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Database: PDB
Entry: 4S3O
LinkDB: 4S3O
Original site: 4S3O 
HEADER    LIGASE/TRANSCRIPTION                    23-MAR-15   4S3O              
TITLE     PCGF5-RING1B-UBCH5C COMPLEX                                           
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: UBIQUITIN-CONJUGATING ENZYME E2 D3;                        
COMPND   3 CHAIN: A, D;                                                         
COMPND   4 SYNONYM: UBIQUITIN CARRIER PROTEIN D3, UBIQUITIN-CONJUGATING ENZYME  
COMPND   5 E2(17)KB 3, UBIQUITIN-CONJUGATING ENZYME E2-17 KDA 3, UBIQUITIN-     
COMPND   6 PROTEIN LIGASE D3;                                                   
COMPND   7 EC: 6.3.2.19;                                                        
COMPND   8 ENGINEERED: YES;                                                     
COMPND   9 MOL_ID: 2;                                                           
COMPND  10 MOLECULE: E3 UBIQUITIN-PROTEIN LIGASE RING2;                         
COMPND  11 CHAIN: B, E;                                                         
COMPND  12 FRAGMENT: RING DOMAIN, UNP RESIDUES 1-116;                           
COMPND  13 SYNONYM: HUNTINGTIN-INTERACTING PROTEIN 2-INTERACTING PROTEIN 3,     
COMPND  14 HIP2-INTERACTING PROTEIN 3, PROTEIN DING, RING FINGER PROTEIN 1B,    
COMPND  15 RING1B, RING FINGER PROTEIN 2, RING FINGER PROTEIN BAP-1;            
COMPND  16 EC: 6.3.2.-;                                                         
COMPND  17 ENGINEERED: YES;                                                     
COMPND  18 MOL_ID: 3;                                                           
COMPND  19 MOLECULE: POLYCOMB GROUP RING FINGER PROTEIN 5;                      
COMPND  20 CHAIN: C, F;                                                         
COMPND  21 FRAGMENT: RING DOMAIN, UNP RESIDUES 1-109;                           
COMPND  22 SYNONYM: RING FINGER PROTEIN 159;                                    
COMPND  23 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: UBE2D3, UBC5C, UBCH5C;                                         
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: RNF2, BAP1, DING, HIPI3, RING1B;                               
SOURCE  13 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  17 ORGANISM_COMMON: HUMAN;                                              
SOURCE  18 ORGANISM_TAXID: 9606;                                                
SOURCE  19 GENE: PCGF5, RNF159;                                                 
SOURCE  20 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  21 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    E2, E3, RING DOMAIN, UBIQUITIN RING E3 LIGASE, LIGASE-TRANSCRIPTION   
KEYWDS   2 COMPLEX                                                              
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    A.M.TAHERBHOY,A.G.COCHRAN                                             
REVDAT   2   22-JUL-15 4S3O    1       JRNL                                     
REVDAT   1   15-JUL-15 4S3O    0                                                
JRNL        AUTH   A.M.TAHERBHOY,O.W.HUANG,A.G.COCHRAN                          
JRNL        TITL   BMI1-RING1B IS AN AUTOINHIBITED RING E3 UBIQUITIN LIGASE.    
JRNL        REF    NAT COMMUN                    V.   6  7621 2015              
JRNL        REFN                   ESSN 2041-1723                               
JRNL        PMID   26151332                                                     
JRNL        DOI    10.1038/NCOMMS8621                                           
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.00 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE: 1.8.2_1309)                   
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-                     
REMARK   3               : KUNSTLEVE,LI-WEI HUNG,ROBERT IMMORMINO,              
REMARK   3               : TOM IOERGER,AIRLIE MCCOY,ERIK MCKEE,NIGEL            
REMARK   3               : MORIARTY,REETAL PAI,RANDY READ,JANE                  
REMARK   3               : RICHARDSON,DAVID RICHARDSON,TOD ROMO,JIM             
REMARK   3               : SACCHETTINI,NICHOLAS SAUTER,JACOB SMITH,             
REMARK   3               : LAURENT STORONI,TOM TERWILLIGER,PETER                
REMARK   3               : ZWART                                                
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.00                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 48.92                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.340                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.8                           
REMARK   3   NUMBER OF REFLECTIONS             : 52191                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.196                           
REMARK   3   R VALUE            (WORKING SET) : 0.194                           
REMARK   3   FREE R VALUE                     : 0.237                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.100                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 2664                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 48.9332 -  5.3328    0.99     2799   156  0.1667 0.1926        
REMARK   3     2  5.3328 -  4.2336    1.00     2674   138  0.1469 0.2117        
REMARK   3     3  4.2336 -  3.6986    1.00     2666   142  0.1647 0.1736        
REMARK   3     4  3.6986 -  3.3605    1.00     2619   147  0.1893 0.2237        
REMARK   3     5  3.3605 -  3.1197    1.00     2637   134  0.2225 0.2602        
REMARK   3     6  3.1197 -  2.9358    1.00     2611   142  0.2357 0.2633        
REMARK   3     7  2.9358 -  2.7888    1.00     2640   131  0.2344 0.3313        
REMARK   3     8  2.7888 -  2.6674    1.00     2568   165  0.2284 0.2832        
REMARK   3     9  2.6674 -  2.5647    1.00     2520   166  0.2308 0.2726        
REMARK   3    10  2.5647 -  2.4762    1.00     2606   133  0.2139 0.2691        
REMARK   3    11  2.4762 -  2.3988    1.00     2615   116  0.2088 0.2476        
REMARK   3    12  2.3988 -  2.3302    1.00     2600   131  0.2038 0.2809        
REMARK   3    13  2.3302 -  2.2689    1.00     2551   155  0.2150 0.2597        
REMARK   3    14  2.2689 -  2.2135    1.00     2602   131  0.2053 0.2595        
REMARK   3    15  2.2135 -  2.1632    1.00     2554   130  0.2123 0.2528        
REMARK   3    16  2.1632 -  2.1172    1.00     2578   126  0.2071 0.2767        
REMARK   3    17  2.1172 -  2.0748    1.00     2576   134  0.2226 0.2861        
REMARK   3    18  2.0748 -  2.0357    1.00     2580   136  0.2326 0.2813        
REMARK   3    19  2.0357 -  2.0000    0.99     2531   151  0.2426 0.2933        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.230            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 25.130           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 32.06                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.009           5650                                  
REMARK   3   ANGLE     :  1.143           7712                                  
REMARK   3   CHIRALITY :  0.076            870                                  
REMARK   3   PLANARITY :  0.006            990                                  
REMARK   3   DIHEDRAL  : 13.071           2096                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 41                                         
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: chain 'A' and (resid 0 through 25 )                    
REMARK   3    ORIGIN FOR THE GROUP (A):   5.6566   0.0865 -17.4949              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3830 T22:   0.2389                                     
REMARK   3      T33:   0.3282 T12:   0.0033                                     
REMARK   3      T13:   0.0712 T23:  -0.1157                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   9.7337 L22:   5.5421                                     
REMARK   3      L33:   8.1646 L12:  -5.0267                                     
REMARK   3      L13:   4.4614 L23:  -6.1229                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1055 S12:   0.3423 S13:   0.4706                       
REMARK   3      S21:  -0.1451 S22:  -0.3026 S23:   0.0853                       
REMARK   3      S31:  -0.1602 S32:   0.1435 S33:   0.2344                       
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: chain 'A' and (resid 26 through 74 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):   0.8055 -12.0014 -17.5484              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3220 T22:   0.1779                                     
REMARK   3      T33:   0.3391 T12:   0.0209                                     
REMARK   3      T13:   0.0377 T23:  -0.0509                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.9719 L22:   4.2924                                     
REMARK   3      L33:   4.6890 L12:   3.4880                                     
REMARK   3      L13:   2.5015 L23:   3.4109                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0963 S12:  -0.1105 S13:  -0.1536                       
REMARK   3      S21:   0.0739 S22:  -0.3568 S23:   0.5361                       
REMARK   3      S31:  -0.0780 S32:  -0.4721 S33:   0.4254                       
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: chain 'A' and (resid 75 through 111 )                  
REMARK   3    ORIGIN FOR THE GROUP (A):   7.0476 -15.5369 -23.8599              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2524 T22:   0.2046                                     
REMARK   3      T33:   0.2886 T12:   0.0182                                     
REMARK   3      T13:   0.0687 T23:  -0.0829                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.1818 L22:   5.2009                                     
REMARK   3      L33:   2.4207 L12:   5.6690                                     
REMARK   3      L13:   0.9017 L23:   0.4044                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1306 S12:   0.2835 S13:  -0.4936                       
REMARK   3      S21:  -0.1930 S22:   0.1557 S23:  -0.1665                       
