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Database: PDB
Entry: 4O6C
LinkDB: 4O6C
Original site: 4O6C 
HEADER    VIRAL PROTEIN                           20-DEC-13   4O6C              
TITLE     WEST NILE VIRUS NON-STRUCTURAL PROTEIN 1 (NS1) FORM 2 CRYSTAL         
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: NS1;                                                       
COMPND   3 CHAIN: A, B, C, D, E, F;                                             
COMPND   4 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: WEST NILE VIRUS;                                
SOURCE   3 ORGANISM_COMMON: WNV;                                                
SOURCE   4 ORGANISM_TAXID: 11082;                                               
SOURCE   5 STRAIN: NY99;                                                        
SOURCE   6 GENE: NS1;                                                           
SOURCE   7 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE   9 EXPRESSION_SYSTEM_STRAIN: HIGH FIVE;                                 
SOURCE  10 EXPRESSION_SYSTEM_VECTOR_TYPE: BACULOVIRUS;                          
SOURCE  11 EXPRESSION_SYSTEM_PLASMID: PH-AC64-7                                 
KEYWDS    FLAVIVIRUS, NON-STRUCTURAL PROTEIN 1, NS1, VIRAL PROTEIN              
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    D.L.AKEY,J.L.SMITH                                                    
REVDAT   3   22-NOV-17 4O6C    1       REMARK                                   
REVDAT   2   12-MAR-14 4O6C    1       JRNL                                     
REVDAT   1   19-FEB-14 4O6C    0                                                
JRNL        AUTH   D.L.AKEY,W.C.BROWN,S.DUTTA,J.KONWERSKI,J.JOSE,T.J.JURKIW,    
JRNL        AUTH 2 J.DELPROPOSTO,C.M.OGATA,G.SKINIOTIS,R.J.KUHN,J.L.SMITH       
JRNL        TITL   FLAVIVIRUS NS1 STRUCTURES REVEAL SURFACES FOR ASSOCIATIONS   
JRNL        TITL 2 WITH MEMBRANES AND THE IMMUNE SYSTEM.                        
JRNL        REF    SCIENCE                       V. 343   881 2014              
JRNL        REFN                   ISSN 0036-8075                               
JRNL        PMID   24505133                                                     
JRNL        DOI    10.1126/SCIENCE.1247749                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.75 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX 1.8.2_1309                                    
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : TWIN_LSQ_F                                    
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.75                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 48.98                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.980                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 100.0                          
REMARK   3   NUMBER OF REFLECTIONS             : 82983                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.217                           
REMARK   3   R VALUE            (WORKING SET) : 0.215                           
REMARK   3   FREE R VALUE                     : 0.232                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 2.410                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 2004                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 33.9930 -  6.6147    0.97     5782   155  0.1924 0.2598        
REMARK   3     2  6.6147 -  5.2566    0.98     5792   129  0.1857 0.2218        
REMARK   3     3  5.2566 -  4.5939    0.97     5772   150  0.1530 0.1501        
REMARK   3     4  4.5939 -  4.1747    0.97     5767   148  0.1704 0.1745        
REMARK   3     5  4.1747 -  3.8760    0.98     5773   144  0.1956 0.1989        
REMARK   3     6  3.8760 -  3.6477    0.98     5781   142  0.2104 0.2313        
REMARK   3     7  3.6477 -  3.4652    0.98     5786   142  0.2235 0.1902        
REMARK   3     8  3.4652 -  3.3145    0.98     5789   140  0.2396 0.2851        
REMARK   3     9  3.3145 -  3.1870    0.97     5746   148  0.2572 0.2298        
REMARK   3    10  3.1870 -  3.0771    0.98     5813   142  0.2753 0.3038        
REMARK   3    11  3.0771 -  2.9810    0.98     5801   136  0.2939 0.3542        
REMARK   3    12  2.9810 -  2.8958    0.98     5760   144  0.3055 0.3015        
REMARK   3    13  2.8958 -  2.8196    0.98     5744   134  0.3254 0.3043        
REMARK   3    14  2.8196 -  2.7508    0.97     5793   150  0.3644 0.3085        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : NULL             
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 25.900           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 67.80                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 82.91                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: 0.5200                                                   
REMARK   3   OPERATOR: -H,-K,L                                                  
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.004          16494                                  
REMARK   3   ANGLE     :  0.824          22344                                  
REMARK   3   CHIRALITY :  0.031           2466                                  
REMARK   3   PLANARITY :  0.004           2892                                  
REMARK   3   DIHEDRAL  : 14.979           6096                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 32                                         
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 0 THROUGH 31 )                    
REMARK   3    ORIGIN FOR THE GROUP (A):  -4.0096 -89.5054  -2.8452              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5022 T22:   0.2605                                     
REMARK   3      T33:   0.7784 T12:   0.3187                                     
REMARK   3      T13:   0.0337 T23:  -0.0460                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.4086 L22:   0.1377                                     
REMARK   3      L33:   0.4354 L12:  -0.2307                                     
REMARK   3      L13:  -0.2752 L23:   0.1045                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0530 S12:   0.0685 S13:  -0.0283                       
REMARK   3      S21:  -0.0512 S22:  -0.0342 S23:   0.0527                       
REMARK   3      S31:  -0.0049 S32:  -0.0792 S33:   0.1186                       
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 32 THROUGH 51 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -31.4923 -88.9333 -22.1156              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7053 T22:   1.0047                                     
REMARK   3      T33:   0.6944 T12:  -0.1014                                     
REMARK   3      T13:   0.0772 T23:   0.0468                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.1338 L22:   0.1621                                     
REMARK   3      L33:   0.0401 L12:   0.7120                                     
REMARK   3      L13:   0.3566 L23:   0.0811                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0012 S12:  -0.3788 S13:  -0.3189                       
REMARK   3      S21:   0.2107 S22:  -0.1064 S23:  -0.2606                       
REMARK   3      S31:   0.1836 S32:   0.0721 S33:   0.0794                       
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 52 THROUGH 80 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -26.0606 -86.8557 -27.5595              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1646 T22:   0.3945                                     
REMARK   3      T33:   0.4652 T12:  -0.2220                                     
REMARK   3      T13:   0.0506 T23:   0.0444                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.5324 L22:   0.3103                                     
REMARK   3      L33:   0.2546 L12:   0.3190                                     
REMARK   3      L13:   0.2558 L23:   0.1825                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0284 S12:  -0.0120 S13:  -0.0414                       
REMARK   3      S21:  -0.0081 S22:   0.0347 S23:  -0.1168                       
REMARK   3      S31:   0.0142 S32:   0.0924 S33:  -0.0647                       
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 81 THROUGH 125 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): -28.7181 -82.5642 -27.5320              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2051 T22:   0.6268                                     
REMARK   3      T33:   0.4865 T12:  -0.0897                                     
REMARK   3      T13:  -0.0183 T23:   0.1019                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.4912 L22:   1.4949                                     
REMARK   3      L33:   0.1153 L12:   0.8529                                     
REMARK   3      L13:   0.2394 L23:   0.4124                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0022 S12:   0.0541 S13:  -0.1204                       
REMARK   3      S21:  -0.0934 S22:   0.0586 S23:   0.0665                       
REMARK   3      S31:   0.1401 S32:   0.0247 S33:  -0.0006                       
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 126 THROUGH 184 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): -25.5733 -83.0221 -21.1891              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.1325 T22:   0.2512                                     
REMARK   3      T33:   0.6154 T12:  -0.0995                                     
REMARK   3      T13:   0.0385 T23:  -0.0257                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.4096 L22:   0.2457                                     
REMARK   3      L33:   0.6891 L12:   0.3134                                     
REMARK   3      L13:   0.2680 L23:   0.1670                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0769 S12:  -0.0509 S13:  -0.1382                       
REMARK   3      S21:   0.0674 S22:  -0.0119 S23:   0.0370                       
REMARK   3      S31:   0.1462 S32:  -0.0748 S33:   0.0067                       
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 185 THROUGH 283 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  -6.1236 -70.6765 -11.6170              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.2169 T22:  -0.1668                                     
REMARK   3      T33:   0.6224 T12:  -0.0793                                     
REMARK   3      T13:   0.0283 T23:  -0.0030                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:  -0.0008 L22:   0.1692                                     
REMARK   3      L33:   0.0333 L12:   0.0116                                     
REMARK   3      L13:   0.0131 L23:   0.0107                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0077 S12:  -0.0084 S13:  -0.0484                       
REMARK   3      S21:   0.0076 S22:   0.0348 S23:  -0.0996                       
REMARK   3      S31:  -0.0438 S32:   0.0700 S33:   0.1205                       
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: CHAIN 'A' AND (RESID 284 THROUGH 352 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   3.2491 -62.5070 -26.6835              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0001 T22:   0.2433                                     
REMARK   3      T33:   0.6887 T12:   0.0318                                     
REMARK   3      T13:  -0.0525 T23:   0.0465                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0810 L22:   0.0247                                     
REMARK   3      L33:   0.1272 L12:  -0.0213                                     
REMARK   3      L13:   0.0696 L23:   0.0130                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0070 S12:   0.1505 S13:  -0.0190                       
REMARK   3      S21:  -0.0529 S22:  -0.0176 S23:  -0.0569                       
REMARK   3      S31:  -0.0545 S32:   0.0791 S33:  -0.0162                       
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 0 THROUGH 51 )                    
REMARK   3    ORIGIN FOR THE GROUP (A):   0.6241 -83.5166  11.2192              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6608 T22:   0.3903                                     
REMARK   3      T33:   0.6526 T12:   0.0898                                     
REMARK   3      T13:  -0.0236 T23:   0.0751                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0831 L22:   0.0089                                     
REMARK   3      L33:   0.3201 L12:  -0.0265                                     
REMARK   3      L13:  -0.1626 L23:   0.0465                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1192 S12:  -0.1258 S13:  -0.0859                       
REMARK   3      S21:  -0.0232 S22:  -0.0673 S23:  -0.0497                       
REMARK   3      S31:  -0.0812 S32:   0.4185 S33:   0.0408                       
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 52 THROUGH 125 )                  
REMARK   3    ORIGIN FOR THE GROUP (A):   7.2418 -72.0569  28.2528              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.0710 T22:   0.5648                                     
REMARK   3      T33:   0.7123 T12:  -0.1208                                     
REMARK   3      T13:   0.1110 T23:  -0.0663                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.4563 L22:   0.2340                                     
