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Database: PDB
Entry: 4HR7
LinkDB: 4HR7
Original site: 4HR7 
HEADER    LIGASE/BIOTIN BINDING PROTEIN           26-OCT-12   4HR7              
TITLE     CRYSTAL STRUCTURE OF BIOTIN CARBOXYL CARRIER PROTEIN-BIOTIN           
TITLE    2 CARBOXYLASE COMPLEX FROM E.COLI                                      
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: BIOTIN CARBOXYLASE;                                        
COMPND   3 CHAIN: A, C, E, F;                                                   
COMPND   4 SYNONYM: ACETYL-COA CARBOXYLASE SUBUNIT A, ACC;                      
COMPND   5 EC: 6.3.4.14, 6.4.1.2;                                               
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: BIOTIN CARBOXYL CARRIER PROTEIN OF ACETYL-COA CARBOXYLASE; 
COMPND   9 CHAIN: B, D, G, I;                                                   
COMPND  10 SYNONYM: BCCP;                                                       
COMPND  11 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;                               
SOURCE   3 ORGANISM_TAXID: 83333;                                               
SOURCE   4 STRAIN: K12;                                                         
SOURCE   5 GENE: ACCC, FABG, B3256, JW3224;                                     
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE   8 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);                                 
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PAEP7;                                    
SOURCE  11 MOL_ID: 2;                                                           
SOURCE  12 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;                               
SOURCE  13 ORGANISM_TAXID: 83333;                                               
SOURCE  14 STRAIN: K12;                                                         
SOURCE  15 GENE: ACCB, FABE, B3255, JW3223;                                     
SOURCE  16 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  17 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE  18 EXPRESSION_SYSTEM_STRAIN: BL21(DE3);                                 
SOURCE  19 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  20 EXPRESSION_SYSTEM_PLASMID: PAEP7                                     
KEYWDS    BIOTIN CARBOXYLASE, BIOTIN CARBOXYL CARRIER PROTEIN, ACETYL-COA       
KEYWDS   2 CARBOXYLASE, PROTEIN-PROTEIN INTERACTION, PROTEIN COMPLEX, PROTEIN   
KEYWDS   3 INTERFACE, ANTIBIOTIC TARGET, ATP GRASP, BIOTIN-DEPENDENT            
KEYWDS   4 CARBOXYLASE, FATTY ACID SYNTHESIS, LIGASE-BIOTIN BINDING PROTEIN     
KEYWDS   5 COMPLEX                                                              
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    T.C.BROUSSARD,M.J.KOBE,S.PAKHOMOVA,D.B.NEAU,A.E.PRICE,T.S.CHAMPION,   
AUTHOR   2 G.L.WALDROP                                                          
REVDAT   3   29-MAY-13 4HR7    1       JRNL                                     
REVDAT   2   03-APR-13 4HR7    1       JRNL                                     
REVDAT   1   13-MAR-13 4HR7    0                                                
JRNL        AUTH   T.C.BROUSSARD,M.J.KOBE,S.PAKHOMOVA,D.B.NEAU,A.E.PRICE,       
JRNL        AUTH 2 T.S.CHAMPION,G.L.WALDROP                                     
JRNL        TITL   THE THREE-DIMENSIONAL STRUCTURE OF THE BIOTIN                
JRNL        TITL 2 CARBOXYLASE-BIOTIN CARBOXYL CARRIER PROTEIN COMPLEX OF E.    
JRNL        TITL 3 COLI ACETYL-COA CARBOXYLASE.                                 
JRNL        REF    STRUCTURE                     V.  21   650 2013              
JRNL        REFN                   ISSN 0969-2126                               
JRNL        PMID   23499019                                                     
JRNL        DOI    10.1016/J.STR.2013.02.001                                    
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.50 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.8_1069)                     
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN             
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-                     
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,              
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL            
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE                  
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM             
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,             
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER                
REMARK   3               : ZWART                                                
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.50                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 104.26                         
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : NULL                           
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.4                           
REMARK   3   NUMBER OF REFLECTIONS             : 79181                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.197                           
REMARK   3   R VALUE            (WORKING SET) : 0.195                           
REMARK   3   FREE R VALUE                     : 0.229                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.020                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 3972                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1104.3511 -  7.5752    0.96     2724   156  0.1655 0.1956        
REMARK   3     2  7.5752 -  6.0128    0.99     2750   138  0.1948 0.2042        
REMARK   3     3  6.0128 -  5.2528    0.99     2729   154  0.1796 0.2007        
REMARK   3     4  5.2528 -  4.7725    0.99     2730   150  0.1573 0.1740        
REMARK   3     5  4.7725 -  4.4305    0.99     2726   147  0.1509 0.1732        
REMARK   3     6  4.4305 -  4.1692    0.99     2693   153  0.1491 0.1859        
REMARK   3     7  4.1692 -  3.9604    0.99     2717   139  0.1643 0.2330        
REMARK   3     8  3.9604 -  3.7880    0.99     2715   152  0.1753 0.2360        
REMARK   3     9  3.7880 -  3.6422    0.99     2679   137  0.1927 0.2375        
REMARK   3    10  3.6422 -  3.5165    0.99     2709   143  0.1957 0.2193        
REMARK   3    11  3.5165 -  3.4065    0.99     2701   140  0.2077 0.2239        
REMARK   3    12  3.4065 -  3.3092    0.99     2725   128  0.2148 0.2500        
REMARK   3    13  3.3092 -  3.2220    0.99     2685   147  0.2175 0.2628        
REMARK   3    14  3.2220 -  3.1434    0.99     2696   133  0.2232 0.2398        
REMARK   3    15  3.1434 -  3.0720    0.99     2719   137  0.2169 0.2302        
REMARK   3    16  3.0720 -  3.0066    0.99     2685   151  0.2165 0.2584        
REMARK   3    17  3.0066 -  2.9464    0.99     2705   130  0.2243 0.2458        
REMARK   3    18  2.9464 -  2.8908    0.99     2703   134  0.2350 0.2467        
REMARK   3    19  2.8908 -  2.8392    0.99     2684   140  0.2257 0.2971        
REMARK   3    20  2.8392 -  2.7911    0.99     2679   150  0.2269 0.3036        
REMARK   3    21  2.7911 -  2.7460    0.99     2661   139  0.2373 0.2852        
REMARK   3    22  2.7460 -  2.7038    0.99     2689   139  0.2317 0.2802        
REMARK   3    23  2.7038 -  2.6640    0.99     2684   159  0.2369 0.2791        
REMARK   3    24  2.6640 -  2.6265    0.99     2665   137  0.2461 0.2826        
REMARK   3    25  2.6265 -  2.5910    0.99     2706   146  0.2452 0.2871        
REMARK   3    26  2.5910 -  2.5573    0.99     2655   133  0.2496 0.3043        
REMARK   3    27  2.5573 -  2.5254    0.99     2682   136  0.2707 0.3192        
REMARK   3    28  2.5254 -  2.4950    0.85     2313   124  0.2640 0.3031        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.310            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 24.790           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 38.07                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.003          15973                                  
REMARK   3   ANGLE     :  0.718          21588                                  
REMARK   3   CHIRALITY :  0.041           2416                                  
REMARK   3   PLANARITY :  0.003           2826                                  
REMARK   3   DIHEDRAL  : 13.510           6016                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 20                                         
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: (chain A and resid 1:167)                              
REMARK   3    ORIGIN FOR THE GROUP (A): 193.9519  53.1575  21.0037              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2335 T22:   0.1716                                     
REMARK   3      T33:  -0.0611 T12:   0.0388                                     
REMARK   3      T13:   0.1025 T23:   0.1866                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0894 L22:   0.0699                                     
REMARK   3      L33:   0.0696 L12:   0.0259                                     
REMARK   3      L13:   0.0828 L23:   0.0337                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0280 S12:   0.2226 S13:   0.1415                       
REMARK   3      S21:  -0.1027 S22:   0.1708 S23:   0.1287                       
REMARK   3      S31:  -0.2207 S32:  -0.1290 S33:   0.6652                       
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: (chain A and resid 168:248)                            
REMARK   3    ORIGIN FOR THE GROUP (A): 178.1703  50.4623  35.9411              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2782 T22:   0.2810                                     
REMARK   3      T33:   0.1759 T12:   0.0789                                     
REMARK   3      T13:   0.0533 T23:   0.1254                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0661 L22:   0.0862                                     
REMARK   3      L33:   0.0687 L12:   0.0642                                     
REMARK   3      L13:   0.0234 L23:   0.0299                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0429 S12:  -0.0361 S13:  -0.0230                       
REMARK   3      S21:   0.0922 S22:   0.0534 S23:  -0.0490                       
REMARK   3      S31:  -0.1307 S32:  -0.0284 S33:   0.1134                       
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: (chain A and resid 249:446)                            
REMARK   3    ORIGIN FOR THE GROUP (A): 190.3989  36.7733  25.9636              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2250 T22:   0.2286                                     
REMARK   3      T33:   0.1468 T12:   0.0341                                     
REMARK   3      T13:   0.0565 T23:   0.1188                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1792 L22:   0.1390                                     
REMARK   3      L33:   0.1802 L12:   0.0716                                     
REMARK   3      L13:   0.0382 L23:   0.1294                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0883 S12:   0.0028 S13:  -0.0943                       
REMARK   3      S21:   0.0882 S22:   0.1203 S23:   0.1182                       
REMARK   3      S31:  -0.0399 S32:  -0.1046 S33:   0.5451                       
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: (chain B and resid 77:96)                              
REMARK   3    ORIGIN FOR THE GROUP (A): 213.1941  57.4118  41.7092              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3316 T22:   0.2630                                     
REMARK   3      T33:   0.0647 T12:   0.0061                                     
REMARK   3      T13:   0.0583 T23:  -0.0398                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0392 L22:   0.0738                                     
REMARK   3      L33:   0.0050 L12:   0.0309                                     
REMARK   3      L13:  -0.0130 L23:  -0.0019                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0467 S12:   0.0743 S13:   0.0256                       
REMARK   3      S21:  -0.0073 S22:   0.0743 S23:  -0.0366                       
REMARK   3      S31:  -0.0135 S32:  -0.0549 S33:   0.0632                       
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: (chain B and resid 97:156)                             
REMARK   3    ORIGIN FOR THE GROUP (A): 211.2585  61.4737  42.7055              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2549 T22:   0.1774                                     
REMARK   3      T33:   0.1333 T12:   0.0483                                     
REMARK   3      T13:   0.0753 T23:  -0.0149                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0096 L22:   0.2678                                     
REMARK   3      L33:   0.0260 L12:   0.0036                                     
REMARK   3      L13:  -0.0127 L23:  -0.0373                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0274 S12:   0.0296 S13:   0.0420                       
REMARK   3      S21:   0.1160 S22:   0.0127 S23:  -0.0445                       
REMARK   3      S31:  -0.1097 S32:  -0.0027 S33:  -0.0030                       
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: (chain C and resid 1:128)                              
REMARK   3    ORIGIN FOR THE GROUP (A): 195.8741  -0.0047  21.0725              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2706 T22:   0.2195                                     
REMARK   3      T33:   0.4684 T12:  -0.0200                                     
REMARK   3      T13:  -0.0428 T23:  -0.0035                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0712 L22:   0.1350                                     
REMARK   3      L33:   0.0904 L12:  -0.0243                                     
REMARK   3      L13:  -0.0624 L23:  -0.0489                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0665 S12:   0.0878 S13:  -0.4285                       
REMARK   3      S21:   0.0853 S22:   0.0618 S23:  -0.0166                       
REMARK   3      S31:   0.1682 S32:  -0.0446 S33:   0.0147                       
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: (chain C and resid 129:203)                            
REMARK   3    ORIGIN FOR THE GROUP (A): 193.6887  -7.5695 -18.8412              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3526 T22:   0.4991                                     
REMARK   3      T33:   0.4966 T12:  -0.0579                                     
REMARK   3      T13:   0.0402 T23:  -0.2269                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0077 L22:   0.0025                                     
REMARK   3      L33:   0.0076 L12:  -0.0037                                     
REMARK   3      L13:  -0.0089 L23:   0.0007                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0038 S12:   0.0080 S13:  -0.1073                       
REMARK   3      S21:  -0.0227 S22:   0.0005 S23:  -0.0307                       
REMARK   3      S31:  -0.0114 S32:   0.0532 S33:   0.0000                       
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    SELECTION: (chain C and resid 204:446)                            
REMARK   3    ORIGIN FOR THE GROUP (A): 195.4273  14.2392   5.9119              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1410 T22:   0.2563                                     
REMARK   3      T33:   0.2251 T12:  -0.0546                                     
REMARK   3      T13:  -0.0064 T23:  -0.0509                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0470 L22:   0.3104                                     