REMARK   3      S31:   0.0286 S32:   0.0650 S33:  -0.0155                       
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: chain 'A' and (resid 112 through 147 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  -3.9387 -25.7376 -31.3601              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4009 T22:   0.5994                                     
REMARK   3      T33:   0.6183 T12:  -0.0520                                     
REMARK   3      T13:   0.0581 T23:  -0.3401                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.2706 L22:   6.0542                                     
REMARK   3      L33:   5.5413 L12:   1.1744                                     
REMARK   3      L13:  -0.1440 L23:   2.7063                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1496 S12:   0.9280 S13:  -0.6646                       
REMARK   3      S21:   0.0254 S22:  -0.4261 S23:   0.7234                       
REMARK   3      S31:   0.3163 S32:  -0.4479 S33:   0.3939                       
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: chain 'D' and (resid 0 through 15 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): -16.8260 -46.7444 -18.3712              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3496 T22:   0.4065                                     
REMARK   3      T33:   0.2845 T12:   0.0252                                     
REMARK   3      T13:  -0.0175 T23:   0.0493                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.6522 L22:   7.4594                                     
REMARK   3      L33:   5.0867 L12:  -0.5378                                     
REMARK   3      L13:  -0.8384 L23:   0.7153                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0272 S12:   0.1999 S13:  -0.5149                       
REMARK   3      S21:  -0.5732 S22:   0.1776 S23:   0.8502                       
REMARK   3      S31:  -0.2673 S32:  -0.4583 S33:  -0.0752                       
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: chain 'D' and (resid 16 through 28 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -11.9736 -37.0951 -13.0889              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3228 T22:   0.4692                                     
REMARK   3      T33:   0.4241 T12:   0.0465                                     
REMARK   3      T13:   0.0793 T23:   0.0058                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.6054 L22:   7.1596                                     
REMARK   3      L33:   5.5741 L12:   1.8868                                     
REMARK   3      L13:  -0.4243 L23:  -0.7544                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.6695 S12:  -0.1515 S13:   0.7989                       
REMARK   3      S21:   0.5030 S22:  -0.1754 S23:   0.4070                       
REMARK   3      S31:  -0.7978 S32:   0.3864 S33:  -0.1384                       
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: chain 'D' and (resid 29 through 38 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  -7.8059 -37.9335 -19.5457              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2788 T22:   0.3267                                     
REMARK   3      T33:   0.3423 T12:   0.0622                                     
REMARK   3      T13:  -0.0175 T23:   0.0938                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.8472 L22:   7.4835                                     
REMARK   3      L33:   7.7662 L12:   4.7121                                     
REMARK   3      L13:   3.5590 L23:   3.8792                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3334 S12:   0.5025 S13:   0.8583                       
REMARK   3      S21:   0.0150 S22:  -0.2398 S23:   0.6388                       
REMARK   3      S31:  -0.2126 S32:  -0.7511 S33:   0.3054                       
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    SELECTION: chain 'D' and (resid 39 through 84 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):   0.7619 -38.8351 -13.0468              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2578 T22:   0.2697                                     
REMARK   3      T33:   0.2585 T12:   0.0915                                     
REMARK   3      T13:   0.0195 T23:  -0.0180                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.3046 L22:   6.6633                                     
REMARK   3      L33:   4.3430 L12:   4.6708                                     
REMARK   3      L13:   1.9777 L23:   3.1796                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1025 S12:   0.0450 S13:  -0.2154                       
REMARK   3      S21:   0.2454 S22:   0.1958 S23:  -0.4423                       
REMARK   3      S31:   0.1132 S32:   0.3344 S33:  -0.2787                       
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    SELECTION: chain 'D' and (resid 85 through 111 )                  
REMARK   3    ORIGIN FOR THE GROUP (A):  -2.1143 -47.1283  -9.2163              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4361 T22:   0.3258                                     
REMARK   3      T33:   0.3488 T12:   0.0737                                     
REMARK   3      T13:  -0.0765 T23:   0.0338                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.1631 L22:   5.7560                                     
REMARK   3      L33:   3.9384 L12:   3.4793                                     
REMARK   3      L13:   3.2610 L23:  -0.2069                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.6984 S12:  -0.1970 S13:  -0.6910                       
REMARK   3      S21:   0.8029 S22:  -0.2041 S23:  -0.4900                       
REMARK   3      S31:   0.5927 S32:   0.1926 S33:  -0.4558                       
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    SELECTION: chain 'D' and (resid 112 through 120 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  10.7866 -43.4776  -3.8567              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.7990 T22:   0.8090                                     
REMARK   3      T33:   0.7869 T12:   0.1772                                     
REMARK   3      T13:  -0.3623 T23:  -0.2118                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.2606 L22:   3.8116                                     
REMARK   3      L33:   1.2989 L12:   1.9933                                     
REMARK   3      L13:  -1.1684 L23:  -0.9310                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4638 S12:  -0.0704 S13:  -1.7921                       
REMARK   3      S21:   0.3649 S22:   0.0710 S23:  -1.4916                       
REMARK   3      S31:   1.5357 S32:   0.5410 S33:  -0.6493                       
REMARK   3   TLS GROUP : 11                                                     
REMARK   3    SELECTION: chain 'D' and (resid 121 through 147 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  11.0844 -30.2584  -2.2171              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5686 T22:   0.6564                                     
REMARK   3      T33:   0.6294 T12:   0.0303                                     
REMARK   3      T13:  -0.1811 T23:  -0.2437                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.9765 L22:   6.0247                                     
REMARK   3      L33:   5.0880 L12:  -0.5171                                     
REMARK   3      L13:   3.8670 L23:  -2.2665                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2304 S12:  -0.6567 S13:  -0.0236                       
REMARK   3      S21:   1.2194 S22:   0.2144 S23:  -1.1296                       
REMARK   3      S31:  -0.3408 S32:   0.6168 S33:  -0.3280                       
REMARK   3   TLS GROUP : 12                                                     
REMARK   3    SELECTION: chain 'B' and (resid 10 through 16 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  30.3419  -4.0324 -46.3003              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4029 T22:   0.4496                                     
REMARK   3      T33:   0.2589 T12:  -0.1125                                     
REMARK   3      T13:  -0.0382 T23:   0.0157                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.1564 L22:   5.1053                                     
REMARK   3      L33:   9.2050 L12:   3.8816                                     
REMARK   3      L13:   5.2788 L23:   6.8190                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4250 S12:  -1.4386 S13:  -0.0138                       
REMARK   3      S21:  -0.0662 S22:  -0.2931 S23:   0.2943                       
REMARK   3      S31:   0.8551 S32:  -0.6712 S33:  -0.1341                       
REMARK   3   TLS GROUP : 13                                                     
REMARK   3    SELECTION: chain 'B' and (resid 17 through 41 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  28.7486  17.6169 -42.4183              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3117 T22:   0.5222                                     
REMARK   3      T33:   0.4635 T12:  -0.1875                                     
REMARK   3      T13:  -0.0709 T23:   0.0246                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.4275 L22:   4.2021                                     
REMARK   3      L33:   5.9862 L12:  -1.7573                                     
REMARK   3      L13:  -1.6842 L23:   1.4381                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0955 S12:   0.2552 S13:   0.3863                       
REMARK   3      S21:  -0.5494 S22:   0.1728 S23:   0.1220                       
REMARK   3      S31:  -0.6552 S32:  -0.0976 S33:  -0.3089                       
REMARK   3   TLS GROUP : 14                                                     
REMARK   3    SELECTION: chain 'B' and (resid 42 through 49 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  15.5974  12.4382 -25.3123              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3259 T22:   0.3980                                     
REMARK   3      T33:   0.4019 T12:  -0.0621                                     