REMARK   3      L33:   0.2759 L12:  -0.5557                                     
REMARK   3      L13:   0.4494 L23:  -0.1212                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0339 S12:  -0.0816 S13:  -0.1011                       
REMARK   3      S21:   0.0128 S22:   0.0680 S23:   0.0074                       
REMARK   3      S31:   0.0421 S32:   0.0147 S33:   0.0099                       
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 126 THROUGH 262 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  -7.5775 -73.1625  14.8570              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:  -0.0852 T22:  -0.2005                                     
REMARK   3      T33:   0.6861 T12:  -0.0659                                     
REMARK   3      T13:   0.0273 T23:   0.0262                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1457 L22:   0.1279                                     
REMARK   3      L33:   0.0654 L12:  -0.0563                                     
REMARK   3      L13:   0.0471 L23:   0.0403                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1230 S12:  -0.0687 S13:  -0.0043                       
REMARK   3      S21:   0.0212 S22:  -0.0247 S23:  -0.0747                       
REMARK   3      S31:  -0.0220 S32:   0.0873 S33:   0.1489                       
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    SELECTION: CHAIN 'B' AND (RESID 263 THROUGH 352 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): -28.5499 -75.5615  26.3602              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2246 T22:   0.4966                                     
REMARK   3      T33:   0.4973 T12:  -0.0009                                     
REMARK   3      T13:   0.0118 T23:   0.0146                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1907 L22:   0.0234                                     
REMARK   3      L33:   0.3901 L12:  -0.0439                                     
REMARK   3      L13:  -0.2661 L23:   0.0626                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0687 S12:  -0.0606 S13:  -0.0713                       
REMARK   3      S21:   0.0601 S22:   0.0758 S23:   0.1288                       
REMARK   3      S31:  -0.1059 S32:  -0.3517 S33:   0.0061                       
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 0 THROUGH 31 )                    
REMARK   3    ORIGIN FOR THE GROUP (A):  -0.0539 -19.4310 -12.1486              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0321 T22:   0.8061                                     
REMARK   3      T33:   1.1508 T12:  -0.0232                                     
REMARK   3      T13:   0.0920 T23:  -0.1037                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1056 L22:   0.3263                                     
REMARK   3      L33:   1.3011 L12:   0.1862                                     
REMARK   3      L13:   0.3669 L23:   0.6476                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0684 S12:  -0.0973 S13:  -0.0044                       
REMARK   3      S21:   0.0007 S22:   0.0145 S23:   0.0274                       
REMARK   3      S31:   0.0383 S32:  -0.1235 S33:   0.0727                       
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 32 THROUGH 51 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -26.5097 -27.7982   6.9165              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8950 T22:   1.0765                                     
REMARK   3      T33:   0.8044 T12:  -0.1046                                     
REMARK   3      T13:  -0.0183 T23:   0.0702                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.1633 L22:   0.0231                                     
REMARK   3      L33:   0.0048 L12:   0.2646                                     
REMARK   3      L13:  -0.1302 L23:  -0.0103                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0300 S12:   0.3921 S13:   0.3690                       
REMARK   3      S21:  -0.1552 S22:  -0.0434 S23:  -0.1356                       
REMARK   3      S31:  -0.1887 S32:   0.0406 S33:   0.0170                       
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 52 THROUGH 80 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -20.7129 -28.3302  12.3406              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7536 T22:   0.9046                                     
REMARK   3      T33:   0.6741 T12:   0.1248                                     
REMARK   3      T13:   0.0491 T23:  -0.0123                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.0253 L22:   0.2935                                     
REMARK   3      L33:   0.6261 L12:  -0.7442                                     
REMARK   3      L13:  -0.9425 L23:   0.2959                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0879 S12:  -0.0233 S13:   0.1712                       
REMARK   3      S21:  -0.0244 S22:   0.0110 S23:  -0.1775                       
REMARK   3      S31:  -0.1182 S32:   0.0989 S33:  -0.0731                       
REMARK   3   TLS GROUP : 15                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 81 THROUGH 125 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): -22.1098 -33.1897  12.2783              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6740 T22:   0.9766                                     
REMARK   3      T33:   0.7255 T12:   0.1045                                     
REMARK   3      T13:  -0.0353 T23:   0.0165                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.0056 L22:   1.0571                                     
REMARK   3      L33:   0.0934 L12:  -1.0297                                     
REMARK   3      L13:  -0.2977 L23:   0.3067                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0631 S12:  -0.0891 S13:   0.0750                       
REMARK   3      S21:  -0.0311 S22:   0.0026 S23:  -0.0073                       
REMARK   3      S31:  -0.0152 S32:   0.1021 S33:   0.0035                       
REMARK   3   TLS GROUP : 16                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 126 THROUGH 262 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  -7.3594 -35.5848  -1.0002              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6214 T22:   0.4607                                     
REMARK   3      T33:   0.4307 T12:   0.0332                                     
REMARK   3      T13:   0.0113 T23:  -0.0237                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.4766 L22:   0.2154                                     
REMARK   3      L33:   0.7128 L12:  -0.2282                                     
REMARK   3      L13:  -0.3914 L23:   0.3113                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0667 S12:  -0.1425 S13:   0.1739                       
REMARK   3      S21:  -0.0988 S22:   0.1501 S23:   0.0940                       
REMARK   3      S31:  -0.2477 S32:  -0.2334 S33:   0.0123                       
REMARK   3   TLS GROUP : 17                                                     
REMARK   3    SELECTION: CHAIN 'C' AND (RESID 263 THROUGH 352 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  12.7022 -42.1497  10.5054              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6530 T22:   0.7276                                     
REMARK   3      T33:   0.5045 T12:  -0.0391                                     
REMARK   3      T13:   0.0831 T23:  -0.0070                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1276 L22:   0.1054                                     
REMARK   3      L33:   0.4281 L12:  -0.0911                                     
REMARK   3      L13:   0.2135 L23:  -0.2049                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0553 S12:  -0.0536 S13:  -0.0298                       
REMARK   3      S21:   0.0328 S22:   0.0529 S23:  -0.2728                       
REMARK   3      S31:  -0.0092 S32:   0.1558 S33:   0.0095                       
REMARK   3   TLS GROUP : 18                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 0 THROUGH 31 )                    
REMARK   3    ORIGIN FOR THE GROUP (A):  -3.6933 -19.0297 -18.7659              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.2125 T22:   0.8619                                     
REMARK   3      T33:   1.2073 T12:   0.1152                                     
REMARK   3      T13:   0.1514 T23:   0.0730                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0412 L22:   0.3641                                     
REMARK   3      L33:   1.3659 L12:  -0.1129                                     
REMARK   3      L13:   0.2306 L23:  -0.6975                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0771 S12:   0.0737 S13:   0.0005                       
REMARK   3      S21:  -0.0246 S22:  -0.0063 S23:   0.0367                       
REMARK   3      S31:   0.0705 S32:   0.1507 S33:   0.0389                       
REMARK   3   TLS GROUP : 19                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 32 THROUGH 51 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  21.0220 -31.4945 -37.8208              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8479 T22:   1.0612                                     
REMARK   3      T33:   0.7915 T12:  -0.2060                                     
REMARK   3      T13:  -0.0217 T23:   0.0501                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.4249 L22:   0.2360                                     
REMARK   3      L33:   0.0425 L12:  -0.8869                                     
REMARK   3      L13:  -0.3657 L23:   0.0991                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0007 S12:  -0.3625 S13:   0.3452                       
REMARK   3      S21:   0.1583 S22:   0.1559 S23:   0.0464                       
REMARK   3      S31:  -0.1342 S32:   0.0095 S33:  -0.1069                       
REMARK   3   TLS GROUP : 20                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 52 THROUGH 125 )                  
REMARK   3    ORIGIN FOR THE GROUP (A):  15.4820 -33.5569 -43.2521              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6562 T22:   0.9463                                     
REMARK   3      T33:   0.6703 T12:  -0.1477                                     
REMARK   3      T13:   0.0447 T23:  -0.0878                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.5787 L22:   0.3295                                     
REMARK   3      L33:   0.3330 L12:   0.7015                                     
REMARK   3      L13:  -0.7110 L23:  -0.3167                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0024 S12:   0.1352 S13:   0.0705                       
REMARK   3      S21:   0.0202 S22:  -0.0320 S23:  -0.0272                       
REMARK   3      S31:  -0.0536 S32:  -0.0304 S33:  -0.0051                       
REMARK   3   TLS GROUP : 21                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 126 THROUGH 262 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):   0.8795 -36.1457 -29.9485              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7177 T22:   0.4786                                     
REMARK   3      T33:   0.3887 T12:  -0.0672                                     
REMARK   3      T13:   0.0648 T23:   0.0115                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.6357 L22:   0.1254                                     
REMARK   3      L33:   0.7579 L12:   0.2353                                     
REMARK   3      L13:  -0.4409 L23:  -0.2297                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0187 S12:   0.1330 S13:   0.0597                       
REMARK   3      S21:  -0.0426 S22:   0.0806 S23:  -0.1044                       
REMARK   3      S31:  -0.2165 S32:   0.0954 S33:  -0.0165                       
REMARK   3   TLS GROUP : 22                                                     
REMARK   3    SELECTION: CHAIN 'D' AND (RESID 263 THROUGH 352 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): -20.0064 -39.3976 -41.3706              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6832 T22:   0.7050                                     
REMARK   3      T33:   0.5478 T12:   0.0661                                     
REMARK   3      T13:   0.0364 T23:   0.0030                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1574 L22:   0.0672                                     
REMARK   3      L33:   0.4024 L12:   0.0817                                     
REMARK   3      L13:   0.2460 L23:   0.1493                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0014 S12:   0.0004 S13:   0.0719                       
REMARK   3      S21:  -0.1189 S22:   0.0269 S23:   0.1086                       
REMARK   3      S31:   0.0408 S32:  -0.1919 S33:   0.0175                       
REMARK   3   TLS GROUP : 23                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 0 THROUGH 31 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): -79.9668 -66.9100  28.7314              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0880 T22:   1.0530                                     
REMARK   3      T33:   1.1386 T12:   0.2620                                     
REMARK   3      T13:   0.1568 T23:   0.0075                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0653 L22:   0.4121                                     
