GenomeNet

Database: PDB
Entry: 4UI9
LinkDB: 4UI9
Original site: 4UI9 
HEADER    CELL CYCLE                              27-MAR-15   4UI9              
TITLE     ATOMIC STRUCTURE OF THE HUMAN ANAPHASE-PROMOTING COMPLEX              
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 1;                      
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: APC1, CYCLOSOME SUBUNIT 1, MITOTIC CHECKPOINT REGULATOR,    
COMPND   5 TESTIS-SPECIFIC GENE 24 PROTEIN, APC1, CYCLOSOME SUBUNIT 1, MITOTIC  
COMPND   6 CHECKPOINT REGULATOR, TESTIS-SPECIFIC GENE 24 PROTEIN;               
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 11;                     
COMPND   9 CHAIN: B;                                                            
COMPND  10 SYNONYM: APC11, CYCLOSOME SUBUNIT 11, HEPATOCELLULAR CARCINOMA-      
COMPND  11 ASSOCIATED RING FINGER PROTEIN, APC11, CYCLOSOME SUBUNIT 11,         
COMPND  12 HEPATOCELLULAR CARCINOMA- ASSOCIATED RING FINGER PROTEIN;            
COMPND  13 MOL_ID: 3;                                                           
COMPND  14 MOLECULE: CELL DIVISION CYCLE PROTEIN 23 HOMOLOG;                    
COMPND  15 CHAIN: C, P;                                                         
COMPND  16 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, APC8, CYCLOSOME       
COMPND  17 SUBUNIT 8, ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, APC8, CYCLOSOME     
COMPND  18 SUBUNIT 8;                                                           
COMPND  19 MOL_ID: 4;                                                           
COMPND  20 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 15;                     
COMPND  21 CHAIN: D;                                                            
COMPND  22 SYNONYM: APC15, APC15;                                               
COMPND  23 MOL_ID: 5;                                                           
COMPND  24 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 16;                     
COMPND  25 CHAIN: E;                                                            
COMPND  26 SYNONYM: APC16, CYCLOSOME SUBUNIT 16, APC16, CYCLOSOME SUBUNIT 16;   
COMPND  27 MOL_ID: 6;                                                           
COMPND  28 MOLECULE: CELL DIVISION CYCLE PROTEIN 27 HOMOLOG;                    
COMPND  29 CHAIN: F, H;                                                         
COMPND  30 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 3, APC3, CDC27 HOMOLOG,  
COMPND  31 CDC27HS, H-NUC, ANAPHASE-PROMOTING COMPLEX SUBUNIT 3, APC3, CDC27    
COMPND  32 HOMOLOG, CDC27HS, H-NUC;                                             
COMPND  33 MOL_ID: 7;                                                           
COMPND  34 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26;                  
COMPND  35 CHAIN: G;                                                            
COMPND  36 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 12, APC12, CELL DIVISION 
COMPND  37 CYCLE PROTEIN 26 HOMOLOG, ANAPHASE-PROMOTING COMPLEX SUBUNIT 12,     
COMPND  38 APC12, CELL DIVISION CYCLE PROTEIN 26 HOMOLOG;                       
COMPND  39 MOL_ID: 8;                                                           
COMPND  40 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 4;                      
COMPND  41 CHAIN: I;                                                            
COMPND  42 SYNONYM: APC4, CYCLOSOME SUBUNIT 4, APC4, CYCLOSOME SUBUNIT 4;       
COMPND  43 MOL_ID: 9;                                                           
COMPND  44 MOLECULE: CELL DIVISION CYCLE PROTEIN 16 HOMOLOG;                    
COMPND  45 CHAIN: J;                                                            
COMPND  46 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 6, APC6, CDC16 HOMOLOG,  
COMPND  47 CDC16HS, CYCLOSOME SUBUNIT 6, ANAPHASE-PROMOTING COMPLEX SUBUNIT 6,  
COMPND  48 APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6;                   
COMPND  49 MOL_ID: 10;                                                          
COMPND  50 MOLECULE: CELL DIVISION CYCLE PROTEIN 16 HOMOLOG;                    
COMPND  51 CHAIN: K;                                                            
COMPND  52 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 6, APC6, CDC16 HOMOLOG,  
COMPND  53 CDC16HS, CYCLOSOME SUBUNIT 6, ANAPHASE-PROMOTING COMPLEX SUBUNIT 6,  
COMPND  54 APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6;                   
COMPND  55 MOL_ID: 11;                                                          
COMPND  56 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 10;                     
COMPND  57 CHAIN: L;                                                            
COMPND  58 SYNONYM: APC10, CYCLOSOME SUBUNIT 10, APC10, CYCLOSOME SUBUNIT 10;   
COMPND  59 MOL_ID: 12;                                                          
COMPND  60 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 13;                     
COMPND  61 CHAIN: M;                                                            
COMPND  62 SYNONYM: APC13, CYCLOSOME SUBUNIT 13, APC13, CYCLOSOME SUBUNIT 13;   
COMPND  63 MOL_ID: 13;                                                          
COMPND  64 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 2;                      
COMPND  65 CHAIN: N;                                                            
COMPND  66 SYNONYM: APC2, CYCLOSOME SUBUNIT 2, APC2, CYCLOSOME SUBUNIT 2;       
COMPND  67 MOL_ID: 14;                                                          
COMPND  68 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 5;                      
COMPND  69 CHAIN: O;                                                            
COMPND  70 SYNONYM: APC5, CYCLOSOME SUBUNIT 5, APC5, CYCLOSOME SUBUNIT 5;       
COMPND  71 MOL_ID: 15;                                                          
COMPND  72 MOLECULE: FIZZY-RELATED PROTEIN HOMOLOG;                             
COMPND  73 CHAIN: R;                                                            
COMPND  74 SYNONYM: FZR, CDC20-LIKE PROTEIN 1, CDH1/HCT1 HOMOLOG, HCDH1, FZR, C 
COMPND  75 DC20-LIKE PROTEIN 1, CDH1/HCT1 HOMOLOG, HCDH1;                       
COMPND  76 MOL_ID: 16;                                                          
COMPND  77 MOLECULE: F-BOX ONLY PROTEIN 5;                                      
COMPND  78 CHAIN: S;                                                            
COMPND  79 SYNONYM: EARLY MITOTIC INHIBITOR 1, EARLY MITOTIC INHIBITOR 1;       
COMPND  80 MOL_ID: 17;                                                          
COMPND  81 MOLECULE: PEPTIDE;                                                   
COMPND  82 CHAIN: T;                                                            
COMPND  83 MOL_ID: 18;                                                          
COMPND  84 MOLECULE: PEPTIDE;                                                   
COMPND  85 CHAIN: U;                                                            
COMPND  86 MOL_ID: 19;                                                          
COMPND  87 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26;                  
COMPND  88 CHAIN: W;                                                            
COMPND  89 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 12, APC12, CELL DIVISION 
COMPND  90 CYCLE PROTEIN 26 HOMOLOG, ANAPHASE-PROMOTING COMPLEX SUBUNIT 12,     
COMPND  91 APC12, CELL DIVISION CYCLE PROTEIN 26 HOMOLOG;                       
COMPND  92 MOL_ID: 20;                                                          
COMPND  93 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 7;                      
COMPND  94 CHAIN: X, Y;                                                         
COMPND  95 SYNONYM: APC7, CYCLOSOME SUBUNIT 7, APC7, CYCLOSOME SUBUNIT 7        
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 MOL_ID: 2;                                                           
SOURCE   6 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   7 ORGANISM_COMMON: HUMAN;                                              
SOURCE   8 ORGANISM_TAXID: 9606;                                                
SOURCE   9 MOL_ID: 3;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  11 ORGANISM_COMMON: HUMAN;                                              
SOURCE  12 ORGANISM_TAXID: 9606;                                                
SOURCE  13 MOL_ID: 4;                                                           
SOURCE  14 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  15 ORGANISM_COMMON: HUMAN;                                              
SOURCE  16 ORGANISM_TAXID: 9606;                                                
SOURCE  17 MOL_ID: 5;                                                           
SOURCE  18 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  19 ORGANISM_COMMON: HUMAN;                                              
SOURCE  20 ORGANISM_TAXID: 9606;                                                
SOURCE  21 MOL_ID: 6;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  23 ORGANISM_COMMON: HUMAN;                                              
SOURCE  24 ORGANISM_TAXID: 9606;                                                
SOURCE  25 MOL_ID: 7;                                                           
SOURCE  26 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  27 ORGANISM_COMMON: HUMAN;                                              
SOURCE  28 ORGANISM_TAXID: 9606;                                                
SOURCE  29 MOL_ID: 8;                                                           
SOURCE  30 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  31 ORGANISM_COMMON: HUMAN;                                              
SOURCE  32 ORGANISM_TAXID: 9606;                                                
SOURCE  33 MOL_ID: 9;                                                           
SOURCE  34 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  35 ORGANISM_COMMON: HUMAN;                                              
SOURCE  36 ORGANISM_TAXID: 9606;                                                
SOURCE  37 MOL_ID: 10;                                                          
SOURCE  38 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  39 ORGANISM_COMMON: HUMAN;                                              
SOURCE  40 ORGANISM_TAXID: 9606;                                                
SOURCE  41 MOL_ID: 11;                                                          
SOURCE  42 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  43 ORGANISM_COMMON: HUMAN;                                              
SOURCE  44 ORGANISM_TAXID: 9606;                                                
SOURCE  45 MOL_ID: 12;                                                          
SOURCE  46 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  47 ORGANISM_COMMON: HUMAN;                                              
SOURCE  48 ORGANISM_TAXID: 9606;                                                
SOURCE  49 MOL_ID: 13;                                                          
SOURCE  50 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  51 ORGANISM_COMMON: HUMAN;                                              
SOURCE  52 ORGANISM_TAXID: 9606;                                                
SOURCE  53 MOL_ID: 14;                                                          
SOURCE  54 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  55 ORGANISM_COMMON: HUMAN;                                              
SOURCE  56 ORGANISM_TAXID: 9606;                                                
SOURCE  57 MOL_ID: 15;                                                          
SOURCE  58 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  59 ORGANISM_COMMON: HUMAN;                                              
SOURCE  60 ORGANISM_TAXID: 9606;                                                
SOURCE  61 MOL_ID: 16;                                                          
SOURCE  62 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  63 ORGANISM_COMMON: HUMAN;                                              
SOURCE  64 ORGANISM_TAXID: 9606;                                                
SOURCE  65 MOL_ID: 17;                                                          
SOURCE  66 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  67 ORGANISM_COMMON: HUMAN;                                              
SOURCE  68 ORGANISM_TAXID: 9606;                                                
SOURCE  69 MOL_ID: 18;                                                          
SOURCE  70 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  71 ORGANISM_COMMON: HUMAN;                                              
SOURCE  72 ORGANISM_TAXID: 9606;                                                
SOURCE  73 MOL_ID: 19;                                                          
SOURCE  74 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  75 ORGANISM_COMMON: HUMAN;                                              
SOURCE  76 ORGANISM_TAXID: 9606;                                                
SOURCE  77 MOL_ID: 20;                                                          
SOURCE  78 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  79 ORGANISM_COMMON: HUMAN;                                              
SOURCE  80 ORGANISM_TAXID: 9606                                                 
KEYWDS    UBIQUITINATION, CELL CYCLE, APC/C, APC SUBUNITS, ANAPHASE PROMOTING   
KEYWDS   2 COMPLEX                                                              
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    L.CHANG,Z.ZHANG,J.YANG,S.H.MCLAUGHLIN,D.BARFORD                       
REVDAT   5   24-APR-19 4UI9    1       SCALE                                    
REVDAT   4   02-AUG-17 4UI9    1                                                
REVDAT   3   01-JUL-15 4UI9    1       JRNL                                     
REVDAT   2   24-JUN-15 4UI9    1       REMARK                                   
REVDAT   1   17-JUN-15 4UI9    0                                                
JRNL        AUTH   L.CHANG,Z.ZHANG,J.YANG,S.H.MCLAUGHLIN,D.BARFORD              
JRNL        TITL   ATOMIC STRUCTURE OF THE APC AND ITS MECHANISM OF PROTEIN     
JRNL        TITL 2 UBIQUITINATION                                               
JRNL        REF    NATURE                        V. 522   450 2015              
JRNL        REFN                   ISSN 0028-0836                               
JRNL        PMID   26083744                                                     
JRNL        DOI    10.1038/NATURE14471                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.60 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : REFMAC, RELION                            
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : 1.360                          
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.600                          
REMARK   3   NUMBER OF PARTICLES               : 202084                         
REMARK   3   CTF CORRECTION METHOD             : NULL                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 4UI9 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE.                               
REMARK 100 THE DEPOSITION ID IS D_1290063266.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : CRYO EM                           
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : HUMAN ANAPHASE-PROMOTING          
REMARK 245                                    COMPLEX                           
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.20                              
REMARK 245   SAMPLE SUPPORT DETAILS         : HOLEY CARBON                      
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 8.00                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : 09-FEB-14                      
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TECNAI F30                 
REMARK 245   DETECTOR TYPE                     : FEI FALCON II (4K X 4K)        
REMARK 245   MINIMUM DEFOCUS (NM)              : 2000.00                        
REMARK 245   MAXIMUM DEFOCUS (NM)              : 4000.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 27.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : 78000                          
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 23-MERIC                          
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 23-MERIC                   
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: K, L, M, N, O, P, R, S, T,            
REMARK 350                    AND CHAINS: U, W, X, Y                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     SER A     2                                                      
REMARK 465     ASN A     3                                                      
REMARK 465     PHE A     4                                                      
REMARK 465     TYR A     5                                                      
REMARK 465     GLU A     6                                                      
REMARK 465     GLU A     7                                                      
REMARK 465     ARG A     8                                                      
REMARK 465     THR A     9                                                      
REMARK 465     THR A    10                                                      
REMARK 465     GLY A    59                                                      
REMARK 465     SER A    60                                                      
REMARK 465     LEU A    61                                                      
REMARK 465     GLN A    62                                                      
REMARK 465     GLU A    63                                                      
REMARK 465     VAL A    64                                                      
REMARK 465     THR A    65                                                      
REMARK 465     ILE A    66                                                      
REMARK 465     HIS A    67                                                      
REMARK 465     GLU A    68                                                      
REMARK 465     LYS A    69                                                      
REMARK 465     GLN A    70                                                      
REMARK 465     GLN A   135                                                      
REMARK 465     ASP A   136                                                      
REMARK 465     LYS A   137                                                      
REMARK 465     SER A   138                                                      
REMARK 465     GLU A   139                                                      
REMARK 465     LYS A   140                                                      
REMARK 465     ALA A   141                                                      
REMARK 465     TYR A   142                                                      
REMARK 465     SER A   143                                                      
REMARK 465     SER A   144                                                      
REMARK 465     ASN A   145                                                      
REMARK 465     ALA A   193                                                      
REMARK 465     SER A   194                                                      
REMARK 465     SER A   195                                                      
REMARK 465     HIS A   196                                                      
REMARK 465     GLU A   197                                                      
REMARK 465     VAL A   198                                                      
REMARK 465     PRO A   199                                                      
REMARK 465     PRO A   200                                                      
REMARK 465     GLY A   201                                                      
REMARK 465     SER A   202                                                      
REMARK 465     PRO A   203                                                      
REMARK 465     ARG A   204                                                      
REMARK 465     GLU A   205                                                      
REMARK 465     SER A   227                                                      
REMARK 465     GLY A   228                                                      
REMARK 465     SER A   229                                                      
REMARK 465     LEU A   230                                                      
REMARK 465     PHE A   231                                                      
REMARK 465     GLY A   232                                                      
REMARK 465     SER A   233                                                      
REMARK 465     SER A   234                                                      
REMARK 465     ARG A   235                                                      
REMARK 465     ALA A   296                                                      
REMARK 465     THR A   297                                                      
REMARK 465     SER A   298                                                      
REMARK 465     SER A   299                                                      
REMARK 465     SER A   300                                                      
REMARK 465     LEU A   301                                                      
REMARK 465     THR A   302                                                      
REMARK 465     ALA A   303                                                      
REMARK 465     HIS A   304                                                      
REMARK 465     LEU A   305                                                      
REMARK 465     ARG A   306                                                      
REMARK 465     SER A   307                                                      
REMARK 465     LEU A   308                                                      
REMARK 465     SER A   309                                                      
REMARK 465     LYS A   310                                                      
REMARK 465     GLY A   311                                                      
REMARK 465     ASP A   312                                                      
REMARK 465     SER A   313                                                      
REMARK 465     PRO A   314                                                      
REMARK 465     VAL A   315                                                      
REMARK 465     THR A   316                                                      
REMARK 465     SER A   317                                                      
REMARK 465     PRO A   318                                                      
REMARK 465     PHE A   319                                                      
REMARK 465     GLN A   320                                                      
REMARK 465     ASN A   321                                                      
REMARK 465     TYR A   322                                                      
REMARK 465     SER A   323                                                      
REMARK 465     SER A   324                                                      
REMARK 465     ILE A   325                                                      
REMARK 465     HIS A   326                                                      
REMARK 465     SER A   327                                                      
REMARK 465     GLN A   328                                                      
REMARK 465     SER A   329                                                      
REMARK 465     ARG A   330                                                      
REMARK 465     SER A   331                                                      
REMARK 465     THR A   332                                                      
REMARK 465     SER A   333                                                      
REMARK 465     SER A   334                                                      
REMARK 465     PRO A   335                                                      
REMARK 465     SER A   336                                                      
REMARK 465     LEU A   337                                                      
REMARK 465     HIS A   338                                                      
REMARK 465     SER A   339                                                      
REMARK 465     ARG A   340                                                      
REMARK 465     SER A   341                                                      
REMARK 465     PRO A   342                                                      
REMARK 465     SER A   343                                                      
REMARK 465     ILE A   344                                                      
REMARK 465     SER A   345                                                      
REMARK 465     ASN A   346                                                      
REMARK 465     MET A   347                                                      
REMARK 465     ALA A   348                                                      
REMARK 465     ALA A   349                                                      
REMARK 465     LEU A   350                                                      
REMARK 465     SER A   351                                                      
REMARK 465     ARG A   352                                                      
REMARK 465     ALA A   353                                                      
REMARK 465     HIS A   354                                                      
REMARK 465     SER A   355                                                      
REMARK 465     PRO A   356                                                      
REMARK 465     ALA A   357                                                      
REMARK 465     LEU A   358                                                      
REMARK 465     GLY A   359                                                      
REMARK 465     VAL A   360                                                      
REMARK 465     HIS A   361                                                      
REMARK 465     SER A   362                                                      
REMARK 465     PHE A   363                                                      
REMARK 465     SER A   364                                                      
REMARK 465     GLY A   365                                                      
REMARK 465     VAL A   366                                                      
REMARK 465     GLN A   367                                                      
REMARK 465     ARG A   368                                                      
REMARK 465     PHE A   369                                                      
REMARK 465     ASN A   370                                                      
REMARK 465     ILE A   371                                                      
REMARK 465     SER A   372                                                      
REMARK 465     SER A   373                                                      
REMARK 465     HIS A   374                                                      
REMARK 465     ASN A   375                                                      
REMARK 465     GLN A   376                                                      
REMARK 465     SER A   377                                                      
REMARK 465     PRO A   378                                                      
REMARK 465     LYS A   379                                                      
REMARK 465     ARG A   380                                                      
REMARK 465     HIS A   381                                                      
REMARK 465     SER A   382                                                      
REMARK 465     ILE A   383                                                      
REMARK 465     SER A   384                                                      
REMARK 465     HIS A   385                                                      
REMARK 465     SER A   386                                                      
REMARK 465     PRO A   387                                                      
REMARK 465     ASN A   388                                                      
REMARK 465     SER A   389                                                      
REMARK 465     ASN A   390                                                      
REMARK 465     SER A   391                                                      
REMARK 465     ASN A   392                                                      
REMARK 465     GLY A   393                                                      
REMARK 465     SER A   394                                                      
REMARK 465     PHE A   395                                                      
REMARK 465     LEU A   396                                                      
REMARK 465     ALA A   397                                                      
REMARK 465     PRO A   398                                                      
REMARK 465     GLU A   399                                                      
REMARK 465     THR A   400                                                      
REMARK 465     GLU A   401                                                      
REMARK 465     GLU A   415                                                      
REMARK 465     THR A   416                                                      
REMARK 465     ILE A   417                                                      
REMARK 465     THR A   418                                                      
REMARK 465     ASN A   419                                                      
REMARK 465     ILE A   420                                                      
REMARK 465     ARG A   421                                                      
REMARK 465     GLU A   422                                                      
REMARK 465     LYS A   423                                                      
REMARK 465     ASN A   461                                                      
REMARK 465     ASP A   462                                                      
REMARK 465     LYS A   463                                                      
REMARK 465     LEU A   514                                                      
REMARK 465     PRO A   515                                                      
REMARK 465     ALA A   516                                                      
REMARK 465     PRO A   517                                                      
REMARK 465     SER A   518                                                      
REMARK 465     LEU A   519                                                      
REMARK 465     THR A   520                                                      
REMARK 465     MET A   521                                                      
REMARK 465     SER A   522                                                      
REMARK 465     ASN A   523                                                      
REMARK 465     THR A   524                                                      
REMARK 465     MET A   525                                                      
REMARK 465     PRO A   526                                                      
REMARK 465     ARG A   527                                                      
REMARK 465     PRO A   528                                                      
REMARK 465     SER A   529                                                      
REMARK 465     THR A   530                                                      
REMARK 465     PRO A   531                                                      
REMARK 465     LEU A   532                                                      
REMARK 465     ASP A   533                                                      
REMARK 465     GLY A   534                                                      
REMARK 465     VAL A   535                                                      
REMARK 465     SER A   536                                                      
REMARK 465     THR A   537                                                      
REMARK 465     PRO A   538                                                      
REMARK 465     LYS A   539                                                      
REMARK 465     PRO A   540                                                      
REMARK 465     LEU A   541                                                      
REMARK 465     SER A   542                                                      
REMARK 465     LYS A   543                                                      
REMARK 465     LEU A   544                                                      
REMARK 465     LEU A   545                                                      
REMARK 465     GLY A   546                                                      
REMARK 465     SER A   547                                                      
REMARK 465     LEU A   548                                                      
REMARK 465     ASP A   549                                                      
REMARK 465     GLU A   550                                                      
REMARK 465     VAL A   551                                                      
REMARK 465     VAL A   552                                                      
REMARK 465     LEU A   553                                                      
REMARK 465     LEU A   554                                                      
REMARK 465     SER A   555                                                      
REMARK 465     PRO A   556                                                      
REMARK 465     VAL A   557                                                      
REMARK 465     PRO A   558                                                      
REMARK 465     GLU A   559                                                      
REMARK 465     LEU A   560                                                      
REMARK 465     ARG A   561                                                      
REMARK 465     ASP A   562                                                      
REMARK 465     SER A   563                                                      
REMARK 465     SER A   564                                                      
REMARK 465     LYS A   565                                                      
REMARK 465     LEU A   566                                                      
REMARK 465     HIS A   567                                                      
REMARK 465     ASP A   568                                                      
REMARK 465     SER A   569                                                      
REMARK 465     LEU A   570                                                      
REMARK 465     TYR A   571                                                      
REMARK 465     ASN A   572                                                      
REMARK 465     GLU A   573                                                      
REMARK 465     ASP A   574                                                      
REMARK 465     CYS A   575                                                      
REMARK 465     THR A   576                                                      
REMARK 465     PHE A   577                                                      
REMARK 465     GLN A   578                                                      
REMARK 465     GLN A   579                                                      
REMARK 465     LEU A   580                                                      
REMARK 465     GLY A   581                                                      
REMARK 465     ASN A   671                                                      
REMARK 465     THR A   672                                                      
REMARK 465     ASP A   673                                                      
REMARK 465     ARG A   674                                                      
REMARK 465     LEU A   675                                                      
REMARK 465     ALA A   676                                                      
REMARK 465     TRP A   677                                                      
REMARK 465     THR A   678                                                      
REMARK 465     ARG A   679                                                      
REMARK 465     ASN A   680                                                      
REMARK 465     PHE A   681                                                      
REMARK 465     ASP A   682                                                      
REMARK 465     PHE A   683                                                      
REMARK 465     GLU A   684                                                      
REMARK 465     GLY A   685                                                      
REMARK 465     SER A   686                                                      
REMARK 465     LEU A   687                                                      
REMARK 465     SER A   688                                                      
REMARK 465     PRO A   689                                                      
REMARK 465     VAL A   690                                                      
REMARK 465     ILE A   691                                                      
REMARK 465     ALA A   692                                                      
REMARK 465     PRO A   693                                                      
REMARK 465     LYS A   694                                                      
REMARK 465     LYS A   695                                                      
REMARK 465     ALA A   696                                                      
REMARK 465     ARG A   697                                                      
REMARK 465     PRO A   698                                                      
REMARK 465     SER A   699                                                      
REMARK 465     GLU A   700                                                      
REMARK 465     THR A   701                                                      
REMARK 465     GLY A   702                                                      
REMARK 465     SER A   703                                                      
REMARK 465     ASP A   704                                                      
REMARK 465     ASP A   705                                                      
REMARK 465     ASP A   706                                                      
REMARK 465     TRP A   707                                                      
REMARK 465     GLU A   708                                                      
REMARK 465     TYR A   709                                                      
REMARK 465     LEU A   710                                                      
REMARK 465     LEU A   711                                                      
REMARK 465     ASN A   712                                                      
REMARK 465     SER A   713                                                      
REMARK 465     ASP A   714                                                      
REMARK 465     TYR A   715                                                      
REMARK 465     HIS A   716                                                      
REMARK 465     GLN A   717                                                      
REMARK 465     ASN A   718                                                      
REMARK 465     VAL A   719                                                      
REMARK 465     GLU A   720                                                      
REMARK 465     SER A   721                                                      
REMARK 465     HIS A   722                                                      
REMARK 465     LEU A   723                                                      
REMARK 465     LEU A   724                                                      
REMARK 465     ASN A   725                                                      
REMARK 465     ARG A   726                                                      
REMARK 465     SER A   727                                                      
REMARK 465     LEU A   728                                                      
REMARK 465     CYS A   729                                                      
REMARK 465     LEU A   730                                                      
REMARK 465     SER A   731                                                      
REMARK 465     PRO A   732                                                      
REMARK 465     SER A   733                                                      
REMARK 465     GLU A   734                                                      
REMARK 465     ALA A   735                                                      
REMARK 465     SER A   736                                                      
REMARK 465     GLN A   737                                                      
REMARK 465     MET A   738                                                      
REMARK 465     LYS A   739                                                      
REMARK 465     ASP A   740                                                      
REMARK 465     GLU A   741                                                      
REMARK 465     ASP A   742                                                      
REMARK 465     PHE A   743                                                      
REMARK 465     SER A   744                                                      
REMARK 465     GLN A   745                                                      
REMARK 465     ASN A   746                                                      
REMARK 465     LEU A   747                                                      
REMARK 465     SER A   748                                                      
REMARK 465     LEU A   749                                                      
REMARK 465     ASP A   750                                                      
REMARK 465     SER A   751                                                      
REMARK 465     SER A   752                                                      
REMARK 465     THR A   753                                                      
REMARK 465     LEU A   754                                                      
REMARK 465     LEU A   755                                                      
REMARK 465     PHE A   756                                                      
REMARK 465     ARG A   815                                                      
REMARK 465     THR A   816                                                      
REMARK 465     THR A   817                                                      
REMARK 465     GLY A   818                                                      
REMARK 465     GLN A   819                                                      
REMARK 465     VAL A   820                                                      
REMARK 465     CYS A   821                                                      
REMARK 465     THR A   822                                                      
REMARK 465     ILE A   823                                                      
REMARK 465     ASP A   824                                                      
REMARK 465     PRO A   825                                                      
REMARK 465     GLY A   826                                                      
REMARK 465     GLN A   827                                                      
REMARK 465     THR A   828                                                      
REMARK 465     GLY A   829                                                      
REMARK 465     PHE A   830                                                      
REMARK 465     MET A   831                                                      
REMARK 465     HIS A   832                                                      
REMARK 465     HIS A   833                                                      
REMARK 465     PRO A   834                                                      
REMARK 465     SER A   835                                                      
REMARK 465     PHE A   836                                                      
REMARK 465     PHE A   837                                                      
REMARK 465     THR A   838                                                      
REMARK 465     GLY A   883                                                      
REMARK 465     ASP A   884                                                      
REMARK 465     GLU A   885                                                      
REMARK 465     SER A   886                                                      
REMARK 465     LEU A   887                                                      
REMARK 465     VAL A   888                                                      
REMARK 465     SER A   889                                                      
REMARK 465     ASP A   890                                                      
REMARK 465     GLU A   891                                                      
REMARK 465     SER A   892                                                      
REMARK 465     SER A   893                                                      
REMARK 465     GLN A   894                                                      
REMARK 465     TYR A   895                                                      
REMARK 465     LEU A   896                                                      
REMARK 465     THR A   897                                                      
REMARK 465     ARG A   898                                                      
REMARK 465     ILE A   899                                                      
REMARK 465     THR A   900                                                      
REMARK 465     ILE A   901                                                      
REMARK 465     ALA A   902                                                      
REMARK 465     PRO A   903                                                      
REMARK 465     GLN A   904                                                      
REMARK 465     LYS A   905                                                      
REMARK 465     LEU A   906                                                      
REMARK 465     GLN A   907                                                      
REMARK 465     VAL A   908                                                      
REMARK 465     GLU A   909                                                      
REMARK 465     GLN A   910                                                      
REMARK 465     GLU A   911                                                      
REMARK 465     GLU A   912                                                      
REMARK 465     ASN A   913                                                      
REMARK 465     ARG A   914                                                      
REMARK 465     PHE A   915                                                      
REMARK 465     SER A   916                                                      
REMARK 465     PHE A   917                                                      
REMARK 465     ARG A   918                                                      
REMARK 465     HIS A   919                                                      
REMARK 465     SER A   920                                                      
REMARK 465     THR A   921                                                      
REMARK 465     SER A   922                                                      
REMARK 465     VAL A   923                                                      
REMARK 465     ALA A   987                                                      
REMARK 465     CYS A   988                                                      
REMARK 465     GLU A   989                                                      
REMARK 465     GLY A   990                                                      
REMARK 465     ASN A   991                                                      
REMARK 465     LEU A   992                                                      
REMARK 465     PRO A   993                                                      
REMARK 465     LYS A   994                                                      
REMARK 465     GLY A   995                                                      
REMARK 465     LYS A   996                                                      
REMARK 465     SER A   997                                                      
REMARK 465     VAL A   998                                                      
REMARK 465     LEU A   999                                                      
REMARK 465     SER A  1000                                                      
REMARK 465     SER A  1001                                                      
REMARK 465     ASP A  1002                                                      
REMARK 465     VAL A  1003                                                      
REMARK 465     PRO A  1004                                                      
REMARK 465     SER A  1005                                                      
REMARK 465     GLY A  1006                                                      
REMARK 465     THR A  1007                                                      
REMARK 465     GLU A  1008                                                      
REMARK 465     THR A  1009                                                      
REMARK 465     GLU A  1010                                                      
REMARK 465     GLU A  1011                                                      
REMARK 465     GLU A  1012                                                      
REMARK 465     ARG A  1334                                                      
REMARK 465     ARG A  1335                                                      
REMARK 465     PHE A  1336                                                      
REMARK 465     GLN A  1337                                                      
REMARK 465     THR A  1338                                                      
REMARK 465     GLY A  1339                                                      
REMARK 465     MET A  1340                                                      
REMARK 465     HIS A  1341                                                      
REMARK 465     ARG A  1342                                                      
REMARK 465     GLU A  1343                                                      
REMARK 465     LYS A  1344                                                      
REMARK 465     HIS A  1345                                                      
REMARK 465     LYS A  1346                                                      
REMARK 465     SER A  1438                                                      
REMARK 465     ILE A  1439                                                      
REMARK 465     SER A  1440                                                      
REMARK 465     LEU A  1441                                                      
REMARK 465     SER A  1442                                                      
REMARK 465     GLU A  1443                                                      
REMARK 465     ILE A  1444                                                      
REMARK 465     GLU A  1445                                                      
REMARK 465     LEU A  1446                                                      
REMARK 465     PRO A  1447                                                      