REMARK   3      T13:  -0.0138 T23:  -0.0111                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.4903 L22:   2.2633                                     
REMARK   3      L33:   6.9086 L12:  -2.9911                                     
REMARK   3      L13:  -0.2554 L23:   2.3871                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1775 S12:   0.3557 S13:  -0.5606                       
REMARK   3      S21:  -0.2957 S22:  -0.2037 S23:   1.4933                       
REMARK   3      S31:   0.2873 S32:  -0.7220 S33:   0.0113                       
REMARK   3   TLS GROUP : 15                                                     
REMARK   3    SELECTION: chain 'B' and (resid 50 through 60 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  20.1025   4.4325 -17.9741              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2035 T22:   0.2533                                     
REMARK   3      T33:   0.2141 T12:  -0.0005                                     
REMARK   3      T13:   0.0054 T23:  -0.0481                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.0383 L22:   9.6262                                     
REMARK   3      L33:   6.7957 L12:   2.7282                                     
REMARK   3      L13:  -4.4948 L23:  -4.9861                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1322 S12:  -0.4085 S13:   0.4991                       
REMARK   3      S21:   0.6154 S22:  -0.0121 S23:   0.0422                       
REMARK   3      S31:  -0.1412 S32:   0.1673 S33:  -0.0981                       
REMARK   3   TLS GROUP : 16                                                     
REMARK   3    SELECTION: chain 'B' and (resid 61 through 69 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  29.4875  -0.4958 -26.9276              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2629 T22:   0.2832                                     
REMARK   3      T33:   0.2989 T12:   0.0058                                     
REMARK   3      T13:   0.0189 T23:  -0.0181                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   6.4211 L22:   8.5097                                     
REMARK   3      L33:   9.1471 L12:   1.5085                                     
REMARK   3      L13:   1.6371 L23:   5.2744                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1624 S12:  -0.0975 S13:  -0.1199                       
REMARK   3      S21:   0.0673 S22:  -0.0970 S23:  -0.4213                       
REMARK   3      S31:   0.4623 S32:   0.1920 S33:  -0.0119                       
REMARK   3   TLS GROUP : 17                                                     
REMARK   3    SELECTION: chain 'B' and (resid 70 through 81 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  26.2228  -2.9235 -16.7939              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3127 T22:   0.4301                                     
REMARK   3      T33:   0.3167 T12:   0.0620                                     
REMARK   3      T13:  -0.0284 T23:   0.0408                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.7907 L22:   3.4151                                     
REMARK   3      L33:   7.4361 L12:  -1.4989                                     
REMARK   3      L13:   0.8540 L23:  -4.7263                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1061 S12:  -1.0578 S13:  -0.5077                       
REMARK   3      S21:   0.0303 S22:   0.0384 S23:  -0.2311                       
REMARK   3      S31:   0.4513 S32:   0.9764 S33:   0.1161                       
REMARK   3   TLS GROUP : 18                                                     
REMARK   3    SELECTION: chain 'B' and (resid 82 through 96 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  25.4770  -9.8631 -24.9753              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5152 T22:   0.2837                                     
REMARK   3      T33:   0.6649 T12:   0.0018                                     
REMARK   3      T13:   0.1728 T23:  -0.0300                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.6963 L22:   5.0664                                     
REMARK   3      L33:   8.2638 L12:  -2.7863                                     
REMARK   3      L13:   4.3077 L23:   0.8886                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1904 S12:   0.1513 S13:  -1.8955                       
REMARK   3      S21:   0.0820 S22:   0.1087 S23:  -0.1470                       
REMARK   3      S31:   0.4638 S32:  -0.0184 S33:   0.0783                       
REMARK   3   TLS GROUP : 19                                                     
REMARK   3    SELECTION: chain 'B' and (resid 97 through 103 )                  
REMARK   3    ORIGIN FOR THE GROUP (A):  34.5466  -0.1714 -22.6569              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3260 T22:   0.5317                                     
REMARK   3      T33:   0.4885 T12:  -0.0026                                     
REMARK   3      T13:   0.0646 T23:  -0.0053                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.0622 L22:   4.1196                                     
REMARK   3      L33:   6.4227 L12:  -5.7250                                     
REMARK   3      L13:   1.9385 L23:  -0.8665                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0526 S12:  -0.1293 S13:  -0.2148                       
REMARK   3      S21:   0.2887 S22:  -0.2403 S23:  -0.8782                       
REMARK   3      S31:   0.0922 S32:   1.0643 S33:   0.2760                       
REMARK   3   TLS GROUP : 20                                                     
REMARK   3    SELECTION: chain 'B' and (resid 104 through 116 )                 
REMARK   3    ORIGIN FOR THE GROUP (A):  26.1138  15.4650 -20.7305              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2635 T22:   0.3891                                     
REMARK   3      T33:   0.3355 T12:  -0.0986                                     
REMARK   3      T13:   0.0098 T23:  -0.0852                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.4255 L22:   7.1810                                     
REMARK   3      L33:   6.5126 L12:  -3.8975                                     
REMARK   3      L13:  -2.8519 L23:   0.7069                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.4643 S12:  -0.6282 S13:   1.1289                       
REMARK   3      S21:  -0.3567 S22:   0.1215 S23:  -0.7516                       
REMARK   3      S31:  -0.6748 S32:   0.6835 S33:  -0.4758                       
REMARK   3   TLS GROUP : 21                                                     
REMARK   3    SELECTION: chain 'E' and (resid 10 through 16 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  -9.2387 -68.0572  12.9778              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2589 T22:   0.3119                                     
REMARK   3      T33:   0.2653 T12:   0.0678                                     
REMARK   3      T13:  -0.0217 T23:  -0.0726                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.6741 L22:   9.4166                                     
REMARK   3      L33:   6.9063 L12:   2.8496                                     
REMARK   3      L13:   4.9148 L23:   2.5187                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2752 S12:   0.0547 S13:  -0.1595                       
REMARK   3      S21:   0.1106 S22:   0.2706 S23:  -0.0272                       
REMARK   3      S31:  -0.0634 S32:   0.6005 S33:  -0.0463                       
REMARK   3   TLS GROUP : 22                                                     
REMARK   3    SELECTION: chain 'E' and (resid 17 through 31 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -26.4799 -69.6169  15.4769              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2703 T22:   0.1319                                     
REMARK   3      T33:   0.3368 T12:   0.0127                                     
REMARK   3      T13:  -0.0192 T23:   0.0410                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.5357 L22:   3.7775                                     
REMARK   3      L33:   6.9150 L12:  -1.5353                                     
REMARK   3      L13:  -1.5780 L23:   1.1588                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1067 S12:  -0.3920 S13:  -0.1653                       
REMARK   3      S21:  -0.0970 S22:   0.1055 S23:   0.3864                       
REMARK   3      S31:   0.4379 S32:  -0.2110 S33:   0.0147                       
REMARK   3   TLS GROUP : 23                                                     
REMARK   3    SELECTION: chain 'E' and (resid 40 through 49 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -28.5858 -53.2869  -7.2085              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6067 T22:   0.2683                                     
REMARK   3      T33:   0.3177 T12:   0.0931                                     
REMARK   3      T13:  -0.0288 T23:  -0.0252                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   9.7855 L22:   7.6651                                     
REMARK   3      L33:   2.0956 L12:  -4.7759                                     
REMARK   3      L13:  -2.0699 L23:   0.2885                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2831 S12:  -0.3111 S13:   0.5084                       
REMARK   3      S21:   0.2992 S22:  -0.1263 S23:   0.4941                       
REMARK   3      S31:  -0.7941 S32:  -0.1008 S33:  -0.1777                       
REMARK   3   TLS GROUP : 24                                                     
REMARK   3    SELECTION: chain 'E' and (resid 50 through 60 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -19.3021 -58.0553 -15.0692              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4960 T22:   0.3321                                     
REMARK   3      T33:   0.2232 T12:   0.0906                                     
REMARK   3      T13:  -0.0770 T23:   0.0206                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.5118 L22:   8.1233                                     
