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Database: PDB
Entry: 4Q7J
LinkDB: 4Q7J
Original site: 4Q7J 
HEADER    TRANSLATION/TRANSFERASE                 25-APR-14   4Q7J              
TITLE     COMPLEX STRUCTURE OF VIRAL RNA POLYMERASE                             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: ELONGATION FACTOR TS;                                      
COMPND   3 CHAIN: A, E;                                                         
COMPND   4 SYNONYM: EF-TS;                                                      
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: ELONGATION FACTOR TU 1;                                    
COMPND   8 CHAIN: B, F;                                                         
COMPND   9 SYNONYM: EF-TU;                                                      
COMPND  10 ENGINEERED: YES;                                                     
COMPND  11 MOL_ID: 3;                                                           
COMPND  12 MOLECULE: Q BETA REPLICASE;                                          
COMPND  13 CHAIN: C, G;                                                         
COMPND  14 ENGINEERED: YES;                                                     
COMPND  15 MOL_ID: 4;                                                           
COMPND  16 MOLECULE: 30S RIBOSOMAL PROTEIN S1;                                  
COMPND  17 CHAIN: D, H;                                                         
COMPND  18 FRAGMENT: UNP RESIDUES 1-273;                                        
COMPND  19 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;                               
SOURCE   3 ORGANISM_TAXID: 83333;                                               
SOURCE   4 STRAIN: K12;                                                         
SOURCE   5 GENE: TSF;                                                           
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;                               
SOURCE  10 ORGANISM_TAXID: 83333;                                               
SOURCE  11 STRAIN: K12;                                                         
SOURCE  12 GENE: TUFA;                                                          
SOURCE  13 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: ENTEROBACTERIA PHAGE QBETA;                     
SOURCE  17 ORGANISM_TAXID: 39803;                                               
SOURCE  18 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  19 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  20 MOL_ID: 4;                                                           
SOURCE  21 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;                               
SOURCE  22 ORGANISM_TAXID: 83333;                                               
SOURCE  23 STRAIN: K12;                                                         
SOURCE  24 GENE: RPSA;                                                          
SOURCE  25 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  26 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    RNA POLYMERASE, RNA BINDING MOTIF, RNA DEPENDENT RNA POLYMERIZATION,  
KEYWDS   2 TRANSLATION-TRANSFERASE COMPLEX                                      
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    D.TAKESHITA                                                           
REVDAT   1   27-AUG-14 4Q7J    0                                                
JRNL        AUTH   D.TAKESHITA,S.YAMASHITA,K.TOMITA                             
JRNL        TITL   MOLECULAR INSIGHTS INTO REPLICATION INITIATION BY Q BETA     
JRNL        TITL 2 REPLICASE USING RIBOSOMAL PROTEIN S1                         
JRNL        REF    NUCLEIC ACIDS RES.                         2014              
JRNL        REFN                   ESSN 1362-4962                               
JRNL        PMID   25122749                                                     
JRNL        DOI    10.1093/NAR/GKU745                                           
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.90 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.8.2_1309)                   
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-                     
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,              
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL            
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE                  
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM             
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,             
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER                
REMARK   3               : ZWART                                                
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.90                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 19.98                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.510                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.1                           
REMARK   3   NUMBER OF REFLECTIONS             : 83532                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.258                           
REMARK   3   R VALUE            (WORKING SET) : 0.255                           
REMARK   3   FREE R VALUE                     : 0.309                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 4.990                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 4171                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 19.9828 -  8.7597    1.00     2842   145  0.1926 0.2219        
REMARK   3     2  8.7597 -  7.0531    1.00     2754   152  0.2026 0.2388        
REMARK   3     3  7.0531 -  6.1918    1.00     2726   143  0.2218 0.2593        
REMARK   3     4  6.1918 -  5.6397    1.00     2679   148  0.2272 0.3152        
REMARK   3     5  5.6397 -  5.2433    1.00     2696   144  0.2178 0.2450        
REMARK   3     6  5.2433 -  4.9391    1.00     2684   137  0.1987 0.2646        
REMARK   3     7  4.9391 -  4.6951    1.00     2694   140  0.1979 0.2785        
REMARK   3     8  4.6951 -  4.4931    1.00     2661   149  0.2077 0.2566        
REMARK   3     9  4.4931 -  4.3219    1.00     2627   160  0.2072 0.2964        
REMARK   3    10  4.3219 -  4.1742    1.00     2665   135  0.2180 0.2720        
REMARK   3    11  4.1742 -  4.0448    1.00     2642   156  0.2269 0.2785        
REMARK   3    12  4.0448 -  3.9300    0.99     2621   162  0.2406 0.3091        
REMARK   3    13  3.9300 -  3.8273    1.00     2657   148  0.2520 0.3138        
REMARK   3    14  3.8273 -  3.7346    0.99     2631   131  0.2567 0.3469        
REMARK   3    15  3.7346 -  3.6502    0.99     2674   117  0.2633 0.3586        
REMARK   3    16  3.6502 -  3.5730    0.99     2611   133  0.2727 0.3340        
REMARK   3    17  3.5730 -  3.5019    0.99     2641   143  0.2767 0.3454        
REMARK   3    18  3.5019 -  3.4361    0.99     2664   132  0.2784 0.3382        
REMARK   3    19  3.4361 -  3.3750    0.99     2635   133  0.2850 0.3337        
REMARK   3    20  3.3750 -  3.3181    0.99     2598   143  0.3012 0.3700        
REMARK   3    21  3.3181 -  3.2648    0.99     2622   161  0.3167 0.3837        
REMARK   3    22  3.2648 -  3.2148    0.99     2590   131  0.3219 0.3508        
REMARK   3    23  3.2148 -  3.1677    0.99     2624   129  0.3218 0.4112        
REMARK   3    24  3.1677 -  3.1232    0.99     2629   123  0.3371 0.3500        
REMARK   3    25  3.1232 -  3.0812    0.99     2598   129  0.3485 0.4155        
REMARK   3    26  3.0812 -  3.0413    0.98     2582   137  0.3526 0.4310        
REMARK   3    27  3.0413 -  3.0034    0.98     2600   116  0.3604 0.3562        
REMARK   3    28  3.0034 -  2.9674    0.98     2602   107  0.3605 0.4233        
REMARK   3    29  2.9674 -  2.9330    0.97     2593   137  0.3749 0.3640        
REMARK   3    30  2.9330 -  2.9001    0.97     2519   150  0.3766 0.4094        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.600            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 32.500           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 43.49                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 63.95                          
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.003          21480                                  
REMARK   3   ANGLE     :  0.744          29045                                  
REMARK   3   CHIRALITY :  0.053           3305                                  
REMARK   3   PLANARITY :  0.003           3778                                  
REMARK   3   DIHEDRAL  : 13.294           7991                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 4Q7J COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 08-MAY-14.                  
REMARK 100 THE RCSB ID CODE IS RCSB085702.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 05-FEB-14                          
REMARK 200  TEMPERATURE           (KELVIN) : 95                                 
REMARK 200  PH                             : 8.0                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : PHOTON FACTORY                     
REMARK 200  BEAMLINE                       : BL-17A                             
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.98                               
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 270                   
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000                           
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 84212                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.900                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : NULL                               
REMARK 200  DATA REDUNDANCY                : NULL                               
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : NULL                               
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.90                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.95                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 86.2                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.30                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 2.580                              
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: 3AGP                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 55.48                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.76                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1M TRIS, 0.2M LITHIUM SULFATE, 20%     
REMARK 280  PEG3350, PH 8.0, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293K    
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21                       
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X+1/2,-Y,Z+1/2                                         
REMARK 290       3555   -X,Y+1/2,-Z+1/2                                         
REMARK 290       4555   X+1/2,-Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       66.09500            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       94.89000            