REMARK   3      L33:   0.1540 L12:  -0.0750                                     
REMARK   3      L13:   0.0064 L23:  -0.0310                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0441 S12:   0.2783 S13:  -0.2008                       
REMARK   3      S21:   0.0164 S22:   0.1444 S23:   0.0103                       
REMARK   3      S31:   0.0386 S32:   0.0073 S33:   0.1770                       
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    SELECTION: (chain D and resid 80:113)                             
REMARK   3    ORIGIN FOR THE GROUP (A): 220.2505 -12.6164   3.9407              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4801 T22:   0.4309                                     
REMARK   3      T33:   0.7064 T12:   0.0317                                     
REMARK   3      T13:   0.0122 T23:  -0.2610                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0040 L22:   0.0045                                     
REMARK   3      L33:   0.0105 L12:  -0.0021                                     
REMARK   3      L13:   0.0044 L23:   0.0035                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0204 S12:   0.0876 S13:   0.0273                       
REMARK   3      S21:  -0.0394 S22:  -0.0139 S23:  -0.0376                       
REMARK   3      S31:   0.0413 S32:  -0.0346 S33:  -0.0000                       
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    SELECTION: (chain D and resid 114:156)                            
REMARK   3    ORIGIN FOR THE GROUP (A): 221.1547 -10.0542   8.1880              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4802 T22:   0.3971                                     
REMARK   3      T33:   0.6967 T12:   0.0149                                     
REMARK   3      T13:  -0.0203 T23:  -0.2164                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0041 L22:   0.0066                                     
REMARK   3      L33:   0.0123 L12:  -0.0055                                     
REMARK   3      L13:  -0.0074 L23:   0.0059                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0188 S12:  -0.0080 S13:   0.0511                       
REMARK   3      S21:  -0.0952 S22:  -0.0020 S23:  -0.0586                       
REMARK   3      S31:   0.1198 S32:   0.0010 S33:  -0.0000                       
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    SELECTION: (chain E and resid 1:138)                              
REMARK   3    ORIGIN FOR THE GROUP (A): 239.6807  49.2400  36.6171              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2058 T22:   0.1667                                     
REMARK   3      T33:   0.0903 T12:  -0.0295                                     
REMARK   3      T13:   0.0258 T23:  -0.0585                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0485 L22:   0.2287                                     
REMARK   3      L33:   0.1095 L12:   0.0082                                     
REMARK   3      L13:   0.0149 L23:  -0.1275                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0566 S12:  -0.0413 S13:   0.0776                       
REMARK   3      S21:  -0.0233 S22:   0.0940 S23:   0.0831                       
REMARK   3      S31:  -0.1119 S32:   0.0091 S33:   0.0997                       
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    SELECTION: (chain E and resid 139:238)                            
REMARK   3    ORIGIN FOR THE GROUP (A): 262.3099  48.8129  17.1203              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3044 T22:   0.4455                                     
REMARK   3      T33:   0.0936 T12:  -0.0168                                     
REMARK   3      T13:   0.0953 T23:  -0.0844                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0164 L22:   0.0165                                     
REMARK   3      L33:   0.0304 L12:   0.0110                                     
REMARK   3      L13:   0.0130 L23:  -0.0263                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0632 S12:   0.0634 S13:   0.0022                       
REMARK   3      S21:  -0.0792 S22:   0.0202 S23:  -0.0114                       
REMARK   3      S31:  -0.0728 S32:   0.0428 S33:   0.1536                       
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    SELECTION: (chain E and resid 239:446)                            
REMARK   3    ORIGIN FOR THE GROUP (A): 247.1735  33.9669  26.3688              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1826 T22:   0.2806                                     
REMARK   3      T33:   0.1269 T12:   0.0172                                     
REMARK   3      T13:  -0.0059 T23:  -0.0952                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1883 L22:   0.0705                                     
REMARK   3      L33:   0.0280 L12:  -0.1156                                     
REMARK   3      L13:   0.0479 L23:  -0.0427                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1517 S12:   0.1462 S13:  -0.2224                       
REMARK   3      S21:   0.0237 S22:   0.0079 S23:  -0.0038                       
REMARK   3      S31:   0.0254 S32:   0.1527 S33:   0.2785                       
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    SELECTION: (chain F and resid 1:126)                              
REMARK   3    ORIGIN FOR THE GROUP (A): 237.6162  -2.3090  28.1942              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3241 T22:   0.1744                                     
REMARK   3      T33:   0.7949 T12:   0.0640                                     
REMARK   3      T13:  -0.1977 T23:  -0.0624                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1502 L22:   0.0268                                     
REMARK   3      L33:   0.0211 L12:  -0.0478                                     
REMARK   3      L13:  -0.0078 L23:   0.0025                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0363 S12:   0.0182 S13:  -0.4212                       
REMARK   3      S21:  -0.0709 S22:   0.0571 S23:   0.0466                       
REMARK   3      S31:   0.1491 S32:   0.0739 S33:   0.1072                       
REMARK   3   TLS GROUP : 15                                                     
REMARK   3    SELECTION: (chain F and resid 127:338)                            
REMARK   3    ORIGIN FOR THE GROUP (A): 245.4905   0.5001  52.6273              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2221 T22:   0.3621                                     
REMARK   3      T33:   0.5700 T12:   0.0205                                     
REMARK   3      T13:  -0.0815 T23:   0.1861                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0063 L22:   0.1411                                     
REMARK   3      L33:   0.1162 L12:   0.0037                                     
REMARK   3      L13:   0.0051 L23:   0.1162                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0578 S12:  -0.1698 S13:  -0.2985                       
REMARK   3      S21:   0.0117 S22:   0.0311 S23:   0.0505                       
REMARK   3      S31:   0.0709 S32:   0.0066 S33:   0.1927                       
REMARK   3   TLS GROUP : 16                                                     
REMARK   3    SELECTION: (chain F and resid 339:446)                            
REMARK   3    ORIGIN FOR THE GROUP (A): 229.2288  17.0355  44.1350              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1810 T22:   0.2529                                     
REMARK   3      T33:   0.3559 T12:  -0.0015                                     
REMARK   3      T13:  -0.0610 T23:   0.0761                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1367 L22:   0.0904                                     
REMARK   3      L33:   0.3901 L12:  -0.0576                                     
REMARK   3      L13:  -0.2035 L23:   0.1459                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0861 S12:  -0.2453 S13:  -0.1284                       
REMARK   3      S21:  -0.0621 S22:   0.1074 S23:   0.0785                       
REMARK   3      S31:  -0.0209 S32:  -0.0650 S33:   0.1574                       
REMARK   3   TLS GROUP : 17                                                     
REMARK   3    SELECTION: (chain G and resid 80:108)                             
REMARK   3    ORIGIN FOR THE GROUP (A): 211.0651 -14.2015  42.8594              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5269 T22:   0.3873                                     
REMARK   3      T33:   0.6159 T12:  -0.0117                                     
REMARK   3      T13:  -0.1334 T23:   0.1485                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0080 L22:   0.0082                                     
REMARK   3      L33:   0.0068 L12:   0.0001                                     
REMARK   3      L13:  -0.0016 L23:  -0.0008                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0052 S12:  -0.0695 S13:   0.0608                       
REMARK   3      S21:   0.0388 S22:   0.0114 S23:  -0.0327                       
REMARK   3      S31:   0.0263 S32:  -0.0424 S33:   0.0000                       
REMARK   3   TLS GROUP : 18                                                     
REMARK   3    SELECTION: (chain G and resid 109:156)                            
REMARK   3    ORIGIN FOR THE GROUP (A): 212.5412 -12.5008  39.1711              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4529 T22:   0.3784                                     
REMARK   3      T33:   0.7308 T12:  -0.0542                                     
REMARK   3      T13:  -0.1102 T23:   0.1973                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0037 L22:   0.0045                                     
REMARK   3      L33:   0.0231 L12:   0.0049                                     
REMARK   3      L13:  -0.0083 L23:  -0.0097                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1139 S12:  -0.0147 S13:  -0.0174                       
REMARK   3      S21:   0.1277 S22:  -0.0515 S23:  -0.0790                       
REMARK   3      S31:   0.0945 S32:   0.0863 S33:   0.0000                       
REMARK   3   TLS GROUP : 19                                                     
REMARK   3    SELECTION: (chain I and resid 80:118)                             
REMARK   3    ORIGIN FOR THE GROUP (A): 228.7984  64.0571  11.0577              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3076 T22:   0.4192                                     
REMARK   3      T33:   0.1516 T12:  -0.1572                                     
REMARK   3      T13:   0.0938 T23:   0.0941                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0300 L22:   0.0391                                     
REMARK   3      L33:   0.0187 L12:   0.0339                                     
REMARK   3      L13:  -0.0261 L23:  -0.0285                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0162 S12:   0.0700 S13:   0.0954                       
REMARK   3      S21:   0.0109 S22:  -0.0088 S23:  -0.0254                       
REMARK   3      S31:  -0.0267 S32:   0.1057 S33:  -0.0222                       
REMARK   3   TLS GROUP : 20                                                     
REMARK   3    SELECTION: (chain I and resid 119:156)                            
REMARK   3    ORIGIN FOR THE GROUP (A): 226.1755  59.7648  12.8542              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2917 T22:   0.3110                                     
REMARK   3      T33:   0.2181 T12:  -0.0191                                     
REMARK   3      T13:   0.0818 T23:   0.0190                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0075 L22:   0.0115                                     
REMARK   3      L33:   0.0088 L12:   0.0009                                     
REMARK   3      L13:  -0.0072 L23:  -0.0075                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0209 S12:   0.0501 S13:  -0.0120                       
REMARK   3      S21:  -0.0395 S22:  -0.0259 S23:  -0.0308                       
REMARK   3      S31:  -0.0347 S32:   0.1402 S33:  -0.0000                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: HYDROGENS HAVE BEEN ADDED IN THE RIDING   
REMARK   3  POSITIONS                                                           
REMARK   4                                                                      
REMARK   4 4HR7 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 13-NOV-12.                  
REMARK 100 THE RCSB ID CODE IS RCSB075818.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 08-JUL-12                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 6.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 24-ID-E                            
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.98                               
REMARK 200  MONOCHROMATOR                  : CRYOGENICALLY-COOLED SINGLE        
REMARK 200                                   CRYSTAL SI(220) SIDE BOUNCE        
REMARK 200  OPTICS                         : KB MIRRORS                         
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315                   
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : XDS                                
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 79251                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.490                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 104.300                            
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.6                               
REMARK 200  DATA REDUNDANCY                : 2.500                              
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : 0.06200                            
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 11.2000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.49                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.63                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 95.4                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.50                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : 0.33100                            
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 2.400                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: PDB ENTRIES 1DV1 AND 1BDO                            
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 42.63                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.14                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.2 M AMMONIUM SULFATE, 0.1 M BIS-       
REMARK 280  TRIS, PH 6.5, 25% PEG3350, VAPOR DIFFUSION, SITTING DROP,           
REMARK 280  TEMPERATURE 295.15K                                                 
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1                          
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y,-Z                                                 
REMARK 290       3555   X+1/2,Y+1/2,Z                                           
REMARK 290       4555   -X+1/2,Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000      116.49750            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       48.19250            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000      116.49750            
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       48.19250            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 300 REMARK: QUATERNARY STRUCTURE IS AN (ALPHA)4(BETA)4 HETEROOCTAMER.    
