HEADER CELL CYCLE 27-MAR-15 4UI9
TITLE ATOMIC STRUCTURE OF THE HUMAN ANAPHASE-PROMOTING COMPLEX
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 1;
COMPND 3 CHAIN: A;
COMPND 4 SYNONYM: APC1, CYCLOSOME SUBUNIT 1, MITOTIC CHECKPOINT REGULATOR,
COMPND 5 TESTIS-SPECIFIC GENE 24 PROTEIN, APC1, CYCLOSOME SUBUNIT 1, MITOTIC
COMPND 6 CHECKPOINT REGULATOR, TESTIS-SPECIFIC GENE 24 PROTEIN;
COMPND 7 MOL_ID: 2;
COMPND 8 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 11;
COMPND 9 CHAIN: B;
COMPND 10 SYNONYM: APC11, CYCLOSOME SUBUNIT 11, HEPATOCELLULAR CARCINOMA-
COMPND 11 ASSOCIATED RING FINGER PROTEIN, APC11, CYCLOSOME SUBUNIT 11,
COMPND 12 HEPATOCELLULAR CARCINOMA- ASSOCIATED RING FINGER PROTEIN;
COMPND 13 MOL_ID: 3;
COMPND 14 MOLECULE: CELL DIVISION CYCLE PROTEIN 23 HOMOLOG;
COMPND 15 CHAIN: C, P;
COMPND 16 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, APC8, CYCLOSOME
COMPND 17 SUBUNIT 8, ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, APC8, CYCLOSOME
COMPND 18 SUBUNIT 8;
COMPND 19 MOL_ID: 4;
COMPND 20 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 15;
COMPND 21 CHAIN: D;
COMPND 22 SYNONYM: APC15, APC15;
COMPND 23 MOL_ID: 5;
COMPND 24 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 16;
COMPND 25 CHAIN: E;
COMPND 26 SYNONYM: APC16, CYCLOSOME SUBUNIT 16, APC16, CYCLOSOME SUBUNIT 16;
COMPND 27 MOL_ID: 6;
COMPND 28 MOLECULE: CELL DIVISION CYCLE PROTEIN 27 HOMOLOG;
COMPND 29 CHAIN: F, H;
COMPND 30 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 3, APC3, CDC27 HOMOLOG,
COMPND 31 CDC27HS, H-NUC, ANAPHASE-PROMOTING COMPLEX SUBUNIT 3, APC3, CDC27
COMPND 32 HOMOLOG, CDC27HS, H-NUC;
COMPND 33 MOL_ID: 7;
COMPND 34 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26;
COMPND 35 CHAIN: G;
COMPND 36 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 12, APC12, CELL DIVISION
COMPND 37 CYCLE PROTEIN 26 HOMOLOG, ANAPHASE-PROMOTING COMPLEX SUBUNIT 12,
COMPND 38 APC12, CELL DIVISION CYCLE PROTEIN 26 HOMOLOG;
COMPND 39 MOL_ID: 8;
COMPND 40 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 4;
COMPND 41 CHAIN: I;
COMPND 42 SYNONYM: APC4, CYCLOSOME SUBUNIT 4, APC4, CYCLOSOME SUBUNIT 4;
COMPND 43 MOL_ID: 9;
COMPND 44 MOLECULE: CELL DIVISION CYCLE PROTEIN 16 HOMOLOG;
COMPND 45 CHAIN: J;
COMPND 46 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 6, APC6, CDC16 HOMOLOG,
COMPND 47 CDC16HS, CYCLOSOME SUBUNIT 6, ANAPHASE-PROMOTING COMPLEX SUBUNIT 6,
COMPND 48 APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6;
COMPND 49 MOL_ID: 10;
COMPND 50 MOLECULE: CELL DIVISION CYCLE PROTEIN 16 HOMOLOG;
COMPND 51 CHAIN: K;
COMPND 52 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 6, APC6, CDC16 HOMOLOG,
COMPND 53 CDC16HS, CYCLOSOME SUBUNIT 6, ANAPHASE-PROMOTING COMPLEX SUBUNIT 6,
COMPND 54 APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6;
COMPND 55 MOL_ID: 11;
COMPND 56 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 10;
COMPND 57 CHAIN: L;
COMPND 58 SYNONYM: APC10, CYCLOSOME SUBUNIT 10, APC10, CYCLOSOME SUBUNIT 10;
COMPND 59 MOL_ID: 12;
COMPND 60 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 13;
COMPND 61 CHAIN: M;
COMPND 62 SYNONYM: APC13, CYCLOSOME SUBUNIT 13, APC13, CYCLOSOME SUBUNIT 13;
COMPND 63 MOL_ID: 13;
COMPND 64 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 2;
COMPND 65 CHAIN: N;
COMPND 66 SYNONYM: APC2, CYCLOSOME SUBUNIT 2, APC2, CYCLOSOME SUBUNIT 2;
COMPND 67 MOL_ID: 14;
COMPND 68 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 5;
COMPND 69 CHAIN: O;
COMPND 70 SYNONYM: APC5, CYCLOSOME SUBUNIT 5, APC5, CYCLOSOME SUBUNIT 5;
COMPND 71 MOL_ID: 15;
COMPND 72 MOLECULE: FIZZY-RELATED PROTEIN HOMOLOG;
COMPND 73 CHAIN: R;
COMPND 74 SYNONYM: FZR, CDC20-LIKE PROTEIN 1, CDH1/HCT1 HOMOLOG, HCDH1, FZR, C
COMPND 75 DC20-LIKE PROTEIN 1, CDH1/HCT1 HOMOLOG, HCDH1;
COMPND 76 MOL_ID: 16;
COMPND 77 MOLECULE: F-BOX ONLY PROTEIN 5;
COMPND 78 CHAIN: S;
COMPND 79 SYNONYM: EARLY MITOTIC INHIBITOR 1, EARLY MITOTIC INHIBITOR 1;
COMPND 80 MOL_ID: 17;
COMPND 81 MOLECULE: PEPTIDE;
COMPND 82 CHAIN: T;
COMPND 83 MOL_ID: 18;
COMPND 84 MOLECULE: PEPTIDE;
COMPND 85 CHAIN: U;
COMPND 86 MOL_ID: 19;
COMPND 87 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26;
COMPND 88 CHAIN: W;
COMPND 89 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 12, APC12, CELL DIVISION
COMPND 90 CYCLE PROTEIN 26 HOMOLOG, ANAPHASE-PROMOTING COMPLEX SUBUNIT 12,
COMPND 91 APC12, CELL DIVISION CYCLE PROTEIN 26 HOMOLOG;
COMPND 92 MOL_ID: 20;
COMPND 93 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 7;
COMPND 94 CHAIN: X, Y;
COMPND 95 SYNONYM: APC7, CYCLOSOME SUBUNIT 7, APC7, CYCLOSOME SUBUNIT 7
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: HUMAN;
SOURCE 4 ORGANISM_TAXID: 9606;
SOURCE 5 MOL_ID: 2;
SOURCE 6 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 7 ORGANISM_COMMON: HUMAN;
SOURCE 8 ORGANISM_TAXID: 9606;
SOURCE 9 MOL_ID: 3;
SOURCE 10 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 11 ORGANISM_COMMON: HUMAN;
SOURCE 12 ORGANISM_TAXID: 9606;
SOURCE 13 MOL_ID: 4;
SOURCE 14 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 15 ORGANISM_COMMON: HUMAN;
SOURCE 16 ORGANISM_TAXID: 9606;
SOURCE 17 MOL_ID: 5;
SOURCE 18 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 19 ORGANISM_COMMON: HUMAN;
SOURCE 20 ORGANISM_TAXID: 9606;
SOURCE 21 MOL_ID: 6;
SOURCE 22 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 23 ORGANISM_COMMON: HUMAN;
SOURCE 24 ORGANISM_TAXID: 9606;
SOURCE 25 MOL_ID: 7;
SOURCE 26 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 27 ORGANISM_COMMON: HUMAN;
SOURCE 28 ORGANISM_TAXID: 9606;
SOURCE 29 MOL_ID: 8;
SOURCE 30 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 31 ORGANISM_COMMON: HUMAN;
SOURCE 32 ORGANISM_TAXID: 9606;
SOURCE 33 MOL_ID: 9;
SOURCE 34 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 35 ORGANISM_COMMON: HUMAN;
SOURCE 36 ORGANISM_TAXID: 9606;