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       75.41500            
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       94.89000            
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       66.09500            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       75.41500            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 13330 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 61600 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -111.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC                        
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TETRAMERIC                 
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 13520 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 62030 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -117.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E, F, G, H                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     ALA A     1                                                      
REMARK 465     GLU A     2                                                      
REMARK 465     ILE A     3                                                      
REMARK 465     SER A   282                                                      
REMARK 465     SER B     1                                                      
REMARK 465     LYS B     2                                                      
REMARK 465     GLU B     3                                                      
REMARK 465     LYS B     4                                                      
REMARK 465     PHE B     5                                                      
REMARK 465     GLU B     6                                                      
REMARK 465     ARG B     7                                                      
REMARK 465     GLY B    41                                                      
REMARK 465     ALA B    42                                                      
REMARK 465     ALA B    43                                                      
REMARK 465     ARG B    44                                                      
REMARK 465     ALA B    45                                                      
REMARK 465     PHE B    46                                                      
REMARK 465     ASP B    47                                                      
REMARK 465     GLN B    48                                                      
REMARK 465     ILE B    49                                                      
REMARK 465     ASP B    50                                                      
REMARK 465     ASN B    51                                                      
REMARK 465     ALA B    52                                                      
REMARK 465     PRO B    53                                                      
REMARK 465     GLU B    54                                                      
REMARK 465     GLU B    55                                                      
REMARK 465     LYS B    56                                                      
REMARK 465     ALA B    57                                                      
REMARK 465     ARG B    58                                                      
REMARK 465     GLY B    59                                                      
REMARK 465     ILE B    60                                                      
REMARK 465     THR B    61                                                      
REMARK 465     ILE B    62                                                      
REMARK 465     ASN B    63                                                      
REMARK 465     THR B    64                                                      
REMARK 465     SER C     1                                                      
REMARK 465     LYS C     2                                                      
REMARK 465     THR C     3                                                      
REMARK 465     ALA C     4                                                      
REMARK 465     SER C     5                                                      
REMARK 465     SER C     6                                                      
REMARK 465     ARG C     7                                                      
REMARK 465     ASP C   522                                                      
REMARK 465     GLY C   523                                                      
REMARK 465     LEU C   524                                                      
REMARK 465     PRO C   525                                                      
REMARK 465     LEU C   526                                                      
REMARK 465     ARG C   527                                                      
REMARK 465     GLY C   528                                                      
REMARK 465     PRO C   529                                                      
REMARK 465     SER C   530                                                      
REMARK 465     GLY C   531                                                      
REMARK 465     CYS C   532                                                      
REMARK 465     ASP C   533                                                      
REMARK 465     SER C   534                                                      
REMARK 465     ALA C   535                                                      
REMARK 465     ASP C   536                                                      
REMARK 465     VAL C   570                                                      
REMARK 465     LEU C   571                                                      
REMARK 465     ALA C   572                                                      
REMARK 465     PRO C   573                                                      
REMARK 465     TYR C   574                                                      
REMARK 465     GLY C   575                                                      
REMARK 465     VAL C   576                                                      
REMARK 465     PHE C   577                                                      
REMARK 465     GLN C   578                                                      
REMARK 465     GLY C   579                                                      
REMARK 465     THR C   580                                                      
REMARK 465     LYS C   581                                                      
REMARK 465     VAL C   582                                                      
REMARK 465     ALA C   583                                                      
REMARK 465     SER C   584                                                      
REMARK 465     LEU C   585                                                      
REMARK 465     HIS C   586                                                      
REMARK 465     GLU C   587                                                      
REMARK 465     ALA C   588                                                      
REMARK 465     HIS C   589                                                      
REMARK 465     HIS C   590                                                      
REMARK 465     HIS C   591                                                      
REMARK 465     HIS C   592                                                      
REMARK 465     HIS C   593                                                      
REMARK 465     HIS C   594                                                      
REMARK 465     MET D     1                                                      
REMARK 465     THR D     2                                                      
REMARK 465     ALA D   180                                                      
REMARK 465     GLU D   181                                                      
REMARK 465     ARG D   182                                                      
REMARK 465     ASP D   183                                                      
REMARK 465     GLN D   184                                                      
REMARK 465     LEU D   185                                                      
REMARK 465     LEU D   186                                                      
REMARK 465     GLU D   187                                                      
REMARK 465     ASN D   188                                                      
REMARK 465     LEU D   189                                                      
REMARK 465     GLN D   190                                                      
REMARK 465     GLU D   191                                                      
REMARK 465     GLY D   192                                                      
REMARK 465     MET D   193                                                      
REMARK 465     GLU D   194                                                      
REMARK 465     VAL D   195                                                      
REMARK 465     LYS D   196                                                      
REMARK 465     GLY D   197                                                      
REMARK 465     ILE D   198                                                      
REMARK 465     VAL D   199                                                      
REMARK 465     LYS D   200                                                      
REMARK 465     ASN D   201                                                      
REMARK 465     LEU D   202                                                      
REMARK 465     THR D   203                                                      
REMARK 465     ASP D   204                                                      
REMARK 465     TYR D   205                                                      
REMARK 465     GLY D   206                                                      
REMARK 465     ALA D   207                                                      
REMARK 465     PHE D   208                                                      
REMARK 465     VAL D   209                                                      
REMARK 465     ASP D   210                                                      
REMARK 465     LEU D   211                                                      
REMARK 465     GLY D   212                                                      
REMARK 465     GLY D   213                                                      
REMARK 465     VAL D   214                                                      
REMARK 465     ASP D   215                                                      
REMARK 465     GLY D   216                                                      
REMARK 465     LEU D   217                                                      
REMARK 465     LEU D   218                                                      
REMARK 465     HIS D   219                                                      
REMARK 465     ILE D   220                                                      