REMARK   3      L33:   1.4806 L12:  -0.1613                                     
REMARK   3      L13:  -0.3043 L23:   0.7806                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0563 S12:  -0.0663 S13:  -0.0089                       
REMARK   3      S21:   0.0296 S22:  -0.1165 S23:   0.0299                       
REMARK   3      S31:   0.2005 S32:  -0.0386 S33:   0.0448                       
REMARK   3   TLS GROUP : 24                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 32 THROUGH 51 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -89.4042 -92.9235  47.8596              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9857 T22:   1.2468                                     
REMARK   3      T33:   0.9874 T12:  -0.1124                                     
REMARK   3      T13:   0.0137 T23:   0.0284                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.2141 L22:   2.8342                                     
REMARK   3      L33:   0.1363 L12:   1.8404                                     
REMARK   3      L13:  -0.3924 L23:  -0.6167                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0780 S12:   0.3374 S13:   0.2976                       
REMARK   3      S21:  -0.2592 S22:   0.0598 S23:   0.2428                       
REMARK   3      S31:  -0.0552 S32:  -0.1390 S33:  -0.0302                       
REMARK   3   TLS GROUP : 25                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 52 THROUGH 125 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): -84.0696 -90.5731  53.2871              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8145 T22:   1.2680                                     
REMARK   3      T33:   0.7483 T12:  -0.4173                                     
REMARK   3      T13:  -0.0228 T23:   0.1280                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.1435 L22:   0.0494                                     
REMARK   3      L33:   0.0525 L12:   0.2964                                     
REMARK   3      L13:  -0.2810 L23:  -0.0500                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0224 S12:  -0.0939 S13:   0.0495                       
REMARK   3      S21:  -0.0165 S22:  -0.0715 S23:   0.0958                       
REMARK   3      S31:   0.0106 S32:   0.0730 S33:   0.0176                       
REMARK   3   TLS GROUP : 26                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 126 THROUGH 262 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): -71.6108 -82.4368  39.9833              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3819 T22:   0.9857                                     
REMARK   3      T33:   0.4719 T12:  -0.1577                                     
REMARK   3      T13:   0.0476 T23:   0.0999                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.4933 L22:   0.1145                                     
REMARK   3      L33:   0.6258 L12:   0.1770                                     
REMARK   3      L13:  -0.4411 L23:  -0.0538                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0146 S12:  -0.0008 S13:  -0.0751                       
REMARK   3      S21:   0.2006 S22:  -0.0346 S23:   0.2384                       
REMARK   3      S31:   0.3147 S32:  -0.3086 S33:   0.0247                       
REMARK   3   TLS GROUP : 27                                                     
REMARK   3    SELECTION: CHAIN 'E' AND (RESID 263 THROUGH 352 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): -54.2078 -70.4603  51.5581              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5352 T22:   0.7505                                     
REMARK   3      T33:   0.3729 T12:  -0.1129                                     
REMARK   3      T13:  -0.0176 T23:   0.0960                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.2078 L22:   0.0154                                     
REMARK   3      L33:   0.3860 L12:   0.0403                                     
REMARK   3      L13:   0.2740 L23:   0.0538                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0252 S12:  -0.0760 S13:   0.1557                       
REMARK   3      S21:   0.0179 S22:   0.0364 S23:  -0.0975                       
REMARK   3      S31:  -0.1923 S32:   0.1857 S33:   0.0089                       
REMARK   3   TLS GROUP : 28                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 0 THROUGH 31 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): -82.3110 -69.1675  22.2244              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.9033 T22:   0.9178                                     
REMARK   3      T33:   1.1047 T12:   0.2320                                     
REMARK   3      T13:   0.0320 T23:   0.0846                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3976 L22:   0.0562                                     
REMARK   3      L33:   1.4622 L12:  -0.1365                                     
REMARK   3      L13:   0.7607 L23:  -0.2718                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1478 S12:   0.0013 S13:   0.0141                       
REMARK   3      S21:  -0.0609 S22:   0.0756 S23:  -0.0331                       
REMARK   3      S31:  -0.0664 S32:   0.1575 S33:   0.0866                       
REMARK   3   TLS GROUP : 29                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 32 THROUGH 51 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -57.1700 -57.4408   3.2433              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8868 T22:   1.0854                                     
REMARK   3      T33:   0.8114 T12:  -0.0715                                     
REMARK   3      T13:  -0.0432 T23:   0.0243                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.3369 L22:   1.3951                                     
REMARK   3      L33:   0.0297 L12:   1.8006                                     
REMARK   3      L13:  -0.2632 L23:  -0.2058                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1598 S12:  -0.2581 S13:   0.1696                       
REMARK   3      S21:   0.3001 S22:  -0.0344 S23:   0.2821                       
REMARK   3      S31:  -0.1550 S32:  -0.1313 S33:  -0.1208                       
REMARK   3   TLS GROUP : 30                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 52 THROUGH 125 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): -58.9802 -63.0334  -2.2083              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6211 T22:   0.6586                                     
REMARK   3      T33:   0.6101 T12:  -0.1253                                     
REMARK   3      T13:  -0.0361 T23:   0.1108                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1308 L22:   0.8299                                     
REMARK   3      L33:   0.1807 L12:  -0.0311                                     
REMARK   3      L13:  -0.1390 L23:  -0.1273                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0461 S12:   0.0143 S13:   0.0151                       
REMARK   3      S21:  -0.1105 S22:   0.0023 S23:   0.0491                       
REMARK   3      S31:  -0.0526 S32:  -0.0459 S33:   0.0109                       
REMARK   3   TLS GROUP : 31                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 126 THROUGH 262 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): -66.0870 -76.1344  11.0548              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5631 T22:   0.6733                                     
REMARK   3      T33:   0.4255 T12:  -0.0713                                     
REMARK   3      T13:  -0.0652 T23:   0.0343                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.1379 L22:   0.5714                                     
REMARK   3      L33:   0.7277 L12:   0.1443                                     
REMARK   3      L13:  -0.0798 L23:  -0.4262                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0291 S12:  -0.0501 S13:   0.0084                       
REMARK   3      S21:   0.0192 S22:   0.0569 S23:  -0.0648                       
REMARK   3      S31:   0.0579 S32:  -0.1367 S33:  -0.0158                       
REMARK   3   TLS GROUP : 32                                                     
REMARK   3    SELECTION: CHAIN 'F' AND (RESID 263 THROUGH 352 )                 
REMARK   3    ORIGIN FOR THE GROUP (A): -76.5926 -94.4404  -0.4322              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.8075 T22:   0.8848                                     
REMARK   3      T33:   0.6113 T12:  -0.2002                                     
REMARK   3      T13:  -0.0406 T23:   0.0189                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.0079 L22:   0.1878                                     
REMARK   3      L33:   0.3868 L12:   0.0205                                     
REMARK   3      L13:   0.0251 L23:   0.2660                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0163 S12:   0.0376 S13:  -0.1089                       
REMARK   3      S21:   0.0055 S22:   0.0018 S23:   0.0735                       
REMARK   3      S31:   0.1846 S32:  -0.0382 S33:   0.0279                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 4O6C COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 06-JAN-14.                  
REMARK 100 THE DEPOSITION ID IS D_1000084097.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 12-OCT-12                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 5.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 23-ID-D                            
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : NULL                               
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.0332                             
REMARK 200  MONOCHROMATOR                  : DOUBLE CRYSTAL MONOCHROMATOR       
REMARK 200  OPTICS                         : K-B PAIR OF BIOMORPH MIRRORS       
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : MARMOSAIC 300                      
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : DENZO                              
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK                          
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 82996                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.750                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.000                              
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 100.0                              
REMARK 200  DATA REDUNDANCY                : 5.900                              
REMARK 200  R MERGE                    (I) : 0.24400                            
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 7.4000                             
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.75                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.80                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 100.0                              
REMARK 200  DATA REDUNDANCY IN SHELL       : 5.60                               
REMARK 200  R MERGE FOR SHELL          (I) : 2.41000                            
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 1.000                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: MOLREP                                                
REMARK 200 STARTING MODEL: PDB ENTRY 4O6D                                       
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 61.85                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.22                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 25% PEG 3000, 5% GLYCEROL, 20 MM         
REMARK 280  SODIUM CITRATE PH 5.5, VAPOR DIFFUSION, SITTING DROP,               
REMARK 280  TEMPERATURE 278K                                                    
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 3                              
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -Y,X-Y,Z                                                
REMARK 290       3555   -X+Y,-X,Z                                               
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -0.500000 -0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   3 -0.500000  0.866025  0.000000        0.00000            
REMARK 290   SMTRY2   3 -0.866025 -0.500000  0.000000        0.00000            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2, 3                                                 
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 5350 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 30650 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -17.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 5350 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 30470 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -21.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 3                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 5400 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 30500 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -22.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E, F                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     ALA A   -24                                                      
REMARK 465     GLU A   -23                                                      
REMARK 465     HIS A   -22                                                      