SOURCE 37 MOL_ID: 10;
SOURCE 38 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 39 ORGANISM_COMMON: HUMAN;
SOURCE 40 ORGANISM_TAXID: 9606;
SOURCE 41 MOL_ID: 11;
SOURCE 42 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 43 ORGANISM_COMMON: HUMAN;
SOURCE 44 ORGANISM_TAXID: 9606;
SOURCE 45 MOL_ID: 12;
SOURCE 46 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 47 ORGANISM_COMMON: HUMAN;
SOURCE 48 ORGANISM_TAXID: 9606;
SOURCE 49 MOL_ID: 13;
SOURCE 50 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 51 ORGANISM_COMMON: HUMAN;
SOURCE 52 ORGANISM_TAXID: 9606;
SOURCE 53 MOL_ID: 14;
SOURCE 54 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 55 ORGANISM_COMMON: HUMAN;
SOURCE 56 ORGANISM_TAXID: 9606;
SOURCE 57 MOL_ID: 15;
SOURCE 58 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 59 ORGANISM_COMMON: HUMAN;
SOURCE 60 ORGANISM_TAXID: 9606;
SOURCE 61 MOL_ID: 16;
SOURCE 62 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 63 ORGANISM_COMMON: HUMAN;
SOURCE 64 ORGANISM_TAXID: 9606;
SOURCE 65 MOL_ID: 17;
SOURCE 66 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 67 ORGANISM_COMMON: HUMAN;
SOURCE 68 ORGANISM_TAXID: 9606;
SOURCE 69 MOL_ID: 18;
SOURCE 70 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 71 ORGANISM_COMMON: HUMAN;
SOURCE 72 ORGANISM_TAXID: 9606;
SOURCE 73 MOL_ID: 19;
SOURCE 74 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 75 ORGANISM_COMMON: HUMAN;
SOURCE 76 ORGANISM_TAXID: 9606;
SOURCE 77 MOL_ID: 20;
SOURCE 78 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 79 ORGANISM_COMMON: HUMAN;
SOURCE 80 ORGANISM_TAXID: 9606
KEYWDS UBIQUITINATION, CELL CYCLE, APC/C, APC SUBUNITS, ANAPHASE PROMOTING
KEYWDS 2 COMPLEX
EXPDTA ELECTRON MICROSCOPY
AUTHOR L.CHANG,Z.ZHANG,J.YANG,S.H.MCLAUGHLIN,D.BARFORD
REVDAT 5 24-APR-19 4UI9 1 SCALE
REVDAT 4 02-AUG-17 4UI9 1
REVDAT 3 01-JUL-15 4UI9 1 JRNL
REVDAT 2 24-JUN-15 4UI9 1 REMARK
REVDAT 1 17-JUN-15 4UI9 0
JRNL AUTH L.CHANG,Z.ZHANG,J.YANG,S.H.MCLAUGHLIN,D.BARFORD
JRNL TITL ATOMIC STRUCTURE OF THE APC AND ITS MECHANISM OF PROTEIN
JRNL TITL 2 UBIQUITINATION
JRNL REF NATURE V. 522 450 2015
JRNL REFN ISSN 0028-0836
JRNL PMID 26083744
JRNL DOI 10.1038/NATURE14471
REMARK 2
REMARK 2 RESOLUTION. 3.60 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : REFMAC, RELION
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : NULL
REMARK 3 REFINEMENT SPACE : NULL
REMARK 3 REFINEMENT PROTOCOL : NULL
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : 1.360
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.600
REMARK 3 NUMBER OF PARTICLES : 202084
REMARK 3 CTF CORRECTION METHOD : NULL
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 4UI9 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE.
REMARK 100 THE DEPOSITION ID IS D_1290063266.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : CRYO EM
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : HUMAN ANAPHASE-PROMOTING
REMARK 245 COMPLEX
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.20
REMARK 245 SAMPLE SUPPORT DETAILS : HOLEY CARBON
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 8.00
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : 09-FEB-14
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TECNAI F30
REMARK 245 DETECTOR TYPE : FEI FALCON II (4K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : 2000.00
REMARK 245 MAXIMUM DEFOCUS (NM) : 4000.00
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : NULL
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 27.00
REMARK 245 ILLUMINATION MODE : FLOOD BEAM
REMARK 245 NOMINAL MAGNIFICATION : 78000
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 23-MERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 23-MERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,
REMARK 350 AND CHAINS: K, L, M, N, O, P, R, S, T,
REMARK 350 AND CHAINS: U, W, X, Y
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A 1
REMARK 465 SER A 2
REMARK 465 ASN A 3
REMARK 465 PHE A 4
REMARK 465 TYR A 5
REMARK 465 GLU A 6
REMARK 465 GLU A 7
REMARK 465 ARG A 8
REMARK 465 THR A 9
REMARK 465 THR A 10
REMARK 465 GLY A 59
REMARK 465 SER A 60
REMARK 465 LEU A 61
REMARK 465 GLN A 62
REMARK 465 GLU A 63
REMARK 465 VAL A 64
REMARK 465 THR A 65
REMARK 465 ILE A 66
REMARK 465 HIS A 67
REMARK 465 GLU A 68
REMARK 465 LYS A 69
REMARK 465 GLN A 70
REMARK 465 GLN A 135
REMARK 465 ASP A 136
REMARK 465 LYS A 137
REMARK 465 SER A 138
REMARK 465 GLU A 139
REMARK 465 LYS A 140
REMARK 465 ALA A 141
REMARK 465 TYR A 142
REMARK 465 SER A 143
REMARK 465 SER A 144
REMARK 465 ASN A 145
REMARK 465 ALA A 193
REMARK 465 SER A 194
REMARK 465 SER A 195
REMARK 465 HIS A 196
REMARK 465 GLU A 197
REMARK 465 VAL A 198
REMARK 465 PRO A 199
REMARK 465 PRO A 200
REMARK 465 GLY A 201
REMARK 465 SER A 202
REMARK 465 PRO A 203
REMARK 465 ARG A 204
REMARK 465 GLU A 205
REMARK 465 SER A 227
REMARK 465 GLY A 228
REMARK 465 SER A 229
REMARK 465 LEU A 230
REMARK 465 PHE A 231
REMARK 465 GLY A 232
REMARK 465 SER A 233
REMARK 465 SER A 234
REMARK 465 ARG A 235
REMARK 465 ALA A 296
REMARK 465 THR A 297
REMARK 465 SER A 298
REMARK 465 SER A 299
REMARK 465 SER A 300
REMARK 465 LEU A 301
REMARK 465 THR A 302
REMARK 465 ALA A 303
REMARK 465 HIS A 304
REMARK 465 LEU A 305
REMARK 465 ARG A 306
REMARK 465 SER A 307
REMARK 465 LEU A 308
REMARK 465 SER A 309
REMARK 465 LYS A 310
REMARK 465 GLY A 311
REMARK 465 ASP A 312
REMARK 465 SER A 313
REMARK 465 PRO A 314
REMARK 465 VAL A 315
REMARK 465 THR A 316
REMARK 465 SER A 317
REMARK 465 PRO A 318
REMARK 465 PHE A 319
REMARK 465 GLN A 320
REMARK 465 ASN A 321
REMARK 465 TYR A 322
REMARK 465 SER A 323
REMARK 465 SER A 324
REMARK 465 ILE A 325
REMARK 465 HIS A 326
REMARK 465 SER A 327
REMARK 465 GLN A 328
REMARK 465 SER A 329
REMARK 465 ARG A 330
REMARK 465 SER A 331
REMARK 465 THR A 332
REMARK 465 SER A 333
REMARK 465 SER A 334