REMARK 465     THR D   221                                                      
REMARK 465     ASP D   222                                                      
REMARK 465     MET D   223                                                      
REMARK 465     ALA D   224                                                      
REMARK 465     TRP D   225                                                      
REMARK 465     LYS D   226                                                      
REMARK 465     ARG D   227                                                      
REMARK 465     VAL D   228                                                      
REMARK 465     LYS D   229                                                      
REMARK 465     HIS D   230                                                      
REMARK 465     PRO D   231                                                      
REMARK 465     SER D   232                                                      
REMARK 465     GLU D   233                                                      
REMARK 465     ILE D   234                                                      
REMARK 465     VAL D   235                                                      
REMARK 465     ASN D   236                                                      
REMARK 465     VAL D   237                                                      
REMARK 465     GLY D   238                                                      
REMARK 465     ASP D   239                                                      
REMARK 465     GLU D   240                                                      
REMARK 465     ILE D   241                                                      
REMARK 465     THR D   242                                                      
REMARK 465     VAL D   243                                                      
REMARK 465     LYS D   244                                                      
REMARK 465     VAL D   245                                                      
REMARK 465     LEU D   246                                                      
REMARK 465     LYS D   247                                                      
REMARK 465     PHE D   248                                                      
REMARK 465     ASP D   249                                                      
REMARK 465     ARG D   250                                                      
REMARK 465     GLU D   251                                                      
REMARK 465     ARG D   252                                                      
REMARK 465     THR D   253                                                      
REMARK 465     ARG D   254                                                      
REMARK 465     VAL D   255                                                      
REMARK 465     SER D   256                                                      
REMARK 465     LEU D   257                                                      
REMARK 465     GLY D   258                                                      
REMARK 465     LEU D   259                                                      
REMARK 465     LYS D   260                                                      
REMARK 465     GLN D   261                                                      
REMARK 465     LEU D   262                                                      
REMARK 465     GLY D   263                                                      
REMARK 465     GLU D   264                                                      
REMARK 465     ASP D   265                                                      
REMARK 465     PRO D   266                                                      
REMARK 465     TRP D   267                                                      
REMARK 465     VAL D   268                                                      
REMARK 465     ALA D   269                                                      
REMARK 465     ILE D   270                                                      
REMARK 465     ALA D   271                                                      
REMARK 465     LYS D   272                                                      
REMARK 465     ARG D   273                                                      
REMARK 465     LEU D   274                                                      
REMARK 465     GLU D   275                                                      
REMARK 465     HIS D   276                                                      
REMARK 465     HIS D   277                                                      
REMARK 465     HIS D   278                                                      
REMARK 465     HIS D   279                                                      
REMARK 465     HIS D   280                                                      
REMARK 465     HIS D   281                                                      
REMARK 465     ALA E     1                                                      
REMARK 465     GLU E     2                                                      
REMARK 465     SER F     1                                                      
REMARK 465     LYS F     2                                                      
REMARK 465     GLU F     3                                                      
REMARK 465     LYS F     4                                                      
REMARK 465     PHE F     5                                                      
REMARK 465     GLU F     6                                                      
REMARK 465     GLY F    41                                                      
REMARK 465     ALA F    42                                                      
REMARK 465     ALA F    43                                                      
REMARK 465     ARG F    44                                                      
REMARK 465     ALA F    45                                                      
REMARK 465     PHE F    46                                                      
REMARK 465     ASP F    47                                                      
REMARK 465     GLN F    48                                                      
REMARK 465     ILE F    49                                                      
REMARK 465     ASP F    50                                                      
REMARK 465     ASN F    51                                                      
REMARK 465     ALA F    52                                                      
REMARK 465     PRO F    53                                                      
REMARK 465     GLU F    54                                                      
REMARK 465     GLU F    55                                                      
REMARK 465     LYS F    56                                                      
REMARK 465     ALA F    57                                                      
REMARK 465     ARG F    58                                                      
REMARK 465     GLY F    59                                                      
REMARK 465     ILE F    60                                                      
REMARK 465     THR F    61                                                      
REMARK 465     ILE F    62                                                      
REMARK 465     ASN F    63                                                      
REMARK 465     SER G     1                                                      
REMARK 465     LYS G     2                                                      
REMARK 465     THR G     3                                                      
REMARK 465     ALA G     4                                                      
REMARK 465     SER G     5                                                      
REMARK 465     SER G     6                                                      
REMARK 465     ARG G     7                                                      
REMARK 465     ASN G   521                                                      
REMARK 465     ASP G   522                                                      
REMARK 465     GLY G   523                                                      
REMARK 465     LEU G   524                                                      
REMARK 465     PRO G   525                                                      
REMARK 465     LEU G   526                                                      
REMARK 465     ARG G   527                                                      
REMARK 465     GLY G   528                                                      
REMARK 465     PRO G   529                                                      
REMARK 465     SER G   530                                                      
REMARK 465     GLY G   531                                                      
REMARK 465     CYS G   532                                                      
REMARK 465     ASP G   533                                                      
REMARK 465     SER G   534                                                      
REMARK 465     ALA G   535                                                      
REMARK 465     ASP G   536                                                      
REMARK 465     LEU G   537                                                      
REMARK 465     VAL G   570                                                      
REMARK 465     LEU G   571                                                      
REMARK 465     ALA G   572                                                      
REMARK 465     PRO G   573                                                      
REMARK 465     TYR G   574                                                      
REMARK 465     GLY G   575                                                      
REMARK 465     VAL G   576                                                      
REMARK 465     PHE G   577                                                      
REMARK 465     GLN G   578                                                      
REMARK 465     GLY G   579                                                      
REMARK 465     THR G   580                                                      
REMARK 465     LYS G   581                                                      
REMARK 465     VAL G   582                                                      
REMARK 465     ALA G   583                                                      
REMARK 465     SER G   584                                                      
REMARK 465     LEU G   585                                                      
REMARK 465     HIS G   586                                                      
REMARK 465     GLU G   587                                                      
REMARK 465     ALA G   588                                                      
REMARK 465     HIS G   589                                                      
REMARK 465     HIS G   590                                                      
REMARK 465     HIS G   591                                                      