REMARK 465     HIS A   -21                                                      
REMARK 465     HIS A   -20                                                      
REMARK 465     HIS A   -19                                                      
REMARK 465     HIS A   -18                                                      
REMARK 465     HIS A   -17                                                      
REMARK 465     SER A   -16                                                      
REMARK 465     SER A   -15                                                      
REMARK 465     GLY A   -14                                                      
REMARK 465     VAL A   -13                                                      
REMARK 465     ASP A   -12                                                      
REMARK 465     LEU A   -11                                                      
REMARK 465     GLY A   -10                                                      
REMARK 465     THR A    -9                                                      
REMARK 465     GLU A    -8                                                      
REMARK 465     ASN A    -7                                                      
REMARK 465     LEU A    -6                                                      
REMARK 465     TYR A    -5                                                      
REMARK 465     PHE A    -4                                                      
REMARK 465     GLN A    -3                                                      
REMARK 465     SER A    -2                                                      
REMARK 465     ASN A    -1                                                      
REMARK 465     LYS A   110                                                      
REMARK 465     LEU A   111                                                      
REMARK 465     GLU A   112                                                      
REMARK 465     ILE A   113                                                      
REMARK 465     GLY A   114                                                      
REMARK 465     TRP A   115                                                      
REMARK 465     LYS A   116                                                      
REMARK 465     ALA A   117                                                      
REMARK 465     TRP A   118                                                      
REMARK 465     GLY A   119                                                      
REMARK 465     LYS A   120                                                      
REMARK 465     SER A   121                                                      
REMARK 465     ILE A   122                                                      
REMARK 465     LEU A   123                                                      
REMARK 465     PHE A   124                                                      
REMARK 465     ALA B   -24                                                      
REMARK 465     GLU B   -23                                                      
REMARK 465     HIS B   -22                                                      
REMARK 465     HIS B   -21                                                      
REMARK 465     HIS B   -20                                                      
REMARK 465     HIS B   -19                                                      
REMARK 465     HIS B   -18                                                      
REMARK 465     HIS B   -17                                                      
REMARK 465     SER B   -16                                                      
REMARK 465     SER B   -15                                                      
REMARK 465     GLY B   -14                                                      
REMARK 465     VAL B   -13                                                      
REMARK 465     ASP B   -12                                                      
REMARK 465     LEU B   -11                                                      
REMARK 465     GLY B   -10                                                      
REMARK 465     THR B    -9                                                      
REMARK 465     GLU B    -8                                                      
REMARK 465     ASN B    -7                                                      
REMARK 465     LEU B    -6                                                      
REMARK 465     TYR B    -5                                                      
REMARK 465     PHE B    -4                                                      
REMARK 465     GLN B    -3                                                      
REMARK 465     SER B    -2                                                      
REMARK 465     ASN B    -1                                                      
REMARK 465     LYS B   110                                                      
REMARK 465     LEU B   111                                                      
REMARK 465     GLU B   112                                                      
REMARK 465     ILE B   113                                                      
REMARK 465     GLY B   114                                                      
REMARK 465     TRP B   115                                                      
REMARK 465     LYS B   116                                                      
REMARK 465     ALA B   117                                                      
REMARK 465     TRP B   118                                                      
REMARK 465     GLY B   119                                                      
REMARK 465     LYS B   120                                                      
REMARK 465     SER B   121                                                      
REMARK 465     ILE B   122                                                      
REMARK 465     LEU B   123                                                      
REMARK 465     PHE B   124                                                      
REMARK 465     ALA C   -24                                                      
REMARK 465     GLU C   -23                                                      
REMARK 465     HIS C   -22                                                      
REMARK 465     HIS C   -21                                                      
REMARK 465     HIS C   -20                                                      
REMARK 465     HIS C   -19                                                      
REMARK 465     HIS C   -18                                                      
REMARK 465     HIS C   -17                                                      
REMARK 465     SER C   -16                                                      
REMARK 465     SER C   -15                                                      
REMARK 465     GLY C   -14                                                      
REMARK 465     VAL C   -13                                                      
REMARK 465     ASP C   -12                                                      
REMARK 465     LEU C   -11                                                      
REMARK 465     GLY C   -10                                                      
REMARK 465     THR C    -9                                                      
REMARK 465     GLU C    -8                                                      
REMARK 465     ASN C    -7                                                      
REMARK 465     LEU C    -6                                                      
REMARK 465     TYR C    -5                                                      
REMARK 465     PHE C    -4                                                      
REMARK 465     GLN C    -3                                                      
REMARK 465     SER C    -2                                                      
REMARK 465     ASN C    -1                                                      
REMARK 465     LYS C   110                                                      
REMARK 465     LEU C   111                                                      
REMARK 465     GLU C   112                                                      
REMARK 465     ILE C   113                                                      
REMARK 465     GLY C   114                                                      
REMARK 465     TRP C   115                                                      
REMARK 465     LYS C   116                                                      
REMARK 465     ALA C   117                                                      
REMARK 465     TRP C   118                                                      
REMARK 465     GLY C   119                                                      
REMARK 465     LYS C   120                                                      
REMARK 465     SER C   121                                                      
REMARK 465     ILE C   122                                                      
REMARK 465     LEU C   123                                                      
REMARK 465     PHE C   124                                                      
REMARK 465     ALA D   -24                                                      
REMARK 465     GLU D   -23                                                      
REMARK 465     HIS D   -22                                                      
REMARK 465     HIS D   -21                                                      
REMARK 465     HIS D   -20                                                      
REMARK 465     HIS D   -19                                                      
REMARK 465     HIS D   -18                                                      
REMARK 465     HIS D   -17                                                      
REMARK 465     SER D   -16                                                      
REMARK 465     SER D   -15                                                      
REMARK 465     GLY D   -14                                                      
REMARK 465     VAL D   -13                                                      
REMARK 465     ASP D   -12                                                      
REMARK 465     LEU D   -11                                                      
REMARK 465     GLY D   -10                                                      
REMARK 465     THR D    -9                                                      
REMARK 465     GLU D    -8                                                      
REMARK 465     ASN D    -7                                                      
REMARK 465     LEU D    -6                                                      
REMARK 465     TYR D    -5                                                      
REMARK 465     PHE D    -4                                                      
REMARK 465     GLN D    -3                                                      
REMARK 465     SER D    -2                                                      
REMARK 465     ASN D    -1                                                      
REMARK 465     LYS D   110                                                      
REMARK 465     LEU D   111                                                      
REMARK 465     GLU D   112                                                      
REMARK 465     ILE D   113                                                      
REMARK 465     GLY D   114                                                      
REMARK 465     TRP D   115                                                      
REMARK 465     LYS D   116                                                      
REMARK 465     ALA D   117                                                      
REMARK 465     TRP D   118                                                      
REMARK 465     GLY D   119                                                      
REMARK 465     LYS D   120                                                      
REMARK 465     SER D   121                                                      
REMARK 465     ILE D   122                                                      
REMARK 465     LEU D   123                                                      
REMARK 465     PHE D   124                                                      
REMARK 465     ALA E   -24                                                      
REMARK 465     GLU E   -23                                                      
REMARK 465     HIS E   -22                                                      
REMARK 465     HIS E   -21                                                      
REMARK 465     HIS E   -20                                                      
REMARK 465     HIS E   -19                                                      
REMARK 465     HIS E   -18                                                      
REMARK 465     HIS E   -17                                                      
REMARK 465     SER E   -16                                                      
REMARK 465     SER E   -15                                                      
REMARK 465     GLY E   -14                                                      
REMARK 465     VAL E   -13                                                      
REMARK 465     ASP E   -12                                                      
REMARK 465     LEU E   -11                                                      