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTAMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: OCTAMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 15930 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 78320 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -245.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, I, E, B, C, G, F, D                
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     GLY A   164                                                      
REMARK 465     GLY A   165                                                      
REMARK 465     GLY A   166                                                      
REMARK 465     GLN A   447                                                      
REMARK 465     GLU A   448                                                      
REMARK 465     LYS A   449                                                      
REMARK 465     MET B   -19                                                      
REMARK 465     GLY B   -18                                                      
REMARK 465     SER B   -17                                                      
REMARK 465     SER B   -16                                                      
REMARK 465     HIS B   -15                                                      
REMARK 465     HIS B   -14                                                      
REMARK 465     HIS B   -13                                                      
REMARK 465     HIS B   -12                                                      
REMARK 465     HIS B   -11                                                      
REMARK 465     HIS B   -10                                                      
REMARK 465     SER B    -9                                                      
REMARK 465     SER B    -8                                                      
REMARK 465     GLY B    -7                                                      
REMARK 465     LEU B    -6                                                      
REMARK 465     VAL B    -5                                                      
REMARK 465     PRO B    -4                                                      
REMARK 465     ARG B    -3                                                      
REMARK 465     GLY B    -2                                                      
REMARK 465     SER B    -1                                                      
REMARK 465     HIS B     0                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ASP B     2                                                      
REMARK 465     ILE B     3                                                      
REMARK 465     ARG B     4                                                      
REMARK 465     LYS B     5                                                      
REMARK 465     ILE B     6                                                      
REMARK 465     LYS B     7                                                      
REMARK 465     LYS B     8                                                      
REMARK 465     LEU B     9                                                      
REMARK 465     ILE B    10                                                      
REMARK 465     GLU B    11                                                      
REMARK 465     LEU B    12                                                      
REMARK 465     VAL B    13                                                      
REMARK 465     GLU B    14                                                      
REMARK 465     GLU B    15                                                      
REMARK 465     SER B    16                                                      
REMARK 465     GLY B    17                                                      
REMARK 465     ILE B    18                                                      
REMARK 465     SER B    19                                                      
REMARK 465     GLU B    20                                                      
REMARK 465     LEU B    21                                                      
REMARK 465     GLU B    22                                                      
REMARK 465     ILE B    23                                                      
REMARK 465     SER B    24                                                      
REMARK 465     GLU B    25                                                      
REMARK 465     GLY B    26                                                      
REMARK 465     GLU B    27                                                      
REMARK 465     GLU B    28                                                      
REMARK 465     SER B    29                                                      
REMARK 465     VAL B    30                                                      
REMARK 465     ARG B    31                                                      
REMARK 465     ILE B    32                                                      
REMARK 465     SER B    33                                                      
REMARK 465     ARG B    34                                                      
REMARK 465     ALA B    35                                                      
REMARK 465     ALA B    36                                                      
REMARK 465     PRO B    37                                                      
REMARK 465     ALA B    38                                                      
REMARK 465     ALA B    39                                                      
REMARK 465     SER B    40                                                      
REMARK 465     PHE B    41                                                      
REMARK 465     PRO B    42                                                      
REMARK 465     VAL B    43                                                      
REMARK 465     MET B    44                                                      
REMARK 465     GLN B    45                                                      
REMARK 465     GLN B    46                                                      
REMARK 465     ALA B    47                                                      
REMARK 465     TYR B    48                                                      
REMARK 465     ALA B    49                                                      
REMARK 465     ALA B    50                                                      
REMARK 465     PRO B    51                                                      
REMARK 465     MET B    52                                                      
REMARK 465     MET B    53                                                      
REMARK 465     GLN B    54                                                      
REMARK 465     GLN B    55                                                      
REMARK 465     PRO B    56                                                      
REMARK 465     ALA B    57                                                      
REMARK 465     GLN B    58                                                      
REMARK 465     SER B    59                                                      
REMARK 465     ASN B    60                                                      
REMARK 465     ALA B    61                                                      
REMARK 465     ALA B    62                                                      
REMARK 465     ALA B    63                                                      
REMARK 465     PRO B    64                                                      
REMARK 465     ALA B    65                                                      
REMARK 465     THR B    66                                                      
REMARK 465     VAL B    67                                                      
REMARK 465     PRO B    68                                                      
REMARK 465     SER B    69                                                      
REMARK 465     MET B    70                                                      
REMARK 465     GLU B    71                                                      
REMARK 465     ALA B    72                                                      
REMARK 465     PRO B    73                                                      
REMARK 465     ALA B    74                                                      
REMARK 465     ALA B    75                                                      
REMARK 465     ALA B    76                                                      
REMARK 465     GLY C   162                                                      
REMARK 465     GLY C   163                                                      
REMARK 465     GLY C   164                                                      
REMARK 465     GLY C   165                                                      
REMARK 465     GLY C   166                                                      
REMARK 465     ARG C   167                                                      
REMARK 465     GLY C   168                                                      
REMARK 465     MET C   169                                                      
REMARK 465     SER C   183                                                      
REMARK 465     MET C   184                                                      
REMARK 465     THR C   185                                                      
REMARK 465     ARG C   186                                                      
REMARK 465     ALA C   187                                                      
REMARK 465     GLU C   188                                                      
REMARK 465     ALA C   189                                                      
REMARK 465     LYS C   190                                                      
REMARK 465     ALA C   191                                                      
REMARK 465     ALA C   192                                                      
REMARK 465     PHE C   193                                                      
REMARK 465     SER C   194                                                      
REMARK 465     ASN C   195                                                      
REMARK 465     GLN C   447                                                      
REMARK 465     GLU C   448                                                      
REMARK 465     LYS C   449                                                      
REMARK 465     MET D   -19                                                      
REMARK 465     GLY D   -18                                                      
REMARK 465     SER D   -17                                                      
REMARK 465     SER D   -16                                                      
REMARK 465     HIS D   -15                                                      
REMARK 465     HIS D   -14                                                      
REMARK 465     HIS D   -13                                                      
REMARK 465     HIS D   -12                                                      
REMARK 465     HIS D   -11                                                      
REMARK 465     HIS D   -10                                                      
REMARK 465     SER D    -9                                                      
REMARK 465     SER D    -8                                                      
REMARK 465     GLY D    -7                                                      
REMARK 465     LEU D    -6                                                      
REMARK 465     VAL D    -5                                                      
REMARK 465     PRO D    -4                                                      
REMARK 465     ARG D    -3                                                      
REMARK 465     GLY D    -2                                                      
REMARK 465     SER D    -1                                                      
REMARK 465     HIS D     0                                                      
REMARK 465     MET D     1                                                      
REMARK 465     ASP D     2                                                      
REMARK 465     ILE D     3                                                      
REMARK 465     ARG D     4                                                      
REMARK 465     LYS D     5                                                      
REMARK 465     ILE D     6                                                      
REMARK 465     LYS D     7                                                      
REMARK 465     LYS D     8                                                      
REMARK 465     LEU D     9                                                      
REMARK 465     ILE D    10                                                      
REMARK 465     GLU D    11                                                      
REMARK 465     LEU D    12                                                      
REMARK 465     VAL D    13                                                      
REMARK 465     GLU D    14                                                      
REMARK 465     GLU D    15                                                      
REMARK 465     SER D    16                                                      
REMARK 465     GLY D    17                                                      
REMARK 465     ILE D    18                                                      
REMARK 465     SER D    19                                                      
REMARK 465     GLU D    20                                                      
REMARK 465     LEU D    21                                                      
REMARK 465     GLU D    22                                                      
REMARK 465     ILE D    23                                                      
REMARK 465     SER D    24                                                      
REMARK 465     GLU D    25                                                      
REMARK 465     GLY D    26                                                      
REMARK 465     GLU D    27                                                      
REMARK 465     GLU D    28                                                      
REMARK 465     SER D    29                                                      
REMARK 465     VAL D    30                                                      
REMARK 465     ARG D    31                                                      
REMARK 465     ILE D    32                                                      
REMARK 465     SER D    33                                                      
REMARK 465     ARG D    34                                                      
REMARK 465     ALA D    35                                                      
REMARK 465     ALA D    36                                                      
REMARK 465     PRO D    37                                                      
REMARK 465     ALA D    38                                                      
REMARK 465     ALA D    39                                                      
REMARK 465     SER D    40                                                      
REMARK 465     PHE D    41                                                      
REMARK 465     PRO D    42                                                      
REMARK 465     VAL D    43                                                      
REMARK 465     MET D    44                                                      
REMARK 465     GLN D    45                                                      
REMARK 465     GLN D    46                                                      
REMARK 465     ALA D    47                                                      
REMARK 465     TYR D    48                                                      
REMARK 465     ALA D    49                                                      
REMARK 465     ALA D    50                                                      
REMARK 465     PRO D    51                                                      
REMARK 465     MET D    52                                                      
REMARK 465     MET D    53                                                      
REMARK 465     GLN D    54                                                      
REMARK 465     GLN D    55                                                      
REMARK 465     PRO D    56                                                      
REMARK 465     ALA D    57                                                      
REMARK 465     GLN D    58                                                      
REMARK 465     SER D    59                                                      
REMARK 465     ASN D    60                                                      
REMARK 465     ALA D    61                                                      
REMARK 465     ALA D    62                                                      
REMARK 465     ALA D    63                                                      
REMARK 465     PRO D    64                                                      
REMARK 465     ALA D    65                                                      
REMARK 465     THR D    66                                                      
REMARK 465     VAL D    67                                                      
REMARK 465     PRO D    68                                                      
REMARK 465     SER D    69                                                      
REMARK 465     MET D    70                                                      
REMARK 465     GLU D    71                                                      
REMARK 465     ALA D    72                                                      
REMARK 465     PRO D    73                                                      
REMARK 465     ALA D    74                                                      
REMARK 465     ALA D    75                                                      
REMARK 465     ALA D    76                                                      
REMARK 465     GLU D    77                                                      
REMARK 465     ILE D    78                                                      
REMARK 465     ALA E   160                                                      
REMARK 465     SER E   161                                                      
REMARK 465     GLY E   162                                                      
REMARK 465     GLY E   163                                                      
REMARK 465     GLY E   164                                                      
REMARK 465     GLY E   165                                                      
REMARK 465     GLY E   166                                                      
REMARK 465     ARG E   167                                                      
REMARK 465     GLY E   168                                                      
REMARK 465     MET E   169                                                      
REMARK 465     MET E   184                                                      
REMARK 465     THR E   185                                                      
REMARK 465     ARG E   186                                                      
REMARK 465     ALA E   187                                                      
REMARK 465     GLU E   188                                                      
REMARK 465     ALA E   189                                                      
REMARK 465     LYS E   190                                                      
REMARK 465     ALA E   191                                                      
REMARK 465     ALA E   192                                                      
REMARK 465     PHE E   193                                                      
REMARK 465     SER E   194                                                      