REMARK 465     HIS G   592                                                      
REMARK 465     HIS G   593                                                      
REMARK 465     HIS G   594                                                      
REMARK 465     MET H     1                                                      
REMARK 465     SER H   179                                                      
REMARK 465     ALA H   180                                                      
REMARK 465     GLU H   181                                                      
REMARK 465     ARG H   182                                                      
REMARK 465     ASP H   183                                                      
REMARK 465     GLN H   184                                                      
REMARK 465     LEU H   185                                                      
REMARK 465     LEU H   186                                                      
REMARK 465     GLU H   187                                                      
REMARK 465     ASN H   188                                                      
REMARK 465     LEU H   189                                                      
REMARK 465     GLN H   190                                                      
REMARK 465     GLU H   191                                                      
REMARK 465     GLY H   192                                                      
REMARK 465     MET H   193                                                      
REMARK 465     GLU H   194                                                      
REMARK 465     VAL H   195                                                      
REMARK 465     LYS H   196                                                      
REMARK 465     GLY H   197                                                      
REMARK 465     ILE H   198                                                      
REMARK 465     VAL H   199                                                      
REMARK 465     LYS H   200                                                      
REMARK 465     ASN H   201                                                      
REMARK 465     LEU H   202                                                      
REMARK 465     THR H   203                                                      
REMARK 465     ASP H   204                                                      
REMARK 465     TYR H   205                                                      
REMARK 465     GLY H   206                                                      
REMARK 465     ALA H   207                                                      
REMARK 465     PHE H   208                                                      
REMARK 465     VAL H   209                                                      
REMARK 465     ASP H   210                                                      
REMARK 465     LEU H   211                                                      
REMARK 465     GLY H   212                                                      
REMARK 465     GLY H   213                                                      
REMARK 465     VAL H   214                                                      
REMARK 465     ASP H   215                                                      
REMARK 465     GLY H   216                                                      
REMARK 465     LEU H   217                                                      
REMARK 465     LEU H   218                                                      
REMARK 465     HIS H   219                                                      
REMARK 465     ILE H   220                                                      
REMARK 465     THR H   221                                                      
REMARK 465     ASP H   222                                                      
REMARK 465     MET H   223                                                      
REMARK 465     ALA H   224                                                      
REMARK 465     TRP H   225                                                      
REMARK 465     LYS H   226                                                      
REMARK 465     ARG H   227                                                      
REMARK 465     VAL H   228                                                      
REMARK 465     LYS H   229                                                      
REMARK 465     HIS H   230                                                      
REMARK 465     PRO H   231                                                      
REMARK 465     SER H   232                                                      
REMARK 465     GLU H   233                                                      
REMARK 465     ILE H   234                                                      
REMARK 465     VAL H   235                                                      
REMARK 465     ASN H   236                                                      
REMARK 465     VAL H   237                                                      
REMARK 465     GLY H   238                                                      
REMARK 465     ASP H   239                                                      
REMARK 465     GLU H   240                                                      
REMARK 465     ILE H   241                                                      
REMARK 465     THR H   242                                                      
REMARK 465     VAL H   243                                                      
REMARK 465     LYS H   244                                                      
REMARK 465     VAL H   245                                                      
REMARK 465     LEU H   246                                                      
REMARK 465     LYS H   247                                                      
REMARK 465     PHE H   248                                                      
REMARK 465     ASP H   249                                                      
REMARK 465     ARG H   250                                                      
REMARK 465     GLU H   251                                                      
REMARK 465     ARG H   252                                                      
REMARK 465     THR H   253                                                      
REMARK 465     ARG H   254                                                      
REMARK 465     VAL H   255                                                      
REMARK 465     SER H   256                                                      
REMARK 465     LEU H   257                                                      
REMARK 465     GLY H   258                                                      
REMARK 465     LEU H   259                                                      
REMARK 465     LYS H   260                                                      
REMARK 465     GLN H   261                                                      
REMARK 465     LEU H   262                                                      
REMARK 465     GLY H   263                                                      
REMARK 465     GLU H   264                                                      
REMARK 465     ASP H   265                                                      
REMARK 465     PRO H   266                                                      
REMARK 465     TRP H   267                                                      
REMARK 465     VAL H   268                                                      
REMARK 465     ALA H   269                                                      
REMARK 465     ILE H   270                                                      
REMARK 465     ALA H   271                                                      
REMARK 465     LYS H   272                                                      
REMARK 465     ARG H   273                                                      
REMARK 465     LEU H   274                                                      
REMARK 465     GLU H   275                                                      
REMARK 465     HIS H   276                                                      
REMARK 465     HIS H   277                                                      
REMARK 465     HIS H   278                                                      
REMARK 465     HIS H   279                                                      
REMARK 465     HIS H   280                                                      
REMARK 465     HIS H   281                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LEU C 537    CG   CD1  CD2                                       
REMARK 470     PHE C 538    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG C 569    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU D   3    CG   CD   OE1  OE2                                  
REMARK 470     ARG D 170    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER D 179    OG                                                  
REMARK 470     ARG F   7    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE G 538    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG G 569    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG H 170    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU H 177    CG   CD   OE1  OE2                                  
REMARK 470     ASN H 178    CG   OD1  ND2                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    THR A  15      -62.19   -108.42                                   
REMARK 500    ALA A 160     -139.32     52.64                                   
REMARK 500    GLU A 265      -15.27     75.28                                   
REMARK 500    LYS A 266       76.16     48.86                                   
REMARK 500    THR B  38      -73.05   -102.19                                   
REMARK 500    THR B  73      -62.04   -104.08                                   
REMARK 500    ASP B 109      -62.49    -94.99                                   
REMARK 500    ASP B 161       -3.15     85.74                                   
REMARK 500    PRO B 163       74.53    -68.73                                   
REMARK 500    ARG B 223      -58.99   -127.15                                   
REMARK 500    THR B 302      -62.42   -124.34                                   
REMARK 500    ARG B 333      -25.63     62.01                                   
REMARK 500    THR B 334      -63.89   -140.02                                   
REMARK 500    GLU B 348      -60.42   -127.76                                   
REMARK 500    ALA B 389      -68.87    -95.29                                   
REMARK 500    ASP C  59      174.97    173.41                                   
REMARK 500    GLU C 116      -71.35   -137.64                                   
REMARK 500    ASP C 117     -161.90   -167.48                                   
REMARK 500    PHE C 118       -5.83     89.64                                   