REMARK 465     CYS A  1448                                                      
REMARK 465     SER A  1449                                                      
REMARK 465     GLU A  1450                                                      
REMARK 465     ASP A  1451                                                      
REMARK 465     SER A  1681                                                      
REMARK 465     LYS A  1682                                                      
REMARK 465     GLY A  1683                                                      
REMARK 465     PRO A  1712                                                      
REMARK 465     MET A  1713                                                      
REMARK 465     GLY A  1714                                                      
REMARK 465     TRP A  1715                                                      
REMARK 465     GLN A  1716                                                      
REMARK 465     SER A  1717                                                      
REMARK 465     LEU A  1718                                                      
REMARK 465     LEU A  1719                                                      
REMARK 465     ALA A  1720                                                      
REMARK 465     GLN A  1721                                                      
REMARK 465     THR A  1722                                                      
REMARK 465     VAL A  1723                                                      
REMARK 465     ALA A  1724                                                      
REMARK 465     ASN A  1725                                                      
REMARK 465     ARG A  1726                                                      
REMARK 465     PRO A  1738                                                      
REMARK 465     GLU A  1739                                                      
REMARK 465     THR A  1740                                                      
REMARK 465     ILE A  1741                                                      
REMARK 465     GLU A  1831                                                      
REMARK 465     ARG A  1832                                                      
REMARK 465     LEU A  1833                                                      
REMARK 465     GLN A  1834                                                      
REMARK 465     ASN A  1835                                                      
REMARK 465     HIS A  1836                                                      
REMARK 465     PRO A  1837                                                      
REMARK 465     LYS A  1838                                                      
REMARK 465     ARG A  1839                                                      
REMARK 465     GLY A  1840                                                      
REMARK 465     LEU A  1841                                                      
REMARK 465     GLY A  1877                                                      
REMARK 465     GLN A  1878                                                      
REMARK 465     PRO A  1879                                                      
REMARK 465     GLN A  1901                                                      
REMARK 465     HIS A  1902                                                      
REMARK 465     LEU A  1903                                                      
REMARK 465     PRO A  1904                                                      
REMARK 465     PRO A  1905                                                      
REMARK 465     ILE A  1906                                                      
REMARK 465     GLY A  1907                                                      
REMARK 465     LEU A  1908                                                      
REMARK 465     GLU A  1909                                                      
REMARK 465     GLY A  1910                                                      
REMARK 465     PRO A  1936                                                      
REMARK 465     LEU A  1937                                                      
REMARK 465     LEU A  1938                                                      
REMARK 465     LEU A  1939                                                      
REMARK 465     GLY A  1940                                                      
REMARK 465     ASN A  1941                                                      
REMARK 465     PRO A  1942                                                      
REMARK 465     GLN A  1943                                                      
REMARK 465     PRO A  1944                                                      
REMARK 465     MET A  1945                                                      
REMARK 465     VAL A  1946                                                      
REMARK 465     MET A  1947                                                      
REMARK 465     MET C     7                                                      
REMARK 465     VAL C     8                                                      
REMARK 465     PRO C     9                                                      
REMARK 465     VAL C    10                                                      
REMARK 465     ALA C    11                                                      
REMARK 465     VAL C    12                                                      
REMARK 465     THR C    13                                                      
REMARK 465     ALA C    14                                                      
REMARK 465     ALA C    15                                                      
REMARK 465     VAL C    16                                                      
REMARK 465     ALA C    17                                                      
REMARK 465     PRO C    18                                                      
REMARK 465     VAL C    19                                                      
REMARK 465     LEU C    20                                                      
REMARK 465     SER C    21                                                      
REMARK 465     ILE C    22                                                      
REMARK 465     ASN C    23                                                      
REMARK 465     SER C    24                                                      
REMARK 465     ASP C    25                                                      
REMARK 465     GLY C   501                                                      
REMARK 465     GLU C   502                                                      
REMARK 465     ILE C   503                                                      
REMARK 465     VAL C   504                                                      
REMARK 465     GLU C   505                                                      
REMARK 465     HIS C   506                                                      
REMARK 465     LEU C   507                                                      
REMARK 465     GLU C   508                                                      
REMARK 465     ASN C   558                                                      
REMARK 465     GLN C   559                                                      
REMARK 465     GLY C   560                                                      
REMARK 465     GLU C   561                                                      
REMARK 465     THR C   562                                                      
REMARK 465     PRO C   563                                                      
REMARK 465     THR C   564                                                      
REMARK 465     THR C   565                                                      
REMARK 465     GLU C   566                                                      
REMARK 465     VAL C   567                                                      
REMARK 465     PRO C   568                                                      
REMARK 465     ALA C   569                                                      
REMARK 465     PRO C   570                                                      
REMARK 465     PHE C   571                                                      
REMARK 465     PHE C   572                                                      
REMARK 465     LEU C   573                                                      
REMARK 465     PRO C   574                                                      
REMARK 465     ALA C   575                                                      
REMARK 465     SER C   576                                                      
REMARK 465     LEU C   577                                                      
REMARK 465     SER C   578                                                      
REMARK 465     ALA C   579                                                      
REMARK 465     ASN C   580                                                      
REMARK 465     ASN C   581                                                      
REMARK 465     THR C   582                                                      
REMARK 465     PRO C   583                                                      
REMARK 465     THR C   584                                                      
REMARK 465     ARG C   585                                                      
REMARK 465     ARG C   586                                                      
REMARK 465     VAL C   587                                                      
REMARK 465     SER C   588                                                      
REMARK 465     PRO C   589                                                      
REMARK 465     LEU C   590                                                      
REMARK 465     ASN C   591                                                      
REMARK 465     LEU C   592                                                      
REMARK 465     SER C   593                                                      
REMARK 465     SER C   594                                                      
REMARK 465     VAL C   595                                                      
REMARK 465     THR C   596                                                      
REMARK 465     PRO C   597                                                      
REMARK 465     MET D     1                                                      
REMARK 465     PRO D    57                                                      
REMARK 465     ALA D    58                                                      
REMARK 465     SER D    59                                                      
REMARK 465     GLU D    60                                                      
REMARK 465     HIS D    61                                                      
REMARK 465     TYR D    62                                                      
REMARK 465     ASP D    63                                                      
REMARK 465     ASP D    64                                                      
REMARK 465     GLU D    65                                                      
REMARK 465     GLU D    66                                                      
REMARK 465     GLU D    67                                                      
REMARK 465     GLU D    68                                                      
REMARK 465     ASP D    69                                                      
REMARK 465     ASP D    70                                                      
REMARK 465     GLU D    71                                                      
REMARK 465     ASP D    72                                                      
REMARK 465     ASP D    73                                                      
REMARK 465     GLU D    74                                                      
REMARK 465     ASP D    75                                                      
REMARK 465     SER D    76                                                      
REMARK 465     GLU D    77                                                      
REMARK 465     GLU D    78                                                      
REMARK 465     ASP D    79                                                      
REMARK 465     SER D    80                                                      
REMARK 465     GLU D    81                                                      
REMARK 465     ASP D    82                                                      
REMARK 465     ASP D    83                                                      
REMARK 465     GLU D    84                                                      
REMARK 465     ASP D    85                                                      
REMARK 465     MET D    86                                                      
REMARK 465     GLN D    87                                                      
REMARK 465     ASP D    88                                                      
REMARK 465     MET D    89                                                      
REMARK 465     ASP D    90                                                      
REMARK 465     GLU D    91                                                      
REMARK 465     MET D    92                                                      
REMARK 465     ASN D    93                                                      
REMARK 465     ASP D    94                                                      
REMARK 465     TYR D    95                                                      
REMARK 465     ASN D    96                                                      
REMARK 465     GLU D    97                                                      
REMARK 465     SER D    98                                                      
REMARK 465     PRO D    99                                                      
REMARK 465     ASP D   100                                                      
REMARK 465     ASP D   101                                                      
REMARK 465     GLY D   102                                                      
REMARK 465     GLU D   103                                                      
REMARK 465     VAL D   104                                                      
REMARK 465     ASN D   105                                                      
REMARK 465     GLU D   106                                                      
REMARK 465     VAL D   107                                                      
REMARK 465     ASP D   108                                                      
REMARK 465     MET D   109                                                      
REMARK 465     GLU D   110                                                      
REMARK 465     GLY D   111                                                      
REMARK 465     ASN D   112                                                      
REMARK 465     GLU D   113                                                      
REMARK 465     GLN D   114                                                      
REMARK 465     ASP D   115                                                      
REMARK 465     GLN D   116                                                      
REMARK 465     ASP D   117                                                      
REMARK 465     GLN D   118                                                      
REMARK 465     TRP D   119                                                      
REMARK 465     MET D   120                                                      
REMARK 465     ILE D   121                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ALA E     2                                                      
REMARK 465     ALA E     3                                                      
REMARK 465     SER E     4                                                      
REMARK 465     SER E     5                                                      
REMARK 465     SER E     6                                                      
REMARK 465     SER E     7                                                      
REMARK 465     SER E     8                                                      
REMARK 465     SER E     9                                                      
REMARK 465     ALA E    10                                                      
REMARK 465     GLY E    11                                                      
REMARK 465     GLY E    12                                                      
REMARK 465     VAL E    13                                                      
REMARK 465     SER E    14                                                      
REMARK 465     GLY E    15                                                      
REMARK 465     SER E    16                                                      
REMARK 465     SER E    17                                                      
REMARK 465     VAL E    18                                                      
REMARK 465     THR E    19                                                      
REMARK 465     GLY E    20                                                      
REMARK 465     SER E    21                                                      
REMARK 465     GLY E    22                                                      
REMARK 465     PHE E    23                                                      
REMARK 465     SER E    24                                                      
REMARK 465     VAL E    25                                                      
REMARK 465     SER E    26                                                      
REMARK 465     ASP E    27                                                      
REMARK 465     LEU E    28                                                      
REMARK 465     ALA E    29                                                      
REMARK 465     PRO E    30                                                      
REMARK 465     PRO E    31                                                      
REMARK 465     ARG E    32                                                      
REMARK 465     LYS E    33                                                      
REMARK 465     ALA E    34                                                      
REMARK 465     LEU E    35                                                      
REMARK 465     PHE E    36                                                      
REMARK 465     THR E    37                                                      
REMARK 465     TYR E    38                                                      
REMARK 465     PRO E    39                                                      
REMARK 465     LYS E    40                                                      
REMARK 465     GLY E    41                                                      
REMARK 465     ALA E    42                                                      
REMARK 465     GLY E    43                                                      
REMARK 465     GLU E    44                                                      
REMARK 465     MET E    45                                                      
REMARK 465     LEU E    46                                                      
REMARK 465     GLU E    47                                                      
REMARK 465     ASP E    48                                                      
REMARK 465     GLY E    49                                                      
REMARK 465     SER E    50                                                      
REMARK 465     GLU E    51                                                      
REMARK 465     SER E   108                                                      
REMARK 465     SER E   109                                                      
REMARK 465     GLY E   110                                                      
REMARK 465     MET F     1                                                      
REMARK 465     THR F     2                                                      
REMARK 465     VAL F     3                                                      
REMARK 465     LEU F     4                                                      
REMARK 465     THR F   171                                                      
REMARK 465     SER F   172                                                      
REMARK 465     LEU F   173                                                      
REMARK 465     GLN F   174                                                      
REMARK 465     ASN F   175                                                      
REMARK 465     PHE F   176                                                      
REMARK 465     SER F   177                                                      
REMARK 465     ASN F   178                                                      
REMARK 465     CYS F   179                                                      
REMARK 465     LEU F   180                                                      
REMARK 465     PRO F   181                                                      
REMARK 465     ASN F   182                                                      
REMARK 465     SER F   183                                                      
REMARK 465     CYS F   184                                                      
REMARK 465     THR F   185                                                      
REMARK 465     THR F   186                                                      
REMARK 465     GLN F   187                                                      
REMARK 465     VAL F   188                                                      
REMARK 465     PRO F   189                                                      
REMARK 465     ASN F   190                                                      
REMARK 465     HIS F   191                                                      
REMARK 465     SER F   192                                                      
REMARK 465     LEU F   193                                                      
REMARK 465     SER F   194                                                      
REMARK 465     HIS F   195                                                      
REMARK 465     ARG F   196                                                      
REMARK 465     GLN F   197                                                      
REMARK 465     PRO F   198                                                      
REMARK 465     GLU F   199                                                      
REMARK 465     THR F   200                                                      
REMARK 465     VAL F   201                                                      
REMARK 465     LEU F   202                                                      
REMARK 465     THR F   203                                                      
REMARK 465     GLU F   204                                                      
REMARK 465     THR F   205                                                      
REMARK 465     PRO F   206                                                      
REMARK 465     GLN F   207                                                      
REMARK 465     ASP F   208                                                      
REMARK 465     THR F   209                                                      
REMARK 465     ILE F   210                                                      
REMARK 465     GLU F   211                                                      
REMARK 465     LEU F   212                                                      
REMARK 465     ASN F   213                                                      
REMARK 465     ARG F   214                                                      
REMARK 465     LEU F   215                                                      
REMARK 465     ASN F   216                                                      
REMARK 465     LEU F   217                                                      
REMARK 465     GLU F   218                                                      
REMARK 465     SER F   219                                                      
REMARK 465     SER F   220                                                      
REMARK 465     ASN F   221                                                      
REMARK 465     SER F   222                                                      
REMARK 465     LYS F   223                                                      
REMARK 465     TYR F   224                                                      
REMARK 465     SER F   225                                                      
REMARK 465     LEU F   226                                                      
REMARK 465     ASN F   227                                                      
REMARK 465     THR F   228                                                      
REMARK 465     ASP F   229                                                      
REMARK 465     SER F   230                                                      
REMARK 465     SER F   231                                                      
REMARK 465     VAL F   232                                                      
REMARK 465     SER F   233                                                      
REMARK 465     TYR F   234                                                      
REMARK 465     ILE F   235                                                      
REMARK 465     ASP F   236                                                      
REMARK 465     SER F   237                                                      
REMARK 465     ALA F   238                                                      
REMARK 465     VAL F   239                                                      
REMARK 465     ILE F   240                                                      
REMARK 465     SER F   241                                                      
REMARK 465     PRO F   242                                                      
REMARK 465     ASP F   243                                                      
REMARK 465     THR F   244                                                      
REMARK 465     VAL F   245                                                      
REMARK 465     PRO F   246                                                      
REMARK 465     LEU F   247                                                      
REMARK 465     GLY F   248                                                      
REMARK 465     THR F   249                                                      
REMARK 465     GLY F   250                                                      
REMARK 465     THR F   251                                                      
REMARK 465     SER F   252                                                      
REMARK 465     ILE F   253                                                      
REMARK 465     LEU F   254                                                      
REMARK 465     SER F   255                                                      
REMARK 465     LYS F   256                                                      
REMARK 465     GLN F   257                                                      
REMARK 465     VAL F   258                                                      
REMARK 465     GLN F   259                                                      
REMARK 465     ASN F   260                                                      
REMARK 465     LYS F   261                                                      
REMARK 465     PRO F   262                                                      
REMARK 465     LYS F   263                                                      
REMARK 465     THR F   264                                                      
REMARK 465     GLY F   265                                                      
REMARK 465     ARG F   266                                                      
REMARK 465     SER F   267                                                      
REMARK 465     LEU F   268                                                      
REMARK 465     LEU F   269                                                      
REMARK 465     GLY F   270                                                      
REMARK 465     GLY F   271                                                      
REMARK 465     PRO F   272                                                      
REMARK 465     ALA F   273                                                      
REMARK 465     ALA F   274                                                      
REMARK 465     LEU F   275                                                      
REMARK 465     SER F   276                                                      
REMARK 465     PRO F   277                                                      
REMARK 465     LEU F   278                                                      
REMARK 465     THR F   279                                                      
REMARK 465     PRO F   280                                                      
REMARK 465     SER F   281                                                      
REMARK 465     PHE F   282                                                      
REMARK 465     GLY F   283                                                      
REMARK 465     ILE F   284                                                      
REMARK 465     LEU F   285                                                      
REMARK 465     PRO F   286                                                      
REMARK 465     LEU F   287                                                      
REMARK 465     GLU F   288                                                      
REMARK 465     THR F   289                                                      
REMARK 465     PRO F   290                                                      
REMARK 465     SER F   291                                                      
REMARK 465     PRO F   292                                                      
REMARK 465     GLY F   293                                                      
REMARK 465     ASP F   294                                                      
REMARK 465     GLY F   295                                                      
REMARK 465     SER F   296                                                      
REMARK 465     TYR F   297                                                      
REMARK 465     LEU F   298                                                      
REMARK 465     GLN F   299                                                      
REMARK 465     ASN F   300                                                      
REMARK 465     TYR F   301                                                      
REMARK 465     THR F   302                                                      
REMARK 465     ASN F   303                                                      
REMARK 465     THR F   304                                                      
REMARK 465     PRO F   305                                                      
REMARK 465     PRO F   306                                                      
REMARK 465     VAL F   307                                                      
REMARK 465     ILE F   308                                                      
REMARK 465     ASP F   309                                                      
REMARK 465     VAL F   310                                                      
REMARK 465     PRO F   311                                                      
REMARK 465     SER F   312                                                      
REMARK 465     THR F   313                                                      
REMARK 465     GLY F   314                                                      
REMARK 465     ALA F   315                                                      
REMARK 465     PRO F   316                                                      
REMARK 465     SER F   317                                                      
REMARK 465     LYS F   318                                                      
REMARK 465     LYS F   319                                                      
REMARK 465     SER F   320                                                      
REMARK 465     VAL F   321                                                      
REMARK 465     ALA F   322                                                      
REMARK 465     ARG F   323                                                      
REMARK 465     ILE F   324                                                      
REMARK 465     GLY F   325                                                      
REMARK 465     GLN F   326                                                      
REMARK 465     THR F   327                                                      
REMARK 465     GLY F   328                                                      
REMARK 465     THR F   329                                                      
REMARK 465     LYS F   330                                                      
REMARK 465     SER F   331                                                      
REMARK 465     VAL F   332                                                      
REMARK 465     PHE F   333                                                      
REMARK 465     SER F   334                                                      
REMARK 465     GLN F   335                                                      
REMARK 465     SER F   336                                                      
REMARK 465     GLY F   337                                                      
REMARK 465     ASN F   338                                                      
REMARK 465     SER F   339                                                      
REMARK 465     ARG F   340                                                      
REMARK 465     GLU F   341                                                      
REMARK 465     VAL F   342                                                      
REMARK 465     THR F   343                                                      
REMARK 465     PRO F   344                                                      
REMARK 465     ILE F   345                                                      
REMARK 465     LEU F   346                                                      
REMARK 465     ALA F   347                                                      
REMARK 465     GLN F   348                                                      
REMARK 465     THR F   349                                                      
REMARK 465     GLN F   350                                                      
REMARK 465     SER F   351                                                      
REMARK 465     SER F   352                                                      
REMARK 465     GLY F   353                                                      
REMARK 465     PRO F   354                                                      
REMARK 465     GLN F   355                                                      
REMARK 465     THR F   356                                                      
REMARK 465     SER F   357                                                      
REMARK 465     THR F   358                                                      
REMARK 465     THR F   359                                                      
REMARK 465     PRO F   360                                                      
REMARK 465     GLN F   361                                                      
REMARK 465     VAL F   362                                                      
REMARK 465     LEU F   363                                                      
REMARK 465     SER F   364                                                      
REMARK 465     PRO F   365                                                      
REMARK 465     THR F   366                                                      
REMARK 465     ILE F   367                                                      
REMARK 465     THR F   368                                                      
REMARK 465     SER F   369                                                      
REMARK 465     PRO F   370                                                      
REMARK 465     PRO F   371                                                      
REMARK 465     ASN F   372                                                      
REMARK 465     ALA F   373                                                      
REMARK 465     LEU F   374                                                      
REMARK 465     PRO F   375                                                      
REMARK 465     ARG F   376                                                      
REMARK 465     ARG F   377                                                      
REMARK 465     SER F   378                                                      
REMARK 465     SER F   379                                                      
REMARK 465     ARG F   380                                                      
REMARK 465     LEU F   381                                                      
REMARK 465     PHE F   382                                                      
REMARK 465     THR F   383                                                      
REMARK 465     SER F   384                                                      
REMARK 465     ASP F   385                                                      
REMARK 465     SER F   386                                                      
REMARK 465     SER F   387                                                      
REMARK 465     THR F   388                                                      
REMARK 465     THR F   389                                                      
REMARK 465     LYS F   390                                                      
REMARK 465     GLU F   391                                                      
REMARK 465     ASN F   392                                                      
REMARK 465     SER F   393                                                      
REMARK 465     LYS F   394                                                      
REMARK 465     LYS F   395                                                      
REMARK 465     LEU F   396                                                      
REMARK 465     LYS F   397                                                      
REMARK 465     MET F   398                                                      
REMARK 465     LYS F   399                                                      
REMARK 465     PHE F   400                                                      
REMARK 465     PRO F   401                                                      
REMARK 465     PRO F   402                                                      
REMARK 465     GLU F   403                                                      
REMARK 465     ILE F   404                                                      
REMARK 465     PRO F   405                                                      
REMARK 465     ASN F   406                                                      
REMARK 465     ARG F   407                                                      
REMARK 465     LYS F   408                                                      
REMARK 465     THR F   409                                                      
REMARK 465     LYS F   410                                                      
REMARK 465     SER F   411                                                      
REMARK 465     LYS F   412                                                      
REMARK 465     THR F   413                                                      
REMARK 465     ASN F   414                                                      
REMARK 465     LYS F   415                                                      
REMARK 465     GLY F   416                                                      
REMARK 465     GLY F   417                                                      
REMARK 465     ILE F   418                                                      
REMARK 465     THR F   419                                                      
REMARK 465     GLN F   420                                                      
REMARK 465     PRO F   421                                                      
REMARK 465     ASN F   422                                                      
REMARK 465     ILE F   423                                                      
REMARK 465     ASN F   424                                                      
REMARK 465     ASP F   425                                                      
REMARK 465     SER F   426                                                      
REMARK 465     LEU F   427                                                      
REMARK 465     GLU F   428                                                      
REMARK 465     ILE F   429                                                      
REMARK 465     THR F   430                                                      
REMARK 465     LYS F   431                                                      
REMARK 465     LEU F   432                                                      
REMARK 465     ASP F   433                                                      
REMARK 465     SER F   434                                                      
REMARK 465     SER F   435                                                      
REMARK 465     ILE F   436                                                      
REMARK 465     ILE F   437                                                      
REMARK 465     SER F   438                                                      
REMARK 465     GLU F   439                                                      
REMARK 465     GLY F   440                                                      
REMARK 465     LYS F   441                                                      
REMARK 465     ILE F   442                                                      
REMARK 465     SER F   443                                                      
REMARK 465     THR F   444                                                      
REMARK 465     ILE F   445                                                      
REMARK 465     THR F   446                                                      
REMARK 465     PRO F   447                                                      
REMARK 465     GLN F   448                                                      
REMARK 465     ILE F   449                                                      
REMARK 465     GLN F   450                                                      
REMARK 465     TYR F   820                                                      
REMARK 465     LEU F   821                                                      
REMARK 465     PRO F   822                                                      
REMARK 465     ASP F   823                                                      
REMARK 465     ASP F   824                                                      
REMARK 465     GLU F   825                                                      
REMARK 465     GLU F   826                                                      
REMARK 465     PRO F   827                                                      
REMARK 465     ILE F   828                                                      
REMARK 465     THR F   829                                                      
REMARK 465     GLN F   830                                                      
REMARK 465     GLU F   831                                                      
REMARK 465     GLU F   832                                                      
REMARK 465     GLN F   833                                                      
REMARK 465     ILE F   834                                                      
REMARK 465     MET F   835                                                      
REMARK 465     GLY F   836                                                      
REMARK 465     THR F   837                                                      
REMARK 465     ASP F   838                                                      
REMARK 465     GLU F   839                                                      
REMARK 465     SER F   840                                                      
REMARK 465     GLN F   841                                                      
REMARK 465     GLU F   842                                                      
REMARK 465     SER F   843                                                      
REMARK 465     SER F   844                                                      
REMARK 465     MET F   845                                                      
REMARK 465     THR F   846                                                      
REMARK 465     ASP F   847                                                      
REMARK 465     ALA F   848                                                      
REMARK 465     ASP F   849                                                      
REMARK 465     ASP F   850                                                      
REMARK 465     THR F   851                                                      
REMARK 465     GLN F   852                                                      
REMARK 465     LEU F   853                                                      
REMARK 465     HIS F   854                                                      
REMARK 465     ALA F   855                                                      
REMARK 465     ALA F   856                                                      
REMARK 465     GLU F   857                                                      
REMARK 465     SER F   858                                                      
REMARK 465     ASP F   859                                                      
REMARK 465     GLU F   860                                                      
REMARK 465     PHE F   861                                                      
REMARK 465     LEU G    26                                                      
REMARK 465     GLU G    27                                                      
REMARK 465     THR G    28                                                      
REMARK 465     ARG G    29                                                      
REMARK 465     LYS G    30                                                      
REMARK 465     LYS G    31                                                      
REMARK 465     GLN G    32                                                      
REMARK 465     LYS G    33                                                      
REMARK 465     GLU G    34                                                      
REMARK 465     ASP G    35                                                      
REMARK 465     VAL G    36                                                      
REMARK 465     GLU G    37                                                      
REMARK 465     VAL G    38                                                      
REMARK 465     VAL G    39                                                      
REMARK 465     GLY G    40                                                      
REMARK 465     GLY G    41                                                      
REMARK 465     SER G    42                                                      
REMARK 465     ASP G    43                                                      
REMARK 465     GLY G    44                                                      
REMARK 465     GLU G    45                                                      
REMARK 465     GLY G    46                                                      
REMARK 465     ALA G    47                                                      
REMARK 465     ILE G    48                                                      
REMARK 465     GLY G    49                                                      
REMARK 465     LEU G    50                                                      
REMARK 465     SER G    51                                                      
REMARK 465     SER G    52                                                      
REMARK 465     ASP G    53                                                      
REMARK 465     PRO G    54                                                      
REMARK 465     LYS G    55                                                      
REMARK 465     SER G    56                                                      
REMARK 465     ARG G    57                                                      
REMARK 465     GLU G    58                                                      
REMARK 465     GLN G    59                                                      
REMARK 465     MET G    60                                                      
REMARK 465     ILE G    61                                                      
REMARK 465     ASN G    62                                                      
REMARK 465     ASP G    63                                                      
REMARK 465     ARG G    64                                                      
REMARK 465     ILE G    65                                                      
REMARK 465     GLY G    66                                                      
REMARK 465     TYR G    67                                                      
REMARK 465     LYS G    68                                                      
REMARK 465     PRO G    69                                                      
REMARK 465     GLN G    70                                                      
REMARK 465     PRO G    71                                                      
REMARK 465     LYS G    72                                                      
REMARK 465     PRO G    73                                                      
REMARK 465     ASN G    74                                                      
REMARK 465     ASN G    75                                                      
REMARK 465     ARG G    76                                                      
REMARK 465     SER G    77                                                      
REMARK 465     SER G    78                                                      
REMARK 465     GLN G    79                                                      
REMARK 465     PHE G    80                                                      
REMARK 465     GLY G    81                                                      
REMARK 465     SER G    82                                                      
REMARK 465     LEU G    83                                                      
REMARK 465     GLU G    84                                                      
REMARK 465     PHE G    85                                                      
REMARK 465     MET H     1                                                      
REMARK 465     THR H     2                                                      
REMARK 465     VAL H     3                                                      
REMARK 465     LEU H     4                                                      
REMARK 465     THR H   171                                                      
REMARK 465     SER H   172                                                      
REMARK 465     LEU H   173                                                      
REMARK 465     GLN H   174                                                      
REMARK 465     ASN H   175                                                      
REMARK 465     PHE H   176                                                      
REMARK 465     SER H   177                                                      
REMARK 465     ASN H   178                                                      
REMARK 465     CYS H   179                                                      
