1  AI 5 SER C 568  SER C 570  0                                        
SHEET    2  AI 5 ILE C 645  TYR C 654  1  O  TYR C 654   N  ILE C 569           
SHEET    3  AI 5 TRP C 630  SER C 639 -1  N  LEU C 633   O  PHE C 651           
SHEET    4  AI 5 ILE C 592  PHE C 596 -1  N  ALA C 595   O  GLN C 636           
SHEET    5  AI 5 THR C 600  GLU C 603 -1  O  VAL C 602   N  CYS C 594           
SHEET    1  AJ 3 LEU C 680  THR C 682  0                                        
SHEET    2  AJ 3 HIS C 673  CYS C 675 -1  N  HIS C 673   O  THR C 682           
SHEET    3  AJ 3 ARG C 694  ILE C 695 -1  O  ILE C 695   N  TRP C 674           
SHEET    1  AK 4 THR D  40  HIS D  42  0                                        
SHEET    2  AK 4 GLN D 502  PRO D 507 -1  O  VAL D 503   N  PHE D  41           
SHEET    3  AK 4 TYR D 494  MET D 498 -1  N  VAL D 497   O  THR D 504           
SHEET    4  AK 4 ALA D 487  PHE D 488 -1  N  ALA D 487   O  TYR D 496           
SHEET    1  AL 4 PHE D  50  VAL D  55  0                                        
SHEET    2  AL 4 VAL D  62  ALA D  66 -1  O  TYR D  63   N  THR D  54           
SHEET    3  AL 4 ARG D  69  LEU D  73 -1  O  LEU D  73   N  VAL D  62           
SHEET    4  AL 4 ILE D  79  LYS D  84 -1  O  GLN D  80   N  LYS D  72           
SHEET    1  AM 2 GLU D  88  ASP D  90  0                                        
SHEET    2  AM 2 THR D 108  THR D 110 -1  O  THR D 108   N  ASP D  90           
SHEET    1  AN 4 ASN D 114  ASP D 120  0                                        
SHEET    2  AN 4 ARG D 125  GLY D 130 -1  O  LEU D 127   N  ILE D 118           
SHEET    3  AN 4 CYS D 137  ARG D 141 -1  O  LEU D 140   N  LEU D 126           
SHEET    4  AN 4 ILE D 147  VAL D 149 -1  O  LEU D 148   N  LEU D 139           
SHEET    1  AO 4 MET D 168  VAL D 173  0                                        
SHEET    2  AO 4 LYS D 181  THR D 186 -1  O  PHE D 183   N  VAL D 171           
SHEET    3  AO 4 LEU D 198  LYS D 202 -1  O  ARG D 201   N  LEU D 182           
SHEET    4  AO 4 LEU D 225  ILE D 226 -1  O  ILE D 226   N  LEU D 198           
SHEET    1  AP 5 PHE D 242  SER D 249  0                                        
SHEET    2  AP 5 PHE D 252  PRO D 260 -1  O  VAL D 258   N  PHE D 242           
SHEET    3  AP 5 TYR D 276  CYS D 284 -1  O  THR D 277   N  GLN D 259           
SHEET    4  AP 5 VAL D 294  ARG D 302 -1  O  LEU D 296   N  ILE D 280           
SHEET    5  AP 5 VAL D 419  GLU D 420  1  O  VAL D 419   N  PRO D 297           
SHEET    1  AQ 8 PHE D 242  SER D 249  0                                        
SHEET    2  AQ 8 PHE D 252  PRO D 260 -1  O  VAL D 258   N  PHE D 242           
SHEET    3  AQ 8 TYR D 276  CYS D 284 -1  O  THR D 277   N  GLN D 259           
SHEET    4  AQ 8 VAL D 294  ARG D 302 -1  O  LEU D 296   N  ILE D 280           
SHEET    5  AQ 8 VAL D 305  ALA D 316 -1  O  TYR D 307   N  CYS D 300           
SHEET    6  AQ 8 VAL D 334  LYS D 341 -1  O  VAL D 334   N  ALA D 316           
SHEET    7  AQ 8 SER D 353  PRO D 359 -1  O  PHE D 358   N  LEU D 335           
SHEET    8  AQ 8 LEU D 422  THR D 427 -1  O  LEU D 424   N  LEU D 355           
SHEET    1  AR 4 LEU D 432  TYR D 440  0                                        
SHEET    2  AR 4 TYR D 443  THR D 450 -1  O  PHE D 447   N  ALA D 436           
SHEET    3  AR 4 LYS D 454  ALA D 460 -1  O  ILE D 458   N  VAL D 446           
SHEET    4  AR 4 GLY D 467  SER D 474 -1  O  VAL D 468   N  ARG D 459           