REMARK 500    ASN C 119       71.76     55.84                                   
REMARK 500    THR C 160      -66.26   -107.97                                   
REMARK 500    LYS C 213      -63.82   -128.97                                   
REMARK 500    VAL C 265      -63.78    -90.88                                   
REMARK 500    LYS C 385      -61.81   -107.64                                   
REMARK 500    GLU C 389      -61.98   -130.26                                   
REMARK 500    VAL C 416      -63.35   -129.15                                   
REMARK 500    ALA D  50      -76.75    -88.64                                   
REMARK 500    GLU D  51     -132.96     46.41                                   
REMARK 500    PHE D  53      -79.80   -101.64                                   
REMARK 500    ASN D  55      -73.30   -136.32                                   
REMARK 500    GLU D  61      -70.80    -55.65                                   
REMARK 500    GLU D 103       82.39     64.58                                   
REMARK 500    ASP D 104       73.22     66.51                                   
REMARK 500    LYS D 117      -71.06    -69.94                                   
REMARK 500    ASN D 125     -128.79     51.70                                   
REMARK 500    GLN D 161      -15.23     67.64                                   
REMARK 500    LYS D 162      -73.39   -124.51                                   
REMARK 500    ALA E   5      -75.72   -121.27                                   
REMARK 500    ARG E  14      -63.48    -93.66                                   
REMARK 500    ALA E 101      -73.75    -57.72                                   
REMARK 500    PRO E 207     -179.24    -63.07                                   
REMARK 500    ILE E 210      -63.75   -100.23                                   
REMARK 500    ILE E 264       -6.01     68.44                                   
REMARK 500    GLU E 265       -7.83     86.36                                   
REMARK 500    LYS F  24      -70.93    -48.38                                   
REMARK 500    THR F  38      -63.05   -103.01                                   
REMARK 500    PRO F  82       48.98    -89.71                                   
REMARK 500    ASP F 109      -62.52   -104.44                                   
REMARK 500    ASP F 161       39.41     39.80                                   
REMARK 500    ARG F 223      -58.97   -127.91                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      82 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 C 601                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 C 602                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 G 601                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 G 602                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 3AGP   RELATED DB: PDB                                   
REMARK 900 RELATED ID: 3AGQ   RELATED DB: PDB                                   
DBREF  4Q7J A    1   282  UNP    P0A6P1   EFTS_ECOLI       2    283             
DBREF  4Q7J B    1   393  UNP    P0CE47   EFTU1_ECOLI      2    394             
DBREF  4Q7J C    1   588  UNP    Q8LTE0   Q8LTE0_BPQBE     2    589             
DBREF  4Q7J D    1   273  UNP    P0AG67   RS1_ECOLI        1    273             
DBREF  4Q7J E    1   282  UNP    P0A6P1   EFTS_ECOLI       2    283             
DBREF  4Q7J F    1   393  UNP    P0CE47   EFTU1_ECOLI      2    394             
DBREF  4Q7J G    1   588  UNP    Q8LTE0   Q8LTE0_BPQBE     2    589             
DBREF  4Q7J H    1   273  UNP    P0AG67   RS1_ECOLI        1    273             
SEQADV 4Q7J HIS C  589  UNP  Q8LTE0              EXPRESSION TAG                 
SEQADV 4Q7J HIS C  590  UNP  Q8LTE0              EXPRESSION TAG                 
SEQADV 4Q7J HIS C  591  UNP  Q8LTE0              EXPRESSION TAG                 
SEQADV 4Q7J HIS C  592  UNP  Q8LTE0              EXPRESSION TAG                 
SEQADV 4Q7J HIS C  593  UNP  Q8LTE0              EXPRESSION TAG                 
SEQADV 4Q7J HIS C  594  UNP  Q8LTE0              EXPRESSION TAG                 
SEQADV 4Q7J LEU D  274  UNP  P0AG67              EXPRESSION TAG                 
SEQADV 4Q7J GLU D  275  UNP  P0AG67              EXPRESSION TAG                 
SEQADV 4Q7J HIS D  276  UNP  P0AG67              EXPRESSION TAG                 
SEQADV 4Q7J HIS D  277  UNP  P0AG67              EXPRESSION TAG                 
SEQADV 4Q7J HIS D  278  UNP  P0AG67              EXPRESSION TAG                 
SEQADV 4Q7J HIS D  279  UNP  P0AG67              EXPRESSION TAG                 
SEQADV 4Q7J HIS D  280  UNP  P0AG67              EXPRESSION TAG                 
SEQADV 4Q7J HIS D  281  UNP  P0AG67              EXPRESSION TAG                 
SEQADV 4Q7J HIS G  589  UNP  Q8LTE0              EXPRESSION TAG                 
SEQADV 4Q7J HIS G  590  UNP  Q8LTE0              EXPRESSION TAG                 
SEQADV 4Q7J HIS G  591  UNP  Q8LTE0              EXPRESSION TAG                 
SEQADV 4Q7J HIS G  592  UNP  Q8LTE0              EXPRESSION TAG                 
SEQADV 4Q7J HIS G  593  UNP  Q8LTE0              EXPRESSION TAG                 
SEQADV 4Q7J HIS G  594  UNP  Q8LTE0              EXPRESSION TAG                 
SEQADV 4Q7J LEU H  274  UNP  P0AG67              EXPRESSION TAG                 
SEQADV 4Q7J GLU H  275  UNP  P0AG67              EXPRESSION TAG                 
SEQADV 4Q7J HIS H  276  UNP  P0AG67              EXPRESSION TAG                 
SEQADV 4Q7J HIS H  277  UNP  P0AG67              EXPRESSION TAG                 
SEQADV 4Q7J HIS H  278  UNP  P0AG67              EXPRESSION TAG                 
SEQADV 4Q7J HIS H  279  UNP  P0AG67              EXPRESSION TAG                 
SEQADV 4Q7J HIS H  280  UNP  P0AG67              EXPRESSION TAG                 
SEQADV 4Q7J HIS H  281  UNP  P0AG67              EXPRESSION TAG                 
SEQRES   1 A  282  ALA GLU ILE THR ALA SER LEU VAL LYS GLU LEU ARG GLU          
SEQRES   2 A  282  ARG THR GLY ALA GLY MET MET ASP CYS LYS LYS ALA LEU          
SEQRES   3 A  282  THR GLU ALA ASN GLY ASP ILE GLU LEU ALA ILE GLU ASN          
SEQRES   4 A  282  MET ARG LYS SER GLY ALA ILE LYS ALA ALA LYS LYS ALA          
SEQRES   5 A  282  GLY ASN VAL ALA ALA ASP GLY VAL ILE LYS THR LYS ILE          
SEQRES   6 A  282  ASP GLY ASN TYR GLY ILE ILE LEU GLU VAL ASN CYS GLN          
SEQRES   7 A  282  THR ASP PHE VAL ALA LYS ASP ALA GLY PHE GLN ALA PHE          
SEQRES   8 A  282  ALA ASP LYS VAL LEU ASP ALA ALA VAL ALA GLY LYS ILE          
SEQRES   9 A  282  THR ASP VAL GLU VAL LEU LYS ALA GLN PHE GLU GLU GLU          
SEQRES  10 A  282  ARG VAL ALA LEU VAL ALA LYS ILE GLY GLU ASN ILE ASN          
SEQRES  11 A  282  ILE ARG ARG VAL ALA ALA LEU GLU GLY ASP VAL LEU GLY          
SEQRES  12 A  282  SER TYR GLN HIS GLY ALA ARG ILE GLY VAL LEU VAL ALA          
SEQRES  13 A  282  ALA LYS GLY ALA ASP GLU GLU LEU VAL LYS HIS ILE ALA          
SEQRES  14 A  282  MET HIS VAL ALA ALA SER LYS PRO GLU PHE ILE LYS PRO          
SEQRES  15 A  282  GLU ASP VAL SER ALA GLU VAL VAL GLU LYS GLU TYR GLN          
SEQRES  16 A  282  VAL GLN LEU ASP ILE ALA MET GLN SER GLY LYS PRO LYS          
SEQRES  17 A  282  GLU ILE ALA GLU LYS MET VAL GLU GLY ARG MET LYS LYS          
SEQRES  18 A  282  PHE THR GLY GLU VAL SER LEU THR GLY GLN PRO PHE VAL          
SEQRES  19 A  282  MET GLU PRO SER LYS THR VAL GLY GLN LEU LEU LYS GLU          
SEQRES  20 A  282  HIS ASN ALA GLU VAL THR GLY PHE ILE ARG PHE GLU VAL          
SEQRES  21 A  282  GLY GLU GLY ILE GLU LYS VAL GLU THR ASP PHE ALA ALA          
SEQRES  22 A  282  GLU VAL ALA ALA MET SER LYS GLN SER                          
SEQRES   1 B  393  SER LYS GLU LYS PHE GLU ARG THR LYS PRO HIS VAL ASN          
SEQRES   2 B  393  VAL GLY THR ILE GLY HIS VAL ASP HIS GLY LYS THR THR          
SEQRES   3 B  393  LEU THR ALA ALA ILE THR THR VAL LEU ALA LYS THR TYR          
SEQRES   4 B  393  GLY GLY ALA ALA ARG ALA PHE ASP GLN ILE ASP ASN ALA          
SEQRES   5 B  393  PRO GLU GLU LYS ALA ARG GLY ILE THR ILE ASN THR SER          
SEQRES   6 B  393  HIS VAL GLU TYR ASP THR PRO THR ARG HIS TYR ALA HIS          
SEQRES   7 B  393  VAL ASP CYS PRO GLY HIS ALA ASP TYR VAL LYS ASN MET          
SEQRES   8 B  393  ILE THR GLY ALA ALA GLN MET ASP GLY ALA ILE LEU VAL          
SEQRES   9 B  393  VAL ALA ALA THR ASP GLY PRO MET PRO GLN THR ARG GLU          
SEQRES  10 B  393  HIS ILE LEU LEU GLY ARG GLN VAL GLY VAL PRO TYR ILE          
SEQRES  11 B  393  ILE VAL PHE LEU ASN LYS CYS ASP MET VAL ASP ASP GLU          
SEQRES  12 B  393  GLU LEU LEU GLU LEU VAL GLU MET GLU VAL ARG GLU LEU          
SEQRES  13 B  393  LEU SER GLN TYR ASP PHE PRO GLY ASP ASP THR PRO ILE          
SEQRES  14 B  393  VAL ARG GLY SER ALA LEU LYS ALA LEU GLU GLY ASP ALA          
SEQRES  15 B  393  GLU TRP GLU ALA LYS ILE LEU GLU LEU ALA GLY PHE LEU          
SEQRES  16 B  393  ASP SER TYR ILE PRO GLU PRO GLU ARG ALA ILE ASP LYS          
SEQRES  17 B  393  PRO PHE LEU LEU PRO ILE GLU ASP VAL PHE SER ILE SER          
SEQRES  18 B  393  GLY ARG GLY THR VAL VAL THR GLY ARG VAL GLU ARG GLY          
SEQRES  19 B  393  ILE ILE LYS VAL GLY GLU GLU VAL GLU ILE VAL GLY ILE          
SEQRES  20 B  393  LYS GLU THR GLN LYS SER THR CYS THR GLY VAL GLU MET          
SEQRES  21 B  393  PHE ARG LYS LEU LEU ASP GLU GLY ARG ALA GLY GLU ASN          
SEQRES  22 B  393  VAL GLY VAL LEU LEU ARG GLY ILE LYS ARG GLU GLU ILE          
SEQRES  23 B  393  GLU ARG GLY GLN VAL LEU ALA LYS PRO GLY THR ILE LYS          
SEQRES  24 B  393  PRO HIS THR LYS PHE GLU SER GLU VAL TYR ILE LEU SER          
SEQRES  25 B  393  LYS ASP GLU GLY GLY ARG HIS THR PRO PHE PHE LYS GLY          
SEQRES  26 B  393  TYR ARG PRO GLN PHE TYR PHE ARG THR THR ASP VAL THR          
SEQRES  27 B  393  GLY THR ILE GLU LEU PRO GLU GLY VAL GLU MET VAL MET          
SEQRES  28 B  393  PRO GLY ASP ASN ILE LYS MET VAL VAL THR LEU ILE HIS          
SEQRES  29 B  393  PRO ILE ALA MET ASP ASP GLY LEU ARG PHE ALA ILE ARG          
SEQRES  30 B  393  GLU GLY GLY ARG THR VAL GLY ALA GLY VAL VAL ALA LYS          
SEQRES  31 B  393  VAL LEU GLY                                                  
SEQRES   1 C  594  SER LYS THR ALA SER SER ARG ASN SER LEU SER ALA GLN          
SEQRES   2 C  594  LEU ARG ARG ALA ALA ASN THR ARG ILE GLU VAL GLU GLY          
SEQRES   3 C  594  ASN LEU ALA LEU SER ILE ALA ASN ASP LEU LEU LEU ALA          
SEQRES   4 C  594  TYR GLY GLN SER PRO PHE ASN SER GLU ALA GLU CYS ILE          
SEQRES   5 C  594  SER PHE SER PRO ARG PHE ASP GLY THR PRO ASP ASP PHE          
SEQRES   6 C  594  ARG ILE ASN TYR LEU LYS ALA GLU ILE MET SER LYS TYR          
SEQRES   7 C  594  ASP ASP PHE SER LEU GLY ILE ASP THR GLU ALA VAL ALA          
SEQRES   8 C  594  TRP GLU LYS PHE LEU ALA ALA GLU ALA GLU CYS ALA LEU          
SEQRES   9 C  594  THR ASN ALA ARG LEU TYR ARG PRO ASP TYR SER GLU ASP          
SEQRES  10 C  594  PHE ASN PHE SER LEU GLY GLU SER CYS ILE HIS MET ALA          
SEQRES  11 C  594  ARG ARG LYS ILE ALA LYS LEU ILE GLY ASP VAL PRO SER          