REMARK   3      L33:   2.7764 L12:   3.7116                                     
REMARK   3      L13:  -4.4033 L23:  -2.2635                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2986 S12:   0.4045 S13:   0.1198                       
REMARK   3      S21:  -0.4053 S22:  -0.2043 S23:   0.1060                       
REMARK   3      S31:   0.2004 S32:  -0.1161 S33:  -0.1152                       
REMARK   3   TLS GROUP : 25                                                     
REMARK   3    SELECTION: chain 'E' and (resid 61 through 69 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -13.9633 -67.4915  -6.4324              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4146 T22:   0.3951                                     
REMARK   3      T33:   0.2258 T12:   0.0760                                     
REMARK   3      T13:  -0.0718 T23:  -0.0071                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.6074 L22:   3.6125                                     
REMARK   3      L33:   5.0368 L12:  -1.7337                                     
REMARK   3      L13:   0.4245 L23:  -3.7836                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0415 S12:  -0.2093 S13:  -0.3580                       
REMARK   3      S21:  -0.4040 S22:  -0.3118 S23:   0.0780                       
REMARK   3      S31:   0.0140 S32:   0.5854 S33:   0.2415                       
REMARK   3   TLS GROUP : 26                                                     
REMARK   3    SELECTION: chain 'E' and (resid 70 through 80 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -12.9088 -64.0235 -16.0028              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5711 T22:   0.2357                                     
REMARK   3      T33:   0.3443 T12:   0.0861                                     
REMARK   3      T13:  -0.0205 T23:  -0.0733                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.9523 L22:   2.5421                                     
REMARK   3      L33:   9.7963 L12:  -0.9733                                     
REMARK   3      L13:  -4.6714 L23:   1.3064                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2564 S12:   0.3210 S13:  -0.6782                       
REMARK   3      S21:  -0.6503 S22:  -0.1164 S23:  -0.3032                       
REMARK   3      S31:   0.7232 S32:  -0.7722 S33:   0.0482                       
REMARK   3   TLS GROUP : 27                                                     
REMARK   3    SELECTION: chain 'E' and (resid 81 through 90 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  -4.5520 -62.2057 -11.1154              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4508 T22:   0.6326                                     
REMARK   3      T33:   0.7209 T12:  -0.0024                                     
REMARK   3      T13:   0.0262 T23:   0.0648                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.4629 L22:   2.7839                                     
REMARK   3      L33:   2.5118 L12:  -2.1249                                     
REMARK   3      L13:   0.5974 L23:   0.9715                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.6156 S12:   0.2915 S13:  -0.2151                       
REMARK   3      S21:   0.3433 S22:  -0.0793 S23:  -1.7410                       
REMARK   3      S31:  -0.2281 S32:   1.6318 S33:   0.4784                       
REMARK   3   TLS GROUP : 28                                                     
REMARK   3    SELECTION: chain 'E' and (resid 91 through 96 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  -4.1590 -66.7687  -7.1309              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6259 T22:   0.5477                                     
REMARK   3      T33:   0.8236 T12:   0.0672                                     
REMARK   3      T13:  -0.0247 T23:   0.0102                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.3701 L22:   1.7115                                     
REMARK   3      L33:   8.5124 L12:  -1.1767                                     
REMARK   3      L13:   2.2340 L23:  -3.7944                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   1.0357 S12:   0.7831 S13:  -0.9006                       
REMARK   3      S21:   0.2856 S22:  -1.5222 S23:   0.6659                       
REMARK   3      S31:   0.6531 S32:   0.9344 S33:   0.4832                       
REMARK   3   TLS GROUP : 29                                                     
REMARK   3    SELECTION: chain 'E' and (resid 97 through 116 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): -24.9810 -67.0578 -11.3403              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5410 T22:   0.2970                                     
REMARK   3      T33:   0.2856 T12:   0.0075                                     
REMARK   3      T13:  -0.0989 T23:  -0.0623                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.2983 L22:   7.3483                                     
REMARK   3      L33:   2.0402 L12:  -4.4191                                     
REMARK   3      L13:  -2.6478 L23:  -0.2748                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1138 S12:   0.5131 S13:  -0.5962                       
REMARK   3      S21:  -0.4867 S22:  -0.1316 S23:   0.3410                       
REMARK   3      S31:   0.2673 S32:  -0.1871 S33:   0.0260                       
REMARK   3   TLS GROUP : 30                                                     
REMARK   3    SELECTION: chain 'C' and (resid 6 through 16 )                    
REMARK   3    ORIGIN FOR THE GROUP (A):  27.1546  22.9919 -27.3531              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5660 T22:   0.5649                                     
REMARK   3      T33:   0.4951 T12:  -0.1337                                     
REMARK   3      T13:   0.0640 T23:  -0.0961                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   9.1548 L22:   9.4460                                     
REMARK   3      L33:   3.8721 L12:  -5.6502                                     
REMARK   3      L13:   5.8439 L23:  -4.5177                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.5189 S12:  -0.6508 S13:   0.3010                       
REMARK   3      S21:   1.4329 S22:   0.0514 S23:   0.6138                       
REMARK   3      S31:  -1.2689 S32:  -0.0235 S33:   0.4644                       
REMARK   3   TLS GROUP : 31                                                     
REMARK   3    SELECTION: chain 'C' and (resid 17 through 48 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  36.4205  10.5486 -37.5717              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2208 T22:   0.5052                                     
REMARK   3      T33:   0.2697 T12:  -0.1261                                     
REMARK   3      T13:   0.0097 T23:  -0.0679                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.0220 L22:   7.9717                                     
REMARK   3      L33:   1.3463 L12:  -0.6870                                     
REMARK   3      L13:  -0.7228 L23:  -1.1814                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0188 S12:  -0.0041 S13:   0.2091                       
REMARK   3      S21:  -0.2617 S22:   0.2610 S23:  -0.1685                       
REMARK   3      S31:  -0.0162 S32:   0.1310 S33:  -0.2487                       
REMARK   3   TLS GROUP : 32                                                     
REMARK   3    SELECTION: chain 'C' and (resid 49 through 64 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  45.6338   4.0602 -35.6765              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2776 T22:   0.7894                                     
REMARK   3      T33:   0.5283 T12:  -0.0113                                     
REMARK   3      T13:   0.0088 T23:  -0.1006                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.4632 L22:   5.6071                                     
REMARK   3      L33:   6.8340 L12:   2.4726                                     
REMARK   3      L13:   1.3078 L23:  -0.6469                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2462 S12:  -0.3232 S13:  -0.5987                       
REMARK   3      S21:  -0.2419 S22:  -0.1004 S23:  -1.6109                       
REMARK   3      S31:   0.5929 S32:   1.7893 S33:  -0.1579                       
REMARK   3   TLS GROUP : 33                                                     
REMARK   3    SELECTION: chain 'C' and (resid 65 through 72 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  34.9311   0.1136 -37.3663              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3658 T22:   0.5070                                     
REMARK   3      T33:   0.2624 T12:  -0.0616                                     
REMARK   3      T13:  -0.0807 T23:  -0.0088                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.8288 L22:   8.0911                                     
REMARK   3      L33:   9.5409 L12:  -4.1357                                     
REMARK   3      L13:  -6.7724 L23:   5.9100                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3112 S12:  -0.6390 S13:  -0.1141                       
REMARK   3      S21:   0.6007 S22:   0.2270 S23:  -0.2950                       
REMARK   3      S31:   0.9637 S32:  -0.2802 S33:  -0.0053                       
REMARK   3   TLS GROUP : 34                                                     
REMARK   3    SELECTION: chain 'C' and (resid 73 through 85 )                   
REMARK   3    ORIGIN FOR THE GROUP (A):  22.0847  14.3476 -34.2851              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2335 T22:   0.3633                                     
REMARK   3      T33:   0.2953 T12:  -0.0513                                     
REMARK   3      T13:  -0.0589 T23:   0.0380                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.6079 L22:   7.3485                                     
REMARK   3      L33:   7.8203 L12:  -3.7121                                     