REMARK 465     LEU H   180                                                      
REMARK 465     PRO H   181                                                      
REMARK 465     ASN H   182                                                      
REMARK 465     SER H   183                                                      
REMARK 465     CYS H   184                                                      
REMARK 465     THR H   185                                                      
REMARK 465     THR H   186                                                      
REMARK 465     GLN H   187                                                      
REMARK 465     VAL H   188                                                      
REMARK 465     PRO H   189                                                      
REMARK 465     ASN H   190                                                      
REMARK 465     HIS H   191                                                      
REMARK 465     SER H   192                                                      
REMARK 465     LEU H   193                                                      
REMARK 465     SER H   194                                                      
REMARK 465     HIS H   195                                                      
REMARK 465     ARG H   196                                                      
REMARK 465     GLN H   197                                                      
REMARK 465     PRO H   198                                                      
REMARK 465     GLU H   199                                                      
REMARK 465     THR H   200                                                      
REMARK 465     VAL H   201                                                      
REMARK 465     LEU H   202                                                      
REMARK 465     THR H   203                                                      
REMARK 465     GLU H   204                                                      
REMARK 465     THR H   205                                                      
REMARK 465     PRO H   206                                                      
REMARK 465     GLN H   207                                                      
REMARK 465     ASP H   208                                                      
REMARK 465     THR H   209                                                      
REMARK 465     ILE H   210                                                      
REMARK 465     GLU H   211                                                      
REMARK 465     LEU H   212                                                      
REMARK 465     ASN H   213                                                      
REMARK 465     ARG H   214                                                      
REMARK 465     LEU H   215                                                      
REMARK 465     ASN H   216                                                      
REMARK 465     LEU H   217                                                      
REMARK 465     GLU H   218                                                      
REMARK 465     SER H   219                                                      
REMARK 465     SER H   220                                                      
REMARK 465     ASN H   221                                                      
REMARK 465     SER H   222                                                      
REMARK 465     LYS H   223                                                      
REMARK 465     TYR H   224                                                      
REMARK 465     SER H   225                                                      
REMARK 465     LEU H   226                                                      
REMARK 465     ASN H   227                                                      
REMARK 465     THR H   228                                                      
REMARK 465     ASP H   229                                                      
REMARK 465     SER H   230                                                      
REMARK 465     SER H   231                                                      
REMARK 465     VAL H   232                                                      
REMARK 465     SER H   233                                                      
REMARK 465     TYR H   234                                                      
REMARK 465     ILE H   235                                                      
REMARK 465     ASP H   236                                                      
REMARK 465     SER H   237                                                      
REMARK 465     ALA H   238                                                      
REMARK 465     VAL H   239                                                      
REMARK 465     ILE H   240                                                      
REMARK 465     SER H   241                                                      
REMARK 465     PRO H   242                                                      
REMARK 465     ASP H   243                                                      
REMARK 465     THR H   244                                                      
REMARK 465     VAL H   245                                                      
REMARK 465     PRO H   246                                                      
REMARK 465     LEU H   247                                                      
REMARK 465     GLY H   248                                                      
REMARK 465     THR H   249                                                      
REMARK 465     GLY H   250                                                      
REMARK 465     THR H   251                                                      
REMARK 465     SER H   252                                                      
REMARK 465     ILE H   253                                                      
REMARK 465     LEU H   254                                                      
REMARK 465     SER H   255                                                      
REMARK 465     LYS H   256                                                      
REMARK 465     GLN H   257                                                      
REMARK 465     VAL H   258                                                      
REMARK 465     GLN H   259                                                      
REMARK 465     ASN H   260                                                      
REMARK 465     LYS H   261                                                      
REMARK 465     PRO H   262                                                      
REMARK 465     LYS H   263                                                      
REMARK 465     THR H   264                                                      
REMARK 465     GLY H   265                                                      
REMARK 465     ARG H   266                                                      
REMARK 465     SER H   267                                                      
REMARK 465     LEU H   268                                                      
REMARK 465     LEU H   269                                                      
REMARK 465     GLY H   270                                                      
REMARK 465     GLY H   271                                                      
REMARK 465     PRO H   272                                                      
REMARK 465     ALA H   273                                                      
REMARK 465     ALA H   274                                                      
REMARK 465     LEU H   275                                                      
REMARK 465     SER H   276                                                      
REMARK 465     PRO H   277                                                      
REMARK 465     LEU H   278                                                      
REMARK 465     THR H   279                                                      
REMARK 465     PRO H   280                                                      
REMARK 465     SER H   281                                                      
REMARK 465     PHE H   282                                                      
REMARK 465     GLY H   283                                                      
REMARK 465     ILE H   284                                                      
REMARK 465     LEU H   285                                                      
REMARK 465     PRO H   286                                                      
REMARK 465     LEU H   287                                                      
REMARK 465     GLU H   288                                                      
REMARK 465     THR H   289                                                      
REMARK 465     PRO H   290                                                      
REMARK 465     SER H   291                                                      
REMARK 465     PRO H   292                                                      
REMARK 465     GLY H   293                                                      
REMARK 465     ASP H   294                                                      
REMARK 465     GLY H   295                                                      
REMARK 465     SER H   296                                                      
REMARK 465     TYR H   297                                                      
REMARK 465     LEU H   298                                                      
REMARK 465     GLN H   299                                                      
REMARK 465     ASN H   300                                                      
REMARK 465     TYR H   301                                                      
REMARK 465     THR H   302                                                      
REMARK 465     ASN H   303                                                      
REMARK 465     THR H   304                                                      
REMARK 465     PRO H   305                                                      
REMARK 465     PRO H   306                                                      
REMARK 465     VAL H   307                                                      
REMARK 465     ILE H   308                                                      
REMARK 465     ASP H   309                                                      
REMARK 465     VAL H   310                                                      
REMARK 465     PRO H   311                                                      
REMARK 465     SER H   312                                                      
REMARK 465     THR H   313                                                      
REMARK 465     GLY H   314                                                      
REMARK 465     ALA H   315                                                      
REMARK 465     PRO H   316                                                      
REMARK 465     SER H   317                                                      
REMARK 465     LYS H   318                                                      
REMARK 465     LYS H   319                                                      
REMARK 465     SER H   320                                                      
REMARK 465     VAL H   321                                                      
REMARK 465     ALA H   322                                                      
REMARK 465     ARG H   323                                                      
REMARK 465     ILE H   324                                                      
REMARK 465     GLY H   325                                                      
REMARK 465     GLN H   326                                                      
REMARK 465     THR H   327                                                      
REMARK 465     GLY H   328                                                      
REMARK 465     THR H   329                                                      
REMARK 465     LYS H   330                                                      
REMARK 465     SER H   331                                                      
REMARK 465     VAL H   332                                                      
REMARK 465     PHE H   333                                                      
REMARK 465     SER H   334                                                      
REMARK 465     GLN H   335                                                      
REMARK 465     SER H   336                                                      
REMARK 465     GLY H   337                                                      
REMARK 465     ASN H   338                                                      
REMARK 465     SER H   339                                                      
REMARK 465     ARG H   340                                                      
REMARK 465     GLU H   341                                                      
REMARK 465     VAL H   342                                                      
REMARK 465     THR H   343                                                      
REMARK 465     PRO H   344                                                      
REMARK 465     ILE H   345                                                      
REMARK 465     LEU H   346                                                      
REMARK 465     ALA H   347                                                      
REMARK 465     GLN H   348                                                      
REMARK 465     THR H   349                                                      
REMARK 465     GLN H   350                                                      
REMARK 465     SER H   351                                                      
REMARK 465     SER H   352                                                      
REMARK 465     GLY H   353                                                      
REMARK 465     PRO H   354                                                      
REMARK 465     GLN H   355                                                      
REMARK 465     THR H   356                                                      
REMARK 465     SER H   357                                                      
REMARK 465     THR H   358                                                      
REMARK 465     THR H   359                                                      
REMARK 465     PRO H   360                                                      
REMARK 465     GLN H   361                                                      
REMARK 465     VAL H   362                                                      
REMARK 465     LEU H   363                                                      
REMARK 465     SER H   364                                                      
REMARK 465     PRO H   365                                                      
REMARK 465     THR H   366                                                      
REMARK 465     ILE H   367                                                      
REMARK 465     THR H   368                                                      
REMARK 465     SER H   369                                                      
REMARK 465     PRO H   370                                                      
REMARK 465     PRO H   371                                                      
REMARK 465     ASN H   372                                                      
REMARK 465     ALA H   373                                                      
REMARK 465     LEU H   374                                                      
REMARK 465     PRO H   375                                                      
REMARK 465     ARG H   376                                                      
REMARK 465     ARG H   377                                                      
REMARK 465     SER H   378                                                      
REMARK 465     SER H   379                                                      
REMARK 465     ARG H   380                                                      
REMARK 465     LEU H   381                                                      
REMARK 465     PHE H   382                                                      
REMARK 465     THR H   383                                                      
REMARK 465     SER H   384                                                      
REMARK 465     ASP H   385                                                      
REMARK 465     SER H   386                                                      
REMARK 465     SER H   387                                                      
REMARK 465     THR H   388                                                      
REMARK 465     THR H   389                                                      
REMARK 465     LYS H   390                                                      
REMARK 465     GLU H   391                                                      
REMARK 465     ASN H   392                                                      
REMARK 465     SER H   393                                                      
REMARK 465     LYS H   394                                                      
REMARK 465     LYS H   395                                                      
REMARK 465     LEU H   396                                                      
REMARK 465     LYS H   397                                                      
REMARK 465     MET H   398                                                      
REMARK 465     LYS H   399                                                      
REMARK 465     PHE H   400                                                      
REMARK 465     PRO H   401                                                      
REMARK 465     PRO H   402                                                      
REMARK 465     GLU H   403                                                      
REMARK 465     ILE H   404                                                      
REMARK 465     PRO H   405                                                      
REMARK 465     ASN H   406                                                      
REMARK 465     ARG H   407                                                      
REMARK 465     LYS H   408                                                      
REMARK 465     THR H   409                                                      
REMARK 465     LYS H   410                                                      
REMARK 465     SER H   411                                                      
REMARK 465     LYS H   412                                                      
REMARK 465     THR H   413                                                      
REMARK 465     ASN H   414                                                      
REMARK 465     LYS H   415                                                      
REMARK 465     GLY H   416                                                      
REMARK 465     GLY H   417                                                      
REMARK 465     ILE H   418                                                      
REMARK 465     THR H   419                                                      
REMARK 465     GLN H   420                                                      
REMARK 465     PRO H   421                                                      
REMARK 465     ASN H   422                                                      
REMARK 465     ILE H   423                                                      
REMARK 465     ASN H   424                                                      
REMARK 465     ASP H   425                                                      
REMARK 465     SER H   426                                                      
REMARK 465     LEU H   427                                                      
REMARK 465     GLU H   428                                                      
REMARK 465     ILE H   429                                                      
REMARK 465     THR H   430                                                      
REMARK 465     LYS H   431                                                      
REMARK 465     LEU H   432                                                      
REMARK 465     ASP H   433                                                      
REMARK 465     SER H   434                                                      
REMARK 465     SER H   435                                                      
REMARK 465     ILE H   436                                                      
REMARK 465     ILE H   437                                                      
REMARK 465     SER H   438                                                      
REMARK 465     GLU H   439                                                      
REMARK 465     GLY H   440                                                      
REMARK 465     LYS H   441                                                      
REMARK 465     ILE H   442                                                      
REMARK 465     SER H   443                                                      
REMARK 465     THR H   444                                                      
REMARK 465     ILE H   445                                                      
REMARK 465     THR H   446                                                      
REMARK 465     PRO H   447                                                      
REMARK 465     GLN H   448                                                      
REMARK 465     ILE H   449                                                      
REMARK 465     GLN H   450                                                      
REMARK 465     PRO H   772                                                      
REMARK 465     LYS H   773                                                      
REMARK 465     GLY H   774                                                      
REMARK 465     ALA H   775                                                      
REMARK 465     ASN H   776                                                      
REMARK 465     ASN H   777                                                      
REMARK 465     GLN H   778                                                      
REMARK 465     ILE H   779                                                      
REMARK 465     LYS H   780                                                      
REMARK 465     GLU H   781                                                      
REMARK 465     ALA H   782                                                      
REMARK 465     ILE H   783                                                      
REMARK 465     ASP H   784                                                      
REMARK 465     LYS H   785                                                      
REMARK 465     ARG H   786                                                      
REMARK 465     TYR H   787                                                      
REMARK 465     LEU H   788                                                      
REMARK 465     PRO H   789                                                      
REMARK 465     ASP H   790                                                      
REMARK 465     ASP H   791                                                      
REMARK 465     GLU H   792                                                      
REMARK 465     GLU H   793                                                      
REMARK 465     PRO H   794                                                      
REMARK 465     ILE H   795                                                      
REMARK 465     THR H   796                                                      
REMARK 465     GLN H   797                                                      
REMARK 465     GLU H   798                                                      
REMARK 465     GLU H   799                                                      
REMARK 465     GLN H   800                                                      
REMARK 465     ILE H   801                                                      
REMARK 465     MET H   802                                                      
REMARK 465     GLY H   803                                                      
REMARK 465     THR H   804                                                      
REMARK 465     ASP H   805                                                      
REMARK 465     GLU H   806                                                      
REMARK 465     SER H   807                                                      
REMARK 465     GLN H   808                                                      
REMARK 465     GLU H   809                                                      
REMARK 465     SER H   810                                                      
REMARK 465     SER H   811                                                      
REMARK 465     MET H   812                                                      
REMARK 465     THR H   813                                                      
REMARK 465     ASP H   814                                                      
REMARK 465     ALA H   815                                                      
REMARK 465     ASP H   816                                                      
REMARK 465     ASP H   817                                                      
REMARK 465     THR H   818                                                      
REMARK 465     GLN H   819                                                      
REMARK 465     LEU H   820                                                      
REMARK 465     HIS H   821                                                      
REMARK 465     ALA H   822                                                      
REMARK 465     ALA H   823                                                      
REMARK 465     GLU H   824                                                      
REMARK 465     SER H   825                                                      
REMARK 465     ASP H   826                                                      
REMARK 465     GLU H   827                                                      
REMARK 465     PHE H   828                                                      
REMARK 465     MET I     1                                                      
REMARK 465     LEU I     2                                                      
REMARK 465     ARG I     3                                                      
REMARK 465     PHE I     4                                                      
REMARK 465     PRO I     5                                                      
REMARK 465     ASN I   130                                                      
REMARK 465     ALA I   131                                                      
REMARK 465     ASP I   431                                                      
REMARK 465     HIS I   432                                                      
REMARK 465     VAL I   433                                                      
REMARK 465     LEU I   434                                                      
REMARK 465     PRO I   435                                                      
REMARK 465     GLU I   436                                                      
REMARK 465     LEU I   437                                                      
REMARK 465     ASN I   438                                                      
REMARK 465     GLU I   458                                                      
REMARK 465     ALA I   459                                                      
REMARK 465     PRO I   460                                                      
REMARK 465     ASP I   461                                                      
REMARK 465     LEU I   462                                                      
REMARK 465     TYR I   463                                                      
REMARK 465     ASN I   464                                                      
REMARK 465     ARG I   465                                                      
REMARK 465     LYS I   466                                                      
REMARK 465     GLY I   467                                                      
REMARK 465     LYS I   468                                                      
REMARK 465     TYR I   469                                                      
REMARK 465     SER I   758                                                      
REMARK 465     ASP I   759                                                      
REMARK 465     GLU I   760                                                      
REMARK 465     GLU I   761                                                      
REMARK 465     GLU I   762                                                      
REMARK 465     GLU I   763                                                      
REMARK 465     ALA I   764                                                      
REMARK 465     SER I   765                                                      
REMARK 465     ASN I   766                                                      
REMARK 465     LYS I   767                                                      
REMARK 465     PRO I   768                                                      
REMARK 465     VAL I   769                                                      
REMARK 465     LYS I   770                                                      
REMARK 465     ILE I   771                                                      
REMARK 465     LYS I   772                                                      
REMARK 465     GLU I   773                                                      
REMARK 465     GLU I   774                                                      
REMARK 465     VAL I   775                                                      
REMARK 465     LEU I   776                                                      
REMARK 465     SER I   777                                                      
REMARK 465     GLU I   778                                                      
REMARK 465     SER I   779                                                      
REMARK 465     GLU I   780                                                      
REMARK 465     ALA I   781                                                      
REMARK 465     GLU I   782                                                      
REMARK 465     ASN I   783                                                      
REMARK 465     GLN I   784                                                      
REMARK 465     GLN I   785                                                      
REMARK 465     ALA I   786                                                      
REMARK 465     GLY I   787                                                      
REMARK 465     ALA I   788                                                      
REMARK 465     ALA I   789                                                      
REMARK 465     ALA I   790                                                      
REMARK 465     LEU I   791                                                      
REMARK 465     ALA I   792                                                      
REMARK 465     PRO I   793                                                      
REMARK 465     GLU I   794                                                      
REMARK 465     ILE I   795                                                      
REMARK 465     VAL I   796                                                      
REMARK 465     ILE I   797                                                      
REMARK 465     LYS I   798                                                      
REMARK 465     VAL I   799                                                      
REMARK 465     GLU I   800                                                      
REMARK 465     LYS I   801                                                      
REMARK 465     LEU I   802                                                      
REMARK 465     ASP I   803                                                      
REMARK 465     PRO I   804                                                      
REMARK 465     GLU I   805                                                      
REMARK 465     LEU I   806                                                      
REMARK 465     ASP I   807                                                      
REMARK 465     SER I   808                                                      
REMARK 465     MET J     1                                                      
REMARK 465     GLU J    96                                                      
REMARK 465     GLU J    97                                                      
REMARK 465     PRO J    98                                                      
REMARK 465     ILE J    99                                                      
REMARK 465     ASN J   100                                                      
REMARK 465     LYS J   101                                                      
REMARK 465     ARG J   102                                                      
REMARK 465     LEU J   103                                                      
REMARK 465     PHE J   104                                                      
REMARK 465     GLU J   105                                                      
REMARK 465     LYS J   106                                                      
REMARK 465     TYR J   107                                                      
REMARK 465     LEU J   108                                                      
REMARK 465     LYS J   109                                                      
REMARK 465     ASP J   110                                                      
REMARK 465     GLU J   111                                                      
REMARK 465     SER J   112                                                      
REMARK 465     GLY J   113                                                      
REMARK 465     PHE J   114                                                      
REMARK 465     LYS J   115                                                      
REMARK 465     ASP J   116                                                      
REMARK 465     PRO J   117                                                      
REMARK 465     SER J   118                                                      
REMARK 465     SER J   119                                                      
REMARK 465     ASP J   120                                                      
REMARK 465     TRP J   121                                                      
REMARK 465     GLU J   122                                                      
REMARK 465     MET J   123                                                      
REMARK 465     ILE J   534                                                      
REMARK 465     GLY J   535                                                      
REMARK 465     ALA J   536                                                      
REMARK 465     ASP J   537                                                      
REMARK 465     ILE J   538                                                      
REMARK 465     LYS J   539                                                      
REMARK 465     ASP J   540                                                      
REMARK 465     LYS J   541                                                      
REMARK 465     LEU J   542                                                      
REMARK 465     LYS J   543                                                      
REMARK 465     CYS J   544                                                      
REMARK 465     TYR J   545                                                      
REMARK 465     ASP J   546                                                      
REMARK 465     PHE J   547                                                      
REMARK 465     ASP J   548                                                      
REMARK 465     VAL J   549                                                      
REMARK 465     HIS J   550                                                      
REMARK 465     THR J   551                                                      
REMARK 465     MET J   552                                                      
REMARK 465     LYS J   553                                                      
REMARK 465     THR J   554                                                      
REMARK 465     LEU J   555                                                      
REMARK 465     LYS J   556                                                      
REMARK 465     ASN J   557                                                      
REMARK 465     ILE J   558                                                      
REMARK 465     ILE J   559                                                      
REMARK 465     SER J   560                                                      
REMARK 465     PRO J   561                                                      
REMARK 465     PRO J   562                                                      
REMARK 465     TRP J   563                                                      
REMARK 465     ASP J   564                                                      
REMARK 465     PHE J   565                                                      
REMARK 465     ARG J   566                                                      
REMARK 465     GLU J   567                                                      
REMARK 465     PHE J   568                                                      
REMARK 465     GLU J   569                                                      
REMARK 465     VAL J   570                                                      
REMARK 465     GLU J   571                                                      
REMARK 465     LYS J   572                                                      
REMARK 465     GLN J   573                                                      
REMARK 465     THR J   574                                                      
REMARK 465     ALA J   575                                                      
REMARK 465     GLU J   576                                                      
REMARK 465     GLU J   577                                                      
REMARK 465     THR J   578                                                      
REMARK 465     GLY J   579                                                      
REMARK 465     LEU J   580                                                      
REMARK 465     THR J   581                                                      
REMARK 465     PRO J   582                                                      
REMARK 465     LEU J   583                                                      
REMARK 465     GLU J   584                                                      
REMARK 465     THR J   585                                                      
REMARK 465     SER J   586                                                      
REMARK 465     ARG J   587                                                      
REMARK 465     LYS J   588                                                      
REMARK 465     THR J   589                                                      
REMARK 465     PRO J   590                                                      
REMARK 465     ASP J   591                                                      
REMARK 465     SER J   592                                                      
REMARK 465     ARG J   593                                                      
REMARK 465     PRO J   594                                                      
REMARK 465     SER J   595                                                      
REMARK 465     LEU J   596                                                      
REMARK 465     GLU J   597                                                      
REMARK 465     GLU J   598                                                      
REMARK 465     THR J   599                                                      
REMARK 465     PHE J   600                                                      
REMARK 465     GLU J   601                                                      
REMARK 465     ILE J   602                                                      
REMARK 465     GLU J   603                                                      
REMARK 465     MET J   604                                                      
REMARK 465     ASN J   605                                                      
REMARK 465     GLU J   606                                                      
REMARK 465     SER J   607                                                      
REMARK 465     ASP J   608                                                      
REMARK 465     MET J   609                                                      
REMARK 465     MET J   610                                                      
REMARK 465     LEU J   611                                                      
REMARK 465     GLU J   612                                                      
REMARK 465     THR J   613                                                      
REMARK 465     SER J   614                                                      
REMARK 465     MET J   615                                                      
REMARK 465     SER J   616                                                      
REMARK 465     ASP J   617                                                      
REMARK 465     HIS J   618                                                      
REMARK 465     SER J   619                                                      
REMARK 465     THR J   620                                                      
REMARK 465     MET K     1                                                      
REMARK 465     ASP K    94                                                      
REMARK 465     MET K    95                                                      
REMARK 465     GLU K    96                                                      
REMARK 465     GLU K    97                                                      
REMARK 465     PRO K    98                                                      
REMARK 465     ILE K    99                                                      
REMARK 465     ASN K   100                                                      
REMARK 465     LYS K   101                                                      
REMARK 465     ARG K   102                                                      
REMARK 465     LEU K   103                                                      
REMARK 465     PHE K   104                                                      
REMARK 465     GLU K   105                                                      
REMARK 465     LYS K   106                                                      
REMARK 465     TYR K   107                                                      
REMARK 465     LEU K   108                                                      
REMARK 465     LYS K   109                                                      
REMARK 465     ASP K   110                                                      
REMARK 465     GLU K   111                                                      
REMARK 465     SER K   112                                                      
REMARK 465     GLY K   113                                                      
REMARK 465     PHE K   114                                                      
REMARK 465     LYS K   115                                                      
REMARK 465     ASP K   116                                                      
REMARK 465     PRO K   117                                                      
REMARK 465     SER K   118                                                      
REMARK 465     SER K   119                                                      
REMARK 465     ASP K   120                                                      
REMARK 465     TRP K   121                                                      
REMARK 465     GLU K   122                                                      
REMARK 465     MET K   123                                                      
REMARK 465     SER K   124                                                      
REMARK 465     GLN K   125                                                      
REMARK 465     SER K   126                                                      
REMARK 465     GLY K   528                                                      
REMARK 465     ASP K   529                                                      
REMARK 465     SER K   530                                                      
REMARK 465     GLU K   531                                                      
REMARK 465     ALA K   532                                                      
REMARK 465     TYR K   533                                                      
REMARK 465     ILE K   534                                                      
REMARK 465     GLY K   535                                                      
REMARK 465     ALA K   536                                                      
REMARK 465     ASP K   537                                                      
REMARK 465     ILE K   538                                                      
REMARK 465     LYS K   539                                                      
REMARK 465     ASP K   540                                                      
REMARK 465     LYS K   541                                                      
REMARK 465     LEU K   542                                                      
REMARK 465     LYS K   543                                                      
REMARK 465     CYS K   544                                                      
REMARK 465     TYR K   545                                                      
REMARK 465     ASP K   546                                                      
REMARK 465     PHE K   547                                                      
REMARK 465     ASP K   548                                                      
REMARK 465     VAL K   549                                                      
REMARK 465     HIS K   550                                                      
REMARK 465     THR K   551                                                      
REMARK 465     MET K   552                                                      
REMARK 465     LYS K   553                                                      
REMARK 465     THR K   554                                                      
REMARK 465     LEU K   555                                                      
REMARK 465     LYS K   556                                                      
REMARK 465     ASN K   557                                                      
REMARK 465     ILE K   558                                                      
REMARK 465     ILE K   559                                                      
REMARK 465     SER K   560                                                      
REMARK 465     PRO K   561                                                      
REMARK 465     PRO K   562                                                      
REMARK 465     TRP K   563                                                      
REMARK 465     ASP K   564                                                      
REMARK 465     PHE K   565                                                      
REMARK 465     ARG K   566                                                      
REMARK 465     GLU K   567                                                      
REMARK 465     PHE K   568                                                      
REMARK 465     GLU K   569                                                      
REMARK 465     VAL K   570                                                      
REMARK 465     GLU K   571                                                      
REMARK 465     LYS K   572                                                      
REMARK 465     GLN K   573                                                      
REMARK 465     THR K   574                                                      
REMARK 465     ALA K   575                                                      
REMARK 465     GLU K   576                                                      
REMARK 465     GLU K   577                                                      
REMARK 465     THR K   578                                                      
REMARK 465     GLY K   579                                                      
REMARK 465     LEU K   580                                                      
REMARK 465     THR K   581                                                      
REMARK 465     PRO K   582                                                      
REMARK 465     LEU K   583                                                      
REMARK 465     GLU K   584                                                      
REMARK 465     THR K   585                                                      
REMARK 465     SER K   586                                                      
REMARK 465     ARG K   587                                                      
REMARK 465     LYS K   588                                                      
REMARK 465     THR K   589                                                      
REMARK 465     PRO K   590                                                      
REMARK 465     ASP K   591                                                      
REMARK 465     SER K   592                                                      
REMARK 465     ARG K   593                                                      
REMARK 465     PRO K   594                                                      
REMARK 465     SER K   595                                                      
REMARK 465     LEU K   596                                                      
REMARK 465     GLU K   597                                                      
REMARK 465     GLU K   598                                                      
REMARK 465     THR K   599                                                      
REMARK 465     PHE K   600                                                      
REMARK 465     GLU K   601                                                      
REMARK 465     ILE K   602                                                      
REMARK 465     GLU K   603                                                      
REMARK 465     MET K   604                                                      
REMARK 465     ASN K   605                                                      
REMARK 465     GLU K   606                                                      
REMARK 465     SER K   607                                                      
REMARK 465     ASP K   608                                                      
REMARK 465     MET K   609                                                      
REMARK 465     MET K   610                                                      
REMARK 465     LEU K   611                                                      
REMARK 465     GLU K   612                                                      
REMARK 465     THR K   613                                                      
REMARK 465     SER K   614                                                      
REMARK 465     MET K   615                                                      
REMARK 465     SER K   616                                                      
REMARK 465     ASP K   617                                                      
REMARK 465     HIS K   618                                                      
REMARK 465     SER K   619                                                      
