GenomeNet

Database: PDB
Entry: 4JQ0
LinkDB: 4JQ0
Original site: 4JQ0 
HEADER    TRANSPORT PROTEIN                       19-MAR-13   4JQ0              
TITLE     VOLTAGE-GATED SODIUM CHANNEL 1.5 C-TERMINAL DOMAIN IN COMPLEX WITH    
TITLE    2 FGF12B AND CA2+/CALMODULIN                                           
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: FIBROBLAST GROWTH FACTOR 12;                               
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: FGF-12, FIBROBLAST GROWTH FACTOR HOMOLOGOUS FACTOR 1, FHF-1,
COMPND   5 MYOCYTE-ACTIVATING FACTOR;                                           
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: CALMODULIN;                                                
COMPND   9 CHAIN: C;                                                            
COMPND  10 SYNONYM: CAM;                                                        
COMPND  11 ENGINEERED: YES;                                                     
COMPND  12 MOL_ID: 3;                                                           
COMPND  13 MOLECULE: SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA;               
COMPND  14 CHAIN: D;                                                            
COMPND  15 SYNONYM: HH1, SODIUM CHANNEL PROTEIN CARDIAC MUSCLE SUBUNIT ALPHA,   
COMPND  16 SODIUM CHANNEL PROTEIN TYPE V SUBUNIT ALPHA, VOLTAGE-GATED SODIUM    
COMPND  17 CHANNEL SUBUNIT ALPHA NAV1.5;                                        
COMPND  18 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: FGF12, FGF12B, FHF1;                                           
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: CALM1, CALM, CAM, CAM1, CALM2, CAM2, CAMB, CALM3, CALML2,      
SOURCE  13 CAM3, CAMC, CAMIII;                                                  
SOURCE  14 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  15 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  16 MOL_ID: 3;                                                           
SOURCE  17 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  18 ORGANISM_COMMON: HUMAN;                                              
SOURCE  19 ORGANISM_TAXID: 9606;                                                
SOURCE  20 GENE: SCN5A;                                                         
SOURCE  21 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  22 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    EF HAND, ION CHANNEL, MEMBRANE, TRANSPORT PROTEIN                     
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    C.WANG,B.C.CHUNG,H.YAN,H.G.WANG,S.Y.LEE,G.S.PITT                      
REVDAT   4   28-FEB-24 4JQ0    1       REMARK SEQADV LINK                       
REVDAT   3   03-DEC-14 4JQ0    1       AUTHOR                                   
REVDAT   2   22-OCT-14 4JQ0    1       JRNL                                     
REVDAT   1   21-MAY-14 4JQ0    0                                                
JRNL        AUTH   C.WANG,B.C.CHUNG,H.YAN,H.G.WANG,S.Y.LEE,G.S.PITT             
JRNL        TITL   STRUCTURAL ANALYSES OF CA(2+)/CAM INTERACTION WITH NAV       
JRNL        TITL 2 CHANNEL C-TERMINI REVEAL MECHANISMS OF CALCIUM-DEPENDENT     
JRNL        TITL 3 REGULATION.                                                  
JRNL        REF    NAT COMMUN                    V.   5  4896 2014              
JRNL        REFN                   ESSN 2041-1723                               
JRNL        PMID   25232683                                                     
JRNL        DOI    10.1038/NCOMMS5896                                           
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.84 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.8_1069)                     
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.84                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 41.57                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.380                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 40.5                           
REMARK   3   NUMBER OF REFLECTIONS             : 3700                           
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.257                           
REMARK   3   R VALUE            (WORKING SET) : 0.253                           
REMARK   3   FREE R VALUE                     : 0.320                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.460                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 202                             
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.610            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 35.400           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.010           3013                                  
REMARK   3   ANGLE     :  0.979           4114                                  
REMARK   3   CHIRALITY :  0.057            492                                  
REMARK   3   PLANARITY :  0.003            545                                  
REMARK   3   DIHEDRAL  : 11.328            988                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 15                                         
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 12 THROUGH 73 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -82.1254  49.3693 -49.3605              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9015 T22:   1.1422                                     
REMARK   3      T33:  -0.4898 T12:   0.8652                                     
REMARK   3      T13:  -0.7673 T23:   0.2737                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.7815 L22:   1.5602                                     
REMARK   3      L33:   0.9149 L12:  -0.1871                                     
REMARK   3      L13:   0.6324 L23:  -0.8560                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0119 S12:  -0.4698 S13:   0.1608                       
REMARK   3      S21:  -0.0864 S22:   1.1606 S23:   0.6474                       
REMARK   3      S31:   0.4262 S32:  -0.0411 S33:   1.8888                       
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 74 THROUGH 83 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -82.6658  54.2479 -36.9030              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.3124 T22:   1.0310                                     
REMARK   3      T33:   1.1368 T12:   0.7139                                     
REMARK   3      T13:  -0.4231 T23:   0.1896                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.6824 L22:   1.0672                                     