SHEET    1  AS 3 MET D 536  SER D 538  0                                        
SHEET    2  AS 3 GLY D 529  CYS D 531 -1  N  CYS D 531   O  MET D 536           
SHEET    3  AS 3 PHE D 552  ALA D 553 -1  O  ALA D 553   N  TRP D 530           
SHEET    1  AT 4 SER D 561  HIS D 565  0                                        
SHEET    2  AT 4 LEU D 577  ASN D 583 -1  O  VAL D 581   N  GLU D 563           
SHEET    3  AT 4 GLN D 610  ILE D 614 -1  O  VAL D 611   N  LEU D 580           
SHEET    4  AT 4 GLN D 605  SER D 607 -1  N  SER D 607   O  GLN D 610           
SHEET    1  AU 5 SER D 568  SER D 570  0                                        
SHEET    2  AU 5 ILE D 645  TYR D 654  1  O  TYR D 654   N  ILE D 569           
SHEET    3  AU 5 TRP D 630  SER D 639 -1  N  LEU D 633   O  PHE D 651           
SHEET    4  AU 5 ILE D 592  PHE D 596 -1  N  ALA D 595   O  GLN D 636           
SHEET    5  AU 5 THR D 600  GLU D 603 -1  O  VAL D 602   N  CYS D 594           
SHEET    1  AV 3 LEU D 680  THR D 682  0                                        
SHEET    2  AV 3 HIS D 673  CYS D 675 -1  N  HIS D 673   O  THR D 682           
SHEET    3  AV 3 ARG D 694  ILE D 695 -1  O  ILE D 695   N  TRP D 674           
SHEET    1  AW 4 THR E  40  HIS E  42  0                                        
SHEET    2  AW 4 GLN E 502  PRO E 507 -1  O  VAL E 503   N  PHE E  41           
SHEET    3  AW 4 TYR E 494  MET E 498 -1  N  VAL E 497   O  THR E 504           
SHEET    4  AW 4 ALA E 487  PHE E 488 -1  N  ALA E 487   O  TYR E 496           
SHEET    1  AX 4 PHE E  50  VAL E  55  0                                        
SHEET    2  AX 4 VAL E  62  ALA E  66 -1  O  TYR E  63   N  THR E  54           
SHEET    3  AX 4 ARG E  69  LEU E  73 -1  O  LEU E  73   N  VAL E  62           
SHEET    4  AX 4 ILE E  79  LYS E  84 -1  O  GLN E  80   N  LYS E  72           
SHEET    1  AY 2 GLU E  88  ASP E  90  0                                        
SHEET    2  AY 2 THR E 108  THR E 110 -1  O  THR E 108   N  ASP E  90           
SHEET    1  AZ 4 ASN E 114  ASP E 120  0                                        
SHEET    2  AZ 4 ARG E 125  GLY E 130 -1  O  LEU E 127   N  ILE E 118           
SHEET    3  AZ 4 CYS E 137  ARG E 141 -1  O  LEU E 140   N  LEU E 126           
SHEET    4  AZ 4 ILE E 147  VAL E 149 -1  O  LEU E 148   N  LEU E 139           
SHEET    1  BA 4 MET E 168  VAL E 173  0                                        
SHEET    2  BA 4 LYS E 181  THR E 186 -1  O  PHE E 183   N  VAL E 171           
SHEET    3  BA 4 LEU E 198  LYS E 202 -1  O  ARG E 201   N  LEU E 182           
SHEET    4  BA 4 LEU E 225  ILE E 226 -1  O  ILE E 226   N  LEU E 198           
SHEET    1  BB 5 PHE E 242  SER E 249  0                                        
SHEET    2  BB 5 PHE E 252  PRO E 260 -1  O  VAL E 258   N  PHE E 242           
SHEET    3  BB 5 TYR E 276  CYS E 284 -1  O  THR E 277   N  GLN E 259           
SHEET    4  BB 5 VAL E 294  ARG E 302 -1  O  LEU E 296   N  ILE E 280           
SHEET    5  BB 5 VAL E 419  GLU E 420  1  O  VAL E 419   N  PRO E 297           
SHEET    1  BC 8 PHE E 242  SER E 249  0                                        
SHEET    2  BC 8 PHE E 252  PRO E 260 -1  O  VAL E 258   N  PHE E 242           
SHEET    3  BC 8 TYR E 276  CYS E 284 -1  O  THR E 277   N  GLN E 259           
SHEET    4  BC 8 VAL E 294  ARG E 302 -1  O  LEU E 296   N  ILE E 280           