REMARK   3      L13:  -3.2273 L23:   1.0218                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0876 S12:   0.5376 S13:   0.1251                       
REMARK   3      S21:  -0.6537 S22:   0.1948 S23:   0.5592                       
REMARK   3      S31:  -0.3146 S32:  -0.3695 S33:  -0.0860                       
REMARK   3   TLS GROUP : 35                                                     
REMARK   3    SELECTION: chain 'C' and (resid 86 through 101 )                  
REMARK   3    ORIGIN FOR THE GROUP (A):  24.1829  17.3686 -51.2387              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4938 T22:   0.4681                                     
REMARK   3      T33:   0.4069 T12:  -0.1878                                     
REMARK   3      T13:  -0.1287 T23:   0.1711                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.4080 L22:   4.3271                                     
REMARK   3      L33:   8.2538 L12:  -1.9559                                     
REMARK   3      L13:  -1.4801 L23:   3.5036                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3869 S12:   0.5820 S13:   0.6562                       
REMARK   3      S21:  -0.8285 S22:   0.0179 S23:   0.3602                       
REMARK   3      S31:  -0.4378 S32:  -0.5738 S33:   0.2517                       
REMARK   3   TLS GROUP : 36                                                     
REMARK   3    SELECTION: chain 'F' and (resid 8 through 35 )                    
REMARK   3    ORIGIN FOR THE GROUP (A): -29.3327 -70.2508   0.8135              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4605 T22:   0.1918                                     
REMARK   3      T33:   0.3659 T12:   0.0268                                     
REMARK   3      T13:  -0.1510 T23:  -0.0360                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.0750 L22:   3.1737                                     
REMARK   3      L33:   5.3349 L12:   0.4173                                     
REMARK   3      L13:  -1.2348 L23:  -0.2749                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0802 S12:   0.4868 S13:   0.0576                       
REMARK   3      S21:  -0.6917 S22:   0.0796 S23:   0.5021                       
REMARK   3      S31:   0.2432 S32:  -0.3638 S33:  -0.0248                       
REMARK   3   TLS GROUP : 37                                                     
REMARK   3    SELECTION: chain 'F' and (resid 36 through 49 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -22.4462 -76.5508   8.1573              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4265 T22:   0.1643                                     
REMARK   3      T33:   0.3487 T12:   0.0184                                     
REMARK   3      T13:  -0.0879 T23:  -0.0248                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.2154 L22:   5.2914                                     
REMARK   3      L33:   7.4204 L12:   0.8364                                     
REMARK   3      L13:  -1.4097 L23:   5.9372                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2363 S12:  -0.4987 S13:  -0.9763                       
REMARK   3      S21:   0.1692 S22:   0.0909 S23:   0.7106                       
REMARK   3      S31:   0.8245 S32:   0.0711 S33:  -0.1779                       
REMARK   3   TLS GROUP : 38                                                     
REMARK   3    SELECTION: chain 'F' and (resid 50 through 64 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -17.2616 -82.9286   2.0390              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5965 T22:   0.3182                                     
REMARK   3      T33:   0.5772 T12:   0.0947                                     
REMARK   3      T13:   0.0070 T23:  -0.1037                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.9854 L22:   4.2320                                     
REMARK   3      L33:   9.8142 L12:   3.5362                                     
REMARK   3      L13:   7.2819 L23:   1.9332                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0791 S12:   0.8307 S13:  -1.0806                       
REMARK   3      S21:  -0.2851 S22:   0.0841 S23:  -0.0483                       
REMARK   3      S31:   0.3800 S32:   0.7323 S33:  -0.1586                       
REMARK   3   TLS GROUP : 39                                                     
REMARK   3    SELECTION: chain 'F' and (resid 65 through 72 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -14.1833 -72.6353   4.0947              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4533 T22:   0.2693                                     
REMARK   3      T33:   0.3636 T12:   0.1143                                     
REMARK   3      T13:  -0.0001 T23:  -0.0543                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.2254 L22:   3.8717                                     
REMARK   3      L33:   6.8440 L12:  -1.1631                                     
REMARK   3      L13:   2.6266 L23:  -4.9649                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3216 S12:   0.7351 S13:  -0.6334                       
REMARK   3      S21:  -1.3632 S22:  -0.4043 S23:  -0.1215                       
REMARK   3      S31:   0.4497 S32:   0.8498 S33:   0.0925                       
REMARK   3   TLS GROUP : 40                                                     
REMARK   3    SELECTION: chain 'F' and (resid 73 through 85 )                   
REMARK   3    ORIGIN FOR THE GROUP (A): -27.8409 -59.2467   1.6036              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4230 T22:   0.1608                                     
REMARK   3      T33:   0.2834 T12:   0.0305                                     
REMARK   3      T13:  -0.1431 T23:  -0.0457                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   7.0510 L22:   7.7459                                     
REMARK   3      L33:   6.5436 L12:  -6.5671                                     
REMARK   3      L13:  -0.7635 L23:  -0.4881                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2895 S12:  -0.0003 S13:   0.4474                       
REMARK   3      S21:  -0.3902 S22:  -0.2281 S23:   0.0340                       
REMARK   3      S31:  -0.7461 S32:  -0.0309 S33:   0.3916                       
REMARK   3   TLS GROUP : 41                                                     
REMARK   3    SELECTION: chain 'F' and (resid 86 through 102 )                  
REMARK   3    ORIGIN FOR THE GROUP (A): -30.2527 -60.8617  18.8742              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.2715 T22:   0.2309                                     
REMARK   3      T33:   0.3071 T12:   0.0847                                     
REMARK   3      T13:   0.0246 T23:  -0.0510                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   8.5543 L22:   6.1090                                     
REMARK   3      L33:   5.5332 L12:  -0.9792                                     
REMARK   3      L13:   1.5862 L23:  -2.7371                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.2516 S12:  -0.8321 S13:   0.0928                       
REMARK   3      S21:   0.1892 S22:   0.3647 S23:   0.5745                       
REMARK   3      S31:  -0.2567 S32:  -0.8950 S33:  -0.1545                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 4S3O COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 08-APR-15.                  
REMARK 100 THE RCSB ID CODE IS RCSB088139.                                      
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 13-JUN-13                          
REMARK 200  TEMPERATURE           (KELVIN) : 110                                
REMARK 200  PH                             : 6.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : ALS                                
REMARK 200  BEAMLINE                       : 5.0.2                              
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.00003                            
REMARK 200  MONOCHROMATOR                  : SI(111)                            
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : ADSC QUANTUM 315R                  
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : SCALEPACK                          
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 52191                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.000                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : -3.000                             
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.8                               
REMARK 200  DATA REDUNDANCY                : 7.200                              
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : 0.06900                            
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 22.5000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : NULL                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : NULL                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: 3RPG, CHAINS A AND C                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 43.01                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.16                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 13.5% PEG 550 MME, 10 MM TCEP, 0.1 M     
REMARK 280  MES PH 6.5, 100 MM KCL, VAPOR DIFFUSION, TEMPERATURE 277K           
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 21 21 21                       
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X+1/2,-Y,Z+1/2                                         
REMARK 290       3555   -X,Y+1/2,-Z+1/2                                         
REMARK 290       4555   X+1/2,-Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000       27.19600            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000       66.20850            
REMARK 290   SMTRY1   3 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       52.64250            
REMARK 290   SMTRY3   3  0.000000  0.000000 -1.000000       66.20850            
REMARK 290   SMTRY1   4  1.000000  0.000000  0.000000       27.19600            
REMARK 290   SMTRY2   4  0.000000 -1.000000  0.000000       52.64250            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 300 REMARK: TWO BIOLOGICAL HETEROTRIMERS APPEAR IN THE ASYMMETRIC UNIT   