REMARK   3      L33:   2.7329 L12:   0.8806                                     
REMARK   3      L13:   1.9384 L23:   0.9181                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1853 S12:   0.5787 S13:   0.3978                       
REMARK   3      S21:  -0.3667 S22:  -0.0534 S23:   0.4630                       
REMARK   3      S31:  -0.2234 S32:   0.0039 S33:  -0.0638                       
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 84 THROUGH 152 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): -72.5814  46.1915 -42.5207              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8232 T22:   1.9116                                     
REMARK   3      T33:   0.2734 T12:   1.3429                                     
REMARK   3      T13:  -0.8057 T23:   0.1211                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.0504 L22:   1.0423                                     
REMARK   3      L33:   1.6072 L12:  -0.2746                                     
REMARK   3      L13:   0.6197 L23:  -1.1600                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.6592 S12:  -0.6211 S13:   0.5290                       
REMARK   3      S21:   0.6645 S22:   0.0874 S23:  -0.0938                       
REMARK   3      S31:   0.4603 S32:   0.3266 S33:  -0.8173                       
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 7 THROUGH 20 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): -69.2542  21.4254 -94.6687              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2693 T22:   2.2449                                     
REMARK   3      T33:   0.6307 T12:  -0.2767                                     
REMARK   3      T13:   0.8620 T23:  -0.3547                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.1292 L22:   0.4732                                     
REMARK   3      L33:   0.2038 L12:   0.0885                                     
REMARK   3      L13:  -0.3807 L23:  -0.0784                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1481 S12:  -0.6587 S13:   0.4063                       
REMARK   3      S21:   0.5836 S22:  -0.6104 S23:   0.4980                       
REMARK   3      S31:   0.5959 S32:  -0.3569 S33:  -0.5250                       
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 21 THROUGH 40 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -83.4934  22.6080 -89.4570              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2935 T22:   2.2940                                     
REMARK   3      T33:   1.8511 T12:  -0.3384                                     
REMARK   3      T13:   0.2836 T23:   0.2299                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.3651 L22:   1.5496                                     
REMARK   3      L33:   0.6699 L12:  -2.7225                                     
REMARK   3      L13:   1.7760 L23:  -0.9659                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3018 S12:  -0.8103 S13:  -0.5454                       
REMARK   3      S21:   0.3057 S22:   0.2552 S23:   0.4599                       
REMARK   3      S31:   0.9801 S32:  -0.2492 S33:  -0.1642                       
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 41 THROUGH 56 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -83.7736  31.2611 -81.0886              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.6495 T22:   1.9397                                     
REMARK   3      T33:   1.8447 T12:   0.2710                                     
REMARK   3      T13:  -0.0971 T23:   0.6407                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.6747 L22:   6.2537                                     
REMARK   3      L33:   4.7398 L12:  -5.7563                                     
REMARK   3      L13:   3.0111 L23:  -1.9710                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3166 S12:  -0.1782 S13:  -0.1474                       
REMARK   3      S21:   0.2058 S22:   0.1128 S23:   0.0742                       
REMARK   3      S31:  -0.4285 S32:  -0.1891 S33:  -0.1102                       
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 57 THROUGH 99 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -67.0094  30.9645 -80.5006              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3780 T22:   1.9256                                     
REMARK   3      T33:   0.7716 T12:  -0.3701                                     
REMARK   3      T13:   0.1461 T23:  -0.0470                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.0076 L22:   1.8316                                     
REMARK   3      L33:   0.6787 L12:  -0.0326                                     
REMARK   3      L13:   0.6670 L23:   0.5033                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3058 S12:  -0.5617 S13:   0.2293                       
REMARK   3      S21:  -0.8805 S22:   0.1482 S23:   0.4923                       
REMARK   3      S31:  -0.2813 S32:  -0.3906 S33:   0.1759                       
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 100 THROUGH 112 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): -66.7444  23.7008 -61.3248              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.7677 T22:   0.9542                                     
REMARK   3      T33:   1.4163 T12:   0.0318                                     
REMARK   3      T13:  -0.6829 T23:  -0.0270                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.8732 L22:   3.1550                                     
REMARK   3      L33:   4.5254 L12:   0.2349                                     
REMARK   3      L13:  -4.4013 L23:  -0.2278                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2994 S12:  -0.5096 S13:  -0.6292                       
REMARK   3      S21:   0.1193 S22:   0.3764 S23:   1.6229                       
REMARK   3      S31:  -0.3036 S32:  -1.7201 S33:  -0.1066                       
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 113 THROUGH 118 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): -73.0602  29.5012 -67.7038              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8573 T22:   1.5249                                     
REMARK   3      T33:   0.9056 T12:   0.2263                                     
REMARK   3      T13:   0.3285 T23:   0.2967                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.8533 L22:   6.1883                                     
REMARK   3      L33:   6.1785 L12:   5.0199                                     