REMARK 465     ASN E   195                                                      
REMARK 465     ASP E   196                                                      
REMARK 465     GLN E   447                                                      
REMARK 465     GLU E   448                                                      
REMARK 465     LYS E   449                                                      
REMARK 465     SER F   161                                                      
REMARK 465     GLY F   162                                                      
REMARK 465     GLY F   163                                                      
REMARK 465     GLY F   164                                                      
REMARK 465     GLY F   165                                                      
REMARK 465     GLY F   166                                                      
REMARK 465     ARG F   167                                                      
REMARK 465     GLY F   168                                                      
REMARK 465     THR F   185                                                      
REMARK 465     ARG F   186                                                      
REMARK 465     ALA F   187                                                      
REMARK 465     GLU F   188                                                      
REMARK 465     ALA F   189                                                      
REMARK 465     LYS F   190                                                      
REMARK 465     ALA F   191                                                      
REMARK 465     ALA F   192                                                      
REMARK 465     PHE F   193                                                      
REMARK 465     SER F   194                                                      
REMARK 465     ASN F   195                                                      
REMARK 465     GLN F   447                                                      
REMARK 465     GLU F   448                                                      
REMARK 465     LYS F   449                                                      
REMARK 465     MET G   -19                                                      
REMARK 465     GLY G   -18                                                      
REMARK 465     SER G   -17                                                      
REMARK 465     SER G   -16                                                      
REMARK 465     HIS G   -15                                                      
REMARK 465     HIS G   -14                                                      
REMARK 465     HIS G   -13                                                      
REMARK 465     HIS G   -12                                                      
REMARK 465     HIS G   -11                                                      
REMARK 465     HIS G   -10                                                      
REMARK 465     SER G    -9                                                      
REMARK 465     SER G    -8                                                      
REMARK 465     GLY G    -7                                                      
REMARK 465     LEU G    -6                                                      
REMARK 465     VAL G    -5                                                      
REMARK 465     PRO G    -4                                                      
REMARK 465     ARG G    -3                                                      
REMARK 465     GLY G    -2                                                      
REMARK 465     SER G    -1                                                      
REMARK 465     HIS G     0                                                      
REMARK 465     MET G     1                                                      
REMARK 465     ASP G     2                                                      
REMARK 465     ILE G     3                                                      
REMARK 465     ARG G     4                                                      
REMARK 465     LYS G     5                                                      
REMARK 465     ILE G     6                                                      
REMARK 465     LYS G     7                                                      
REMARK 465     LYS G     8                                                      
REMARK 465     LEU G     9                                                      
REMARK 465     ILE G    10                                                      
REMARK 465     GLU G    11                                                      
REMARK 465     LEU G    12                                                      
REMARK 465     VAL G    13                                                      
REMARK 465     GLU G    14                                                      
REMARK 465     GLU G    15                                                      
REMARK 465     SER G    16                                                      
REMARK 465     GLY G    17                                                      
REMARK 465     ILE G    18                                                      
REMARK 465     SER G    19                                                      
REMARK 465     GLU G    20                                                      
REMARK 465     LEU G    21                                                      
REMARK 465     GLU G    22                                                      
REMARK 465     ILE G    23                                                      
REMARK 465     SER G    24                                                      
REMARK 465     GLU G    25                                                      
REMARK 465     GLY G    26                                                      
REMARK 465     GLU G    27                                                      
REMARK 465     GLU G    28                                                      
REMARK 465     SER G    29                                                      
REMARK 465     VAL G    30                                                      
REMARK 465     ARG G    31                                                      
REMARK 465     ILE G    32                                                      
REMARK 465     SER G    33                                                      
REMARK 465     ARG G    34                                                      
REMARK 465     ALA G    35                                                      
REMARK 465     ALA G    36                                                      
REMARK 465     PRO G    37                                                      
REMARK 465     ALA G    38                                                      
REMARK 465     ALA G    39                                                      
REMARK 465     SER G    40                                                      
REMARK 465     PHE G    41                                                      
REMARK 465     PRO G    42                                                      
REMARK 465     VAL G    43                                                      
REMARK 465     MET G    44                                                      
REMARK 465     GLN G    45                                                      
REMARK 465     GLN G    46                                                      
REMARK 465     ALA G    47                                                      
REMARK 465     TYR G    48                                                      
REMARK 465     ALA G    49                                                      
REMARK 465     ALA G    50                                                      
REMARK 465     PRO G    51                                                      
REMARK 465     MET G    52                                                      
REMARK 465     MET G    53                                                      
REMARK 465     GLN G    54                                                      
REMARK 465     GLN G    55                                                      
REMARK 465     PRO G    56                                                      
REMARK 465     ALA G    57                                                      
REMARK 465     GLN G    58                                                      
REMARK 465     SER G    59                                                      
REMARK 465     ASN G    60                                                      
REMARK 465     ALA G    61                                                      
REMARK 465     ALA G    62                                                      
REMARK 465     ALA G    63                                                      
REMARK 465     PRO G    64                                                      
REMARK 465     ALA G    65                                                      
REMARK 465     THR G    66                                                      
REMARK 465     VAL G    67                                                      
REMARK 465     PRO G    68                                                      
REMARK 465     SER G    69                                                      
REMARK 465     MET G    70                                                      
REMARK 465     GLU G    71                                                      
REMARK 465     ALA G    72                                                      
REMARK 465     PRO G    73                                                      
REMARK 465     ALA G    74                                                      
REMARK 465     ALA G    75                                                      
REMARK 465     ALA G    76                                                      
REMARK 465     GLU G    77                                                      
REMARK 465     ILE G    78                                                      
REMARK 465     SER G    79                                                      
REMARK 465     MET I   -19                                                      
REMARK 465     GLY I   -18                                                      
REMARK 465     SER I   -17                                                      
REMARK 465     SER I   -16                                                      
REMARK 465     HIS I   -15                                                      
REMARK 465     HIS I   -14                                                      
REMARK 465     HIS I   -13                                                      
REMARK 465     HIS I   -12                                                      
REMARK 465     HIS I   -11                                                      
REMARK 465     HIS I   -10                                                      
REMARK 465     SER I    -9                                                      
REMARK 465     SER I    -8                                                      
REMARK 465     GLY I    -7                                                      
REMARK 465     LEU I    -6                                                      
REMARK 465     VAL I    -5                                                      
REMARK 465     PRO I    -4                                                      
REMARK 465     ARG I    -3                                                      
REMARK 465     GLY I    -2                                                      
REMARK 465     SER I    -1                                                      
REMARK 465     HIS I     0                                                      
REMARK 465     MET I     1                                                      
REMARK 465     ASP I     2                                                      
REMARK 465     ILE I     3                                                      
REMARK 465     ARG I     4                                                      
REMARK 465     LYS I     5                                                      
REMARK 465     ILE I     6                                                      
REMARK 465     LYS I     7                                                      
REMARK 465     LYS I     8                                                      
REMARK 465     LEU I     9                                                      
REMARK 465     ILE I    10                                                      
REMARK 465     GLU I    11                                                      
REMARK 465     LEU I    12                                                      
REMARK 465     VAL I    13                                                      
REMARK 465     GLU I    14                                                      
REMARK 465     GLU I    15                                                      
REMARK 465     SER I    16                                                      
REMARK 465     GLY I    17                                                      
REMARK 465     ILE I    18                                                      
REMARK 465     SER I    19                                                      
REMARK 465     GLU I    20                                                      
REMARK 465     LEU I    21                                                      
REMARK 465     GLU I    22                                                      
REMARK 465     ILE I    23                                                      
REMARK 465     SER I    24                                                      
REMARK 465     GLU I    25                                                      
REMARK 465     GLY I    26                                                      
REMARK 465     GLU I    27                                                      
REMARK 465     GLU I    28                                                      
REMARK 465     SER I    29                                                      
REMARK 465     VAL I    30                                                      
REMARK 465     ARG I    31                                                      
REMARK 465     ILE I    32                                                      
REMARK 465     SER I    33                                                      
REMARK 465     ARG I    34                                                      
REMARK 465     ALA I    35                                                      
REMARK 465     ALA I    36                                                      
REMARK 465     PRO I    37                                                      
REMARK 465     ALA I    38                                                      
REMARK 465     ALA I    39                                                      
REMARK 465     SER I    40                                                      
REMARK 465     PHE I    41                                                      
REMARK 465     PRO I    42                                                      
REMARK 465     VAL I    43                                                      
REMARK 465     MET I    44                                                      
REMARK 465     GLN I    45                                                      
REMARK 465     GLN I    46                                                      
REMARK 465     ALA I    47                                                      
REMARK 465     TYR I    48                                                      
REMARK 465     ALA I    49                                                      
REMARK 465     ALA I    50                                                      
REMARK 465     PRO I    51                                                      
REMARK 465     MET I    52                                                      
REMARK 465     MET I    53                                                      
REMARK 465     GLN I    54                                                      
REMARK 465     GLN I    55                                                      
REMARK 465     PRO I    56                                                      
REMARK 465     ALA I    57                                                      
REMARK 465     GLN I    58                                                      
REMARK 465     SER I    59                                                      
REMARK 465     ASN I    60                                                      
REMARK 465     ALA I    61                                                      
REMARK 465     ALA I    62                                                      
REMARK 465     ALA I    63                                                      
REMARK 465     PRO I    64                                                      
REMARK 465     ALA I    65                                                      
REMARK 465     THR I    66                                                      
REMARK 465     VAL I    67                                                      
REMARK 465     PRO I    68                                                      
REMARK 465     SER I    69                                                      
REMARK 465     MET I    70                                                      
REMARK 465     GLU I    71                                                      
REMARK 465     ALA I    72                                                      
REMARK 465     PRO I    73                                                      
REMARK 465     ALA I    74                                                      
REMARK 465     ALA I    75                                                      
REMARK 465     ALA I    76                                                      
REMARK 465     GLU I    77                                                      
REMARK 465     ILE I    78                                                      
REMARK 465     SER I    79                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LYS A 144    CG   CD   CE   NZ                                   
REMARK 470     PHE A 193    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     MET A 197    CG   SD   CE                                        
REMARK 470     SER B  79    OG                                                  
REMARK 470     ASP B  98    CG   OD1  OD2                                       
REMARK 470     LYS D 108    CG   CD   CE   NZ                                   
REMARK 470     LYS D 131    CG   CD   CE   NZ                                   
REMARK 470     GLU E  96    CG   CD   OE1  OE2                                  
REMARK 470     ASP E 140    CG   OD1  OD2                                       
REMARK 470     MET E 197    CG   SD   CE                                        
REMARK 470     MET F 169    CG   SD   CE                                        
REMARK 470     TYR F 199    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS G 108    CG   CD   CE   NZ                                   
REMARK 470     GLU G 156    CG   CD   OE1  OE2                                  
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OH   TYR A   375     O1   SO4 A   505              2.01            
REMARK 500   OE1  GLU I   119     O    HOH I   207              2.05            
REMARK 500   O    HOH E   663     O    HOH E   665              2.10            
REMARK 500   OD1  ASP F   143     NH2  ARG F   146              2.18            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS                                             
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC             
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15          
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A           
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375             
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE               
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.            