REMARK 300 (A,B,C AND D,E,F)                                                    
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: D, E, F                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     GLY B    -1                                                      
REMARK 465     SER B     0                                                      
REMARK 465     MET B     1                                                      
REMARK 465     SER B     2                                                      
REMARK 465     GLN B     3                                                      
REMARK 465     ALA B     4                                                      
REMARK 465     VAL B     5                                                      
REMARK 465     GLN B     6                                                      
REMARK 465     THR B     7                                                      
REMARK 465     ASN B     8                                                      
REMARK 465     GLY B     9                                                      
REMARK 465     GLY B    35                                                      
REMARK 465     GLY B    83                                                      
REMARK 465     GLY E    -1                                                      
REMARK 465     SER E     0                                                      
REMARK 465     MET E     1                                                      
REMARK 465     SER E     2                                                      
REMARK 465     GLN E     3                                                      
REMARK 465     ALA E     4                                                      
REMARK 465     VAL E     5                                                      
REMARK 465     GLN E     6                                                      
REMARK 465     THR E     7                                                      
REMARK 465     ASN E     8                                                      
REMARK 465     GLY E     9                                                      
REMARK 465     ILE E    32                                                      
REMARK 465     THR E    33                                                      
REMARK 465     ASP E    34                                                      
REMARK 465     GLY E    35                                                      
REMARK 465     LEU E    36                                                      
REMARK 465     GLU E    37                                                      
REMARK 465     ILE E    38                                                      
REMARK 465     VAL E    39                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ALA C     2                                                      
REMARK 465     THR C     3                                                      
REMARK 465     GLN C     4                                                      
REMARK 465     ARG C     5                                                      
REMARK 465     HIS C    61                                                      
REMARK 465     LYS C   102                                                      
REMARK 465     PRO C   103                                                      
REMARK 465     GLN C   104                                                      
REMARK 465     GLU C   105                                                      
REMARK 465     ASN C   106                                                      
REMARK 465     GLY C   107                                                      
REMARK 465     GLN C   108                                                      
REMARK 465     ASP C   109                                                      
REMARK 465     LEU C   110                                                      
REMARK 465     GLU C   111                                                      
REMARK 465     HIS C   112                                                      
REMARK 465     HIS C   113                                                      
REMARK 465     HIS C   114                                                      
REMARK 465     HIS C   115                                                      
REMARK 465     HIS C   116                                                      
REMARK 465     HIS C   117                                                      
REMARK 465     MET F     1                                                      
REMARK 465     ALA F     2                                                      
REMARK 465     THR F     3                                                      
REMARK 465     GLN F     4                                                      
REMARK 465     ARG F     5                                                      
REMARK 465     LYS F     6                                                      
REMARK 465     HIS F     7                                                      
REMARK 465     PRO F   103                                                      
REMARK 465     GLN F   104                                                      
REMARK 465     GLU F   105                                                      
REMARK 465     ASN F   106                                                      
REMARK 465     GLY F   107                                                      
REMARK 465     GLN F   108                                                      
REMARK 465     ASP F   109                                                      
REMARK 465     LEU F   110                                                      
REMARK 465     GLU F   111                                                      
REMARK 465     HIS F   112                                                      
REMARK 465     HIS F   113                                                      
REMARK 465     HIS F   114                                                      
REMARK 465     HIS F   115                                                      
REMARK 465     HIS F   116                                                      
REMARK 465     HIS F   117                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LYS A   4    CG   CD   CE   NZ                                   
REMARK 470     GLN A  20    CG   CD   OE1  NE2                                  
REMARK 470     ASP A  42    CG   OD1  OD2                                       
REMARK 470     ARG A  90    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 125    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN A 143    CG   CD   OE1  NE2                                  
REMARK 470     LYS A 144    CG   CD   CE   NZ                                   
REMARK 470     ASP D  28    CG   OD1  OD2                                       
REMARK 470     ASP D  42    CG   OD1  OD2                                       
REMARK 470     LYS D  63    CG   CD   CE   NZ                                   
REMARK 470     LYS D  66    CG   CD   CE   NZ                                   
REMARK 470     GLU D 122    CG   CD   OE1  OE2                                  
REMARK 470     LYS D 128    CG   CD   CE   NZ                                   
REMARK 470     GLU B  37    CG   CD   OE1  OE2                                  
REMARK 470     LYS B  85    CG   CD   CE   NZ                                   
REMARK 470     LYS B  93    CG   CD   CE   NZ                                   
REMARK 470     LYS B  97    CG   CD   CE   NZ                                   
REMARK 470     ARG B  98    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR E  10    OG1  CG2                                            
REMARK 470     ARG E  81    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS E  85    CG   CD   CE   NZ                                   
REMARK 470     LYS E  93    CG   CD   CE   NZ                                   
REMARK 470     LYS E  97    CG   CD   CE   NZ                                   
REMARK 470     ARG E  98    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C   6    CG   CD   CE   NZ                                   
REMARK 470     GLU C  33    CG   CD   OE1  OE2                                  
REMARK 470     GLU C  62    CG   CD   OE1  OE2                                  
REMARK 470     GLU C  77    CG   CD   OE1  OE2                                  
REMARK 470     GLU C  88    CG   CD   OE1  OE2                                  
REMARK 470     GLU C  92    CG   CD   OE1  OE2                                  
REMARK 470     GLU C  96    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 100    CG   CD   CE   NZ                                   
REMARK 470     LEU F   8    CG   CD1  CD2                                       
REMARK 470     LYS F  10    CG   CD   CE   NZ                                   
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OD2  ASP D    29     ND1  HIS D    32              2.18            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ARG A  90     -117.54   -125.55                                   
REMARK 500    ASP A 130       65.97   -151.56                                   
REMARK 500    ARG D  90     -102.32   -134.28                                   
REMARK 500    ASP D 116       40.15    -95.04                                   
REMARK 500    ASP D 117       70.06   -176.37                                   
REMARK 500    ALA D 146       43.22   -100.33                                   
REMARK 500    ARG E  81       77.58   -118.37                                   
REMARK 500    ASN E  84       -3.39     66.03                                   
REMARK 500    ARG E  91       -2.79     76.25                                   
REMARK 500    LYS C  22       -2.53     71.97                                   
REMARK 500    ASP F  49       36.13   -148.25                                   
REMARK 500    VAL F  83       79.12   -117.57                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN E 202  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS E  69   ND1                                                    