REMARK 465     THR K   620                                                      
REMARK 465     THR L     2                                                      
REMARK 465     GLU M    40                                                      
REMARK 465     GLN M    41                                                      
REMARK 465     ASP M    42                                                      
REMARK 465     ASN M    43                                                      
REMARK 465     GLY M    44                                                      
REMARK 465     GLY M    45                                                      
REMARK 465     THR M    46                                                      
REMARK 465     THR M    47                                                      
REMARK 465     ASN M    68                                                      
REMARK 465     VAL M    69                                                      
REMARK 465     PRO M    70                                                      
REMARK 465     PRO M    71                                                      
REMARK 465     ILE M    72                                                      
REMARK 465     GLY M    73                                                      
REMARK 465     ASN M    74                                                      
REMARK 465     MET N     1                                                      
REMARK 465     ALA N     2                                                      
REMARK 465     ALA N     3                                                      
REMARK 465     ALA N     4                                                      
REMARK 465     VAL N     5                                                      
REMARK 465     VAL N     6                                                      
REMARK 465     VAL N     7                                                      
REMARK 465     ALA N     8                                                      
REMARK 465     GLU N     9                                                      
REMARK 465     GLY N    10                                                      
REMARK 465     ASP N    11                                                      
REMARK 465     SER N    12                                                      
REMARK 465     ASP N    13                                                      
REMARK 465     SER N    14                                                      
REMARK 465     GLY N    30                                                      
REMARK 465     LEU N    31                                                      
REMARK 465     VAL N    32                                                      
REMARK 465     PRO N    33                                                      
REMARK 465     PRO N    34                                                      
REMARK 465     ALA N    35                                                      
REMARK 465     ALA N    36                                                      
REMARK 465     LEU N    37                                                      
REMARK 465     GLY N    38                                                      
REMARK 465     LEU N    39                                                      
REMARK 465     VAL N    40                                                      
REMARK 465     SER N    41                                                      
REMARK 465     SER N    42                                                      
REMARK 465     ARG N    43                                                      
REMARK 465     THR N    44                                                      
REMARK 465     SER N    45                                                      
REMARK 465     GLY N    46                                                      
REMARK 465     ALA N    47                                                      
REMARK 465     VAL N    48                                                      
REMARK 465     PRO N    49                                                      
REMARK 465     PRO N    50                                                      
REMARK 465     LYS N    51                                                      
REMARK 465     GLU N    52                                                      
REMARK 465     GLY N    66                                                      
REMARK 465     LEU N    67                                                      
REMARK 465     HIS N    68                                                      
REMARK 465     SER N    69                                                      
REMARK 465     ASP N   103                                                      
REMARK 465     GLU N   104                                                      
REMARK 465     PRO N   105                                                      
REMARK 465     GLN N   106                                                      
REMARK 465     GLU N   192                                                      
REMARK 465     GLY N   193                                                      
REMARK 465     GLY N   194                                                      
REMARK 465     THR N   195                                                      
REMARK 465     CYS N   221                                                      
REMARK 465     ALA N   222                                                      
REMARK 465     GLY N   223                                                      
REMARK 465     CYS N   224                                                      
REMARK 465     SER N   225                                                      
REMARK 465     SER N   226                                                      
REMARK 465     ASP N   227                                                      
REMARK 465     LYS N   228                                                      
REMARK 465     GLN N   229                                                      
REMARK 465     GLN N   230                                                      
REMARK 465     CYS N   231                                                      
REMARK 465     LEU N   305                                                      
REMARK 465     GLN N   306                                                      
REMARK 465     ASP N   307                                                      
REMARK 465     GLY N   308                                                      
REMARK 465     PRO N   309                                                      
REMARK 465     ALA N   310                                                      
REMARK 465     ARG N   311                                                      
REMARK 465     PRO N   312                                                      
REMARK 465     ALA N   313                                                      
REMARK 465     SER N   314                                                      
REMARK 465     PRO N   315                                                      
REMARK 465     GLU N   316                                                      
REMARK 465     ALA N   317                                                      
REMARK 465     GLY N   318                                                      
REMARK 465     ASN N   319                                                      
REMARK 465     GLY N   444                                                      
REMARK 465     ASP N   445                                                      
REMARK 465     SER N   446                                                      
REMARK 465     ASP N   447                                                      
REMARK 465     GLY N   448                                                      
REMARK 465     THR N   449                                                      
REMARK 465     GLY N   450                                                      
REMARK 465     THR N   459                                                      
REMARK 465     ASP N   460                                                      
REMARK 465     PRO N   461                                                      
REMARK 465     ALA N   462                                                      
REMARK 465     SER N   463                                                      
REMARK 465     LEU N   464                                                      
REMARK 465     GLU N   465                                                      
REMARK 465     THR N   466                                                      
REMARK 465     GLY N   467                                                      
REMARK 465     GLN N   468                                                      
REMARK 465     ASP N   469                                                      
REMARK 465     SER N   470                                                      
REMARK 465     GLU N   471                                                      
REMARK 465     ASP N   472                                                      
REMARK 465     ASP N   473                                                      
REMARK 465     SER N   474                                                      
REMARK 465     GLY N   475                                                      
REMARK 465     ASP N   731                                                      
REMARK 465     SER N   732                                                      
REMARK 465     ASP N   733                                                      
REMARK 465     ASP N   734                                                      
REMARK 465     GLU N   735                                                      
REMARK 465     SER N   736                                                      
REMARK 465     ASP N   737                                                      
REMARK 465     SER N   738                                                      
REMARK 465     GLY N   739                                                      
REMARK 465     MET N   740                                                      
REMARK 465     ALA N   741                                                      
REMARK 465     SER N   742                                                      
REMARK 465     GLN N   743                                                      
REMARK 465     ALA N   744                                                      
REMARK 465     ASP N   745                                                      
REMARK 465     GLN N   746                                                      
REMARK 465     LYS N   747                                                      
REMARK 465     GLU N   748                                                      
REMARK 465     GLU N   749                                                      
REMARK 465     GLU N   750                                                      
REMARK 465     LEU N   751                                                      
REMARK 465     LEU N   752                                                      
REMARK 465     LEU N   753                                                      
REMARK 465     PHE N   754                                                      
REMARK 465     TRP N   755                                                      
REMARK 465     THR N   756                                                      
REMARK 465     TYR N   757                                                      
REMARK 465     ILE N   758                                                      
REMARK 465     GLN N   759                                                      
REMARK 465     ALA N   760                                                      
REMARK 465     MET N   761                                                      
REMARK 465     LEU N   762                                                      
REMARK 465     THR N   763                                                      
REMARK 465     ASN N   764                                                      
REMARK 465     LEU N   765                                                      
REMARK 465     GLU N   766                                                      
REMARK 465     SER N   767                                                      
REMARK 465     LEU N   768                                                      
REMARK 465     SER N   769                                                      
REMARK 465     LEU N   770                                                      
REMARK 465     ASP N   771                                                      
REMARK 465     ARG N   772                                                      
REMARK 465     ILE N   773                                                      
REMARK 465     TYR N   774                                                      
REMARK 465     ASN N   775                                                      
REMARK 465     MET N   776                                                      
REMARK 465     LEU N   777                                                      
REMARK 465     ARG N   778                                                      
REMARK 465     MET N   779                                                      
REMARK 465     PHE N   780                                                      
REMARK 465     VAL N   781                                                      
REMARK 465     VAL N   782                                                      
REMARK 465     THR N   783                                                      
REMARK 465     GLY N   784                                                      
REMARK 465     PRO N   785                                                      
REMARK 465     ALA N   786                                                      
REMARK 465     LEU N   787                                                      
REMARK 465     ALA N   788                                                      
REMARK 465     GLU N   789                                                      
REMARK 465     ILE N   790                                                      
REMARK 465     ASP N   791                                                      
REMARK 465     LEU N   792                                                      
REMARK 465     GLN N   793                                                      
REMARK 465     GLU N   794                                                      
REMARK 465     LEU N   795                                                      
REMARK 465     GLN N   796                                                      
REMARK 465     GLY N   797                                                      
REMARK 465     TYR N   798                                                      
REMARK 465     LEU N   799                                                      
REMARK 465     GLN N   800                                                      
REMARK 465     LYS N   801                                                      
REMARK 465     LYS N   802                                                      
REMARK 465     VAL N   803                                                      
REMARK 465     ARG N   804                                                      
REMARK 465     ASP N   805                                                      
REMARK 465     GLN N   806                                                      
REMARK 465     GLN N   807                                                      
REMARK 465     LEU N   808                                                      
REMARK 465     VAL N   809                                                      
REMARK 465     TYR N   810                                                      
REMARK 465     SER N   811                                                      
REMARK 465     ALA N   812                                                      
REMARK 465     GLY N   813                                                      
REMARK 465     VAL N   814                                                      
REMARK 465     TYR N   815                                                      
REMARK 465     ARG N   816                                                      
REMARK 465     LEU N   817                                                      
REMARK 465     PRO N   818                                                      
REMARK 465     LYS N   819                                                      
REMARK 465     ASN N   820                                                      
REMARK 465     CYS N   821                                                      
REMARK 465     SER N   822                                                      
REMARK 465     MET O     1                                                      
REMARK 465     ALA O     2                                                      
REMARK 465     SER O     3                                                      
REMARK 465     VAL O     4                                                      
REMARK 465     HIS O     5                                                      
REMARK 465     GLU O     6                                                      
REMARK 465     SER O     7                                                      
REMARK 465     LEU O     8                                                      
REMARK 465     TYR O     9                                                      
REMARK 465     PHE O    10                                                      
REMARK 465     ASN O    11                                                      
REMARK 465     PRO O    12                                                      
REMARK 465     MET O    13                                                      
REMARK 465     MET O    14                                                      
REMARK 465     THR O    15                                                      
REMARK 465     ASN O    16                                                      
REMARK 465     GLY O    17                                                      
REMARK 465     VAL O    18                                                      
REMARK 465     VAL O    19                                                      
REMARK 465     HIS O    20                                                      
REMARK 465     ALA O    21                                                      
REMARK 465     ASN O    22                                                      
REMARK 465     VAL O    23                                                      
REMARK 465     PHE O    24                                                      
REMARK 465     GLY O    25                                                      
REMARK 465     ILE O    26                                                      
REMARK 465     THR O   169A                                                     
REMARK 465     VAL O   170                                                      
REMARK 465     GLU O   171                                                      
REMARK 465     ASP O   172                                                      
REMARK 465     ALA O   173                                                      
REMARK 465     ASP O   174                                                      
REMARK 465     MET O   175                                                      
REMARK 465     GLU O   176                                                      
REMARK 465     LEU O   177                                                      
REMARK 465     THR O   178                                                      
REMARK 465     SER O   179                                                      
REMARK 465     ARG O   180                                                      
REMARK 465     ASP O   181                                                      
REMARK 465     GLU O   182                                                      
REMARK 465     GLY O   183                                                      
REMARK 465     GLU O   184                                                      
REMARK 465     ARG O   185                                                      
REMARK 465     LYS O   186                                                      
REMARK 465     MET O   187                                                      
REMARK 465     GLU O   188                                                      
REMARK 465     LYS O   189                                                      
REMARK 465     GLU O   190                                                      
REMARK 465     GLU O   191                                                      
REMARK 465     LEU O   192                                                      
REMARK 465     ASP O   193                                                      
REMARK 465     VAL O   194                                                      
REMARK 465     SER O   195                                                      
REMARK 465     VAL O   196                                                      
REMARK 465     ARG O   197                                                      
REMARK 465     GLU O   198                                                      
REMARK 465     GLU O   199                                                      
REMARK 465     GLU O   200                                                      
REMARK 465     VAL O   201                                                      
REMARK 465     SER O   202                                                      
REMARK 465     CYS O   203                                                      
REMARK 465     SER O   204                                                      
REMARK 465     GLY O   205                                                      
REMARK 465     ALA O   453                                                      
REMARK 465     VAL O   454                                                      
REMARK 465     ASN O   455                                                      
REMARK 465     ALA O   456                                                      
REMARK 465     GLY O   457                                                      
REMARK 465     VAL O   458                                                      
REMARK 465     HIS O   747                                                      
REMARK 465     GLY O   748                                                      
REMARK 465     MET P     7                                                      
REMARK 465     VAL P     8                                                      
REMARK 465     PRO P     9                                                      
REMARK 465     VAL P    10                                                      
REMARK 465     ALA P    11                                                      
REMARK 465     VAL P    12                                                      
REMARK 465     THR P    13                                                      
REMARK 465     ALA P    14                                                      
REMARK 465     ALA P    15                                                      
REMARK 465     VAL P    16                                                      
REMARK 465     ALA P    17                                                      
REMARK 465     PRO P    18                                                      
REMARK 465     VAL P    19                                                      
REMARK 465     LEU P    20                                                      
REMARK 465     SER P    21                                                      
REMARK 465     ILE P    22                                                      
REMARK 465     ASN P    23                                                      
REMARK 465     SER P    24                                                      
REMARK 465     ASP P    25                                                      
REMARK 465     VAL P   135                                                      
REMARK 465     ASP P   136                                                      
REMARK 465     SER P   137                                                      
REMARK 465     LEU P   138                                                      
REMARK 465     GLY P   139                                                      
REMARK 465     PRO P   140                                                      
REMARK 465     LEU P   141                                                      
REMARK 465     GLU P   142                                                      
REMARK 465     LYS P   143                                                      
REMARK 465     GLY P   144                                                      
REMARK 465     GLN P   145                                                      
REMARK 465     VAL P   146                                                      
REMARK 465     GLY P   501                                                      
REMARK 465     GLU P   502                                                      
REMARK 465     ILE P   503                                                      
REMARK 465     VAL P   504                                                      
REMARK 465     GLU P   505                                                      
REMARK 465     HIS P   506                                                      
REMARK 465     LEU P   507                                                      
REMARK 465     GLU P   508                                                      
REMARK 465     GLU P   509                                                      
REMARK 465     SER P   510                                                      
REMARK 465     PHE P   539                                                      
REMARK 465     ASN P   540                                                      
REMARK 465     ASP P   541                                                      
REMARK 465     THR P   542                                                      
REMARK 465     ARG P   543                                                      
REMARK 465     GLU P   544                                                      
REMARK 465     GLU P   545                                                      
REMARK 465     GLY P   546                                                      
REMARK 465     LYS P   547                                                      
REMARK 465     ALA P   548                                                      
REMARK 465     LEU P   549                                                      
REMARK 465     LEU P   550                                                      
REMARK 465     ARG P   551                                                      
REMARK 465     GLN P   552                                                      
REMARK 465     ILE P   553                                                      
REMARK 465     LEU P   554                                                      
REMARK 465     GLN P   555                                                      
REMARK 465     LEU P   556                                                      
REMARK 465     ARG P   557                                                      
REMARK 465     ASN P   558                                                      
REMARK 465     GLN P   559                                                      
REMARK 465     GLY P   560                                                      
REMARK 465     GLU P   561                                                      
REMARK 465     THR P   562                                                      
REMARK 465     PRO P   563                                                      
REMARK 465     THR P   564                                                      
REMARK 465     THR P   565                                                      
REMARK 465     GLU P   566                                                      
REMARK 465     VAL P   567                                                      
REMARK 465     PRO P   568                                                      
REMARK 465     ALA P   569                                                      
REMARK 465     PRO P   570                                                      
REMARK 465     PHE P   571                                                      
REMARK 465     PHE P   572                                                      
REMARK 465     LEU P   573                                                      
REMARK 465     PRO P   574                                                      
REMARK 465     ALA P   575                                                      
REMARK 465     SER P   576                                                      
REMARK 465     LEU P   577                                                      
REMARK 465     SER P   578                                                      
REMARK 465     ALA P   579                                                      
REMARK 465     ASN P   580                                                      
REMARK 465     ASN P   581                                                      
REMARK 465     THR P   582                                                      
REMARK 465     PRO P   583                                                      
REMARK 465     THR P   584                                                      
REMARK 465     ARG P   585                                                      
REMARK 465     ARG P   586                                                      
REMARK 465     VAL P   587                                                      
REMARK 465     SER P   588                                                      
REMARK 465     PRO P   589                                                      
REMARK 465     LEU P   590                                                      
REMARK 465     ASN P   591                                                      
REMARK 465     LEU P   592                                                      
REMARK 465     SER P   593                                                      
REMARK 465     SER P   594                                                      
REMARK 465     VAL P   595                                                      
REMARK 465     THR P   596                                                      
REMARK 465     PRO P   597                                                      
REMARK 465     MET R     1                                                      
REMARK 465     ASP R     2                                                      
REMARK 465     GLN R     3                                                      
REMARK 465     ASP R     4                                                      
REMARK 465     TYR R     5                                                      
REMARK 465     GLU R     6                                                      
REMARK 465     ARG R     7                                                      
REMARK 465     ARG R     8                                                      
REMARK 465     LEU R     9                                                      
REMARK 465     LEU R    10                                                      
REMARK 465     ARG R    11                                                      
REMARK 465     GLN R    12                                                      
REMARK 465     ILE R    13                                                      
REMARK 465     VAL R    14                                                      
REMARK 465     ILE R    15                                                      
REMARK 465     GLN R    16                                                      
REMARK 465     ASN R    17                                                      
REMARK 465     GLU R    18                                                      
REMARK 465     ASN R    19                                                      
REMARK 465     THR R    20                                                      
REMARK 465     MET R    21                                                      
REMARK 465     PRO R    22                                                      
REMARK 465     ARG R    23                                                      
REMARK 465     VAL R    24                                                      
REMARK 465     THR R    25                                                      
REMARK 465     GLU R    26                                                      
REMARK 465     MET R    27                                                      
REMARK 465     ARG R    28                                                      
REMARK 465     ARG R    29                                                      
REMARK 465     THR R    30                                                      
REMARK 465     LEU R    31                                                      
REMARK 465     THR R    32                                                      
REMARK 465     PRO R    33                                                      
REMARK 465     ALA R    34                                                      
REMARK 465     SER R    35                                                      
REMARK 465     SER R    36                                                      
REMARK 465     PRO R    37                                                      
REMARK 465     VAL R    38                                                      
REMARK 465     SER R    39                                                      
REMARK 465     SER R    40                                                      
REMARK 465     PRO R    41                                                      
REMARK 465     GLU R    68                                                      
REMARK 465     LYS R    69                                                      
REMARK 465     SER R    70                                                      
REMARK 465     PRO R    71                                                      
REMARK 465     SER R    72                                                      
REMARK 465     GLN R    73                                                      
REMARK 465     ASN R    74                                                      
REMARK 465     ARG R    75                                                      
REMARK 465     LYS R    76                                                      
REMARK 465     ALA R    77                                                      
REMARK 465     LYS R    78                                                      
REMARK 465     ASP R    79                                                      
REMARK 465     ALA R    80                                                      
REMARK 465     THR R    81                                                      
REMARK 465     SER R    82                                                      
REMARK 465     ASP R    83                                                      
REMARK 465     ASN R    84                                                      
REMARK 465     GLY R    85                                                      
REMARK 465     LYS R    86                                                      
REMARK 465     ASP R    87                                                      
REMARK 465     ASP R   109                                                      
REMARK 465     PRO R   110                                                      
REMARK 465     GLN R   111                                                      
REMARK 465     THR R   112                                                      
REMARK 465     GLU R   113                                                      
REMARK 465     ASP R   114                                                      
REMARK 465     ARG R   115                                                      
REMARK 465     ARG R   116                                                      
REMARK 465     LEU R   117                                                      
REMARK 465     GLN R   118                                                      
REMARK 465     PRO R   119                                                      
REMARK 465     SER R   120                                                      
REMARK 465     THR R   121                                                      
REMARK 465     PRO R   122                                                      
REMARK 465     GLU R   123                                                      
REMARK 465     LYS R   124                                                      
REMARK 465     SER R   133                                                      
REMARK 465     THR R   134                                                      
REMARK 465     LYS R   135                                                      
REMARK 465     ARG R   136                                                      
REMARK 465     SER R   137                                                      
REMARK 465     SER R   138                                                      
REMARK 465     PRO R   139                                                      
REMARK 465     ASP R   140                                                      
REMARK 465     ASP R   141                                                      
REMARK 465     GLY R   142                                                      
REMARK 465     ASN R   143                                                      
REMARK 465     ASP R   144                                                      
REMARK 465     VAL R   145                                                      
REMARK 465     PRO R   164                                                      
REMARK 465     ARG R   165                                                      
REMARK 465     LYS R   166                                                      
REMARK 465     PRO R   167                                                      
REMARK 465     THR R   168                                                      
REMARK 465     ARG R   169                                                      
REMARK 465     LYS R   170                                                      
REMARK 465     ILE R   171                                                      
REMARK 465     LYS R   475                                                      
REMARK 465     THR R   476                                                      
REMARK 465     ARG R   477                                                      
REMARK 465     SER R   478                                                      
REMARK 465     THR R   479                                                      
REMARK 465     LYS R   480                                                      
REMARK 465     GLU R   481                                                      
REMARK 465     SER R   482                                                      
REMARK 465     MET S     1                                                      
REMARK 465     SER S     2                                                      
REMARK 465     ARG S     3                                                      
REMARK 465     ARG S     4                                                      
REMARK 465     PRO S     5                                                      
REMARK 465     CYS S     6                                                      
REMARK 465     SER S     7                                                      
REMARK 465     CYS S     8                                                      
REMARK 465     ALA S     9                                                      
REMARK 465     LEU S    10                                                      
REMARK 465     ARG S    11                                                      
REMARK 465     PRO S    12                                                      
REMARK 465     PRO S    13                                                      
REMARK 465     ARG S    14                                                      
REMARK 465     CYS S    15                                                      
REMARK 465     SER S    16                                                      
REMARK 465     CYS S    17                                                      
REMARK 465     SER S    18                                                      
REMARK 465     ALA S    19                                                      
REMARK 465     SER S    20                                                      
REMARK 465     PRO S    21                                                      
REMARK 465     SER S    22                                                      
REMARK 465     ALA S    23                                                      
REMARK 465     VAL S    24                                                      
REMARK 465     THR S    25                                                      
REMARK 465     ALA S    26                                                      
REMARK 465     ALA S    27                                                      
REMARK 465     GLY S    28                                                      
REMARK 465     ARG S    29                                                      
REMARK 465     PRO S    30                                                      
REMARK 465     ARG S    31                                                      
REMARK 465     PRO S    32                                                      
REMARK 465     SER S    33                                                      
REMARK 465     ASP S    34                                                      
REMARK 465     SER S    35                                                      
REMARK 465     CYS S    36                                                      
REMARK 465     LYS S    37                                                      
REMARK 465     GLU S    38                                                      
REMARK 465     GLU S    39                                                      
REMARK 465     SER S    40                                                      
REMARK 465     SER S    41                                                      
REMARK 465     THR S    42                                                      
REMARK 465     LEU S    43                                                      
REMARK 465     SER S    44                                                      
REMARK 465     VAL S    45                                                      
REMARK 465     LYS S    46                                                      
REMARK 465     MET S    47                                                      
REMARK 465     LYS S    48                                                      
REMARK 465     CYS S    49                                                      
REMARK 465     ASP S    50                                                      
REMARK 465     PHE S    51                                                      
REMARK 465     ASN S    52                                                      
REMARK 465     CYS S    53                                                      
REMARK 465     ASN S    54                                                      
REMARK 465     HIS S    55                                                      
REMARK 465     VAL S    56                                                      
REMARK 465     HIS S    57                                                      
REMARK 465     SER S    58                                                      
REMARK 465     GLY S    59                                                      
REMARK 465     LEU S    60                                                      
REMARK 465     LYS S    61                                                      
REMARK 465     LEU S    62                                                      
REMARK 465     VAL S    63                                                      
REMARK 465     LYS S    64                                                      
REMARK 465     PRO S    65                                                      
REMARK 465     ASP S    66                                                      
REMARK 465     ASP S    67                                                      
REMARK 465     ILE S    68                                                      
REMARK 465     GLY S    69                                                      
REMARK 465     ARG S    70                                                      
REMARK 465     LEU S    71                                                      
REMARK 465     VAL S    72                                                      
REMARK 465     SER S    73                                                      
REMARK 465     TYR S    74                                                      
REMARK 465     THR S    75                                                      
REMARK 465     PRO S    76                                                      
REMARK 465     ALA S    77                                                      
REMARK 465     TYR S    78                                                      
REMARK 465     LEU S    79                                                      
REMARK 465     GLU S    80                                                      
REMARK 465     GLY S    81                                                      
REMARK 465     SER S    82                                                      
REMARK 465     CYS S    83                                                      
REMARK 465     LYS S    84                                                      
REMARK 465     ASP S    85                                                      
REMARK 465     CYS S    86                                                      
REMARK 465     ILE S    87                                                      
REMARK 465     LYS S    88                                                      
REMARK 465     ASP S    89                                                      
REMARK 465     TYR S    90                                                      
REMARK 465     GLU S    91                                                      
REMARK 465     ARG S    92                                                      
REMARK 465     LEU S    93                                                      
REMARK 465     SER S    94                                                      
REMARK 465     CYS S    95                                                      
REMARK 465     ILE S    96                                                      
REMARK 465     GLY S    97                                                      
REMARK 465     SER S    98                                                      
REMARK 465     PRO S    99                                                      
REMARK 465     ILE S   100                                                      
REMARK 465     VAL S   101                                                      
REMARK 465     SER S   102                                                      
REMARK 465     PRO S   103                                                      
REMARK 465     ARG S   104                                                      
REMARK 465     ILE S   105                                                      
REMARK 465     VAL S   106                                                      
REMARK 465     GLN S   107                                                      
REMARK 465     LEU S   108                                                      
REMARK 465     GLU S   109                                                      
REMARK 465     THR S   110                                                      
REMARK 465     GLU S   111                                                      
REMARK 465     SER S   112                                                      
REMARK 465     LYS S   113                                                      
REMARK 465     ARG S   114                                                      
REMARK 465     LEU S   115                                                      
REMARK 465     HIS S   116                                                      
REMARK 465     ASN S   117                                                      
REMARK 465     LYS S   118                                                      
REMARK 465     GLU S   119                                                      
REMARK 465     ASN S   120                                                      
REMARK 465     GLN S   121                                                      
REMARK 465     HIS S   122                                                      
REMARK 465     VAL S   123                                                      
REMARK 465     GLN S   124                                                      
REMARK 465     GLN S   125                                                      
REMARK 465     THR S   126                                                      
REMARK 465     LEU S   127                                                      
REMARK 465     ASN S   128                                                      
REMARK 465     SER S   129                                                      
REMARK 465     THR S   130                                                      
REMARK 465     ASN S   131                                                      
REMARK 465     GLU S   132                                                      
REMARK 465     ILE S   133                                                      
REMARK 465     GLU S   134                                                      
REMARK 465     ALA S   135                                                      
REMARK 465     LEU S   136                                                      
REMARK 465     GLU S   137                                                      
REMARK 465     THR S   138                                                      
REMARK 465     SER S   139                                                      
REMARK 465     ARG S   140                                                      
REMARK 465     LEU S   141                                                      
REMARK 465     TYR S   142                                                      
REMARK 465     GLU S   143                                                      
REMARK 465     ASP S   144                                                      
REMARK 465     SER S   145                                                      
REMARK 465     GLY S   146                                                      
REMARK 465     TYR S   147                                                      
REMARK 465     SER S   148                                                      
REMARK 465     SER S   149                                                      
REMARK 465     PHE S   150                                                      
REMARK 465     SER S   151                                                      
REMARK 465     LEU S   152                                                      
REMARK 465     GLN S   153                                                      
REMARK 465     SER S   154                                                      
REMARK 465     GLY S   155                                                      
REMARK 465     LEU S   156                                                      
REMARK 465     SER S   157                                                      
REMARK 465     GLU S   158                                                      
REMARK 465     HIS S   159                                                      
REMARK 465     GLU S   160                                                      
REMARK 465     GLU S   161                                                      
REMARK 465     GLY S   162                                                      