REMARK 465 PRO A 335
REMARK 465 SER A 336
REMARK 465 LEU A 337
REMARK 465 HIS A 338
REMARK 465 SER A 339
REMARK 465 ARG A 340
REMARK 465 SER A 341
REMARK 465 PRO A 342
REMARK 465 SER A 343
REMARK 465 ILE A 344
REMARK 465 SER A 345
REMARK 465 ASN A 346
REMARK 465 MET A 347
REMARK 465 ALA A 348
REMARK 465 ALA A 349
REMARK 465 LEU A 350
REMARK 465 SER A 351
REMARK 465 ARG A 352
REMARK 465 ALA A 353
REMARK 465 HIS A 354
REMARK 465 SER A 355
REMARK 465 PRO A 356
REMARK 465 ALA A 357
REMARK 465 LEU A 358
REMARK 465 GLY A 359
REMARK 465 VAL A 360
REMARK 465 HIS A 361
REMARK 465 SER A 362
REMARK 465 PHE A 363
REMARK 465 SER A 364
REMARK 465 GLY A 365
REMARK 465 VAL A 366
REMARK 465 GLN A 367
REMARK 465 ARG A 368
REMARK 465 PHE A 369
REMARK 465 ASN A 370
REMARK 465 ILE A 371
REMARK 465 SER A 372
REMARK 465 SER A 373
REMARK 465 HIS A 374
REMARK 465 ASN A 375
REMARK 465 GLN A 376
REMARK 465 SER A 377
REMARK 465 PRO A 378
REMARK 465 LYS A 379
REMARK 465 ARG A 380
REMARK 465 HIS A 381
REMARK 465 SER A 382
REMARK 465 ILE A 383
REMARK 465 SER A 384
REMARK 465 HIS A 385
REMARK 465 SER A 386
REMARK 465 PRO A 387
REMARK 465 ASN A 388
REMARK 465 SER A 389
REMARK 465 ASN A 390
REMARK 465 SER A 391
REMARK 465 ASN A 392
REMARK 465 GLY A 393
REMARK 465 SER A 394
REMARK 465 PHE A 395
REMARK 465 LEU A 396
REMARK 465 ALA A 397
REMARK 465 PRO A 398
REMARK 465 GLU A 399
REMARK 465 THR A 400
REMARK 465 GLU A 401
REMARK 465 GLU A 415
REMARK 465 THR A 416
REMARK 465 ILE A 417
REMARK 465 THR A 418
REMARK 465 ASN A 419
REMARK 465 ILE A 420
REMARK 465 ARG A 421
REMARK 465 GLU A 422
REMARK 465 LYS A 423
REMARK 465 ASN A 461
REMARK 465 ASP A 462
REMARK 465 LYS A 463
REMARK 465 LEU A 514
REMARK 465 PRO A 515
REMARK 465 ALA A 516
REMARK 465 PRO A 517
REMARK 465 SER A 518
REMARK 465 LEU A 519
REMARK 465 THR A 520
REMARK 465 MET A 521
REMARK 465 SER A 522
REMARK 465 ASN A 523
REMARK 465 THR A 524
REMARK 465 MET A 525
REMARK 465 PRO A 526
REMARK 465 ARG A 527
REMARK 465 PRO A 528
REMARK 465 SER A 529
REMARK 465 THR A 530
REMARK 465 PRO A 531
REMARK 465 LEU A 532
REMARK 465 ASP A 533
REMARK 465 GLY A 534
REMARK 465 VAL A 535
REMARK 465 SER A 536
REMARK 465 THR A 537
REMARK 465 PRO A 538
REMARK 465 LYS A 539
REMARK 465 PRO A 540
REMARK 465 LEU A 541
REMARK 465 SER A 542
REMARK 465 LYS A 543
REMARK 465 LEU A 544
REMARK 465 LEU A 545
REMARK 465 GLY A 546
REMARK 465 SER A 547
REMARK 465 LEU A 548
REMARK 465 ASP A 549
REMARK 465 GLU A 550
REMARK 465 VAL A 551
REMARK 465 VAL A 552
REMARK 465 LEU A 553
REMARK 465 LEU A 554
REMARK 465 SER A 555
REMARK 465 PRO A 556
REMARK 465 VAL A 557
REMARK 465 PRO A 558
REMARK 465 GLU A 559
REMARK 465 LEU A 560
REMARK 465 ARG A 561
REMARK 465 ASP A 562
REMARK 465 SER A 563
REMARK 465 SER A 564
REMARK 465 LYS A 565
REMARK 465 LEU A 566
REMARK 465 HIS A 567
REMARK 465 ASP A 568
REMARK 465 SER A 569
REMARK 465 LEU A 570
REMARK 465 TYR A 571
REMARK 465 ASN A 572
REMARK 465 GLU A 573
REMARK 465 ASP A 574
REMARK 465 CYS A 575
REMARK 465 THR A 576
REMARK 465 PHE A 577
REMARK 465 GLN A 578
REMARK 465 GLN A 579
REMARK 465 LEU A 580
REMARK 465 GLY A 581
REMARK 465 ASN A 671
REMARK 465 THR A 672
REMARK 465 ASP A 673
REMARK 465 ARG A 674
REMARK 465 LEU A 675
REMARK 465 ALA A 676
REMARK 465 TRP A 677
REMARK 465 THR A 678
REMARK 465 ARG A 679
REMARK 465 ASN A 680
REMARK 465 PHE A 681
REMARK 465 ASP A 682
REMARK 465 PHE A 683
REMARK 465 GLU A 684
REMARK 465 GLY A 685
REMARK 465 SER A 686
REMARK 465 LEU A 687
REMARK 465 SER A 688
REMARK 465 PRO A 689
REMARK 465 VAL A 690
REMARK 465 ILE A 691
REMARK 465 ALA A 692
REMARK 465 PRO A 693
REMARK 465 LYS A 694
REMARK 465 LYS A 695
REMARK 465 ALA A 696
REMARK 465 ARG A 697
REMARK 465 PRO A 698
REMARK 465 SER A 699
REMARK 465 GLU A 700
REMARK 465 THR A 701
REMARK 465 GLY A 702
REMARK 465 SER A 703
REMARK 465 ASP A 704
REMARK 465 ASP A 705
REMARK 465 ASP A 706
REMARK 465 TRP A 707
REMARK 465 GLU A 708
REMARK 465 TYR A 709
REMARK 465 LEU A 710
REMARK 465 LEU A 711
REMARK 465 ASN A 712
REMARK 465 SER A 713
REMARK 465 ASP A 714
REMARK 465 TYR A 715
REMARK 465 HIS A 716
REMARK 465 GLN A 717
REMARK 465 ASN A 718
REMARK 465 VAL A 719
REMARK 465 GLU A 720
REMARK 465 SER A 721
REMARK 465 HIS A 722
REMARK 465 LEU A 723
REMARK 465 LEU A 724
REMARK 465 ASN A 725
REMARK 465 ARG A 726
REMARK 465 SER A 727
REMARK 465 LEU A 728
REMARK 465 CYS A 729
REMARK 465 LEU A 730
REMARK 465 SER A 731
REMARK 465 PRO A 732
REMARK 465 SER A 733
REMARK 465 GLU A 734
REMARK 465 ALA A 735
REMARK 465 SER A 736
REMARK 465 GLN A 737
REMARK 465 MET A 738
REMARK 465 LYS A 739
REMARK 465 ASP A 740
REMARK 465 GLU A 741
REMARK 465 ASP A 742
REMARK 465 PHE A 743
REMARK 465 SER A 744
REMARK 465 GLN A 745
REMARK 465 ASN A 746
REMARK 465 LEU A 747
REMARK 465 SER A 748
REMARK 465 LEU A 749
REMARK 465 ASP A 750
REMARK 465 SER A 751
REMARK 465 SER A 752
REMARK 465 THR A 753
REMARK 465 LEU A 754
REMARK 465 LEU A 755
REMARK 465 PHE A 756
REMARK 465 ARG A 815
REMARK 465 THR A 816
REMARK 465 THR A 817
REMARK 465 GLY A 818
REMARK 465 GLN A 819
REMARK 465 VAL A 820
REMARK 465 CYS A 821
REMARK 465 THR A 822
REMARK 465 ILE A 823
REMARK 465 ASP A 824
REMARK 465 PRO A 825
REMARK 465 GLY A 826
REMARK 465 GLN A 827
REMARK 465 THR A 828
REMARK 465 GLY A 829
REMARK 465 PHE A 830
REMARK 465 MET A 831
REMARK 465 HIS A 832
REMARK 465 HIS A 833
REMARK 465 PRO A 834
REMARK 465 SER A 835
REMARK 465 PHE A 836
REMARK 465 PHE A 837
REMARK 465 THR A 838
REMARK 465 GLY A 883
REMARK 465 ASP A 884
REMARK 465 GLU A 885
REMARK 465 SER A 886
REMARK 465 LEU A 887
REMARK 465 VAL A 888
REMARK 465 SER A 889
REMARK 465 ASP A 890
REMARK 465 GLU A 891
REMARK 465 SER A 892
REMARK 465 SER A 893
REMARK 465 GLN A 894
REMARK 465 TYR A 895
REMARK 465 LEU A 896
REMARK 465 THR A 897
REMARK 465 ARG A 898
REMARK 465 ILE A 899
REMARK 465 THR A 900
REMARK 465 ILE A 901
REMARK 465 ALA A 902
REMARK 465 PRO A 903