REMARK   3      L13:   4.8007 L23:  -0.7344                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1220 S12:   0.7870 S13:  -1.1016                       
REMARK   3      S21:  -0.6944 S22:   0.1005 S23:   0.1156                       
REMARK   3      S31:   1.2786 S32:  -0.1751 S33:  -0.0722                       
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 119 THROUGH 148 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): -62.4517  17.5082 -68.7826              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9685 T22:   2.2590                                     
REMARK   3      T33:   1.5205 T12:   0.5163                                     
REMARK   3      T13:  -0.0608 T23:  -0.3452                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.6953 L22:   4.3430                                     
REMARK   3      L33:   5.7471 L12:   0.3834                                     
REMARK   3      L13:  -2.7933 L23:  -1.8599                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0849 S12:  -0.2300 S13:  -0.7240                       
REMARK   3      S21:  -0.3795 S22:   0.3878 S23:   0.2280                       
REMARK   3      S31:   0.5016 S32:   0.5864 S33:  -0.0492                       
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 1786 THROUGH 1807 )               
REMARK   3    ORIGIN FOR THE GROUP (A): -47.9341  58.3729 -59.3790              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6021 T22:   2.1490                                     
REMARK   3      T33:   1.7035 T12:  -0.2660                                     
REMARK   3      T13:  -0.5308 T23:   0.3401                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1307 L22:   0.0141                                     
REMARK   3      L33:   6.5614 L12:   0.0434                                     
REMARK   3      L13:   0.6490 L23:   0.2105                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2708 S12:   0.8743 S13:   0.6456                       
REMARK   3      S21:  -0.3487 S22:  -0.0829 S23:  -0.2730                       
REMARK   3      S31:  -0.7736 S32:   0.1787 S33:   0.3896                       
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 1808 THROUGH 1837 )               
REMARK   3    ORIGIN FOR THE GROUP (A): -51.1261  45.7228 -61.8851              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3056 T22:   1.8032                                     
REMARK   3      T33:   0.5885 T12:  -0.2069                                     
REMARK   3      T13:  -0.3139 T23:   0.2273                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.9650 L22:   2.5621                                     
REMARK   3      L33:   1.2033 L12:   0.3302                                     
REMARK   3      L13:   1.0749 L23:   0.2128                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3829 S12:   0.3038 S13:   0.7275                       
REMARK   3      S21:  -0.0894 S22:  -0.4936 S23:  -0.3204                       
REMARK   3      S31:  -0.1797 S32:  -0.0896 S33:  -0.7645                       
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 1838 THROUGH 1862 )               
REMARK   3    ORIGIN FOR THE GROUP (A): -57.8355  49.5958 -55.3423              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7464 T22:   1.7208                                     
REMARK   3      T33:   1.5191 T12:   0.7162                                     
REMARK   3      T13:  -0.7225 T23:  -0.1353                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3612 L22:   5.4989                                     
REMARK   3      L33:   2.0755 L12:   0.6362                                     
REMARK   3      L13:  -0.5457 L23:  -1.4027                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0264 S12:   0.6399 S13:  -0.2014                       
REMARK   3      S21:   0.0795 S22:   0.2256 S23:  -0.1388                       
REMARK   3      S31:   0.2100 S32:  -0.0445 S33:  -0.0059                       
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 1863 THROUGH 1895 )               
REMARK   3    ORIGIN FOR THE GROUP (A): -57.9906  57.0410 -48.4484              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.9181 T22:   1.8697                                     
REMARK   3      T33:   1.1848 T12:   0.4130                                     
REMARK   3      T13:   0.0061 T23:   0.0569                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.8469 L22:   0.2997                                     
REMARK   3      L33:   0.3403 L12:   0.5204                                     
REMARK   3      L13:   0.4381 L23:   0.3246                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5224 S12:  -0.6355 S13:   1.1584                       
REMARK   3      S21:   1.0686 S22:   0.0798 S23:   0.1450                       
REMARK   3      S31:  -1.3251 S32:   0.2896 S33:  -0.0307                       
REMARK   3   TLS GROUP : 15                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 1896 THROUGH 1927 )               
REMARK   3    ORIGIN FOR THE GROUP (A): -66.7287  27.1125 -75.8013              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0212 T22:   0.5125                                     
REMARK   3      T33:   1.5984 T12:  -0.2552                                     
REMARK   3      T13:   0.1643 T23:  -0.3587                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0327 L22:   0.2046                                     
REMARK   3      L33:   0.1292 L12:  -0.0746                                     
REMARK   3      L13:  -0.0204 L23:   0.0210                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0963 S12:   0.3215 S13:  -0.7308                       
REMARK   3      S21:  -0.8567 S22:   0.1725 S23:   0.4267                       
REMARK   3      S31:   0.3382 S32:   0.0743 S33:  -0.1296                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: THE DIFFRACTION DATA IS HEAVILY           
REMARK   3  ANISOTROPIC (3.8/5.4/6.0 A). AFTER ANISOTROPIC SCALING, THE         
REMARK   3  MODEL REFINES MUCH BETTER WITH INCLUSION OF HIGH-RESOLUTION         
REMARK   3  REFLECTIONS RATHER THAN CUTTING THE DATA TO THE LOW RESOLUTION.     
REMARK   3  (6.0 A). ANISOTROPY ALSO GIVES RISE TO THE LOW DATA COMPLETENESS.   
REMARK   4                                                                      
REMARK   4 4JQ0 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 27-MAR-13.                  