REMARK 500                                                                      
REMARK 500 DISTANCE CUTOFF:                                                     
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS              
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS                  
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE          
REMARK 500   NZ   LYS B   100     NZ   LYS B   100     2756     1.80            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASN A   9     -169.01   -169.44                                   
REMARK 500    SER A  59      -83.25   -125.88                                   
REMARK 500    PHE A  84     -112.56     43.98                                   
REMARK 500    ALA A 192      -68.18   -103.85                                   
REMARK 500    ASN A 206       71.52   -119.03                                   
REMARK 500    LEU A 225       68.69   -114.01                                   
REMARK 500    ALA A 226     -164.65     54.25                                   
REMARK 500    PRO A 379       40.93    -80.48                                   
REMARK 500    TYR A 381      170.64     75.25                                   
REMARK 500    CYS B 116     -176.52   -170.50                                   
REMARK 500    LYS B 122       -6.42     67.58                                   
REMARK 500    ASN C   9     -169.36   -168.76                                   
REMARK 500    SER C  59      -82.53   -127.20                                   
REMARK 500    PHE C  84     -113.18     44.22                                   
REMARK 500    LEU C 225       70.23   -114.47                                   
REMARK 500    ALA C 226     -164.20     54.81                                   
REMARK 500    PRO C 379       40.30    -80.09                                   
REMARK 500    TYR C 381      169.58     75.98                                   
REMARK 500    CYS D 116     -177.74   -170.28                                   
REMARK 500    MET D 121     -153.15     60.00                                   
REMARK 500    ASN E   9     -168.60   -167.56                                   
REMARK 500    SER E  59      -82.72   -126.06                                   
REMARK 500    PHE E  84     -112.55     43.43                                   
REMARK 500    LEU E 225       69.67   -114.60                                   
REMARK 500    ALA E 226     -164.86     54.13                                   
REMARK 500    ARG E 292      172.27    179.75                                   
REMARK 500    PRO E 379       40.23    -80.03                                   
REMARK 500    TYR E 381      171.94     74.80                                   
REMARK 500    ASN F   9     -169.47   -169.13                                   
REMARK 500    SER F  59      -82.12   -124.87                                   
REMARK 500    PHE F  84     -113.43     44.04                                   
REMARK 500    LEU F 225       70.73   -113.24                                   
REMARK 500    ALA F 226     -165.23     54.54                                   
REMARK 500    ARG F 292      172.25    179.28                                   
REMARK 500    PRO F 379       41.63    -80.07                                   
REMARK 500    TYR F 381      170.85     74.02                                   
REMARK 500    LYS G 122       -7.20     73.85                                   
REMARK 500    LYS I 122       -8.69     73.51                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 502                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 503                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 504                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 505                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 C 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 C 502                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE EDO C 503                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 E 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 E 502                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 E 503                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 F 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 F 502                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 1DV1   RELATED DB: PDB                                   
REMARK 900 BIOTIN CARBOXYLASE                                                   
REMARK 900 RELATED ID: 1BDO   RELATED DB: PDB                                   
REMARK 900 BIOTIN CARBOXYL CARRIER PROTEIN                                      
DBREF  4HR7 A    1   449  UNP    P24182   ACCC_ECOLI       1    449             
DBREF  4HR7 B    1   156  UNP    P0ABD8   BCCP_ECOLI       1    156             
DBREF  4HR7 C    1   449  UNP    P24182   ACCC_ECOLI       1    449             
DBREF  4HR7 D    1   156  UNP    P0ABD8   BCCP_ECOLI       1    156             
DBREF  4HR7 E    1   449  UNP    P24182   ACCC_ECOLI       1    449             
DBREF  4HR7 F    1   449  UNP    P24182   ACCC_ECOLI       1    449             
DBREF  4HR7 G    1   156  UNP    P0ABD8   BCCP_ECOLI       1    156             
DBREF  4HR7 I    1   156  UNP    P0ABD8   BCCP_ECOLI       1    156             
SEQADV 4HR7 MET B  -19  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 GLY B  -18  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER B  -17  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER B  -16  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS B  -15  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS B  -14  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS B  -13  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS B  -12  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS B  -11  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS B  -10  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER B   -9  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER B   -8  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 GLY B   -7  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 LEU B   -6  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 VAL B   -5  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 PRO B   -4  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 ARG B   -3  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 GLY B   -2  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER B   -1  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS B    0  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 MET D  -19  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 GLY D  -18  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER D  -17  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER D  -16  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS D  -15  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS D  -14  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS D  -13  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS D  -12  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS D  -11  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS D  -10  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER D   -9  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER D   -8  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 GLY D   -7  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 LEU D   -6  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 VAL D   -5  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 PRO D   -4  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 ARG D   -3  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 GLY D   -2  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER D   -1  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS D    0  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 MET G  -19  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 GLY G  -18  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER G  -17  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER G  -16  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS G  -15  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS G  -14  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS G  -13  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS G  -12  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS G  -11  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS G  -10  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER G   -9  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER G   -8  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 GLY G   -7  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 LEU G   -6  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 VAL G   -5  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 PRO G   -4  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 ARG G   -3  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 GLY G   -2  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER G   -1  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS G    0  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 MET I  -19  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 GLY I  -18  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER I  -17  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER I  -16  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS I  -15  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS I  -14  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS I  -13  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS I  -12  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS I  -11  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS I  -10  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER I   -9  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER I   -8  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 GLY I   -7  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 LEU I   -6  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 VAL I   -5  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 PRO I   -4  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 ARG I   -3  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 GLY I   -2  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 SER I   -1  UNP  P0ABD8              EXPRESSION TAG                 
SEQADV 4HR7 HIS I    0  UNP  P0ABD8              EXPRESSION TAG                 
SEQRES   1 A  449  MET LEU ASP LYS ILE VAL ILE ALA ASN ARG GLY GLU ILE          
SEQRES   2 A  449  ALA LEU ARG ILE LEU ARG ALA CYS LYS GLU LEU GLY ILE          
SEQRES   3 A  449  LYS THR VAL ALA VAL HIS SER SER ALA ASP ARG ASP LEU          
SEQRES   4 A  449  LYS HIS VAL LEU LEU ALA ASP GLU THR VAL CYS ILE GLY          
SEQRES   5 A  449  PRO ALA PRO SER VAL LYS SER TYR LEU ASN ILE PRO ALA          
SEQRES   6 A  449  ILE ILE SER ALA ALA GLU ILE THR GLY ALA VAL ALA ILE          
SEQRES   7 A  449  HIS PRO GLY TYR GLY PHE LEU SER GLU ASN ALA ASN PHE          
SEQRES   8 A  449  ALA GLU GLN VAL GLU ARG SER GLY PHE ILE PHE ILE GLY          
SEQRES   9 A  449  PRO LYS ALA GLU THR ILE ARG LEU MET GLY ASP LYS VAL          
SEQRES  10 A  449  SER ALA ILE ALA ALA MET LYS LYS ALA GLY VAL PRO CYS          
SEQRES  11 A  449  VAL PRO GLY SER ASP GLY PRO LEU GLY ASP ASP MET ASP          
SEQRES  12 A  449  LYS ASN ARG ALA ILE ALA LYS ARG ILE GLY TYR PRO VAL          
SEQRES  13 A  449  ILE ILE LYS ALA SER GLY GLY GLY GLY GLY ARG GLY MET          
SEQRES  14 A  449  ARG VAL VAL ARG GLY ASP ALA GLU LEU ALA GLN SER ILE          