REMARK 465 GLN A 904
REMARK 465 LYS A 905
REMARK 465 LEU A 906
REMARK 465 GLN A 907
REMARK 465 VAL A 908
REMARK 465 GLU A 909
REMARK 465 GLN A 910
REMARK 465 GLU A 911
REMARK 465 GLU A 912
REMARK 465 ASN A 913
REMARK 465 ARG A 914
REMARK 465 PHE A 915
REMARK 465 SER A 916
REMARK 465 PHE A 917
REMARK 465 ARG A 918
REMARK 465 HIS A 919
REMARK 465 SER A 920
REMARK 465 THR A 921
REMARK 465 SER A 922
REMARK 465 VAL A 923
REMARK 465 ALA A 987
REMARK 465 CYS A 988
REMARK 465 GLU A 989
REMARK 465 GLY A 990
REMARK 465 ASN A 991
REMARK 465 LEU A 992
REMARK 465 PRO A 993
REMARK 465 LYS A 994
REMARK 465 GLY A 995
REMARK 465 LYS A 996
REMARK 465 SER A 997
REMARK 465 VAL A 998
REMARK 465 LEU A 999
REMARK 465 SER A 1000
REMARK 465 SER A 1001
REMARK 465 ASP A 1002
REMARK 465 VAL A 1003
REMARK 465 PRO A 1004
REMARK 465 SER A 1005
REMARK 465 GLY A 1006
REMARK 465 THR A 1007
REMARK 465 GLU A 1008
REMARK 465 THR A 1009
REMARK 465 GLU A 1010
REMARK 465 GLU A 1011
REMARK 465 GLU A 1012
REMARK 465 ARG A 1334
REMARK 465 ARG A 1335
REMARK 465 PHE A 1336
REMARK 465 GLN A 1337
REMARK 465 THR A 1338
REMARK 465 GLY A 1339
REMARK 465 MET A 1340
REMARK 465 HIS A 1341
REMARK 465 ARG A 1342
REMARK 465 GLU A 1343
REMARK 465 LYS A 1344
REMARK 465 HIS A 1345
REMARK 465 LYS A 1346
REMARK 465 SER A 1438
REMARK 465 ILE A 1439
REMARK 465 SER A 1440
REMARK 465 LEU A 1441
REMARK 465 SER A 1442
REMARK 465 GLU A 1443
REMARK 465 ILE A 1444
REMARK 465 GLU A 1445
REMARK 465 LEU A 1446
REMARK 465 PRO A 1447
REMARK 465 CYS A 1448
REMARK 465 SER A 1449
REMARK 465 GLU A 1450
REMARK 465 ASP A 1451
REMARK 465 SER A 1681
REMARK 465 LYS A 1682
REMARK 465 GLY A 1683
REMARK 465 PRO A 1712
REMARK 465 MET A 1713
REMARK 465 GLY A 1714
REMARK 465 TRP A 1715
REMARK 465 GLN A 1716
REMARK 465 SER A 1717
REMARK 465 LEU A 1718
REMARK 465 LEU A 1719
REMARK 465 ALA A 1720
REMARK 465 GLN A 1721
REMARK 465 THR A 1722
REMARK 465 VAL A 1723
REMARK 465 ALA A 1724
REMARK 465 ASN A 1725
REMARK 465 ARG A 1726
REMARK 465 PRO A 1738
REMARK 465 GLU A 1739
REMARK 465 THR A 1740
REMARK 465 ILE A 1741
REMARK 465 GLU A 1831
REMARK 465 ARG A 1832
REMARK 465 LEU A 1833
REMARK 465 GLN A 1834
REMARK 465 ASN A 1835
REMARK 465 HIS A 1836
REMARK 465 PRO A 1837
REMARK 465 LYS A 1838
REMARK 465 ARG A 1839
REMARK 465 GLY A 1840
REMARK 465 LEU A 1841
REMARK 465 GLY A 1877
REMARK 465 GLN A 1878
REMARK 465 PRO A 1879
REMARK 465 GLN A 1901
REMARK 465 HIS A 1902
REMARK 465 LEU A 1903
REMARK 465 PRO A 1904
REMARK 465 PRO A 1905
REMARK 465 ILE A 1906
REMARK 465 GLY A 1907
REMARK 465 LEU A 1908
REMARK 465 GLU A 1909
REMARK 465 GLY A 1910
REMARK 465 PRO A 1936
REMARK 465 LEU A 1937
REMARK 465 LEU A 1938
REMARK 465 LEU A 1939
REMARK 465 GLY A 1940
REMARK 465 ASN A 1941
REMARK 465 PRO A 1942
REMARK 465 GLN A 1943
REMARK 465 PRO A 1944
REMARK 465 MET A 1945
REMARK 465 VAL A 1946
REMARK 465 MET A 1947
REMARK 465 MET C 7
REMARK 465 VAL C 8
REMARK 465 PRO C 9
REMARK 465 VAL C 10
REMARK 465 ALA C 11
REMARK 465 VAL C 12
REMARK 465 THR C 13
REMARK 465 ALA C 14
REMARK 465 ALA C 15
REMARK 465 VAL C 16
REMARK 465 ALA C 17
REMARK 465 PRO C 18
REMARK 465 VAL C 19
REMARK 465 LEU C 20
REMARK 465 SER C 21
REMARK 465 ILE C 22
REMARK 465 ASN C 23
REMARK 465 SER C 24
REMARK 465 ASP C 25
REMARK 465 GLY C 501
REMARK 465 GLU C 502
REMARK 465 ILE C 503
REMARK 465 VAL C 504
REMARK 465 GLU C 505
REMARK 465 HIS C 506
REMARK 465 LEU C 507
REMARK 465 GLU C 508
REMARK 465 ASN C 558
REMARK 465 GLN C 559
REMARK 465 GLY C 560
REMARK 465 GLU C 561
REMARK 465 THR C 562
REMARK 465 PRO C 563
REMARK 465 THR C 564
REMARK 465 THR C 565
REMARK 465 GLU C 566
REMARK 465 VAL C 567
REMARK 465 PRO C 568
REMARK 465 ALA C 569
REMARK 465 PRO C 570
REMARK 465 PHE C 571
REMARK 465 PHE C 572
REMARK 465 LEU C 573
REMARK 465 PRO C 574
REMARK 465 ALA C 575
REMARK 465 SER C 576
REMARK 465 LEU C 577
REMARK 465 SER C 578
REMARK 465 ALA C 579
REMARK 465 ASN C 580
REMARK 465 ASN C 581
REMARK 465 THR C 582
REMARK 465 PRO C 583
REMARK 465 THR C 584
REMARK 465 ARG C 585
REMARK 465 ARG C 586
REMARK 465 VAL C 587
REMARK 465 SER C 588
REMARK 465 PRO C 589
REMARK 465 LEU C 590
REMARK 465 ASN C 591
REMARK 465 LEU C 592
REMARK 465 SER C 593
REMARK 465 SER C 594
REMARK 465 VAL C 595
REMARK 465 THR C 596
REMARK 465 PRO C 597
REMARK 465 MET D 1
REMARK 465 PRO D 57
REMARK 465 ALA D 58
REMARK 465 SER D 59
REMARK 465 GLU D 60
REMARK 465 HIS D 61
REMARK 465 TYR D 62
REMARK 465 ASP D 63
REMARK 465 ASP D 64
REMARK 465 GLU D 65
REMARK 465 GLU D 66
REMARK 465 GLU D 67
REMARK 465 GLU D 68
REMARK 465 ASP D 69
REMARK 465 ASP D 70
REMARK 465 GLU D 71
REMARK 465 ASP D 72
REMARK 465 ASP D 73
REMARK 465 GLU D 74
REMARK 465 ASP D 75
REMARK 465 SER D 76
REMARK 465 GLU D 77
REMARK 465 GLU D 78
REMARK 465 ASP D 79
REMARK 465 SER D 80
REMARK 465 GLU D 81
REMARK 465 ASP D 82
REMARK 465 ASP D 83
REMARK 465 GLU D 84
REMARK 465 ASP D 85
REMARK 465 MET D 86
REMARK 465 GLN D 87
REMARK 465 ASP D 88
REMARK 465 MET D 89
REMARK 465 ASP D 90
REMARK 465 GLU D 91
REMARK 465 MET D 92
REMARK 465 ASN D 93
REMARK 465 ASP D 94
REMARK 465 TYR D 95
REMARK 465 ASN D 96
REMARK 465 GLU D 97
REMARK 465 SER D 98
REMARK 465 PRO D 99
REMARK 465 ASP D 100
REMARK 465 ASP D 101
REMARK 465 GLY D 102
REMARK 465 GLU D 103
REMARK 465 VAL D 104
REMARK 465 ASN D 105
REMARK 465 GLU D 106
REMARK 465 VAL D 107
REMARK 465 ASP D 108
REMARK 465 MET D 109
REMARK 465 GLU D 110
REMARK 465 GLY D 111
REMARK 465 ASN D 112
REMARK 465 GLU D 113
REMARK 465 GLN D 114
REMARK 465 ASP D 115
REMARK 465 GLN D 116
REMARK 465 ASP D 117
REMARK 465 GLN D 118
REMARK 465 TRP D 119
REMARK 465 MET D 120
REMARK 465 ILE D 121
REMARK 465 MET E 1
REMARK 465 ALA E 2
REMARK 465 ALA E 3
REMARK 465 SER E 4
REMARK 465 SER E 5
REMARK 465 SER E 6
REMARK 465 SER E 7
REMARK 465 SER E 8
REMARK 465 SER E 9
REMARK 465 ALA E 10
REMARK 465 GLY E 11
REMARK 465 GLY E 12
REMARK 465 VAL E 13