REMARK 100 THE DEPOSITION ID IS D_1000078358.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 11-AUG-12                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 7.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 22-ID                              
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.00                               
REMARK 200  MONOCHROMATOR                  : DOUBLE CRYSTAL - LIQUID NITROGEN   
REMARK 200                                   COOLED                             
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : MARMOSAIC 300 MM CCD               
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000                           
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 3705                               
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.830                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 46.068                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000                             
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 40.6                               
REMARK 200  DATA REDUNDANCY                : NULL                               
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : NULL                               
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.80                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.87                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 13.2                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHENIX (AUTOMR: 1.8_1069)                             
REMARK 200 STARTING MODEL: NULL                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 64.65                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.48                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 20% PEG3350, 0.18 M MGSO4, 0.1 M         
REMARK 280  SODIUM IODIDE, AND CACL2, PH 7.5, EVAPORATION, TEMPERATURE 290K     
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 31 2 1                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -Y,X-Y,Z+1/3                                            
REMARK 290       3555   -X+Y,-X,Z+2/3                                           
REMARK 290       4555   Y,X,-Z                                                  
REMARK 290       5555   X-Y,-Y,-Z+2/3                                           
REMARK 290       6555   -X,-X+Y,-Z+1/3                                          
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       40.03667            
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       80.07333            
REMARK 290   SMTRY1   4 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   4  0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   5  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   5  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000       80.07333            
REMARK 290   SMTRY1   6 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   6 -0.866025  0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000       40.03667            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC                          
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC                   
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 3610 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 21570 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -73.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, D                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A   -56                                                      
REMARK 465     ALA A   -55                                                      
REMARK 465     ALA A   -54                                                      
REMARK 465     ALA A   -53                                                      
REMARK 465     ILE A   -52                                                      
REMARK 465     ALA A   -51                                                      
REMARK 465     SER A   -50                                                      
REMARK 465     SER A   -49                                                      
REMARK 465     LEU A   -48                                                      
REMARK 465     ILE A   -47                                                      
REMARK 465     ARG A   -46                                                      
REMARK 465     GLN A   -45                                                      
REMARK 465     LYS A   -44                                                      
REMARK 465     ARG A   -43                                                      
REMARK 465     GLN A   -42                                                      
REMARK 465     ALA A   -41                                                      
REMARK 465     ARG A   -40                                                      
REMARK 465     GLU A   -39                                                      
REMARK 465     SER A   -38                                                      
REMARK 465     ASN A   -37                                                      
REMARK 465     SER A   -36                                                      
REMARK 465     ASP A   -35                                                      
REMARK 465     ARG A   -34                                                      
REMARK 465     VAL A   -33                                                      
REMARK 465     SER A   -32                                                      
REMARK 465     ALA A   -31                                                      
REMARK 465     SER A   -30                                                      
REMARK 465     LYS A   -29                                                      
REMARK 465     ARG A   -28                                                      
REMARK 465     ARG A   -27                                                      
REMARK 465     SER A   -26                                                      
REMARK 465     SER A   -25                                                      
REMARK 465     PRO A   -24                                                      
REMARK 465     SER A   -23                                                      
REMARK 465     LYS A   -22                                                      
REMARK 465     ASP A   -21                                                      
REMARK 465     GLY A   -20                                                      
REMARK 465     ARG A   -19                                                      
REMARK 465     SER A   -18                                                      
REMARK 465     LEU A   -17                                                      
REMARK 465     CYS A   -16                                                      
REMARK 465     GLU A   -15                                                      
REMARK 465     ARG A   -14                                                      
REMARK 465     HIS A   -13                                                      
REMARK 465     VAL A   -12                                                      
REMARK 465     LEU A   -11                                                      
REMARK 465     GLY A   -10                                                      
REMARK 465     VAL A    -9                                                      
REMARK 465     PHE A    -8                                                      