SHEET    5  BC 8 VAL E 305  ALA E 316 -1  O  TYR E 307   N  CYS E 300           
SHEET    6  BC 8 VAL E 334  LYS E 341 -1  O  VAL E 334   N  ALA E 316           
SHEET    7  BC 8 SER E 353  PRO E 359 -1  O  PHE E 358   N  LEU E 335           
SHEET    8  BC 8 LEU E 422  THR E 427 -1  O  LEU E 424   N  LEU E 355           
SHEET    1  BD 4 LEU E 432  TYR E 440  0                                        
SHEET    2  BD 4 TYR E 443  THR E 450 -1  O  PHE E 447   N  ALA E 436           
SHEET    3  BD 4 LYS E 454  ALA E 460 -1  O  ILE E 458   N  VAL E 446           
SHEET    4  BD 4 GLY E 467  SER E 474 -1  O  VAL E 468   N  ARG E 459           
SHEET    1  BE 3 MET E 536  SER E 538  0                                        
SHEET    2  BE 3 GLY E 529  CYS E 531 -1  N  CYS E 531   O  MET E 536           
SHEET    3  BE 3 PHE E 552  ALA E 553 -1  O  ALA E 553   N  TRP E 530           
SHEET    1  BF 4 SER E 561  HIS E 565  0                                        
SHEET    2  BF 4 LEU E 577  ASN E 583 -1  O  VAL E 581   N  GLU E 563           
SHEET    3  BF 4 GLN E 610  ILE E 614 -1  O  VAL E 611   N  LEU E 580           
SHEET    4  BF 4 GLN E 605  SER E 607 -1  N  SER E 607   O  GLN E 610           
SHEET    1  BG 5 SER E 568  SER E 570  0                                        
SHEET    2  BG 5 ILE E 645  TYR E 654  1  O  TYR E 654   N  ILE E 569           
SHEET    3  BG 5 TRP E 630  SER E 639 -1  N  LEU E 633   O  PHE E 651           
SHEET    4  BG 5 ILE E 592  PHE E 596 -1  N  ALA E 595   O  GLN E 636           
SHEET    5  BG 5 THR E 600  GLU E 603 -1  O  VAL E 602   N  CYS E 594           
SHEET    1  BH 3 LEU E 680  THR E 682  0                                        
SHEET    2  BH 3 HIS E 673  CYS E 675 -1  N  HIS E 673   O  THR E 682           
SHEET    3  BH 3 ARG E 694  ILE E 695 -1  O  ILE E 695   N  TRP E 674           
SHEET    1  BI 4 THR F  40  HIS F  42  0                                        
SHEET    2  BI 4 GLN F 502  PRO F 507 -1  O  VAL F 503   N  PHE F  41           
SHEET    3  BI 4 TYR F 494  MET F 498 -1  N  VAL F 497   O  THR F 504           
SHEET    4  BI 4 ALA F 487  PHE F 488 -1  N  ALA F 487   O  TYR F 496           
SHEET    1  BJ 4 PHE F  50  VAL F  55  0                                        
SHEET    2  BJ 4 VAL F  62  ALA F  66 -1  O  TYR F  63   N  THR F  54           
SHEET    3  BJ 4 ARG F  69  LEU F  73 -1  O  LEU F  73   N  VAL F  62           
SHEET    4  BJ 4 ILE F  79  LYS F  84 -1  O  GLN F  80   N  LYS F  72           
SHEET    1  BK 2 GLU F  88  ASP F  90  0                                        
SHEET    2  BK 2 THR F 108  THR F 110 -1  O  THR F 108   N  ASP F  90           
SHEET    1  BL 4 ASN F 114  ASP F 120  0                                        
SHEET    2  BL 4 ARG F 125  GLY F 130 -1  O  LEU F 127   N  ILE F 118           
SHEET    3  BL 4 CYS F 137  ARG F 141 -1  O  LEU F 140   N  LEU F 126           
SHEET    4  BL 4 ILE F 147  VAL F 149 -1  O  LEU F 148   N  LEU F 139           
SHEET    1  BM 4 MET F 168  VAL F 173  0                                        
SHEET    2  BM 4 LYS F 181  THR F 186 -1  O  PHE F 183   N  VAL F 171           
SHEET    3  BM 4 LEU F 198  LYS F 202 -1  O  ARG F 201   N  LEU F 182           
SHEET    4  BM 4 LEU F 225  ILE F 226 -1  O  ILE F 226   N  LEU F 198           
SHEET    1  BN 5 PHE F 242  SER F 249  0                                        
SHEET    2  BN 5 PHE F 252  PRO F 260 -1  O  VAL F 258   N  PHE F 242           