REMARK 465 SER E 14
REMARK 465 GLY E 15
REMARK 465 SER E 16
REMARK 465 SER E 17
REMARK 465 VAL E 18
REMARK 465 THR E 19
REMARK 465 GLY E 20
REMARK 465 SER E 21
REMARK 465 GLY E 22
REMARK 465 PHE E 23
REMARK 465 SER E 24
REMARK 465 VAL E 25
REMARK 465 SER E 26
REMARK 465 ASP E 27
REMARK 465 LEU E 28
REMARK 465 ALA E 29
REMARK 465 PRO E 30
REMARK 465 PRO E 31
REMARK 465 ARG E 32
REMARK 465 LYS E 33
REMARK 465 ALA E 34
REMARK 465 LEU E 35
REMARK 465 PHE E 36
REMARK 465 THR E 37
REMARK 465 TYR E 38
REMARK 465 PRO E 39
REMARK 465 LYS E 40
REMARK 465 GLY E 41
REMARK 465 ALA E 42
REMARK 465 GLY E 43
REMARK 465 GLU E 44
REMARK 465 MET E 45
REMARK 465 LEU E 46
REMARK 465 GLU E 47
REMARK 465 ASP E 48
REMARK 465 GLY E 49
REMARK 465 SER E 50
REMARK 465 GLU E 51
REMARK 465 SER E 108
REMARK 465 SER E 109
REMARK 465 GLY E 110
REMARK 465 MET F 1
REMARK 465 THR F 2
REMARK 465 VAL F 3
REMARK 465 LEU F 4
REMARK 465 THR F 171
REMARK 465 SER F 172
REMARK 465 LEU F 173
REMARK 465 GLN F 174
REMARK 465 ASN F 175
REMARK 465 PHE F 176
REMARK 465 SER F 177
REMARK 465 ASN F 178
REMARK 465 CYS F 179
REMARK 465 LEU F 180
REMARK 465 PRO F 181
REMARK 465 ASN F 182
REMARK 465 SER F 183
REMARK 465 CYS F 184
REMARK 465 THR F 185
REMARK 465 THR F 186
REMARK 465 GLN F 187
REMARK 465 VAL F 188
REMARK 465 PRO F 189
REMARK 465 ASN F 190
REMARK 465 HIS F 191
REMARK 465 SER F 192
REMARK 465 LEU F 193
REMARK 465 SER F 194
REMARK 465 HIS F 195
REMARK 465 ARG F 196
REMARK 465 GLN F 197
REMARK 465 PRO F 198
REMARK 465 GLU F 199
REMARK 465 THR F 200
REMARK 465 VAL F 201
REMARK 465 LEU F 202
REMARK 465 THR F 203
REMARK 465 GLU F 204
REMARK 465 THR F 205
REMARK 465 PRO F 206
REMARK 465 GLN F 207
REMARK 465 ASP F 208
REMARK 465 THR F 209
REMARK 465 ILE F 210
REMARK 465 GLU F 211
REMARK 465 LEU F 212
REMARK 465 ASN F 213
REMARK 465 ARG F 214
REMARK 465 LEU F 215
REMARK 465 ASN F 216
REMARK 465 LEU F 217
REMARK 465 GLU F 218
REMARK 465 SER F 219
REMARK 465 SER F 220
REMARK 465 ASN F 221
REMARK 465 SER F 222
REMARK 465 LYS F 223
REMARK 465 TYR F 224
REMARK 465 SER F 225
REMARK 465 LEU F 226
REMARK 465 ASN F 227
REMARK 465 THR F 228
REMARK 465 ASP F 229
REMARK 465 SER F 230
REMARK 465 SER F 231
REMARK 465 VAL F 232
REMARK 465 SER F 233
REMARK 465 TYR F 234
REMARK 465 ILE F 235
REMARK 465 ASP F 236
REMARK 465 SER F 237
REMARK 465 ALA F 238
REMARK 465 VAL F 239
REMARK 465 ILE F 240
REMARK 465 SER F 241
REMARK 465 PRO F 242
REMARK 465 ASP F 243
REMARK 465 THR F 244
REMARK 465 VAL F 245
REMARK 465 PRO F 246
REMARK 465 LEU F 247
REMARK 465 GLY F 248
REMARK 465 THR F 249
REMARK 465 GLY F 250
REMARK 465 THR F 251
REMARK 465 SER F 252
REMARK 465 ILE F 253
REMARK 465 LEU F 254
REMARK 465 SER F 255
REMARK 465 LYS F 256
REMARK 465 GLN F 257
REMARK 465 VAL F 258
REMARK 465 GLN F 259
REMARK 465 ASN F 260
REMARK 465 LYS F 261
REMARK 465 PRO F 262
REMARK 465 LYS F 263
REMARK 465 THR F 264
REMARK 465 GLY F 265
REMARK 465 ARG F 266
REMARK 465 SER F 267
REMARK 465 LEU F 268
REMARK 465 LEU F 269
REMARK 465 GLY F 270
REMARK 465 GLY F 271
REMARK 465 PRO F 272
REMARK 465 ALA F 273
REMARK 465 ALA F 274
REMARK 465 LEU F 275
REMARK 465 SER F 276
REMARK 465 PRO F 277
REMARK 465 LEU F 278
REMARK 465 THR F 279
REMARK 465 PRO F 280
REMARK 465 SER F 281
REMARK 465 PHE F 282
REMARK 465 GLY F 283
REMARK 465 ILE F 284
REMARK 465 LEU F 285
REMARK 465 PRO F 286
REMARK 465 LEU F 287
REMARK 465 GLU F 288
REMARK 465 THR F 289
REMARK 465 PRO F 290
REMARK 465 SER F 291
REMARK 465 PRO F 292
REMARK 465 GLY F 293
REMARK 465 ASP F 294
REMARK 465 GLY F 295
REMARK 465 SER F 296
REMARK 465 TYR F 297
REMARK 465 LEU F 298
REMARK 465 GLN F 299
REMARK 465 ASN F 300
REMARK 465 TYR F 301
REMARK 465 THR F 302
REMARK 465 ASN F 303
REMARK 465 THR F 304
REMARK 465 PRO F 305
REMARK 465 PRO F 306
REMARK 465 VAL F 307
REMARK 465 ILE F 308
REMARK 465 ASP F 309
REMARK 465 VAL F 310
REMARK 465 PRO F 311
REMARK 465 SER F 312
REMARK 465 THR F 313
REMARK 465 GLY F 314
REMARK 465 ALA F 315
REMARK 465 PRO F 316
REMARK 465 SER F 317
REMARK 465 LYS F 318
REMARK 465 LYS F 319
REMARK 465 SER F 320
REMARK 465 VAL F 321
REMARK 465 ALA F 322
REMARK 465 ARG F 323
REMARK 465 ILE F 324
REMARK 465 GLY F 325
REMARK 465 GLN F 326
REMARK 465 THR F 327
REMARK 465 GLY F 328
REMARK 465 THR F 329
REMARK 465 LYS F 330
REMARK 465 SER F 331
REMARK 465 VAL F 332
REMARK 465 PHE F 333
REMARK 465 SER F 334
REMARK 465 GLN F 335
REMARK 465 SER F 336
REMARK 465 GLY F 337
REMARK 465 ASN F 338
REMARK 465 SER F 339
REMARK 465 ARG F 340
REMARK 465 GLU F 341
REMARK 465 VAL F 342
REMARK 465 THR F 343
REMARK 465 PRO F 344
REMARK 465 ILE F 345
REMARK 465 LEU F 346
REMARK 465 ALA F 347
REMARK 465 GLN F 348
REMARK 465 THR F 349
REMARK 465 GLN F 350
REMARK 465 SER F 351
REMARK 465 SER F 352
REMARK 465 GLY F 353
REMARK 465 PRO F 354
REMARK 465 GLN F 355
REMARK 465 THR F 356
REMARK 465 SER F 357
REMARK 465 THR F 358
REMARK 465 THR F 359
REMARK 465 PRO F 360
REMARK 465 GLN F 361
REMARK 465 VAL F 362
REMARK 465 LEU F 363
REMARK 465 SER F 364
REMARK 465 PRO F 365
REMARK 465 THR F 366
REMARK 465 ILE F 367
REMARK 465 THR F 368
REMARK 465 SER F 369
REMARK 465 PRO F 370
REMARK 465 PRO F 371
REMARK 465 ASN F 372
REMARK 465 ALA F 373
REMARK 465 LEU F 374
REMARK 465 PRO F 375
REMARK 465 ARG F 376
REMARK 465 ARG F 377
REMARK 465 SER F 378
REMARK 465 SER F 379
REMARK 465 ARG F 380
REMARK 465 LEU F 381
REMARK 465 PHE F 382
REMARK 465 THR F 383
REMARK 465 SER F 384
REMARK 465 ASP F 385
REMARK 465 SER F 386
REMARK 465 SER F 387
REMARK 465 THR F 388
REMARK 465 THR F 389
REMARK 465 LYS F 390
REMARK 465 GLU F 391
REMARK 465 ASN F 392
REMARK 465 SER F 393
REMARK 465 LYS F 394
REMARK 465 LYS F 395
REMARK 465 LEU F 396
REMARK 465 LYS F 397
REMARK 465 MET F 398
REMARK 465 LYS F 399
REMARK 465 PHE F 400
REMARK 465 PRO F 401
REMARK 465 PRO F 402
REMARK 465 GLU F 403
REMARK 465 ILE F 404
REMARK 465 PRO F 405