REMARK 465     SER A    -7                                                      
REMARK 465     LYS A    -6                                                      
REMARK 465     VAL A    -5                                                      
REMARK 465     ARG A    -4                                                      
REMARK 465     PHE A    -3                                                      
REMARK 465     CYS A    -2                                                      
REMARK 465     SER A    -1                                                      
REMARK 465     GLY A     0                                                      
REMARK 465     ARG A     1                                                      
REMARK 465     LYS A     2                                                      
REMARK 465     ARG A     3                                                      
REMARK 465     PRO A     4                                                      
REMARK 465     VAL A     5                                                      
REMARK 465     ARG A     6                                                      
REMARK 465     ARG A     7                                                      
REMARK 465     ARG A     8                                                      
REMARK 465     PRO A     9                                                      
REMARK 465     GLU A    10                                                      
REMARK 465     PRO A    11                                                      
REMARK 465     GLU A   153                                                      
REMARK 465     PRO A   154                                                      
REMARK 465     SER A   155                                                      
REMARK 465     LEU A   156                                                      
REMARK 465     HIS A   157                                                      
REMARK 465     GLU A   158                                                      
REMARK 465     ILE A   159                                                      
REMARK 465     GLY A   160                                                      
REMARK 465     GLU A   161                                                      
REMARK 465     LYS A   162                                                      
REMARK 465     GLN A   163                                                      
REMARK 465     GLY A   164                                                      
REMARK 465     ARG A   165                                                      
REMARK 465     SER A   166                                                      
REMARK 465     ARG A   167                                                      
REMARK 465     LYS A   168                                                      
REMARK 465     SER A   169                                                      
REMARK 465     SER A   170                                                      
REMARK 465     GLY A   171                                                      
REMARK 465     THR A   172                                                      
REMARK 465     PRO A   173                                                      
REMARK 465     THR A   174                                                      
REMARK 465     MET A   175                                                      
REMARK 465     ASN A   176                                                      
REMARK 465     GLY A   177                                                      
REMARK 465     GLY A   178                                                      
REMARK 465     LYS A   179                                                      
REMARK 465     VAL A   180                                                      
REMARK 465     VAL A   181                                                      
REMARK 465     ASN A   182                                                      
REMARK 465     GLN A   183                                                      
REMARK 465     ASP A   184                                                      
REMARK 465     SER A   185                                                      
REMARK 465     THR A   186                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ALA C     2                                                      
REMARK 465     ASP C     3                                                      
REMARK 465     GLN C     4                                                      
REMARK 465     LEU C     5                                                      
REMARK 465     THR C     6                                                      
REMARK 465     LYS C   149                                                      
REMARK 465     MET D  1750                                                      
REMARK 465     GLY D  1751                                                      
REMARK 465     SER D  1752                                                      
REMARK 465     SER D  1753                                                      
REMARK 465     HIS D  1754                                                      
REMARK 465     HIS D  1755                                                      
REMARK 465     HIS D  1756                                                      
REMARK 465     HIS D  1757                                                      
REMARK 465     HIS D  1758                                                      
REMARK 465     HIS D  1759                                                      
REMARK 465     SER D  1760                                                      
REMARK 465     SER D  1761                                                      
REMARK 465     GLY D  1762                                                      
REMARK 465     LEU D  1763                                                      
REMARK 465     VAL D  1764                                                      
REMARK 465     PRO D  1765                                                      
REMARK 465     ARG D  1766                                                      
REMARK 465     GLY D  1767                                                      
REMARK 465     SER D  1768                                                      
REMARK 465     HIS D  1769                                                      
REMARK 465     MET D  1770                                                      
REMARK 465     ALA D  1771                                                      
REMARK 465     SER D  1772                                                      
REMARK 465     GLU D  1773                                                      
REMARK 465     ASN D  1774                                                      
REMARK 465     PHE D  1775                                                      
REMARK 465     SER D  1776                                                      
REMARK 465     VAL D  1777                                                      
REMARK 465     ALA D  1778                                                      
REMARK 465     THR D  1779                                                      
REMARK 465     GLU D  1780                                                      
REMARK 465     GLU D  1781                                                      
REMARK 465     SER D  1782                                                      
REMARK 465     THR D  1783                                                      