REMARK 465     GLY E   -10                                                      
REMARK 465     THR E    -9                                                      
REMARK 465     GLU E    -8                                                      
REMARK 465     ASN E    -7                                                      
REMARK 465     LEU E    -6                                                      
REMARK 465     TYR E    -5                                                      
REMARK 465     PHE E    -4                                                      
REMARK 465     GLN E    -3                                                      
REMARK 465     SER E    -2                                                      
REMARK 465     ASN E    -1                                                      
REMARK 465     LYS E   110                                                      
REMARK 465     LEU E   111                                                      
REMARK 465     GLU E   112                                                      
REMARK 465     ILE E   113                                                      
REMARK 465     GLY E   114                                                      
REMARK 465     TRP E   115                                                      
REMARK 465     LYS E   116                                                      
REMARK 465     ALA E   117                                                      
REMARK 465     TRP E   118                                                      
REMARK 465     GLY E   119                                                      
REMARK 465     LYS E   120                                                      
REMARK 465     SER E   121                                                      
REMARK 465     ILE E   122                                                      
REMARK 465     LEU E   123                                                      
REMARK 465     PHE E   124                                                      
REMARK 465     ALA F   -24                                                      
REMARK 465     GLU F   -23                                                      
REMARK 465     HIS F   -22                                                      
REMARK 465     HIS F   -21                                                      
REMARK 465     HIS F   -20                                                      
REMARK 465     HIS F   -19                                                      
REMARK 465     HIS F   -18                                                      
REMARK 465     HIS F   -17                                                      
REMARK 465     SER F   -16                                                      
REMARK 465     SER F   -15                                                      
REMARK 465     GLY F   -14                                                      
REMARK 465     VAL F   -13                                                      
REMARK 465     ASP F   -12                                                      
REMARK 465     LEU F   -11                                                      
REMARK 465     GLY F   -10                                                      
REMARK 465     THR F    -9                                                      
REMARK 465     GLU F    -8                                                      
REMARK 465     ASN F    -7                                                      
REMARK 465     LEU F    -6                                                      
REMARK 465     TYR F    -5                                                      
REMARK 465     PHE F    -4                                                      
REMARK 465     GLN F    -3                                                      
REMARK 465     SER F    -2                                                      
REMARK 465     ASN F    -1                                                      
REMARK 465     LYS F   110                                                      
REMARK 465     LEU F   111                                                      
REMARK 465     GLU F   112                                                      
REMARK 465     ILE F   113                                                      
REMARK 465     GLY F   114                                                      
REMARK 465     TRP F   115                                                      
REMARK 465     LYS F   116                                                      
REMARK 465     ALA F   117                                                      
REMARK 465     TRP F   118                                                      
REMARK 465     GLY F   119                                                      
REMARK 465     LYS F   120                                                      
REMARK 465     SER F   121                                                      
REMARK 465     ILE F   122                                                      
REMARK 465     LEU F   123                                                      
REMARK 465     PHE F   124                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OE2  GLU C   139     OG1  THR C   145              2.06            
REMARK 500   NH1  ARG B    31     O    THR B   163              2.07            
REMARK 500   OE2  GLU B   139     OG1  THR B   145              2.09            
REMARK 500   NH1  ARG D    31     O    THR D   163              2.11            
REMARK 500   OE2  GLU F   139     OG1  THR F   145              2.11            
REMARK 500   OG1  THR B   283     OH   TYR B   331              2.12            
REMARK 500   OG1  THR D   283     OH   TYR D   331              2.12            
REMARK 500   OE2  GLU A   139     OG1  THR A   145              2.12            
REMARK 500   NH1  ARG E    31     O    THR E   163              2.12            
REMARK 500   OE2  GLU D   139     OG1  THR D   145              2.13            
REMARK 500   NH1  ARG F    31     O    THR F   163              2.13            
REMARK 500   O    PRO F   226     OG1  THR F   230              2.13            
REMARK 500   NH1  ARG A    31     O    THR A   163              2.13            
REMARK 500   OG1  THR F   283     OH   TYR F   331              2.14            
REMARK 500   OE2  GLU E   139     OG1  THR E   145              2.14            
REMARK 500   NH1  ARG A    58     O    GLY A   137              2.14            
REMARK 500   OG1  THR A   283     OH   TYR A   331              2.15            
REMARK 500   OG1  THR E   283     OH   TYR E   331              2.16            
REMARK 500   NH2  ARG A   103     OD1  ASN A   175              2.16            
REMARK 500   NH2  ARG D   103     OD1  ASN D   175              2.16            
REMARK 500   OE2  GLU C    26     NH2  ARG C   214              2.17            
REMARK 500   OG1  THR C   283     OH   TYR C   331              2.17            
REMARK 500   NH2  ARG B   103     OD1  ASN B   175              2.17            
REMARK 500   O    PRO D   226     OG1  THR D   230              2.18            
REMARK 500   NE2  GLN C   263     OE1  GLU C   334              2.18            
REMARK 500   OG   SER B   288     OG   SER B   290              2.18            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    THR A 108      148.40     60.73                                   
REMARK 500    ASP A 136     -150.03     58.30                                   
REMARK 500    ASN A 207     -108.91    -92.06                                   
REMARK 500    LYS A 261     -159.82   -122.64                                   
REMARK 500    ASP A 278     -175.61   -170.25                                   
REMARK 500    THR B 108      146.90     60.85                                   
REMARK 500    ASP B 136     -149.54     58.31                                   
REMARK 500    ASN B 207     -107.98    -93.30                                   
REMARK 500    LYS B 261     -160.15   -122.19                                   
REMARK 500    ASP B 278     -174.62   -170.29                                   
REMARK 500    ARG B 314      -65.31    -90.58                                   
REMARK 500    THR C 108      148.63     61.88                                   
REMARK 500    ASP C 136     -147.99     57.58                                   
REMARK 500    ASP C 197     -158.52   -141.23                                   
REMARK 500    ASN C 207     -108.72    -91.24                                   
REMARK 500    LYS C 261     -162.48   -121.52                                   
REMARK 500    ARG C 314      -64.84    -90.05                                   
REMARK 500    THR D 108      146.28     59.60                                   
REMARK 500    ASP D 136     -148.65     57.45                                   
REMARK 500    ASP D 197     -158.63   -142.37                                   
REMARK 500    ASN D 207     -109.23    -91.22                                   
REMARK 500    ILE D 242      -70.33    -56.09                                   
REMARK 500    LYS D 261     -161.15   -122.15                                   
REMARK 500    ASP D 278     -175.25   -170.24                                   
REMARK 500    THR E 108      147.43     62.84                                   
REMARK 500    ASP E 136     -149.85     57.22                                   
REMARK 500    ASP E 197     -159.44   -141.77                                   
REMARK 500    ASN E 207     -108.88    -90.30                                   
REMARK 500    LYS E 261     -160.59   -121.98                                   
REMARK 500    ASP E 278     -174.13   -170.11                                   
REMARK 500    THR F 108      149.08     59.33                                   
REMARK 500    ASP F 136     -148.33     57.98                                   
REMARK 500    ASP F 197     -157.77   -142.06                                   
REMARK 500    ASN F 207     -108.66    -91.02                                   
REMARK 500    ILE F 242      -70.41    -55.93                                   
REMARK 500    LYS F 261     -161.35   -122.25                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAG A 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A 402                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAG B 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAG C 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 C 402                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAG D 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAG E 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE NAG F 401                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 F 402                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 4O6B   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 4O6D   RELATED DB: PDB                                   
DBREF  4O6C A  -17   352  UNP    U3N977   U3N977_WNV     790   1143             
DBREF  4O6C B  -17   352  UNP    U3N977   U3N977_WNV     790   1143             
DBREF  4O6C C  -17   352  UNP    U3N977   U3N977_WNV     790   1143             
DBREF  4O6C D  -17   352  UNP    U3N977   U3N977_WNV     790   1143             
DBREF  4O6C E  -17   352  UNP    U3N977   U3N977_WNV     790   1143             
DBREF  4O6C F  -17   352  UNP    U3N977   U3N977_WNV     790   1143             