SHEET    3  BN 5 TYR F 276  CYS F 284 -1  O  THR F 277   N  GLN F 259           
SHEET    4  BN 5 VAL F 294  ARG F 302 -1  O  LEU F 296   N  ILE F 280           
SHEET    5  BN 5 VAL F 419  GLU F 420  1  O  VAL F 419   N  PRO F 297           
SHEET    1  BO 8 PHE F 242  SER F 249  0                                        
SHEET    2  BO 8 PHE F 252  PRO F 260 -1  O  VAL F 258   N  PHE F 242           
SHEET    3  BO 8 TYR F 276  CYS F 284 -1  O  THR F 277   N  GLN F 259           
SHEET    4  BO 8 VAL F 294  ARG F 302 -1  O  LEU F 296   N  ILE F 280           
SHEET    5  BO 8 VAL F 305  ALA F 316 -1  O  TYR F 307   N  CYS F 300           
SHEET    6  BO 8 VAL F 334  LYS F 341 -1  O  VAL F 334   N  ALA F 316           
SHEET    7  BO 8 SER F 353  PRO F 359 -1  O  PHE F 358   N  LEU F 335           
SHEET    8  BO 8 LEU F 422  THR F 427 -1  O  LEU F 424   N  LEU F 355           
SHEET    1  BP 4 LEU F 432  TYR F 440  0                                        
SHEET    2  BP 4 TYR F 443  THR F 450 -1  O  PHE F 447   N  ALA F 436           
SHEET    3  BP 4 LYS F 454  ALA F 460 -1  O  ILE F 458   N  VAL F 446           
SHEET    4  BP 4 GLY F 467  SER F 474 -1  O  VAL F 468   N  ARG F 459           
SHEET    1  BQ 3 MET F 536  SER F 538  0                                        
SHEET    2  BQ 3 GLY F 529  CYS F 531 -1  N  CYS F 531   O  MET F 536           
SHEET    3  BQ 3 PHE F 552  ALA F 553 -1  O  ALA F 553   N  TRP F 530           
SHEET    1  BR 4 SER F 561  HIS F 565  0                                        
SHEET    2  BR 4 LEU F 577  ASN F 583 -1  O  VAL F 581   N  GLU F 563           
SHEET    3  BR 4 GLN F 610  ILE F 614 -1  O  VAL F 611   N  LEU F 580           
SHEET    4  BR 4 GLN F 605  SER F 607 -1  N  SER F 607   O  GLN F 610           
SHEET    1  BS 5 SER F 568  SER F 570  0                                        
SHEET    2  BS 5 ILE F 645  TYR F 654  1  O  TYR F 654   N  ILE F 569           
SHEET    3  BS 5 TRP F 630  SER F 639 -1  N  LEU F 633   O  PHE F 651           
SHEET    4  BS 5 ILE F 592  PHE F 596 -1  N  ALA F 595   O  GLN F 636           
SHEET    5  BS 5 THR F 600  GLU F 603 -1  O  VAL F 602   N  CYS F 594           
SHEET    1  BT 3 LEU F 680  THR F 682  0                                        
SHEET    2  BT 3 HIS F 673  CYS F 675 -1  N  HIS F 673   O  THR F 682           
SHEET    3  BT 3 ARG F 694  ILE F 695 -1  O  ILE F 695   N  TRP F 674           
SHEET    1  BU 4 ILE G  46  PHE G  48  0                                        
SHEET    2  BU 4 VAL G 509  PRO G 513 -1  O  GLN G 511   N  ILE G  46           
SHEET    3  BU 4 GLN G 500  GLY G 504 -1  N  LEU G 501   O  LEU G 512           
SHEET    4  BU 4 ALA G 491  SER G 495 -1  N  ALA G 491   O  GLY G 504           
SHEET    1  BV 4 THR G  59  ASP G  63  0                                        
SHEET    2  BV 4 ARG G  68  ALA G  73 -1  O  TYR G  70   N  LEU G  61           
SHEET    3  BV 4 HIS G  76  ASN G  81 -1  O  PHE G  80   N  LEU G  69           
SHEET    4  BV 4 PHE G  88  VAL G  92 -1  O  GLN G  89   N  SER G  79           
SHEET    1  BW 4 ILE G 118  ALA G 123  0                                        
SHEET    2  BW 4 HIS G 128  GLY G 133 -1  O  TYR G 130   N  GLU G 122           
SHEET    3  BW 4 ILE G 140  GLU G 145 -1  O  ILE G 144   N  LEU G 129           
SHEET    4  BW 4 LYS G 156  ASN G 164 -1  O  GLU G 163   N  CYS G 141           