REMARK 465 ASN F 406
REMARK 465 ARG F 407
REMARK 465 LYS F 408
REMARK 465 THR F 409
REMARK 465 LYS F 410
REMARK 465 SER F 411
REMARK 465 LYS F 412
REMARK 465 THR F 413
REMARK 465 ASN F 414
REMARK 465 LYS F 415
REMARK 465 GLY F 416
REMARK 465 GLY F 417
REMARK 465 ILE F 418
REMARK 465 THR F 419
REMARK 465 GLN F 420
REMARK 465 PRO F 421
REMARK 465 ASN F 422
REMARK 465 ILE F 423
REMARK 465 ASN F 424
REMARK 465 ASP F 425
REMARK 465 SER F 426
REMARK 465 LEU F 427
REMARK 465 GLU F 428
REMARK 465 ILE F 429
REMARK 465 THR F 430
REMARK 465 LYS F 431
REMARK 465 LEU F 432
REMARK 465 ASP F 433
REMARK 465 SER F 434
REMARK 465 SER F 435
REMARK 465 ILE F 436
REMARK 465 ILE F 437
REMARK 465 SER F 438
REMARK 465 GLU F 439
REMARK 465 GLY F 440
REMARK 465 LYS F 441
REMARK 465 ILE F 442
REMARK 465 SER F 443
REMARK 465 THR F 444
REMARK 465 ILE F 445
REMARK 465 THR F 446
REMARK 465 PRO F 447
REMARK 465 GLN F 448
REMARK 465 ILE F 449
REMARK 465 GLN F 450
REMARK 465 TYR F 820
REMARK 465 LEU F 821
REMARK 465 PRO F 822
REMARK 465 ASP F 823
REMARK 465 ASP F 824
REMARK 465 GLU F 825
REMARK 465 GLU F 826
REMARK 465 PRO F 827
REMARK 465 ILE F 828
REMARK 465 THR F 829
REMARK 465 GLN F 830
REMARK 465 GLU F 831
REMARK 465 GLU F 832
REMARK 465 GLN F 833
REMARK 465 ILE F 834
REMARK 465 MET F 835
REMARK 465 GLY F 836
REMARK 465 THR F 837
REMARK 465 ASP F 838
REMARK 465 GLU F 839
REMARK 465 SER F 840
REMARK 465 GLN F 841
REMARK 465 GLU F 842
REMARK 465 SER F 843
REMARK 465 SER F 844
REMARK 465 MET F 845
REMARK 465 THR F 846
REMARK 465 ASP F 847
REMARK 465 ALA F 848
REMARK 465 ASP F 849
REMARK 465 ASP F 850
REMARK 465 THR F 851
REMARK 465 GLN F 852
REMARK 465 LEU F 853
REMARK 465 HIS F 854
REMARK 465 ALA F 855
REMARK 465 ALA F 856
REMARK 465 GLU F 857
REMARK 465 SER F 858
REMARK 465 ASP F 859
REMARK 465 GLU F 860
REMARK 465 PHE F 861
REMARK 465 LEU G 26
REMARK 465 GLU G 27
REMARK 465 THR G 28
REMARK 465 ARG G 29
REMARK 465 LYS G 30
REMARK 465 LYS G 31
REMARK 465 GLN G 32
REMARK 465 LYS G 33
REMARK 465 GLU G 34
REMARK 465 ASP G 35
REMARK 465 VAL G 36
REMARK 465 GLU G 37
REMARK 465 VAL G 38
REMARK 465 VAL G 39
REMARK 465 GLY G 40
REMARK 465 GLY G 41
REMARK 465 SER G 42
REMARK 465 ASP G 43
REMARK 465 GLY G 44
REMARK 465 GLU G 45
REMARK 465 GLY G 46
REMARK 465 ALA G 47
REMARK 465 ILE G 48
REMARK 465 GLY G 49
REMARK 465 LEU G 50
REMARK 465 SER G 51
REMARK 465 SER G 52
REMARK 465 ASP G 53
REMARK 465 PRO G 54
REMARK 465 LYS G 55
REMARK 465 SER G 56
REMARK 465 ARG G 57
REMARK 465 GLU G 58
REMARK 465 GLN G 59
REMARK 465 MET G 60
REMARK 465 ILE G 61
REMARK 465 ASN G 62
REMARK 465 ASP G 63
REMARK 465 ARG G 64
REMARK 465 ILE G 65
REMARK 465 GLY G 66
REMARK 465 TYR G 67
REMARK 465 LYS G 68
REMARK 465 PRO G 69
REMARK 465 GLN G 70
REMARK 465 PRO G 71
REMARK 465 LYS G 72
REMARK 465 PRO G 73
REMARK 465 ASN G 74
REMARK 465 ASN G 75
REMARK 465 ARG G 76
REMARK 465 SER G 77
REMARK 465 SER G 78
REMARK 465 GLN G 79
REMARK 465 PHE G 80
REMARK 465 GLY G 81
REMARK 465 SER G 82
REMARK 465 LEU G 83
REMARK 465 GLU G 84
REMARK 465 PHE G 85
REMARK 465 MET H 1
REMARK 465 THR H 2
REMARK 465 VAL H 3
REMARK 465 LEU H 4
REMARK 465 THR H 171
REMARK 465 SER H 172
REMARK 465 LEU H 173
REMARK 465 GLN H 174
REMARK 465 ASN H 175
REMARK 465 PHE H 176
REMARK 465 SER H 177
REMARK 465 ASN H 178
REMARK 465 CYS H 179
REMARK 465 LEU H 180
REMARK 465 PRO H 181
REMARK 465 ASN H 182
REMARK 465 SER H 183
REMARK 465 CYS H 184
REMARK 465 THR H 185
REMARK 465 THR H 186
REMARK 465 GLN H 187
REMARK 465 VAL H 188
REMARK 465 PRO H 189
REMARK 465 ASN H 190
REMARK 465 HIS H 191
REMARK 465 SER H 192
REMARK 465 LEU H 193
REMARK 465 SER H 194
REMARK 465 HIS H 195
REMARK 465 ARG H 196
REMARK 465 GLN H 197
REMARK 465 PRO H 198
REMARK 465 GLU H 199
REMARK 465 THR H 200
REMARK 465 VAL H 201
REMARK 465 LEU H 202
REMARK 465 THR H 203
REMARK 465 GLU H 204
REMARK 465 THR H 205
REMARK 465 PRO H 206
REMARK 465 GLN H 207
REMARK 465 ASP H 208
REMARK 465 THR H 209
REMARK 465 ILE H 210
REMARK 465 GLU H 211
REMARK 465 LEU H 212
REMARK 465 ASN H 213
REMARK 465 ARG H 214
REMARK 465 LEU H 215
REMARK 465 ASN H 216
REMARK 465 LEU H 217
REMARK 465 GLU H 218
REMARK 465 SER H 219
REMARK 465 SER H 220
REMARK 465 ASN H 221
REMARK 465 SER H 222
REMARK 465 LYS H 223
REMARK 465 TYR H 224
REMARK 465 SER H 225
REMARK 465 LEU H 226
REMARK 465 ASN H 227
REMARK 465 THR H 228
REMARK 465 ASP H 229
REMARK 465 SER H 230
REMARK 465 SER H 231
REMARK 465 VAL H 232
REMARK 465 SER H 233
REMARK 465 TYR H 234
REMARK 465 ILE H 235
REMARK 465 ASP H 236
REMARK 465 SER H 237
REMARK 465 ALA H 238
REMARK 465 VAL H 239
REMARK 465 ILE H 240
REMARK 465 SER H 241
REMARK 465 PRO H 242
REMARK 465 ASP H 243
REMARK 465 THR H 244
REMARK 465 VAL H 245
REMARK 465 PRO H 246
REMARK 465 LEU H 247
REMARK 465 GLY H 248
REMARK 465 THR H 249
REMARK 465 GLY H 250
REMARK 465 THR H 251
REMARK 465 SER H 252
REMARK 465 ILE H 253
REMARK 465 LEU H 254
REMARK 465 SER H 255
REMARK 465 LYS H 256
REMARK 465 GLN H 257
REMARK 465 VAL H 258
REMARK 465 GLN H 259
REMARK 465 ASN H 260
REMARK 465 LYS H 261
REMARK 465 PRO H 262
REMARK 465 LYS H 263
REMARK 465 THR H 264
REMARK 465 GLY H 265
REMARK 465 ARG H 266
REMARK 465 SER H 267
REMARK 465 LEU H 268
REMARK 465 LEU H 269
REMARK 465 GLY H 270
REMARK 465 GLY H 271
REMARK 465 PRO H 272
REMARK 465 ALA H 273
REMARK 465 ALA H 274
REMARK 465 LEU H 275
REMARK 465 SER H 276
REMARK 465 PRO H 277
REMARK 465 LEU H 278
REMARK 465 THR H 279
REMARK 465 PRO H 280
REMARK 465 SER H 281
REMARK 465 PHE H 282
REMARK 465 GLY H 283
REMARK 465 ILE H 284
REMARK 465 LEU H 285
REMARK 465 PRO H 286
REMARK 465 LEU H 287
REMARK 465 GLU H 288
REMARK 465 THR H 289
REMARK 465 PRO H 290
REMARK 465 SER H 291
REMARK 465 PRO H 292
REMARK 465 GLY H 293
REMARK 465 ASP H 294
REMARK 465 GLY H 295
REMARK 465 SER H 296
REMARK 465 TYR H 297
REMARK 465 LEU H 298
REMARK 465 GLN H 299