SEQADV 4O6C ALA A  -24  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLU A  -23  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS A  -22  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS A  -21  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS A  -20  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS A  -19  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS A  -18  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER A  -16  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER A  -15  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLY A  -14  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C VAL A  -13  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASP A  -12  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C LEU A  -11  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLY A  -10  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C THR A   -9  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLU A   -8  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASN A   -7  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C LEU A   -6  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C TYR A   -5  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C PHE A   -4  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLN A   -3  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER A   -2  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASN A   -1  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ALA B  -24  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLU B  -23  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS B  -22  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS B  -21  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS B  -20  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS B  -19  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS B  -18  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER B  -16  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER B  -15  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLY B  -14  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C VAL B  -13  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASP B  -12  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C LEU B  -11  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLY B  -10  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C THR B   -9  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLU B   -8  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASN B   -7  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C LEU B   -6  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C TYR B   -5  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C PHE B   -4  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLN B   -3  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER B   -2  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASN B   -1  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ALA C  -24  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLU C  -23  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS C  -22  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS C  -21  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS C  -20  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS C  -19  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS C  -18  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER C  -16  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER C  -15  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLY C  -14  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C VAL C  -13  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASP C  -12  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C LEU C  -11  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLY C  -10  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C THR C   -9  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLU C   -8  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASN C   -7  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C LEU C   -6  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C TYR C   -5  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C PHE C   -4  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLN C   -3  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER C   -2  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASN C   -1  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ALA D  -24  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLU D  -23  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS D  -22  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS D  -21  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS D  -20  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS D  -19  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS D  -18  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER D  -16  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER D  -15  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLY D  -14  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C VAL D  -13  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASP D  -12  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C LEU D  -11  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLY D  -10  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C THR D   -9  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLU D   -8  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASN D   -7  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C LEU D   -6  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C TYR D   -5  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C PHE D   -4  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLN D   -3  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER D   -2  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASN D   -1  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ALA E  -24  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLU E  -23  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS E  -22  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS E  -21  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS E  -20  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS E  -19  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS E  -18  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER E  -16  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER E  -15  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLY E  -14  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C VAL E  -13  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASP E  -12  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C LEU E  -11  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLY E  -10  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C THR E   -9  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLU E   -8  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASN E   -7  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C LEU E   -6  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C TYR E   -5  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C PHE E   -4  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLN E   -3  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER E   -2  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASN E   -1  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ALA F  -24  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLU F  -23  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS F  -22  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS F  -21  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS F  -20  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS F  -19  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C HIS F  -18  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER F  -16  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER F  -15  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLY F  -14  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C VAL F  -13  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASP F  -12  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C LEU F  -11  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLY F  -10  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C THR F   -9  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLU F   -8  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASN F   -7  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C LEU F   -6  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C TYR F   -5  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C PHE F   -4  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C GLN F   -3  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C SER F   -2  UNP  U3N977              EXPRESSION TAG                 
SEQADV 4O6C ASN F   -1  UNP  U3N977              EXPRESSION TAG                 
SEQRES   1 A  377  ALA GLU HIS HIS HIS HIS HIS HIS SER SER GLY VAL ASP          
SEQRES   2 A  377  LEU GLY THR GLU ASN LEU TYR PHE GLN SER ASN ALA ASP          
SEQRES   3 A  377  THR GLY CYS ALA ILE ASP ILE SER ARG GLN GLU LEU ARG          
SEQRES   4 A  377  CYS GLY SER GLY VAL PHE ILE HIS ASN ASP VAL GLU ALA          
SEQRES   5 A  377  TRP MET ASP ARG TYR LYS TYR TYR PRO GLU THR PRO GLN          
SEQRES   6 A  377  GLY LEU ALA LYS ILE ILE GLN LYS ALA HIS LYS GLU GLY          
SEQRES   7 A  377  VAL CYS GLY LEU ARG SER VAL SER ARG LEU GLU HIS GLN          
SEQRES   8 A  377  MET TRP GLU ALA VAL LYS ASP GLU LEU ASN THR LEU LEU          
SEQRES   9 A  377  LYS GLU ASN GLY VAL ASP LEU SER VAL VAL VAL GLU LYS          
SEQRES  10 A  377  GLN GLU GLY MET TYR LYS SER ALA PRO LYS ARG LEU THR          
SEQRES  11 A  377  ALA THR THR GLU LYS LEU GLU ILE GLY TRP LYS ALA TRP          
SEQRES  12 A  377  GLY LYS SER ILE LEU PHE ALA PRO GLU LEU ALA ASN ASN          
SEQRES  13 A  377  THR PHE VAL VAL ASP GLY PRO GLU THR LYS GLU CYS PRO          
SEQRES  14 A  377  THR GLN ASN ARG ALA TRP ASN SER LEU GLU VAL GLU ASP          
SEQRES  15 A  377  PHE GLY PHE GLY LEU THR SER THR ARG MET PHE LEU LYS          
SEQRES  16 A  377  VAL ARG GLU SER ASN THR THR GLU CYS ASP SER LYS ILE          
SEQRES  17 A  377  ILE GLY THR ALA VAL LYS ASN ASN LEU ALA ILE HIS SER          
SEQRES  18 A  377  ASP LEU SER TYR TRP ILE GLU SER ARG LEU ASN ASP THR          
SEQRES  19 A  377  TRP LYS LEU GLU ARG ALA VAL LEU GLY GLU VAL LYS SER          
SEQRES  20 A  377  CYS THR TRP PRO GLU THR HIS THR LEU TRP GLY ASP GLY          
SEQRES  21 A  377  ILE LEU GLU SER ASP LEU ILE ILE PRO VAL THR LEU ALA          
SEQRES  22 A  377  GLY PRO ARG SER ASN HIS ASN ARG ARG PRO GLY TYR LYS          
SEQRES  23 A  377  THR GLN ASN GLN GLY PRO TRP ASP GLU GLY ARG VAL GLU          
SEQRES  24 A  377  ILE ASP PHE ASP TYR CYS PRO GLY THR THR VAL THR LEU          
SEQRES  25 A  377  SER GLU SER CYS GLY HIS ARG GLY PRO ALA THR ARG THR          
SEQRES  26 A  377  THR THR GLU SER GLY LYS LEU ILE THR ASP TRP CYS CYS          
SEQRES  27 A  377  ARG SER CYS THR LEU PRO PRO LEU ARG TYR GLN THR ASP          
SEQRES  28 A  377  SER GLY CYS TRP TYR GLY MET GLU ILE ARG PRO GLN ARG          
SEQRES  29 A  377  HIS ASP GLU LYS THR LEU VAL GLN SER GLN VAL ASN ALA          
SEQRES   1 B  377  ALA GLU HIS HIS HIS HIS HIS HIS SER SER GLY VAL ASP          
SEQRES   2 B  377  LEU GLY THR GLU ASN LEU TYR PHE GLN SER ASN ALA ASP          
SEQRES   3 B  377  THR GLY CYS ALA ILE ASP ILE SER ARG GLN GLU LEU ARG          
SEQRES   4 B  377  CYS GLY SER GLY VAL PHE ILE HIS ASN ASP VAL GLU ALA          
SEQRES   5 B  377  TRP MET ASP ARG TYR LYS TYR TYR PRO GLU THR PRO GLN          
SEQRES   6 B  377  GLY LEU ALA LYS ILE ILE GLN LYS ALA HIS LYS GLU GLY          
SEQRES   7 B  377  VAL CYS GLY LEU ARG SER VAL SER ARG LEU GLU HIS GLN          
SEQRES   8 B  377  MET TRP GLU ALA VAL LYS ASP GLU LEU ASN THR LEU LEU          
SEQRES   9 B  377  LYS GLU ASN GLY VAL ASP LEU SER VAL VAL VAL GLU LYS          
SEQRES  10 B  377  GLN GLU GLY MET TYR LYS SER ALA PRO LYS ARG LEU THR          
SEQRES  11 B  377  ALA THR THR GLU LYS LEU GLU ILE GLY TRP LYS ALA TRP          
SEQRES  12 B  377  GLY LYS SER ILE LEU PHE ALA PRO GLU LEU ALA ASN ASN          
SEQRES  13 B  377  THR PHE VAL VAL ASP GLY PRO GLU THR LYS GLU CYS PRO          
SEQRES  14 B  377  THR GLN ASN ARG ALA TRP ASN SER LEU GLU VAL GLU ASP          
SEQRES  15 B  377  PHE GLY PHE GLY LEU THR SER THR ARG MET PHE LEU LYS          
SEQRES  16 B  377  VAL ARG GLU SER ASN THR THR GLU CYS ASP SER LYS ILE          
SEQRES  17 B  377  ILE GLY THR ALA VAL LYS ASN ASN LEU ALA ILE HIS SER          
SEQRES  18 B  377  ASP LEU SER TYR TRP ILE GLU SER ARG LEU ASN ASP THR          
SEQRES  19 B  377  TRP LYS LEU GLU ARG ALA VAL LEU GLY GLU VAL LYS SER          
SEQRES  20 B  377  CYS THR TRP PRO GLU THR HIS THR LEU TRP GLY ASP GLY          
SEQRES  21 B  377  ILE LEU GLU SER ASP LEU ILE ILE PRO VAL THR LEU ALA          
SEQRES  22 B  377  GLY PRO ARG SER ASN HIS ASN ARG ARG PRO GLY TYR LYS          
SEQRES  23 B  377  THR GLN ASN GLN GLY PRO TRP ASP GLU GLY ARG VAL GLU          
SEQRES  24 B  377  ILE ASP PHE ASP TYR CYS PRO GLY THR THR VAL THR LEU          
SEQRES  25 B  377  SER GLU SER CYS GLY HIS ARG GLY PRO ALA THR ARG THR          
SEQRES  26 B  377  THR THR GLU SER GLY LYS LEU ILE THR ASP TRP CYS CYS          
SEQRES  27 B  377  ARG SER CYS THR LEU PRO PRO LEU ARG TYR GLN THR ASP          
SEQRES  28 B  377  SER GLY CYS TRP TYR GLY MET GLU ILE ARG PRO GLN ARG          
SEQRES  29 B  377  HIS ASP GLU LYS THR LEU VAL GLN SER GLN VAL ASN ALA          
SEQRES   1 C  377  ALA GLU HIS HIS HIS HIS HIS HIS SER SER GLY VAL ASP          
SEQRES   2 C  377  LEU GLY THR GLU ASN LEU TYR PHE GLN SER ASN ALA ASP          
SEQRES   3 C  377  THR GLY CYS ALA ILE ASP ILE SER ARG GLN GLU LEU ARG          
SEQRES   4 C  377  CYS GLY SER GLY VAL PHE ILE HIS ASN ASP VAL GLU ALA          
SEQRES   5 C  377  TRP MET ASP ARG TYR LYS TYR TYR PRO GLU THR PRO GLN          
SEQRES   6 C  377  GLY LEU ALA LYS ILE ILE GLN LYS ALA HIS LYS GLU GLY          
SEQRES   7 C  377  VAL CYS GLY LEU ARG SER VAL SER ARG LEU GLU HIS GLN          
SEQRES   8 C  377  MET TRP GLU ALA VAL LYS ASP GLU LEU ASN THR LEU LEU          
SEQRES   9 C  377  LYS GLU ASN GLY VAL ASP LEU SER VAL VAL VAL GLU LYS          
SEQRES  10 C  377  GLN GLU GLY MET TYR LYS SER ALA PRO LYS ARG LEU THR          
SEQRES  11 C  377  ALA THR THR GLU LYS LEU GLU ILE GLY TRP LYS ALA TRP          
SEQRES  12 C  377  GLY LYS SER ILE LEU PHE ALA PRO GLU LEU ALA ASN ASN          
SEQRES  13 C  377  THR PHE VAL VAL ASP GLY PRO GLU THR LYS GLU CYS PRO          
SEQRES  14 C  377  THR GLN ASN ARG ALA TRP ASN SER LEU GLU VAL GLU ASP          
SEQRES  15 C  377  PHE GLY PHE GLY LEU THR SER THR ARG MET PHE LEU LYS          
SEQRES  16 C  377  VAL ARG GLU SER ASN THR THR GLU CYS ASP SER LYS ILE          
SEQRES  17 C  377  ILE GLY THR ALA VAL LYS ASN ASN LEU ALA ILE HIS SER          
SEQRES  18 C  377  ASP LEU SER TYR TRP ILE GLU SER ARG LEU ASN ASP THR          
SEQRES  19 C  377  TRP LYS LEU GLU ARG ALA VAL LEU GLY GLU VAL LYS SER          
SEQRES  20 C  377  CYS THR TRP PRO GLU THR HIS THR LEU TRP GLY ASP GLY          
SEQRES  21 C  377  ILE LEU GLU SER ASP LEU ILE ILE PRO VAL THR LEU ALA          
SEQRES  22 C  377  GLY PRO ARG SER ASN HIS ASN ARG ARG PRO GLY TYR LYS          
SEQRES  23 C  377  THR GLN ASN GLN GLY PRO TRP ASP GLU GLY ARG VAL GLU          