SHEET    1  BX 4 ALA G 178  ILE G 182  0                                        
SHEET    2  BX 4 GLU G 185  ALA G 191 -1  O  TYR G 187   N  LEU G 180           
SHEET    3  BX 4 PHE G 199  LEU G 205 -1  O  PHE G 202   N  SER G 188           
SHEET    4  BX 4 ILE G 211  ARG G 212 -1  O  ILE G 211   N  ARG G 203           
SHEET    1  BY 4 ARG G 225  ILE G 232  0                                        
SHEET    2  BY 4 LYS G 242  ASN G 250 -1  O  TYR G 244   N  HIS G 230           
SHEET    3  BY 4 THR G 261  CYS G 269 -1  O  ILE G 268   N  VAL G 243           
SHEET    4  BY 4 LEU G 287  ARG G 290 -1  O  ALA G 289   N  ILE G 265           
SHEET    1  BZ 2 SER G 294  VAL G 295  0                                        
SHEET    2  BZ 2 THR G 303  HIS G 304 -1  O  THR G 303   N  VAL G 295           
SHEET    1  CA 4 GLU G 307  MET G 314  0                                        
SHEET    2  CA 4 ILE G 323  THR G 329 -1  O  ILE G 323   N  MET G 314           
SHEET    3  CA 4 SER G 338  TYR G 343 -1  O  ALA G 339   N  PHE G 328           
SHEET    4  CA 4 MET G 422  LYS G 424 -1  O  LYS G 424   N  SER G 338           
SHEET    1  CB 2 ALA G 357  HIS G 358  0                                        
SHEET    2  CB 2 VAL G 367  PRO G 368 -1  O  VAL G 367   N  HIS G 358           
SHEET    1  CC 4 PHE G 431  ASP G 440  0                                        
SHEET    2  CC 4 GLN G 445  THR G 453 -1  O  GLY G 452   N  GLN G 433           
SHEET    3  CC 4 VAL G 458  VAL G 462 -1  O  VAL G 461   N  MET G 449           
SHEET    4  CC 4 GLU G 478  MET G 480 -1  O  GLU G 478   N  LYS G 460           
SHEET    1  CD 5 GLY H  29  LYS H  32  0                                        
SHEET    2  CD 5 LYS H  53  GLN H  59  1  O  LEU H  57   N  GLY H  29           
SHEET    3  CD 5 PHE H 118  VAL H 124 -1  O  ILE H 121   N  TRP H  56           
SHEET    4  CD 5 TYR H  86  ASP H  91 -1  N  GLU H  88   O  LYS H 122           
SHEET    5  CD 5 ARG H  98  PHE H 103 -1  O  ARG H  98   N  ASP H  91           
SHEET    1  CE 4 GLY H  37  THR H  40  0                                        
SHEET    2  CE 4 SER H 135  ILE H 140 -1  O  ILE H 136   N  LEU H  39           
SHEET    3  CE 4 ILE H  67  PHE H  71 -1  N  MET H  68   O  GLU H 139           
SHEET    4  CE 4 VAL H 112  VAL H 113 -1  O  VAL H 112   N  ILE H  69           
SSBOND   1 CYS A   94    CYS A  103                          1555   1555  2.04  
SSBOND   2 CYS A  129    CYS A  137                          1555   1555  2.03  
SSBOND   3 CYS A  284    CYS A  405                          1555   1555  2.04  
SSBOND   4 CYS A  300    CYS A  356                          1555   1555  2.02  
SSBOND   5 CYS A  374    CYS A  393                          1555   1555  2.04  
SSBOND   6 CYS A  511    CYS A  528                          1555   1555  2.03  
SSBOND   7 CYS A  517    CYS A  559                          1555   1555  2.03  
SSBOND   8 CYS A  520    CYS A  537                          1555   1555  2.04  
SSBOND   9 CYS A  531    CYS A  543                          1555   1555  2.04  
SSBOND  10 CYS A  594    CYS A  613                          1555   1555  2.02  
SSBOND  11 CYS A  656    CYS A  672                          1555   1555  2.04  
SSBOND  12 CYS A  662    CYS A  701                          1555   1555  2.03  
SSBOND  13 CYS A  665    CYS A  681                          1555   1555  2.04  
SSBOND  14 CYS A  675    CYS A  688                          1555   1555  2.03  