SEQRES  12 C  594  VAL GLU GLY MET LEU ARG HIS CYS ARG PHE SER GLY GLY          
SEQRES  13 C  594  ALA THR THR THR ASN ASN ARG SER TYR GLY HIS PRO SER          
SEQRES  14 C  594  PHE LYS PHE ALA LEU PRO GLN ALA CYS THR PRO ARG ALA          
SEQRES  15 C  594  LEU LYS TYR VAL LEU ALA LEU ARG ALA SER THR HIS PHE          
SEQRES  16 C  594  ASP ILE ARG ILE SER ASP ILE SER PRO PHE ASN LYS ALA          
SEQRES  17 C  594  VAL THR VAL PRO LYS ASN SER LYS THR ASP ARG CYS ILE          
SEQRES  18 C  594  ALA ILE GLU PRO GLY TRP ASN MET PHE PHE GLN LEU GLY          
SEQRES  19 C  594  ILE GLY GLY ILE LEU ARG ASP ARG LEU ARG CYS TRP GLY          
SEQRES  20 C  594  ILE ASP LEU ASN ASP GLN THR ILE ASN GLN ARG ARG ALA          
SEQRES  21 C  594  HIS GLU GLY SER VAL THR ASN ASN LEU ALA THR VAL ASP          
SEQRES  22 C  594  LEU SER ALA ALA SER ASP SER ILE SER LEU ALA LEU CYS          
SEQRES  23 C  594  GLU LEU LEU LEU PRO PRO GLY TRP PHE GLU VAL LEU MET          
SEQRES  24 C  594  ASP LEU ARG SER PRO LYS GLY ARG LEU PRO ASP GLY SER          
SEQRES  25 C  594  VAL VAL THR TYR GLU LYS ILE SER SER MET GLY ASN GLY          
SEQRES  26 C  594  TYR THR PHE GLU LEU GLU SER LEU ILE PHE ALA SER LEU          
SEQRES  27 C  594  ALA ARG SER VAL CYS GLU ILE LEU ASP LEU ASP SER SER          
SEQRES  28 C  594  GLU VAL THR VAL TYR GLY ASP ASP ILE ILE LEU PRO SER          
SEQRES  29 C  594  CYS ALA VAL PRO ALA LEU ARG GLU VAL PHE LYS TYR VAL          
SEQRES  30 C  594  GLY PHE THR THR ASN THR LYS LYS THR PHE SER GLU GLY          
SEQRES  31 C  594  PRO PHE ARG GLU SER CYS GLY LYS HIS TYR TYR SER GLY          
SEQRES  32 C  594  VAL ASP VAL THR PRO PHE TYR ILE ARG HIS ARG ILE VAL          
SEQRES  33 C  594  SER PRO ALA ASP LEU ILE LEU VAL LEU ASN ASN LEU TYR          
SEQRES  34 C  594  ARG TRP ALA THR ILE ASP GLY VAL TRP ASP PRO ARG ALA          
SEQRES  35 C  594  HIS SER VAL TYR LEU LYS TYR ARG LYS LEU LEU PRO LYS          
SEQRES  36 C  594  GLN LEU GLN ARG ASN THR ILE PRO ASP GLY TYR GLY ASP          
SEQRES  37 C  594  GLY ALA LEU VAL GLY SER VAL LEU ILE ASN PRO PHE ALA          
SEQRES  38 C  594  LYS ASN ARG GLY TRP ILE ARG TYR VAL PRO VAL ILE THR          
SEQRES  39 C  594  ASP HIS THR ARG ASP ARG GLU ARG ALA GLU LEU GLY SER          
SEQRES  40 C  594  TYR LEU TYR ASP LEU PHE SER ARG CYS LEU SER GLU SER          
SEQRES  41 C  594  ASN ASP GLY LEU PRO LEU ARG GLY PRO SER GLY CYS ASP          
SEQRES  42 C  594  SER ALA ASP LEU PHE ALA ILE ASP GLN LEU ILE CYS ARG          
SEQRES  43 C  594  SER ASN PRO THR LYS ILE SER ARG SER THR GLY LYS PHE          
SEQRES  44 C  594  ASP ILE GLN TYR ILE ALA CYS SER SER ARG VAL LEU ALA          
SEQRES  45 C  594  PRO TYR GLY VAL PHE GLN GLY THR LYS VAL ALA SER LEU          
SEQRES  46 C  594  HIS GLU ALA HIS HIS HIS HIS HIS HIS                          
SEQRES   1 D  281  MET THR GLU SER PHE ALA GLN LEU PHE GLU GLU SER LEU          
SEQRES   2 D  281  LYS GLU ILE GLU THR ARG PRO GLY SER ILE VAL ARG GLY          
SEQRES   3 D  281  VAL VAL VAL ALA ILE ASP LYS ASP VAL VAL LEU VAL ASP          
SEQRES   4 D  281  ALA GLY LEU LYS SER GLU SER ALA ILE PRO ALA GLU GLN          
SEQRES   5 D  281  PHE LYS ASN ALA GLN GLY GLU LEU GLU ILE GLN VAL GLY          
SEQRES   6 D  281  ASP GLU VAL ASP VAL ALA LEU ASP ALA VAL GLU ASP GLY          
SEQRES   7 D  281  PHE GLY GLU THR LEU LEU SER ARG GLU LYS ALA LYS ARG          
SEQRES   8 D  281  HIS GLU ALA TRP ILE THR LEU GLU LYS ALA TYR GLU ASP          
SEQRES   9 D  281  ALA GLU THR VAL THR GLY VAL ILE ASN GLY LYS VAL LYS          
SEQRES  10 D  281  GLY GLY PHE THR VAL GLU LEU ASN GLY ILE ARG ALA PHE          
SEQRES  11 D  281  LEU PRO GLY SER LEU VAL ASP VAL ARG PRO VAL ARG ASP          
SEQRES  12 D  281  THR LEU HIS LEU GLU GLY LYS GLU LEU GLU PHE LYS VAL          
SEQRES  13 D  281  ILE LYS LEU ASP GLN LYS ARG ASN ASN VAL VAL VAL SER          
SEQRES  14 D  281  ARG ARG ALA VAL ILE GLU SER GLU ASN SER ALA GLU ARG          
SEQRES  15 D  281  ASP GLN LEU LEU GLU ASN LEU GLN GLU GLY MET GLU VAL          
SEQRES  16 D  281  LYS GLY ILE VAL LYS ASN LEU THR ASP TYR GLY ALA PHE          
SEQRES  17 D  281  VAL ASP LEU GLY GLY VAL ASP GLY LEU LEU HIS ILE THR          
SEQRES  18 D  281  ASP MET ALA TRP LYS ARG VAL LYS HIS PRO SER GLU ILE          
SEQRES  19 D  281  VAL ASN VAL GLY ASP GLU ILE THR VAL LYS VAL LEU LYS          
SEQRES  20 D  281  PHE ASP ARG GLU ARG THR ARG VAL SER LEU GLY LEU LYS          
SEQRES  21 D  281  GLN LEU GLY GLU ASP PRO TRP VAL ALA ILE ALA LYS ARG          
SEQRES  22 D  281  LEU GLU HIS HIS HIS HIS HIS HIS                              
SEQRES   1 E  282  ALA GLU ILE THR ALA SER LEU VAL LYS GLU LEU ARG GLU          
SEQRES   2 E  282  ARG THR GLY ALA GLY MET MET ASP CYS LYS LYS ALA LEU          
SEQRES   3 E  282  THR GLU ALA ASN GLY ASP ILE GLU LEU ALA ILE GLU ASN          
SEQRES   4 E  282  MET ARG LYS SER GLY ALA ILE LYS ALA ALA LYS LYS ALA          
SEQRES   5 E  282  GLY ASN VAL ALA ALA ASP GLY VAL ILE LYS THR LYS ILE          
SEQRES   6 E  282  ASP GLY ASN TYR GLY ILE ILE LEU GLU VAL ASN CYS GLN          
SEQRES   7 E  282  THR ASP PHE VAL ALA LYS ASP ALA GLY PHE GLN ALA PHE          
SEQRES   8 E  282  ALA ASP LYS VAL LEU ASP ALA ALA VAL ALA GLY LYS ILE          
SEQRES   9 E  282  THR ASP VAL GLU VAL LEU LYS ALA GLN PHE GLU GLU GLU          
SEQRES  10 E  282  ARG VAL ALA LEU VAL ALA LYS ILE GLY GLU ASN ILE ASN          
SEQRES  11 E  282  ILE ARG ARG VAL ALA ALA LEU GLU GLY ASP VAL LEU GLY          
SEQRES  12 E  282  SER TYR GLN HIS GLY ALA ARG ILE GLY VAL LEU VAL ALA          
SEQRES  13 E  282  ALA LYS GLY ALA ASP GLU GLU LEU VAL LYS HIS ILE ALA          
SEQRES  14 E  282  MET HIS VAL ALA ALA SER LYS PRO GLU PHE ILE LYS PRO          
SEQRES  15 E  282  GLU ASP VAL SER ALA GLU VAL VAL GLU LYS GLU TYR GLN          
SEQRES  16 E  282  VAL GLN LEU ASP ILE ALA MET GLN SER GLY LYS PRO LYS          
SEQRES  17 E  282  GLU ILE ALA GLU LYS MET VAL GLU GLY ARG MET LYS LYS          
SEQRES  18 E  282  PHE THR GLY GLU VAL SER LEU THR GLY GLN PRO PHE VAL          
SEQRES  19 E  282  MET GLU PRO SER LYS THR VAL GLY GLN LEU LEU LYS GLU          
SEQRES  20 E  282  HIS ASN ALA GLU VAL THR GLY PHE ILE ARG PHE GLU VAL          
SEQRES  21 E  282  GLY GLU GLY ILE GLU LYS VAL GLU THR ASP PHE ALA ALA          
SEQRES  22 E  282  GLU VAL ALA ALA MET SER LYS GLN SER                          
SEQRES   1 F  393  SER LYS GLU LYS PHE GLU ARG THR LYS PRO HIS VAL ASN          
SEQRES   2 F  393  VAL GLY THR ILE GLY HIS VAL ASP HIS GLY LYS THR THR          
SEQRES   3 F  393  LEU THR ALA ALA ILE THR THR VAL LEU ALA LYS THR TYR          
SEQRES   4 F  393  GLY GLY ALA ALA ARG ALA PHE ASP GLN ILE ASP ASN ALA          
SEQRES   5 F  393  PRO GLU GLU LYS ALA ARG GLY ILE THR ILE ASN THR SER          
SEQRES   6 F  393  HIS VAL GLU TYR ASP THR PRO THR ARG HIS TYR ALA HIS          
SEQRES   7 F  393  VAL ASP CYS PRO GLY HIS ALA ASP TYR VAL LYS ASN MET          
SEQRES   8 F  393  ILE THR GLY ALA ALA GLN MET ASP GLY ALA ILE LEU VAL          
SEQRES   9 F  393  VAL ALA ALA THR ASP GLY PRO MET PRO GLN THR ARG GLU          
SEQRES  10 F  393  HIS ILE LEU LEU GLY ARG GLN VAL GLY VAL PRO TYR ILE          
SEQRES  11 F  393  ILE VAL PHE LEU ASN LYS CYS ASP MET VAL ASP ASP GLU          
SEQRES  12 F  393  GLU LEU LEU GLU LEU VAL GLU MET GLU VAL ARG GLU LEU          
SEQRES  13 F  393  LEU SER GLN TYR ASP PHE PRO GLY ASP ASP THR PRO ILE          
SEQRES  14 F  393  VAL ARG GLY SER ALA LEU LYS ALA LEU GLU GLY ASP ALA          
SEQRES  15 F  393  GLU TRP GLU ALA LYS ILE LEU GLU LEU ALA GLY PHE LEU          
SEQRES  16 F  393  ASP SER TYR ILE PRO GLU PRO GLU ARG ALA ILE ASP LYS          
SEQRES  17 F  393  PRO PHE LEU LEU PRO ILE GLU ASP VAL PHE SER ILE SER          
SEQRES  18 F  393  GLY ARG GLY THR VAL VAL THR GLY ARG VAL GLU ARG GLY          
SEQRES  19 F  393  ILE ILE LYS VAL GLY GLU GLU VAL GLU ILE VAL GLY ILE          
SEQRES  20 F  393  LYS GLU THR GLN LYS SER THR CYS THR GLY VAL GLU MET          
SEQRES  21 F  393  PHE ARG LYS LEU LEU ASP GLU GLY ARG ALA GLY GLU ASN          
SEQRES  22 F  393  VAL GLY VAL LEU LEU ARG GLY ILE LYS ARG GLU GLU ILE          
SEQRES  23 F  393  GLU ARG GLY GLN VAL LEU ALA LYS PRO GLY THR ILE LYS          
SEQRES  24 F  393  PRO HIS THR LYS PHE GLU SER GLU VAL TYR ILE LEU SER          
SEQRES  25 F  393  LYS ASP GLU GLY GLY ARG HIS THR PRO PHE PHE LYS GLY          
SEQRES  26 F  393  TYR ARG PRO GLN PHE TYR PHE ARG THR THR ASP VAL THR          
SEQRES  27 F  393  GLY THR ILE GLU LEU PRO GLU GLY VAL GLU MET VAL MET          
SEQRES  28 F  393  PRO GLY ASP ASN ILE LYS MET VAL VAL THR LEU ILE HIS          
SEQRES  29 F  393  PRO ILE ALA MET ASP ASP GLY LEU ARG PHE ALA ILE ARG          
SEQRES  30 F  393  GLU GLY GLY ARG THR VAL GLY ALA GLY VAL VAL ALA LYS          
SEQRES  31 F  393  VAL LEU GLY                                                  
SEQRES   1 G  594  SER LYS THR ALA SER SER ARG ASN SER LEU SER ALA GLN          
SEQRES   2 G  594  LEU ARG ARG ALA ALA ASN THR ARG ILE GLU VAL GLU GLY          
SEQRES   3 G  594  ASN LEU ALA LEU SER ILE ALA ASN ASP LEU LEU LEU ALA          
SEQRES   4 G  594  TYR GLY GLN SER PRO PHE ASN SER GLU ALA GLU CYS ILE          
SEQRES   5 G  594  SER PHE SER PRO ARG PHE ASP GLY THR PRO ASP ASP PHE          
SEQRES   6 G  594  ARG ILE ASN TYR LEU LYS ALA GLU ILE MET SER LYS TYR          
SEQRES   7 G  594  ASP ASP PHE SER LEU GLY ILE ASP THR GLU ALA VAL ALA          
SEQRES   8 G  594  TRP GLU LYS PHE LEU ALA ALA GLU ALA GLU CYS ALA LEU          
SEQRES   9 G  594  THR ASN ALA ARG LEU TYR ARG PRO ASP TYR SER GLU ASP          
SEQRES  10 G  594  PHE ASN PHE SER LEU GLY GLU SER CYS ILE HIS MET ALA          
SEQRES  11 G  594  ARG ARG LYS ILE ALA LYS LEU ILE GLY ASP VAL PRO SER          
SEQRES  12 G  594  VAL GLU GLY MET LEU ARG HIS CYS ARG PHE SER GLY GLY          
SEQRES  13 G  594  ALA THR THR THR ASN ASN ARG SER TYR GLY HIS PRO SER          
SEQRES  14 G  594  PHE LYS PHE ALA LEU PRO GLN ALA CYS THR PRO ARG ALA          
SEQRES  15 G  594  LEU LYS TYR VAL LEU ALA LEU ARG ALA SER THR HIS PHE          
SEQRES  16 G  594  ASP ILE ARG ILE SER ASP ILE SER PRO PHE ASN LYS ALA          
SEQRES  17 G  594  VAL THR VAL PRO LYS ASN SER LYS THR ASP ARG CYS ILE          
SEQRES  18 G  594  ALA ILE GLU PRO GLY TRP ASN MET PHE PHE GLN LEU GLY          
SEQRES  19 G  594  ILE GLY GLY ILE LEU ARG ASP ARG LEU ARG CYS TRP GLY          
SEQRES  20 G  594  ILE ASP LEU ASN ASP GLN THR ILE ASN GLN ARG ARG ALA          
SEQRES  21 G  594  HIS GLU GLY SER VAL THR ASN ASN LEU ALA THR VAL ASP          
SEQRES  22 G  594  LEU SER ALA ALA SER ASP SER ILE SER LEU ALA LEU CYS          
SEQRES  23 G  594  GLU LEU LEU LEU PRO PRO GLY TRP PHE GLU VAL LEU MET          
SEQRES  24 G  594  ASP LEU ARG SER PRO LYS GLY ARG LEU PRO ASP GLY SER          
SEQRES  25 G  594  VAL VAL THR TYR GLU LYS ILE SER SER MET GLY ASN GLY          
SEQRES  26 G  594  TYR THR PHE GLU LEU GLU SER LEU ILE PHE ALA SER LEU          
SEQRES  27 G  594  ALA ARG SER VAL CYS GLU ILE LEU ASP LEU ASP SER SER          
SEQRES  28 G  594  GLU VAL THR VAL TYR GLY ASP ASP ILE ILE LEU PRO SER          