REMARK 620 2 CYS E  67   SG  105.2                                              
REMARK 620 3 CYS E  87   SG  113.3 110.9                                        
REMARK 620 4 CYS E  90   SG  108.6 100.9 116.7                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN B 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS B  69   ND1                                                    
REMARK 620 2 CYS B  67   SG  107.3                                              
REMARK 620 3 CYS B  87   SG  110.5 115.3                                        
REMARK 620 4 CYS B  90   SG  109.7  97.5 115.6                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN F 202  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS F  36   ND1                                                    
REMARK 620 2 CYS F  34   SG  107.7                                              
REMARK 620 3 CYS F  53   SG  112.5 111.7                                        
REMARK 620 4 CYS F  56   SG  108.0 108.3 108.6                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN C 202  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS C  36   ND1                                                    
REMARK 620 2 CYS C  34   SG  102.4                                              
REMARK 620 3 CYS C  53   SG  118.1 109.4                                        
REMARK 620 4 CYS C  56   SG  107.8 107.9 110.5                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN C 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS C  21   SG                                                     
REMARK 620 2 CYS C  42   SG  109.9                                              
REMARK 620 3 CYS C  18   SG  109.4 113.8                                        
REMARK 620 4 CYS C  39   SG  102.4 112.9 107.7                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN F 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS F  18   SG                                                     
REMARK 620 2 CYS F  21   SG  109.7                                              
REMARK 620 3 CYS F  42   SG  113.3 109.7                                        
REMARK 620 4 CYS F  39   SG  106.4 104.2 113.1                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN E 201  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS E  72   SG                                                     
REMARK 620 2 CYS E  54   SG  103.8                                              
REMARK 620 3 CYS E  75   SG  113.2 110.9                                        
REMARK 620 4 CYS E  51   SG  104.3 109.0 114.9                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN B 200  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B  54   SG                                                     
REMARK 620 2 CYS B  75   SG  110.8                                              
REMARK 620 3 CYS B  72   SG  106.1 112.4                                        
REMARK 620 4 CYS B  51   SG  108.6 114.2 104.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN B 200                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN B 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN E 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN E 202                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN C 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN C 202                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN F 201                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN F 202                  
DBREF  4S3O A    2   147  UNP    P61077   UB2D3_HUMAN      2    147             
DBREF  4S3O D    2   147  UNP    P61077   UB2D3_HUMAN      2    147             
DBREF  4S3O B    1   116  UNP    Q99496   RING2_HUMAN      1    116             
DBREF  4S3O E    1   116  UNP    Q99496   RING2_HUMAN      1    116             
DBREF  4S3O C    1   109  UNP    Q86SE9   PCGF5_HUMAN      1    109             
DBREF  4S3O F    1   109  UNP    Q86SE9   PCGF5_HUMAN      1    109             
SEQADV 4S3O GLY A    0  UNP  P61077              EXPRESSION TAG                 
SEQADV 4S3O SER A    1  UNP  P61077              EXPRESSION TAG                 
SEQADV 4S3O GLY D    0  UNP  P61077              EXPRESSION TAG                 
SEQADV 4S3O SER D    1  UNP  P61077              EXPRESSION TAG                 
SEQADV 4S3O GLY B   -1  UNP  Q99496              EXPRESSION TAG                 
SEQADV 4S3O SER B    0  UNP  Q99496              EXPRESSION TAG                 
SEQADV 4S3O GLY E   -1  UNP  Q99496              EXPRESSION TAG                 
SEQADV 4S3O SER E    0  UNP  Q99496              EXPRESSION TAG                 
SEQADV 4S3O LEU C  110  UNP  Q86SE9              EXPRESSION TAG                 
SEQADV 4S3O GLU C  111  UNP  Q86SE9              EXPRESSION TAG                 
SEQADV 4S3O HIS C  112  UNP  Q86SE9              EXPRESSION TAG                 
SEQADV 4S3O HIS C  113  UNP  Q86SE9              EXPRESSION TAG                 
SEQADV 4S3O HIS C  114  UNP  Q86SE9              EXPRESSION TAG                 
SEQADV 4S3O HIS C  115  UNP  Q86SE9              EXPRESSION TAG                 
SEQADV 4S3O HIS C  116  UNP  Q86SE9              EXPRESSION TAG                 
SEQADV 4S3O HIS C  117  UNP  Q86SE9              EXPRESSION TAG                 
SEQADV 4S3O LEU F  110  UNP  Q86SE9              EXPRESSION TAG                 
SEQADV 4S3O GLU F  111  UNP  Q86SE9              EXPRESSION TAG                 
SEQADV 4S3O HIS F  112  UNP  Q86SE9              EXPRESSION TAG                 
SEQADV 4S3O HIS F  113  UNP  Q86SE9              EXPRESSION TAG                 
SEQADV 4S3O HIS F  114  UNP  Q86SE9              EXPRESSION TAG                 
SEQADV 4S3O HIS F  115  UNP  Q86SE9              EXPRESSION TAG                 
SEQADV 4S3O HIS F  116  UNP  Q86SE9              EXPRESSION TAG                 
SEQADV 4S3O HIS F  117  UNP  Q86SE9              EXPRESSION TAG                 
SEQRES   1 A  148  GLY SER ALA LEU LYS ARG ILE ASN LYS GLU LEU SER ASP          
SEQRES   2 A  148  LEU ALA ARG ASP PRO PRO ALA GLN CYS SER ALA GLY PRO          
SEQRES   3 A  148  VAL GLY ASP ASP MET PHE HIS TRP GLN ALA THR ILE MET          
SEQRES   4 A  148  GLY PRO ASN ASP SER PRO TYR GLN GLY GLY VAL PHE PHE          
SEQRES   5 A  148  LEU THR ILE HIS PHE PRO THR ASP TYR PRO PHE LYS PRO          
SEQRES   6 A  148  PRO LYS VAL ALA PHE THR THR ARG ILE TYR HIS PRO ASN          
SEQRES   7 A  148  ILE ASN SER ASN GLY SER ILE CYS LEU ASP ILE LEU ARG          
SEQRES   8 A  148  SER GLN TRP SER PRO ALA LEU THR ILE SER LYS VAL LEU          
SEQRES   9 A  148  LEU SER ILE CYS SER LEU LEU CYS ASP PRO ASN PRO ASP          
SEQRES  10 A  148  ASP PRO LEU VAL PRO GLU ILE ALA ARG ILE TYR LYS THR          
SEQRES  11 A  148  ASP ARG ASP LYS TYR ASN ARG ILE SER ARG GLU TRP THR          
SEQRES  12 A  148  GLN LYS TYR ALA MET                                          
SEQRES   1 D  148  GLY SER ALA LEU LYS ARG ILE ASN LYS GLU LEU SER ASP          
SEQRES   2 D  148  LEU ALA ARG ASP PRO PRO ALA GLN CYS SER ALA GLY PRO          
SEQRES   3 D  148  VAL GLY ASP ASP MET PHE HIS TRP GLN ALA THR ILE MET          
SEQRES   4 D  148  GLY PRO ASN ASP SER PRO TYR GLN GLY GLY VAL PHE PHE          
SEQRES   5 D  148  LEU THR ILE HIS PHE PRO THR ASP TYR PRO PHE LYS PRO          
SEQRES   6 D  148  PRO LYS VAL ALA PHE THR THR ARG ILE TYR HIS PRO ASN          
SEQRES   7 D  148  ILE ASN SER ASN GLY SER ILE CYS LEU ASP ILE LEU ARG          
SEQRES   8 D  148  SER GLN TRP SER PRO ALA LEU THR ILE SER LYS VAL LEU          
SEQRES   9 D  148  LEU SER ILE CYS SER LEU LEU CYS ASP PRO ASN PRO ASP          
SEQRES  10 D  148  ASP PRO LEU VAL PRO GLU ILE ALA ARG ILE TYR LYS THR          
SEQRES  11 D  148  ASP ARG ASP LYS TYR ASN ARG ILE SER ARG GLU TRP THR          
SEQRES  12 D  148  GLN LYS TYR ALA MET                                          
SEQRES   1 B  118  GLY SER MET SER GLN ALA VAL GLN THR ASN GLY THR GLN          
SEQRES   2 B  118  PRO LEU SER LYS THR TRP GLU LEU SER LEU TYR GLU LEU          
SEQRES   3 B  118  GLN ARG THR PRO GLN GLU ALA ILE THR ASP GLY LEU GLU          
SEQRES   4 B  118  ILE VAL VAL SER PRO ARG SER LEU HIS SER GLU LEU MET          
SEQRES   5 B  118  CYS PRO ILE CYS LEU ASP MET LEU LYS ASN THR MET THR          
SEQRES   6 B  118  THR LYS GLU CYS LEU HIS ARG PHE CYS ALA ASP CYS ILE          
SEQRES   7 B  118  ILE THR ALA LEU ARG SER GLY ASN LYS GLU CYS PRO THR          
SEQRES   8 B  118  CYS ARG LYS LYS LEU VAL SER LYS ARG SER LEU ARG PRO          
SEQRES   9 B  118  ASP PRO ASN PHE ASP ALA LEU ILE SER LYS ILE TYR PRO          
SEQRES  10 B  118  SER                                                          
SEQRES   1 E  118  GLY SER MET SER GLN ALA VAL GLN THR ASN GLY THR GLN          
SEQRES   2 E  118  PRO LEU SER LYS THR TRP GLU LEU SER LEU TYR GLU LEU          
SEQRES   3 E  118  GLN ARG THR PRO GLN GLU ALA ILE THR ASP GLY LEU GLU          
SEQRES   4 E  118  ILE VAL VAL SER PRO ARG SER LEU HIS SER GLU LEU MET          
SEQRES   5 E  118  CYS PRO ILE CYS LEU ASP MET LEU LYS ASN THR MET THR          
SEQRES   6 E  118  THR LYS GLU CYS LEU HIS ARG PHE CYS ALA ASP CYS ILE          
SEQRES   7 E  118  ILE THR ALA LEU ARG SER GLY ASN LYS GLU CYS PRO THR          
SEQRES   8 E  118  CYS ARG LYS LYS LEU VAL SER LYS ARG SER LEU ARG PRO          
SEQRES   9 E  118  ASP PRO ASN PHE ASP ALA LEU ILE SER LYS ILE TYR PRO          
SEQRES  10 E  118  SER                                                          
SEQRES   1 C  117  MET ALA THR GLN ARG LYS HIS LEU VAL LYS ASP PHE ASN          
SEQRES   2 C  117  PRO TYR ILE THR CYS TYR ILE CYS LYS GLY TYR LEU ILE          
SEQRES   3 C  117  LYS PRO THR THR VAL THR GLU CYS LEU HIS THR PHE CYS          
SEQRES   4 C  117  LYS THR CYS ILE VAL GLN HIS PHE GLU ASP SER ASN ASP          
SEQRES   5 C  117  CYS PRO ARG CYS GLY ASN GLN VAL HIS GLU THR ASN PRO          
SEQRES   6 C  117  LEU GLU MET LEU ARG LEU ASP ASN THR LEU GLU GLU ILE          
SEQRES   7 C  117  ILE PHE LYS LEU VAL PRO GLY LEU ARG GLU GLN GLU LEU          
SEQRES   8 C  117  GLU ARG GLU SER GLU PHE TRP LYS LYS ASN LYS PRO GLN          