REMARK 465     SER S   163                                                      
REMARK 465     LEU S   164                                                      
REMARK 465     LEU S   165                                                      
REMARK 465     GLU S   166                                                      
REMARK 465     GLU S   167                                                      
REMARK 465     ASN S   168                                                      
REMARK 465     PHE S   169                                                      
REMARK 465     GLY S   170                                                      
REMARK 465     ASP S   171                                                      
REMARK 465     SER S   172                                                      
REMARK 465     LEU S   173                                                      
REMARK 465     GLN S   174                                                      
REMARK 465     SER S   175                                                      
REMARK 465     CYS S   176                                                      
REMARK 465     LEU S   177                                                      
REMARK 465     LEU S   178                                                      
REMARK 465     GLN S   179                                                      
REMARK 465     ILE S   180                                                      
REMARK 465     GLN S   181                                                      
REMARK 465     SER S   182                                                      
REMARK 465     PRO S   183                                                      
REMARK 465     ASP S   184                                                      
REMARK 465     GLN S   185                                                      
REMARK 465     TYR S   186                                                      
REMARK 465     PRO S   187                                                      
REMARK 465     ASN S   188                                                      
REMARK 465     LYS S   189                                                      
REMARK 465     ASN S   190                                                      
REMARK 465     LEU S   191                                                      
REMARK 465     LEU S   192                                                      
REMARK 465     PRO S   193                                                      
REMARK 465     VAL S   194                                                      
REMARK 465     LEU S   195                                                      
REMARK 465     HIS S   196                                                      
REMARK 465     PHE S   197                                                      
REMARK 465     GLU S   198                                                      
REMARK 465     LYS S   199                                                      
REMARK 465     VAL S   200                                                      
REMARK 465     VAL S   201                                                      
REMARK 465     CYS S   202                                                      
REMARK 465     SER S   203                                                      
REMARK 465     THR S   204                                                      
REMARK 465     LEU S   205                                                      
REMARK 465     LYS S   206                                                      
REMARK 465     LYS S   207                                                      
REMARK 465     ASN S   208                                                      
REMARK 465     ALA S   209                                                      
REMARK 465     LYS S   210                                                      
REMARK 465     ARG S   211                                                      
REMARK 465     ASN S   212                                                      
REMARK 465     PRO S   213                                                      
REMARK 465     LYS S   214                                                      
REMARK 465     VAL S   215                                                      
REMARK 465     ASP S   216                                                      
REMARK 465     ARG S   217                                                      
REMARK 465     GLU S   218                                                      
REMARK 465     MET S   219                                                      
REMARK 465     LEU S   220                                                      
REMARK 465     LYS S   221                                                      
REMARK 465     GLU S   222                                                      
REMARK 465     ILE S   223                                                      
REMARK 465     ILE S   224                                                      
REMARK 465     ALA S   225                                                      
REMARK 465     ARG S   226                                                      
REMARK 465     GLY S   227                                                      
REMARK 465     ASN S   228                                                      
REMARK 465     PHE S   229                                                      
REMARK 465     ARG S   230                                                      
REMARK 465     LEU S   231                                                      
REMARK 465     GLN S   232                                                      
REMARK 465     ASN S   233                                                      
REMARK 465     ILE S   234                                                      
REMARK 465     ILE S   235                                                      
REMARK 465     GLY S   236                                                      
REMARK 465     ARG S   237                                                      
REMARK 465     LYS S   238                                                      
REMARK 465     MET S   239                                                      
REMARK 465     GLY S   240                                                      
REMARK 465     LEU S   241                                                      
REMARK 465     GLU S   242                                                      
REMARK 465     CYS S   243                                                      
REMARK 465     VAL S   244                                                      
REMARK 465     ASP S   245                                                      
REMARK 465     ILE S   246                                                      
REMARK 465     LEU S   247                                                      
REMARK 465     SER S   248                                                      
REMARK 465     GLU S   249                                                      
REMARK 465     LEU S   250                                                      
REMARK 465     PHE S   251                                                      
REMARK 465     ARG S   252                                                      
REMARK 465     ARG S   253                                                      
REMARK 465     GLY S   254                                                      
REMARK 465     LEU S   255                                                      
REMARK 465     ARG S   256                                                      
REMARK 465     HIS S   257                                                      
REMARK 465     VAL S   258                                                      
REMARK 465     LEU S   259                                                      
REMARK 465     ALA S   260                                                      
REMARK 465     THR S   261                                                      
REMARK 465     ILE S   262                                                      
REMARK 465     LEU S   263                                                      
REMARK 465     ALA S   264                                                      
REMARK 465     GLN S   265                                                      
REMARK 465     LEU S   266                                                      
REMARK 465     SER S   267                                                      
REMARK 465     ASP S   268                                                      
REMARK 465     MET S   269                                                      
REMARK 465     ASP S   270                                                      
REMARK 465     LEU S   271                                                      
REMARK 465     ILE S   272                                                      
REMARK 465     ASN S   273                                                      
REMARK 465     VAL S   274                                                      
REMARK 465     SER S   275                                                      
REMARK 465     LYS S   276                                                      
REMARK 465     VAL S   277                                                      
REMARK 465     SER S   278                                                      
REMARK 465     THR S   279                                                      
REMARK 465     THR S   280                                                      
REMARK 465     TRP S   281                                                      
REMARK 465     LYS S   282                                                      
REMARK 465     LYS S   283                                                      
REMARK 465     ILE S   284                                                      
REMARK 465     LEU S   285                                                      
REMARK 465     GLU S   286                                                      
REMARK 465     ASP S   287                                                      
REMARK 465     ASP S   288                                                      
REMARK 465     LYS S   289                                                      
REMARK 465     GLY S   290                                                      
REMARK 465     ALA S   291                                                      
REMARK 465     PHE S   292                                                      
REMARK 465     GLN S   293                                                      
REMARK 465     LEU S   294                                                      
REMARK 465     TYR S   295                                                      
REMARK 465     SER S   296                                                      
REMARK 465     LYS S   297                                                      
REMARK 465     ALA S   298                                                      
REMARK 465     ILE S   299                                                      
REMARK 465     GLN S   300                                                      
REMARK 465     ARG S   301                                                      
REMARK 465     VAL S   302                                                      
REMARK 465     THR S   303                                                      
REMARK 465     GLU S   304                                                      
REMARK 465     ASN S   305                                                      
REMARK 465     ASN S   306                                                      
REMARK 465     ASN S   307                                                      
REMARK 465     LYS S   308                                                      
REMARK 465     PHE S   309                                                      
REMARK 465     SER S   310                                                      
REMARK 465     PRO S   311                                                      
REMARK 465     HIS S   312                                                      
REMARK 465     ALA S   313                                                      
REMARK 465     SER S   314                                                      
REMARK 465     THR S   315                                                      
REMARK 465     ARG S   316                                                      
REMARK 465     GLU S   317                                                      
REMARK 465     TYR S   318                                                      
REMARK 465     ALA S   332                                                      
REMARK 465     ALA S   333                                                      
REMARK 465     GLN S   334                                                      
REMARK 465     THR S   335                                                      
REMARK 465     SER S   336                                                      
REMARK 465     LEU S   337                                                      
REMARK 465     LYS S   338                                                      
REMARK 465     LYS S   339                                                      
REMARK 465     ASP S   340                                                      
REMARK 465     ALA S   341                                                      
REMARK 465     GLN S   342                                                      
REMARK 465     THR S   343                                                      
REMARK 465     LYS S   344                                                      
REMARK 465     LEU S   345                                                      
REMARK 465     SER S   346                                                      
REMARK 465     ASN S   347                                                      
REMARK 465     GLN S   348                                                      
REMARK 465     GLY S   349                                                      
REMARK 465     ASP S   350                                                      
REMARK 465     GLN S   351                                                      
REMARK 465     LYS S   352                                                      
REMARK 465     GLY S   353                                                      
REMARK 465     SER S   354                                                      
REMARK 465     THR S   355                                                      
REMARK 465     THR S   437                                                      
REMARK 465     LYS S   438                                                      
REMARK 465     LYS S   439                                                      
REMARK 465     SER S   440                                                      
REMARK 465     LYS S   441                                                      
REMARK 465     LYS S   442                                                      
REMARK 465     ASN S   443                                                      
REMARK 465     LEU S   444                                                      
REMARK 465     ARG S   445                                                      
REMARK 465     ARG S   446                                                      
REMARK 465     LEU S   447                                                      
REMARK 465     LEU W    26                                                      
REMARK 465     GLU W    27                                                      
REMARK 465     THR W    28                                                      
REMARK 465     ARG W    29                                                      
REMARK 465     LYS W    30                                                      
REMARK 465     LYS W    31                                                      
REMARK 465     GLN W    32                                                      
REMARK 465     LYS W    33                                                      
REMARK 465     GLU W    34                                                      
REMARK 465     ASP W    35                                                      
REMARK 465     VAL W    36                                                      
REMARK 465     GLU W    37                                                      
REMARK 465     VAL W    38                                                      
REMARK 465     VAL W    39                                                      
REMARK 465     GLY W    40                                                      
REMARK 465     GLY W    41                                                      
REMARK 465     SER W    42                                                      
REMARK 465     ASP W    43                                                      
REMARK 465     GLY W    44                                                      
REMARK 465     GLU W    45                                                      
REMARK 465     GLY W    46                                                      
REMARK 465     ALA W    47                                                      
REMARK 465     ILE W    48                                                      
REMARK 465     GLY W    49                                                      
REMARK 465     LEU W    50                                                      
REMARK 465     SER W    51                                                      
REMARK 465     SER W    52                                                      
REMARK 465     ASP W    53                                                      
REMARK 465     PRO W    54                                                      
REMARK 465     LYS W    55                                                      
REMARK 465     SER W    56                                                      
REMARK 465     ARG W    57                                                      
REMARK 465     GLU W    58                                                      
REMARK 465     GLN W    59                                                      
REMARK 465     MET W    60                                                      
REMARK 465     ILE W    61                                                      
REMARK 465     ASN W    62                                                      
REMARK 465     ASP W    63                                                      
REMARK 465     ARG W    64                                                      
REMARK 465     ILE W    65                                                      
REMARK 465     GLY W    66                                                      
REMARK 465     TYR W    67                                                      
REMARK 465     LYS W    68                                                      
REMARK 465     PRO W    69                                                      
REMARK 465     GLN W    70                                                      
REMARK 465     PRO W    71                                                      
REMARK 465     LYS W    72                                                      
REMARK 465     PRO W    73                                                      
REMARK 465     ASN W    74                                                      
REMARK 465     ASN W    75                                                      
REMARK 465     ARG W    76                                                      
REMARK 465     SER W    77                                                      
REMARK 465     SER W    78                                                      
REMARK 465     GLN W    79                                                      
REMARK 465     PHE W    80                                                      
REMARK 465     GLY W    81                                                      
REMARK 465     SER W    82                                                      
REMARK 465     LEU W    83                                                      
REMARK 465     GLU W    84                                                      
REMARK 465     PHE W    85                                                      
REMARK 465     MET X    35                                                      
REMARK 465     SER X   111                                                      
REMARK 465     LYS X   112                                                      
REMARK 465     THR X   113                                                      
REMARK 465     SER X   114                                                      
REMARK 465     LYS X   115                                                      
REMARK 465     VAL X   116                                                      
REMARK 465     ARG X   117                                                      
REMARK 465     PRO X   118                                                      
REMARK 465     SER X   119                                                      
REMARK 465     THR X   120                                                      
REMARK 465     GLY X   121                                                      
REMARK 465     ASN X   122                                                      
REMARK 465     SER X   123                                                      
REMARK 465     ALA X   124                                                      
REMARK 465     SER X   125                                                      
REMARK 465     THR X   126                                                      
REMARK 465     PRO X   127                                                      
REMARK 465     GLN X   128                                                      
REMARK 465     SER X   129                                                      
REMARK 465     GLN X   130                                                      
REMARK 465     CYS X   131                                                      
REMARK 465     ASN X   541                                                      
REMARK 465     ASP X   542                                                      
REMARK 465     GLN X   543                                                      
REMARK 465     LYS X   544                                                      
REMARK 465     SER X   545                                                      
REMARK 465     LEU X   546                                                      
REMARK 465     GLU X   547                                                      
REMARK 465     GLY X   548                                                      
REMARK 465     MET X   549                                                      
REMARK 465     GLN X   550                                                      
REMARK 465     LYS X   551                                                      
REMARK 465     MET X   552                                                      
REMARK 465     GLU X   553                                                      
REMARK 465     LYS X   554                                                      
REMARK 465     GLU X   555                                                      
REMARK 465     GLU X   556                                                      
REMARK 465     SER X   557                                                      
REMARK 465     PRO X   558                                                      
REMARK 465     THR X   559                                                      
REMARK 465     ASP X   560                                                      
REMARK 465     ALA X   561                                                      
REMARK 465     THR X   562                                                      
REMARK 465     GLN X   563                                                      
REMARK 465     GLU X   564                                                      
REMARK 465     GLU X   565                                                      
REMARK 465     ASP X   566                                                      
REMARK 465     VAL X   567                                                      
REMARK 465     ASP X   568                                                      
REMARK 465     ASP X   569                                                      
REMARK 465     MET X   570                                                      
REMARK 465     GLU X   571                                                      
REMARK 465     GLY X   572                                                      
REMARK 465     SER X   573                                                      
REMARK 465     GLY X   574                                                      
REMARK 465     GLU X   575                                                      
REMARK 465     GLU X   576                                                      
REMARK 465     GLY X   577                                                      
REMARK 465     ASP X   578                                                      
REMARK 465     LEU X   579                                                      
REMARK 465     GLU X   580                                                      
REMARK 465     GLY X   581                                                      
REMARK 465     SER X   582                                                      
REMARK 465     ASP X   583                                                      
REMARK 465     SER X   584                                                      
REMARK 465     GLU X   585                                                      
REMARK 465     ALA X   586                                                      
REMARK 465     ALA X   587                                                      
REMARK 465     GLN X   588                                                      
REMARK 465     TRP X   589                                                      
REMARK 465     ALA X   590                                                      
REMARK 465     ASP X   591                                                      
REMARK 465     GLN X   592                                                      
REMARK 465     GLU X   593                                                      
REMARK 465     GLN X   594                                                      
REMARK 465     TRP X   595                                                      
REMARK 465     PHE X   596                                                      
REMARK 465     GLY X   597                                                      
REMARK 465     MET X   598                                                      
REMARK 465     GLN X   599                                                      
REMARK 465     MET Y    35                                                      
REMARK 465     SER Y   111                                                      
REMARK 465     LYS Y   112                                                      
REMARK 465     THR Y   113                                                      
REMARK 465     SER Y   114                                                      
REMARK 465     LYS Y   115                                                      
REMARK 465     VAL Y   116                                                      
REMARK 465     ARG Y   117                                                      
REMARK 465     PRO Y   118                                                      
REMARK 465     SER Y   119                                                      
REMARK 465     THR Y   120                                                      
REMARK 465     GLY Y   121                                                      
REMARK 465     ASN Y   122                                                      
REMARK 465     SER Y   123                                                      
REMARK 465     ALA Y   124                                                      
REMARK 465     SER Y   125                                                      
REMARK 465     THR Y   126                                                      
REMARK 465     PRO Y   127                                                      
REMARK 465     GLN Y   128                                                      
REMARK 465     SER Y   129                                                      
REMARK 465     GLN Y   130                                                      
REMARK 465     CYS Y   131                                                      
REMARK 465     GLU Y   553                                                      
REMARK 465     LYS Y   554                                                      
REMARK 465     GLU Y   555                                                      
REMARK 465     GLU Y   556                                                      
REMARK 465     SER Y   557                                                      
REMARK 465     PRO Y   558                                                      
REMARK 465     THR Y   559                                                      
REMARK 465     ASP Y   560                                                      
REMARK 465     ALA Y   561                                                      
REMARK 465     THR Y   562                                                      
REMARK 465     GLN Y   563                                                      
REMARK 465     GLU Y   564                                                      
REMARK 465     GLU Y   565                                                      
REMARK 465     ASP Y   566                                                      
REMARK 465     VAL Y   567                                                      
REMARK 465     ASP Y   568                                                      
REMARK 465     ASP Y   569                                                      
REMARK 465     MET Y   570                                                      
REMARK 465     GLU Y   571                                                      
REMARK 465     GLY Y   572                                                      
REMARK 465     SER Y   573                                                      
REMARK 465     GLY Y   574                                                      
REMARK 465     GLU Y   575                                                      
REMARK 465     GLU Y   576                                                      
REMARK 465     GLY Y   577                                                      
REMARK 465     ASP Y   578                                                      
REMARK 465     LEU Y   579                                                      
REMARK 465     GLU Y   580                                                      
REMARK 465     GLY Y   581                                                      
REMARK 465     SER Y   582                                                      
REMARK 465     ASP Y   583                                                      
REMARK 465     SER Y   584                                                      
REMARK 465     GLU Y   585                                                      
REMARK 465     ALA Y   586                                                      
REMARK 465     ALA Y   587                                                      
REMARK 465     GLN Y   588                                                      
REMARK 465     TRP Y   589                                                      
REMARK 465     ALA Y   590                                                      
REMARK 465     ASP Y   591                                                      
REMARK 465     GLN Y   592                                                      
REMARK 465     GLU Y   593                                                      
REMARK 465     GLN Y   594                                                      
REMARK 465     TRP Y   595                                                      
REMARK 465     PHE Y   596                                                      
REMARK 465     GLY Y   597                                                      
REMARK 465     MET Y   598                                                      
REMARK 465     GLN Y   599                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LEU A  48    CG   CD1  CD2                                       
REMARK 470     TRP A  49    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP A  49    CZ3  CH2                                            
REMARK 470     SER A  50    OG                                                  
REMARK 470     SER A  51    OG                                                  
REMARK 470     ASP A  52    CG   OD1  OD2                                       
REMARK 470     LEU A  57    CG   CD1  CD2                                       
REMARK 470     VAL A  58    CG1  CG2                                            
REMARK 470     LYS A  71    CG   CD   CE   NZ                                   
REMARK 470     GLU A  82    CG   CD   OE1  OE2                                  
REMARK 470     ILE A  83    CG1  CG2  CD1                                       
REMARK 470     GLN A 109    CG   CD   OE1  NE2                                  
REMARK 470     GLU A 146    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 148    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 184    CG   CD   CE   NZ                                   
REMARK 470     PRO A 206    CG   CD                                             
REMARK 470     GLU A 219    CG   CD   OE1  OE2                                  
REMARK 470     VAL A 236    CG1  CG2                                            
REMARK 470     ASP A 241    CG   OD1  OD2                                       
REMARK 470     ASN A 264    CG   OD1  ND2                                       
REMARK 470     LYS A 275    CG   CD   CE   NZ                                   
REMARK 470     SER A 276    OG                                                  
REMARK 470     GLU A 277    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 278    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 279    CG   CD   OE1  OE2                                  
REMARK 470     ASN A 280    CG   OD1  ND2                                       
REMARK 470     VAL A 281    CG1  CG2                                            
REMARK 470     VAL A 282    CG1  CG2                                            
REMARK 470     LEU A 283    CG   CD1  CD2                                       
REMARK 470     LYS A 284    CG   CD   CE   NZ                                   
REMARK 470     PHE A 285    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER A 286    OG                                                  
REMARK 470     GLU A 287    CG   CD   OE1  OE2                                  
REMARK 470     GLN A 288    CG   CD   OE1  NE2                                  
REMARK 470     PRO A 292    CG   CD                                             
REMARK 470     GLN A 293    CG   CD   OE1  NE2                                  
REMARK 470     ASN A 294    CG   OD1  ND2                                       
REMARK 470     VAL A 295    CG1  CG2                                            
REMARK 470     CYS A 408    SG                                                  
REMARK 470     THR A 414    OG1  CG2                                            
REMARK 470     ASN A 424    CG   OD1  ND2                                       
REMARK 470     SER A 425    OG                                                  
REMARK 470     GLU A 447    CG   CD   OE1  OE2                                  
REMARK 470     GLN A 465    CG   CD   OE1  NE2                                  
REMARK 470     LYS A 484    CG   CD   CE   NZ                                   
REMARK 470     ASP A 486    CG   OD1  OD2                                       
REMARK 470     GLU A 492    CG   CD   OE1  OE2                                  
REMARK 470     SER A 494    OG                                                  
REMARK 470     LYS A 631    CG   CD   CE   NZ                                   
REMARK 470     GLU A 632    CG   CD   OE1  OE2                                  
REMARK 470     PRO A 651    CG   CD                                             
REMARK 470     TYR A 670    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     VAL A 814    CG1  CG2                                            
REMARK 470     SER A 839    OG                                                  
REMARK 470     GLU A 840    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 855    CG   CD   OE1  OE2                                  
REMARK 470     MET A 857    CG   SD   CE                                        
REMARK 470     LYS A 985    CG   CD   CE   NZ                                   
REMARK 470     GLN A 986    CG   CD   OE1  NE2                                  
REMARK 470     TYR A1054    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU A1056    CG   CD   OE1  OE2                                  
REMARK 470     GLU A1059    CG   CD   OE1  OE2                                  
REMARK 470     GLU A1098    CG   CD   OE1  OE2                                  
REMARK 470     ASP A1126    CG   OD1  OD2                                       
REMARK 470     MET A1285    CG   SD   CE                                        
REMARK 470     GLU A1286    CG   CD   OE1  OE2                                  
REMARK 470     CYS A1288    SG                                                  
REMARK 470     ASP A1318    CG   OD1  OD2                                       
REMARK 470     ASP A1356    CG   OD1  OD2                                       
REMARK 470     THR A1357    OG1  CG2                                            
REMARK 470     MET A1393    CG   SD   CE                                        
REMARK 470     GLU A1402    CG   CD   OE1  OE2                                  
REMARK 470     ASP A1418    CG   OD1  OD2                                       
REMARK 470     ASN A1422    CG   OD1  ND2                                       
REMARK 470     ARG A1435    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A1436    CG   CD   OE1  OE2                                  
REMARK 470     ASN A1437    CG   OD1  ND2                                       
REMARK 470     LEU A1452    CG   CD1  CD2                                       
REMARK 470     GLU A1549    CG   CD   OE1  OE2                                  
REMARK 470     GLU A1659    CG   CD   OE1  OE2                                  
REMARK 470     LEU A1680    CG   CD1  CD2                                       
REMARK 470     LYS A1709    CG   CD   CE   NZ                                   
REMARK 470     ASN A1727    CG   OD1  ND2                                       
REMARK 470     ASN A1763    CG   OD1  ND2                                       
REMARK 470     LYS A1767    CG   CD   CE   NZ                                   
REMARK 470     ARG A1806    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS A1829    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLN A1830    CG   CD   OE1  NE2                                  
REMARK 470     GLU A1846    CG   CD   OE1  OE2                                  
REMARK 470     VAL A1865    CG1  CG2                                            
REMARK 470     GLU A1882    CG   CD   OE1  OE2                                  
REMARK 470     LEU A1892    CG   CD1  CD2                                       
REMARK 470     SER A1911    OG                                                  
REMARK 470     THR A1912    OG1  CG2                                            
REMARK 470     SER A1913    OG                                                  
REMARK 470     PHE A1914    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU A1916    CG   CD   OE1  OE2                                  
REMARK 470     LEU A1917    CG   CD1  CD2                                       
REMARK 470     LEU A1918    CG   CD1  CD2                                       
REMARK 470     PHE A1919    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS A1920    CG   CD   CE   NZ                                   
REMARK 470     PHE A1921    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS A1922    CG   CD   CE   NZ                                   
REMARK 470     GLN A1923    CG   CD   OE1  NE2                                  
REMARK 470     LEU A1924    CG   CD1  CD2                                       
REMARK 470     LYS A1925    CG   CD   CE   NZ                                   
REMARK 470     MET A1926    CG   SD   CE                                        
REMARK 470     PRO A1927    CG   CD                                             
REMARK 470     VAL A1928    CG1  CG2                                            
REMARK 470     ARG A1929    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU A1931    CG   CD1  CD2                                       
REMARK 470     LEU A1932    CG   CD1  CD2                                       
REMARK 470     ARG A1933    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU A1934    CG   CD1  CD2                                       
REMARK 470     ASN B  19    CG   OD1  ND2                                       
REMARK 470     ASP B  20    CG   OD1  OD2                                       
REMARK 470     GLU B  21    CG   CD   OE1  OE2                                  
REMARK 470     ASN B  22    CG   OD1  ND2                                       
REMARK 470     LYS B  38    CG   CD   CE   NZ                                   
REMARK 470     VAL B  39    CG1  CG2                                            
REMARK 470     PRO B  40    CG   CD                                             
REMARK 470     ASP B  42    CG   OD1  OD2                                       
REMARK 470     GLN B  67    CG   CD   OE1  NE2                                  
REMARK 470     GLN B  68    CG   CD   OE1  NE2                                  
REMARK 470     GLN B  70    CG   CD   OE1  NE2                                  
REMARK 470     GLU C  69    CG   CD   OE1  OE2                                  
REMARK 470     CYS C 109    SG                                                  
REMARK 470     LYS C 281    CG   CD   CE   NZ                                   
REMARK 470     ASP C 496    CG   OD1  OD2                                       
REMARK 470     SER C 499    OG                                                  
REMARK 470     CYS C 500    SG                                                  
REMARK 470     ASP D  21    CG   OD1  OD2                                       
REMARK 470     ARG D  22    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO D  23    CG   CD                                             
REMARK 470     CYS D  24    SG                                                  
REMARK 470     LEU D  51    CG   CD1  CD2                                       
REMARK 470     LYS D  56    CG   CD   CE   NZ                                   
REMARK 470     ARG E  52    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU E  54    CG   CD1  CD2                                       
REMARK 470     CYS E  55    SG                                                  
REMARK 470     GLN F   5    CG   CD   OE1  NE2                                  
REMARK 470     PHE F 168    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS F 169    CG   CD   CE   NZ                                   
REMARK 470     PHE F 170    CB   CG   CD1  CD2  CE1  CE2  CZ                    
REMARK 470     PHE F 452    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASN F 453    CG   OD1  ND2                                       
REMARK 470     LEU F 454    CG   CD1  CD2                                       
REMARK 470     LYS F 456    CG   CD   CE   NZ                                   
REMARK 470     SER F 475    OG                                                  
REMARK 470     SER F 484    OG                                                  
REMARK 470     ASP F 767    CG   OD1  OD2                                       
REMARK 470     PRO F 768    CG   CD                                             
REMARK 470     LYS F 769    CG   CD   CE   NZ                                   
REMARK 470     ASN F 778    CG   OD1  ND2                                       
REMARK 470     ASN F 810    CG   OD1  ND2                                       
REMARK 470     GLN F 811    CG   CD   OE1  NE2                                  
REMARK 470     ILE F 812    CG1  CG2  CD1                                       
REMARK 470     LYS F 813    CG   CD   CE   NZ                                   
REMARK 470     GLU F 814    CG   CD   OE1  OE2                                  
REMARK 470     ILE F 816    CG1  CG2  CD1                                       
REMARK 470     ASP F 817    CG   OD1  OD2                                       
REMARK 470     LYS F 818    CG   CD   CE   NZ                                   
REMARK 470     ARG F 819    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS G  24    CG   CD   CE   NZ                                   
REMARK 470     ASP G  25    CG   OD1  OD2                                       
REMARK 470     GLN H   5    CG   CD   OE1  NE2                                  
REMARK 470     PHE H 168    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS H 169    CG   CD   CE   NZ                                   
REMARK 470     PHE H 170    CB   CG   CD1  CD2  CE1  CE2  CZ                    
REMARK 470     PHE H 452    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASN H 453    CG   OD1  ND2                                       
REMARK 470     LEU H 454    CG   CD1  CD2                                       
REMARK 470     SER H 475    OG                                                  
REMARK 470     SER H 484    OG                                                  
REMARK 470     ASP H 771    CG   OD1  OD2                                       
REMARK 470     PHE I 128    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TYR I 129    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU I 132    CD   OE1  OE2                                       
REMARK 470     ASP I 133    CG   OD1  OD2                                       
REMARK 470     ASN I 136    CG   OD1  ND2                                       
REMARK 470     LYS I 147    CG   CD   CE   NZ                                   
REMARK 470     ASN I 148    CG   OD1  ND2                                       
REMARK 470     TYR I 149    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN I 151    CG   OD1  ND2                                       
REMARK 470     THR I 152    OG1  CG2                                            
REMARK 470     LYS I 154    CG   CD   CE   NZ                                   
REMARK 470     GLU I 159    CG   CD   OE1  OE2                                  
REMARK 470     ASN I 160    CG   OD1  ND2                                       
REMARK 470     GLN I 292    CG   CD   OE1  NE2                                  
REMARK 470     GLU I 293    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 294    CG   CD   CE   NZ                                   
REMARK 470     ASN I 295    CG   OD1  ND2                                       
REMARK 470     THR I 296    OG1  CG2                                            
REMARK 470     THR I 297    OG1  CG2                                            
REMARK 470     THR I 298    OG1  CG2                                            
REMARK 470     SER I 299    OG                                                  
REMARK 470     LYS I 346    CG   CD   CE   NZ                                   
REMARK 470     GLU I 402    CG   CD   OE1  OE2                                  
REMARK 470     MET I 411    CG   SD   CE                                        
REMARK 470     LYS I 412    CG   CD   CE   NZ                                   
REMARK 470     ASP I 430    CG   OD1  OD2                                       
REMARK 470     LYS I 439    CG   CD   CE   NZ                                   
REMARK 470     PHE I 470    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS I 480    CG   CD   CE   NZ                                   
REMARK 470     ASP I 481    CG   OD1  OD2                                       
REMARK 470     GLU I 482    CG   CD   OE1  OE2                                  
REMARK 470     ASP I 483    CG   OD1  OD2                                       
REMARK 470     ASP I 484    CG   OD1  OD2                                       
REMARK 470     ASP I 485    CG   OD1  OD2                                       
REMARK 470     LEU I 486    CG   CD1  CD2                                       
REMARK 470     VAL I 487    CG1  CG2                                            
REMARK 470     SER I 488    OG                                                  
REMARK 470     ASN I 495    CG   OD1  ND2                                       
REMARK 470     ARG I 567    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG I 659    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU I 660    CG   CD   OE1  OE2                                  
REMARK 470     ARG I 662    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU I 756    CG   CD   OE1  OE2                                  
REMARK 470     ASN J   2    CG   OD1  ND2                                       
REMARK 470     LEU J   3    CG   CD1  CD2                                       
REMARK 470     GLU J   4    CG   CD   OE1  OE2                                  
REMARK 470     ARG J   5    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER J 124    OG                                                  
REMARK 470     GLN J 125    CG   CD   OE1  NE2                                  
REMARK 470     SER J 126    OG                                                  
REMARK 470     GLU J 222    CG   CD   OE1  OE2                                  
REMARK 470     GLU J 347    CG   CD   OE1  OE2                                  
REMARK 470     GLU J 524    CG   CD   OE1  OE2                                  
REMARK 470     ASP J 529    CG   OD1  OD2                                       
REMARK 470     SER J 530    OG                                                  
REMARK 470     GLU J 531    CG   CD   OE1  OE2                                  
REMARK 470     ASN K   2    CG   OD1  ND2                                       
REMARK 470     LEU K   3    CG   CD1  CD2                                       
REMARK 470     GLU K   4    CG   CD   OE1  OE2                                  
REMARK 470     ARG K   5    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS K 214    CG   CD   CE   NZ                                   
REMARK 470     GLU K 228    CG   CD   OE1  OE2                                  
REMARK 470     SER L 164    OG                                                  
REMARK 470     SER L 165    OG                                                  
REMARK 470     ILE L 166    CG1  CG2  CD1                                       
REMARK 470     LYS L 168    CG   CD   CE   NZ                                   
REMARK 470     PHE L 169    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PRO L 170    CG   CD                                             
REMARK 470     ARG L 171    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     CYS L 172    SG                                                  
REMARK 470     THR L 173    OG1  CG2                                            
REMARK 470     THR L 174    OG1  CG2                                            
REMARK 470     ILE L 175    CG1  CG2  CD1                                       
REMARK 470     ASP L 176    CG   OD1  OD2                                       
REMARK 470     ARG N  15    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO N  16    CG   CD                                             
REMARK 470     GLN N  18    CG   CD   OE1  NE2                                  
REMARK 470     GLU N  19    CG   CD   OE1  OE2                                  
REMARK 470     LEU N  20    CG   CD1  CD2                                       
REMARK 470     LEU N  21    CG   CD1  CD2                                       