SEQRES  15 A  449  SER MET THR ARG ALA GLU ALA LYS ALA ALA PHE SER ASN          
SEQRES  16 A  449  ASP MET VAL TYR MET GLU LYS TYR LEU GLU ASN PRO ARG          
SEQRES  17 A  449  HIS VAL GLU ILE GLN VAL LEU ALA ASP GLY GLN GLY ASN          
SEQRES  18 A  449  ALA ILE TYR LEU ALA GLU ARG ASP CYS SER MET GLN ARG          
SEQRES  19 A  449  ARG HIS GLN LYS VAL VAL GLU GLU ALA PRO ALA PRO GLY          
SEQRES  20 A  449  ILE THR PRO GLU LEU ARG ARG TYR ILE GLY GLU ARG CYS          
SEQRES  21 A  449  ALA LYS ALA CYS VAL ASP ILE GLY TYR ARG GLY ALA GLY          
SEQRES  22 A  449  THR PHE GLU PHE LEU PHE GLU ASN GLY GLU PHE TYR PHE          
SEQRES  23 A  449  ILE GLU MET ASN THR ARG ILE GLN VAL GLU HIS PRO VAL          
SEQRES  24 A  449  THR GLU MET ILE THR GLY VAL ASP LEU ILE LYS GLU GLN          
SEQRES  25 A  449  LEU ARG ILE ALA ALA GLY GLN PRO LEU SER ILE LYS GLN          
SEQRES  26 A  449  GLU GLU VAL HIS VAL ARG GLY HIS ALA VAL GLU CYS ARG          
SEQRES  27 A  449  ILE ASN ALA GLU ASP PRO ASN THR PHE LEU PRO SER PRO          
SEQRES  28 A  449  GLY LYS ILE THR ARG PHE HIS ALA PRO GLY GLY PHE GLY          
SEQRES  29 A  449  VAL ARG TRP GLU SER HIS ILE TYR ALA GLY TYR THR VAL          
SEQRES  30 A  449  PRO PRO TYR TYR ASP SER MET ILE GLY LYS LEU ILE CYS          
SEQRES  31 A  449  TYR GLY GLU ASN ARG ASP VAL ALA ILE ALA ARG MET LYS          
SEQRES  32 A  449  ASN ALA LEU GLN GLU LEU ILE ILE ASP GLY ILE LYS THR          
SEQRES  33 A  449  ASN VAL ASP LEU GLN ILE ARG ILE MET ASN ASP GLU ASN          
SEQRES  34 A  449  PHE GLN HIS GLY GLY THR ASN ILE HIS TYR LEU GLU LYS          
SEQRES  35 A  449  LYS LEU GLY LEU GLN GLU LYS                                  
SEQRES   1 B  176  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 B  176  LEU VAL PRO ARG GLY SER HIS MET ASP ILE ARG LYS ILE          
SEQRES   3 B  176  LYS LYS LEU ILE GLU LEU VAL GLU GLU SER GLY ILE SER          
SEQRES   4 B  176  GLU LEU GLU ILE SER GLU GLY GLU GLU SER VAL ARG ILE          
SEQRES   5 B  176  SER ARG ALA ALA PRO ALA ALA SER PHE PRO VAL MET GLN          
SEQRES   6 B  176  GLN ALA TYR ALA ALA PRO MET MET GLN GLN PRO ALA GLN          
SEQRES   7 B  176  SER ASN ALA ALA ALA PRO ALA THR VAL PRO SER MET GLU          
SEQRES   8 B  176  ALA PRO ALA ALA ALA GLU ILE SER GLY HIS ILE VAL ARG          
SEQRES   9 B  176  SER PRO MET VAL GLY THR PHE TYR ARG THR PRO SER PRO          
SEQRES  10 B  176  ASP ALA LYS ALA PHE ILE GLU VAL GLY GLN LYS VAL ASN          
SEQRES  11 B  176  VAL GLY ASP THR LEU CYS ILE VAL GLU ALA MET LYS MET          
SEQRES  12 B  176  MET ASN GLN ILE GLU ALA ASP LYS SER GLY THR VAL LYS          
SEQRES  13 B  176  ALA ILE LEU VAL GLU SER GLY GLN PRO VAL GLU PHE ASP          
SEQRES  14 B  176  GLU PRO LEU VAL VAL ILE GLU                                  
SEQRES   1 C  449  MET LEU ASP LYS ILE VAL ILE ALA ASN ARG GLY GLU ILE          
SEQRES   2 C  449  ALA LEU ARG ILE LEU ARG ALA CYS LYS GLU LEU GLY ILE          
SEQRES   3 C  449  LYS THR VAL ALA VAL HIS SER SER ALA ASP ARG ASP LEU          
SEQRES   4 C  449  LYS HIS VAL LEU LEU ALA ASP GLU THR VAL CYS ILE GLY          
SEQRES   5 C  449  PRO ALA PRO SER VAL LYS SER TYR LEU ASN ILE PRO ALA          
SEQRES   6 C  449  ILE ILE SER ALA ALA GLU ILE THR GLY ALA VAL ALA ILE          
SEQRES   7 C  449  HIS PRO GLY TYR GLY PHE LEU SER GLU ASN ALA ASN PHE          
SEQRES   8 C  449  ALA GLU GLN VAL GLU ARG SER GLY PHE ILE PHE ILE GLY          
SEQRES   9 C  449  PRO LYS ALA GLU THR ILE ARG LEU MET GLY ASP LYS VAL          
SEQRES  10 C  449  SER ALA ILE ALA ALA MET LYS LYS ALA GLY VAL PRO CYS          
SEQRES  11 C  449  VAL PRO GLY SER ASP GLY PRO LEU GLY ASP ASP MET ASP          
SEQRES  12 C  449  LYS ASN ARG ALA ILE ALA LYS ARG ILE GLY TYR PRO VAL          
SEQRES  13 C  449  ILE ILE LYS ALA SER GLY GLY GLY GLY GLY ARG GLY MET          
SEQRES  14 C  449  ARG VAL VAL ARG GLY ASP ALA GLU LEU ALA GLN SER ILE          
SEQRES  15 C  449  SER MET THR ARG ALA GLU ALA LYS ALA ALA PHE SER ASN          
SEQRES  16 C  449  ASP MET VAL TYR MET GLU LYS TYR LEU GLU ASN PRO ARG          
SEQRES  17 C  449  HIS VAL GLU ILE GLN VAL LEU ALA ASP GLY GLN GLY ASN          
SEQRES  18 C  449  ALA ILE TYR LEU ALA GLU ARG ASP CYS SER MET GLN ARG          
SEQRES  19 C  449  ARG HIS GLN LYS VAL VAL GLU GLU ALA PRO ALA PRO GLY          
SEQRES  20 C  449  ILE THR PRO GLU LEU ARG ARG TYR ILE GLY GLU ARG CYS          
SEQRES  21 C  449  ALA LYS ALA CYS VAL ASP ILE GLY TYR ARG GLY ALA GLY          
SEQRES  22 C  449  THR PHE GLU PHE LEU PHE GLU ASN GLY GLU PHE TYR PHE          
SEQRES  23 C  449  ILE GLU MET ASN THR ARG ILE GLN VAL GLU HIS PRO VAL          
SEQRES  24 C  449  THR GLU MET ILE THR GLY VAL ASP LEU ILE LYS GLU GLN          
SEQRES  25 C  449  LEU ARG ILE ALA ALA GLY GLN PRO LEU SER ILE LYS GLN          
SEQRES  26 C  449  GLU GLU VAL HIS VAL ARG GLY HIS ALA VAL GLU CYS ARG          
SEQRES  27 C  449  ILE ASN ALA GLU ASP PRO ASN THR PHE LEU PRO SER PRO          
SEQRES  28 C  449  GLY LYS ILE THR ARG PHE HIS ALA PRO GLY GLY PHE GLY          
SEQRES  29 C  449  VAL ARG TRP GLU SER HIS ILE TYR ALA GLY TYR THR VAL          
SEQRES  30 C  449  PRO PRO TYR TYR ASP SER MET ILE GLY LYS LEU ILE CYS          
SEQRES  31 C  449  TYR GLY GLU ASN ARG ASP VAL ALA ILE ALA ARG MET LYS          
SEQRES  32 C  449  ASN ALA LEU GLN GLU LEU ILE ILE ASP GLY ILE LYS THR          
SEQRES  33 C  449  ASN VAL ASP LEU GLN ILE ARG ILE MET ASN ASP GLU ASN          
SEQRES  34 C  449  PHE GLN HIS GLY GLY THR ASN ILE HIS TYR LEU GLU LYS          
SEQRES  35 C  449  LYS LEU GLY LEU GLN GLU LYS                                  
SEQRES   1 D  176  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 D  176  LEU VAL PRO ARG GLY SER HIS MET ASP ILE ARG LYS ILE          
SEQRES   3 D  176  LYS LYS LEU ILE GLU LEU VAL GLU GLU SER GLY ILE SER          
SEQRES   4 D  176  GLU LEU GLU ILE SER GLU GLY GLU GLU SER VAL ARG ILE          
SEQRES   5 D  176  SER ARG ALA ALA PRO ALA ALA SER PHE PRO VAL MET GLN          
SEQRES   6 D  176  GLN ALA TYR ALA ALA PRO MET MET GLN GLN PRO ALA GLN          
SEQRES   7 D  176  SER ASN ALA ALA ALA PRO ALA THR VAL PRO SER MET GLU          
SEQRES   8 D  176  ALA PRO ALA ALA ALA GLU ILE SER GLY HIS ILE VAL ARG          
SEQRES   9 D  176  SER PRO MET VAL GLY THR PHE TYR ARG THR PRO SER PRO          
SEQRES  10 D  176  ASP ALA LYS ALA PHE ILE GLU VAL GLY GLN LYS VAL ASN          
SEQRES  11 D  176  VAL GLY ASP THR LEU CYS ILE VAL GLU ALA MET LYS MET          
SEQRES  12 D  176  MET ASN GLN ILE GLU ALA ASP LYS SER GLY THR VAL LYS          
SEQRES  13 D  176  ALA ILE LEU VAL GLU SER GLY GLN PRO VAL GLU PHE ASP          
SEQRES  14 D  176  GLU PRO LEU VAL VAL ILE GLU                                  
SEQRES   1 E  449  MET LEU ASP LYS ILE VAL ILE ALA ASN ARG GLY GLU ILE          
SEQRES   2 E  449  ALA LEU ARG ILE LEU ARG ALA CYS LYS GLU LEU GLY ILE          
SEQRES   3 E  449  LYS THR VAL ALA VAL HIS SER SER ALA ASP ARG ASP LEU          
SEQRES   4 E  449  LYS HIS VAL LEU LEU ALA ASP GLU THR VAL CYS ILE GLY          
SEQRES   5 E  449  PRO ALA PRO SER VAL LYS SER TYR LEU ASN ILE PRO ALA          
SEQRES   6 E  449  ILE ILE SER ALA ALA GLU ILE THR GLY ALA VAL ALA ILE          
SEQRES   7 E  449  HIS PRO GLY TYR GLY PHE LEU SER GLU ASN ALA ASN PHE          
SEQRES   8 E  449  ALA GLU GLN VAL GLU ARG SER GLY PHE ILE PHE ILE GLY          
SEQRES   9 E  449  PRO LYS ALA GLU THR ILE ARG LEU MET GLY ASP LYS VAL          
SEQRES  10 E  449  SER ALA ILE ALA ALA MET LYS LYS ALA GLY VAL PRO CYS          
SEQRES  11 E  449  VAL PRO GLY SER ASP GLY PRO LEU GLY ASP ASP MET ASP          
SEQRES  12 E  449  LYS ASN ARG ALA ILE ALA LYS ARG ILE GLY TYR PRO VAL          
SEQRES  13 E  449  ILE ILE LYS ALA SER GLY GLY GLY GLY GLY ARG GLY MET          
SEQRES  14 E  449  ARG VAL VAL ARG GLY ASP ALA GLU LEU ALA GLN SER ILE          
SEQRES  15 E  449  SER MET THR ARG ALA GLU ALA LYS ALA ALA PHE SER ASN          
SEQRES  16 E  449  ASP MET VAL TYR MET GLU LYS TYR LEU GLU ASN PRO ARG          
SEQRES  17 E  449  HIS VAL GLU ILE GLN VAL LEU ALA ASP GLY GLN GLY ASN          
SEQRES  18 E  449  ALA ILE TYR LEU ALA GLU ARG ASP CYS SER MET GLN ARG          
SEQRES  19 E  449  ARG HIS GLN LYS VAL VAL GLU GLU ALA PRO ALA PRO GLY          
SEQRES  20 E  449  ILE THR PRO GLU LEU ARG ARG TYR ILE GLY GLU ARG CYS          
SEQRES  21 E  449  ALA LYS ALA CYS VAL ASP ILE GLY TYR ARG GLY ALA GLY          
SEQRES  22 E  449  THR PHE GLU PHE LEU PHE GLU ASN GLY GLU PHE TYR PHE          
SEQRES  23 E  449  ILE GLU MET ASN THR ARG ILE GLN VAL GLU HIS PRO VAL          
SEQRES  24 E  449  THR GLU MET ILE THR GLY VAL ASP LEU ILE LYS GLU GLN          
SEQRES  25 E  449  LEU ARG ILE ALA ALA GLY GLN PRO LEU SER ILE LYS GLN          
SEQRES  26 E  449  GLU GLU VAL HIS VAL ARG GLY HIS ALA VAL GLU CYS ARG          
SEQRES  27 E  449  ILE ASN ALA GLU ASP PRO ASN THR PHE LEU PRO SER PRO          
SEQRES  28 E  449  GLY LYS ILE THR ARG PHE HIS ALA PRO GLY GLY PHE GLY          
SEQRES  29 E  449  VAL ARG TRP GLU SER HIS ILE TYR ALA GLY TYR THR VAL          
SEQRES  30 E  449  PRO PRO TYR TYR ASP SER MET ILE GLY LYS LEU ILE CYS          
SEQRES  31 E  449  TYR GLY GLU ASN ARG ASP VAL ALA ILE ALA ARG MET LYS          
SEQRES  32 E  449  ASN ALA LEU GLN GLU LEU ILE ILE ASP GLY ILE LYS THR          
SEQRES  33 E  449  ASN VAL ASP LEU GLN ILE ARG ILE MET ASN ASP GLU ASN          
SEQRES  34 E  449  PHE GLN HIS GLY GLY THR ASN ILE HIS TYR LEU GLU LYS          
SEQRES  35 E  449  LYS LEU GLY LEU GLN GLU LYS                                  
SEQRES   1 F  449  MET LEU ASP LYS ILE VAL ILE ALA ASN ARG GLY GLU ILE          
SEQRES   2 F  449  ALA LEU ARG ILE LEU ARG ALA CYS LYS GLU LEU GLY ILE          
SEQRES   3 F  449  LYS THR VAL ALA VAL HIS SER SER ALA ASP ARG ASP LEU          
SEQRES   4 F  449  LYS HIS VAL LEU LEU ALA ASP GLU THR VAL CYS ILE GLY          
SEQRES   5 F  449  PRO ALA PRO SER VAL LYS SER TYR LEU ASN ILE PRO ALA          
SEQRES   6 F  449  ILE ILE SER ALA ALA GLU ILE THR GLY ALA VAL ALA ILE          
SEQRES   7 F  449  HIS PRO GLY TYR GLY PHE LEU SER GLU ASN ALA ASN PHE          
SEQRES   8 F  449  ALA GLU GLN VAL GLU ARG SER GLY PHE ILE PHE ILE GLY          
SEQRES   9 F  449  PRO LYS ALA GLU THR ILE ARG LEU MET GLY ASP LYS VAL          
SEQRES  10 F  449  SER ALA ILE ALA ALA MET LYS LYS ALA GLY VAL PRO CYS          
SEQRES  11 F  449  VAL PRO GLY SER ASP GLY PRO LEU GLY ASP ASP MET ASP          
SEQRES  12 F  449  LYS ASN ARG ALA ILE ALA LYS ARG ILE GLY TYR PRO VAL          
SEQRES  13 F  449  ILE ILE LYS ALA SER GLY GLY GLY GLY GLY ARG GLY MET          
SEQRES  14 F  449  ARG VAL VAL ARG GLY ASP ALA GLU LEU ALA GLN SER ILE          
SEQRES  15 F  449  SER MET THR ARG ALA GLU ALA LYS ALA ALA PHE SER ASN          
SEQRES  16 F  449  ASP MET VAL TYR MET GLU LYS TYR LEU GLU ASN PRO ARG          
SEQRES  17 F  449  HIS VAL GLU ILE GLN VAL LEU ALA ASP GLY GLN GLY ASN          
SEQRES  18 F  449  ALA ILE TYR LEU ALA GLU ARG ASP CYS SER MET GLN ARG          
SEQRES  19 F  449  ARG HIS GLN LYS VAL VAL GLU GLU ALA PRO ALA PRO GLY          
SEQRES  20 F  449  ILE THR PRO GLU LEU ARG ARG TYR ILE GLY GLU ARG CYS          
SEQRES  21 F  449  ALA LYS ALA CYS VAL ASP ILE GLY TYR ARG GLY ALA GLY          
SEQRES  22 F  449  THR PHE GLU PHE LEU PHE GLU ASN GLY GLU PHE TYR PHE          
SEQRES  23 F  449  ILE GLU MET ASN THR ARG ILE GLN VAL GLU HIS PRO VAL          
SEQRES  24 F  449  THR GLU MET ILE THR GLY VAL ASP LEU ILE LYS GLU GLN          
SEQRES  25 F  449  LEU ARG ILE ALA ALA GLY GLN PRO LEU SER ILE LYS GLN          