REMARK 465     GLU D  1784                                                      
REMARK 465     PRO D  1785                                                      
REMARK 465     PHE D  1928                                                      
REMARK 465     ARG D  1929                                                      
REMARK 465     GLN D  1930                                                      
REMARK 465     GLN D  1931                                                      
REMARK 465     ALA D  1932                                                      
REMARK 465     GLY D  1933                                                      
REMARK 465     SER D  1934                                                      
REMARK 465     GLY D  1935                                                      
REMARK 465     LEU D  1936                                                      
REMARK 465     SER D  1937                                                      
REMARK 465     GLU D  1938                                                      
REMARK 465     GLU D  1939                                                      
REMARK 465     ASP D  1940                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LYS A  14    CG   CD   CE   NZ                                   
REMARK 470     GLN A  29    CG   CD   OE1  NE2                                  
REMARK 470     TYR A  46    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LEU A  56    CG   CD1  CD2                                       
REMARK 470     ARG A  57    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A  65    CG   CD   CE   NZ                                   
REMARK 470     TYR A  69    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU A  75    CG   CD   OE1  OE2                                  
REMARK 470     TYR A  77    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS A  89    CG   CD   CE   NZ                                   
REMARK 470     LYS A  91    CG   CD   CE   NZ                                   
REMARK 470     TYR A 102    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU A 111    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 122    CG   CD   CE   NZ                                   
REMARK 470     LYS A 128    CG   CD   CE   NZ                                   
REMARK 470     ARG A 131    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 133    CG   CD   CE   NZ                                   
REMARK 470     SER A 138    OG                                                  
REMARK 470     SER A 139    OG                                                  
REMARK 470     ILE A 146    CG1  CG2  CD1                                       
REMARK 470     GLU A 147    CG   CD   OE1  OE2                                  
REMARK 470     MET A 150    CG   SD   CE                                        
REMARK 470     ARG A 152    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C   8    CG   CD   OE1  OE2                                  
REMARK 470     GLU C  12    CG   CD   OE1  OE2                                  
REMARK 470     PHE C  13    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS C  14    CG   CD   CE   NZ                                   
REMARK 470     GLU C  15    CG   CD   OE1  OE2                                  
REMARK 470     PHE C  17    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS C  22    CG   CD   CE   NZ                                   
REMARK 470     THR C  27    OG1  CG2                                            
REMARK 470     THR C  29    OG1  CG2                                            
REMARK 470     LYS C  31    CG   CD   CE   NZ                                   
REMARK 470     ARG C  38    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN C  43    CG   OD1  ND2                                       
REMARK 470     GLU C  46    CG   CD   OE1  OE2                                  
REMARK 470     GLN C  50    CG   CD   OE1  NE2                                  
REMARK 470     ASP C  51    CG   OD1  OD2                                       
REMARK 470     GLU C  55    CG   CD   OE1  OE2                                  
REMARK 470     THR C  63    OG1  CG2                                            
REMARK 470     PHE C  69    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     MET C  72    CG   SD   CE                                        
REMARK 470     ARG C  75    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C  76    CG   CD   CE   NZ                                   
REMARK 470     LYS C  78    CG   CD   CE   NZ                                   
REMARK 470     THR C  80    OG1  CG2                                            
REMARK 470     ASP C  81    CG   OD1  OD2                                       
REMARK 470     GLU C  83    CG   CD   OE1  OE2                                  
REMARK 470     GLU C  84    CG   CD   OE1  OE2                                  
REMARK 470     GLU C  85    CG   CD   OE1  OE2                                  
REMARK 470     ARG C  87    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG C  91    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE C  93    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TYR C 100    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     SER C 102    OG                                                  
REMARK 470     GLU C 105    CG   CD   OE1  OE2                                  
REMARK 470     ARG C 107    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU C 113    CG   CD1  CD2                                       
REMARK 470     GLU C 115    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 116    CG   CD   CE   NZ                                   
REMARK 470     ASP C 119    CG   OD1  OD2                                       
REMARK 470     GLU C 120    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 121    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 123    CG   OD1  OD2                                       
REMARK 470     GLU C 124    CG   CD   OE1  OE2                                  
REMARK 470     ARG C 127    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 128    CG   CD   OE1  OE2                                  
REMARK 470     GLN C 136    CG   CD   OE1  NE2                                  
REMARK 470     TYR C 139    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU C 140    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 141    CG   CD   OE1  OE2                                  
REMARK 470     PHE C 142    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN C 144    CG   CD   OE1  NE2                                  
REMARK 470     THR C 147    OG1  CG2                                            
REMARK 470     TYR D1795    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU D1799    CG   CD   OE1  OE2                                  
REMARK 470     THR D1806    OG1  CG2                                            
REMARK 470     MET D1851    CG   SD   CE                                        
REMARK 470     LEU D1854    CG   CD1  CD2                                       
REMARK 470     PHE D1855    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS D1859    CG   CD   CE   NZ                                   
REMARK 470     ARG D1860    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU D1867    CG   CD   OE1  OE2                                  
REMARK 470     LYS D1872    CG   CD   CE   NZ                                   