REMARK 465 ASN H 300
REMARK 465 TYR H 301
REMARK 465 THR H 302
REMARK 465 ASN H 303
REMARK 465 THR H 304
REMARK 465 PRO H 305
REMARK 465 PRO H 306
REMARK 465 VAL H 307
REMARK 465 ILE H 308
REMARK 465 ASP H 309
REMARK 465 VAL H 310
REMARK 465 PRO H 311
REMARK 465 SER H 312
REMARK 465 THR H 313
REMARK 465 GLY H 314
REMARK 465 ALA H 315
REMARK 465 PRO H 316
REMARK 465 SER H 317
REMARK 465 LYS H 318
REMARK 465 LYS H 319
REMARK 465 SER H 320
REMARK 465 VAL H 321
REMARK 465 ALA H 322
REMARK 465 ARG H 323
REMARK 465 ILE H 324
REMARK 465 GLY H 325
REMARK 465 GLN H 326
REMARK 465 THR H 327
REMARK 465 GLY H 328
REMARK 465 THR H 329
REMARK 465 LYS H 330
REMARK 465 SER H 331
REMARK 465 VAL H 332
REMARK 465 PHE H 333
REMARK 465 SER H 334
REMARK 465 GLN H 335
REMARK 465 SER H 336
REMARK 465 GLY H 337
REMARK 465 ASN H 338
REMARK 465 SER H 339
REMARK 465 ARG H 340
REMARK 465 GLU H 341
REMARK 465 VAL H 342
REMARK 465 THR H 343
REMARK 465 PRO H 344
REMARK 465 ILE H 345
REMARK 465 LEU H 346
REMARK 465 ALA H 347
REMARK 465 GLN H 348
REMARK 465 THR H 349
REMARK 465 GLN H 350
REMARK 465 SER H 351
REMARK 465 SER H 352
REMARK 465 GLY H 353
REMARK 465 PRO H 354
REMARK 465 GLN H 355
REMARK 465 THR H 356
REMARK 465 SER H 357
REMARK 465 THR H 358
REMARK 465 THR H 359
REMARK 465 PRO H 360
REMARK 465 GLN H 361
REMARK 465 VAL H 362
REMARK 465 LEU H 363
REMARK 465 SER H 364
REMARK 465 PRO H 365
REMARK 465 THR H 366
REMARK 465 ILE H 367
REMARK 465 THR H 368
REMARK 465 SER H 369
REMARK 465 PRO H 370
REMARK 465 PRO H 371
REMARK 465 ASN H 372
REMARK 465 ALA H 373
REMARK 465 LEU H 374
REMARK 465 PRO H 375
REMARK 465 ARG H 376
REMARK 465 ARG H 377
REMARK 465 SER H 378
REMARK 465 SER H 379
REMARK 465 ARG H 380
REMARK 465 LEU H 381
REMARK 465 PHE H 382
REMARK 465 THR H 383
REMARK 465 SER H 384
REMARK 465 ASP H 385
REMARK 465 SER H 386
REMARK 465 SER H 387
REMARK 465 THR H 388
REMARK 465 THR H 389
REMARK 465 LYS H 390
REMARK 465 GLU H 391
REMARK 465 ASN H 392
REMARK 465 SER H 393
REMARK 465 LYS H 394
REMARK 465 LYS H 395
REMARK 465 LEU H 396
REMARK 465 LYS H 397
REMARK 465 MET H 398
REMARK 465 LYS H 399
REMARK 465 PHE H 400
REMARK 465 PRO H 401
REMARK 465 PRO H 402
REMARK 465 GLU H 403
REMARK 465 ILE H 404
REMARK 465 PRO H 405
REMARK 465 ASN H 406
REMARK 465 ARG H 407
REMARK 465 LYS H 408
REMARK 465 THR H 409
REMARK 465 LYS H 410
REMARK 465 SER H 411
REMARK 465 LYS H 412
REMARK 465 THR H 413
REMARK 465 ASN H 414
REMARK 465 LYS H 415
REMARK 465 GLY H 416
REMARK 465 GLY H 417
REMARK 465 ILE H 418
REMARK 465 THR H 419
REMARK 465 GLN H 420
REMARK 465 PRO H 421
REMARK 465 ASN H 422
REMARK 465 ILE H 423
REMARK 465 ASN H 424
REMARK 465 ASP H 425
REMARK 465 SER H 426
REMARK 465 LEU H 427
REMARK 465 GLU H 428
REMARK 465 ILE H 429
REMARK 465 THR H 430
REMARK 465 LYS H 431
REMARK 465 LEU H 432
REMARK 465 ASP H 433
REMARK 465 SER H 434
REMARK 465 SER H 435
REMARK 465 ILE H 436
REMARK 465 ILE H 437
REMARK 465 SER H 438
REMARK 465 GLU H 439
REMARK 465 GLY H 440
REMARK 465 LYS H 441
REMARK 465 ILE H 442
REMARK 465 SER H 443
REMARK 465 THR H 444
REMARK 465 ILE H 445
REMARK 465 THR H 446
REMARK 465 PRO H 447
REMARK 465 GLN H 448
REMARK 465 ILE H 449
REMARK 465 GLN H 450
REMARK 465 PRO H 772
REMARK 465 LYS H 773
REMARK 465 GLY H 774
REMARK 465 ALA H 775
REMARK 465 ASN H 776
REMARK 465 ASN H 777
REMARK 465 GLN H 778
REMARK 465 ILE H 779
REMARK 465 LYS H 780
REMARK 465 GLU H 781
REMARK 465 ALA H 782
REMARK 465 ILE H 783
REMARK 465 ASP H 784
REMARK 465 LYS H 785
REMARK 465 ARG H 786
REMARK 465 TYR H 787
REMARK 465 LEU H 788
REMARK 465 PRO H 789
REMARK 465 ASP H 790
REMARK 465 ASP H 791
REMARK 465 GLU H 792
REMARK 465 GLU H 793
REMARK 465 PRO H 794
REMARK 465 ILE H 795
REMARK 465 THR H 796
REMARK 465 GLN H 797
REMARK 465 GLU H 798
REMARK 465 GLU H 799
REMARK 465 GLN H 800
REMARK 465 ILE H 801
REMARK 465 MET H 802
REMARK 465 GLY H 803
REMARK 465 THR H 804
REMARK 465 ASP H 805
REMARK 465 GLU H 806
REMARK 465 SER H 807
REMARK 465 GLN H 808
REMARK 465 GLU H 809
REMARK 465 SER H 810
REMARK 465 SER H 811
REMARK 465 MET H 812
REMARK 465 THR H 813
REMARK 465 ASP H 814
REMARK 465 ALA H 815
REMARK 465 ASP H 816
REMARK 465 ASP H 817
REMARK 465 THR H 818
REMARK 465 GLN H 819
REMARK 465 LEU H 820
REMARK 465 HIS H 821
REMARK 465 ALA H 822
REMARK 465 ALA H 823
REMARK 465 GLU H 824
REMARK 465 SER H 825
REMARK 465 ASP H 826
REMARK 465 GLU H 827
REMARK 465 PHE H 828
REMARK 465 MET I 1
REMARK 465 LEU I 2
REMARK 465 ARG I 3
REMARK 465 PHE I 4
REMARK 465 PRO I 5
REMARK 465 ASN I 130
REMARK 465 ALA I 131
REMARK 465 ASP I 431
REMARK 465 HIS I 432
REMARK 465 VAL I 433
REMARK 465 LEU I 434
REMARK 465 PRO I 435
REMARK 465 GLU I 436
REMARK 465 LEU I 437
REMARK 465 ASN I 438
REMARK 465 GLU I 458
REMARK 465 ALA I 459
REMARK 465 PRO I 460
REMARK 465 ASP I 461
REMARK 465 LEU I 462
REMARK 465 TYR I 463
REMARK 465 ASN I 464
REMARK 465 ARG I 465
REMARK 465 LYS I 466
REMARK 465 GLY I 467
REMARK 465 LYS I 468
REMARK 465 TYR I 469
REMARK 465 SER I 758
REMARK 465 ASP I 759
REMARK 465 GLU I 760
REMARK 465 GLU I 761
REMARK 465 GLU I 762
REMARK 465 GLU I 763
REMARK 465 ALA I 764
REMARK 465 SER I 765
REMARK 465 ASN I 766
REMARK 465 LYS I 767
REMARK 465 PRO I 768
REMARK 465 VAL I 769
REMARK 465 LYS I 770
REMARK 465 ILE I 771
REMARK 465 LYS I 772
REMARK 465 GLU I 773
REMARK 465 GLU I 774
REMARK 465 VAL I 775
REMARK 465 LEU I 776
REMARK 465 SER I 777
REMARK 465 GLU I 778
REMARK 465 SER I 779
REMARK 465 GLU I 780
REMARK 465 ALA I 781
REMARK 465 GLU I 782
REMARK 465 ASN I 783
REMARK 465 GLN I 784
REMARK 465 GLN I 785
REMARK 465 ALA I 786
REMARK 465 GLY I 787
REMARK 465 ALA I 788
REMARK 465 ALA I 789
REMARK 465 ALA I 790
REMARK 465 LEU I 791
REMARK 465 ALA I 792
REMARK 465 PRO I 793
REMARK 465 GLU I 794
REMARK 465 ILE I 795
REMARK 465 VAL I 796
REMARK 465 ILE I 797
REMARK 465 LYS I 798
REMARK 465 VAL I 799
REMARK 465 GLU I 800