SEQRES  29 G  594  CYS ALA VAL PRO ALA LEU ARG GLU VAL PHE LYS TYR VAL          
SEQRES  30 G  594  GLY PHE THR THR ASN THR LYS LYS THR PHE SER GLU GLY          
SEQRES  31 G  594  PRO PHE ARG GLU SER CYS GLY LYS HIS TYR TYR SER GLY          
SEQRES  32 G  594  VAL ASP VAL THR PRO PHE TYR ILE ARG HIS ARG ILE VAL          
SEQRES  33 G  594  SER PRO ALA ASP LEU ILE LEU VAL LEU ASN ASN LEU TYR          
SEQRES  34 G  594  ARG TRP ALA THR ILE ASP GLY VAL TRP ASP PRO ARG ALA          
SEQRES  35 G  594  HIS SER VAL TYR LEU LYS TYR ARG LYS LEU LEU PRO LYS          
SEQRES  36 G  594  GLN LEU GLN ARG ASN THR ILE PRO ASP GLY TYR GLY ASP          
SEQRES  37 G  594  GLY ALA LEU VAL GLY SER VAL LEU ILE ASN PRO PHE ALA          
SEQRES  38 G  594  LYS ASN ARG GLY TRP ILE ARG TYR VAL PRO VAL ILE THR          
SEQRES  39 G  594  ASP HIS THR ARG ASP ARG GLU ARG ALA GLU LEU GLY SER          
SEQRES  40 G  594  TYR LEU TYR ASP LEU PHE SER ARG CYS LEU SER GLU SER          
SEQRES  41 G  594  ASN ASP GLY LEU PRO LEU ARG GLY PRO SER GLY CYS ASP          
SEQRES  42 G  594  SER ALA ASP LEU PHE ALA ILE ASP GLN LEU ILE CYS ARG          
SEQRES  43 G  594  SER ASN PRO THR LYS ILE SER ARG SER THR GLY LYS PHE          
SEQRES  44 G  594  ASP ILE GLN TYR ILE ALA CYS SER SER ARG VAL LEU ALA          
SEQRES  45 G  594  PRO TYR GLY VAL PHE GLN GLY THR LYS VAL ALA SER LEU          
SEQRES  46 G  594  HIS GLU ALA HIS HIS HIS HIS HIS HIS                          
SEQRES   1 H  281  MET THR GLU SER PHE ALA GLN LEU PHE GLU GLU SER LEU          
SEQRES   2 H  281  LYS GLU ILE GLU THR ARG PRO GLY SER ILE VAL ARG GLY          
SEQRES   3 H  281  VAL VAL VAL ALA ILE ASP LYS ASP VAL VAL LEU VAL ASP          
SEQRES   4 H  281  ALA GLY LEU LYS SER GLU SER ALA ILE PRO ALA GLU GLN          
SEQRES   5 H  281  PHE LYS ASN ALA GLN GLY GLU LEU GLU ILE GLN VAL GLY          
SEQRES   6 H  281  ASP GLU VAL ASP VAL ALA LEU ASP ALA VAL GLU ASP GLY          
SEQRES   7 H  281  PHE GLY GLU THR LEU LEU SER ARG GLU LYS ALA LYS ARG          
SEQRES   8 H  281  HIS GLU ALA TRP ILE THR LEU GLU LYS ALA TYR GLU ASP          
SEQRES   9 H  281  ALA GLU THR VAL THR GLY VAL ILE ASN GLY LYS VAL LYS          
SEQRES  10 H  281  GLY GLY PHE THR VAL GLU LEU ASN GLY ILE ARG ALA PHE          
SEQRES  11 H  281  LEU PRO GLY SER LEU VAL ASP VAL ARG PRO VAL ARG ASP          
SEQRES  12 H  281  THR LEU HIS LEU GLU GLY LYS GLU LEU GLU PHE LYS VAL          
SEQRES  13 H  281  ILE LYS LEU ASP GLN LYS ARG ASN ASN VAL VAL VAL SER          
SEQRES  14 H  281  ARG ARG ALA VAL ILE GLU SER GLU ASN SER ALA GLU ARG          
SEQRES  15 H  281  ASP GLN LEU LEU GLU ASN LEU GLN GLU GLY MET GLU VAL          
SEQRES  16 H  281  LYS GLY ILE VAL LYS ASN LEU THR ASP TYR GLY ALA PHE          
SEQRES  17 H  281  VAL ASP LEU GLY GLY VAL ASP GLY LEU LEU HIS ILE THR          
SEQRES  18 H  281  ASP MET ALA TRP LYS ARG VAL LYS HIS PRO SER GLU ILE          
SEQRES  19 H  281  VAL ASN VAL GLY ASP GLU ILE THR VAL LYS VAL LEU LYS          
SEQRES  20 H  281  PHE ASP ARG GLU ARG THR ARG VAL SER LEU GLY LEU LYS          
SEQRES  21 H  281  GLN LEU GLY GLU ASP PRO TRP VAL ALA ILE ALA LYS ARG          
SEQRES  22 H  281  LEU GLU HIS HIS HIS HIS HIS HIS                              
HET    SO4  C 601       5                                                       
HET    SO4  C 602       5                                                       
HET    SO4  G 601       5                                                       
HET    SO4  G 602       5                                                       
HETNAM     SO4 SULFATE ION                                                      
FORMUL   9  SO4    4(O4 S 2-)                                                   
FORMUL  13  HOH   *253(H2 O)                                                    
HELIX    1   1 THR A    4  GLY A   16  1                                  13    
HELIX    2   2 GLY A   18  ALA A   29  1                                  12    
HELIX    3   3 ASP A   32  ALA A   52  1                                  21    
HELIX    4   4 PHE A   81  LYS A   84  5                                   4    
HELIX    5   5 ASP A   85  LYS A  103  1                                  19    
HELIX    6   6 ASP A  106  PHE A  114  1                                   9    
HELIX    7   7 PHE A  114  GLY A  126  1                                  13    
HELIX    8   8 ASP A  161  LYS A  176  1                                  16    
HELIX    9   9 SER A  186  GLN A  203  1                                  18    
HELIX   10  10 PRO A  207  SER A  227  1                                  21    
HELIX   11  11 THR A  240  HIS A  248  1                                   9    
HELIX   12  12 ASP A  270  SER A  279  1                                  10    
HELIX   13  13 GLY B   23  TYR B   39  1                                  17    
HELIX   14  14 GLY B   83  THR B   93  1                                  11    
HELIX   15  15 GLN B  114  GLY B  126  1                                  13    
HELIX   16  16 ASP B  142  TYR B  160  1                                  19    
HELIX   17  17 SER B  173  GLU B  179  1                                   7    
HELIX   18  18 ASP B  181  TYR B  198  1                                  18    
HELIX   19  19 LYS B  282  ILE B  286  5                                   5    
HELIX   20  20 SER C    9  ASN C   19  1                                  11    
HELIX   21  21 ASN C   27  TYR C   40  1                                  14    
HELIX   22  22 SER C   47  PHE C   54  1                                   8    
HELIX   23  23 THR C   61  ILE C   74  1                                  14    
HELIX   24  24 GLU C   88  ARG C  111  1                                  24    
HELIX   25  25 ASN C  119  GLY C  139  1                                  21    
HELIX   26  26 SER C  143  CYS C  151  1                                   9    
HELIX   27  27 HIS C  167  LEU C  174  1                                   8    
HELIX   28  28 ALA C  182  THR C  193  1                                  12    
HELIX   29  29 PRO C  225  LEU C  243  1                                  19    
HELIX   30  30 GLN C  253  THR C  266  1                                  14    
HELIX   31  31 ALA C  276  ILE C  281  1                                   6    
HELIX   32  32 SER C  282  LEU C  290  1                                   9    
HELIX   33  33 PRO C  291  ARG C  302  1                                  12    
HELIX   34  34 TYR C  326  LEU C  346  1                                  21    
HELIX   35  35 ALA C  366  GLY C  378  1                                  13    
HELIX   36  36 SER C  417  ALA C  432  1                                  16    
HELIX   37  37 ASP C  439  ARG C  450  1                                  12    
HELIX   38  38 LYS C  451  LEU C  453  5                                   3    
HELIX   39  39 PRO C  454  ASN C  460  1                                   7    
HELIX   40  40 SER C  474  ASN C  478  5                                   5    
HELIX   41  41 ALA C  503  LEU C  517  1                                  15    
HELIX   42  42 SER C  518  SER C  520  5                                   3    
HELIX   43  43 ILE C  540  ILE C  544  5                                   5    
HELIX   44  44 SER D    4  ARG D   19  1                                  16    
HELIX   45  45 GLY D   78  LEU D   83  1                                   6    
HELIX   46  46 LEU D   84  TYR D  102  1                                  19    
HELIX   47  47 ARG D  142  HIS D  146  5                                   5    
HELIX   48  48 ARG D  170  SER D  176  1                                   7    
HELIX   49  49 SER E    6  THR E   15  1                                  10    
HELIX   50  50 GLY E   18  ALA E   29  1                                  12    
HELIX   51  51 ASP E   32  ALA E   52  1                                  21    
HELIX   52  52 THR E   79  LYS E   84  1                                   6    
HELIX   53  53 ASP E   85  GLY E  102  1                                  18    
HELIX   54  54 ASP E  106  PHE E  114  1                                   9    
HELIX   55  55 PHE E  114  GLY E  126  1                                  13    
HELIX   56  56 ASP E  161  LYS E  176  1                                  16    
HELIX   57  57 LYS E  181  VAL E  185  5                                   5    
HELIX   58  58 SER E  186  GLN E  203  1                                  18    
HELIX   59  59 PRO E  207  VAL E  226  1                                  20    
HELIX   60  60 THR E  240  HIS E  248  1                                   9    
HELIX   61  61 ASP E  270  SER E  279  1                                  10    
HELIX   62  62 LYS E  280  SER E  282  5                                   3    
HELIX   63  63 VAL F   20  HIS F   22  5                                   3    
HELIX   64  64 GLY F   23  TYR F   39  1                                  17    
HELIX   65  65 GLY F   83  THR F   93  1                                  11    
HELIX   66  66 MET F  112  GLY F  126  1                                  15    
HELIX   67  67 CYS F  137  VAL F  140  5                                   4    
HELIX   68  68 ASP F  142  TYR F  160  1                                  19    
HELIX   69  69 SER F  173  GLU F  179  1                                   7    
HELIX   70  70 ASP F  181  TYR F  198  1                                  18    
HELIX   71  71 LYS F  282  ILE F  286  5                                   5    
HELIX   72  72 SER G    9  ASN G   19  1                                  11    
HELIX   73  73 ASN G   27  GLY G   41  1                                  15    
HELIX   74  74 SER G   47  PHE G   54  1                                   8    
HELIX   75  75 THR G   61  MET G   75  1                                  15    
HELIX   76  76 GLU G   88  ARG G  111  1                                  24    
HELIX   77  77 ASN G  119  GLY G  139  1                                  21    
HELIX   78  78 SER G  143  CYS G  151  1                                   9    
HELIX   79  79 HIS G  167  LEU G  174  1                                   8    
HELIX   80  80 ALA G  182  SER G  192  1                                  11    
HELIX   81  81 PRO G  225  LEU G  243  1                                  19    
HELIX   82  82 ARG G  244  GLY G  247  5                                   4    
HELIX   83  83 GLN G  253  SER G  264  1                                  12    
HELIX   84  84 ALA G  276  SER G  280  5                                   5    
HELIX   85  85 SER G  282  LEU G  290  1                                   9    
HELIX   86  86 PRO G  291  ARG G  302  1                                  12    
HELIX   87  87 TYR G  326  LEU G  346  1                                  21    
HELIX   88  88 ASP G  349  VAL G  353  5                                   5    
HELIX   89  89 ALA G  366  GLY G  378  1                                  13    
HELIX   90  90 SER G  417  THR G  433  1                                  17    