SEQRES  26 F  449  GLU GLU VAL HIS VAL ARG GLY HIS ALA VAL GLU CYS ARG          
SEQRES  27 F  449  ILE ASN ALA GLU ASP PRO ASN THR PHE LEU PRO SER PRO          
SEQRES  28 F  449  GLY LYS ILE THR ARG PHE HIS ALA PRO GLY GLY PHE GLY          
SEQRES  29 F  449  VAL ARG TRP GLU SER HIS ILE TYR ALA GLY TYR THR VAL          
SEQRES  30 F  449  PRO PRO TYR TYR ASP SER MET ILE GLY LYS LEU ILE CYS          
SEQRES  31 F  449  TYR GLY GLU ASN ARG ASP VAL ALA ILE ALA ARG MET LYS          
SEQRES  32 F  449  ASN ALA LEU GLN GLU LEU ILE ILE ASP GLY ILE LYS THR          
SEQRES  33 F  449  ASN VAL ASP LEU GLN ILE ARG ILE MET ASN ASP GLU ASN          
SEQRES  34 F  449  PHE GLN HIS GLY GLY THR ASN ILE HIS TYR LEU GLU LYS          
SEQRES  35 F  449  LYS LEU GLY LEU GLN GLU LYS                                  
SEQRES   1 G  176  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 G  176  LEU VAL PRO ARG GLY SER HIS MET ASP ILE ARG LYS ILE          
SEQRES   3 G  176  LYS LYS LEU ILE GLU LEU VAL GLU GLU SER GLY ILE SER          
SEQRES   4 G  176  GLU LEU GLU ILE SER GLU GLY GLU GLU SER VAL ARG ILE          
SEQRES   5 G  176  SER ARG ALA ALA PRO ALA ALA SER PHE PRO VAL MET GLN          
SEQRES   6 G  176  GLN ALA TYR ALA ALA PRO MET MET GLN GLN PRO ALA GLN          
SEQRES   7 G  176  SER ASN ALA ALA ALA PRO ALA THR VAL PRO SER MET GLU          
SEQRES   8 G  176  ALA PRO ALA ALA ALA GLU ILE SER GLY HIS ILE VAL ARG          
SEQRES   9 G  176  SER PRO MET VAL GLY THR PHE TYR ARG THR PRO SER PRO          
SEQRES  10 G  176  ASP ALA LYS ALA PHE ILE GLU VAL GLY GLN LYS VAL ASN          
SEQRES  11 G  176  VAL GLY ASP THR LEU CYS ILE VAL GLU ALA MET LYS MET          
SEQRES  12 G  176  MET ASN GLN ILE GLU ALA ASP LYS SER GLY THR VAL LYS          
SEQRES  13 G  176  ALA ILE LEU VAL GLU SER GLY GLN PRO VAL GLU PHE ASP          
SEQRES  14 G  176  GLU PRO LEU VAL VAL ILE GLU                                  
SEQRES   1 I  176  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 I  176  LEU VAL PRO ARG GLY SER HIS MET ASP ILE ARG LYS ILE          
SEQRES   3 I  176  LYS LYS LEU ILE GLU LEU VAL GLU GLU SER GLY ILE SER          
SEQRES   4 I  176  GLU LEU GLU ILE SER GLU GLY GLU GLU SER VAL ARG ILE          
SEQRES   5 I  176  SER ARG ALA ALA PRO ALA ALA SER PHE PRO VAL MET GLN          
SEQRES   6 I  176  GLN ALA TYR ALA ALA PRO MET MET GLN GLN PRO ALA GLN          
SEQRES   7 I  176  SER ASN ALA ALA ALA PRO ALA THR VAL PRO SER MET GLU          
SEQRES   8 I  176  ALA PRO ALA ALA ALA GLU ILE SER GLY HIS ILE VAL ARG          
SEQRES   9 I  176  SER PRO MET VAL GLY THR PHE TYR ARG THR PRO SER PRO          
SEQRES  10 I  176  ASP ALA LYS ALA PHE ILE GLU VAL GLY GLN LYS VAL ASN          
SEQRES  11 I  176  VAL GLY ASP THR LEU CYS ILE VAL GLU ALA MET LYS MET          
SEQRES  12 I  176  MET ASN GLN ILE GLU ALA ASP LYS SER GLY THR VAL LYS          
SEQRES  13 I  176  ALA ILE LEU VAL GLU SER GLY GLN PRO VAL GLU PHE ASP          
SEQRES  14 I  176  GLU PRO LEU VAL VAL ILE GLU                                  
HET    SO4  A 501       5                                                       
HET    SO4  A 502       5                                                       
HET    SO4  A 503       5                                                       
HET    SO4  A 504       5                                                       
HET    SO4  A 505       5                                                       
HET    SO4  C 501       5                                                       
HET    SO4  C 502       5                                                       
HET    EDO  C 503       4                                                       
HET    SO4  E 501       5                                                       
HET    SO4  E 502       5                                                       
HET    SO4  E 503       5                                                       
HET    SO4  F 501       5                                                       
HET    SO4  F 502       5                                                       
HETNAM     SO4 SULFATE ION                                                      
HETNAM     EDO 1,2-ETHANEDIOL                                                   
HETSYN     EDO ETHYLENE GLYCOL                                                  
FORMUL   9  SO4    12(O4 S 2-)                                                  
FORMUL  16  EDO    C2 H6 O2                                                     
FORMUL  22  HOH   *455(H2 O)                                                    
HELIX    1   1 ARG A   10  GLY A   25  1                                  16    
HELIX    2   2 ALA A   35  ARG A   37  5                                   3    
HELIX    3   3 LEU A   39  ALA A   45  1                                   7    
HELIX    4   4 PRO A   55  SER A   59  5                                   5    
HELIX    5   5 ASN A   62  GLY A   74  1                                  13    
HELIX    6   6 ASN A   88  SER A   98  1                                  11    
HELIX    7   7 LYS A  106  ASP A  115  1                                  10    
HELIX    8   8 ASP A  115  GLY A  127  1                                  13    
HELIX    9   9 ASP A  141  GLY A  153  1                                  13    
HELIX   10  10 GLY A  174  ALA A  176  5                                   3    
HELIX   11  11 GLU A  177  PHE A  193  1                                  17    
HELIX   12  12 THR A  249  GLY A  268  1                                  20    
HELIX   13  13 GLU A  296  GLY A  305  1                                  10    
HELIX   14  14 ASP A  307  ALA A  317  1                                  11    
HELIX   15  15 LYS A  324  VAL A  328  5                                   5    
HELIX   16  16 ASN A  394  LEU A  409  1                                  16    
HELIX   17  17 ASN A  417  ASP A  427  1                                  11    
HELIX   18  18 ASP A  427  GLY A  433  1                                   7    
HELIX   19  19 HIS A  438  LEU A  444  1                                   7    
HELIX   20  20 ARG C   10  LEU C   24  1                                  15    
HELIX   21  21 ALA C   35  ARG C   37  5                                   3    
HELIX   22  22 LEU C   39  ALA C   45  1                                   7    
HELIX   23  23 PRO C   55  SER C   59  5                                   5    
HELIX   24  24 ASN C   62  GLY C   74  1                                  13    
HELIX   25  25 ASN C   88  SER C   98  1                                  11    
HELIX   26  26 LYS C  106  ASP C  115  1                                  10    
HELIX   27  27 ASP C  115  GLY C  127  1                                  13    
HELIX   28  28 ASP C  141  GLY C  153  1                                  13    
HELIX   29  29 GLY C  174  ALA C  176  5                                   3    
HELIX   30  30 GLU C  177  ILE C  182  1                                   6    
HELIX   31  31 THR C  249  GLY C  268  1                                  20    
HELIX   32  32 GLU C  296  GLY C  305  1                                  10    
HELIX   33  33 ASP C  307  ALA C  317  1                                  11    
HELIX   34  34 LYS C  324  VAL C  328  5                                   5    
HELIX   35  35 ASN C  394  LEU C  409  1                                  16    
HELIX   36  36 ASN C  417  ASP C  427  1                                  11    
HELIX   37  37 ASP C  427  GLY C  433  1                                   7    
HELIX   38  38 HIS C  438  LEU C  444  1                                   7    
HELIX   39  39 ARG E   10  GLY E   25  1                                  16    
HELIX   40  40 LEU E   39  ALA E   45  1                                   7    
HELIX   41  41 PRO E   55  SER E   59  5                                   5    
HELIX   42  42 ASN E   62  GLY E   74  1                                  13    
HELIX   43  43 ASN E   88  SER E   98  1                                  11    
HELIX   44  44 LYS E  106  ASP E  115  1                                  10    
HELIX   45  45 ASP E  115  GLY E  127  1                                  13    
HELIX   46  46 ASP E  141  GLY E  153  1                                  13    
HELIX   47  47 GLY E  174  ALA E  176  5                                   3    
HELIX   48  48 GLU E  177  SER E  183  1                                   7    
HELIX   49  49 THR E  249  GLY E  268  1                                  20    
HELIX   50  50 GLU E  296  GLY E  305  1                                  10    
HELIX   51  51 ASP E  307  ALA E  317  1                                  11    
HELIX   52  52 LYS E  324  VAL E  328  5                                   5    
HELIX   53  53 ASN E  394  LEU E  409  1                                  16    
HELIX   54  54 ASN E  417  ASP E  427  1                                  11    
HELIX   55  55 ASP E  427  GLY E  433  1                                   7    
HELIX   56  56 HIS E  438  LEU E  444  1                                   7    
HELIX   57  57 ARG F   10  LEU F   24  1                                  15    
HELIX   58  58 ALA F   35  ARG F   37  5                                   3    
HELIX   59  59 LEU F   39  ALA F   45  1                                   7    
HELIX   60  60 PRO F   55  SER F   59  5                                   5    
HELIX   61  61 ASN F   62  GLY F   74  1                                  13    
HELIX   62  62 ASN F   88  SER F   98  1                                  11    
HELIX   63  63 LYS F  106  ASP F  115  1                                  10    
HELIX   64  64 ASP F  115  GLY F  127  1                                  13    
HELIX   65  65 ASP F  141  GLY F  153  1                                  13    
HELIX   66  66 GLY F  174  ALA F  176  5                                   3    
HELIX   67  67 GLU F  177  MET F  184  1                                   8    
HELIX   68  68 THR F  249  GLY F  268  1                                  20    
HELIX   69  69 GLU F  296  GLY F  305  1                                  10    
HELIX   70  70 ASP F  307  ALA F  317  1                                  11    
HELIX   71  71 LYS F  324  VAL F  328  5                                   5    
HELIX   72  72 ASN F  394  LEU F  409  1                                  16    
HELIX   73  73 ASN F  417  ASP F  427  1                                  11    
HELIX   74  74 ASP F  427  GLY F  433  1                                   7    
HELIX   75  75 HIS F  438  LEU F  444  1                                   7    
SHEET    1   A 5 GLU A  47  GLY A  52  0                                        
SHEET    2   A 5 LYS A  27  SER A  33  1  N  ALA A  30   O  GLU A  47           
SHEET    3   A 5 LYS A   4  ILE A   7  1  N  ILE A   5   O  LYS A  27           
SHEET    4   A 5 ALA A  77  HIS A  79  1  O  HIS A  79   N  VAL A   6           
SHEET    5   A 5 ILE A 101  PHE A 102  1  O  ILE A 101   N  ILE A  78           
SHEET    1   B 3 ARG A 170  VAL A 172  0                                        
SHEET    2   B 3 VAL A 156  ALA A 160 -1  N  VAL A 156   O  VAL A 172           
SHEET    3   B 3 VAL A 198  LYS A 202 -1  O  GLU A 201   N  ILE A 157           
SHEET    1   C 4 ALA A 222  ASP A 229  0                                        
SHEET    2   C 4 ARG A 208  ASP A 217 -1  N  GLN A 213   O  LEU A 225           
SHEET    3   C 4 ARG A 270  GLU A 280 -1  O  GLY A 271   N  ALA A 216           
SHEET    4   C 4 GLU A 283  ASN A 290 -1  O  ILE A 287   N  GLU A 276           
SHEET    1   D 2 GLN A 233  ARG A 234  0                                        