SSBOND  15 CYS B   94    CYS B  103                          1555   1555  2.04  
SSBOND  16 CYS B  129    CYS B  137                          1555   1555  2.03  
SSBOND  17 CYS B  284    CYS B  405                          1555   1555  2.04  
SSBOND  18 CYS B  300    CYS B  356                          1555   1555  2.02  
SSBOND  19 CYS B  374    CYS B  393                          1555   1555  2.04  
SSBOND  20 CYS B  511    CYS B  528                          1555   1555  2.03  
SSBOND  21 CYS B  517    CYS B  559                          1555   1555  2.03  
SSBOND  22 CYS B  520    CYS B  537                          1555   1555  2.04  
SSBOND  23 CYS B  531    CYS B  543                          1555   1555  2.04  
SSBOND  24 CYS B  594    CYS B  613                          1555   1555  2.02  
SSBOND  25 CYS B  656    CYS B  672                          1555   1555  2.04  
SSBOND  26 CYS B  662    CYS B  701                          1555   1555  2.03  
SSBOND  27 CYS B  665    CYS B  681                          1555   1555  2.04  
SSBOND  28 CYS B  675    CYS B  688                          1555   1555  2.03  
SSBOND  29 CYS C   94    CYS C  103                          1555   1555  2.04  
SSBOND  30 CYS C  129    CYS C  137                          1555   1555  2.04  
SSBOND  31 CYS C  284    CYS C  405                          1555   1555  2.04  
SSBOND  32 CYS C  300    CYS C  356                          1555   1555  2.02  
SSBOND  33 CYS C  374    CYS C  393                          1555   1555  2.04  
SSBOND  34 CYS C  511    CYS C  528                          1555   1555  2.03  
SSBOND  35 CYS C  517    CYS C  559                          1555   1555  2.03  
SSBOND  36 CYS C  520    CYS C  537                          1555   1555  2.04  
SSBOND  37 CYS C  531    CYS C  543                          1555   1555  2.04  
SSBOND  38 CYS C  594    CYS C  613                          1555   1555  2.02  
SSBOND  39 CYS C  656    CYS C  672                          1555   1555  2.04  
SSBOND  40 CYS C  662    CYS C  701                          1555   1555  2.03  
SSBOND  41 CYS C  665    CYS C  681                          1555   1555  2.04  
SSBOND  42 CYS C  675    CYS C  688                          1555   1555  2.03  
SSBOND  43 CYS D   94    CYS D  103                          1555   1555  2.04  
SSBOND  44 CYS D  129    CYS D  137                          1555   1555  2.03  
SSBOND  45 CYS D  284    CYS D  405                          1555   1555  2.04  
SSBOND  46 CYS D  300    CYS D  356                          1555   1555  2.02  
SSBOND  47 CYS D  374    CYS D  393                          1555   1555  2.04  
SSBOND  48 CYS D  511    CYS D  528                          1555   1555  2.03  
SSBOND  49 CYS D  517    CYS D  559                          1555   1555  2.03  
SSBOND  50 CYS D  520    CYS D  537                          1555   1555  2.04  
SSBOND  51 CYS D  531    CYS D  543                          1555   1555  2.04  
SSBOND  52 CYS D  594    CYS D  613                          1555   1555  2.02  
SSBOND  53 CYS D  656    CYS D  672                          1555   1555  2.04  
SSBOND  54 CYS D  662    CYS D  701                          1555   1555  2.03  
SSBOND  55 CYS D  665    CYS D  681                          1555   1555  2.04  
SSBOND  56 CYS D  675    CYS D  688                          1555   1555  2.03  