SEQRES  24 C  377  ILE ASP PHE ASP TYR CYS PRO GLY THR THR VAL THR LEU          
SEQRES  25 C  377  SER GLU SER CYS GLY HIS ARG GLY PRO ALA THR ARG THR          
SEQRES  26 C  377  THR THR GLU SER GLY LYS LEU ILE THR ASP TRP CYS CYS          
SEQRES  27 C  377  ARG SER CYS THR LEU PRO PRO LEU ARG TYR GLN THR ASP          
SEQRES  28 C  377  SER GLY CYS TRP TYR GLY MET GLU ILE ARG PRO GLN ARG          
SEQRES  29 C  377  HIS ASP GLU LYS THR LEU VAL GLN SER GLN VAL ASN ALA          
SEQRES   1 D  377  ALA GLU HIS HIS HIS HIS HIS HIS SER SER GLY VAL ASP          
SEQRES   2 D  377  LEU GLY THR GLU ASN LEU TYR PHE GLN SER ASN ALA ASP          
SEQRES   3 D  377  THR GLY CYS ALA ILE ASP ILE SER ARG GLN GLU LEU ARG          
SEQRES   4 D  377  CYS GLY SER GLY VAL PHE ILE HIS ASN ASP VAL GLU ALA          
SEQRES   5 D  377  TRP MET ASP ARG TYR LYS TYR TYR PRO GLU THR PRO GLN          
SEQRES   6 D  377  GLY LEU ALA LYS ILE ILE GLN LYS ALA HIS LYS GLU GLY          
SEQRES   7 D  377  VAL CYS GLY LEU ARG SER VAL SER ARG LEU GLU HIS GLN          
SEQRES   8 D  377  MET TRP GLU ALA VAL LYS ASP GLU LEU ASN THR LEU LEU          
SEQRES   9 D  377  LYS GLU ASN GLY VAL ASP LEU SER VAL VAL VAL GLU LYS          
SEQRES  10 D  377  GLN GLU GLY MET TYR LYS SER ALA PRO LYS ARG LEU THR          
SEQRES  11 D  377  ALA THR THR GLU LYS LEU GLU ILE GLY TRP LYS ALA TRP          
SEQRES  12 D  377  GLY LYS SER ILE LEU PHE ALA PRO GLU LEU ALA ASN ASN          
SEQRES  13 D  377  THR PHE VAL VAL ASP GLY PRO GLU THR LYS GLU CYS PRO          
SEQRES  14 D  377  THR GLN ASN ARG ALA TRP ASN SER LEU GLU VAL GLU ASP          
SEQRES  15 D  377  PHE GLY PHE GLY LEU THR SER THR ARG MET PHE LEU LYS          
SEQRES  16 D  377  VAL ARG GLU SER ASN THR THR GLU CYS ASP SER LYS ILE          
SEQRES  17 D  377  ILE GLY THR ALA VAL LYS ASN ASN LEU ALA ILE HIS SER          
SEQRES  18 D  377  ASP LEU SER TYR TRP ILE GLU SER ARG LEU ASN ASP THR          
SEQRES  19 D  377  TRP LYS LEU GLU ARG ALA VAL LEU GLY GLU VAL LYS SER          
SEQRES  20 D  377  CYS THR TRP PRO GLU THR HIS THR LEU TRP GLY ASP GLY          
SEQRES  21 D  377  ILE LEU GLU SER ASP LEU ILE ILE PRO VAL THR LEU ALA          
SEQRES  22 D  377  GLY PRO ARG SER ASN HIS ASN ARG ARG PRO GLY TYR LYS          
SEQRES  23 D  377  THR GLN ASN GLN GLY PRO TRP ASP GLU GLY ARG VAL GLU          
SEQRES  24 D  377  ILE ASP PHE ASP TYR CYS PRO GLY THR THR VAL THR LEU          
SEQRES  25 D  377  SER GLU SER CYS GLY HIS ARG GLY PRO ALA THR ARG THR          
SEQRES  26 D  377  THR THR GLU SER GLY LYS LEU ILE THR ASP TRP CYS CYS          
SEQRES  27 D  377  ARG SER CYS THR LEU PRO PRO LEU ARG TYR GLN THR ASP          
SEQRES  28 D  377  SER GLY CYS TRP TYR GLY MET GLU ILE ARG PRO GLN ARG          
SEQRES  29 D  377  HIS ASP GLU LYS THR LEU VAL GLN SER GLN VAL ASN ALA          
SEQRES   1 E  377  ALA GLU HIS HIS HIS HIS HIS HIS SER SER GLY VAL ASP          
SEQRES   2 E  377  LEU GLY THR GLU ASN LEU TYR PHE GLN SER ASN ALA ASP          
SEQRES   3 E  377  THR GLY CYS ALA ILE ASP ILE SER ARG GLN GLU LEU ARG          
SEQRES   4 E  377  CYS GLY SER GLY VAL PHE ILE HIS ASN ASP VAL GLU ALA          
SEQRES   5 E  377  TRP MET ASP ARG TYR LYS TYR TYR PRO GLU THR PRO GLN          
SEQRES   6 E  377  GLY LEU ALA LYS ILE ILE GLN LYS ALA HIS LYS GLU GLY          
SEQRES   7 E  377  VAL CYS GLY LEU ARG SER VAL SER ARG LEU GLU HIS GLN          
SEQRES   8 E  377  MET TRP GLU ALA VAL LYS ASP GLU LEU ASN THR LEU LEU          
SEQRES   9 E  377  LYS GLU ASN GLY VAL ASP LEU SER VAL VAL VAL GLU LYS          
SEQRES  10 E  377  GLN GLU GLY MET TYR LYS SER ALA PRO LYS ARG LEU THR          
SEQRES  11 E  377  ALA THR THR GLU LYS LEU GLU ILE GLY TRP LYS ALA TRP          
SEQRES  12 E  377  GLY LYS SER ILE LEU PHE ALA PRO GLU LEU ALA ASN ASN          
SEQRES  13 E  377  THR PHE VAL VAL ASP GLY PRO GLU THR LYS GLU CYS PRO          
SEQRES  14 E  377  THR GLN ASN ARG ALA TRP ASN SER LEU GLU VAL GLU ASP          
SEQRES  15 E  377  PHE GLY PHE GLY LEU THR SER THR ARG MET PHE LEU LYS          
SEQRES  16 E  377  VAL ARG GLU SER ASN THR THR GLU CYS ASP SER LYS ILE          
SEQRES  17 E  377  ILE GLY THR ALA VAL LYS ASN ASN LEU ALA ILE HIS SER          
SEQRES  18 E  377  ASP LEU SER TYR TRP ILE GLU SER ARG LEU ASN ASP THR          
SEQRES  19 E  377  TRP LYS LEU GLU ARG ALA VAL LEU GLY GLU VAL LYS SER          
SEQRES  20 E  377  CYS THR TRP PRO GLU THR HIS THR LEU TRP GLY ASP GLY          
SEQRES  21 E  377  ILE LEU GLU SER ASP LEU ILE ILE PRO VAL THR LEU ALA          
SEQRES  22 E  377  GLY PRO ARG SER ASN HIS ASN ARG ARG PRO GLY TYR LYS          
SEQRES  23 E  377  THR GLN ASN GLN GLY PRO TRP ASP GLU GLY ARG VAL GLU          
SEQRES  24 E  377  ILE ASP PHE ASP TYR CYS PRO GLY THR THR VAL THR LEU          
SEQRES  25 E  377  SER GLU SER CYS GLY HIS ARG GLY PRO ALA THR ARG THR          
SEQRES  26 E  377  THR THR GLU SER GLY LYS LEU ILE THR ASP TRP CYS CYS          
SEQRES  27 E  377  ARG SER CYS THR LEU PRO PRO LEU ARG TYR GLN THR ASP          
SEQRES  28 E  377  SER GLY CYS TRP TYR GLY MET GLU ILE ARG PRO GLN ARG          
SEQRES  29 E  377  HIS ASP GLU LYS THR LEU VAL GLN SER GLN VAL ASN ALA          
SEQRES   1 F  377  ALA GLU HIS HIS HIS HIS HIS HIS SER SER GLY VAL ASP          
SEQRES   2 F  377  LEU GLY THR GLU ASN LEU TYR PHE GLN SER ASN ALA ASP          
SEQRES   3 F  377  THR GLY CYS ALA ILE ASP ILE SER ARG GLN GLU LEU ARG          
SEQRES   4 F  377  CYS GLY SER GLY VAL PHE ILE HIS ASN ASP VAL GLU ALA          
SEQRES   5 F  377  TRP MET ASP ARG TYR LYS TYR TYR PRO GLU THR PRO GLN          
SEQRES   6 F  377  GLY LEU ALA LYS ILE ILE GLN LYS ALA HIS LYS GLU GLY          
SEQRES   7 F  377  VAL CYS GLY LEU ARG SER VAL SER ARG LEU GLU HIS GLN          
SEQRES   8 F  377  MET TRP GLU ALA VAL LYS ASP GLU LEU ASN THR LEU LEU          
SEQRES   9 F  377  LYS GLU ASN GLY VAL ASP LEU SER VAL VAL VAL GLU LYS          
SEQRES  10 F  377  GLN GLU GLY MET TYR LYS SER ALA PRO LYS ARG LEU THR          
SEQRES  11 F  377  ALA THR THR GLU LYS LEU GLU ILE GLY TRP LYS ALA TRP          
SEQRES  12 F  377  GLY LYS SER ILE LEU PHE ALA PRO GLU LEU ALA ASN ASN          
SEQRES  13 F  377  THR PHE VAL VAL ASP GLY PRO GLU THR LYS GLU CYS PRO          
SEQRES  14 F  377  THR GLN ASN ARG ALA TRP ASN SER LEU GLU VAL GLU ASP          
SEQRES  15 F  377  PHE GLY PHE GLY LEU THR SER THR ARG MET PHE LEU LYS          
SEQRES  16 F  377  VAL ARG GLU SER ASN THR THR GLU CYS ASP SER LYS ILE          
SEQRES  17 F  377  ILE GLY THR ALA VAL LYS ASN ASN LEU ALA ILE HIS SER          
SEQRES  18 F  377  ASP LEU SER TYR TRP ILE GLU SER ARG LEU ASN ASP THR          
SEQRES  19 F  377  TRP LYS LEU GLU ARG ALA VAL LEU GLY GLU VAL LYS SER          
SEQRES  20 F  377  CYS THR TRP PRO GLU THR HIS THR LEU TRP GLY ASP GLY          
SEQRES  21 F  377  ILE LEU GLU SER ASP LEU ILE ILE PRO VAL THR LEU ALA          
SEQRES  22 F  377  GLY PRO ARG SER ASN HIS ASN ARG ARG PRO GLY TYR LYS          
SEQRES  23 F  377  THR GLN ASN GLN GLY PRO TRP ASP GLU GLY ARG VAL GLU          
SEQRES  24 F  377  ILE ASP PHE ASP TYR CYS PRO GLY THR THR VAL THR LEU          
SEQRES  25 F  377  SER GLU SER CYS GLY HIS ARG GLY PRO ALA THR ARG THR          
SEQRES  26 F  377  THR THR GLU SER GLY LYS LEU ILE THR ASP TRP CYS CYS          
SEQRES  27 F  377  ARG SER CYS THR LEU PRO PRO LEU ARG TYR GLN THR ASP          
SEQRES  28 F  377  SER GLY CYS TRP TYR GLY MET GLU ILE ARG PRO GLN ARG          
SEQRES  29 F  377  HIS ASP GLU LYS THR LEU VAL GLN SER GLN VAL ASN ALA          
MODRES 4O6C ASN C  130  ASN  GLYCOSYLATION SITE                                 
MODRES 4O6C ASN F  130  ASN  GLYCOSYLATION SITE                                 
MODRES 4O6C ASN B  130  ASN  GLYCOSYLATION SITE                                 
MODRES 4O6C ASN D  130  ASN  GLYCOSYLATION SITE                                 
MODRES 4O6C ASN A  130  ASN  GLYCOSYLATION SITE                                 
MODRES 4O6C ASN E  130  ASN  GLYCOSYLATION SITE                                 
HET    NAG  A 401      14                                                       
HET    SO4  A 402       5                                                       
HET    NAG  B 401      14                                                       
HET    NAG  C 401      14                                                       
HET    SO4  C 402       5                                                       
HET    NAG  D 401      14                                                       
HET    NAG  E 401      14                                                       
HET    NAG  F 401      14                                                       
HET    SO4  F 402       5                                                       
HETNAM     NAG N-ACETYL-D-GLUCOSAMINE                                           
HETNAM     SO4 SULFATE ION                                                      
FORMUL   7  NAG    6(C8 H15 N O6)                                               
FORMUL   8  SO4    3(O4 S 2-)                                                   
HELIX    1   1 THR A   38  GLU A   52  1                                  15    
HELIX    2   2 SER A   61  ASN A   82  1                                  22    
HELIX    3   3 PRO A  144  GLN A  146  5                                   3    
HELIX    4   4 PRO A  226  THR A  230  5                                   5    
HELIX    5   5 LEU A  237  LEU A  241  5                                   5    
HELIX    6   6 PRO A  244  ALA A  248  5                                   5    
HELIX    7   7 PRO A  267  GLY A  271  5                                   5    
HELIX    8   8 THR B   38  GLU B   52  1                                  15    
HELIX    9   9 SER B   61  ASN B   82  1                                  22    
HELIX   10  10 PRO B  144  GLN B  146  5                                   3    
HELIX   11  11 PRO B  226  THR B  230  5                                   5    
HELIX   12  12 LEU B  237  LEU B  241  5                                   5    
HELIX   13  13 PRO B  244  ALA B  248  5                                   5    
HELIX   14  14 PRO B  267  GLY B  271  5                                   5    
HELIX   15  15 THR C   38  GLY C   53  1                                  16    
HELIX   16  16 SER C   61  ASN C   82  1                                  22    
HELIX   17  17 PRO C  144  GLN C  146  5                                   3    
HELIX   18  18 PRO C  226  THR C  230  5                                   5    
HELIX   19  19 LEU C  237  LEU C  241  5                                   5    
HELIX   20  20 PRO C  244  ALA C  248  5                                   5    
HELIX   21  21 PRO C  267  GLY C  271  5                                   5    
HELIX   22  22 THR D   38  GLU D   52  1                                  15    
HELIX   23  23 SER D   61  GLY D   83  1                                  23    
HELIX   24  24 PRO D  144  GLN D  146  5                                   3    
HELIX   25  25 PRO D  226  THR D  230  5                                   5    
HELIX   26  26 LEU D  237  LEU D  241  5                                   5    
HELIX   27  27 PRO D  244  ALA D  248  5                                   5    
HELIX   28  28 PRO D  267  GLY D  271  5                                   5    
HELIX   29  29 THR E   38  GLY E   53  1                                  16    
HELIX   30  30 SER E   61  ASN E   82  1                                  22    
HELIX   31  31 PRO E  144  GLN E  146  5                                   3    
HELIX   32  32 PRO E  226  THR E  230  5                                   5    
HELIX   33  33 LEU E  237  LEU E  241  5                                   5    
HELIX   34  34 PRO E  244  ALA E  248  5                                   5    
HELIX   35  35 PRO E  267  GLY E  271  5                                   5    
HELIX   36  36 THR F   38  GLU F   52  1                                  15    
HELIX   37  37 SER F   61  GLY F   83  1                                  23    
HELIX   38  38 PRO F  144  GLN F  146  5                                   3    
HELIX   39  39 PRO F  226  THR F  230  5                                   5    
HELIX   40  40 LEU F  237  LEU F  241  5                                   5    
HELIX   41  41 PRO F  244  ALA F  248  5                                   5    
HELIX   42  42 PRO F  267  GLY F  271  5                                   5    
SHEET    1   A 5 ASP A   1  ASP A   7  0                                        
SHEET    2   A 5 GLU A  12  HIS A  22 -1  O  GLY A  16   N  GLY A   3           
SHEET    3   A 5 GLU B  12  HIS B  22 -1  O  ILE B  21   N  VAL A  19           
SHEET    4   A 5 ASP B   1  ASP B   7 -1  N  ASP B   1   O  GLY B  18           
SHEET    5   A 5 ASP A   1  ASP A   7 -1  N  ILE A   6   O  THR B   2           
SHEET    1   B 3 TYR A  32  PRO A  36  0                                        
SHEET    2   B 3 THR A 165  VAL A 171  1  O  MET A 167   N  LYS A  33           
SHEET    3   B 3 LEU A 153  GLY A 159 -1  N  GLU A 156   O  PHE A 168           
SHEET    1   C 4 LEU A  86  VAL A  90  0                                        
SHEET    2   C 4 ASN A 131  VAL A 135  1  O  VAL A 135   N  VAL A  89           
SHEET    3   C 4 GLY A  56  LEU A  57  1  N  LEU A  57   O  VAL A 134           
SHEET    4   C 4 ARG A 148  ALA A 149  1  O  ALA A 149   N  GLY A  56           
SHEET    1   D14 GLY A 328  TYR A 331  0                                        