REMARK 470     GLN D1874    CG   CD   OE1  NE2                                  
REMARK 470     GLU D1877    CG   CD   OE1  OE2                                  
REMARK 470     LYS D1878    CG   CD   CE   NZ                                   
REMARK 470     LEU D1896    CG   CD1  CD2                                       
REMARK 470     ARG D1897    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG D1898    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS D1899    CG   CD   CE   NZ                                   
REMARK 470     GLU D1901    CG   CD   OE1  OE2                                  
REMARK 470     GLU D1902    CG   CD   OE1  OE2                                  
REMARK 470     SER D1904    OG                                                  
REMARK 470     MET D1906    CG   SD   CE                                        
REMARK 470     GLN D1909    CG   CD   OE1  NE2                                  
REMARK 470     ARG D1910    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE D1912    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG D1913    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG D1914    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU D1916    CG   CD1  CD2                                       
REMARK 470     LEU D1917    CG   CD1  CD2                                       
REMARK 470     GLN D1918    CG   CD   OE1  NE2                                  
REMARK 470     ARG D1919    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS D1922    CG   CD   CE   NZ                                   
REMARK 470     HIS D1923    CG   ND1  CD2  CE1  NE2                             
REMARK 470     PHE D1926    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    PRO A  32      -36.60    -37.25                                   
REMARK 500    PRO A  53       85.44    -68.16                                   
REMARK 500    ASN A  73     -129.24    -72.43                                   
REMARK 500    TYR A  98      -22.80   -147.03                                   
REMARK 500    GLN A 109       88.16    -67.00                                   
REMARK 500    GLN A 110      -19.97    -44.66                                   
REMARK 500    THR C  80      -60.01   -101.48                                   
REMARK 500    GLU C  84       -5.33     78.40                                   
REMARK 500    GLU C  85       46.54   -102.57                                   
REMARK 500    ASP D1839       95.79    -62.02                                   
REMARK 500    SER D1885     -177.43     63.53                                   
REMARK 500    LEU D1896     -109.85     10.02                                   
REMARK 500    ARG D1897      -61.51     -8.90                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA C 202  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP C  21   OD1                                                    
REMARK 620 2 ASP C  23   OD1  55.4                                              
REMARK 620 3 ASP C  25   OD1  59.8  69.3                                        
REMARK 620 4 THR C  27   O    96.7 138.6  70.0                                  
REMARK 620 5 GLU C  32   OE2 128.6 100.4 160.8 120.8                            
REMARK 620 6 GLU C  32   OE1 127.2 148.2 142.1  72.2  51.1                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA C 201  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP C  59   OD2                                                    
REMARK 620 2 ASN C  61   OD1 122.7                                              
REMARK 620 3 THR C  63   O   168.2  59.4                                        
REMARK 620 4 GLU C  68   OE1 107.8 123.4  66.1                                  
REMARK 620 5 GLU C  68   OE2  70.5 131.9  99.4  44.9                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA C 203  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP C  94   OD1                                                    
REMARK 620 2 ASP C  96   OD1  80.8                                              
REMARK 620 3 ASN C  98   OD1  68.1  68.4                                        
REMARK 620 4 TYR C 100   O    77.8 127.1  58.8                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA C 204  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP C 130   OD1                                                    
REMARK 620 2 ASP C 132   OD1 103.5                                              
REMARK 620 3 ASP C 134   OD1 110.9  87.3                                        
REMARK 620 4 GLN C 136   O    97.5 158.8  87.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA C 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA C 202                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA C 203                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CA C 204                  
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 4JPZ   RELATED DB: PDB                                   
DBREF  4JQ0 A  -56   186  UNP    P61328   FGF12_HUMAN      1    243             
DBREF  4JQ0 C    1   149  UNP    P62158   CALM_HUMAN       1    149             
DBREF  4JQ0 D 1773  1940  UNP    Q14524   SCN5A_HUMAN   1773   1940             
SEQADV 4JQ0 MET D 1750  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 GLY D 1751  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 SER D 1752  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 SER D 1753  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 HIS D 1754  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 HIS D 1755  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 HIS D 1756  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 HIS D 1757  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 HIS D 1758  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 HIS D 1759  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 SER D 1760  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 SER D 1761  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 GLY D 1762  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 LEU D 1763  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 VAL D 1764  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 PRO D 1765  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 ARG D 1766  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 GLY D 1767  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 SER D 1768  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 HIS D 1769  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 MET D 1770  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 ALA D 1771  UNP  Q14524              EXPRESSION TAG                 
SEQADV 4JQ0 SER D 1772  UNP  Q14524              EXPRESSION TAG                 
SEQRES   1 A  243  MET ALA ALA ALA ILE ALA SER SER LEU ILE ARG GLN LYS          
SEQRES   2 A  243  ARG GLN ALA ARG GLU SER ASN SER ASP ARG VAL SER ALA          
SEQRES   3 A  243  SER LYS ARG ARG SER SER PRO SER LYS ASP GLY ARG SER          
SEQRES   4 A  243  LEU CYS GLU ARG HIS VAL LEU GLY VAL PHE SER LYS VAL          
SEQRES   5 A  243  ARG PHE CYS SER GLY ARG LYS ARG PRO VAL ARG ARG ARG          
SEQRES   6 A  243  PRO GLU PRO GLN LEU LYS GLY ILE VAL THR ARG LEU PHE          
SEQRES   7 A  243  SER GLN GLN GLY TYR PHE LEU GLN MET HIS PRO ASP GLY          
SEQRES   8 A  243  THR ILE ASP GLY THR LYS ASP GLU ASN SER ASP TYR THR          
SEQRES   9 A  243  LEU PHE ASN LEU ILE PRO VAL GLY LEU ARG VAL VAL ALA          