REMARK 470     VAL N  22    CG1  CG2                                            
REMARK 470     TRP N  24    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP N  24    CZ3  CH2                                            
REMARK 470     ASN N  25    CG   OD1  ND2                                       
REMARK 470     THR N  26    OG1  CG2                                            
REMARK 470     VAL N  27    CG1  CG2                                            
REMARK 470     SER N  28    OG                                                  
REMARK 470     THR N  29    OG1  CG2                                            
REMARK 470     GLU N  53    CG   CD   OE1  OE2                                  
REMARK 470     GLU N  54    CG   CD   OE1  OE2                                  
REMARK 470     LEU N  55    CG   CD1  CD2                                       
REMARK 470     ARG N  56    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL N  59    CG1  CG2                                            
REMARK 470     GLU N  60    CG   CD   OE1  OE2                                  
REMARK 470     VAL N  61    CG1  CG2                                            
REMARK 470     LEU N  62    CG   CD1  CD2                                       
REMARK 470     ARG N  63    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS N  65    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL N  70    CG1  CG2                                            
REMARK 470     LEU N  71    CG   CD1  CD2                                       
REMARK 470     GLU N  72    CG   CD   OE1  OE2                                  
REMARK 470     GLU N  73    CG   CD   OE1  OE2                                  
REMARK 470     ASN N  93    CG   OD1  ND2                                       
REMARK 470     ILE N  95    CG1  CG2  CD1                                       
REMARK 470     SER N  96    OG                                                  
REMARK 470     GLN N  97    CG   CD   OE1  NE2                                  
REMARK 470     CYS N  98    SG                                                  
REMARK 470     GLU N  99    CG   CD   OE1  OE2                                  
REMARK 470     ASN N 100    CG   OD1  ND2                                       
REMARK 470     SER N 101    OG                                                  
REMARK 470     CYS N 107    SG                                                  
REMARK 470     LEU N 108    CG   CD1  CD2                                       
REMARK 470     LEU N 109    CG   CD1  CD2                                       
REMARK 470     LEU N 110    CG   CD1  CD2                                       
REMARK 470     LEU N 111    CG   CD1  CD2                                       
REMARK 470     LEU N 112    CG   CD1  CD2                                       
REMARK 470     ASP N 113    CG   OD1  OD2                                       
REMARK 470     PHE N 115    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU N 117    CG   CD1  CD2                                       
REMARK 470     LEU N 118    CG   CD1  CD2                                       
REMARK 470     GLU N 119    CG   CD   OE1  OE2                                  
REMARK 470     SER N 120    OG                                                  
REMARK 470     ARG N 121    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU N 122    CG   CD1  CD2                                       
REMARK 470     ASP N 123    CG   OD1  OD2                                       
REMARK 470     LEU N 126    CG   CD1  CD2                                       
REMARK 470     ARG N 127    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER N 128    OG                                                  
REMARK 470     GLU N 130    CG   CD   OE1  OE2                                  
REMARK 470     LEU N 131    CG   CD1  CD2                                       
REMARK 470     LEU N 132    CG   CD1  CD2                                       
REMARK 470     GLU N 133    CG   CD   OE1  OE2                                  
REMARK 470     LYS N 134    CG   CD   CE   NZ                                   
REMARK 470     TRP N 135    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP N 135    CZ3  CH2                                            
REMARK 470     THR N 136    OG1  CG2                                            
REMARK 470     ARG N 137    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU N 138    CG   CD1  CD2                                       
REMARK 470     LEU N 140    CG   CD1  CD2                                       
REMARK 470     LEU N 141    CG   CD1  CD2                                       
REMARK 470     MET N 142    CG   SD   CE                                        
REMARK 470     THR N 144    OG1  CG2                                            
REMARK 470     GLN N 147    CG   CD   OE1  NE2                                  
REMARK 470     SER N 164    OG                                                  
REMARK 470     THR N 165    OG1  CG2                                            
REMARK 470     ASP N 196    CG   OD1  OD2                                       
REMARK 470     PRO N 197    CG   CD                                             
REMARK 470     GLU N 198    CG   CD   OE1  OE2                                  
REMARK 470     LEU N 199    CG   CD1  CD2                                       
REMARK 470     GLU N 200    CG   CD   OE1  OE2                                  
REMARK 470     LEU N 216    CG   CD1  CD2                                       
REMARK 470     GLN N 217    CG   CD   OE1  NE2                                  
REMARK 470     SER N 218    OG                                                  
REMARK 470     PRO N 219    CG   CD                                             
REMARK 470     LEU N 220    CG   CD1  CD2                                       
REMARK 470     GLU N 254    CG   CD   OE1  OE2                                  
REMARK 470     GLU N 294    CG   CD   OE1  OE2                                  
REMARK 470     ARG N 349    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR N 443    OG1  CG2                                            
REMARK 470     ASP N 451    CG   OD1  OD2                                       
REMARK 470     LEU N 452    CG   CD1  CD2                                       
REMARK 470     VAL N 454    CG1  CG2                                            
REMARK 470     GLU N 455    CG   CD   OE1  OE2                                  
REMARK 470     LEU N 456    CG   CD1  CD2                                       
REMARK 470     SER N 457    OG                                                  
REMARK 470     LYS N 458    CG   CD   CE   NZ                                   
REMARK 470     GLU N 476    CG   CD   OE1  OE2                                  
REMARK 470     PRO N 477    CG   CD                                             
REMARK 470     GLU N 478    CG   CD   OE1  OE2                                  
REMARK 470     ASP N 479    CG   OD1  OD2                                       
REMARK 470     TRP N 480    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP N 480    CZ3  CH2                                            
REMARK 470     VAL N 481    CG1  CG2                                            
REMARK 470     PRO N 482    CG   CD                                             
REMARK 470     ASP N 483    CG   OD1  OD2                                       
REMARK 470     PRO N 484    CG   CD                                             
REMARK 470     VAL N 485    CG1  CG2                                            
REMARK 470     ASP N 486    CG   OD1  OD2                                       
REMARK 470     ASP N 488    CG   OD1  OD2                                       
REMARK 470     PRO N 489    CG   CD                                             
REMARK 470     LYS N 491    CG   CD   CE   NZ                                   
REMARK 470     SER N 492    OG                                                  
REMARK 470     SER N 493    OG                                                  
REMARK 470     SER N 494    OG                                                  
REMARK 470     LYS N 495    CG   CD   CE   NZ                                   
REMARK 470     ARG N 496    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG N 497    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER N 499    OG                                                  
REMARK 470     LYS O  27    CG   CD   CE   NZ                                   
REMARK 470     THR O  47    OG1  CG2                                            
REMARK 470     GLU O  49    CG   CD   OE1  OE2                                  
REMARK 470     VAL O  52    CG1  CG2                                            
REMARK 470     THR O 122    OG1  CG2                                            
REMARK 470     GLU O 123    CG   CD   OE1  OE2                                  
REMARK 470     LYS O 168    CG   CD   CE   NZ                                   
REMARK 470     LYS O 169    CG   CD   CE   NZ                                   
REMARK 470     LYS O 229    CG   CD   CE   NZ                                   
REMARK 470     GLU O 452    CG   CD   OE1  OE2                                  
REMARK 470     GLN O 742    CG   CD   OE1  NE2                                  
REMARK 470     GLU O 743    CG   CD   OE1  OE2                                  
REMARK 470     SER O 746    OG                                                  
REMARK 470     VAL O 749    CG1  CG2                                            
REMARK 470     GLU P  69    CG   CD   OE1  OE2                                  
REMARK 470     CYS P 109    SG                                                  
REMARK 470     LYS P 281    CG   CD   CE   NZ                                   
REMARK 470     ASP P 496    CG   OD1  OD2                                       
REMARK 470     ILE P 497    CD1                                                 
REMARK 470     SER P 499    OG                                                  
REMARK 470     CYS P 500    SG                                                  
REMARK 470     LYS R 125    CG   CD   CE   NZ                                   
REMARK 470     SER R 163    OG                                                  
REMARK 470     VAL R 483    CG1  CG2                                            
REMARK 470     VAL S 319    CG1  CG2                                            
REMARK 470     MET S 320    CG   SD   CE                                        
REMARK 470     PRO S 324    CG   CD                                             
REMARK 470     TYR S 356    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     SER S 357    OG                                                  
REMARK 470     ARG S 358    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS S 359    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS S 367    CG   CD   CE   NZ                                   
REMARK 470     THR S 368    OG1  CG2                                            
REMARK 470     LEU S 369    CG   CD1  CD2                                       
REMARK 470     LYS S 370    CG   CD   CE   NZ                                   
REMARK 470     LYS S 371    CG   CD   CE   NZ                                   
REMARK 470     ASN S 372    CG   OD1  ND2                                       
REMARK 470     GLU S 373    CG   CD   OE1  OE2                                  
REMARK 470     LYS S 376    CG   CD   CE   NZ                                   
REMARK 470     SER S 420    OG                                                  
REMARK 470     ASP S 421    CG   OD1  OD2                                       
REMARK 470     LYS S 423    CG   CD   CE   NZ                                   
REMARK 470     LEU S 424    CG   CD1  CD2                                       
REMARK 470     LEU S 425    CG   CD1  CD2                                       
REMARK 470     LYS S 426    CG   CD   CE   NZ                                   
REMARK 470     SER S 428    OG                                                  
REMARK 470     CYS S 429    SG                                                  
REMARK 470     LYS S 430    CG   CD   CE   NZ                                   
REMARK 470     ILE S 431    CG1  CG2  CD1                                       
REMARK 470     PRO S 433    CG   CD                                             
REMARK 470     LEU S 434    CG   CD1  CD2                                       
REMARK 470     PRO S 435    CG   CD                                             
REMARK 470     LEU T   7    CG   CD1  CD2                                       
REMARK 470     MET U   5    CG   SD   CE                                        
REMARK 470     SER U   6    OG                                                  
REMARK 470     ARG U   7    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG U   8    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO U   9    CG   CD                                             
REMARK 470     CYS U  10    SG                                                  
REMARK 470     SER U  11    OG                                                  
REMARK 470     CYS U  12    SG                                                  
REMARK 470     LEU U  14    CG   CD1  CD2                                       
REMARK 470     ARG U  15    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO U  16    CG   CD                                             
REMARK 470     PRO U  17    CG   CD                                             
REMARK 470     LYS W  24    CG   CD   CE   NZ                                   
REMARK 470     ASP W  25    CG   OD1  OD2                                       
REMARK 470     LYS X 215    CG   CD   CE   NZ                                   
REMARK 470     GLU X 218    CG   CD   OE1  OE2                                  
REMARK 470     MET X 224    CG   SD   CE                                        
REMARK 470     ASN X 225    CG   OD1  ND2                                       
REMARK 470     GLN X 228    CG   CD   OE1  NE2                                  
REMARK 470     ARG X 317    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU X 318    CG   CD   OE1  OE2                                  
REMARK 470     ASN X 440    CG   OD1  ND2                                       
REMARK 470     LYS Y 215    CG   CD   CE   NZ                                   
REMARK 470     GLU Y 218    CG   CD   OE1  OE2                                  
REMARK 470     MET Y 224    CG   SD   CE                                        
REMARK 470     ASN Y 225    CG   OD1  ND2                                       
REMARK 470     GLN Y 228    CG   CD   OE1  NE2                                  
REMARK 470     ARG Y 317    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU Y 318    CG   CD   OE1  OE2                                  
REMARK 470     ASN Y 440    CG   OD1  ND2                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   CD   GLN R   310     CD2  LEU R   338              0.85            
REMARK 500   O    PRO R   431     N    SER R   432              0.86            
REMARK 500   CE1  TYR X   355     N    ASN X   385              0.94            
REMARK 500   CG   GLN R   310     CD2  LEU R   338              0.95            
REMARK 500   CZ   TYR X   355     N    ASN X   385              0.96            
REMARK 500   SD   MET R   292     CD2  LEU R   309              1.03            
REMARK 500   CE1  TYR R   189     CB   GLU R   315              1.04            
REMARK 500   CZ   TYR X   355     C    ARG X   384              1.06            
REMARK 500   CD2  LEU R   267     CD1  LEU R   303              1.32            
REMARK 500   CE   MET R   292     NE   ARG R   307              1.32            
REMARK 500   OD2  ASP L   126     O    LYS L   130              1.41            
REMARK 500   O    LEU X   359     CE   LYS X   379              1.45            
REMARK 500   OD1  ASN R   280     ND1  HIS R   325              1.48            
REMARK 500   O    GLN R   310     N    GLY R   311              1.51            
REMARK 500   CZ   TYR R   189     CG   GLU R   315              1.51            
REMARK 500   CZ   TYR X   355     O    ARG X   384              1.52            
REMARK 500   N    SER O    76     OD1  ASP O   165              1.53            
REMARK 500   NE2  GLN R   310     CD2  LEU R   338              1.54            
REMARK 500   O    VAL R   178     O    SER S   327              1.57            
REMARK 500   O    ASP R   230     O    SER R   231              1.57            
REMARK 500   O    PRO R   431     CA   SER R   432              1.57            
REMARK 500   CD   PRO R   431     CB   LEU R   433              1.61            
REMARK 500   O    VAL R   227     OD1  ASP R   230              1.61            
REMARK 500   OE1  GLN R   310     CH2  TRP R   340              1.62            
REMARK 500   CE1  TYR X   355     C    ARG X   384              1.64            
REMARK 500   OG1  THR R   434     N    GLN R   435              1.67            
REMARK 500   CE2  TYR X   355     O    ARG X   384              1.69            
REMARK 500   OH   TYR R   189     CG   GLU R   315              1.71            
REMARK 500   OH   TYR X   355     N    ASN X   385              1.71            
REMARK 500   OH   TYR X   355     C    ARG X   384              1.73            
REMARK 500   CD1  TYR X   355     O    ALA X   382              1.74            
REMARK 500   O    LYS R   429     O    LEU R   433              1.75            
REMARK 500   OH   TYR X   355     O    ARG X   384              1.77            
REMARK 500   O    VAL N    78     N    ASN N    81              1.77            
REMARK 500   CZ   TYR R   189     CB   GLU R   315              1.78            
REMARK 500   CD1  TYR R   189     N    VAL R   316              1.79            
REMARK 500   CB   CYS R   317     O    GLY R   331              1.79            
REMARK 500   CZ   TYR X   355     CA   ASN X   385              1.80            
REMARK 500   O    LEU O   222     O    ASP O   226              1.81            
REMARK 500   NE2  GLN R   310     CG   LEU R   338              1.82            
REMARK 500   OE2  GLU H   537     OE1  GLU H   568              1.82            
REMARK 500   CA   TYR X   355     O    ALA X   382              1.83            
REMARK 500   CD1  TYR R   189     CB   GLU R   315              1.83            
REMARK 500   CD2  TYR X   355     N    MET X   386              1.83            
REMARK 500   O    PHE N    91     N    ASN N    93              1.84            
REMARK 500   CB   TYR X   355     O    ALA X   382              1.85            
REMARK 500   O    LYS X   491     OD1  ASP X   494              1.87            
REMARK 500   O    LYS Y   491     OD1  ASP Y   494              1.87            
REMARK 500   CD   GLN R   310     CG   LEU R   338              1.90            
REMARK 500   OD1  ASN R   280     CG   HIS R   325              1.91            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     103 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    TRP C 402   CB    TRP C 402   CG     -0.113                       
REMARK 500    TRP F 570   CB    TRP F 570   CG     -0.127                       
REMARK 500    TRP H 570   CB    TRP H 570   CG     -0.110                       
REMARK 500    LYS J 229   CB    LYS J 229   CG     -0.177                       
REMARK 500    TRP J 302   CB    TRP J 302   CG     -0.162                       
REMARK 500    TRP J 337   CB    TRP J 337   CG     -0.151                       
REMARK 500    LYS K 229   CB    LYS K 229   CG      0.894                       
REMARK 500    TRP K 302   CB    TRP K 302   CG     -0.115                       
REMARK 500    TRP N 299   CE3   TRP N 299   CZ3    -0.115                       
REMARK 500    TRP O 346   CB    TRP O 346   CG     -0.142                       
REMARK 500    TRP P 402   CB    TRP P 402   CG     -0.115                       
REMARK 500    CYS R 208   CB    CYS R 208   SG     -0.392                       
REMARK 500    CYS R 215   CB    CYS R 215   SG     -0.392                       
REMARK 500    CYS R 223   CB    CYS R 223   SG     -0.392                       
REMARK 500    PRO R 301   CD    PRO R 301   N       0.665                       
REMARK 500    PRO R 302   CD    PRO R 302   N       0.686                       
REMARK 500    CYS R 317   CB    CYS R 317   SG     -0.393                       
REMARK 500    CYS R 381   CB    CYS R 381   SG     -0.392                       
REMARK 500    PRO R 392   CD    PRO R 392   N       0.712                       
REMARK 500    CYS R 395   CB    CYS R 395   SG     -0.392                       
REMARK 500    CYS R 403   CB    CYS R 403   SG     -0.392                       
REMARK 500    PRO R 431   CD    PRO R 431   N       0.753                       
REMARK 500    TYR X 355   CE1   TYR X 355   CZ      0.115                       
REMARK 500    ASN X 385   N     ASN X 385   CA      0.196                       
REMARK 500    MET X 386   N     MET X 386   CA      0.124                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    PRO A 292   N   -  CA  -  CB  ANGL. DEV. =   8.1 DEGREES          
REMARK 500    MET A 665   CG  -  SD  -  CE  ANGL. DEV. =  11.3 DEGREES          
REMARK 500    MET A1019   CG  -  SD  -  CE  ANGL. DEV. =  10.3 DEGREES          
REMARK 500    CYS A1074   CA  -  CB  -  SG  ANGL. DEV. = -10.9 DEGREES          
REMARK 500    ARG A1084   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.1 DEGREES          
REMARK 500    MET A1203   CG  -  SD  -  CE  ANGL. DEV. =  -9.8 DEGREES          
REMARK 500    ARG A1540   NE  -  CZ  -  NH1 ANGL. DEV. =   8.2 DEGREES          
REMARK 500    ARG A1540   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.5 DEGREES          
REMARK 500    PRO A1927   N   -  CA  -  CB  ANGL. DEV. =   7.3 DEGREES          
REMARK 500    PRO B  40   N   -  CA  -  CB  ANGL. DEV. =   7.2 DEGREES          
REMARK 500    PHE C  26   CB  -  CG  -  CD2 ANGL. DEV. =  -5.0 DEGREES          
REMARK 500    PHE C  26   CB  -  CG  -  CD1 ANGL. DEV. =   5.1 DEGREES          
REMARK 500    ARG C 423   NE  -  CZ  -  NH1 ANGL. DEV. =   3.2 DEGREES          
REMARK 500    ARG C 424   NE  -  CZ  -  NH1 ANGL. DEV. =   3.2 DEGREES          
REMARK 500    LEU C 516   CA  -  CB  -  CG  ANGL. DEV. =  14.7 DEGREES          
REMARK 500    PRO D  23   N   -  CA  -  CB  ANGL. DEV. =   7.3 DEGREES          
REMARK 500    ARG F 625   NE  -  CZ  -  NH1 ANGL. DEV. =   3.0 DEGREES          
REMARK 500    PRO F 768   N   -  CA  -  CB  ANGL. DEV. =   8.5 DEGREES          
REMARK 500    ARG H  50   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.1 DEGREES          
REMARK 500    ARG H 467   NE  -  CZ  -  NH1 ANGL. DEV. =   3.0 DEGREES          
REMARK 500    VAL I 223   CB  -  CA  -  C   ANGL. DEV. = -11.7 DEGREES          
REMARK 500    PRO I 489   C   -  N   -  CA  ANGL. DEV. =   9.0 DEGREES          
REMARK 500    ARG J  61   NE  -  CZ  -  NH1 ANGL. DEV. =   3.7 DEGREES          
REMARK 500    ARG J  61   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.3 DEGREES          
REMARK 500    PRO J 221   C   -  N   -  CD  ANGL. DEV. = -15.7 DEGREES          
REMARK 500    LEU J 294   CB  -  CG  -  CD2 ANGL. DEV. =  10.9 DEGREES          
REMARK 500    LYS K 229   CA  -  CB  -  CG  ANGL. DEV. = -29.2 DEGREES          
REMARK 500    LYS K 229   CB  -  CG  -  CD  ANGL. DEV. = -21.8 DEGREES          
REMARK 500    ARG K 510   NE  -  CZ  -  NH1 ANGL. DEV. =   3.6 DEGREES          
REMARK 500    CYS L  36   CA  -  CB  -  SG  ANGL. DEV. =   6.8 DEGREES          
REMARK 500    THR L 132   CB  -  CA  -  C   ANGL. DEV. = -19.6 DEGREES          
REMARK 500    ARG N  63   N   -  CA  -  C   ANGL. DEV. =  20.1 DEGREES          
REMARK 500    GLY N  64   C   -  N   -  CA  ANGL. DEV. =  14.0 DEGREES          
REMARK 500    ARG N 425   NE  -  CZ  -  NH1 ANGL. DEV. =   4.9 DEGREES          
REMARK 500    PRO N 477   N   -  CA  -  CB  ANGL. DEV. =   7.8 DEGREES          
REMARK 500    PRO N 489   N   -  CA  -  CB  ANGL. DEV. =  12.5 DEGREES          
REMARK 500    ASP O 165   CB  -  CG  -  OD1 ANGL. DEV. =  -5.5 DEGREES          
REMARK 500    ARG P 344   NE  -  CZ  -  NH1 ANGL. DEV. =   3.2 DEGREES          
REMARK 500    ARG P 344   NE  -  CZ  -  NH2 ANGL. DEV. =  -3.3 DEGREES          
REMARK 500    GLY R  45   N   -  CA  -  C   ANGL. DEV. = -15.1 DEGREES          
REMARK 500    ARG R 221   NH1 -  CZ  -  NH2 ANGL. DEV. =  25.1 DEGREES          
REMARK 500    ARG R 221   NE  -  CZ  -  NH1 ANGL. DEV. = -12.5 DEGREES          
REMARK 500    ARG R 221   NE  -  CZ  -  NH2 ANGL. DEV. = -12.6 DEGREES          
REMARK 500    SER R 226   CB  -  CA  -  C   ANGL. DEV. = -14.4 DEGREES          
REMARK 500    SER R 226   N   -  CA  -  CB  ANGL. DEV. =  16.8 DEGREES          
REMARK 500    VAL R 227   CB  -  CA  -  C   ANGL. DEV. = -28.8 DEGREES          
REMARK 500    VAL R 227   N   -  CA  -  CB  ANGL. DEV. =  29.9 DEGREES          
REMARK 500    ARG R 240   NH1 -  CZ  -  NH2 ANGL. DEV. =  25.1 DEGREES          
REMARK 500    ARG R 240   NE  -  CZ  -  NH1 ANGL. DEV. = -12.5 DEGREES          
REMARK 500    ARG R 240   NE  -  CZ  -  NH2 ANGL. DEV. = -12.6 DEGREES          
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     113 ANGLE DEVIATIONS.                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASN A  33      -24.35     81.69                                   
REMARK 500    GLN A  38       77.96   -106.05                                   
REMARK 500    GLU A  47      -55.82    -24.56                                   
REMARK 500    ALA A  55       57.61     39.25                                   
REMARK 500    LEU A  57     -123.01     64.44                                   
REMARK 500    GLU A  85       18.90     59.51                                   
REMARK 500    VAL A  87     -105.17     57.50                                   
REMARK 500    ASP A  88        3.98     58.08                                   
REMARK 500    ASP A 120      -33.50     79.19                                   
REMARK 500    GLN A 125      -61.53   -136.20                                   
REMARK 500    TYR A 185        1.86     85.30                                   
REMARK 500    VAL A 274      -36.29    127.51                                   
REMARK 500    LYS A 275     -138.97     67.09                                   
REMARK 500    LYS A 429      131.05   -172.48                                   
REMARK 500    ASP A 486       31.50     78.22                                   
REMARK 500    ASP A 589       58.82     38.90                                   
REMARK 500    ASN A 593      -24.81     94.61                                   
REMARK 500    ALA A 613      -76.55   -110.02                                   
REMARK 500    THR A 614      -27.92     85.21                                   
REMARK 500    PRO A 630     -115.29    -69.87                                   
REMARK 500    SER A 652     -107.28     61.42                                   
REMARK 500    TYR A 653      -31.10     91.30                                   
REMARK 500    MET A 668      -61.88   -101.96                                   
REMARK 500    THR A 777      -28.67     78.37                                   
REMARK 500    GLU A 781      -31.72     90.14                                   
REMARK 500    LYS A 798       17.51     80.72                                   
REMARK 500    LEU A 813       60.92     76.43                                   
REMARK 500    MET A 857      -83.40     81.81                                   
REMARK 500    TYR A 860      156.34    105.98                                   
REMARK 500    CYS A 867       38.19    -88.36                                   
REMARK 500    ARG A 980       66.99   -165.83                                   
REMARK 500    ASP A1014      -20.42     78.39                                   
REMARK 500    GLU A1030     -118.94     67.98                                   
REMARK 500    HIS A1045      167.77     75.51                                   
REMARK 500    PRO A1055       56.86    -54.68                                   
REMARK 500    GLU A1098      156.62    -44.59                                   
REMARK 500    PRO A1099      -72.58    -78.14                                   
REMARK 500    LEU A1100      -73.74   -141.37                                   
REMARK 500    ILE A1125      147.99     69.14                                   
REMARK 500    MET A1131      143.40    -38.53                                   
REMARK 500    THR A1132      -14.65     83.94                                   
REMARK 500    LYS A1164       -3.09     57.66                                   
REMARK 500    LEU A1217       64.25     30.89                                   
REMARK 500    MET A1220       61.49     70.99                                   
REMARK 500    THR A1239      172.24    178.55                                   
REMARK 500    GLU A1284     -132.44     46.49                                   
REMARK 500    TYR A1287        7.11     96.29                                   
REMARK 500    CYS A1288       50.66   -105.41                                   
REMARK 500    LEU A1307       76.72     15.46                                   
REMARK 500    ILE A1314     -106.42     45.41                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     373 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 MET A   11     ILE A   12                 -144.31                    
REMARK 500 ALA A   14     ARG A   15                 -149.26                    
REMARK 500 ILE A   83     GLY A   84                  139.31                    
REMARK 500 ASP A   86     VAL A   87                  148.63                    
REMARK 500 GLN A  124     GLN A  125                 -149.85                    
REMARK 500 GLU A  840     PRO A  841                 -149.36                    
REMARK 500 PRO A  859     TYR A  860                  141.42                    
REMARK 500 GLY A 1282     PRO A 1283                  148.86                    
REMARK 500 MET A 1652     ALA A 1653                 -147.39                    
REMARK 500 GLY I  658     ARG I  659                 -146.67                    
REMARK 500 PHE I  727     ARG I  728                  149.53                    
REMARK 500 ILE J  220     PRO J  221                 -124.20                    
REMARK 500 LEU N   62     ARG N   63                  134.97                    
REMARK 500 ARG N   63     GLY N   64                   31.42                    
REMARK 500 GLU N   77     VAL N   78                  128.10                    
REMARK 500 VAL N   78     LEU N   79                  144.08                    
REMARK 500 GLN N  147     GLY N  148                  149.68                    
REMARK 500 PHE N  162     PHE N  163                   44.66                    
REMARK 500 SER N  164     THR N  165                  -44.41                    
REMARK 500 GLY N  201     GLU N  202                 -130.53                    
REMARK 500 GLU N  280     TYR N  281                   49.79                    
REMARK 500 TYR N  281     GLU N  282                 -121.54                    
REMARK 500 GLU N  282     ARG N  283                  148.49                    
REMARK 500 LEU N  321     ARG N  322                  149.21                    
REMARK 500 PHE N  351     PRO N  352                  140.11                    
REMARK 500 PRO N  352     ASP N  353                 -135.67                    
REMARK 500 ASP N  353     SER N  354                 -142.50                    
REMARK 500 ARG N  367     THR N  368                 -136.92                    
REMARK 500 LEU N  387     HIS N  388                 -132.86                    
REMARK 500 CYS N  394     ASP N  395                   98.07                    
REMARK 500 ASP N  395     ILE N  396                  137.31                    
REMARK 500 PRO N  477     GLU N  478                  -33.21                    
REMARK 500 PRO N  482     ASP N  483                 -142.62                    
REMARK 500 PRO N  484     VAL N  485                   37.58                    
REMARK 500 VAL N  485     ASP N  486                  138.13                    
REMARK 500 ALA N  487     ASP N  488                  132.00                    
REMARK 500 LYS N  495     ARG N  496                  142.45                    
REMARK 500 TYR N  509     GLY N  510                  -37.36                    
REMARK 500 PHE R   48     ILE R   49                  132.89                    
REMARK 500 SER R  131     LEU R  132                   30.43                    
REMARK 500 PRO R  431     SER R  432                   42.66                    
REMARK 500 ALA T    3     ALA T    4                 -143.66                    
REMARK 500 ASN X  385     MET X  386                  148.65                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    GLN R 310        -46.95                                           
REMARK 500    PRO R 431        -66.66                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN B 101  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B  59   SG                                                     
REMARK 620 2 CYS B  23   SG  148.0                                              
REMARK 620 3 CYS B  26   SG   96.4 106.0                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN B 102  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B  76   SG                                                     
REMARK 620 2 CYS B  73   SG  107.1                                              
REMARK 620 3 HIS B  53   ND1 111.9 125.1                                        
REMARK 620 N                    1     2                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN B 101                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN B 102                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN B 103                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN S 601                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN S 602                  
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-2924   RELATED DB: EMDB                              
DBREF  4UI9 A    1  1947  UNP    Q9H1A4   APC1_HUMAN       1   1944             
DBREF  4UI9 B    1    84  UNP    Q9NYG5   APC11_HUMAN      1     84             
DBREF  4UI9 C    7   597  UNP    Q9UJX2   CDC23_HUMAN      7    597             
DBREF  4UI9 D    1   121  UNP    P60006   APC15_HUMAN      1    121             
DBREF  4UI9 E    1   110  UNP    Q96DE5   APC16_HUMAN      1    110             
DBREF  4UI9 F    1   861  UNP    P30260   CDC27_HUMAN      1    824             
DBREF  4UI9 G    1    85  UNP    Q8NHZ8   CDC26_HUMAN      1     85             
DBREF  4UI9 H    1   828  UNP    P30260   CDC27_HUMAN      1    824             
DBREF  4UI9 I    1   808  UNP    Q9UJX5   APC4_HUMAN       1    808             
DBREF  4UI9 J    1   620  UNP    Q13042   CDC16_HUMAN      1    620             
DBREF  4UI9 K    1   620  UNP    Q13042   CDC16_HUMAN      1    620             
DBREF  4UI9 L    2   184  UNP    Q9UM13   APC10_HUMAN      2    185             
DBREF  4UI9 M    1    74  UNP    Q9BS18   APC13_HUMAN      1     74             
DBREF  4UI9 N    1   822  UNP    Q9UJX6   ANC2_HUMAN       1    822             
DBREF  4UI9 O    1   755  UNP    Q9UJX4   APC5_HUMAN       1    755             
DBREF  4UI9 P    7   597  UNP    Q9UJX2   CDC23_HUMAN      7    597             
DBREF  4UI9 R    1   493  UNP    Q9UM11   FZR_HUMAN        1    493             
DBREF  4UI9 S    1   447  UNP    Q9UKT4   FBX5_HUMAN       1    447             
DBREF  4UI9 T    1    21  PDB    4UI9     4UI9             1     21             
DBREF  4UI9 U    5    28  PDB    4UI9     4UI9             5     28             
DBREF  4UI9 W    1    85  UNP    Q8NHZ8   CDC26_HUMAN      1     85             
DBREF  4UI9 X   35   599  UNP    Q9UJX3   APC7_HUMAN      35    599             
DBREF  4UI9 Y   35   599  UNP    Q9UJX3   APC7_HUMAN      35    599             
SEQADV 4UI9 PHE A  291  UNP  Q9H1A4    THR   291 CONFLICT                       
SEQADV 4UI9 ILE A  940  UNP  Q9H1A4    THR   940 CONFLICT                       
SEQADV 4UI9 GLU A 1059  UNP  Q9H1A4    ASP  1059 CONFLICT                       
SEQADV 4UI9 LEU A 1358  UNP  Q9H1A4    ILE  1358 CONFLICT                       
SEQADV 4UI9 LEU A 1637  UNP  Q9H1A4    THR  1637 CONFLICT                       
SEQADV 4UI9 PRO A 1880  UNP  Q9H1A4    LEU  1877 CONFLICT                       
SEQADV 4UI9 LEU A 1881  UNP  Q9H1A4    GLU  1878 CONFLICT                       
SEQADV 4UI9 LEU B   13  UNP  Q9NYG5    THR    13 CONFLICT                       
SEQADV 4UI9 LEU C  161  UNP  Q9UJX2    LYS   161 CONFLICT                       
SEQADV 4UI9 TYR D    5  UNP  P60006    PHE     5 CONFLICT                       
SEQADV 4UI9 GLU F  403  UNP  P30260    LYS   403 CONFLICT                       
SEQADV 4UI9 SER F  475  UNP  P30260    ALA   475 CONFLICT                       
SEQADV 4UI9 SER F  484  UNP  P30260    ALA   484 CONFLICT                       
SEQADV 4UI9 GLU G   14  UNP  Q8NHZ8    ASP    14 CONFLICT                       
SEQADV 4UI9 GLU H  403  UNP  P30260    LYS   403 CONFLICT                       
SEQADV 4UI9 SER H  475  UNP  P30260    ALA   475 CONFLICT                       
SEQADV 4UI9 SER H  484  UNP  P30260    ALA   484 CONFLICT                       
SEQADV 4UI9 ASP I  430  UNP  Q9UJX5    GLU   430 CONFLICT                       
SEQADV 4UI9 ASN J  225  UNP  Q13042    ASP   225 CONFLICT                       
SEQADV 4UI9 GLU J  228  UNP  Q13042    GLN   228 CONFLICT                       
SEQADV 4UI9 LYS J  229  UNP  Q13042    GLU   229 CONFLICT                       
SEQADV 4UI9 GLU K  228  UNP  Q13042    GLN   228 CONFLICT                       
SEQADV 4UI9 LYS K  229  UNP  Q13042    GLU   229 CONFLICT                       
SEQADV 4UI9 LYS K  265  UNP  Q13042    ALA   265 CONFLICT                       
SEQADV 4UI9     L       UNP  Q9UM13    GLU   163 DELETION                       
SEQADV 4UI9 ILE N  410  UNP  Q9UJX6    LEU   410 CONFLICT                       
SEQADV 4UI9 SER O   42  UNP  Q9UJX4    ASN    42 CONFLICT                       
SEQADV 4UI9 VAL O   55  UNP  Q9UJX4    MET    55 CONFLICT                       
SEQADV 4UI9 GLN O   63  UNP  Q9UJX4    LEU    63 CONFLICT                       
SEQADV 4UI9 VAL O   75  UNP  Q9UJX4    LEU    75 CONFLICT                       
SEQADV 4UI9 LEU O   79  UNP  Q9UJX4    TYR    79 CONFLICT                       
SEQADV 4UI9 SER O  164  UNP  Q9UJX4    ASN   164 CONFLICT                       
SEQADV 4UI9 ASP O  165  UNP  Q9UJX4    GLY   165 CONFLICT                       
SEQADV 4UI9 ASN O  167  UNP  Q9UJX4              INSERTION                      
SEQADV 4UI9 LEU P  161  UNP  Q9UJX2    LYS   161 CONFLICT                       
SEQADV 4UI9 ILE S  323  UNP  Q9UKT4    THR   323 CONFLICT                       
SEQADV 4UI9 LYS S  326  UNP  Q9UKT4    ALA   326 CONFLICT                       
SEQADV 4UI9 LEU X   63  UNP  Q9UJX3    MET    63 CONFLICT                       
SEQADV 4UI9 LEU X  142  UNP  Q9UJX3    MET   142 CONFLICT                       
SEQADV 4UI9 VAL X  148  UNP  Q9UJX3    MET   148 CONFLICT                       
SEQADV 4UI9 ASN X  466  UNP  Q9UJX3    ASP   466 CONFLICT                       
SEQADV 4UI9 GLU X  472  UNP  Q9UJX3    ARG   472 CONFLICT                       
SEQADV 4UI9 LEU Y   63  UNP  Q9UJX3    MET    63 CONFLICT                       
SEQADV 4UI9 LEU Y  142  UNP  Q9UJX3    MET   142 CONFLICT                       
SEQADV 4UI9 VAL Y  148  UNP  Q9UJX3    MET   148 CONFLICT                       
SEQADV 4UI9 ASN Y  466  UNP  Q9UJX3    ASP   466 CONFLICT                       
SEQADV 4UI9 GLU Y  472  UNP  Q9UJX3    ARG   472 CONFLICT                       
SEQRES   1 A 1944  MET SER ASN PHE TYR GLU GLU ARG THR THR MET ILE ALA          
SEQRES   2 A 1944  ALA ARG ASP LEU GLN GLU PHE VAL PRO PHE GLY ARG ASP          
SEQRES   3 A 1944  HIS CYS LYS HIS HIS PRO ASN ALA LEU ASN LEU GLN LEU          
SEQRES   4 A 1944  ARG GLN LEU GLN PRO ALA SER GLU LEU TRP SER SER ASP          
SEQRES   5 A 1944  GLY ALA ALA GLY LEU VAL GLY SER LEU GLN GLU VAL THR          
SEQRES   6 A 1944  ILE HIS GLU LYS GLN LYS GLU SER TRP GLN LEU ARG LYS          
SEQRES   7 A 1944  GLY VAL SER GLU ILE GLY GLU ASP VAL ASP TYR ASP GLU          
SEQRES   8 A 1944  GLU LEU TYR VAL ALA GLY ASN MET VAL ILE TRP SER LYS          
SEQRES   9 A 1944  GLY SER LYS SER GLN ALA LEU ALA VAL TYR LYS ALA PHE          
SEQRES  10 A 1944  THR VAL ASP SER PRO VAL GLN GLN ALA LEU TRP CYS ASP          
SEQRES  11 A 1944  PHE ILE ILE SER GLN ASP LYS SER GLU LYS ALA TYR SER          
SEQRES  12 A 1944  SER ASN GLU VAL GLU LYS CYS ILE CYS ILE LEU GLN SER          
SEQRES  13 A 1944  SER CYS ILE ASN MET HIS SER ILE GLU GLY LYS ASP TYR          
SEQRES  14 A 1944  ILE ALA SER LEU PRO PHE GLN VAL ALA ASN VAL TRP PRO          
SEQRES  15 A 1944  THR LYS TYR GLY LEU LEU PHE GLU ARG SER ALA SER SER          
SEQRES  16 A 1944  HIS GLU VAL PRO PRO GLY SER PRO ARG GLU PRO LEU PRO          
SEQRES  17 A 1944  THR MET PHE SER MET LEU HIS PRO LEU ASP GLU ILE THR          
SEQRES  18 A 1944  PRO LEU VAL CYS LYS SER GLY SER LEU PHE GLY SER SER          
SEQRES  19 A 1944  ARG VAL GLN TYR VAL VAL ASP HIS ALA MET LYS ILE VAL          
SEQRES  20 A 1944  PHE LEU ASN THR ASP PRO SER ILE VAL MET THR TYR ASP          
SEQRES  21 A 1944  ALA VAL GLN ASN VAL HIS SER VAL TRP THR LEU ARG ARG          
SEQRES  22 A 1944  VAL LYS SER GLU GLU GLU ASN VAL VAL LEU LYS PHE SER          
SEQRES  23 A 1944  GLU GLN GLY GLY PHE PRO GLN ASN VAL ALA THR SER SER          
SEQRES  24 A 1944  SER LEU THR ALA HIS LEU ARG SER LEU SER LYS GLY ASP          
SEQRES  25 A 1944  SER PRO VAL THR SER PRO PHE GLN ASN TYR SER SER ILE          
SEQRES  26 A 1944  HIS SER GLN SER ARG SER THR SER SER PRO SER LEU HIS          
SEQRES  27 A 1944  SER ARG SER PRO SER ILE SER ASN MET ALA ALA LEU SER          
SEQRES  28 A 1944  ARG ALA HIS SER PRO ALA LEU GLY VAL HIS SER PHE SER          
SEQRES  29 A 1944  GLY VAL GLN ARG PHE ASN ILE SER SER HIS ASN GLN SER          
SEQRES  30 A 1944  PRO LYS ARG HIS SER ILE SER HIS SER PRO ASN SER ASN          
SEQRES  31 A 1944  SER ASN GLY SER PHE LEU ALA PRO GLU THR GLU PRO ILE          
SEQRES  32 A 1944  VAL PRO GLU LEU CYS ILE ASP HIS LEU TRP THR GLU THR          
SEQRES  33 A 1944  ILE THR ASN ILE ARG GLU LYS ASN SER GLN ALA SER LYS          
SEQRES  34 A 1944  VAL PHE ILE THR SER ASP LEU CYS GLY GLN LYS PHE LEU          
SEQRES  35 A 1944  CYS PHE LEU VAL GLU SER GLN LEU GLN LEU ARG CYS VAL          
SEQRES  36 A 1944  LYS PHE GLN GLU SER ASN ASP LYS THR GLN LEU ILE PHE          
SEQRES  37 A 1944  GLY SER VAL THR ASN ILE PRO ALA LYS ASP ALA ALA PRO          
SEQRES  38 A 1944  VAL GLU LYS ILE ASP THR MET LEU VAL LEU GLU GLY SER          
SEQRES  39 A 1944  GLY ASN LEU VAL LEU TYR THR GLY VAL VAL ARG VAL GLY          
SEQRES  40 A 1944  LYS VAL PHE ILE PRO GLY LEU PRO ALA PRO SER LEU THR          
SEQRES  41 A 1944  MET SER ASN THR MET PRO ARG PRO SER THR PRO LEU ASP          
SEQRES  42 A 1944  GLY VAL SER THR PRO LYS PRO LEU SER LYS LEU LEU GLY          
SEQRES  43 A 1944  SER LEU ASP GLU VAL VAL LEU LEU SER PRO VAL PRO GLU          
SEQRES  44 A 1944  LEU ARG ASP SER SER LYS LEU HIS ASP SER LEU TYR ASN          
SEQRES  45 A 1944  GLU ASP CYS THR PHE GLN GLN LEU GLY THR TYR ILE HIS          
SEQRES  46 A 1944  SER ILE ARG ASP PRO VAL HIS ASN ARG VAL THR LEU GLU          
SEQRES  47 A 1944  LEU SER ASN GLY SER MET VAL ARG ILE THR ILE PRO GLU          
SEQRES  48 A 1944  ILE ALA THR SER GLU LEU VAL GLN THR CYS LEU GLN ALA          
SEQRES  49 A 1944  ILE LYS PHE ILE LEU PRO LYS GLU ILE ALA VAL GLN MET          
SEQRES  50 A 1944  LEU VAL LYS TRP TYR ASN VAL HIS SER ALA PRO GLY GLY          
SEQRES  51 A 1944  PRO SER TYR HIS SER GLU TRP ASN LEU PHE VAL THR CYS          
SEQRES  52 A 1944  LEU MET ASN MET MET GLY TYR ASN THR ASP ARG LEU ALA          
SEQRES  53 A 1944  TRP THR ARG ASN PHE ASP PHE GLU GLY SER LEU SER PRO          
SEQRES  54 A 1944  VAL ILE ALA PRO LYS LYS ALA ARG PRO SER GLU THR GLY          
SEQRES  55 A 1944  SER ASP ASP ASP TRP GLU TYR LEU LEU ASN SER ASP TYR          
SEQRES  56 A 1944  HIS GLN ASN VAL GLU SER HIS LEU LEU ASN ARG SER LEU          
SEQRES  57 A 1944  CYS LEU SER PRO SER GLU ALA SER GLN MET LYS ASP GLU          
SEQRES  58 A 1944  ASP PHE SER GLN ASN LEU SER LEU ASP SER SER THR LEU          
SEQRES  59 A 1944  LEU PHE THR HIS ILE PRO ALA ILE PHE PHE VAL LEU HIS          
SEQRES  60 A 1944  LEU VAL TYR GLU GLU LEU LYS LEU ASN THR LEU MET GLY          
SEQRES  61 A 1944  GLU GLY ILE CYS SER LEU VAL GLU LEU LEU VAL GLN LEU          
SEQRES  62 A 1944  ALA ARG ASP LEU LYS LEU GLY PRO TYR VAL ASP HIS TYR          
SEQRES  63 A 1944  TYR ARG ASP TYR PRO THR LEU VAL ARG THR THR GLY GLN          
SEQRES  64 A 1944  VAL CYS THR ILE ASP PRO GLY GLN THR GLY PHE MET HIS          
SEQRES  65 A 1944  HIS PRO SER PHE PHE THR SER GLU PRO PRO SER ILE TYR          
SEQRES  66 A 1944  GLN TRP VAL SER SER CYS LEU LYS GLY GLU GLY MET PRO          
SEQRES  67 A 1944  PRO TYR PRO TYR LEU PRO GLY ILE CYS GLU ARG SER ARG          
SEQRES  68 A 1944  LEU VAL VAL LEU SER ILE ALA LEU TYR ILE LEU GLY ASP          
SEQRES  69 A 1944  GLU SER LEU VAL SER ASP GLU SER SER GLN TYR LEU THR          
SEQRES  70 A 1944  ARG ILE THR ILE ALA PRO GLN LYS LEU GLN VAL GLU GLN          
SEQRES  71 A 1944  GLU GLU ASN ARG PHE SER PHE ARG HIS SER THR SER VAL          
SEQRES  72 A 1944  SER SER LEU ALA GLU ARG LEU VAL VAL TRP MET THR ASN          
SEQRES  73 A 1944  VAL GLY PHE ILE LEU ARG ASP LEU GLU THR LEU PRO PHE          
SEQRES  74 A 1944  GLY ILE ALA LEU PRO ILE ARG ASP ALA ILE TYR HIS CYS          
SEQRES  75 A 1944  ARG GLU GLN PRO ALA SER ASP TRP PRO GLU ALA VAL CYS          
SEQRES  76 A 1944  LEU LEU ILE GLY ARG GLN ASP LEU SER LYS GLN ALA CYS          
SEQRES  77 A 1944  GLU GLY ASN LEU PRO LYS GLY LYS SER VAL LEU SER SER          
SEQRES  78 A 1944  ASP VAL PRO SER GLY THR GLU THR GLU GLU GLU ASP ASP          
SEQRES  79 A 1944  GLY MET ASN ASP MET ASN HIS GLU VAL MET SER LEU ILE          
SEQRES  80 A 1944  TRP SER GLU ASP LEU ARG VAL GLN ASP VAL ARG ARG LEU          
SEQRES  81 A 1944  LEU GLN SER ALA HIS PRO VAL ARG VAL ASN VAL VAL GLN          
SEQRES  82 A 1944  TYR PRO GLU LEU SER GLU HIS GLU PHE ILE GLU GLU LYS          
SEQRES  83 A 1944  GLU ASN ARG LEU LEU GLN LEU CYS GLN ARG THR MET ALA          
SEQRES  84 A 1944  LEU PRO VAL GLY ARG GLY MET PHE THR LEU PHE SER TYR          
SEQRES  85 A 1944  HIS PRO VAL PRO THR GLU PRO LEU PRO ILE PRO LYS LEU          
SEQRES  86 A 1944  ASN LEU THR GLY ARG ALA PRO PRO ARG ASN THR THR VAL          
SEQRES  87 A 1944  ASP LEU ASN SER GLY ASN ILE ASP VAL PRO PRO ASN MET          
SEQRES  88 A 1944  THR SER TRP ALA SER PHE HIS ASN GLY VAL ALA ALA GLY          
SEQRES  89 A 1944  LEU LYS ILE ALA PRO ALA SER GLN ILE ASP SER ALA TRP          
SEQRES  90 A 1944  ILE VAL TYR ASN LYS PRO LYS HIS ALA GLU LEU ALA ASN          
SEQRES  91 A 1944  GLU TYR ALA GLY PHE LEU MET ALA LEU GLY LEU ASN GLY          
SEQRES  92 A 1944  HIS LEU THR LYS LEU ALA THR LEU ASN ILE HIS ASP TYR          
SEQRES  93 A 1944  LEU THR LYS GLY HIS GLU MET THR SER ILE GLY LEU LEU          
SEQRES  94 A 1944  LEU GLY VAL SER ALA ALA LYS LEU GLY THR MET ASP MET          
SEQRES  95 A 1944  SER ILE THR ARG LEU LEU SER ILE HIS ILE PRO ALA LEU          
SEQRES  96 A 1944  LEU PRO PRO THR SER THR GLU LEU ASP VAL PRO HIS ASN          
SEQRES  97 A 1944  VAL GLN VAL ALA ALA VAL VAL GLY ILE GLY LEU VAL TYR          
SEQRES  98 A 1944  GLN GLY THR ALA HIS ARG HIS THR ALA GLU VAL LEU LEU          
SEQRES  99 A 1944  ALA GLU ILE GLY ARG PRO PRO GLY PRO GLU MET GLU TYR          
SEQRES 100 A 1944  CYS THR ASP ARG GLU SER TYR SER LEU ALA ALA GLY LEU          
SEQRES 101 A 1944  ALA LEU GLY MET VAL CYS LEU GLY HIS GLY SER ASN LEU          
SEQRES 102 A 1944  ILE GLY MET SER ASP LEU ASN VAL PRO GLU GLN LEU TYR          
SEQRES 103 A 1944  GLN TYR MET VAL GLY GLY HIS ARG ARG PHE GLN THR GLY          
SEQRES 104 A 1944  MET HIS ARG GLU LYS HIS LYS SER PRO SER TYR GLN ILE          
SEQRES 105 A 1944  LYS GLU GLY ASP THR LEU ASN VAL ASP VAL THR CYS PRO          
SEQRES 106 A 1944  GLY ALA THR LEU ALA LEU ALA MET ILE TYR LEU LYS THR          
SEQRES 107 A 1944  ASN ASN ARG SER ILE ALA ASP TRP LEU ARG ALA PRO ASP          
SEQRES 108 A 1944  THR MET TYR LEU LEU ASP PHE VAL LYS PRO GLU PHE LEU          
SEQRES 109 A 1944  LEU LEU ARG THR LEU ALA ARG CYS LEU ILE LEU TRP ASP          
SEQRES 110 A 1944  ASP ILE LEU PRO ASN SER LYS TRP VAL ASP SER ASN VAL          
SEQRES 111 A 1944  PRO GLN ILE ILE ARG GLU ASN SER ILE SER LEU SER GLU          
SEQRES 112 A 1944  ILE GLU LEU PRO CYS SER GLU ASP LEU ASN LEU GLU THR          
SEQRES 113 A 1944  LEU SER GLN ALA HIS VAL TYR ILE ILE ALA GLY ALA CYS          
SEQRES 114 A 1944  LEU SER LEU GLY PHE ARG PHE ALA GLY SER GLU ASN LEU          
SEQRES 115 A 1944  SER ALA PHE ASN CYS LEU HIS LYS PHE ALA LYS ASP PHE          
SEQRES 116 A 1944  MET THR TYR LEU SER ALA PRO ASN ALA SER VAL THR GLY          
SEQRES 117 A 1944  PRO HIS ASN LEU GLU THR CYS LEU SER VAL VAL LEU LEU          
SEQRES 118 A 1944  SER LEU ALA MET VAL MET ALA GLY SER GLY ASN LEU LYS          
SEQRES 119 A 1944  VAL LEU GLN LEU CYS ARG PHE LEU HIS MET LYS THR GLY          
SEQRES 120 A 1944  GLY GLU MET ASN TYR GLY PHE HIS LEU ALA HIS HIS MET          
SEQRES 121 A 1944  ALA LEU GLY LEU LEU PHE LEU GLY GLY GLY ARG TYR SER          
SEQRES 122 A 1944  LEU SER THR SER ASN SER SER ILE ALA ALA LEU LEU CYS          
SEQRES 123 A 1944  ALA LEU TYR PRO HIS PHE PRO ALA HIS SER THR ASP ASN          
SEQRES 124 A 1944  ARG TYR HIS LEU GLN ALA LEU ARG HIS LEU TYR VAL LEU          
SEQRES 125 A 1944  ALA ALA GLU PRO ARG LEU LEU VAL PRO VAL ASP VAL ASP          
SEQRES 126 A 1944  THR ASN THR PRO CYS TYR ALA LEU LEU GLU VAL LEU TYR          
SEQRES 127 A 1944  LYS GLY THR GLN TRP TYR GLU GLN THR LYS GLU GLU LEU          
SEQRES 128 A 1944  MET ALA PRO THR LEU LEU PRO GLU LEU HIS LEU LEU LYS          
SEQRES 129 A 1944  GLN ILE LYS VAL LYS GLY PRO ARG TYR TRP GLU LEU LEU          
SEQRES 130 A 1944  ILE ASP LEU SER LYS GLY THR GLN HIS LEU LYS SER ILE          
SEQRES 131 A 1944  LEU SER LYS ASP GLY VAL LEU TYR VAL LYS LEU ARG ALA          
SEQRES 132 A 1944  GLY GLN LEU SER TYR LYS GLU ASP PRO MET GLY TRP GLN          
SEQRES 133 A 1944  SER LEU LEU ALA GLN THR VAL ALA ASN ARG ASN SER GLU          
SEQRES 134 A 1944  ALA ARG ALA PHE LYS PRO GLU THR ILE SER ALA PHE THR          
SEQRES 135 A 1944  SER ASP PRO ALA LEU LEU SER PHE ALA GLU TYR PHE CYS          
SEQRES 136 A 1944  LYS PRO THR VAL ASN MET GLY GLN LYS GLN GLU ILE LEU          
SEQRES 137 A 1944  ASP LEU PHE SER SER VAL LEU TYR GLU CYS VAL THR GLN          
SEQRES 138 A 1944  GLU THR PRO GLU MET LEU PRO ALA TYR ILE ALA MET ASP          
SEQRES 139 A 1944  GLN ALA ILE ARG ARG LEU GLY ARG ARG GLU MET SER GLU          
SEQRES 140 A 1944  THR SER GLU LEU TRP GLN ILE LYS LEU VAL LEU GLU PHE          
SEQRES 141 A 1944  PHE SER SER ARG SER HIS GLN GLU ARG LEU GLN ASN HIS          
SEQRES 142 A 1944  PRO LYS ARG GLY LEU PHE MET ASN SER GLU PHE LEU PRO          
SEQRES 143 A 1944  VAL VAL LYS CYS THR ILE ASP ASN THR LEU ASP GLN TRP          
SEQRES 144 A 1944  LEU GLN VAL GLY GLY ASP MET CYS VAL HIS ALA TYR LEU          
SEQRES 145 A 1944  SER GLY GLN PRO PRO LEU GLU SER GLN LEU SER MET LEU          
SEQRES 146 A 1944  ALA CYS PHE LEU VAL TYR HIS SER VAL PRO ALA PRO GLN          
SEQRES 147 A 1944  HIS LEU PRO PRO ILE GLY LEU GLU GLY SER THR SER PHE          
SEQRES 148 A 1944  ALA GLU LEU LEU PHE LYS PHE LYS GLN LEU LYS MET PRO          
SEQRES 149 A 1944  VAL ARG ALA LEU LEU ARG LEU ALA PRO LEU LEU LEU GLY          
SEQRES 150 A 1944  ASN PRO GLN PRO MET VAL MET                                  