SHEET    2   D 2 GLN A 237  LYS A 238 -1  O  GLN A 237   N  ARG A 234           
SHEET    1   E 4 VAL A 240  ALA A 243  0                                        
SHEET    2   E 4 HIS A 333  ASN A 340 -1  O  GLU A 336   N  GLU A 241           
SHEET    3   E 4 MET A 384  GLY A 392 -1  O  ILE A 385   N  ILE A 339           
SHEET    4   E 4 VAL A 365  SER A 369 -1  N  GLU A 368   O  LYS A 387           
SHEET    1   F 2 GLY A 352  LYS A 353  0                                        
SHEET    2   F 2 THR A 376  VAL A 377 -1  O  VAL A 377   N  GLY A 352           
SHEET    1   G 2 ARG A 356  HIS A 358  0                                        
SHEET    2   G 2 ILE A 410  ASP A 412 -1  O  ASP A 412   N  ARG A 356           
SHEET    1   H 4 HIS B  81  ARG B  84  0                                        
SHEET    2   H 4 PRO B 151  ILE B 155 -1  O  LEU B 152   N  VAL B  83           
SHEET    3   H 4 GLY B 133  ILE B 138 -1  N  ALA B 137   O  VAL B 154           
SHEET    4   H 4 LYS B 108  VAL B 109 -1  N  VAL B 109   O  GLY B 133           
SHEET    1   I 4 MET B 123  GLU B 128  0                                        
SHEET    2   I 4 THR B 114  ALA B 120 -1  N  VAL B 118   O  ASN B 125           
SHEET    3   I 4 GLY B  89  TYR B  92 -1  N  THR B  90   O  GLU B 119           
SHEET    4   I 4 PRO B 145  VAL B 146 -1  O  VAL B 146   N  GLY B  89           
SHEET    1   J 5 GLU C  47  GLY C  52  0                                        
SHEET    2   J 5 LYS C  27  SER C  33  1  N  ALA C  30   O  GLU C  47           
SHEET    3   J 5 LYS C   4  ILE C   7  1  N  ILE C   7   O  VAL C  29           
SHEET    4   J 5 ALA C  77  HIS C  79  1  O  HIS C  79   N  VAL C   6           
SHEET    5   J 5 ILE C 101  PHE C 102  1  O  ILE C 101   N  ILE C  78           
SHEET    1   K 3 VAL C 171  VAL C 172  0                                        
SHEET    2   K 3 VAL C 156  ALA C 160 -1  N  VAL C 156   O  VAL C 172           
SHEET    3   K 3 VAL C 198  LYS C 202 -1  O  GLU C 201   N  ILE C 157           
SHEET    1   L 4 ALA C 222  ASP C 229  0                                        
SHEET    2   L 4 ARG C 208  ASP C 217 -1  N  GLN C 213   O  LEU C 225           
SHEET    3   L 4 ARG C 270  GLU C 280 -1  O  GLY C 271   N  ALA C 216           
SHEET    4   L 4 GLU C 283  ASN C 290 -1  O  GLU C 288   N  GLU C 276           
SHEET    1   M 2 GLN C 233  ARG C 234  0                                        
SHEET    2   M 2 GLN C 237  LYS C 238 -1  O  GLN C 237   N  ARG C 234           
SHEET    1   N 4 VAL C 240  ALA C 243  0                                        
SHEET    2   N 4 HIS C 333  ASN C 340 -1  O  GLU C 336   N  GLU C 241           
SHEET    3   N 4 MET C 384  GLY C 392 -1  O  ILE C 385   N  ILE C 339           
SHEET    4   N 4 VAL C 365  SER C 369 -1  N  GLU C 368   O  LYS C 387           
SHEET    1   O 2 GLY C 352  LYS C 353  0                                        
SHEET    2   O 2 THR C 376  VAL C 377 -1  O  VAL C 377   N  GLY C 352           
SHEET    1   P 2 ARG C 356  HIS C 358  0                                        
SHEET    2   P 2 ILE C 410  ASP C 412 -1  O  ASP C 412   N  ARG C 356           
SHEET    1   Q 4 HIS D  81  ARG D  84  0                                        
SHEET    2   Q 4 PRO D 151  ILE D 155 -1  O  VAL D 153   N  VAL D  83           
SHEET    3   Q 4 GLY D 133  ILE D 138 -1  N  LYS D 136   O  VAL D 154           
SHEET    4   Q 4 LYS D 108  VAL D 109 -1  N  VAL D 109   O  GLY D 133           
SHEET    1   R 4 MET D 123  GLU D 128  0                                        
SHEET    2   R 4 THR D 114  ALA D 120 -1  N  VAL D 118   O  ASN D 125           
SHEET    3   R 4 GLY D  89  TYR D  92 -1  N  THR D  90   O  GLU D 119           
SHEET    4   R 4 PRO D 145  VAL D 146 -1  O  VAL D 146   N  GLY D  89           
SHEET    1   S 5 GLU E  47  GLY E  52  0                                        
SHEET    2   S 5 LYS E  27  SER E  33  1  N  ALA E  30   O  GLU E  47           
SHEET    3   S 5 LYS E   4  ILE E   7  1  N  ILE E   7   O  VAL E  29           
SHEET    4   S 5 ALA E  77  HIS E  79  1  O  HIS E  79   N  VAL E   6           
SHEET    5   S 5 ILE E 101  PHE E 102  1  O  ILE E 101   N  ILE E  78           
SHEET    1   T 3 VAL E 171  VAL E 172  0                                        
SHEET    2   T 3 VAL E 156  ILE E 158 -1  N  VAL E 156   O  VAL E 172           
SHEET    3   T 3 MET E 200  LYS E 202 -1  O  GLU E 201   N  ILE E 157           
SHEET    1   U 4 ALA E 222  ASP E 229  0                                        
SHEET    2   U 4 ARG E 208  ASP E 217 -1  N  GLN E 213   O  LEU E 225           
SHEET    3   U 4 ARG E 270  GLU E 280 -1  O  GLY E 271   N  ALA E 216           
SHEET    4   U 4 GLU E 283  ASN E 290 -1  O  TYR E 285   N  LEU E 278           
SHEET    1   V 2 GLN E 233  ARG E 234  0                                        
SHEET    2   V 2 GLN E 237  LYS E 238 -1  O  GLN E 237   N  ARG E 234           
SHEET    1   W 4 VAL E 240  ALA E 243  0                                        
SHEET    2   W 4 HIS E 333  ASN E 340 -1  O  GLU E 336   N  GLU E 241           
SHEET    3   W 4 MET E 384  GLY E 392 -1  O  ILE E 385   N  ILE E 339           
SHEET    4   W 4 VAL E 365  SER E 369 -1  N  GLU E 368   O  LYS E 387           
SHEET    1   X 2 GLY E 352  LYS E 353  0                                        
SHEET    2   X 2 THR E 376  VAL E 377 -1  O  VAL E 377   N  GLY E 352           
SHEET    1   Y 2 ARG E 356  HIS E 358  0                                        
SHEET    2   Y 2 ILE E 410  ASP E 412 -1  O  ILE E 410   N  HIS E 358           
SHEET    1   Z 5 GLU F  47  GLY F  52  0                                        
SHEET    2   Z 5 LYS F  27  SER F  33  1  N  ALA F  30   O  GLU F  47           
SHEET    3   Z 5 LYS F   4  ILE F   7  1  N  ILE F   5   O  LYS F  27           
SHEET    4   Z 5 ALA F  77  HIS F  79  1  O  HIS F  79   N  VAL F   6           
SHEET    5   Z 5 ILE F 101  PHE F 102  1  O  ILE F 101   N  ILE F  78           
SHEET    1  AA 3 ARG F 170  VAL F 172  0                                        
SHEET    2  AA 3 VAL F 156  LYS F 159 -1  N  VAL F 156   O  VAL F 172           
SHEET    3  AA 3 TYR F 199  LYS F 202 -1  O  GLU F 201   N  ILE F 157           
SHEET    1  AB 4 ALA F 222  ASP F 229  0                                        
SHEET    2  AB 4 ARG F 208  ASP F 217 -1  N  GLU F 211   O  ARG F 228           
SHEET    3  AB 4 ARG F 270  GLU F 280 -1  O  GLY F 271   N  ALA F 216           
SHEET    4  AB 4 GLU F 283  ASN F 290 -1  O  GLU F 288   N  GLU F 276           
SHEET    1  AC 2 GLN F 233  ARG F 234  0                                        
SHEET    2  AC 2 GLN F 237  LYS F 238 -1  O  GLN F 237   N  ARG F 234           
SHEET    1  AD 4 VAL F 240  ALA F 243  0                                        
SHEET    2  AD 4 HIS F 333  ASN F 340 -1  O  GLU F 336   N  GLU F 241           
SHEET    3  AD 4 MET F 384  GLY F 392 -1  O  ILE F 385   N  ILE F 339           
SHEET    4  AD 4 VAL F 365  SER F 369 -1  N  GLU F 368   O  LYS F 387           
SHEET    1  AE 2 GLY F 352  LYS F 353  0                                        
SHEET    2  AE 2 THR F 376  VAL F 377 -1  O  VAL F 377   N  GLY F 352           
SHEET    1  AF 2 ARG F 356  HIS F 358  0                                        
SHEET    2  AF 2 ILE F 410  ASP F 412 -1  O  ASP F 412   N  ARG F 356           
SHEET    1  AG 4 HIS G  81  ARG G  84  0                                        
SHEET    2  AG 4 PRO G 151  ILE G 155 -1  O  LEU G 152   N  VAL G  83           
SHEET    3  AG 4 GLY G 133  ILE G 138 -1  N  LYS G 136   O  VAL G 154           
SHEET    4  AG 4 LYS G 108  VAL G 109 -1  N  VAL G 109   O  GLY G 133           
SHEET    1  AH 4 MET G 123  GLU G 128  0                                        
SHEET    2  AH 4 THR G 114  ALA G 120 -1  N  LEU G 115   O  ILE G 127           
SHEET    3  AH 4 GLY G  89  TYR G  92 -1  N  THR G  90   O  GLU G 119           
SHEET    4  AH 4 PRO G 145  VAL G 146 -1  O  VAL G 146   N  GLY G  89           
SHEET    1  AI 4 HIS I  81  ARG I  84  0                                        
SHEET    2  AI 4 PRO I 151  GLU I 156 -1  O  VAL I 153   N  VAL I  83           
SHEET    3  AI 4 GLY I 133  ILE I 138 -1  N  THR I 134   O  GLU I 156           
SHEET    4  AI 4 LYS I 108  VAL I 109 -1  N  VAL I 109   O  GLY I 133           
SHEET    1  AJ 4 MET I 123  GLU I 128  0                                        
SHEET    2  AJ 4 THR I 114  ALA I 120 -1  N  VAL I 118   O  ASN I 125           
SHEET    3  AJ 4 GLY I  89  TYR I  92 -1  N  THR I  90   O  GLU I 119           
SHEET    4  AJ 4 PRO I 145  VAL I 146 -1  O  VAL I 146   N  GLY I  89           
CISPEP   1 TYR A  154    PRO A  155          0        -0.36                     
CISPEP   2 ALA A  243    PRO A  244          0        -2.72                     
CISPEP   3 TYR C  154    PRO C  155          0        -0.44                     
CISPEP   4 ALA C  243    PRO C  244          0        -2.80                     
CISPEP   5 TYR E  154    PRO E  155          0        -1.62                     
CISPEP   6 ALA E  243    PRO E  244          0        -2.82                     
CISPEP   7 TYR F  154    PRO F  155          0         0.46                     
CISPEP   8 ALA F  243    PRO F  244          0        -3.20                     
SITE     1 AC1  5 SER A  56  TYR A 380  TYR A 381  HOH A 660                    
SITE     2 AC1  5 ARG B  84                                                     
SITE     1 AC2  7 LYS A 238  ARG A 292  GLN A 294  VAL A 295                    
SITE     2 AC2  7 GLU A 296  ARG A 338  HOH A 636                               
SITE     1 AC3  4 PRO A 250  ARG A 253  VAL A 330  HOH A 666                    
SITE     1 AC4  8 SER A  34  ALA A  35  HOH A 669  HOH A 672                    
SITE     2 AC4  8 HOH A 704  SER E  34  ALA E  35  ALA E  54                    
SITE     1 AC5  6 ARG A  10  HIS A 370  TYR A 375  VAL A 377                    
SITE     2 AC5  6 PRO A 378  ILE A 385                                          
SITE     1 AC6  6 SER C  56  TYR C 380  TYR C 381  HOH C 647                    
SITE     2 AC6  6 ILE D  82  ARG D  84                                          
SITE     1 AC7  6 LYS C 238  ARG C 292  GLN C 294  VAL C 295                    
SITE     2 AC7  6 GLU C 296  ARG C 338                                          
SITE     1 AC8  7 ASP C 229  CYS C 230  SER C 231  MET C 232                    
SITE     2 AC8  7 VAL C 240  GLU C 242  THR C 435                               
SITE     1 AC9  4 SER E  56  TYR E 380  TYR E 381  ARG I  84                    
SITE     1 BC1  7 LYS E 238  ARG E 292  GLN E 294  VAL E 295                    
SITE     2 BC1  7 GLU E 296  ARG E 338  HOH E 714                               
SITE     1 BC2  6 ARG E  10  HIS E 370  TYR E 375  VAL E 377                    
SITE     2 BC2  6 PRO E 378  ILE E 385                                          
SITE     1 BC3  6 PRO F  55  SER F  56  TYR F 381  HOH F 671                    
SITE     2 BC3  6 ILE G  82  ARG G  84                                          
SITE     1 BC4  6 LYS F 238  ARG F 292  GLN F 294  VAL F 295                    
SITE     2 BC4  6 GLU F 296  ARG F 338                                          
CRYST1  232.995   96.385  120.573  90.00 120.15  90.00 C 1 2 1      16          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.004292  0.000000  0.002493        0.00000                         
SCALE2      0.000000  0.010375  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.009591        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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