SEQRES  10 A  243  ILE GLN GLY VAL LYS ALA SER LEU TYR VAL ALA MET ASN          
SEQRES  11 A  243  GLY GLU GLY TYR LEU TYR SER SER ASP VAL PHE THR PRO          
SEQRES  12 A  243  GLU CYS LYS PHE LYS GLU SER VAL PHE GLU ASN TYR TYR          
SEQRES  13 A  243  VAL ILE TYR SER SER THR LEU TYR ARG GLN GLN GLU SER          
SEQRES  14 A  243  GLY ARG ALA TRP PHE LEU GLY LEU ASN LYS GLU GLY GLN          
SEQRES  15 A  243  ILE MET LYS GLY ASN ARG VAL LYS LYS THR LYS PRO SER          
SEQRES  16 A  243  SER HIS PHE VAL PRO LYS PRO ILE GLU VAL CYS MET TYR          
SEQRES  17 A  243  ARG GLU PRO SER LEU HIS GLU ILE GLY GLU LYS GLN GLY          
SEQRES  18 A  243  ARG SER ARG LYS SER SER GLY THR PRO THR MET ASN GLY          
SEQRES  19 A  243  GLY LYS VAL VAL ASN GLN ASP SER THR                          
SEQRES   1 C  149  MET ALA ASP GLN LEU THR GLU GLU GLN ILE ALA GLU PHE          
SEQRES   2 C  149  LYS GLU ALA PHE SER LEU PHE ASP LYS ASP GLY ASP GLY          
SEQRES   3 C  149  THR ILE THR THR LYS GLU LEU GLY THR VAL MET ARG SER          
SEQRES   4 C  149  LEU GLY GLN ASN PRO THR GLU ALA GLU LEU GLN ASP MET          
SEQRES   5 C  149  ILE ASN GLU VAL ASP ALA ASP GLY ASN GLY THR ILE ASP          
SEQRES   6 C  149  PHE PRO GLU PHE LEU THR MET MET ALA ARG LYS MET LYS          
SEQRES   7 C  149  ASP THR ASP SER GLU GLU GLU ILE ARG GLU ALA PHE ARG          
SEQRES   8 C  149  VAL PHE ASP LYS ASP GLY ASN GLY TYR ILE SER ALA ALA          
SEQRES   9 C  149  GLU LEU ARG HIS VAL MET THR ASN LEU GLY GLU LYS LEU          
SEQRES  10 C  149  THR ASP GLU GLU VAL ASP GLU MET ILE ARG GLU ALA ASP          
SEQRES  11 C  149  ILE ASP GLY ASP GLY GLN VAL ASN TYR GLU GLU PHE VAL          
SEQRES  12 C  149  GLN MET MET THR ALA LYS                                      
SEQRES   1 D  191  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 D  191  LEU VAL PRO ARG GLY SER HIS MET ALA SER GLU ASN PHE          
SEQRES   3 D  191  SER VAL ALA THR GLU GLU SER THR GLU PRO LEU SER GLU          
SEQRES   4 D  191  ASP ASP PHE ASP MET PHE TYR GLU ILE TRP GLU LYS PHE          
SEQRES   5 D  191  ASP PRO GLU ALA THR GLN PHE ILE GLU TYR SER VAL LEU          
SEQRES   6 D  191  SER ASP PHE ALA ASP ALA LEU SER GLU PRO LEU ARG ILE          
SEQRES   7 D  191  ALA LYS PRO ASN GLN ILE SER LEU ILE ASN MET ASP LEU          
SEQRES   8 D  191  PRO MET VAL SER GLY ASP ARG ILE HIS CYS MET ASP ILE          
SEQRES   9 D  191  LEU PHE ALA PHE THR LYS ARG VAL LEU GLY GLU SER GLY          
SEQRES  10 D  191  GLU MET ASP ALA LEU LYS ILE GLN MET GLU GLU LYS PHE          
SEQRES  11 D  191  MET ALA ALA ASN PRO SER LYS ILE SER TYR GLU PRO ILE          
SEQRES  12 D  191  THR THR THR LEU ARG ARG LYS HIS GLU GLU VAL SER ALA          
SEQRES  13 D  191  MET VAL ILE GLN ARG ALA PHE ARG ARG HIS LEU LEU GLN          
SEQRES  14 D  191  ARG SER LEU LYS HIS ALA SER PHE LEU PHE ARG GLN GLN          
SEQRES  15 D  191  ALA GLY SER GLY LEU SER GLU GLU ASP                          
HET     CA  C 201       1                                                       
HET     CA  C 202       1                                                       
HET     CA  C 203       1                                                       
HET     CA  C 204       1                                                       
HETNAM      CA CALCIUM ION                                                      
FORMUL   4   CA    4(CA 2+)                                                     
HELIX    1   1 SER A   44  TYR A   46  5                                   3    
HELIX    2   2 THR A   85  CYS A   88  5                                   4    
HELIX    3   3 LYS A  128  VAL A  132  5                                   5    
HELIX    4   4 GLU C    8  ASP C   21  1                                  14    
HELIX    5   5 THR C   29  LEU C   40  1                                  12    
HELIX    6   6 THR C   45  GLU C   55  1                                  11    
HELIX    7   7 ASP C   65  LYS C   78  1                                  14    
HELIX    8   8 ILE C   86  ASP C   94  1                                   9    
HELIX    9   9 ALA C  103  LEU C  113  1                                  11    
HELIX   10  10 THR C  118  ASP C  130  1                                  13    
HELIX   11  11 TYR C  139  THR C  147  1                                   9    
HELIX   12  12 SER D 1787  ASP D 1802  1                                  16    
HELIX   13  13 TYR D 1811  LEU D 1821  1                                  11    
HELIX   14  14 ASN D 1831  MET D 1838  1                                   8    
HELIX   15  15 CYS D 1850  GLY D 1863  1                                  14    
HELIX   16  16 GLY D 1866  ASN D 1883  1                                  18    
HELIX   17  17 LEU D 1896  PHE D 1926  1                                  31    
LINK         OD1 ASP C  21                CA    CA C 202     1555   1555  3.05  
LINK         OD1 ASP C  23                CA    CA C 202     1555   1555  2.66  
LINK         OD1 ASP C  25                CA    CA C 202     1555   1555  2.48  
LINK         O   THR C  27                CA    CA C 202     1555   1555  2.45  
LINK         OE2 GLU C  32                CA    CA C 202     1555   1555  2.37  
LINK         OE1 GLU C  32                CA    CA C 202     1555   1555  2.65  
LINK         OD2 ASP C  59                CA    CA C 201     1555   1555  2.64  
LINK         OD1 ASN C  61                CA    CA C 201     1555   1555  2.40  
LINK         O   THR C  63                CA    CA C 201     1555   1555  2.93  
LINK         OE1 GLU C  68                CA    CA C 201     1555   1555  2.49  
LINK         OE2 GLU C  68                CA    CA C 201     1555   1555  3.07  
LINK         OD1 ASP C  94                CA    CA C 203     1555   1555  2.56  
LINK         OD1 ASP C  96                CA    CA C 203     1555   1555  2.44  
LINK         OD1 ASN C  98                CA    CA C 203     1555   1555  3.13  
LINK         O   TYR C 100                CA    CA C 203     1555   1555  2.37  
LINK         OD1 ASP C 130                CA    CA C 204     1555   1555  1.93  
LINK         OD1 ASP C 132                CA    CA C 204     1555   1555  2.13  
LINK         OD1 ASP C 134                CA    CA C 204     1555   1555  1.97  
LINK         O   GLN C 136                CA    CA C 204     1555   1555  2.27  
CISPEP   1 GLU D 1823    PRO D 1824          0         0.94                     
CISPEP   2 LYS D 1829    PRO D 1830          0        -0.08                     
CISPEP   3 SER D 1844    GLY D 1845          0        -0.41                     
CISPEP   4 SER D 1865    GLY D 1866          0         1.29                     
CISPEP   5 PHE D 1926    LEU D 1927          0        -1.97                     
SITE     1 AC1  4 ASP C  59  ASN C  61  THR C  63  GLU C  68                    
SITE     1 AC2  5 ASP C  21  ASP C  23  ASP C  25  THR C  27                    
SITE     2 AC2  5 GLU C  32                                                     
SITE     1 AC3  4 ASP C  94  ASP C  96  ASN C  98  TYR C 100                    
SITE     1 AC4  4 ASP C 130  ASP C 132  ASP C 134  GLN C 136                    
CRYST1  115.200  115.200  120.110  90.00  90.00 120.00 P 31 2 1      6          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.008681  0.005012  0.000000        0.00000                         
SCALE2      0.000000  0.010023  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.008326        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system