SEQRES   9 C  117  GLU ASN GLY GLN ASP LEU GLU HIS HIS HIS HIS HIS HIS          
SEQRES   1 F  117  MET ALA THR GLN ARG LYS HIS LEU VAL LYS ASP PHE ASN          
SEQRES   2 F  117  PRO TYR ILE THR CYS TYR ILE CYS LYS GLY TYR LEU ILE          
SEQRES   3 F  117  LYS PRO THR THR VAL THR GLU CYS LEU HIS THR PHE CYS          
SEQRES   4 F  117  LYS THR CYS ILE VAL GLN HIS PHE GLU ASP SER ASN ASP          
SEQRES   5 F  117  CYS PRO ARG CYS GLY ASN GLN VAL HIS GLU THR ASN PRO          
SEQRES   6 F  117  LEU GLU MET LEU ARG LEU ASP ASN THR LEU GLU GLU ILE          
SEQRES   7 F  117  ILE PHE LYS LEU VAL PRO GLY LEU ARG GLU GLN GLU LEU          
SEQRES   8 F  117  GLU ARG GLU SER GLU PHE TRP LYS LYS ASN LYS PRO GLN          
SEQRES   9 F  117  GLU ASN GLY GLN ASP LEU GLU HIS HIS HIS HIS HIS HIS          
HET     ZN  B 200       1                                                       
HET     ZN  B 201       1                                                       
HET     ZN  E 201       1                                                       
HET     ZN  E 202       1                                                       
HET     ZN  C 201       1                                                       
HET     ZN  C 202       1                                                       
HET     ZN  F 201       1                                                       
HET     ZN  F 202       1                                                       
HETNAM      ZN ZINC ION                                                         
FORMUL   7   ZN    8(ZN 2+)                                                     
FORMUL  15  HOH   *152(H2 O)                                                    
HELIX    1   1 GLY A    0  ASP A   16  1                                  17    
HELIX    2   2 LEU A   86  ARG A   90  5                                   5    
HELIX    3   3 THR A   98  ASP A  112  1                                  15    
HELIX    4   4 VAL A  120  ASP A  130  1                                  11    
HELIX    5   5 ASP A  130  ALA A  146  1                                  17    
HELIX    6   6 SER D    1  ASP D   16  1                                  16    
HELIX    7   7 LEU D   86  ARG D   90  5                                   5    
HELIX    8   8 THR D   98  ASP D  112  1                                  15    
HELIX    9   9 VAL D  120  ASP D  130  1                                  11    
HELIX   10  10 ASP D  130  ALA D  146  1                                  17    
HELIX   11  11 PRO B   12  TRP B   17  1                                   6    
HELIX   12  12 SER B   20  GLN B   25  1                                   6    
HELIX   13  13 SER B   41  SER B   44  5                                   4    
HELIX   14  14 LEU B   45  MET B   50  1                                   6    
HELIX   15  15 ALA B   73  ARG B   81  1                                   9    
HELIX   16  16 SER B   96  ARG B   98  5                                   3    
HELIX   17  17 ASP B  103  TYR B  114  1                                  12    
HELIX   18  18 PRO E   12  TRP E   17  1                                   6    
HELIX   19  19 TYR E   22  ARG E   26  5                                   5    
HELIX   20  20 SER E   41  SER E   44  5                                   4    
HELIX   21  21 LEU E   45  MET E   50  1                                   6    
HELIX   22  22 ALA E   73  ARG E   81  1                                   9    
HELIX   23  23 SER E   96  ARG E   98  5                                   3    
HELIX   24  24 ASP E  103  TYR E  114  1                                  12    
HELIX   25  25 LEU C    8  ASP C   11  5                                   4    
HELIX   26  26 PHE C   12  THR C   17  1                                   6    
HELIX   27  27 LYS C   40  PHE C   47  1                                   8    
HELIX   28  28 ASN C   64  GLU C   67  5                                   4    
HELIX   29  29 ASP C   72  VAL C   83  1                                  12    
HELIX   30  30 GLY C   85  LYS C   99  1                                  15    
HELIX   31  31 LYS C  100  ASN C  101  5                                   2    
HELIX   32  32 LEU F    8  ASP F   11  5                                   4    
HELIX   33  33 PHE F   12  THR F   17  1                                   6    
HELIX   34  34 LYS F   40  GLU F   48  1                                   9    
HELIX   35  35 ASN F   64  GLU F   67  5                                   4    
HELIX   36  36 ASP F   72  VAL F   83  1                                  12    
HELIX   37  37 GLY F   85  ASN F  101  1                                  17    
SHEET    1   A 4 CYS A  21  PRO A  25  0                                        
SHEET    2   A 4 HIS A  32  MET A  38 -1  O  THR A  36   N  SER A  22           
SHEET    3   A 4 VAL A  49  HIS A  55 -1  O  PHE A  50   N  ILE A  37           
SHEET    4   A 4 LYS A  66  PHE A  69 -1  O  LYS A  66   N  HIS A  55           
SHEET    1   B 4 CYS D  21  VAL D  26  0                                        
SHEET    2   B 4 ASP D  29  MET D  38 -1  O  GLN D  34   N  GLY D  24           
SHEET    3   B 4 VAL D  49  HIS D  55 -1  O  PHE D  50   N  ILE D  37           
SHEET    4   B 4 LYS D  66  PHE D  69 -1  O  LYS D  66   N  HIS D  55           
SHEET    1   C 3 ARG B  70  CYS B  72  0                                        
SHEET    2   C 3 THR B  61  THR B  64 -1  N  MET B  62   O  PHE B  71           
SHEET    3   C 3 LEU B 100  PRO B 102 -1  O  ARG B 101   N  THR B  63           
SHEET    1   D 3 ARG E  70  CYS E  72  0                                        
SHEET    2   D 3 THR E  61  THR E  64 -1  N  MET E  62   O  PHE E  71           
SHEET    3   D 3 LEU E 100  PRO E 102 -1  O  ARG E 101   N  THR E  63           
SHEET    1   E 3 HIS C  36  CYS C  39  0                                        
SHEET    2   E 3 PRO C  28  VAL C  31 -1  N  VAL C  31   O  HIS C  36           
SHEET    3   E 3 LEU C  69  LEU C  71 -1  O  ARG C  70   N  THR C  30           
SHEET    1   F 3 HIS F  36  CYS F  39  0                                        
SHEET    2   F 3 PRO F  28  VAL F  31 -1  N  THR F  29   O  PHE F  38           
SHEET    3   F 3 LEU F  69  LEU F  71 -1  O  ARG F  70   N  THR F  30           
LINK         ND1 HIS E  69                ZN    ZN E 202     1555   1555  1.96  
LINK         ND1 HIS B  69                ZN    ZN B 201     1555   1555  2.02  
LINK         ND1 HIS F  36                ZN    ZN F 202     1555   1555  2.05  
LINK         ND1 HIS C  36                ZN    ZN C 202     1555   1555  2.07  
LINK         SG  CYS F  34                ZN    ZN F 202     1555   1555  2.19  
LINK         SG  CYS C  21                ZN    ZN C 201     1555   1555  2.22  
LINK         SG  CYS E  67                ZN    ZN E 202     1555   1555  2.27  
LINK         SG  CYS F  18                ZN    ZN F 201     1555   1555  2.28  
LINK         SG  CYS E  72                ZN    ZN E 201     1555   1555  2.28  
LINK         SG  CYS C  42                ZN    ZN C 201     1555   1555  2.29  
LINK         SG  CYS C  34                ZN    ZN C 202     1555   1555  2.30  
LINK         SG  CYS E  87                ZN    ZN E 202     1555   1555  2.30  
LINK         SG  CYS B  67                ZN    ZN B 201     1555   1555  2.31  
LINK         SG  CYS F  21                ZN    ZN F 201     1555   1555  2.31  
LINK         SG  CYS C  53                ZN    ZN C 202     1555   1555  2.31  
LINK         SG  CYS E  54                ZN    ZN E 201     1555   1555  2.31  
LINK         SG  CYS E  75                ZN    ZN E 201     1555   1555  2.32  
LINK         SG  CYS B  54                ZN    ZN B 200     1555   1555  2.34  
LINK         SG  CYS B  75                ZN    ZN B 200     1555   1555  2.35  
LINK         SG  CYS B  87                ZN    ZN B 201     1555   1555  2.38  
LINK         SG  CYS C  18                ZN    ZN C 201     1555   1555  2.38  
LINK         SG  CYS F  42                ZN    ZN F 201     1555   1555  2.38  
LINK         SG  CYS B  90                ZN    ZN B 201     1555   1555  2.38  
LINK         SG  CYS E  51                ZN    ZN E 201     1555   1555  2.38  
LINK         SG  CYS F  53                ZN    ZN F 202     1555   1555  2.39  
LINK         SG  CYS F  56                ZN    ZN F 202     1555   1555  2.40  
LINK         SG  CYS C  56                ZN    ZN C 202     1555   1555  2.42  
LINK         SG  CYS B  72                ZN    ZN B 200     1555   1555  2.42  
LINK         SG  CYS B  51                ZN    ZN B 200     1555   1555  2.44  
LINK         SG  CYS E  90                ZN    ZN E 202     1555   1555  2.45  
LINK         SG  CYS F  39                ZN    ZN F 201     1555   1555  2.45  
LINK         SG  CYS C  39                ZN    ZN C 201     1555   1555  2.46  
CISPEP   1 TYR A   60    PRO A   61          0         9.19                     
CISPEP   2 TYR D   60    PRO D   61          0         6.75                     
CISPEP   3 ARG E   81    SER E   82          0         1.38                     
CISPEP   4 SER E   82    GLY E   83          0        -2.94                     
SITE     1 AC1  4 CYS B  51  CYS B  54  CYS B  72  CYS B  75                    
SITE     1 AC2  4 CYS B  67  HIS B  69  CYS B  87  CYS B  90                    
SITE     1 AC3  4 CYS E  51  CYS E  54  CYS E  72  CYS E  75                    
SITE     1 AC4  4 CYS E  67  HIS E  69  CYS E  87  CYS E  90                    
SITE     1 AC5  4 CYS C  18  CYS C  21  CYS C  39  CYS C  42                    
SITE     1 AC6  4 CYS C  34  HIS C  36  CYS C  53  CYS C  56                    
SITE     1 AC7  4 CYS F  18  CYS F  21  CYS F  39  CYS F  42                    
SITE     1 AC8  4 CYS F  34  HIS F  36  CYS F  53  CYS F  56                    
CRYST1   54.392  105.285  132.417  90.00  90.00  90.00 P 21 21 21    8          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.018385  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.009498  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.007552        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system