HELIX   91  91 ASP G  439  ARG G  450  1                                  12    
HELIX   92  92 LYS G  451  LEU G  453  5                                   3    
HELIX   93  93 PRO G  454  ARG G  459  1                                   6    
HELIX   94  94 SER G  474  ASN G  478  5                                   5    
HELIX   95  95 ALA G  503  GLU G  519  1                                  17    
HELIX   96  96 ASP G  541  CYS G  545  5                                   5    
HELIX   97  97 GLU H    3  ARG H   19  1                                  17    
HELIX   98  98 GLU H   87  ASP H  104  1                                  18    
SHEET    1   A 3 GLY A  59  ASP A  66  0                                        
SHEET    2   A 3 TYR A  69  ASN A  76 -1  O  TYR A  69   N  ASP A  66           
SHEET    3   A 3 ASN A 130  GLU A 138 -1  O  ALA A 135   N  ILE A  72           
SHEET    1   B 3 VAL A 141  HIS A 147  0                                        
SHEET    2   B 3 ILE A 151  LYS A 158 -1  O  ALA A 157   N  VAL A 141           
SHEET    3   B 3 GLU A 251  GLU A 259 -1  O  PHE A 258   N  GLY A 152           
SHEET    1   C 6 VAL B  67  ASP B  70  0                                        
SHEET    2   C 6 HIS B  75  ASP B  80 -1  O  HIS B  78   N  VAL B  67           
SHEET    3   C 6 HIS B  11  GLY B  18  1  N  VAL B  12   O  HIS B  75           
SHEET    4   C 6 GLY B 100  ALA B 106  1  O  VAL B 104   N  ILE B  17           
SHEET    5   C 6 TYR B 129  ASN B 135  1  O  ILE B 131   N  LEU B 103           
SHEET    6   C 6 ILE B 169  GLY B 172  1  O  VAL B 170   N  VAL B 132           
SHEET    1   D 7 LEU B 211  PRO B 213  0                                        
SHEET    2   D 7 VAL B 291  ALA B 293 -1  O  LEU B 292   N  LEU B 212           
SHEET    3   D 7 GLU B 241  VAL B 245 -1  N  VAL B 245   O  VAL B 291           
SHEET    4   D 7 GLN B 251  GLU B 259 -1  O  SER B 253   N  VAL B 242           
SHEET    5   D 7 ASN B 273  ARG B 279 -1  O  LEU B 277   N  GLY B 257           
SHEET    6   D 7 GLY B 224  ARG B 230 -1  N  THR B 225   O  LEU B 278           
SHEET    7   D 7 ASP B 216  ILE B 220 -1  N  PHE B 218   O  VAL B 226           
SHEET    1   E 5 LEU B 211  PRO B 213  0                                        
SHEET    2   E 5 VAL B 291  ALA B 293 -1  O  LEU B 292   N  LEU B 212           
SHEET    3   E 5 GLU B 241  VAL B 245 -1  N  VAL B 245   O  VAL B 291           
SHEET    4   E 5 GLN B 251  GLU B 259 -1  O  SER B 253   N  VAL B 242           
SHEET    5   E 5 LEU B 264  LEU B 265 -1  O  LEU B 265   N  VAL B 258           
SHEET    1   F 7 LYS B 299  ILE B 310  0                                        
SHEET    2   F 7 ASN B 355  MET B 368 -1  O  MET B 358   N  SER B 306           
SHEET    3   F 7 THR B 335  GLU B 342 -1  N  THR B 340   O  THR B 361           
SHEET    4   F 7 GLN B 329  PHE B 332 -1  N  PHE B 330   O  VAL B 337           
SHEET    5   F 7 ARG B 373  GLU B 378 -1  O  ARG B 377   N  GLN B 329           
SHEET    6   F 7 ARG B 381  VAL B 391 -1  O  GLY B 384   N  ILE B 376           
SHEET    7   F 7 LYS B 299  ILE B 310 -1  N  TYR B 309   O  ALA B 385           
SHEET    1   G 2 GLN C 176  CYS C 178  0                                        
SHEET    2   G 2 ILE C 199  ILE C 202  1  O  ASP C 201   N  CYS C 178           
SHEET    1   H 2 LYS C 207  VAL C 211  0                                        
SHEET    2   H 2 ARG C 219  ILE C 223 -1  O  ILE C 221   N  VAL C 209           
SHEET    1   I 3 LEU C 269  VAL C 272  0                                        
SHEET    2   I 3 ASP C 359  PRO C 363 -1  O  ILE C 360   N  VAL C 272           
SHEET    3   I 3 THR C 354  TYR C 356 -1  N  TYR C 356   O  ASP C 359           
SHEET    1   J 2 LYS C 305  ARG C 307  0                                        
SHEET    2   J 2 VAL C 313  THR C 315 -1  O  VAL C 314   N  GLY C 306           
SHEET    1   K 3 PHE C 392  SER C 395  0                                        
SHEET    2   K 3 LYS C 398  TYR C 401 -1  O  TYR C 400   N  ARG C 393           
SHEET    3   K 3 VAL C 404  ASP C 405 -1  O  VAL C 404   N  TYR C 401           
SHEET    1   L 2 THR C 433  ILE C 434  0                                        
SHEET    2   L 2 VAL C 437  TRP C 438 -1  O  VAL C 437   N  ILE C 434           
SHEET    1   M 2 THR C 461  ILE C 462  0                                        
SHEET    2   M 2 LEU C 471  VAL C 472  1  O  LEU C 471   N  ILE C 462           
SHEET    1   N 3 LYS C 482  ARG C 484  0                                        
SHEET    2   N 3 ILE C 487  ASP C 499 -1  O  TYR C 489   N  LYS C 482           
SHEET    3   N 3 SER C 553  CYS C 566 -1  O  THR C 556   N  HIS C 496           
SHEET    1   O 4 SER D  46  ILE D  48  0                                        
SHEET    2   O 4 VAL D  36  ASP D  39 -1  N  VAL D  38   O  SER D  46           
SHEET    3   O 4 ILE D  23  ILE D  31 -1  N  VAL D  27   O  ASP D  39           
SHEET    4   O 4 GLU D  67  ALA D  71 -1  O  VAL D  70   N  VAL D  24           
SHEET    1   P 6 THR D 107  LYS D 115  0                                        
SHEET    2   P 6 GLY D 119  LEU D 124 -1  O  GLU D 123   N  VAL D 111           
SHEET    3   P 6 ILE D 127  PRO D 132 -1  O  LEU D 131   N  PHE D 120           
SHEET    4   P 6 VAL D 166  SER D 169  1  O  VAL D 166   N  PHE D 130           
SHEET    5   P 6 GLU D 151  LEU D 159 -1  N  LYS D 155   O  SER D 169           
SHEET    6   P 6 THR D 107  LYS D 115 -1  N  VAL D 108   O  PHE D 154           
SHEET    1   Q 3 GLY E  59  ASP E  66  0                                        
SHEET    2   Q 3 TYR E  69  ASN E  76 -1  O  LEU E  73   N  LYS E  62           
SHEET    3   Q 3 ASN E 130  GLU E 138 -1  O  ALA E 135   N  ILE E  72           
SHEET    1   R 3 VAL E 141  HIS E 147  0                                        
SHEET    2   R 3 ILE E 151  LYS E 158 -1  O  ALA E 157   N  VAL E 141           
SHEET    3   R 3 GLU E 251  GLU E 259 -1  O  GLY E 254   N  ALA E 156           
SHEET    1   S 6 VAL F  67  THR F  71  0                                        
SHEET    2   S 6 ARG F  74  ASP F  80 -1  O  HIS F  78   N  VAL F  67           
SHEET    3   S 6 HIS F  11  GLY F  18  1  N  VAL F  12   O  HIS F  75           
SHEET    4   S 6 GLY F 100  ALA F 106  1  O  ILE F 102   N  GLY F  15           
SHEET    5   S 6 ILE F 130  ASN F 135  1  O  ILE F 131   N  LEU F 103           
SHEET    6   S 6 ILE F 169  GLY F 172  1  O  GLY F 172   N  LEU F 134           
SHEET    1   T 7 LEU F 211  PRO F 213  0                                        
SHEET    2   T 7 VAL F 291  ALA F 293 -1  O  LEU F 292   N  LEU F 212           
SHEET    3   T 7 GLU F 241  VAL F 245 -1  N  VAL F 245   O  VAL F 291           
SHEET    4   T 7 GLN F 251  GLU F 259 -1  O  SER F 253   N  VAL F 242           
SHEET    5   T 7 ASN F 273  ARG F 279 -1  O  LEU F 277   N  GLY F 257           
SHEET    6   T 7 GLY F 224  ARG F 230 -1  N  THR F 225   O  LEU F 278           
SHEET    7   T 7 ASP F 216  ILE F 220 -1  N  PHE F 218   O  VAL F 226           
SHEET    1   U 5 LEU F 211  PRO F 213  0                                        
SHEET    2   U 5 VAL F 291  ALA F 293 -1  O  LEU F 292   N  LEU F 212           
SHEET    3   U 5 GLU F 241  VAL F 245 -1  N  VAL F 245   O  VAL F 291           
SHEET    4   U 5 GLN F 251  GLU F 259 -1  O  SER F 253   N  VAL F 242           
SHEET    5   U 5 LEU F 264  LEU F 265 -1  O  LEU F 265   N  VAL F 258           
SHEET    1   V 2 ILE F 235  LYS F 237  0                                        
SHEET    2   V 2 GLU F 267  ARG F 269 -1  O  GLY F 268   N  ILE F 236           
SHEET    1   W 7 LYS F 299  ILE F 310  0                                        
SHEET    2   W 7 ASN F 355  MET F 368 -1  O  ILE F 366   N  HIS F 301           
SHEET    3   W 7 THR F 335  GLU F 342 -1  N  THR F 340   O  THR F 361           
SHEET    4   W 7 GLN F 329  PHE F 332 -1  N  PHE F 330   O  VAL F 337           
SHEET    5   W 7 ARG F 373  GLU F 378 -1  O  ARG F 377   N  GLN F 329           
SHEET    6   W 7 ARG F 381  VAL F 391 -1  O  GLY F 386   N  PHE F 374           
SHEET    7   W 7 LYS F 299  ILE F 310 -1  N  GLU F 305   O  LYS F 390           
SHEET    1   X 2 LYS G 207  PRO G 212  0                                        
SHEET    2   X 2 ASP G 218  ILE G 223 -1  O  ARG G 219   N  VAL G 211           
SHEET    1   Y 3 LEU G 269  ASP G 273  0                                        
SHEET    2   Y 3 ASP G 359  PRO G 363 -1  O  ILE G 360   N  VAL G 272           
SHEET    3   Y 3 THR G 354  TYR G 356 -1  N  TYR G 356   O  ASP G 359           
SHEET    1   Z 2 LYS G 305  ARG G 307  0                                        
SHEET    2   Z 2 VAL G 313  THR G 315 -1  O  VAL G 314   N  GLY G 306           
SHEET    1  AA 3 PHE G 392  SER G 395  0                                        
SHEET    2  AA 3 LYS G 398  TYR G 401 -1  O  TYR G 400   N  ARG G 393           
SHEET    3  AA 3 VAL G 404  ASP G 405 -1  O  VAL G 404   N  TYR G 401           
SHEET    1  AB 2 THR G 461  ILE G 462  0                                        
SHEET    2  AB 2 LEU G 471  VAL G 472  1  O  LEU G 471   N  ILE G 462           
SHEET    1  AC 3 LYS G 482  ASN G 483  0                                        
SHEET    2  AC 3 ARG G 488  ARG G 500 -1  O  TYR G 489   N  LYS G 482           
SHEET    3  AC 3 ILE G 552  ALA G 565 -1  O  ILE G 552   N  ARG G 500           
SHEET    1  AD 2 ILE H  23  VAL H  24  0                                        
SHEET    2  AD 2 VAL H  70  ALA H  71 -1  O  VAL H  70   N  VAL H  24           
SHEET    1  AE 3 VAL H  27  ILE H  31  0                                        
SHEET    2  AE 3 VAL H  36  ASP H  39 -1  O  ASP H  39   N  VAL H  27           
SHEET    3  AE 3 SER H  46  ILE H  48 -1  O  SER H  46   N  VAL H  38           
SHEET    1  AF 6 VAL H 108  LYS H 115  0                                        
SHEET    2  AF 6 GLY H 119  GLU H 123 -1  O  GLU H 123   N  VAL H 111           
SHEET    3  AF 6 ARG H 128  PRO H 132 -1  O  ALA H 129   N  VAL H 122           
SHEET    4  AF 6 VAL H 166  SER H 169  1  O  VAL H 168   N  PHE H 130           
SHEET    5  AF 6 LEU H 152  LEU H 159 -1  N  ILE H 157   O  VAL H 167           
SHEET    6  AF 6 VAL H 108  LYS H 115 -1  N  GLY H 110   O  LEU H 152           
SITE     1 AC1  4 SER B 219  SER B 221  GLU C 504  LEU C 505                    
SITE     1 AC2  5 HIS B 319  THR B 320  SER C 567  SER C 568                    
SITE     2 AC2  5 HOH C 761                                                     
SITE     1 AC3  4 SER F 219  SER F 221  GLU G 504  LEU G 505                    
SITE     1 AC4  6 HIS F 319  THR F 320  CYS G 566  SER G 567                    
SITE     2 AC4  6 SER G 568  HOH G 751                                          
CRYST1  132.190  150.830  189.780  90.00  90.00  90.00 P 21 21 21    8          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.007565  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.006630  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.005269        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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