SHEET    2   D14 LEU A 321  THR A 325 -1  N  TYR A 323   O  TRP A 330           
SHEET    3   D14 VAL A 273  PHE A 277 -1  N  ASP A 276   O  ARG A 322           
SHEET    4   D14 TRP A 210  LEU A 217 -1  N  ALA A 215   O  ILE A 275           
SHEET    5   D14 TYR A 200  LEU A 206 -1  N  GLU A 203   O  ARG A 214           
SHEET    6   D14 LEU A 192  SER A 196 -1  N  ALA A 193   O  SER A 204           
SHEET    7   D14 GLY A 185  LYS A 189 -1  N  GLY A 185   O  SER A 196           
SHEET    8   D14 GLY B 185  LYS B 189 -1  O  VAL B 188   N  THR A 186           
SHEET    9   D14 LEU B 192  SER B 196 -1  O  ILE B 194   N  ALA B 187           
SHEET   10   D14 TYR B 200  LEU B 206 -1  O  SER B 204   N  ALA B 193           
SHEET   11   D14 TRP B 210  LEU B 217 -1  O  ARG B 214   N  GLU B 203           
SHEET   12   D14 VAL B 273  PHE B 277 -1  O  ILE B 275   N  ALA B 215           
SHEET   13   D14 LEU B 321  THR B 325 -1  O  ARG B 322   N  ASP B 276           
SHEET   14   D14 GLY B 328  TYR B 331 -1  O  TRP B 330   N  TYR B 323           
SHEET    1   E 3 THR A 284  LEU A 287  0                                        
SHEET    2   E 3 ASP A 310  CYS A 313  1  O  TRP A 311   N  THR A 284           
SHEET    3   E 3 ARG A 336  PRO A 337 -1  O  ARG A 336   N  CYS A 312           
SHEET    1   F 3 TYR B  32  PRO B  36  0                                        
SHEET    2   F 3 THR B 165  VAL B 171  1  O  MET B 167   N  LYS B  33           
SHEET    3   F 3 LEU B 153  GLY B 159 -1  N  GLU B 156   O  PHE B 168           
SHEET    1   G 4 LEU B  86  VAL B  90  0                                        
SHEET    2   G 4 ASN B 131  VAL B 135  1  O  VAL B 135   N  VAL B  89           
SHEET    3   G 4 GLY B  56  LEU B  57  1  N  LEU B  57   O  VAL B 134           
SHEET    4   G 4 ARG B 148  ALA B 149  1  O  ALA B 149   N  GLY B  56           
SHEET    1   H 3 THR B 284  LEU B 287  0                                        
SHEET    2   H 3 ASP B 310  CYS B 313  1  O  TRP B 311   N  THR B 284           
SHEET    3   H 3 ILE B 335  PRO B 337 -1  O  ARG B 336   N  CYS B 312           
SHEET    1   I 5 ASP C   1  ASP C   7  0                                        
SHEET    2   I 5 GLU C  12  HIS C  22 -1  O  GLY C  18   N  ASP C   1           
SHEET    3   I 5 GLU D  12  HIS D  22 -1  O  ILE D  21   N  VAL C  19           
SHEET    4   I 5 ASP D   1  ASP D   7 -1  N  ASP D   1   O  GLY D  18           
SHEET    5   I 5 ASP C   1  ASP C   7 -1  N  ILE C   6   O  THR D   2           
SHEET    1   J 3 TYR C  32  PRO C  36  0                                        
SHEET    2   J 3 THR C 165  VAL C 171  1  O  MET C 167   N  LYS C  33           
SHEET    3   J 3 LEU C 153  GLY C 159 -1  N  GLY C 159   O  ARG C 166           
SHEET    1   K 4 LEU C  86  VAL C  90  0                                        
SHEET    2   K 4 ASN C 131  VAL C 135  1  O  PHE C 133   N  VAL C  89           
SHEET    3   K 4 GLY C  56  ARG C  58  1  N  LEU C  57   O  VAL C 134           
SHEET    4   K 4 ARG C 148  TRP C 150  1  O  ALA C 149   N  ARG C  58           
SHEET    1   L14 GLY C 328  TYR C 331  0                                        
SHEET    2   L14 LEU C 321  THR C 325 -1  N  TYR C 323   O  TRP C 330           
SHEET    3   L14 VAL C 273  PHE C 277 -1  N  ASP C 276   O  ARG C 322           
SHEET    4   L14 TRP C 210  LEU C 217 -1  N  ALA C 215   O  ILE C 275           
SHEET    5   L14 TYR C 200  LEU C 206 -1  N  GLU C 203   O  ARG C 214           
SHEET    6   L14 LEU C 192  SER C 196 -1  N  HIS C 195   O  ILE C 202           
SHEET    7   L14 GLY C 185  LYS C 189 -1  N  ALA C 187   O  ILE C 194           
SHEET    8   L14 GLY D 185  LYS D 189 -1  O  VAL D 188   N  THR C 186           
SHEET    9   L14 LEU D 192  SER D 196 -1  O  SER D 196   N  GLY D 185           
SHEET   10   L14 TYR D 200  LEU D 206 -1  O  ILE D 202   N  HIS D 195           
SHEET   11   L14 TRP D 210  LEU D 217 -1  O  ARG D 214   N  GLU D 203           
SHEET   12   L14 VAL D 273  PHE D 277 -1  O  ILE D 275   N  ALA D 215           
SHEET   13   L14 LEU D 321  THR D 325 -1  O  ARG D 322   N  ASP D 276           
SHEET   14   L14 GLY D 328  TYR D 331 -1  O  TRP D 330   N  TYR D 323           
SHEET    1   M 3 THR C 284  LEU C 287  0                                        
SHEET    2   M 3 ASP C 310  CYS C 313  1  O  TRP C 311   N  THR C 284           
SHEET    3   M 3 ILE C 335  PRO C 337 -1  O  ARG C 336   N  CYS C 312           
SHEET    1   N 3 TYR D  32  PRO D  36  0                                        
SHEET    2   N 3 THR D 165  VAL D 171  1  O  MET D 167   N  LYS D  33           
SHEET    3   N 3 LEU D 153  GLY D 159 -1  N  GLU D 156   O  PHE D 168           
SHEET    1   O 4 LEU D  86  VAL D  90  0                                        
SHEET    2   O 4 ASN D 131  VAL D 135  1  O  PHE D 133   N  VAL D  89           
SHEET    3   O 4 GLY D  56  LEU D  57  1  N  LEU D  57   O  VAL D 134           
SHEET    4   O 4 ARG D 148  ALA D 149  1  O  ALA D 149   N  GLY D  56           
SHEET    1   P 3 THR D 284  LEU D 287  0                                        
SHEET    2   P 3 ASP D 310  CYS D 313  1  O  TRP D 311   N  THR D 284           
SHEET    3   P 3 ILE D 335  PRO D 337 -1  O  ARG D 336   N  CYS D 312           
SHEET    1   Q 5 ASP E   1  ASP E   7  0                                        
SHEET    2   Q 5 GLU E  12  HIS E  22 -1  O  GLY E  18   N  ASP E   1           
SHEET    3   Q 5 GLU F  12  HIS F  22 -1  O  VAL F  19   N  ILE E  21           
SHEET    4   Q 5 ASP F   1  ASP F   7 -1  N  ASP F   1   O  GLY F  18           
SHEET    5   Q 5 ASP E   1  ASP E   7 -1  N  THR E   2   O  ILE F   6           
SHEET    1   R 3 TYR E  32  PRO E  36  0                                        
SHEET    2   R 3 THR E 165  VAL E 171  1  O  MET E 167   N  LYS E  33           
SHEET    3   R 3 LEU E 153  GLY E 159 -1  N  GLU E 156   O  PHE E 168           
SHEET    1   S 4 LEU E  86  VAL E  90  0                                        
SHEET    2   S 4 ASN E 131  VAL E 135  1  O  VAL E 135   N  VAL E  89           
SHEET    3   S 4 GLY E  56  LEU E  57  1  N  LEU E  57   O  VAL E 134           
SHEET    4   S 4 ARG E 148  ALA E 149  1  O  ALA E 149   N  GLY E  56           
SHEET    1   T14 GLY E 328  TYR E 331  0                                        
SHEET    2   T14 LEU E 321  THR E 325 -1  N  TYR E 323   O  TRP E 330           
SHEET    3   T14 VAL E 273  PHE E 277 -1  N  ASP E 276   O  ARG E 322           
SHEET    4   T14 TRP E 210  LEU E 217 -1  N  ALA E 215   O  ILE E 275           
SHEET    5   T14 TYR E 200  LEU E 206 -1  N  GLU E 203   O  ARG E 214           
SHEET    6   T14 LEU E 192  SER E 196 -1  N  HIS E 195   O  ILE E 202           
SHEET    7   T14 GLY E 185  LYS E 189 -1  N  ALA E 187   O  ILE E 194           
SHEET    8   T14 GLY F 185  LYS F 189 -1  O  THR F 186   N  VAL E 188           
SHEET    9   T14 LEU F 192  SER F 196 -1  O  ILE F 194   N  ALA F 187           
SHEET   10   T14 TYR F 200  LEU F 206 -1  O  ILE F 202   N  HIS F 195           
SHEET   11   T14 TRP F 210  LEU F 217 -1  O  ARG F 214   N  GLU F 203           
SHEET   12   T14 VAL F 273  PHE F 277 -1  O  ILE F 275   N  ALA F 215           
SHEET   13   T14 LEU F 321  THR F 325 -1  O  ARG F 322   N  ASP F 276           
SHEET   14   T14 GLY F 328  TYR F 331 -1  O  TRP F 330   N  TYR F 323           
SHEET    1   U 3 THR E 284  LEU E 287  0                                        
SHEET    2   U 3 ASP E 310  CYS E 313  1  O  TRP E 311   N  THR E 284           
SHEET    3   U 3 ILE E 335  PRO E 337 -1  O  ARG E 336   N  CYS E 312           
SHEET    1   V 3 TYR F  32  PRO F  36  0                                        
SHEET    2   V 3 THR F 165  VAL F 171  1  O  MET F 167   N  LYS F  33           
SHEET    3   V 3 LEU F 153  GLY F 159 -1  N  GLY F 159   O  ARG F 166           
SHEET    1   W 4 LEU F  86  VAL F  90  0                                        
SHEET    2   W 4 ASN F 131  VAL F 135  1  O  PHE F 133   N  VAL F  89           
SHEET    3   W 4 GLY F  56  LEU F  57  1  N  LEU F  57   O  VAL F 134           
SHEET    4   W 4 ARG F 148  ALA F 149  1  O  ALA F 149   N  GLY F  56           
SHEET    1   X 3 THR F 284  LEU F 287  0                                        
SHEET    2   X 3 ASP F 310  CYS F 313  1  O  TRP F 311   N  THR F 284           
SHEET    3   X 3 ARG F 336  PRO F 337 -1  O  ARG F 336   N  CYS F 312           
SSBOND   1 CYS A    4    CYS A   15                          1555   1555  2.04  
SSBOND   2 CYS A   55    CYS A  143                          1555   1555  2.03  
SSBOND   3 CYS A  179    CYS A  223                          1555   1555  2.03  
SSBOND   4 CYS A  280    CYS A  329                          1555   1555  2.04  
SSBOND   5 CYS A  291    CYS A  312                          1555   1555  2.04  
SSBOND   6 CYS A  313    CYS A  316                          1555   1555  2.03  
SSBOND   7 CYS B    4    CYS B   15                          1555   1555  2.04  
SSBOND   8 CYS B   55    CYS B  143                          1555   1555  2.03  
SSBOND   9 CYS B  179    CYS B  223                          1555   1555  2.02  
SSBOND  10 CYS B  280    CYS B  329                          1555   1555  2.03  
SSBOND  11 CYS B  291    CYS B  312                          1555   1555  2.03  
SSBOND  12 CYS B  313    CYS B  316                          1555   1555  2.03  
SSBOND  13 CYS C    4    CYS C   15                          1555   1555  2.03  
SSBOND  14 CYS C   55    CYS C  143                          1555   1555  2.03  
SSBOND  15 CYS C  179    CYS C  223                          1555   1555  2.03  
SSBOND  16 CYS C  280    CYS C  329                          1555   1555  2.03  
SSBOND  17 CYS C  291    CYS C  312                          1555   1555  2.03  
SSBOND  18 CYS C  313    CYS C  316                          1555   1555  2.03  
SSBOND  19 CYS D    4    CYS D   15                          1555   1555  2.03  
SSBOND  20 CYS D   55    CYS D  143                          1555   1555  2.03  
SSBOND  21 CYS D  179    CYS D  223                          1555   1555  2.03  
SSBOND  22 CYS D  280    CYS D  329                          1555   1555  2.04  
SSBOND  23 CYS D  291    CYS D  312                          1555   1555  2.03  
SSBOND  24 CYS D  313    CYS D  316                          1555   1555  2.03  
SSBOND  25 CYS E    4    CYS E   15                          1555   1555  2.03  
SSBOND  26 CYS E   55    CYS E  143                          1555   1555  2.03  
SSBOND  27 CYS E  179    CYS E  223                          1555   1555  2.03  
SSBOND  28 CYS E  280    CYS E  329                          1555   1555  2.04  
SSBOND  29 CYS E  291    CYS E  312                          1555   1555  2.04  
SSBOND  30 CYS E  313    CYS E  316                          1555   1555  2.03  
SSBOND  31 CYS F    4    CYS F   15                          1555   1555  2.03  
SSBOND  32 CYS F   55    CYS F  143                          1555   1555  2.03  
SSBOND  33 CYS F  179    CYS F  223                          1555   1555  2.04  
SSBOND  34 CYS F  280    CYS F  329                          1555   1555  2.03  
SSBOND  35 CYS F  291    CYS F  312                          1555   1555  2.03  
SSBOND  36 CYS F  313    CYS F  316                          1555   1555  2.03  
LINK         ND2 ASN C 130                 C1  NAG C 401     1555   1555  1.44  
LINK         ND2 ASN F 130                 C1  NAG F 401     1555   1555  1.44  
LINK         ND2 ASN B 130                 C1  NAG B 401     1555   1555  1.44  
LINK         ND2 ASN D 130                 C1  NAG D 401     1555   1555  1.44  
LINK         ND2 ASN A 130                 C1  NAG A 401     1555   1555  1.44  
LINK         ND2 ASN E 130                 C1  NAG E 401     1555   1555  1.44  
CISPEP   1 LEU A  318    PRO A  319          0         1.32                     
CISPEP   2 LEU B  318    PRO B  319          0         0.92                     
CISPEP   3 LEU C  318    PRO C  319          0         1.16                     
CISPEP   4 LEU D  318    PRO D  319          0         1.13                     
CISPEP   5 LEU E  318    PRO E  319          0         0.67                     
CISPEP   6 LEU F  318    PRO F  319          0         1.15                     
SITE     1 AC1  2 ASP A  85  ASN A 130                                          
SITE     1 AC2  2 GLY A 235  GLY B 235                                          
SITE     1 AC3  2 ASP B  85  ASN B 130                                          
SITE     1 AC4  2 ASP C  85  ASN C 130                                          
SITE     1 AC5  4 ASP C 234  GLY C 235  ASP D 234  GLY D 235                    
SITE     1 AC6  2 ASP D  85  ASN D 130                                          
SITE     1 AC7  2 ASP E  85  ASN E 130                                          
SITE     1 AC8  2 ASP F  85  ASN F 130                                          
SITE     1 AC9  7 GLY E 233  ASP E 234  GLY E 235  GLY F 233                    
SITE     2 AC9  7 ASP F 234  GLY F 235  ILE F 236                               
CRYST1  186.885  186.885   81.765  90.00  90.00 120.00 P 3          18          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.005351  0.003089  0.000000        0.00000                         
SCALE2      0.000000  0.006179  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.012230        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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