SEQRES   1 B   84  MET LYS VAL LYS ILE LYS CYS TRP ASN GLY VAL ALA LEU          
SEQRES   2 B   84  TRP LEU TRP VAL ALA ASN ASP GLU ASN CYS GLY ILE CYS          
SEQRES   3 B   84  ARG MET ALA PHE ASN GLY CYS CYS PRO ASP CYS LYS VAL          
SEQRES   4 B   84  PRO GLY ASP ASP CYS PRO LEU VAL TRP GLY GLN CYS SER          
SEQRES   5 B   84  HIS CYS PHE HIS MET HIS CYS ILE LEU LYS TRP LEU HIS          
SEQRES   6 B   84  ALA GLN GLN VAL GLN GLN HIS CYS PRO MET CYS ARG GLN          
SEQRES   7 B   84  GLU TRP LYS PHE LYS GLU                                      
SEQRES   1 C  591  MET VAL PRO VAL ALA VAL THR ALA ALA VAL ALA PRO VAL          
SEQRES   2 C  591  LEU SER ILE ASN SER ASP PHE SER ASP LEU ARG GLU ILE          
SEQRES   3 C  591  LYS LYS GLN LEU LEU LEU ILE ALA GLY LEU THR ARG GLU          
SEQRES   4 C  591  ARG GLY LEU LEU HIS SER SER LYS TRP SER ALA GLU LEU          
SEQRES   5 C  591  ALA PHE SER LEU PRO ALA LEU PRO LEU ALA GLU LEU GLN          
SEQRES   6 C  591  PRO PRO PRO PRO ILE THR GLU GLU ASP ALA GLN ASP MET          
SEQRES   7 C  591  ASP ALA TYR THR LEU ALA LYS ALA TYR PHE ASP VAL LYS          
SEQRES   8 C  591  GLU TYR ASP ARG ALA ALA HIS PHE LEU HIS GLY CYS ASN          
SEQRES   9 C  591  SER LYS LYS ALA TYR PHE LEU TYR MET TYR SER ARG TYR          
SEQRES  10 C  591  LEU SER GLY GLU LYS LYS LYS ASP ASP GLU THR VAL ASP          
SEQRES  11 C  591  SER LEU GLY PRO LEU GLU LYS GLY GLN VAL LYS ASN GLU          
SEQRES  12 C  591  ALA LEU ARG GLU LEU ARG VAL GLU LEU SER LYS LEU HIS          
SEQRES  13 C  591  GLN ALA ARG GLU LEU ASP GLY PHE GLY LEU TYR LEU TYR          
SEQRES  14 C  591  GLY VAL VAL LEU ARG LYS LEU ASP LEU VAL LYS GLU ALA          
SEQRES  15 C  591  ILE ASP VAL PHE VAL GLU ALA THR HIS VAL LEU PRO LEU          
SEQRES  16 C  591  HIS TRP GLY ALA TRP LEU GLU LEU CYS ASN LEU ILE THR          
SEQRES  17 C  591  ASP LYS GLU MET LEU LYS PHE LEU SER LEU PRO ASP THR          
SEQRES  18 C  591  TRP MET LYS GLU PHE PHE LEU ALA HIS ILE TYR THR GLU          
SEQRES  19 C  591  LEU GLN LEU ILE GLU GLU ALA LEU GLN LYS TYR GLN ASN          
SEQRES  20 C  591  LEU ILE ASP VAL GLY PHE SER LYS SER SER TYR ILE VAL          
SEQRES  21 C  591  SER GLN ILE ALA VAL ALA TYR HIS ASN ILE ARG ASP ILE          
SEQRES  22 C  591  ASP LYS ALA LEU SER ILE PHE ASN GLU LEU ARG LYS GLN          
SEQRES  23 C  591  ASP PRO TYR ARG ILE GLU ASN MET ASP THR PHE SER ASN          
SEQRES  24 C  591  LEU LEU TYR VAL ARG SER MET LYS SER GLU LEU SER TYR          
SEQRES  25 C  591  LEU ALA HIS ASN LEU CYS GLU ILE ASP LYS TYR ARG VAL          
SEQRES  26 C  591  GLU THR CYS CYS VAL ILE GLY ASN TYR TYR SER LEU ARG          
SEQRES  27 C  591  SER GLN HIS GLU LYS ALA ALA LEU TYR PHE GLN ARG ALA          
SEQRES  28 C  591  LEU LYS LEU ASN PRO ARG TYR LEU GLY ALA TRP THR LEU          
SEQRES  29 C  591  MET GLY HIS GLU TYR MET GLU MET LYS ASN THR SER ALA          
SEQRES  30 C  591  ALA ILE GLN ALA TYR ARG HIS ALA ILE GLU VAL ASN LYS          
SEQRES  31 C  591  ARG ASP TYR ARG ALA TRP TYR GLY LEU GLY GLN THR TYR          
SEQRES  32 C  591  GLU ILE LEU LYS MET PRO PHE TYR CYS LEU TYR TYR TYR          
SEQRES  33 C  591  ARG ARG ALA HIS GLN LEU ARG PRO ASN ASP SER ARG MET          
SEQRES  34 C  591  LEU VAL ALA LEU GLY GLU CYS TYR GLU LYS LEU ASN GLN          
SEQRES  35 C  591  LEU VAL GLU ALA LYS LYS CYS TYR TRP ARG ALA TYR ALA          
SEQRES  36 C  591  VAL GLY ASP VAL GLU LYS MET ALA LEU VAL LYS LEU ALA          
SEQRES  37 C  591  LYS LEU HIS GLU GLN LEU THR GLU SER GLU GLN ALA ALA          
SEQRES  38 C  591  GLN CYS TYR ILE LYS TYR ILE GLN ASP ILE TYR SER CYS          
SEQRES  39 C  591  GLY GLU ILE VAL GLU HIS LEU GLU GLU SER THR ALA PHE          
SEQRES  40 C  591  ARG TYR LEU ALA GLN TYR TYR PHE LYS CYS LYS LEU TRP          
SEQRES  41 C  591  ASP GLU ALA SER THR CYS ALA GLN LYS CYS CYS ALA PHE          
SEQRES  42 C  591  ASN ASP THR ARG GLU GLU GLY LYS ALA LEU LEU ARG GLN          
SEQRES  43 C  591  ILE LEU GLN LEU ARG ASN GLN GLY GLU THR PRO THR THR          
SEQRES  44 C  591  GLU VAL PRO ALA PRO PHE PHE LEU PRO ALA SER LEU SER          
SEQRES  45 C  591  ALA ASN ASN THR PRO THR ARG ARG VAL SER PRO LEU ASN          
SEQRES  46 C  591  LEU SER SER VAL THR PRO                                      
SEQRES   1 D  121  MET SER THR LEU TYR PRO SER LEU PHE PRO ARG VAL THR          
SEQRES   2 D  121  GLU THR LEU TRP PHE ASN LEU ASP ARG PRO CYS VAL GLU          
SEQRES   3 D  121  GLU THR GLU LEU GLN GLN GLN GLU GLN GLN HIS GLN ALA          
SEQRES   4 D  121  TRP LEU GLN SER ILE ALA GLU LYS ASP ASN ASN LEU VAL          
SEQRES   5 D  121  PRO ILE GLY LYS PRO ALA SER GLU HIS TYR ASP ASP GLU          
SEQRES   6 D  121  GLU GLU GLU ASP ASP GLU ASP ASP GLU ASP SER GLU GLU          
SEQRES   7 D  121  ASP SER GLU ASP ASP GLU ASP MET GLN ASP MET ASP GLU          
SEQRES   8 D  121  MET ASN ASP TYR ASN GLU SER PRO ASP ASP GLY GLU VAL          
SEQRES   9 D  121  ASN GLU VAL ASP MET GLU GLY ASN GLU GLN ASP GLN ASP          
SEQRES  10 D  121  GLN TRP MET ILE                                              
SEQRES   1 E  110  MET ALA ALA SER SER SER SER SER SER ALA GLY GLY VAL          
SEQRES   2 E  110  SER GLY SER SER VAL THR GLY SER GLY PHE SER VAL SER          
SEQRES   3 E  110  ASP LEU ALA PRO PRO ARG LYS ALA LEU PHE THR TYR PRO          
SEQRES   4 E  110  LYS GLY ALA GLY GLU MET LEU GLU ASP GLY SER GLU ARG          
SEQRES   5 E  110  PHE LEU CYS GLU SER VAL PHE SER TYR GLN VAL ALA SER          
SEQRES   6 E  110  THR LEU LYS GLN VAL LYS HIS ASP GLN GLN VAL ALA ARG          
SEQRES   7 E  110  MET GLU LYS LEU ALA GLY LEU VAL GLU GLU LEU GLU ALA          
SEQRES   8 E  110  ASP GLU TRP ARG PHE LYS PRO ILE GLU GLN LEU LEU GLY          
SEQRES   9 E  110  PHE THR PRO SER SER GLY                                      
SEQRES   1 F  824  MET THR VAL LEU GLN GLU PRO VAL GLN ALA ALA ILE TRP          
SEQRES   2 F  824  GLN ALA LEU ASN HIS TYR ALA TYR ARG ASP ALA VAL PHE          
SEQRES   3 F  824  LEU ALA GLU ARG LEU TYR ALA GLU VAL HIS SER GLU GLU          
SEQRES   4 F  824  ALA LEU PHE LEU LEU ALA THR CYS TYR TYR ARG SER GLY          
SEQRES   5 F  824  LYS ALA TYR LYS ALA TYR ARG LEU LEU LYS GLY HIS SER          
SEQRES   6 F  824  CYS THR THR PRO GLN CYS LYS TYR LEU LEU ALA LYS CYS          
SEQRES   7 F  824  CYS VAL ASP LEU SER LYS LEU ALA GLU GLY GLU GLN ILE          
SEQRES   8 F  824  LEU SER GLY GLY VAL PHE ASN LYS GLN LYS SER HIS ASP          
SEQRES   9 F  824  ASP ILE VAL THR GLU PHE GLY ASP SER ALA CYS PHE THR          
SEQRES  10 F  824  LEU SER LEU LEU GLY HIS VAL TYR CYS LYS THR ASP ARG          
SEQRES  11 F  824  LEU ALA LYS GLY SER GLU CYS TYR GLN LYS SER LEU SER          
SEQRES  12 F  824  LEU ASN PRO PHE LEU TRP SER PRO PHE GLU SER LEU CYS          
SEQRES  13 F  824  GLU ILE GLY GLU LYS PRO ASP PRO ASP GLN THR PHE LYS          
SEQRES  14 F  824  PHE THR SER LEU GLN ASN PHE SER ASN CYS LEU PRO ASN          
SEQRES  15 F  824  SER CYS THR THR GLN VAL PRO ASN HIS SER LEU SER HIS          
SEQRES  16 F  824  ARG GLN PRO GLU THR VAL LEU THR GLU THR PRO GLN ASP          
SEQRES  17 F  824  THR ILE GLU LEU ASN ARG LEU ASN LEU GLU SER SER ASN          
SEQRES  18 F  824  SER LYS TYR SER LEU ASN THR ASP SER SER VAL SER TYR          
SEQRES  19 F  824  ILE ASP SER ALA VAL ILE SER PRO ASP THR VAL PRO LEU          
SEQRES  20 F  824  GLY THR GLY THR SER ILE LEU SER LYS GLN VAL GLN ASN          
SEQRES  21 F  824  LYS PRO LYS THR GLY ARG SER LEU LEU GLY GLY PRO ALA          
SEQRES  22 F  824  ALA LEU SER PRO LEU THR PRO SER PHE GLY ILE LEU PRO          
SEQRES  23 F  824  LEU GLU THR PRO SER PRO GLY ASP GLY SER TYR LEU GLN          
SEQRES  24 F  824  ASN TYR THR ASN THR PRO PRO VAL ILE ASP VAL PRO SER          
SEQRES  25 F  824  THR GLY ALA PRO SER LYS LYS SER VAL ALA ARG ILE GLY          
SEQRES  26 F  824  GLN THR GLY THR LYS SER VAL PHE SER GLN SER GLY ASN          
SEQRES  27 F  824  SER ARG GLU VAL THR PRO ILE LEU ALA GLN THR GLN SER          
SEQRES  28 F  824  SER GLY PRO GLN THR SER THR THR PRO GLN VAL LEU SER          
SEQRES  29 F  824  PRO THR ILE THR SER PRO PRO ASN ALA LEU PRO ARG ARG          
SEQRES  30 F  824  SER SER ARG LEU PHE THR SER ASP SER SER THR THR LYS          
SEQRES  31 F  824  GLU ASN SER LYS LYS LEU LYS MET LYS PHE PRO PRO GLU          
SEQRES  32 F  824  ILE PRO ASN ARG LYS THR LYS SER LYS THR ASN LYS GLY          
SEQRES  33 F  824  GLY ILE THR GLN PRO ASN ILE ASN ASP SER LEU GLU ILE          
SEQRES  34 F  824  THR LYS LEU ASP SER SER ILE ILE SER GLU GLY LYS ILE          
SEQRES  35 F  824  SER THR ILE THR PRO GLN ILE GLN ALA PHE ASN LEU GLN          
SEQRES  36 F  824  LYS ALA ALA ALA GLU GLY LEU MET SER LEU LEU ARG GLU          
SEQRES  37 F  824  MET GLY LYS GLY TYR LEU SER LEU CYS SER TYR ASN CYS          
SEQRES  38 F  824  LYS GLU SER ILE ASN ILE LEU SER HIS LEU PRO SER HIS          
SEQRES  39 F  824  HIS TYR ASN THR GLY TRP VAL LEU CYS GLN ILE GLY ARG          
SEQRES  40 F  824  ALA TYR PHE GLU LEU SER GLU TYR MET GLN ALA GLU ARG          
SEQRES  41 F  824  ILE PHE SER GLU VAL ARG ARG ILE GLU ASN TYR ARG VAL          
SEQRES  42 F  824  GLU GLY MET GLU ILE TYR SER THR THR LEU TRP HIS LEU          
SEQRES  43 F  824  GLN LYS ASP VAL ALA LEU SER VAL LEU SER LYS ASP LEU          
SEQRES  44 F  824  THR ASP MET ASP LYS ASN SER PRO GLU ALA TRP CYS ALA          
SEQRES  45 F  824  ALA GLY ASN CYS PHE SER LEU GLN ARG GLU HIS ASP ILE          
SEQRES  46 F  824  ALA ILE LYS PHE PHE GLN ARG ALA ILE GLN VAL ASP PRO          
SEQRES  47 F  824  ASN TYR ALA TYR ALA TYR THR LEU LEU GLY HIS GLU PHE          
SEQRES  48 F  824  VAL LEU THR GLU GLU LEU ASP LYS ALA LEU ALA CYS PHE          
SEQRES  49 F  824  ARG ASN ALA ILE ARG VAL ASN PRO ARG HIS TYR ASN ALA          
SEQRES  50 F  824  TRP TYR GLY LEU GLY MET ILE TYR TYR LYS GLN GLU LYS          
SEQRES  51 F  824  PHE SER LEU ALA GLU MET HIS PHE GLN LYS ALA LEU ASP          
SEQRES  52 F  824  ILE ASN PRO GLN SER SER VAL LEU LEU CYS HIS ILE GLY          
SEQRES  53 F  824  VAL VAL GLN HIS ALA LEU LYS LYS SER GLU LYS ALA LEU          
SEQRES  54 F  824  ASP THR LEU ASN LYS ALA ILE VAL ILE ASP PRO LYS ASN          
SEQRES  55 F  824  PRO LEU CYS LYS PHE HIS ARG ALA SER VAL LEU PHE ALA          
SEQRES  56 F  824  ASN GLU LYS TYR LYS SER ALA LEU GLN GLU LEU GLU GLU          
SEQRES  57 F  824  LEU LYS GLN ILE VAL PRO LYS GLU SER LEU VAL TYR PHE          
SEQRES  58 F  824  LEU ILE GLY LYS VAL TYR LYS LYS LEU GLY GLN THR HIS          
SEQRES  59 F  824  LEU ALA LEU MET ASN PHE SER TRP ALA MET ASP LEU ASP          
SEQRES  60 F  824  PRO LYS GLY ALA ASN ASN GLN ILE LYS GLU ALA ILE ASP          
SEQRES  61 F  824  LYS ARG TYR LEU PRO ASP ASP GLU GLU PRO ILE THR GLN          
SEQRES  62 F  824  GLU GLU GLN ILE MET GLY THR ASP GLU SER GLN GLU SER          
SEQRES  63 F  824  SER MET THR ASP ALA ASP ASP THR GLN LEU HIS ALA ALA          
SEQRES  64 F  824  GLU SER ASP GLU PHE                                          
SEQRES   1 G   85  MET LEU ARG ARG LYS PRO THR ARG LEU GLU LEU LYS LEU          
SEQRES   2 G   85  GLU ASP ILE GLU GLU PHE GLU ASN ILE ARG LYS ASP LEU          
SEQRES   3 G   85  GLU THR ARG LYS LYS GLN LYS GLU ASP VAL GLU VAL VAL          
SEQRES   4 G   85  GLY GLY SER ASP GLY GLU GLY ALA ILE GLY LEU SER SER          
SEQRES   5 G   85  ASP PRO LYS SER ARG GLU GLN MET ILE ASN ASP ARG ILE          
SEQRES   6 G   85  GLY TYR LYS PRO GLN PRO LYS PRO ASN ASN ARG SER SER          
SEQRES   7 G   85  GLN PHE GLY SER LEU GLU PHE                                  
SEQRES   1 H  824  MET THR VAL LEU GLN GLU PRO VAL GLN ALA ALA ILE TRP          
SEQRES   2 H  824  GLN ALA LEU ASN HIS TYR ALA TYR ARG ASP ALA VAL PHE          
SEQRES   3 H  824  LEU ALA GLU ARG LEU TYR ALA GLU VAL HIS SER GLU GLU          
SEQRES   4 H  824  ALA LEU PHE LEU LEU ALA THR CYS TYR TYR ARG SER GLY          
SEQRES   5 H  824  LYS ALA TYR LYS ALA TYR ARG LEU LEU LYS GLY HIS SER          
SEQRES   6 H  824  CYS THR THR PRO GLN CYS LYS TYR LEU LEU ALA LYS CYS          
SEQRES   7 H  824  CYS VAL ASP LEU SER LYS LEU ALA GLU GLY GLU GLN ILE          
SEQRES   8 H  824  LEU SER GLY GLY VAL PHE ASN LYS GLN LYS SER HIS ASP          
SEQRES   9 H  824  ASP ILE VAL THR GLU PHE GLY ASP SER ALA CYS PHE THR          
SEQRES  10 H  824  LEU SER LEU LEU GLY HIS VAL TYR CYS LYS THR ASP ARG          
SEQRES  11 H  824  LEU ALA LYS GLY SER GLU CYS TYR GLN LYS SER LEU SER          
SEQRES  12 H  824  LEU ASN PRO PHE LEU TRP SER PRO PHE GLU SER LEU CYS          
SEQRES  13 H  824  GLU ILE GLY GLU LYS PRO ASP PRO ASP GLN THR PHE LYS          
SEQRES  14 H  824  PHE THR SER LEU GLN ASN PHE SER ASN CYS LEU PRO ASN          
SEQRES  15 H  824  SER CYS THR THR GLN VAL PRO ASN HIS SER LEU SER HIS          
SEQRES  16 H  824  ARG GLN PRO GLU THR VAL LEU THR GLU THR PRO GLN ASP          
SEQRES  17 H  824  THR ILE GLU LEU ASN ARG LEU ASN LEU GLU SER SER ASN          
SEQRES  18 H  824  SER LYS TYR SER LEU ASN THR ASP SER SER VAL SER TYR          
SEQRES  19 H  824  ILE ASP SER ALA VAL ILE SER PRO ASP THR VAL PRO LEU          
SEQRES  20 H  824  GLY THR GLY THR SER ILE LEU SER LYS GLN VAL GLN ASN          
SEQRES  21 H  824  LYS PRO LYS THR GLY ARG SER LEU LEU GLY GLY PRO ALA          
SEQRES  22 H  824  ALA LEU SER PRO LEU THR PRO SER PHE GLY ILE LEU PRO          
SEQRES  23 H  824  LEU GLU THR PRO SER PRO GLY ASP GLY SER TYR LEU GLN          
SEQRES  24 H  824  ASN TYR THR ASN THR PRO PRO VAL ILE ASP VAL PRO SER          
SEQRES  25 H  824  THR GLY ALA PRO SER LYS LYS SER VAL ALA ARG ILE GLY          
SEQRES  26 H  824  GLN THR GLY THR LYS SER VAL PHE SER GLN SER GLY ASN          
SEQRES  27 H  824  SER ARG GLU VAL THR PRO ILE LEU ALA GLN THR GLN SER          
SEQRES  28 H  824  SER GLY PRO GLN THR SER THR THR PRO GLN VAL LEU SER          
SEQRES  29 H  824  PRO THR ILE THR SER PRO PRO ASN ALA LEU PRO ARG ARG          
SEQRES  30 H  824  SER SER ARG LEU PHE THR SER ASP SER SER THR THR LYS          
SEQRES  31 H  824  GLU ASN SER LYS LYS LEU LYS MET LYS PHE PRO PRO GLU          
SEQRES  32 H  824  ILE PRO ASN ARG LYS THR LYS SER LYS THR ASN LYS GLY          
SEQRES  33 H  824  GLY ILE THR GLN PRO ASN ILE ASN ASP SER LEU GLU ILE          
SEQRES  34 H  824  THR LYS LEU ASP SER SER ILE ILE SER GLU GLY LYS ILE          
SEQRES  35 H  824  SER THR ILE THR PRO GLN ILE GLN ALA PHE ASN LEU GLN          
SEQRES  36 H  824  LYS ALA ALA ALA GLU GLY LEU MET SER LEU LEU ARG GLU          
SEQRES  37 H  824  MET GLY LYS GLY TYR LEU SER LEU CYS SER TYR ASN CYS          
SEQRES  38 H  824  LYS GLU SER ILE ASN ILE LEU SER HIS LEU PRO SER HIS          
SEQRES  39 H  824  HIS TYR ASN THR GLY TRP VAL LEU CYS GLN ILE GLY ARG          
SEQRES  40 H  824  ALA TYR PHE GLU LEU SER GLU TYR MET GLN ALA GLU ARG          
SEQRES  41 H  824  ILE PHE SER GLU VAL ARG ARG ILE GLU ASN TYR ARG VAL          
SEQRES  42 H  824  GLU GLY MET GLU ILE TYR SER THR THR LEU TRP HIS LEU          
SEQRES  43 H  824  GLN LYS ASP VAL ALA LEU SER VAL LEU SER LYS ASP LEU          
SEQRES  44 H  824  THR ASP MET ASP LYS ASN SER PRO GLU ALA TRP CYS ALA          
SEQRES  45 H  824  ALA GLY ASN CYS PHE SER LEU GLN ARG GLU HIS ASP ILE          
SEQRES  46 H  824  ALA ILE LYS PHE PHE GLN ARG ALA ILE GLN VAL ASP PRO          
SEQRES  47 H  824  ASN TYR ALA TYR ALA TYR THR LEU LEU GLY HIS GLU PHE          
SEQRES  48 H  824  VAL LEU THR GLU GLU LEU ASP LYS ALA LEU ALA CYS PHE          
SEQRES  49 H  824  ARG ASN ALA ILE ARG VAL ASN PRO ARG HIS TYR ASN ALA          
SEQRES  50 H  824  TRP TYR GLY LEU GLY MET ILE TYR TYR LYS GLN GLU LYS          
SEQRES  51 H  824  PHE SER LEU ALA GLU MET HIS PHE GLN LYS ALA LEU ASP          
SEQRES  52 H  824  ILE ASN PRO GLN SER SER VAL LEU LEU CYS HIS ILE GLY          
SEQRES  53 H  824  VAL VAL GLN HIS ALA LEU LYS LYS SER GLU LYS ALA LEU          
SEQRES  54 H  824  ASP THR LEU ASN LYS ALA ILE VAL ILE ASP PRO LYS ASN          
SEQRES  55 H  824  PRO LEU CYS LYS PHE HIS ARG ALA SER VAL LEU PHE ALA          
SEQRES  56 H  824  ASN GLU LYS TYR LYS SER ALA LEU GLN GLU LEU GLU GLU          
SEQRES  57 H  824  LEU LYS GLN ILE VAL PRO LYS GLU SER LEU VAL TYR PHE          
SEQRES  58 H  824  LEU ILE GLY LYS VAL TYR LYS LYS LEU GLY GLN THR HIS          
SEQRES  59 H  824  LEU ALA LEU MET ASN PHE SER TRP ALA MET ASP LEU ASP          
SEQRES  60 H  824  PRO LYS GLY ALA ASN ASN GLN ILE LYS GLU ALA ILE ASP          
SEQRES  61 H  824  LYS ARG TYR LEU PRO ASP ASP GLU GLU PRO ILE THR GLN          
SEQRES  62 H  824  GLU GLU GLN ILE MET GLY THR ASP GLU SER GLN GLU SER          
SEQRES  63 H  824  SER MET THR ASP ALA ASP ASP THR GLN LEU HIS ALA ALA          
SEQRES  64 H  824  GLU SER ASP GLU PHE                                          
SEQRES   1 I  808  MET LEU ARG PHE PRO THR CYS PHE PRO SER PHE ARG VAL          
SEQRES   2 I  808  VAL GLY GLU LYS GLN LEU PRO GLN GLU ILE ILE PHE LEU          
SEQRES   3 I  808  VAL TRP SER PRO LYS ARG ASP LEU ILE ALA LEU ALA ASN          
SEQRES   4 I  808  THR ALA GLY GLU VAL LEU LEU HIS ARG LEU ALA SER PHE          
SEQRES   5 I  808  HIS ARG VAL TRP SER PHE PRO PRO ASN GLU ASN THR GLY          
SEQRES   6 I  808  LYS GLU VAL THR CYS LEU ALA TRP ARG PRO ASP GLY LYS          
SEQRES   7 I  808  LEU LEU ALA PHE ALA LEU ALA ASP THR LYS LYS ILE VAL          
SEQRES   8 I  808  LEU CYS ASP VAL GLU LYS PRO GLU SER LEU HIS SER PHE          
SEQRES   9 I  808  SER VAL GLU ALA PRO VAL SER CYS MET HIS TRP MET GLU          
SEQRES  10 I  808  VAL THR VAL GLU SER SER VAL LEU THR SER PHE TYR ASN          
SEQRES  11 I  808  ALA GLU ASP GLU SER ASN LEU LEU LEU PRO LYS LEU PRO          
SEQRES  12 I  808  THR LEU PRO LYS ASN TYR SER ASN THR SER LYS ILE PHE          
SEQRES  13 I  808  SER GLU GLU ASN SER ASP GLU ILE ILE LYS LEU LEU GLY          
SEQRES  14 I  808  ASP VAL ARG LEU ASN ILE LEU VAL LEU GLY GLY SER SER          
SEQRES  15 I  808  GLY PHE ILE GLU LEU TYR ALA TYR GLY MET PHE LYS ILE          
SEQRES  16 I  808  ALA ARG VAL THR GLY ILE ALA GLY THR CYS LEU ALA LEU          
SEQRES  17 I  808  CYS LEU SER SER ASP LEU LYS SER LEU SER VAL VAL THR          
SEQRES  18 I  808  GLU VAL SER THR ASN GLY ALA SER GLU VAL SER TYR PHE          
SEQRES  19 I  808  GLN LEU GLU THR ASN LEU LEU TYR SER PHE LEU PRO GLU          
SEQRES  20 I  808  VAL THR ARG MET ALA ARG LYS PHE THR HIS ILE SER ALA          
SEQRES  21 I  808  LEU LEU GLN TYR ILE ASN LEU SER LEU THR CYS MET CYS          
SEQRES  22 I  808  GLU ALA TRP GLU GLU ILE LEU MET GLN MET ASP SER ARG          
SEQRES  23 I  808  LEU THR LYS PHE VAL GLN GLU LYS ASN THR THR THR SER          
SEQRES  24 I  808  VAL GLN ASP GLU PHE MET HIS LEU LEU LEU TRP GLY LYS          
SEQRES  25 I  808  ALA SER ALA GLU LEU GLN THR LEU LEU MET ASN GLN LEU          
SEQRES  26 I  808  THR VAL LYS GLY LEU LYS LYS LEU GLY GLN SER ILE GLU          
SEQRES  27 I  808  SER SER TYR SER SER ILE GLN LYS LEU VAL ILE SER HIS          
SEQRES  28 I  808  LEU GLN SER GLY SER GLU SER LEU LEU TYR HIS LEU SER          
SEQRES  29 I  808  GLU LEU LYS GLY MET ALA SER TRP LYS GLN LYS TYR GLU          
SEQRES  30 I  808  PRO LEU GLY LEU ASP ALA ALA GLY ILE GLU GLU ALA ILE          
SEQRES  31 I  808  THR ALA VAL GLY SER PHE ILE LEU LYS ALA ASN GLU LEU          
SEQRES  32 I  808  LEU GLN VAL ILE ASP SER SER MET LYS ASN PHE LYS ALA          
SEQRES  33 I  808  PHE PHE ARG TRP LEU TYR VAL ALA MET LEU ARG MET THR          
SEQRES  34 I  808  ASP ASP HIS VAL LEU PRO GLU LEU ASN LYS MET THR GLN          
SEQRES  35 I  808  LYS ASP ILE THR PHE VAL ALA GLU PHE LEU THR GLU HIS          
SEQRES  36 I  808  PHE ASN GLU ALA PRO ASP LEU TYR ASN ARG LYS GLY LYS          
SEQRES  37 I  808  TYR PHE ASN VAL GLU ARG VAL GLY GLN TYR LEU LYS ASP          
SEQRES  38 I  808  GLU ASP ASP ASP LEU VAL SER PRO PRO ASN THR GLU GLY          
SEQRES  39 I  808  ASN GLN TRP TYR ASP PHE LEU GLN ASN SER SER HIS LEU          
SEQRES  40 I  808  LYS GLU SER PRO LEU LEU PHE PRO TYR TYR PRO ARG LYS          
SEQRES  41 I  808  SER LEU HIS PHE VAL LYS ARG ARG MET GLU ASN ILE ILE          
SEQRES  42 I  808  ASP GLN CYS LEU GLN LYS PRO ALA ASP VAL ILE GLY LYS          
SEQRES  43 I  808  SER MET ASN GLN ALA ILE CYS ILE PRO LEU TYR ARG ASP          
SEQRES  44 I  808  THR ARG SER GLU ASP SER THR ARG ARG LEU PHE LYS PHE          
SEQRES  45 I  808  PRO PHE LEU TRP ASN ASN LYS THR SER ASN LEU HIS TYR          
SEQRES  46 I  808  LEU LEU PHE THR ILE LEU GLU ASP SER LEU TYR LYS MET          
SEQRES  47 I  808  CYS ILE LEU ARG ARG HIS THR ASP ILE SER GLN SER VAL          
SEQRES  48 I  808  SER ASN GLY LEU ILE ALA ILE LYS PHE GLY SER PHE THR          
SEQRES  49 I  808  TYR ALA THR THR GLU LYS VAL ARG ARG SER ILE TYR SER          
SEQRES  50 I  808  CYS LEU ASP ALA GLN PHE TYR ASP ASP GLU THR VAL THR          
SEQRES  51 I  808  VAL VAL LEU LYS ASP THR VAL GLY ARG GLU GLY ARG ASP          
SEQRES  52 I  808  ARG LEU LEU VAL GLN LEU PRO LEU SER LEU VAL TYR ASN          
SEQRES  53 I  808  SER GLU ASP SER ALA GLU TYR GLN PHE THR GLY THR TYR          
SEQRES  54 I  808  SER THR ARG LEU ASP GLU GLN CYS SER ALA ILE PRO THR          
SEQRES  55 I  808  ARG THR MET HIS PHE GLU LYS HIS TRP ARG LEU LEU GLU          
SEQRES  56 I  808  SER MET LYS ALA GLN TYR VAL ALA GLY ASN GLY PHE ARG          
SEQRES  57 I  808  LYS VAL SER CYS VAL LEU SER SER ASN LEU ARG HIS VAL          
SEQRES  58 I  808  ARG VAL PHE GLU MET ASP ILE ASP ASP GLU TRP GLU LEU          
SEQRES  59 I  808  ASP GLU SER SER ASP GLU GLU GLU GLU ALA SER ASN LYS          
SEQRES  60 I  808  PRO VAL LYS ILE LYS GLU GLU VAL LEU SER GLU SER GLU          
SEQRES  61 I  808  ALA GLU ASN GLN GLN ALA GLY ALA ALA ALA LEU ALA PRO          
SEQRES  62 I  808  GLU ILE VAL ILE LYS VAL GLU LYS LEU ASP PRO GLU LEU          
SEQRES  63 I  808  ASP SER                                                      
SEQRES   1 J  620  MET ASN LEU GLU ARG LEU ARG LYS ARG VAL ARG GLN TYR          
SEQRES   2 J  620  LEU ASP GLN GLN GLN TYR GLN SER ALA LEU PHE TRP ALA          
SEQRES   3 J  620  ASP LYS VAL ALA SER LEU SER ARG GLU GLU PRO GLN ASP          
SEQRES   4 J  620  ILE TYR TRP LEU ALA GLN CYS LEU TYR LEU THR ALA GLN          
SEQRES   5 J  620  TYR HIS ARG ALA ALA HIS ALA LEU ARG SER ARG LYS LEU          
SEQRES   6 J  620  ASP LYS LEU TYR GLU ALA CYS ARG TYR LEU ALA ALA ARG          
SEQRES   7 J  620  CYS HIS TYR ALA ALA LYS GLU HIS GLN GLN ALA LEU ASP          
SEQRES   8 J  620  VAL LEU ASP MET GLU GLU PRO ILE ASN LYS ARG LEU PHE          
SEQRES   9 J  620  GLU LYS TYR LEU LYS ASP GLU SER GLY PHE LYS ASP PRO          
SEQRES  10 J  620  SER SER ASP TRP GLU MET SER GLN SER SER ILE LYS SER          
SEQRES  11 J  620  SER ILE CYS LEU LEU ARG GLY LYS ILE TYR ASP ALA LEU          
SEQRES  12 J  620  ASP ASN ARG THR LEU ALA THR TYR SER TYR LYS GLU ALA          
SEQRES  13 J  620  LEU LYS LEU ASP VAL TYR CYS PHE GLU ALA PHE ASP LEU          
SEQRES  14 J  620  LEU THR SER HIS HIS MET LEU THR ALA GLN GLU GLU LYS          
SEQRES  15 J  620  GLU LEU LEU GLU SER LEU PRO LEU SER LYS LEU CYS ASN          
SEQRES  16 J  620  GLU GLU GLN GLU LEU LEU ARG PHE LEU PHE GLU ASN LYS          
SEQRES  17 J  620  LEU LYS LYS TYR ASN LYS PRO SER GLU THR VAL ILE PRO          
SEQRES  18 J  620  GLU SER VAL ASN GLY LEU GLU LYS ASN LEU ASP VAL VAL          
SEQRES  19 J  620  VAL SER LEU ALA GLU ARG HIS TYR TYR ASN CYS ASP PHE          
SEQRES  20 J  620  LYS MET CYS TYR LYS LEU THR SER VAL VAL MET GLU LYS          
SEQRES  21 J  620  ASP PRO PHE HIS ALA SER CYS LEU PRO VAL HIS ILE GLY          
SEQRES  22 J  620  THR LEU VAL GLU LEU ASN LYS ALA ASN GLU LEU PHE TYR          
SEQRES  23 J  620  LEU SER HIS LYS LEU VAL ASP LEU TYR PRO SER ASN PRO          
SEQRES  24 J  620  VAL SER TRP PHE ALA VAL GLY CYS TYR TYR LEU MET VAL          
SEQRES  25 J  620  GLY HIS LYS ASN GLU HIS ALA ARG ARG TYR LEU SER LYS          
SEQRES  26 J  620  ALA THR THR LEU GLU LYS THR TYR GLY PRO ALA TRP ILE          
SEQRES  27 J  620  ALA TYR GLY HIS SER PHE ALA VAL GLU SER GLU HIS ASP          
SEQRES  28 J  620  GLN ALA MET ALA ALA TYR PHE THR ALA ALA GLN LEU MET          
SEQRES  29 J  620  LYS GLY CYS HIS LEU PRO MET LEU TYR ILE GLY LEU GLU          
SEQRES  30 J  620  TYR GLY LEU THR ASN ASN SER LYS LEU ALA GLU ARG PHE          
SEQRES  31 J  620  PHE SER GLN ALA LEU SER ILE ALA PRO GLU ASP PRO PHE          
SEQRES  32 J  620  VAL MET HIS GLU VAL GLY VAL VAL ALA PHE GLN ASN GLY          
SEQRES  33 J  620  GLU TRP LYS THR ALA GLU LYS TRP PHE LEU ASP ALA LEU          
SEQRES  34 J  620  GLU LYS ILE LYS ALA ILE GLY ASN GLU VAL THR VAL ASP          
SEQRES  35 J  620  LYS TRP GLU PRO LEU LEU ASN ASN LEU GLY HIS VAL CYS          
SEQRES  36 J  620  ARG LYS LEU LYS LYS TYR ALA GLU ALA LEU ASP TYR HIS          
SEQRES  37 J  620  ARG GLN ALA LEU VAL LEU ILE PRO GLN ASN ALA SER THR          
SEQRES  38 J  620  TYR SER ALA ILE GLY TYR ILE HIS SER LEU MET GLY ASN          
SEQRES  39 J  620  PHE GLU ASN ALA VAL ASP TYR PHE HIS THR ALA LEU GLY          
SEQRES  40 J  620  LEU ARG ARG ASP ASP THR PHE SER VAL THR MET LEU GLY          
SEQRES  41 J  620  HIS CYS ILE GLU MET TYR ILE GLY ASP SER GLU ALA TYR          
SEQRES  42 J  620  ILE GLY ALA ASP ILE LYS ASP LYS LEU LYS CYS TYR ASP          
SEQRES  43 J  620  PHE ASP VAL HIS THR MET LYS THR LEU LYS ASN ILE ILE          
SEQRES  44 J  620  SER PRO PRO TRP ASP PHE ARG GLU PHE GLU VAL GLU LYS          
SEQRES  45 J  620  GLN THR ALA GLU GLU THR GLY LEU THR PRO LEU GLU THR          
SEQRES  46 J  620  SER ARG LYS THR PRO ASP SER ARG PRO SER LEU GLU GLU          
SEQRES  47 J  620  THR PHE GLU ILE GLU MET ASN GLU SER ASP MET MET LEU          
SEQRES  48 J  620  GLU THR SER MET SER ASP HIS SER THR                          
SEQRES   1 K  620  MET ASN LEU GLU ARG LEU ARG LYS ARG VAL ARG GLN TYR          
SEQRES   2 K  620  LEU ASP GLN GLN GLN TYR GLN SER ALA LEU PHE TRP ALA          
SEQRES   3 K  620  ASP LYS VAL ALA SER LEU SER ARG GLU GLU PRO GLN ASP          
SEQRES   4 K  620  ILE TYR TRP LEU ALA GLN CYS LEU TYR LEU THR ALA GLN          
SEQRES   5 K  620  TYR HIS ARG ALA ALA HIS ALA LEU ARG SER ARG LYS LEU          
SEQRES   6 K  620  ASP LYS LEU TYR GLU ALA CYS ARG TYR LEU ALA ALA ARG          
SEQRES   7 K  620  CYS HIS TYR ALA ALA LYS GLU HIS GLN GLN ALA LEU ASP          
SEQRES   8 K  620  VAL LEU ASP MET GLU GLU PRO ILE ASN LYS ARG LEU PHE          
SEQRES   9 K  620  GLU LYS TYR LEU LYS ASP GLU SER GLY PHE LYS ASP PRO          
SEQRES  10 K  620  SER SER ASP TRP GLU MET SER GLN SER SER ILE LYS SER          
SEQRES  11 K  620  SER ILE CYS LEU LEU ARG GLY LYS ILE TYR ASP ALA LEU          
SEQRES  12 K  620  ASP ASN ARG THR LEU ALA THR TYR SER TYR LYS GLU ALA          
SEQRES  13 K  620  LEU LYS LEU ASP VAL TYR CYS PHE GLU ALA PHE ASP LEU          
SEQRES  14 K  620  LEU THR SER HIS HIS MET LEU THR ALA GLN GLU GLU LYS          
SEQRES  15 K  620  GLU LEU LEU GLU SER LEU PRO LEU SER LYS LEU CYS ASN          
SEQRES  16 K  620  GLU GLU GLN GLU LEU LEU ARG PHE LEU PHE GLU ASN LYS          
SEQRES  17 K  620  LEU LYS LYS TYR ASN LYS PRO SER GLU THR VAL ILE PRO          
SEQRES  18 K  620  GLU SER VAL ASP GLY LEU GLU LYS ASN LEU ASP VAL VAL          
SEQRES  19 K  620  VAL SER LEU ALA GLU ARG HIS TYR TYR ASN CYS ASP PHE          
SEQRES  20 K  620  LYS MET CYS TYR LYS LEU THR SER VAL VAL MET GLU LYS          
SEQRES  21 K  620  ASP PRO PHE HIS LYS SER CYS LEU PRO VAL HIS ILE GLY          
SEQRES  22 K  620  THR LEU VAL GLU LEU ASN LYS ALA ASN GLU LEU PHE TYR          
SEQRES  23 K  620  LEU SER HIS LYS LEU VAL ASP LEU TYR PRO SER ASN PRO          
SEQRES  24 K  620  VAL SER TRP PHE ALA VAL GLY CYS TYR TYR LEU MET VAL          
SEQRES  25 K  620  GLY HIS LYS ASN GLU HIS ALA ARG ARG TYR LEU SER LYS          
SEQRES  26 K  620  ALA THR THR LEU GLU LYS THR TYR GLY PRO ALA TRP ILE          
SEQRES  27 K  620  ALA TYR GLY HIS SER PHE ALA VAL GLU SER GLU HIS ASP          
SEQRES  28 K  620  GLN ALA MET ALA ALA TYR PHE THR ALA ALA GLN LEU MET          
SEQRES  29 K  620  LYS GLY CYS HIS LEU PRO MET LEU TYR ILE GLY LEU GLU          
SEQRES  30 K  620  TYR GLY LEU THR ASN ASN SER LYS LEU ALA GLU ARG PHE          
SEQRES  31 K  620  PHE SER GLN ALA LEU SER ILE ALA PRO GLU ASP PRO PHE          
SEQRES  32 K  620  VAL MET HIS GLU VAL GLY VAL VAL ALA PHE GLN ASN GLY          
SEQRES  33 K  620  GLU TRP LYS THR ALA GLU LYS TRP PHE LEU ASP ALA LEU          
SEQRES  34 K  620  GLU LYS ILE LYS ALA ILE GLY ASN GLU VAL THR VAL ASP          
SEQRES  35 K  620  LYS TRP GLU PRO LEU LEU ASN ASN LEU GLY HIS VAL CYS          
SEQRES  36 K  620  ARG LYS LEU LYS LYS TYR ALA GLU ALA LEU ASP TYR HIS          
SEQRES  37 K  620  ARG GLN ALA LEU VAL LEU ILE PRO GLN ASN ALA SER THR          
SEQRES  38 K  620  TYR SER ALA ILE GLY TYR ILE HIS SER LEU MET GLY ASN          
SEQRES  39 K  620  PHE GLU ASN ALA VAL ASP TYR PHE HIS THR ALA LEU GLY          
SEQRES  40 K  620  LEU ARG ARG ASP ASP THR PHE SER VAL THR MET LEU GLY          
SEQRES  41 K  620  HIS CYS ILE GLU MET TYR ILE GLY ASP SER GLU ALA TYR          
SEQRES  42 K  620  ILE GLY ALA ASP ILE LYS ASP LYS LEU LYS CYS TYR ASP          
SEQRES  43 K  620  PHE ASP VAL HIS THR MET LYS THR LEU LYS ASN ILE ILE          
SEQRES  44 K  620  SER PRO PRO TRP ASP PHE ARG GLU PHE GLU VAL GLU LYS          
SEQRES  45 K  620  GLN THR ALA GLU GLU THR GLY LEU THR PRO LEU GLU THR          
SEQRES  46 K  620  SER ARG LYS THR PRO ASP SER ARG PRO SER LEU GLU GLU          
SEQRES  47 K  620  THR PHE GLU ILE GLU MET ASN GLU SER ASP MET MET LEU          
SEQRES  48 K  620  GLU THR SER MET SER ASP HIS SER THR                          
SEQRES   1 L  183  THR THR PRO ASN LYS THR PRO PRO GLY ALA ASP PRO LYS          
SEQRES   2 L  183  GLN LEU GLU ARG THR GLY THR VAL ARG GLU ILE GLY SER          
SEQRES   3 L  183  GLN ALA VAL TRP SER LEU SER SER CYS LYS PRO GLY PHE          
SEQRES   4 L  183  GLY VAL ASP GLN LEU ARG ASP ASP ASN LEU GLU THR TYR          
SEQRES   5 L  183  TRP GLN SER ASP GLY SER GLN PRO HIS LEU VAL ASN ILE          
SEQRES   6 L  183  GLN PHE ARG ARG LYS THR THR VAL LYS THR LEU CYS ILE          
SEQRES   7 L  183  TYR ALA ASP TYR LYS SER ASP GLU SER TYR THR PRO SER          
SEQRES   8 L  183  LYS ILE SER VAL ARG VAL GLY ASN ASN PHE HIS ASN LEU          
SEQRES   9 L  183  GLN GLU ILE ARG GLN LEU GLU LEU VAL GLU PRO SER GLY          
SEQRES  10 L  183  TRP ILE HIS VAL PRO LEU THR ASP ASN HIS LYS LYS PRO          
SEQRES  11 L  183  THR ARG THR PHE MET ILE GLN ILE ALA VAL LEU ALA ASN          
SEQRES  12 L  183  HIS GLN ASN GLY ARG ASP THR HIS MET ARG GLN ILE LYS          
SEQRES  13 L  183  ILE TYR THR PRO VAL GLU SER SER ILE GLY LYS PHE PRO          
SEQRES  14 L  183  ARG CYS THR THR ILE ASP PHE MET MET TYR ARG SER ILE          
SEQRES  15 L  183  ARG                                                          
SEQRES   1 M   74  MET ASP SER GLU VAL GLN ARG ASP GLY ARG ILE LEU ASP          
SEQRES   2 M   74  LEU ILE ASP ASP ALA TRP ARG GLU ASP LYS LEU PRO TYR          
SEQRES   3 M   74  GLU ASP VAL ALA ILE PRO LEU ASN GLU LEU PRO GLU PRO          
SEQRES   4 M   74  GLU GLN ASP ASN GLY GLY THR THR GLU SER VAL LYS GLU          
SEQRES   5 M   74  GLN GLU MET LYS TRP THR ASP LEU ALA LEU GLN TYR LEU          
SEQRES   6 M   74  HIS GLU ASN VAL PRO PRO ILE GLY ASN                          
SEQRES   1 N  822  MET ALA ALA ALA VAL VAL VAL ALA GLU GLY ASP SER ASP          
SEQRES   2 N  822  SER ARG PRO GLY GLN GLU LEU LEU VAL ALA TRP ASN THR          
SEQRES   3 N  822  VAL SER THR GLY LEU VAL PRO PRO ALA ALA LEU GLY LEU          
SEQRES   4 N  822  VAL SER SER ARG THR SER GLY ALA VAL PRO PRO LYS GLU          
SEQRES   5 N  822  GLU GLU LEU ARG ALA ALA VAL GLU VAL LEU ARG GLY HIS          
SEQRES   6 N  822  GLY LEU HIS SER VAL LEU GLU GLU TRP PHE VAL GLU VAL          
SEQRES   7 N  822  LEU GLN ASN ASP LEU GLN ALA ASN ILE SER PRO GLU PHE          
SEQRES   8 N  822  TRP ASN ALA ILE SER GLN CYS GLU ASN SER ALA ASP GLU          
SEQRES   9 N  822  PRO GLN CYS LEU LEU LEU LEU LEU ASP ALA PHE GLY LEU          
SEQRES  10 N  822  LEU GLU SER ARG LEU ASP PRO TYR LEU ARG SER LEU GLU          
SEQRES  11 N  822  LEU LEU GLU LYS TRP THR ARG LEU GLY LEU LEU MET GLY          
SEQRES  12 N  822  THR GLY ALA GLN GLY LEU ARG GLU GLU VAL HIS THR MET          
SEQRES  13 N  822  LEU ARG GLY VAL LEU PHE PHE SER THR PRO ARG THR PHE          
SEQRES  14 N  822  GLN GLU MET ILE GLN ARG LEU TYR GLY CYS PHE LEU ARG          
SEQRES  15 N  822  VAL TYR MET GLN SER LYS ARG LYS GLY GLU GLY GLY THR          
SEQRES  16 N  822  ASP PRO GLU LEU GLU GLY GLU LEU ASP SER ARG TYR ALA          
SEQRES  17 N  822  ARG ARG ARG TYR TYR ARG LEU LEU GLN SER PRO LEU CYS          
SEQRES  18 N  822  ALA GLY CYS SER SER ASP LYS GLN GLN CYS TRP CYS ARG          
SEQRES  19 N  822  GLN ALA LEU GLU GLN PHE HIS GLN LEU SER GLN VAL LEU          
SEQRES  20 N  822  HIS ARG LEU SER LEU LEU GLU ARG VAL SER ALA GLU ALA          
SEQRES  21 N  822  VAL THR THR THR LEU HIS GLN VAL THR ARG GLU ARG MET          
SEQRES  22 N  822  GLU ASP ARG CYS ARG GLY GLU TYR GLU ARG SER PHE LEU          
SEQRES  23 N  822  ARG GLU PHE HIS LYS TRP ILE GLU ARG VAL VAL GLY TRP          
SEQRES  24 N  822  LEU GLY LYS VAL PHE LEU GLN ASP GLY PRO ALA ARG PRO          
SEQRES  25 N  822  ALA SER PRO GLU ALA GLY ASN THR LEU ARG ARG TRP ARG          
SEQRES  26 N  822  CYS HIS VAL GLN ARG PHE PHE TYR ARG ILE TYR ALA SER          
SEQRES  27 N  822  LEU ARG ILE GLU GLU LEU PHE SER ILE VAL ARG ASP PHE          
SEQRES  28 N  822  PRO ASP SER ARG PRO ALA ILE GLU ASP LEU LYS TYR CYS          
SEQRES  29 N  822  LEU GLU ARG THR ASP GLN ARG GLN GLN LEU LEU VAL SER          
SEQRES  30 N  822  LEU LYS ALA ALA LEU GLU THR ARG LEU LEU HIS PRO GLY          
SEQRES  31 N  822  VAL ASN THR CYS ASP ILE ILE THR LEU TYR ILE SER ALA          
SEQRES  32 N  822  ILE LYS ALA LEU ARG VAL ILE ASP PRO SER MET VAL ILE          
SEQRES  33 N  822  LEU GLU VAL ALA CYS GLU PRO ILE ARG ARG TYR LEU ARG          
SEQRES  34 N  822  THR ARG GLU ASP THR VAL ARG GLN ILE VAL ALA GLY LEU          
SEQRES  35 N  822  THR GLY ASP SER ASP GLY THR GLY ASP LEU ALA VAL GLU          
SEQRES  36 N  822  LEU SER LYS THR ASP PRO ALA SER LEU GLU THR GLY GLN          
SEQRES  37 N  822  ASP SER GLU ASP ASP SER GLY GLU PRO GLU ASP TRP VAL          
SEQRES  38 N  822  PRO ASP PRO VAL ASP ALA ASP PRO GLY LYS SER SER SER          
SEQRES  39 N  822  LYS ARG ARG SER SER ASP ILE ILE SER LEU LEU VAL SER          
SEQRES  40 N  822  ILE TYR GLY SER LYS ASP LEU PHE ILE ASN GLU TYR ARG          
SEQRES  41 N  822  SER LEU LEU ALA ASP ARG LEU LEU HIS GLN PHE SER PHE          
SEQRES  42 N  822  SER PRO GLU ARG GLU ILE ARG ASN VAL GLU LEU LEU LYS          
SEQRES  43 N  822  LEU ARG PHE GLY GLU ALA PRO MET HIS PHE CYS GLU VAL          
SEQRES  44 N  822  MET LEU LYS ASP MET ALA ASP SER ARG ARG ILE ASN ALA          
SEQRES  45 N  822  ASN ILE ARG GLU GLU ASP GLU LYS ARG PRO ALA GLU GLU          
SEQRES  46 N  822  GLN PRO PRO PHE GLY VAL TYR ALA VAL ILE LEU SER SER          
SEQRES  47 N  822  GLU PHE TRP PRO PRO PHE LYS ASP GLU LYS LEU GLU VAL          
SEQRES  48 N  822  PRO GLU ASP ILE ARG ALA ALA LEU GLU ALA TYR CYS LYS          
SEQRES  49 N  822  LYS TYR GLU GLN LEU LYS ALA MET ARG THR LEU SER TRP          
SEQRES  50 N  822  LYS HIS THR LEU GLY LEU VAL THR MET ASP VAL GLU LEU          
SEQRES  51 N  822  ALA ASP ARG THR LEU SER VAL ALA VAL THR PRO VAL GLN          
SEQRES  52 N  822  ALA VAL ILE LEU LEU TYR PHE GLN ASP GLN ALA SER TRP          
SEQRES  53 N  822  THR LEU GLU GLU LEU SER LYS ALA VAL LYS MET PRO VAL          
SEQRES  54 N  822  ALA LEU LEU ARG ARG ARG MET SER VAL TRP LEU GLN GLN          
SEQRES  55 N  822  GLY VAL LEU ARG GLU GLU PRO PRO GLY THR PHE SER VAL          
SEQRES  56 N  822  ILE GLU GLU GLU ARG PRO GLN ASP ARG ASP ASN MET VAL          
SEQRES  57 N  822  LEU ILE ASP SER ASP ASP GLU SER ASP SER GLY MET ALA          
SEQRES  58 N  822  SER GLN ALA ASP GLN LYS GLU GLU GLU LEU LEU LEU PHE          
SEQRES  59 N  822  TRP THR TYR ILE GLN ALA MET LEU THR ASN LEU GLU SER          
SEQRES  60 N  822  LEU SER LEU ASP ARG ILE TYR ASN MET LEU ARG MET PHE          
SEQRES  61 N  822  VAL VAL THR GLY PRO ALA LEU ALA GLU ILE ASP LEU GLN          
SEQRES  62 N  822  GLU LEU GLN GLY TYR LEU GLN LYS LYS VAL ARG ASP GLN          
SEQRES  63 N  822  GLN LEU VAL TYR SER ALA GLY VAL TYR ARG LEU PRO LYS          
SEQRES  64 N  822  ASN CYS SER                                                  
SEQRES   1 O  756  MET ALA SER VAL HIS GLU SER LEU TYR PHE ASN PRO MET          
SEQRES   2 O  756  MET THR ASN GLY VAL VAL HIS ALA ASN VAL PHE GLY ILE          
SEQRES   3 O  756  LYS ASP TRP VAL THR PRO TYR LYS ILE ALA VAL LEU VAL          
SEQRES   4 O  756  LEU LEU SER GLU MET SER ARG THR GLY GLU GLY ALA VAL          
SEQRES   5 O  756  SER LEU VAL GLU ARG ARG ARG LEU ASN GLN GLN LEU LEU          
SEQRES   6 O  756  PRO LEU LEU GLN GLY PRO ASP ILE THR VAL SER LYS LEU          
SEQRES   7 O  756  LEU LYS LEU ILE GLU GLU SER CYS PRO GLN LEU ALA ASN          
SEQRES   8 O  756  SER VAL GLN ILE ARG ILE LYS LEU MET ALA GLU GLY GLU          
SEQRES   9 O  756  LEU LYS ASP MET GLU GLN PHE PHE ASP ASP LEU SER ASP          
SEQRES  10 O  756  SER PHE SER GLY THR GLU PRO GLU VAL HIS LYS THR SER          
SEQRES  11 O  756  VAL VAL GLY LEU PHE LEU ARG HIS MET ILE LEU ALA TYR          
SEQRES  12 O  756  SER LYS LEU SER PHE SER GLN VAL PHE LYS LEU TYR THR          
SEQRES  13 O  756  ALA LEU GLN GLN TYR PHE GLN SER ASP GLU ASN LYS LYS          
SEQRES  14 O  756  THR VAL GLU ASP ALA ASP MET GLU LEU THR SER ARG ASP          
SEQRES  15 O  756  GLU GLY GLU ARG LYS MET GLU LYS GLU GLU LEU ASP VAL          
SEQRES  16 O  756  SER VAL ARG GLU GLU GLU VAL SER CYS SER GLY PRO LEU          
SEQRES  17 O  756  SER GLN LYS GLN ALA GLU PHE PHE LEU SER GLN GLN ALA          
SEQRES  18 O  756  SER LEU LEU LYS ASN ASP GLU THR LYS ALA LEU THR PRO          
SEQRES  19 O  756  ALA SER LEU GLN LYS GLU LEU ASN ASN LEU LEU LYS PHE          
SEQRES  20 O  756  ASN PRO ASP PHE ALA GLU ALA HIS TYR LEU SER TYR LEU          
SEQRES  21 O  756  ASN ASN LEU ARG VAL GLN ASP VAL PHE SER SER THR HIS          
SEQRES  22 O  756  SER LEU LEU HIS TYR PHE ASP ARG LEU ILE LEU THR GLY          
SEQRES  23 O  756  ALA GLU SER LYS SER ASN GLY GLU GLU GLY TYR GLY ARG          
SEQRES  24 O  756  SER LEU ARG TYR ALA ALA LEU ASN LEU ALA ALA LEU HIS          
SEQRES  25 O  756  CYS ARG PHE GLY HIS TYR GLN GLN ALA GLU LEU ALA LEU          
SEQRES  26 O  756  GLN GLU ALA ILE ARG ILE ALA GLN GLU SER ASN ASP HIS          
SEQRES  27 O  756  VAL CYS LEU GLN HIS CYS LEU SER TRP LEU TYR VAL LEU          
SEQRES  28 O  756  GLY GLN LYS ARG SER ASP SER TYR VAL LEU LEU GLU HIS          
SEQRES  29 O  756  SER VAL LYS LYS ALA VAL HIS PHE GLY LEU PRO TYR LEU          
SEQRES  30 O  756  ALA SER LEU GLY ILE GLN SER LEU VAL GLN GLN ARG ALA          
SEQRES  31 O  756  PHE ALA GLY LYS THR ALA ASN LYS LEU MET ASP ALA LEU          
SEQRES  32 O  756  LYS ASP SER ASP LEU LEU HIS TRP LYS HIS SER LEU SER          
SEQRES  33 O  756  GLU LEU ILE ASP ILE SER ILE ALA GLN LYS THR ALA ILE          
SEQRES  34 O  756  TRP ARG LEU TYR GLY ARG SER THR MET ALA LEU GLN GLN          
SEQRES  35 O  756  ALA GLN MET LEU LEU SER MET ASN SER LEU GLU ALA VAL          
SEQRES  36 O  756  ASN ALA GLY VAL GLN GLN ASN ASN THR GLU SER PHE ALA          
SEQRES  37 O  756  VAL ALA LEU CYS HIS LEU ALA GLU LEU HIS ALA GLU GLN          
SEQRES  38 O  756  GLY CYS PHE ALA ALA ALA SER GLU VAL LEU LYS HIS LEU          
SEQRES  39 O  756  LYS GLU ARG PHE PRO PRO ASN SER GLN HIS ALA GLN LEU          
SEQRES  40 O  756  TRP MET LEU CYS ASP GLN LYS ILE GLN PHE ASP ARG ALA          
SEQRES  41 O  756  MET ASN ASP GLY LYS TYR HIS LEU ALA ASP SER LEU VAL          
SEQRES  42 O  756  THR GLY ILE THR ALA LEU ASN SER ILE GLU GLY VAL TYR          
SEQRES  43 O  756  ARG LYS ALA VAL VAL LEU GLN ALA GLN ASN GLN MET SER          
SEQRES  44 O  756  GLU ALA HIS LYS LEU LEU GLN LYS LEU LEU VAL HIS CYS          
SEQRES  45 O  756  GLN LYS LEU LYS ASN THR GLU MET VAL ILE SER VAL LEU          
SEQRES  46 O  756  LEU SER VAL ALA GLU LEU TYR TRP ARG SER SER SER PRO          
SEQRES  47 O  756  THR ILE ALA LEU PRO MET LEU LEU GLN ALA LEU ALA LEU          
SEQRES  48 O  756  SER LYS GLU TYR ARG LEU GLN TYR LEU ALA SER GLU THR          
SEQRES  49 O  756  VAL LEU ASN LEU ALA PHE ALA GLN LEU ILE LEU GLY ILE          
SEQRES  50 O  756  PRO GLU GLN ALA LEU SER LEU LEU HIS MET ALA ILE GLU          
SEQRES  51 O  756  PRO ILE LEU ALA ASP GLY ALA ILE LEU ASP LYS GLY ARG          
SEQRES  52 O  756  ALA MET PHE LEU VAL ALA LYS CYS GLN VAL ALA SER ALA          
SEQRES  53 O  756  ALA SER TYR ASP GLN PRO LYS LYS ALA GLU ALA LEU GLU          
SEQRES  54 O  756  ALA ALA ILE GLU ASN LEU ASN GLU ALA LYS ASN TYR PHE          
SEQRES  55 O  756  ALA LYS VAL ASP CYS LYS GLU ARG ILE ARG ASP VAL VAL          
SEQRES  56 O  756  TYR PHE GLN ALA ARG LEU TYR HIS THR LEU GLY LYS THR          
SEQRES  57 O  756  GLN GLU ARG ASN ARG CYS ALA MET LEU PHE ARG GLN LEU          
SEQRES  58 O  756  HIS GLN GLU LEU PRO SER HIS GLY VAL PRO LEU ILE ASN          
SEQRES  59 O  756  HIS LEU                                                      
SEQRES   1 P  591  MET VAL PRO VAL ALA VAL THR ALA ALA VAL ALA PRO VAL          
SEQRES   2 P  591  LEU SER ILE ASN SER ASP PHE SER ASP LEU ARG GLU ILE          
SEQRES   3 P  591  LYS LYS GLN LEU LEU LEU ILE ALA GLY LEU THR ARG GLU          
SEQRES   4 P  591  ARG GLY LEU LEU HIS SER SER LYS TRP SER ALA GLU LEU          
SEQRES   5 P  591  ALA PHE SER LEU PRO ALA LEU PRO LEU ALA GLU LEU GLN          
SEQRES   6 P  591  PRO PRO PRO PRO ILE THR GLU GLU ASP ALA GLN ASP MET          
SEQRES   7 P  591  ASP ALA TYR THR LEU ALA LYS ALA TYR PHE ASP VAL LYS          
SEQRES   8 P  591  GLU TYR ASP ARG ALA ALA HIS PHE LEU HIS GLY CYS ASN          
SEQRES   9 P  591  SER LYS LYS ALA TYR PHE LEU TYR MET TYR SER ARG TYR          
SEQRES  10 P  591  LEU SER GLY GLU LYS LYS LYS ASP ASP GLU THR VAL ASP          
SEQRES  11 P  591  SER LEU GLY PRO LEU GLU LYS GLY GLN VAL LYS ASN GLU          
SEQRES  12 P  591  ALA LEU ARG GLU LEU ARG VAL GLU LEU SER LYS LEU HIS          
SEQRES  13 P  591  GLN ALA ARG GLU LEU ASP GLY PHE GLY LEU TYR LEU TYR          
SEQRES  14 P  591  GLY VAL VAL LEU ARG LYS LEU ASP LEU VAL LYS GLU ALA          
SEQRES  15 P  591  ILE ASP VAL PHE VAL GLU ALA THR HIS VAL LEU PRO LEU          
SEQRES  16 P  591  HIS TRP GLY ALA TRP LEU GLU LEU CYS ASN LEU ILE THR          
SEQRES  17 P  591  ASP LYS GLU MET LEU LYS PHE LEU SER LEU PRO ASP THR          
SEQRES  18 P  591  TRP MET LYS GLU PHE PHE LEU ALA HIS ILE TYR THR GLU          
SEQRES  19 P  591  LEU GLN LEU ILE GLU GLU ALA LEU GLN LYS TYR GLN ASN          
SEQRES  20 P  591  LEU ILE ASP VAL GLY PHE SER LYS SER SER TYR ILE VAL          
SEQRES  21 P  591  SER GLN ILE ALA VAL ALA TYR HIS ASN ILE ARG ASP ILE          
SEQRES  22 P  591  ASP LYS ALA LEU SER ILE PHE ASN GLU LEU ARG LYS GLN          
SEQRES  23 P  591  ASP PRO TYR ARG ILE GLU ASN MET ASP THR PHE SER ASN          
SEQRES  24 P  591  LEU LEU TYR VAL ARG SER MET LYS SER GLU LEU SER TYR          
SEQRES  25 P  591  LEU ALA HIS ASN LEU CYS GLU ILE ASP LYS TYR ARG VAL          
SEQRES  26 P  591  GLU THR CYS CYS VAL ILE GLY ASN TYR TYR SER LEU ARG          
SEQRES  27 P  591  SER GLN HIS GLU LYS ALA ALA LEU TYR PHE GLN ARG ALA          
SEQRES  28 P  591  LEU LYS LEU ASN PRO ARG TYR LEU GLY ALA TRP THR LEU          
SEQRES  29 P  591  MET GLY HIS GLU TYR MET GLU MET LYS ASN THR SER ALA          
SEQRES  30 P  591  ALA ILE GLN ALA TYR ARG HIS ALA ILE GLU VAL ASN LYS          
SEQRES  31 P  591  ARG ASP TYR ARG ALA TRP TYR GLY LEU GLY GLN THR TYR          
SEQRES  32 P  591  GLU ILE LEU LYS MET PRO PHE TYR CYS LEU TYR TYR TYR          
SEQRES  33 P  591  ARG ARG ALA HIS GLN LEU ARG PRO ASN ASP SER ARG MET          
SEQRES  34 P  591  LEU VAL ALA LEU GLY GLU CYS TYR GLU LYS LEU ASN GLN          
SEQRES  35 P  591  LEU VAL GLU ALA LYS LYS CYS TYR TRP ARG ALA TYR ALA          
SEQRES  36 P  591  VAL GLY ASP VAL GLU LYS MET ALA LEU VAL LYS LEU ALA          
SEQRES  37 P  591  LYS LEU HIS GLU GLN LEU THR GLU SER GLU GLN ALA ALA          
SEQRES  38 P  591  GLN CYS TYR ILE LYS TYR ILE GLN ASP ILE TYR SER CYS          
SEQRES  39 P  591  GLY GLU ILE VAL GLU HIS LEU GLU GLU SER THR ALA PHE          
SEQRES  40 P  591  ARG TYR LEU ALA GLN TYR TYR PHE LYS CYS LYS LEU TRP          
SEQRES  41 P  591  ASP GLU ALA SER THR CYS ALA GLN LYS CYS CYS ALA PHE          
SEQRES  42 P  591  ASN ASP THR ARG GLU GLU GLY LYS ALA LEU LEU ARG GLN          
SEQRES  43 P  591  ILE LEU GLN LEU ARG ASN GLN GLY GLU THR PRO THR THR          
SEQRES  44 P  591  GLU VAL PRO ALA PRO PHE PHE LEU PRO ALA SER LEU SER          
SEQRES  45 P  591  ALA ASN ASN THR PRO THR ARG ARG VAL SER PRO LEU ASN          
SEQRES  46 P  591  LEU SER SER VAL THR PRO                                      
SEQRES   1 R  493  MET ASP GLN ASP TYR GLU ARG ARG LEU LEU ARG GLN ILE          
SEQRES   2 R  493  VAL ILE GLN ASN GLU ASN THR MET PRO ARG VAL THR GLU          
SEQRES   3 R  493  MET ARG ARG THR LEU THR PRO ALA SER SER PRO VAL SER          
SEQRES   4 R  493  SER PRO SER LYS HIS GLY ASP ARG PHE ILE PRO SER ARG          
SEQRES   5 R  493  ALA GLY ALA ASN TRP SER VAL ASN PHE HIS ARG ILE ASN          
SEQRES   6 R  493  GLU ASN GLU LYS SER PRO SER GLN ASN ARG LYS ALA LYS          
SEQRES   7 R  493  ASP ALA THR SER ASP ASN GLY LYS ASP GLY LEU ALA TYR          
SEQRES   8 R  493  SER ALA LEU LEU LYS ASN GLU LEU LEU GLY ALA GLY ILE          
SEQRES   9 R  493  GLU LYS VAL GLN ASP PRO GLN THR GLU ASP ARG ARG LEU          
SEQRES  10 R  493  GLN PRO SER THR PRO GLU LYS LYS GLY LEU PHE THR TYR          
SEQRES  11 R  493  SER LEU SER THR LYS ARG SER SER PRO ASP ASP GLY ASN          
SEQRES  12 R  493  ASP VAL SER PRO TYR SER LEU SER PRO VAL SER ASN LYS          
SEQRES  13 R  493  SER GLN LYS LEU LEU ARG SER PRO ARG LYS PRO THR ARG          
SEQRES  14 R  493  LYS ILE SER LYS ILE PRO PHE LYS VAL LEU ASP ALA PRO          
SEQRES  15 R  493  GLU LEU GLN ASP ASP PHE TYR LEU ASN LEU VAL ASP TRP          
SEQRES  16 R  493  SER SER LEU ASN VAL LEU SER VAL GLY LEU GLY THR CYS          
SEQRES  17 R  493  VAL TYR LEU TRP SER ALA CYS THR SER GLN VAL THR ARG          
SEQRES  18 R  493  LEU CYS ASP LEU SER VAL GLU GLY ASP SER VAL THR SER          
SEQRES  19 R  493  VAL GLY TRP SER GLU ARG GLY ASN LEU VAL ALA VAL GLY          
SEQRES  20 R  493  THR HIS LYS GLY PHE VAL GLN ILE TRP ASP ALA ALA ALA          
SEQRES  21 R  493  GLY LYS LYS LEU SER MET LEU GLU GLY HIS THR ALA ARG          
SEQRES  22 R  493  VAL GLY ALA LEU ALA TRP ASN ALA GLU GLN LEU SER SER          
SEQRES  23 R  493  GLY SER ARG ASP ARG MET ILE LEU GLN ARG ASP ILE ARG          
SEQRES  24 R  493  THR PRO PRO LEU GLN SER GLU ARG ARG LEU GLN GLY HIS          
SEQRES  25 R  493  ARG GLN GLU VAL CYS GLY LEU LYS TRP SER THR ASP HIS          
SEQRES  26 R  493  GLN LEU LEU ALA SER GLY GLY ASN ASP ASN LYS LEU LEU          
SEQRES  27 R  493  VAL TRP ASN HIS SER SER LEU SER PRO VAL GLN GLN TYR          
SEQRES  28 R  493  THR GLU HIS LEU ALA ALA VAL LYS ALA ILE ALA TRP SER          
SEQRES  29 R  493  PRO HIS GLN HIS GLY LEU LEU ALA SER GLY GLY GLY THR          
SEQRES  30 R  493  ALA ASP ARG CYS ILE ARG PHE TRP ASN THR LEU THR GLY          
SEQRES  31 R  493  GLN PRO LEU GLN CYS ILE ASP THR GLY SER GLN VAL CYS          
SEQRES  32 R  493  ASN LEU ALA TRP SER LYS HIS ALA ASN GLU LEU VAL SER          
SEQRES  33 R  493  THR HIS GLY TYR SER GLN ASN GLN ILE LEU VAL TRP LYS          
SEQRES  34 R  493  TYR PRO SER LEU THR GLN VAL ALA LYS LEU THR GLY HIS          
SEQRES  35 R  493  SER TYR ARG VAL LEU TYR LEU ALA MET SER PRO ASP GLY          
SEQRES  36 R  493  GLU ALA ILE VAL THR GLY ALA GLY ASP GLU THR LEU ARG          
SEQRES  37 R  493  PHE TRP ASN VAL PHE SER LYS THR ARG SER THR LYS GLU          
SEQRES  38 R  493  SER VAL SER VAL LEU ASN LEU PHE THR ARG ILE ARG              
SEQRES   1 S  447  MET SER ARG ARG PRO CYS SER CYS ALA LEU ARG PRO PRO          
SEQRES   2 S  447  ARG CYS SER CYS SER ALA SER PRO SER ALA VAL THR ALA          
SEQRES   3 S  447  ALA GLY ARG PRO ARG PRO SER ASP SER CYS LYS GLU GLU          
SEQRES   4 S  447  SER SER THR LEU SER VAL LYS MET LYS CYS ASP PHE ASN          
SEQRES   5 S  447  CYS ASN HIS VAL HIS SER GLY LEU LYS LEU VAL LYS PRO          
SEQRES   6 S  447  ASP ASP ILE GLY ARG LEU VAL SER TYR THR PRO ALA TYR          
SEQRES   7 S  447  LEU GLU GLY SER CYS LYS ASP CYS ILE LYS ASP TYR GLU          
SEQRES   8 S  447  ARG LEU SER CYS ILE GLY SER PRO ILE VAL SER PRO ARG          
SEQRES   9 S  447  ILE VAL GLN LEU GLU THR GLU SER LYS ARG LEU HIS ASN          
SEQRES  10 S  447  LYS GLU ASN GLN HIS VAL GLN GLN THR LEU ASN SER THR          
SEQRES  11 S  447  ASN GLU ILE GLU ALA LEU GLU THR SER ARG LEU TYR GLU          
SEQRES  12 S  447  ASP SER GLY TYR SER SER PHE SER LEU GLN SER GLY LEU          
SEQRES  13 S  447  SER GLU HIS GLU GLU GLY SER LEU LEU GLU GLU ASN PHE          
SEQRES  14 S  447  GLY ASP SER LEU GLN SER CYS LEU LEU GLN ILE GLN SER          
SEQRES  15 S  447  PRO ASP GLN TYR PRO ASN LYS ASN LEU LEU PRO VAL LEU          
SEQRES  16 S  447  HIS PHE GLU LYS VAL VAL CYS SER THR LEU LYS LYS ASN          
SEQRES  17 S  447  ALA LYS ARG ASN PRO LYS VAL ASP ARG GLU MET LEU LYS          
SEQRES  18 S  447  GLU ILE ILE ALA ARG GLY ASN PHE ARG LEU GLN ASN ILE          
SEQRES  19 S  447  ILE GLY ARG LYS MET GLY LEU GLU CYS VAL ASP ILE LEU          
SEQRES  20 S  447  SER GLU LEU PHE ARG ARG GLY LEU ARG HIS VAL LEU ALA          
SEQRES  21 S  447  THR ILE LEU ALA GLN LEU SER ASP MET ASP LEU ILE ASN          
SEQRES  22 S  447  VAL SER LYS VAL SER THR THR TRP LYS LYS ILE LEU GLU          
SEQRES  23 S  447  ASP ASP LYS GLY ALA PHE GLN LEU TYR SER LYS ALA ILE          
SEQRES  24 S  447  GLN ARG VAL THR GLU ASN ASN ASN LYS PHE SER PRO HIS          
SEQRES  25 S  447  ALA SER THR ARG GLU TYR VAL MET PHE ARG ILE PRO LEU          
SEQRES  26 S  447  LYS SER VAL GLN LYS SER ALA ALA GLN THR SER LEU LYS          
SEQRES  27 S  447  LYS ASP ALA GLN THR LYS LEU SER ASN GLN GLY ASP GLN          
SEQRES  28 S  447  LYS GLY SER THR TYR SER ARG HIS ASN GLU PHE SER GLU          
SEQRES  29 S  447  VAL ALA LYS THR LEU LYS LYS ASN GLU SER LEU LYS ALA          
SEQRES  30 S  447  CYS ILE ARG CYS ASN SER PRO ALA LYS TYR ASP CYS TYR          
SEQRES  31 S  447  LEU GLN ARG ALA THR CYS LYS ARG GLU GLY CYS GLY PHE          
SEQRES  32 S  447  ASP TYR CYS THR LYS CYS LEU CYS ASN TYR HIS THR THR          
SEQRES  33 S  447  LYS ASP CYS SER ASP GLY LYS LEU LEU LYS ALA SER CYS          
SEQRES  34 S  447  LYS ILE GLY PRO LEU PRO GLY THR LYS LYS SER LYS LYS          
SEQRES  35 S  447  ASN LEU ARG ARG LEU                                          
SEQRES   1 T   21  ALA ALA ALA ALA ALA GLN LEU ALA ALA ALA ALA ALA ALA          
SEQRES   2 T   21  ALA ALA ALA ALA ALA ALA ALA ALA                              
SEQRES   1 U   24  MET SER ARG ARG PRO CYS SER CYS ALA LEU ARG PRO PRO          
SEQRES   2 U   24  ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA                  
SEQRES   1 W   85  MET LEU ARG ARG LYS PRO THR ARG LEU GLU LEU LYS LEU          
SEQRES   2 W   85  ASP ASP ILE GLU GLU PHE GLU ASN ILE ARG LYS ASP LEU          
SEQRES   3 W   85  GLU THR ARG LYS LYS GLN LYS GLU ASP VAL GLU VAL VAL          
SEQRES   4 W   85  GLY GLY SER ASP GLY GLU GLY ALA ILE GLY LEU SER SER          
SEQRES   5 W   85  ASP PRO LYS SER ARG GLU GLN MET ILE ASN ASP ARG ILE          
SEQRES   6 W   85  GLY TYR LYS PRO GLN PRO LYS PRO ASN ASN ARG SER SER          
SEQRES   7 W   85  GLN PHE GLY SER LEU GLU PHE                                  
SEQRES   1 X  565  MET ASN VAL ILE ASP HIS VAL ARG ASP MET ALA ALA ALA          
SEQRES   2 X  565  GLY LEU HIS SER ASN VAL ARG LEU LEU SER SER LEU LEU          
SEQRES   3 X  565  LEU THR LEU SER ASN ASN ASN PRO GLU LEU PHE SER PRO          
SEQRES   4 X  565  PRO GLN LYS TYR GLN LEU LEU VAL TYR HIS ALA ASP SER          
SEQRES   5 X  565  LEU PHE HIS ASP LYS GLU TYR ARG ASN ALA VAL SER LYS          
SEQRES   6 X  565  TYR THR MET ALA LEU GLN GLN LYS LYS ALA LEU SER LYS          
SEQRES   7 X  565  THR SER LYS VAL ARG PRO SER THR GLY ASN SER ALA SER          