SSBOND  57 CYS E   94    CYS E  103                          1555   1555  2.04  
SSBOND  58 CYS E  129    CYS E  137                          1555   1555  2.03  
SSBOND  59 CYS E  284    CYS E  405                          1555   1555  2.04  
SSBOND  60 CYS E  300    CYS E  356                          1555   1555  2.02  
SSBOND  61 CYS E  374    CYS E  393                          1555   1555  2.04  
SSBOND  62 CYS E  511    CYS E  528                          1555   1555  2.03  
SSBOND  63 CYS E  517    CYS E  559                          1555   1555  2.03  
SSBOND  64 CYS E  520    CYS E  537                          1555   1555  2.05  
SSBOND  65 CYS E  531    CYS E  543                          1555   1555  2.04  
SSBOND  66 CYS E  594    CYS E  613                          1555   1555  2.02  
SSBOND  67 CYS E  656    CYS E  672                          1555   1555  2.04  
SSBOND  68 CYS E  662    CYS E  701                          1555   1555  2.03  
SSBOND  69 CYS E  665    CYS E  681                          1555   1555  2.04  
SSBOND  70 CYS E  675    CYS E  688                          1555   1555  2.03  
SSBOND  71 CYS F   94    CYS F  103                          1555   1555  2.04  
SSBOND  72 CYS F  129    CYS F  137                          1555   1555  2.04  
SSBOND  73 CYS F  284    CYS F  405                          1555   1555  2.04  
SSBOND  74 CYS F  300    CYS F  356                          1555   1555  2.02  
SSBOND  75 CYS F  374    CYS F  393                          1555   1555  2.04  
SSBOND  76 CYS F  511    CYS F  528                          1555   1555  2.03  
SSBOND  77 CYS F  517    CYS F  559                          1555   1555  2.03  
SSBOND  78 CYS F  520    CYS F  537                          1555   1555  2.04  
SSBOND  79 CYS F  531    CYS F  543                          1555   1555  2.04  
SSBOND  80 CYS F  594    CYS F  613                          1555   1555  2.02  
SSBOND  81 CYS F  656    CYS F  672                          1555   1555  2.04  
SSBOND  82 CYS F  662    CYS F  701                          1555   1555  2.03  
SSBOND  83 CYS F  665    CYS F  681                          1555   1555  2.04  
SSBOND  84 CYS F  675    CYS F  688                          1555   1555  2.03  
SSBOND  85 CYS G  103    CYS G  114                          1555   1555  2.05  
SSBOND  86 CYS G  132    CYS G  141                          1555   1555  2.07  
SSBOND  87 CYS G  269    CYS G  381                          1555   1555  2.05  
SSBOND  88 CYS G  293    CYS G  341                          1555   1555  2.06  
SSBOND  89 CYS H   27    CYS H   54                          1555   1555  2.06  
SSBOND  90 CYS H   82    CYS H  104                          1555   1555  2.06  
LINK         O   THR H 129                CA    CA H 601     1555   1555  2.30  
LINK         OD2 ASP H  85                CA    CA H 601     1555   1555  2.32  
LINK         OD1 ASP H 126                CA    CA H 601     1555   1555  2.37  
LINK         O   GLU H 128                CA    CA H 601     1555   1555  2.42  
LINK         OE1 GLU H  78                CA    CA H 601     1555   1555  2.44  
CISPEP   1 GLY A   86    PRO A   87          0        -1.42                     
CISPEP   2 TYR A   95    PRO A   96          0        -3.29                     
CISPEP   3 SER A  237    HIS A  238          0         7.75                     
CISPEP   4 GLN A  411    PRO A  412          0        -2.50                     