SEQRES   8 X  565  THR PRO GLN SER GLN CYS LEU PRO SER GLU ILE GLU VAL          
SEQRES   9 X  565  LYS TYR LYS LEU ALA GLU CYS TYR THR VAL LEU LYS GLN          
SEQRES  10 X  565  ASP LYS ASP ALA ILE ALA ILE LEU ASP GLY ILE PRO SER          
SEQRES  11 X  565  ARG GLN ARG THR PRO LYS ILE ASN MET MET LEU ALA ASN          
SEQRES  12 X  565  LEU TYR LYS LYS ALA GLY GLN GLU ARG PRO SER VAL THR          
SEQRES  13 X  565  SER TYR LYS GLU VAL LEU ARG GLN CYS PRO LEU ALA LEU          
SEQRES  14 X  565  ASP ALA ILE LEU GLY LEU LEU SER LEU SER VAL LYS GLY          
SEQRES  15 X  565  ALA GLU VAL ALA SER MET THR MET ASN VAL ILE GLN THR          
SEQRES  16 X  565  VAL PRO ASN LEU ASP TRP LEU SER VAL TRP ILE LYS ALA          
SEQRES  17 X  565  TYR ALA PHE VAL HIS THR GLY ASP ASN SER ARG ALA ILE          
SEQRES  18 X  565  SER THR ILE CYS SER LEU GLU LYS LYS SER LEU LEU ARG          
SEQRES  19 X  565  ASP ASN VAL ASP LEU LEU GLY SER LEU ALA ASP LEU TYR          
SEQRES  20 X  565  PHE ARG ALA GLY ASP ASN LYS ASN SER VAL LEU LYS PHE          
SEQRES  21 X  565  GLU GLN ALA GLN MET LEU ASP PRO TYR LEU ILE LYS GLY          
SEQRES  22 X  565  MET ASP VAL TYR GLY TYR LEU LEU ALA ARG GLU GLY ARG          
SEQRES  23 X  565  LEU GLU ASP VAL GLU ASN LEU GLY CYS ARG LEU PHE ASN          
SEQRES  24 X  565  ILE SER ASP GLN HIS ALA GLU PRO TRP VAL VAL SER GLY          
SEQRES  25 X  565  CYS HIS SER PHE TYR SER LYS ARG TYR SER ARG ALA LEU          
SEQRES  26 X  565  TYR LEU GLY ALA LYS ALA ILE GLN LEU ASN SER ASN SER          
SEQRES  27 X  565  VAL GLN ALA LEU LEU LEU LYS GLY ALA ALA LEU ARG ASN          
SEQRES  28 X  565  MET GLY ARG VAL GLN GLU ALA ILE ILE HIS PHE ARG GLU          
SEQRES  29 X  565  ALA ILE ARG LEU ALA PRO CYS ARG LEU ASP CYS TYR GLU          
SEQRES  30 X  565  GLY LEU ILE GLU CYS TYR LEU ALA SER ASN SER ILE ARG          
SEQRES  31 X  565  GLU ALA MET VAL MET ALA ASN ASN VAL TYR LYS THR LEU          
SEQRES  32 X  565  GLY ALA ASN ALA GLN THR LEU THR LEU LEU ALA THR VAL          
SEQRES  33 X  565  CYS LEU GLU ASP PRO VAL THR GLN GLU LYS ALA LYS THR          
SEQRES  34 X  565  LEU LEU ASN LYS ALA LEU THR GLN GLU PRO ASP TYR ILE          
SEQRES  35 X  565  LYS ALA VAL VAL LYS LYS ALA GLU LEU LEU SER ARG GLU          
SEQRES  36 X  565  GLN LYS TYR GLU ASP GLY ILE ALA LEU LEU ARG ASN ALA          
SEQRES  37 X  565  LEU ALA ASN GLN SER ASP CYS VAL LEU HIS ARG ILE LEU          
SEQRES  38 X  565  GLY ASP PHE LEU VAL ALA VAL ASN GLU TYR GLN GLU ALA          
SEQRES  39 X  565  MET ASP GLN TYR SER ILE ALA LEU SER LEU ASP PRO ASN          
SEQRES  40 X  565  ASP GLN LYS SER LEU GLU GLY MET GLN LYS MET GLU LYS          
SEQRES  41 X  565  GLU GLU SER PRO THR ASP ALA THR GLN GLU GLU ASP VAL          
SEQRES  42 X  565  ASP ASP MET GLU GLY SER GLY GLU GLU GLY ASP LEU GLU          
SEQRES  43 X  565  GLY SER ASP SER GLU ALA ALA GLN TRP ALA ASP GLN GLU          
SEQRES  44 X  565  GLN TRP PHE GLY MET GLN                                      
SEQRES   1 Y  565  MET ASN VAL ILE ASP HIS VAL ARG ASP MET ALA ALA ALA          
SEQRES   2 Y  565  GLY LEU HIS SER ASN VAL ARG LEU LEU SER SER LEU LEU          
SEQRES   3 Y  565  LEU THR LEU SER ASN ASN ASN PRO GLU LEU PHE SER PRO          
SEQRES   4 Y  565  PRO GLN LYS TYR GLN LEU LEU VAL TYR HIS ALA ASP SER          
SEQRES   5 Y  565  LEU PHE HIS ASP LYS GLU TYR ARG ASN ALA VAL SER LYS          
SEQRES   6 Y  565  TYR THR MET ALA LEU GLN GLN LYS LYS ALA LEU SER LYS          
SEQRES   7 Y  565  THR SER LYS VAL ARG PRO SER THR GLY ASN SER ALA SER          
SEQRES   8 Y  565  THR PRO GLN SER GLN CYS LEU PRO SER GLU ILE GLU VAL          
SEQRES   9 Y  565  LYS TYR LYS LEU ALA GLU CYS TYR THR VAL LEU LYS GLN          
SEQRES  10 Y  565  ASP LYS ASP ALA ILE ALA ILE LEU ASP GLY ILE PRO SER          
SEQRES  11 Y  565  ARG GLN ARG THR PRO LYS ILE ASN MET MET LEU ALA ASN          
SEQRES  12 Y  565  LEU TYR LYS LYS ALA GLY GLN GLU ARG PRO SER VAL THR          
SEQRES  13 Y  565  SER TYR LYS GLU VAL LEU ARG GLN CYS PRO LEU ALA LEU          
SEQRES  14 Y  565  ASP ALA ILE LEU GLY LEU LEU SER LEU SER VAL LYS GLY          
SEQRES  15 Y  565  ALA GLU VAL ALA SER MET THR MET ASN VAL ILE GLN THR          
SEQRES  16 Y  565  VAL PRO ASN LEU ASP TRP LEU SER VAL TRP ILE LYS ALA          
SEQRES  17 Y  565  TYR ALA PHE VAL HIS THR GLY ASP ASN SER ARG ALA ILE          
SEQRES  18 Y  565  SER THR ILE CYS SER LEU GLU LYS LYS SER LEU LEU ARG          
SEQRES  19 Y  565  ASP ASN VAL ASP LEU LEU GLY SER LEU ALA ASP LEU TYR          
SEQRES  20 Y  565  PHE ARG ALA GLY ASP ASN LYS ASN SER VAL LEU LYS PHE          
SEQRES  21 Y  565  GLU GLN ALA GLN MET LEU ASP PRO TYR LEU ILE LYS GLY          
SEQRES  22 Y  565  MET ASP VAL TYR GLY TYR LEU LEU ALA ARG GLU GLY ARG          
SEQRES  23 Y  565  LEU GLU ASP VAL GLU ASN LEU GLY CYS ARG LEU PHE ASN          
SEQRES  24 Y  565  ILE SER ASP GLN HIS ALA GLU PRO TRP VAL VAL SER GLY          
SEQRES  25 Y  565  CYS HIS SER PHE TYR SER LYS ARG TYR SER ARG ALA LEU          
SEQRES  26 Y  565  TYR LEU GLY ALA LYS ALA ILE GLN LEU ASN SER ASN SER          
SEQRES  27 Y  565  VAL GLN ALA LEU LEU LEU LYS GLY ALA ALA LEU ARG ASN          
SEQRES  28 Y  565  MET GLY ARG VAL GLN GLU ALA ILE ILE HIS PHE ARG GLU          
SEQRES  29 Y  565  ALA ILE ARG LEU ALA PRO CYS ARG LEU ASP CYS TYR GLU          
SEQRES  30 Y  565  GLY LEU ILE GLU CYS TYR LEU ALA SER ASN SER ILE ARG          
SEQRES  31 Y  565  GLU ALA MET VAL MET ALA ASN ASN VAL TYR LYS THR LEU          
SEQRES  32 Y  565  GLY ALA ASN ALA GLN THR LEU THR LEU LEU ALA THR VAL          
SEQRES  33 Y  565  CYS LEU GLU ASP PRO VAL THR GLN GLU LYS ALA LYS THR          
SEQRES  34 Y  565  LEU LEU ASN LYS ALA LEU THR GLN GLU PRO ASP TYR ILE          
SEQRES  35 Y  565  LYS ALA VAL VAL LYS LYS ALA GLU LEU LEU SER ARG GLU          
SEQRES  36 Y  565  GLN LYS TYR GLU ASP GLY ILE ALA LEU LEU ARG ASN ALA          
SEQRES  37 Y  565  LEU ALA ASN GLN SER ASP CYS VAL LEU HIS ARG ILE LEU          
SEQRES  38 Y  565  GLY ASP PHE LEU VAL ALA VAL ASN GLU TYR GLN GLU ALA          
SEQRES  39 Y  565  MET ASP GLN TYR SER ILE ALA LEU SER LEU ASP PRO ASN          
SEQRES  40 Y  565  ASP GLN LYS SER LEU GLU GLY MET GLN LYS MET GLU LYS          
SEQRES  41 Y  565  GLU GLU SER PRO THR ASP ALA THR GLN GLU GLU ASP VAL          
SEQRES  42 Y  565  ASP ASP MET GLU GLY SER GLY GLU GLU GLY ASP LEU GLU          
SEQRES  43 Y  565  GLY SER ASP SER GLU ALA ALA GLN TRP ALA ASP GLN GLU          
SEQRES  44 Y  565  GLN TRP PHE GLY MET GLN                                      
HET     ZN  B 101       1                                                       
HET     ZN  B 102       1                                                       
HET     ZN  B 103       1                                                       
HET     ZN  S 601       1                                                       
HET     ZN  S 602       1                                                       
HETNAM      ZN ZINC ION                                                         
FORMUL  24   ZN    5(ZN 2+)                                                     
HELIX    1   1 PRO A   22  HIS A   31  1                                  10    
HELIX    2   2 LYS A  284  ASN A  294  1                                  11    
HELIX    3   3 SER A  615  LEU A  629  1                                  15    
HELIX    4   4 LYS A  631  ALA A  647  1                                  17    
HELIX    5   5 SER A  655  MET A  667  1                                  13    
HELIX    6   6 HIS A  758  THR A  777  1                                  20    
HELIX    7   7 GLU A  781  LYS A  798  1                                  18    
HELIX    8   8 GLY A  800  TYR A  810  1                                  11    
HELIX    9   9 SER A  843  GLY A  854  1                                  12    
HELIX   10  10 CYS A  867  LEU A  882  1                                  16    
HELIX   11  11 SER A  924  VAL A  937  1                                  14    
HELIX   12  12 ARG A  942  THR A  946  5                                   5    
HELIX   13  13 PRO A  948  GLN A  965  1                                  18    
HELIX   14  14 PRO A  971  ILE A  978  1                                   8    
HELIX   15  15 ARG A  980  SER A  984  5                                   5    
HELIX   16  16 ASN A 1020  TRP A 1028  1                                   9    
HELIX   17  17 LEU A 1032  LEU A 1041  1                                  10    
HELIX   18  18 SER A 1058  THR A 1088  1                                  31    
HELIX   19  19 THR A 1132  LYS A 1146  1                                  15    
HELIX   20  20 ASP A 1154  ASN A 1161  1                                   8    
HELIX   21  21 LEU A 1168  GLY A 1183  1                                  16    
HELIX   22  22 HIS A 1184  LEU A 1188  5                                   5    
HELIX   23  23 ALA A 1189  GLY A 1200  1                                  12    
HELIX   24  24 HIS A 1201  LEU A 1217  1                                  17    
HELIX   25  25 ASP A 1221  ILE A 1232  1                                  12    
HELIX   26  26 PRO A 1246  TYR A 1261  1                                  16    
HELIX   27  27 HIS A 1266  GLY A 1278  1                                  13    
HELIX   28  28 ASP A 1290  LEU A 1307  1                                  18    
HELIX   29  29 ASN A 1320  GLY A 1331  1                                  12    
HELIX   30  30 ASN A 1359  TYR A 1375  1                                  17    
HELIX   31  31 ASN A 1380  LEU A 1387  1                                   8    
HELIX   32  32 THR A 1392  VAL A 1399  1                                   8    
HELIX   33  33 LYS A 1400  LEU A 1415  1                                  16    
HELIX   34  34 ASN A 1422  VAL A 1430  1                                   9    
HELIX   35  35 PRO A 1431  ASN A 1437  1                                   7    
HELIX   36  36 ASN A 1453  PHE A 1476  1                                  24    
HELIX   37  37 ASN A 1481  SER A 1500  1                                  20    
HELIX   38  38 ASN A 1503  GLY A 1508  1                                   6    
HELIX   39  39 GLY A 1508  MET A 1527  1                                  20    
HELIX   40  40 ASN A 1532  THR A 1546  1                                  15    
HELIX   41  41 ASN A 1551  PHE A 1566  1                                  16    
HELIX   42  42 ASN A 1578  LEU A 1588  1                                  11    
HELIX   43  43 LEU A 1603  HIS A 1608  5                                   6    
HELIX   44  44 LEU A 1609  ALA A 1613  1                                   5    
HELIX   45  45 THR A 1684  LYS A 1693  1                                  10    
HELIX   46  46 ASP A 1747  CYS A 1758  1                                  12    
HELIX   47  47 LYS A 1767  GLN A 1784  1                                  18    
HELIX   48  48 GLU A 1788  ARG A 1806  1                                  19    
HELIX   49  49 THR A 1811  SER A 1825  1                                  15    
HELIX   50  50 PHE A 1847  GLY A 1866  1                                  20    
HELIX   51  51 GLY A 1867  SER A 1876  1                                  10    
HELIX   52  52 LEU A 1881  SER A 1896  1                                  16    
HELIX   53  53 SER A 1911  PHE A 1921  1                                  11    
HELIX   54  54 LYS A 1925  ALA A 1935  1                                  11    
HELIX   55  55 MET B   57  GLN B   68  1                                  12    
HELIX   56  56 ASP C   28  GLY C   47  1                                  20    
HELIX   57  57 LEU C   48  LEU C   62  1                                  15    
HELIX   58  58 THR C   77  LYS C   97  1                                  21    
HELIX   59  59 GLU C   98  HIS C  107  1                                  10    
HELIX   60  60 SER C  111  SER C  137  1                                  27    
HELIX   61  61 ALA C  150  ARG C  165  1                                  16    
HELIX   62  62 GLY C  169  LEU C  182  1                                  14    
HELIX   63  63 LEU C  184  LEU C  199  1                                  16    
HELIX   64  64 HIS C  202  ILE C  213  1                                  12    
HELIX   65  65 ASP C  215  LEU C  222  1                                   8    
HELIX   66  66 TRP C  228  GLN C  242  1                                  15    
HELIX   67  67 LEU C  243  VAL C  257  1                                  15    
HELIX   68  68 SER C  262  ARG C  277  1                                  16    
HELIX   69  69 ASP C  278  ASP C  293  1                                  16    
HELIX   70  70 ASN C  299  ARG C  310  1                                  12    
HELIX   71  71 MET C  312  ASP C  327  1                                  16    
HELIX   72  72 ARG C  330  SER C  345  1                                  16    
HELIX   73  73 GLN C  346  ASN C  361  1                                  16    
HELIX   74  74 LEU C  365  MET C  378  1                                  14    
HELIX   75  75 ASN C  380  ASN C  395  1                                  16    
HELIX   76  76 ASP C  398  LEU C  412  1                                  15    
HELIX   77  77 MET C  414  ARG C  429  1                                  16    
HELIX   78  78 ASP C  432  ASN C  447  1                                  16    
HELIX   79  79 GLN C  448  GLY C  463  1                                  16    
HELIX   80  80 MET C  468  LEU C  480  1                                  13    
HELIX   81  81 SER C  483  CYS C  500  1                                  18    
HELIX   82  82 GLU C  509  CYS C  523  1                                  15    
HELIX   83  83 LEU C  525  ASN C  540  1                                  16    
HELIX   84  84 ARG C  543  ARG C  557  1                                  15    
HELIX   85  85 VAL D   25  GLU D   46  1                                  22    
HELIX   86  86 ARG E   52  ASP E   92  1                                  41    
HELIX   87  87 PRO E   98  LEU E  103  1                                   6    
HELIX   88  88 GLU F    6  HIS F   18  1                                  13    
HELIX   89  89 ALA F   20  HIS F   36  1                                  17    
HELIX   90  90 SER F   37  SER F   51  1                                  15    
HELIX   91  91 LYS F   53  HIS F   64  1                                  12    
HELIX   92  92 THR F   68  LEU F   82  1                                  15    
HELIX   93  93 LYS F   84  GLY F   94  1                                  11    
HELIX   94  94 HIS F  103  GLY F  111  1                                   9    
HELIX   95  95 SER F  113  ASP F  129  1                                  17    
HELIX   96  96 ARG F  130  ASN F  145  1                                  16    
HELIX   97  97 LEU F  148  ILE F  158  1                                  11    
HELIX   98  98 ALA F  451  TYR F  479  1                                  29    
HELIX   99  99 ASN F  480  HIS F  490  1                                  11    
HELIX  100 100 THR F  498  LEU F  512  1                                  15    
HELIX  101 101 GLU F  514  GLU F  529  1                                  16    
HELIX  102 102 GLY F  535  GLN F  547  1                                  13    
HELIX  103 103 LYS F  548  ASP F  563  1                                  16    
HELIX  104 104 SER F  566  GLN F  580  1                                  15    
HELIX  105 105 GLU F  582  ASP F  597  1                                  16    
HELIX  106 106 TYR F  600  GLU F  615  1                                  16    
HELIX  107 107 GLU F  616  ASN F  631  1                                  16    
HELIX  108 108 HIS F  634  GLN F  648  1                                  15    
HELIX  109 109 LYS F  650  ASN F  665  1                                  16    
HELIX  110 110 SER F  668  LYS F  683  1                                  16    
HELIX  111 111 LYS F  684  ASP F  699  1                                  16    
HELIX  112 112 ASN F  702  ASN F  716  1                                  15    
HELIX  113 113 LYS F  718  VAL F  733  1                                  16    
HELIX  114 114 GLU F  736  GLY F  751  1                                  16    
HELIX  115 115 GLN F  752  ASP F  767  1                                  16    
HELIX  116 116 LYS F  769  ARG F  819  1                                  14    
HELIX  117 117 LYS G   12  ASP G   25  1                                  14    
HELIX  118 118 GLU H    6  HIS H   18  1                                  13    
HELIX  119 119 ALA H   20  HIS H   36  1                                  17    
HELIX  120 120 SER H   37  SER H   51  1                                  15    
HELIX  121 121 LYS H   53  HIS H   64  1                                  12    
HELIX  122 122 THR H   68  LEU H   82  1                                  15    
HELIX  123 123 LYS H   84  GLY H   94  1                                  11    
HELIX  124 124 HIS H  103  GLY H  111  1                                   9    
HELIX  125 125 SER H  113  ASP H  129  1                                  17    
HELIX  126 126 ARG H  130  ASN H  145  1                                  16    
HELIX  127 127 LEU H  148  ILE H  158  1                                  11    
HELIX  128 128 ASP H  163  LYS H  169  1                                   7    
HELIX  129 129 ALA H  451  TYR H  479  1                                  29    
HELIX  130 130 ASN H  480  HIS H  490  1                                  11    
HELIX  131 131 THR H  498  LEU H  512  1                                  15    
HELIX  132 132 GLU H  514  GLU H  529  1                                  16    
HELIX  133 133 GLY H  535  GLN H  547  1                                  13    
HELIX  134 134 LYS H  548  ASP H  563  1                                  16    
HELIX  135 135 SER H  566  GLN H  580  1                                  15    
HELIX  136 136 GLU H  582  ASP H  597  1                                  16    
HELIX  137 137 TYR H  600  GLU H  615  1                                  16    
HELIX  138 138 GLU H  616  ASN H  631  1                                  16    
HELIX  139 139 HIS H  634  GLN H  648  1                                  15    
HELIX  140 140 LYS H  650  ASN H  665  1                                  16    
HELIX  141 141 SER H  668  LYS H  683  1                                  16    
HELIX  142 142 LYS H  684  ASP H  699  1                                  16    
HELIX  143 143 ASN H  702  ASN H  716  1                                  15    
HELIX  144 144 LYS H  718  VAL H  733  1                                  16    
HELIX  145 145 GLU H  736  GLY H  751  1                                  16    
HELIX  146 146 GLN H  752  ASP H  771  1                                  16    
HELIX  147 147 LEU I   49  PHE I   52  5                                   4    
HELIX  148 148 GLU I  132  LEU I  137  1                                   6    
HELIX  149 149 GLU I  163  ASP I  170  1                                   8    
HELIX  150 150 TYR I  190  MET I  192  5                                   3    
HELIX  151 151 THR I  238  PHE I  244  1                                   7    
HELIX  152 152 PHE I  244  LYS I  294  1                                  51    
HELIX  153 153 SER I  299  TRP I  310  1                                  12    
HELIX  154 154 ALA I  315  LEU I  325  1                                  11    
HELIX  155 155 THR I  326  HIS I  351  1                                  26    
HELIX  156 156 HIS I  351  TRP I  372  1                                  22    
HELIX  157 157 TRP I  372  GLU I  377  1                                   6    
HELIX  158 158 ASP I  382  THR I  429  1                                  48    
HELIX  159 159 THR I  441  PHE I  456  1                                  16    
HELIX  160 160 ARG I  474  ASP I  481  1                                   8    
HELIX  161 161 ASN I  495  ASN I  503  1                                   9    
HELIX  162 162 SER I  505  SER I  510  1                                   6    
HELIX  163 163 SER I  521  MET I  548  1                                  28    
HELIX  164 164 SER I  672  VAL I  674  5                                   3    
HELIX  165 165 ASP I  679  TYR I  683  5                                   5    
HELIX  166 166 ASN J    2  GLN J   17  1                                  16    
HELIX  167 167 GLN J   18  ARG J   34  1                                  17    
HELIX  168 168 GLU J   36  THR J   50  1                                  15    
HELIX  169 169 GLN J   52  ARG J   63  1                                  12    
HELIX  170 170 LYS J   64  GLU J   70  1                                   7    
HELIX  171 171 GLU J   70  LYS J   84  1                                  15    
HELIX  172 172 GLN J   87  ASP J   94  1                                   8    
HELIX  173 173 SER J  124  ASP J  144  1                                  21    
HELIX  174 174 ASN J  145  VAL J  161  1                                  17    
HELIX  175 175 CYS J  163  HIS J  173  1                                  11    
HELIX  176 176 THR J  177  LEU J  188  1                                  12    
HELIX  177 177 CYS J  194  LEU J  209  1                                  16    
HELIX  178 178 ASN J  230  CYS J  245  1                                  16    
HELIX  179 179 ASP J  246  ASP J  261  1                                  16    
HELIX  180 180 SER J  266  LEU J  278  1                                  13    
HELIX  181 181 LYS J  280  TYR J  295  1                                  16    
HELIX  182 182 ASN J  298  GLY J  313  1                                  16    
HELIX  183 183 LYS J  315  GLU J  330  1                                  16    
HELIX  184 184 TYR J  333  SER J  348  1                                  16    
HELIX  185 185 GLU J  349  MET J  364  1                                  16    
HELIX  186 186 HIS J  368  THR J  381  1                                  14    
HELIX  187 187 ASN J  383  ILE J  397  1                                  15    
HELIX  188 188 ASP J  401  GLY J  416  1                                  16    
HELIX  189 189 TRP J  418  ALA J  434  1                                  17    
HELIX  190 190 TRP J  444  LEU J  458  1                                  15    
HELIX  191 191 LYS J  460  ILE J  475  1                                  16    
HELIX  192 192 ASN J  478  MET J  492  1                                  15    
HELIX  193 193 ASN J  494  ARG J  509  1                                  16    
HELIX  194 194 ASP J  512  ASP J  529  1                                  18    
HELIX  195 195 ASN K    2  GLN K   17  1                                  16    
HELIX  196 196 GLN K   18  ARG K   34  1                                  17    
HELIX  197 197 GLU K   36  THR K   50  1                                  15    
HELIX  198 198 GLN K   52  SER K   62  1                                  11    
HELIX  199 199 LYS K   64  TYR K   69  1                                   6    
HELIX  200 200 TYR K   69  ALA K   83  1                                  15    
HELIX  201 201 GLN K   87  LEU K   93  1                                   7    
HELIX  202 202 ILE K  128  ASP K  144  1                                  17    
HELIX  203 203 ASN K  145  VAL K  161  1                                  17    
HELIX  204 204 CYS K  163  SER K  172  1                                  10    
HELIX  205 205 HIS K  173  MET K  175  5                                   3    
HELIX  206 206 ALA K  178  LEU K  188  1                                  11    
HELIX  207 207 CYS K  194  LYS K  211  1                                  18    
HELIX  208 208 THR K  218  ASP K  225  1                                   8    
HELIX  209 209 GLY K  226  LYS K  229  5                                   4    
HELIX  210 210 ASN K  230  CYS K  245  1                                  16    
HELIX  211 211 ASP K  246  ASP K  261  1                                  16    
HELIX  212 212 SER K  266  LEU K  278  1                                  13    
HELIX  213 213 LYS K  280  TYR K  295  1                                  16    
HELIX  214 214 ASN K  298  GLY K  313  1                                  16    
HELIX  215 215 LYS K  315  GLU K  330  1                                  16    
HELIX  216 216 GLY K  334  SER K  348  1                                  15    
HELIX  217 217 GLU K  349  MET K  364  1                                  16    
HELIX  218 218 HIS K  368  THR K  381  1                                  14    
HELIX  219 219 ASN K  383  ALA K  398  1                                  16    
HELIX  220 220 ASP K  401  GLY K  416  1                                  16    
HELIX  221 221 GLU K  417  ILE K  435  1                                  19    
HELIX  222 222 THR K  440  LEU K  458  1                                  19    
HELIX  223 223 LYS K  460  ILE K  475  1                                  16    
HELIX  224 224 ASN K  478  MET K  492  1                                  15    
HELIX  225 225 ASN K  494  ARG K  509  1                                  16    
HELIX  226 226 ASP K  512  ILE K  527  1                                  16    
HELIX  227 227 ASP L   12  GLY L   20  1                                   9    
HELIX  228 228 GLY L   41  ARG L   46  1                                   6    
HELIX  229 229 HIS L  145  GLY L  148  5                                   4    
HELIX  230 230 THR L  174  SER L  182  1                                   9    
HELIX  231 231 ASP M    8  ASP M   16  1                                   9    
HELIX  232 232 SER M   49  LYS M   56  1                                   8    
HELIX  233 233 ARG N   15  THR N   29  1                                  15    
HELIX  234 234 GLU N   53  ARG N   63  1                                  11    
HELIX  235 235 LEU N   79  TRP N   92  1                                  14    
HELIX  236 236 ASN N   93  GLU N   99  1                                   7    
HELIX  237 237 CYS N  107  ASP N  123  1                                  17    
HELIX  238 238 ASP N  123  GLY N  139  1                                  17    
HELIX  239 239 LEU N  149  PHE N  162  1                                  14    
HELIX  240 240 PRO N  166  GLY N  191  1                                  26    
HELIX  241 241 LEU N  203  LEU N  215  1                                  13    
HELIX  242 242 ARG N  234  LEU N  250  1                                  17    
HELIX  243 243 LEU N  252  ARG N  278  1                                  27    
HELIX  244 244 ARG N  287  PHE N  304  1                                  18    
HELIX  245 245 TRP N  324  ARG N  349  1                                  26    
HELIX  246 246 SER N  354  ARG N  367  1                                  14    
HELIX  247 247 GLN N  370  LEU N  386  1                                  17    
HELIX  248 248 ASP N  395  VAL N  409  1                                  15    
HELIX  249 249 MET N  414  CYS N  421  1                                   8    
HELIX  250 250 CYS N  421  GLU N  432  1                                  12    
HELIX  251 251 ASP N  433  LEU N  442  1                                  10    
HELIX  252 252 ASP N  451  LYS N  458  1                                   8    
HELIX  253 253 SER N  499  GLY N  510  1                                  12    
HELIX  254 254 LYS N  512  GLN N  530  1                                  19    
HELIX  255 255 GLU N  536  PHE N  549  1                                  14    
HELIX  256 256 MET N  554  ASP N  563  1                                  10    
HELIX  257 257 MET N  564  LYS N  580  1                                  17    
HELIX  258 258 ARG N  581  GLU N  584  5                                   4    
HELIX  259 259 PRO N  612  LEU N  629  1                                  18    
HELIX  260 260 LYS N  638  GLY N  642  5                                   5    
HELIX  261 261 THR N  660  ASP N  672  1                                  13    
HELIX  262 262 THR N  677  LYS N  686  1                                  10    
HELIX  263 263 PRO N  688  GLY N  703  1                                  16    
HELIX  264 264 THR O   31  SER O   45  1                                  15    
HELIX  265 265 SER O   53  GLY O   70  1                                  18    
HELIX  266 266 THR O   74  CYS O   86  1                                  13    
HELIX  267 267 GLN O   88  GLY O  103  1                                  16    
HELIX  268 268 GLU O  104  GLY O  121  1                                  18    
HELIX  269 269 THR O  129  LEU O  146  1                                  18    
HELIX  270 270 SER O  147  LYS O  169  1                                  23    
HELIX  271 271 SER O  208  ASP O  226  1                                  19    
HELIX  272 272 THR O  232  ASN O  247  1                                  16    
HELIX  273 273 ALA O  251  GLN O  265  1                                  15    
HELIX  274 274 ASP O  266  LEU O  281  1                                  16    
HELIX  275 275 GLY O  297  PHE O  314  1                                  18    
HELIX  276 276 HIS O  316  ASN O  335  1                                  20    
HELIX  277 277 ASP O  336  GLY O  351  1                                  16    
HELIX  278 278 SER O  357  HIS O  370  1                                  14    
HELIX  279 279 LEU O  373  GLY O  392  1                                  20    
HELIX  280 280 THR O  394  SER O  413  1                                  20    
HELIX  281 281 LEU O  414  TYR O  432  1                                  19    
HELIX  282 282 ARG O  434  MET O  448  1                                  15    
HELIX  283 283 ASN O  462  GLN O  480  1                                  19    
HELIX  284 284 CYS O  482  PHE O  497  1                                  16    
HELIX  285 285 HIS O  503  GLY O  523  1                                  21    
HELIX  286 286 LYS O  524  SER O  540  1                                  17    
HELIX  287 287 SER O  540  ASN O  555  1                                  16    
HELIX  288 288 GLN O  556  LYS O  575  1                                  20    
HELIX  289 289 ASN O  576  SER O  594  1                                  19    
HELIX  290 290 SER O  596  THR O  598  5                                   3    
HELIX  291 291 ILE O  599  TYR O  614  1                                  16    
HELIX  292 292 LEU O  616  LEU O  634  1                                  19    
HELIX  293 293 ILE O  636  ASP O  654  1                                  19    
HELIX  294 294 ILE O  657  TYR O  678  1                                  22    
HELIX  295 295 LYS O  682  ASP O  705  1                                  24    
HELIX  296 296 LYS O  707  GLY O  725  1                                  19    
HELIX  297 297 LYS O  726  HIS O  741  1                                  16    
HELIX  298 298 ASP P   28  GLY P   47  1                                  20    
HELIX  299 299 LEU P   48  LEU P   62  1                                  15    
HELIX  300 300 THR P   77  LYS P   97  1                                  21    
HELIX  301 301 GLU P   98  HIS P  107  1                                  10    
HELIX  302 302 SER P  111  THR P  134  1                                  24    
HELIX  303 303 ASN P  148  ARG P  165  1                                  18    
HELIX  304 304 GLY P  169  LEU P  182  1                                  14    
HELIX  305 305 LEU P  184  LEU P  199  1                                  16    
HELIX  306 306 HIS P  202  ILE P  213  1                                  12    
HELIX  307 307 ASP P  215  LEU P  222  1                                   8    
HELIX  308 308 TRP P  228  LEU P  241  1                                  14    
HELIX  309 309 LEU P  243  VAL P  257  1                                  15    
HELIX  310 310 SER P  262  ILE P  276  1                                  15    
HELIX  311 311 ASP P  278  ASP P  293  1                                  16    
HELIX  312 312 ASN P  299  ARG P  310  1                                  12    
HELIX  313 313 MET P  312  ASP P  327  1                                  16    
HELIX  314 314 ARG P  330  SER P  345  1                                  16    
HELIX  315 315 GLN P  346  ASN P  361  1                                  16    
HELIX  316 316 TYR P  364  MET P  378  1                                  15    
HELIX  317 317 ASN P  380  ASN P  395  1                                  16    
HELIX  318 318 ASP P  398  LEU P  412  1                                  15    
HELIX  319 319 PRO P  415  ARG P  429  1                                  15    
HELIX  320 320 ASP P  432  ASN P  447  1                                  16    
HELIX  321 321 GLN P  448  GLY P  463  1                                  16    
HELIX  322 322 MET P  468  LEU P  480  1                                  13    
HELIX  323 323 GLU P  482  CYS P  500  1                                  19    
HELIX  324 324 THR P  511  CYS P  523  1                                  13    
HELIX  325 325 LEU P  525  ALA P  538  1                                  14    
HELIX  326 326 ASN R   56  ARG R   63  1                                   8    
HELIX  327 327 GLY R   88  LEU R  100  1                                  13    
HELIX  328 328 SER R  154  SER R  163  1                                  10    
HELIX  329 329 ARG S  358  ALA S  366  1                                   9    
HELIX  330 330 LYS S  423  GLY S  432  1                                  10    
HELIX  331 331 SER U    6  ALA U   21  1                                  16    
HELIX  332 332 LYS W   12  ASP W   25  1                                  14    
HELIX  333 333 ASN X   36  GLY X   48  1                                  13    
HELIX  334 334 LEU X   49  ASN X   67  1                                  19    
HELIX  335 335 SER X   72  ASP X   90  1                                  19    
HELIX  336 336 GLU X   92  LEU X  110  1                                  19    
HELIX  337 337 SER X  134  LYS X  150  1                                  17    
HELIX  338 338 GLN X  151  GLY X  161  1                                  11    
HELIX  339 339 THR X  168  GLY X  183  1                                  16    
HELIX  340 340 GLN X  184  CYS X  199  1                                  16    
HELIX  341 341 ALA X  202  SER X  213  1                                  12    
HELIX  342 342 VAL X  214  THR X  229  1                                  16    
HELIX  343 343 TRP X  235  GLY X  249  1                                  15    
HELIX  344 344 ASP X  250  LYS X  264  1                                  15    
HELIX  345 345 ASN X  270  GLY X  285  1                                  16    
HELIX  346 346 ASP X  286  ASP X  301  1                                  16    
HELIX  347 347 LEU X  304  GLY X  319  1                                  16    
HELIX  348 348 ARG X  320  SER X  335  1                                  16    
HELIX  349 349 HIS X  338  LYS X  353  1                                  16    
HELIX  350 350 ARG X  354  ASN X  369  1                                  16    
HELIX  351 351 VAL X  373  GLY X  387  1                                  15    
HELIX  352 352 ARG X  388  ALA X  403  1                                  16    
HELIX  353 353 ARG X  406  ASN X  421  1                                  16    
HELIX  354 354 SER X  422  GLY X  438  1                                  17    
HELIX  355 355 ALA X  441  ASP X  454  1                                  14    
HELIX  356 356 THR X  457  GLU X  472  1                                  16    
HELIX  357 357 TYR X  475  GLN X  490  1                                  16    
HELIX  358 358 LYS X  491  GLN X  506  1                                  16    
HELIX  359 359 CYS X  509  ASN X  523  1                                  15    
HELIX  360 360 GLU X  524  ASP X  539  1                                  16    
HELIX  361 361 ASN Y   36  GLY Y   48  1                                  13    
HELIX  362 362 LEU Y   49  ASN Y   67  1                                  19    
HELIX  363 363 SER Y   72  ASP Y   90  1                                  19    
HELIX  364 364 GLU Y   92  LEU Y  110  1                                  19    
HELIX  365 365 SER Y  134  LYS Y  150  1                                  17    
HELIX  366 366 GLN Y  151  ILE Y  162  1                                  12    
HELIX  367 367 THR Y  168  GLY Y  183  1                                  16    
HELIX  368 368 GLN Y  184  CYS Y  199  1                                  16    
HELIX  369 369 ALA Y  202  SER Y  213  1                                  12    
HELIX  370 370 VAL Y  214  THR Y  229  1                                  16    
HELIX  371 371 TRP Y  235  GLY Y  249  1                                  15    
HELIX  372 372 ASP Y  250  LYS Y  264  1                                  15    
HELIX  373 373 ASN Y  270  GLY Y  285  1                                  16    
HELIX  374 374 ASP Y  286  ASP Y  301  1                                  16    
HELIX  375 375 LEU Y  304  GLY Y  319  1                                  16    
HELIX  376 376 ARG Y  320  SER Y  335  1                                  16    
HELIX  377 377 HIS Y  338  LYS Y  353  1                                  16    
HELIX  378 378 ARG Y  354  ASN Y  369  1                                  16    
HELIX  379 379 SER Y  372  GLY Y  387  1                                  16    
HELIX  380 380 ARG Y  388  ALA Y  403  1                                  16    
HELIX  381 381 ARG Y  406  ASN Y  421  1                                  16    
HELIX  382 382 SER Y  422  GLY Y  438  1                                  17    
HELIX  383 383 ALA Y  441  ASP Y  454  1                                  14    
HELIX  384 384 THR Y  457  GLU Y  472  1                                  16    
HELIX  385 385 TYR Y  475  GLN Y  490  1                                  16    
HELIX  386 386 LYS Y  491  GLN Y  506  1                                  16    
HELIX  387 387 CYS Y  509  ASN Y  523  1                                  15    
HELIX  388 388 GLU Y  524  ASP Y  539  1                                  16    
HELIX  389 389 ASP Y  542  MET Y  552  1                                  11    
SHEET    1  AA 4 LEU A  17  GLU A  19  0                                        
SHEET    2  AA 4 MET A 604  THR A 608 -1  O  ARG A 606   N  GLN A  18           
SHEET    3  AA 4 ARG A 594  LEU A 599 -1  O  VAL A 595   N  ILE A 607           
SHEET    4  AA 4 ILE A 584  VAL A 591 -1  N  HIS A 585   O  GLU A 598           
SHEET    1  AB 4 SER A  73  LYS A  78  0                                        
SHEET    2  AB 4 ASP A  90  VAL A  95 -1  O  GLU A  91   N  ARG A  77           
SHEET    3  AB 4 MET A  99  SER A 103 -1  O  ILE A 101   N  TYR A  94           
SHEET    4  AB 4 LYS A 115  THR A 118 -1  O  LYS A 115   N  TRP A 102           
SHEET    1  AC 4 LEU A 127  ILE A 132  0                                        
SHEET    2  AC 4 VAL A 147  LEU A 154 -1  O  GLU A 148   N  PHE A 131           
SHEET    3  AC 4 ILE A 159  SER A 163 -1  O  ASN A 160   N  ILE A 153           
SHEET    4  AC 4 ASP A 168  ILE A 170 -1  O  TYR A 169   N  MET A 161           
SHEET    1  AD 4 VAL A 177  VAL A 180  0                                        
SHEET    2  AD 4 LEU A 187  ARG A 191 -1  O  GLU A 190   N  ALA A 178           
SHEET    3  AD 4 MET A 210  MET A 213 -1  O  PHE A 211   N  PHE A 189           
SHEET    4  AD 4 THR A 221  PRO A 222 -1  O  THR A 221   N  SER A 212           
SHEET    1  AE 4 LYS A 245  ASN A 250  0                                        
SHEET    2  AE 4 ILE A 255  ASP A 260 -1  O  ILE A 255   N  ASN A 250           
SHEET    3  AE 4 VAL A 265  TRP A 269 -1  O  VAL A 265   N  ASP A 260           
SHEET    4  AE 4 HIS A 411  TRP A 413 -1  N  LEU A 412   O  VAL A 268           
SHEET    1  AF 4 VAL A 430  SER A 434  0                                        
SHEET    2  AF 4 LYS A 440  VAL A 446 -1  O  PHE A 441   N  THR A 433           
SHEET    3  AF 4 GLN A 451  GLU A 459 -1  O  GLN A 451   N  VAL A 446           
SHEET    4  AF 4 LEU A 466  ILE A 474 -1  O  ILE A 467   N  GLN A 458           
SHEET    1  AG 4 ASP A 478  VAL A 482  0                                        
SHEET    2  AG 4 THR A 487  GLU A 492 -1  O  THR A 487   N  VAL A 482           
SHEET    3  AG 4 ASN A 496  TYR A 500 -1  O  ASN A 496   N  GLU A 492           
SHEET    4  AG 4 ARG A 505  LYS A 508 -1  N  VAL A 506   O  LEU A 499           
SHEET    1  AH 2 THR A1108  ALA A1111  0                                        
SHEET    2  AH 2 THR A1116  ASP A1119 -1  O  THR A1116   N  ALA A1111           
SHEET    1  AI 2 TYR A1572  LEU A1574  0                                        
SHEET    2  AI 2 ALA A1614  PRO A1616 -1  O  GLU A1615   N  SER A1573           
SHEET    1  AJ 2 VAL A1620  VAL A1622  0                                        
SHEET    2  AJ 2 VAL A1696  TYR A1698  1  O  LEU A1697   N  VAL A1622           
SHEET    1  AK 4 GLN A1646  MET A1652  0                                        
SHEET    2  AK 4 LEU A1633  LYS A1639 -1  O  LEU A1634   N  LEU A1651           
SHEET    3  AK 4 LEU A1663  VAL A1668 -1  N  LYS A1664   O  LEU A1637           
SHEET    4  AK 4 GLU A1675  ILE A1678 -1  O  GLU A1675   N  VAL A1668           
SHEET    1  BA 3 VAL B   3  ASN B   9  0                                        
SHEET    2  BA 3 LEU N 643  VAL N 648 -1  O  LEU N 643   N  ASN B   9           
SHEET    3  BA 3 LEU N 655  SER N 656 -1  O  LEU N 655   N  VAL N 648           
SHEET    1  BB 2 LEU B  46  TRP B  48  0                                        
SHEET    2  BB 2 CYS B  54  HIS B  56 -1  O  PHE B  55   N  VAL B  47           
SHEET    1  IA 4 ILE I  23  TRP I  28  0                                        
SHEET    2  IA 4 ILE I  35  ASN I  39 -1  O  ALA I  36   N  VAL I  27           
SHEET    3  IA 4 VAL I  44  HIS I  47 -1  O  LEU I  45   N  LEU I  37           
SHEET    4  IA 4 ARG I  54  PHE I  58 -1  N  VAL I  55   O  LEU I  46           
SHEET    1  IB 4 VAL I  68  TRP I  73  0                                        
SHEET    2  IB 4 LEU I  79  LEU I  84 -1  O  ALA I  81   N  ALA I  72           
SHEET    3  IB 4 ILE I  90  ASP I  94 -1  O  VAL I  91   N  PHE I  82           
SHEET    4  IB 4 SER I 100  PHE I 104 -1  O  HIS I 102   N  LEU I  92           
SHEET    1  IC 4 CYS I 112  GLU I 117  0                                        
SHEET    2  IC 4 ASN I 174  GLY I 179 -1  O  ILE I 175   N  MET I 116           
SHEET    3  IC 4 PHE I 184  ALA I 189 -1  O  GLU I 186   N  LEU I 178           
SHEET    4  IC 4 PHE I 193  THR I 199 -1  O  PHE I 193   N  ALA I 189           
SHEET    1  ID 4 THR I 204  LEU I 210  0                                        
SHEET    2  ID 4 SER I 216  GLU I 222 -1  O  SER I 218   N  CYS I 209           
SHEET    3  ID 4 TYR I 233  GLU I 237 -1  O  PHE I 234   N  VAL I 219           
SHEET    4  ID 4 ALA I 551  ILE I 554 -1  O  ILE I 552   N  GLN I 235           
SHEET    1  IE 2 SER I 229  GLU I 230  0                                        
SHEET    2  IE 2 ARG I 558  ASP I 559 -1  O  ASP I 559   N  SER I 229           
SHEET    1  IF 5 PHE I 574  ASN I 578  0                                        
SHEET    2  IF 5 LEU I 583  LEU I 591 -1  O  LEU I 583   N  ASN I 578           
SHEET    3  IF 5 TYR I 596  HIS I 604 -1  O  LYS I 597   N  ILE I 590           
SHEET    4  IF 5 LEU I 615  THR I 624 -1  O  ILE I 616   N  ILE I 600           
SHEET    5  IF 5 VAL I 631  ARG I 632 -1  O  ARG I 632   N  PHE I 623           
SHEET    1  IG 5 PHE I 574  ASN I 578  0                                        
SHEET    2  IG 5 LEU I 583  LEU I 591 -1  O  LEU I 583   N  ASN I 578           
SHEET    3  IG 5 TYR I 596  HIS I 604 -1  O  LYS I 597   N  ILE I 590           
SHEET    4  IG 5 LEU I 615  THR I 624 -1  O  ILE I 616   N  ILE I 600           
SHEET    5  IG 5 THR I 702  PHE I 707  1  O  ARG I 703   N  LYS I 619           
SHEET    1  IH 2 VAL I 631  ARG I 632  0                                        
SHEET    2  IH 2 LEU I 615  THR I 624 -1  O  PHE I 623   N  ARG I 632           
SHEET    1  II 4 TYR I 636  ASP I 645  0                                        
SHEET    2  II 4 THR I 648  ASP I 655 -1  O  THR I 648   N  TYR I 644           
SHEET    3  II 4 ARG I 664  PRO I 670 -1  O  LEU I 665   N  LEU I 653           
SHEET    4  II 4 TRP I 711  LEU I 713 -1  O  ARG I 712   N  LEU I 666           
SHEET    1  IJ 3 ALA I 719  GLY I 724  0                                        
SHEET    2  IJ 3 VAL I 730  SER I 735 -1  O  CYS I 732   N  ALA I 723           
SHEET    3  IJ 3 VAL I 741  GLU I 745 -1  O  ARG I 742   N  VAL I 733           
SHEET    1  LA 4 VAL L  22  GLU L  24  0                                        
SHEET    2  LA 4 GLN L 155  PRO L 161 -1  O  THR L 160   N  ARG L  23           
SHEET    3  LA 4 THR L  76  TYR L  80 -1  O  THR L  76   N  TYR L 159           
SHEET    4  LA 4 TRP L 119  PRO L 123 -1  O  ILE L 120   N  ILE L  79           
SHEET    1  LB 5 VAL L  30  LEU L  33  0                                        
SHEET    2  LB 5 HIS L  62  VAL L  74 -1  O  ASN L  65   N  SER L  32           
SHEET    3  LB 5 THR L 132  VAL L 141 -1  O  THR L 132   N  VAL L  74           
SHEET    4  LB 5 LYS L  93  GLY L  99 -1  O  SER L  95   N  ALA L 140           
SHEET    5  LB 5 GLN L 106  GLU L 112 -1  O  GLN L 106   N  VAL L  98           
SHEET    1  RA 4 LYS R 177  ASP R 180  0                                        
SHEET    2  RA 4 THR R 466  ASN R 471 -1  O  LEU R 467   N  LEU R 179           
SHEET    3  RA 4 ALA R 457  ALA R 462 -1  O  ILE R 458   N  TRP R 470           
SHEET    4  RA 4 TYR R 448  MET R 451 -1  O  TYR R 448   N  GLY R 461           
SHEET    1  RB 4 VAL R 193  TRP R 195  0                                        
SHEET    2  RB 4 VAL R 200  LEU R 205 -1  O  SER R 202   N  ASP R 194           
SHEET    3  RB 4 CYS R 208  SER R 213 -1  O  CYS R 208   N  LEU R 205           
SHEET    4  RB 4 VAL R 219  ASP R 224 -1  O  THR R 220   N  LEU R 211           
SHEET    1  RC 4 VAL R 232  TRP R 237  0                                        
SHEET    2  RC 4 LEU R 243  THR R 248 -1  O  ALA R 245   N  GLY R 236           
SHEET    3  RC 4 VAL R 253  ASP R 257 -1  O  GLN R 254   N  VAL R 246           
SHEET    4  RC 4 LYS R 262  LEU R 267 -1  O  LYS R 262   N  ASP R 257           
SHEET    1  RD 4 VAL R 274  ASN R 280  0                                        
SHEET    2  RD 4 GLN R 283  SER R 288 -1  O  GLN R 283   N  ASN R 280           
SHEET    3  RD 4 MET R 292  ASP R 297 -1  O  MET R 292   N  SER R 288           
SHEET    4  RD 4 GLN R 304  LEU R 309 -1  N  SER R 305   O  GLN R 295           
SHEET    1  RE 4 LEU R 319  TRP R 321  0                                        
SHEET    2  RE 4 LEU R 327  GLY R 331 -1  O  ALA R 329   N  LYS R 320           
SHEET    3  RE 4 LEU R 337  ASN R 341 -1  O  LEU R 338   N  SER R 330           
SHEET    4  RE 4 GLN R 349  TYR R 351 -1  O  GLN R 349   N  VAL R 339           
SHEET    1  RF 4 ALA R 360  TRP R 363  0                                        
SHEET    2  RF 4 LEU R 370  GLY R 374 -1  O  ALA R 372   N  ALA R 362           
SHEET    3  RF 4 CYS R 381  ASN R 386 -1  O  ARG R 383   N  SER R 373           
SHEET    4  RF 4 PRO R 392  ASP R 397 -1  N  LEU R 393   O  PHE R 384           
SHEET    1  RG 3 VAL R 402  TRP R 407  0                                        
SHEET    2  RG 3 GLU R 413  HIS R 418 -1  O  VAL R 415   N  ALA R 406           
SHEET    3  RG 3 ILE R 425  LYS R 429 -1  O  LEU R 426   N  SER R 416           
SHEET    1  SA 4 LYS S 376  ALA S 377  0                                        
SHEET    2  SA 4 PRO S 384  ASP S 388 -1  O  ALA S 385   N  LYS S 376           
SHEET    3  SA 4 ARG S 393  CYS S 396 -1  O  ARG S 393   N  ASP S 388           
SHEET    4  SA 4 ASP S 404  CYS S 406 -1  O  TYR S 405   N  ALA S 394           
LINK        ZN    ZN B 101                 SG  CYS B  59     1555   1555  2.68  
LINK        ZN    ZN B 101                 SG  CYS B  23     1555   1555  2.47  
LINK        ZN    ZN B 101                 SG  CYS B  26     1555   1555  2.63  
LINK        ZN    ZN B 102                 SG  CYS B  76     1555   1555  2.76  
LINK        ZN    ZN B 102                 SG  CYS B  73     1555   1555  2.57  
LINK        ZN    ZN B 102                 ND1 HIS B  53     1555   1555  2.55  
CISPEP   1 LEU A 1100    PRO A 1101          0         5.92                     
CISPEP   2 PRO A 1112    PRO A 1113          0         6.13                     
CISPEP   3 GLY A 1670    PRO A 1671          0        -7.37                     
CISPEP   4 SER A 1742    ALA A 1743          0        18.78                     
CISPEP   5 TRP B   14    LEU B   15          0        -0.30                     
CISPEP   6 GLN B   68    VAL B   69          0        -9.34                     
CISPEP   7 VAL C   96    LYS C   97          0        20.16                     
CISPEP   8 ASN C  361    PRO C  362          0       -15.40                     
CISPEP   9 ASN F  145    PRO F  146          0       -22.19                     
CISPEP  10 ASN H  145    PRO H  146          0       -17.65                     
CISPEP  11 PRO I  489    PRO I  490          0        18.23                     
CISPEP  12 PHE I  572    PRO I  573          0         0.57                     
CISPEP  13 GLN L   60    PRO L   61          0         5.33                     
CISPEP  14 THR L  125    ASP L  126          0        -9.49                     
CISPEP  15 PRO L  170    ARG L  171          0        -2.94                     
CISPEP  16 TYR N  125    LEU N  126          0         3.64                     
CISPEP  17 THR N  165    PRO N  166          0       -25.30                     
CISPEP  18 PRO N  197    GLU N  198          0        -3.68                     
CISPEP  19 SER N  284    PHE N  285          0        12.69                     
CISPEP  20 ASP N  350    PHE N  351          0       -26.14                     
CISPEP  21 THR N  368    ASP N  369          0         2.72                     
CISPEP  22 GLU N  478    ASP N  479          0        -4.19                     
CISPEP  23 ASP N  483    PRO N  484          0        28.27                     
CISPEP  24 SER N  493    SER N  494          0       -27.05                     
CISPEP  25 SER N  532    PHE N  533          0       -11.64                     
CISPEP  26 GLY N  550    GLU N  551          0       -16.17                     
CISPEP  27 PRO N  709    PRO N  710          0        -8.11                     
CISPEP  28 GLU O  123    PRO O  124          0        -6.14                     
CISPEP  29 ASP O  356    SER O  357          0         8.09                     
CISPEP  30 VAL P   96    LYS P   97          0        21.63                     
CISPEP  31 ASN P  361    PRO P  362          0       -17.79                     
CISPEP  32 LEU R  127    PHE R  128          0        24.92                     
CISPEP  33 TYR R  420    SER R  421          0       -10.99                     
CISPEP  34 SER R  484    VAL R  485          0       -20.75                     
CISPEP  35 PHE S  321    ARG S  322          0        -1.57                     
CISPEP  36 LEU T    7    ALA T    8          0        -4.19                     
CISPEP  37 ALA T   11    ALA T   12          0         5.45                     
CISPEP  38 CYS Y  199    PRO Y  200          0       -21.23                     
SITE     1 AC1  4 CYS B  23  CYS B  26  HIS B  56  CYS B  59                    
SITE     1 AC2  4 CYS B  51  HIS B  53  CYS B  73  CYS B  76                    
SITE     1 AC3  4 CYS B  34  CYS B  37  CYS B  44  HIS B  58                    
SITE     1 AC4  5 CYS S 378  ARG S 380  CYS S 381  CYS S 396                    
SITE     2 AC4  5 CYS S 401                                                     
SITE     1 AC5  4 CYS S 406  CYS S 409  HIS S 414  CYS S 419                    
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system