CISPEP   5 PRO A  463    PRO A  464          0        -0.23                     
CISPEP   6 HIS A  565    PRO A  566          0        -1.53                     
CISPEP   7 GLY B   86    PRO B   87          0        -1.64                     
CISPEP   8 TYR B   95    PRO B   96          0        -3.34                     
CISPEP   9 SER B  237    HIS B  238          0         7.91                     
CISPEP  10 GLN B  411    PRO B  412          0        -2.57                     
CISPEP  11 PRO B  463    PRO B  464          0        -0.36                     
CISPEP  12 HIS B  565    PRO B  566          0        -1.54                     
CISPEP  13 GLY C   86    PRO C   87          0        -1.48                     
CISPEP  14 TYR C   95    PRO C   96          0        -3.37                     
CISPEP  15 SER C  237    HIS C  238          0         7.84                     
CISPEP  16 GLN C  411    PRO C  412          0        -2.54                     
CISPEP  17 PRO C  463    PRO C  464          0        -0.21                     
CISPEP  18 HIS C  565    PRO C  566          0        -1.58                     
CISPEP  19 GLY D   86    PRO D   87          0        -1.52                     
CISPEP  20 TYR D   95    PRO D   96          0        -3.33                     
CISPEP  21 SER D  237    HIS D  238          0         7.66                     
CISPEP  22 GLN D  411    PRO D  412          0        -2.65                     
CISPEP  23 PRO D  463    PRO D  464          0        -0.26                     
CISPEP  24 HIS D  565    PRO D  566          0        -1.55                     
CISPEP  25 GLY E   86    PRO E   87          0        -1.50                     
CISPEP  26 TYR E   95    PRO E   96          0        -3.33                     
CISPEP  27 SER E  237    HIS E  238          0         7.73                     
CISPEP  28 GLN E  411    PRO E  412          0        -2.55                     
CISPEP  29 PRO E  463    PRO E  464          0        -0.09                     
CISPEP  30 HIS E  565    PRO E  566          0        -1.51                     
CISPEP  31 TYR E  654    ASN E  655          0       -27.71                     
CISPEP  32 GLY F   86    PRO F   87          0        -1.50                     
CISPEP  33 TYR F   95    PRO F   96          0        -3.29                     
CISPEP  34 SER F  237    HIS F  238          0         7.78                     
CISPEP  35 GLN F  411    PRO F  412          0        -2.70                     
CISPEP  36 PRO F  463    PRO F  464          0        -0.16                     
CISPEP  37 HIS F  565    PRO F  566          0        -1.43                     
CISPEP  38 TYR G  375    PRO G  376          0        -0.46                     
CISPEP  39 TYR H   44    PRO H   45          0         7.24                     
SITE     1 AC1  5 GLU H  78  ASP H  85  ASP H 126  GLU H 128                    
SITE     2 AC1  5 THR H 129                                                     
CRYST1  191.632  293.604  252.176  90.00 106.38  90.00 C 1 2 1      24          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.005218  0.000000  0.001533        0.00000                         
SCALE2      0.000000  0.003406  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.004133        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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