REMARK 465 LYS I 801
REMARK 465 LEU I 802
REMARK 465 ASP I 803
REMARK 465 PRO I 804
REMARK 465 GLU I 805
REMARK 465 LEU I 806
REMARK 465 ASP I 807
REMARK 465 SER I 808
REMARK 465 MET J 1
REMARK 465 GLU J 96
REMARK 465 GLU J 97
REMARK 465 PRO J 98
REMARK 465 ILE J 99
REMARK 465 ASN J 100
REMARK 465 LYS J 101
REMARK 465 ARG J 102
REMARK 465 LEU J 103
REMARK 465 PHE J 104
REMARK 465 GLU J 105
REMARK 465 LYS J 106
REMARK 465 TYR J 107
REMARK 465 LEU J 108
REMARK 465 LYS J 109
REMARK 465 ASP J 110
REMARK 465 GLU J 111
REMARK 465 SER J 112
REMARK 465 GLY J 113
REMARK 465 PHE J 114
REMARK 465 LYS J 115
REMARK 465 ASP J 116
REMARK 465 PRO J 117
REMARK 465 SER J 118
REMARK 465 SER J 119
REMARK 465 ASP J 120
REMARK 465 TRP J 121
REMARK 465 GLU J 122
REMARK 465 MET J 123
REMARK 465 ILE J 534
REMARK 465 GLY J 535
REMARK 465 ALA J 536
REMARK 465 ASP J 537
REMARK 465 ILE J 538
REMARK 465 LYS J 539
REMARK 465 ASP J 540
REMARK 465 LYS J 541
REMARK 465 LEU J 542
REMARK 465 LYS J 543
REMARK 465 CYS J 544
REMARK 465 TYR J 545
REMARK 465 ASP J 546
REMARK 465 PHE J 547
REMARK 465 ASP J 548
REMARK 465 VAL J 549
REMARK 465 HIS J 550
REMARK 465 THR J 551
REMARK 465 MET J 552
REMARK 465 LYS J 553
REMARK 465 THR J 554
REMARK 465 LEU J 555
REMARK 465 LYS J 556
REMARK 465 ASN J 557
REMARK 465 ILE J 558
REMARK 465 ILE J 559
REMARK 465 SER J 560
REMARK 465 PRO J 561
REMARK 465 PRO J 562
REMARK 465 TRP J 563
REMARK 465 ASP J 564
REMARK 465 PHE J 565
REMARK 465 ARG J 566
REMARK 465 GLU J 567
REMARK 465 PHE J 568
REMARK 465 GLU J 569
REMARK 465 VAL J 570
REMARK 465 GLU J 571
REMARK 465 LYS J 572
REMARK 465 GLN J 573
REMARK 465 THR J 574
REMARK 465 ALA J 575
REMARK 465 GLU J 576
REMARK 465 GLU J 577
REMARK 465 THR J 578
REMARK 465 GLY J 579
REMARK 465 LEU J 580
REMARK 465 THR J 581
REMARK 465 PRO J 582
REMARK 465 LEU J 583
REMARK 465 GLU J 584
REMARK 465 THR J 585
REMARK 465 SER J 586
REMARK 465 ARG J 587
REMARK 465 LYS J 588
REMARK 465 THR J 589
REMARK 465 PRO J 590
REMARK 465 ASP J 591
REMARK 465 SER J 592
REMARK 465 ARG J 593
REMARK 465 PRO J 594
REMARK 465 SER J 595
REMARK 465 LEU J 596
REMARK 465 GLU J 597
REMARK 465 GLU J 598
REMARK 465 THR J 599
REMARK 465 PHE J 600
REMARK 465 GLU J 601
REMARK 465 ILE J 602
REMARK 465 GLU J 603
REMARK 465 MET J 604
REMARK 465 ASN J 605
REMARK 465 GLU J 606
REMARK 465 SER J 607
REMARK 465 ASP J 608
REMARK 465 MET J 609
REMARK 465 MET J 610
REMARK 465 LEU J 611
REMARK 465 GLU J 612
REMARK 465 THR J 613
REMARK 465 SER J 614
REMARK 465 MET J 615
REMARK 465 SER J 616
REMARK 465 ASP J 617
REMARK 465 HIS J 618
REMARK 465 SER J 619
REMARK 465 THR J 620
REMARK 465 MET K 1
REMARK 465 ASP K 94
REMARK 465 MET K 95
REMARK 465 GLU K 96
REMARK 465 GLU K 97
REMARK 465 PRO K 98
REMARK 465 ILE K 99
REMARK 465 ASN K 100
REMARK 465 LYS K 101
REMARK 465 ARG K 102
REMARK 465 LEU K 103
REMARK 465 PHE K 104
REMARK 465 GLU K 105
REMARK 465 LYS K 106
REMARK 465 TYR K 107
REMARK 465 LEU K 108
REMARK 465 LYS K 109
REMARK 465 ASP K 110
REMARK 465 GLU K 111
REMARK 465 SER K 112
REMARK 465 GLY K 113
REMARK 465 PHE K 114
REMARK 465 LYS K 115
REMARK 465 ASP K 116
REMARK 465 PRO K 117
REMARK 465 SER K 118
REMARK 465 SER K 119
REMARK 465 ASP K 120
REMARK 465 TRP K 121
REMARK 465 GLU K 122
REMARK 465 MET K 123
REMARK 465 SER K 124
REMARK 465 GLN K 125
REMARK 465 SER K 126
REMARK 465 GLY K 528
REMARK 465 ASP K 529
REMARK 465 SER K 530
REMARK 465 GLU K 531
REMARK 465 ALA K 532
REMARK 465 TYR K 533
REMARK 465 ILE K 534
REMARK 465 GLY K 535
REMARK 465 ALA K 536
REMARK 465 ASP K 537
REMARK 465 ILE K 538
REMARK 465 LYS K 539
REMARK 465 ASP K 540
REMARK 465 LYS K 541
REMARK 465 LEU K 542
REMARK 465 LYS K 543
REMARK 465 CYS K 544
REMARK 465 TYR K 545
REMARK 465 ASP K 546
REMARK 465 PHE K 547
REMARK 465 ASP K 548
REMARK 465 VAL K 549
REMARK 465 HIS K 550
REMARK 465 THR K 551
REMARK 465 MET K 552
REMARK 465 LYS K 553
REMARK 465 THR K 554
REMARK 465 LEU K 555
REMARK 465 LYS K 556
REMARK 465 ASN K 557
REMARK 465 ILE K 558
REMARK 465 ILE K 559
REMARK 465 SER K 560
REMARK 465 PRO K 561
REMARK 465 PRO K 562
REMARK 465 TRP K 563
REMARK 465 ASP K 564
REMARK 465 PHE K 565
REMARK 465 ARG K 566
REMARK 465 GLU K 567
REMARK 465 PHE K 568
REMARK 465 GLU K 569
REMARK 465 VAL K 570
REMARK 465 GLU K 571
REMARK 465 LYS K 572
REMARK 465 GLN K 573
REMARK 465 THR K 574
REMARK 465 ALA K 575
REMARK 465 GLU K 576
REMARK 465 GLU K 577
REMARK 465 THR K 578
REMARK 465 GLY K 579
REMARK 465 LEU K 580
REMARK 465 THR K 581
REMARK 465 PRO K 582
REMARK 465 LEU K 583
REMARK 465 GLU K 584
REMARK 465 THR K 585
REMARK 465 SER K 586
REMARK 465 ARG K 587
REMARK 465 LYS K 588
REMARK 465 THR K 589
REMARK 465 PRO K 590
REMARK 465 ASP K 591
REMARK 465 SER K 592
REMARK 465 ARG K 593
REMARK 465 PRO K 594
REMARK 465 SER K 595
REMARK 465 LEU K 596
REMARK 465 GLU K 597
REMARK 465 GLU K 598
REMARK 465 THR K 599
REMARK 465 PHE K 600
REMARK 465 GLU K 601
REMARK 465 ILE K 602
REMARK 465 GLU K 603
REMARK 465 MET K 604
REMARK 465 ASN K 605
REMARK 465 GLU K 606
REMARK 465 SER K 607
REMARK 465 ASP K 608
REMARK 465 MET K 609
REMARK 465 MET K 610
REMARK 465 LEU K 611
REMARK 465 GLU K 612
REMARK 465 THR K 613
REMARK 465 SER K 614
REMARK 465 MET K 615
REMARK 465 SER K 616
REMARK 465 ASP K 617
REMARK 465 HIS K 618
REMARK 465 SER K 619
REMARK 465 THR K 620
REMARK 465 THR L 2
REMARK 465 GLU M 40
REMARK 465 GLN M 41
REMARK 465 ASP M 42
REMARK 465 ASN M 43
REMARK 465 GLY M 44
REMARK 465 GLY M 45
REMARK 465 THR M 46
REMARK 465 THR M 47
REMARK 465 ASN M 68
REMARK 465 VAL M 69
REMARK 465 PRO M 70
REMARK 465 PRO M 71
REMARK 465 ILE M 72
REMARK 465 GLY M 73
REMARK 465 ASN M 74
REMARK 465 MET N 1
REMARK 465 ALA N 2
REMARK 465 ALA N 3
REMARK 465 ALA N 4
REMARK 465 VAL N 5
REMARK 465 VAL N 6
REMARK 465 VAL N 7
REMARK 465 ALA N 8
REMARK 465 GLU N 9
REMARK 465 GLY N 10
REMARK 465 ASP N 11
REMARK 465 SER N 12
REMARK 465 ASP N 13
REMARK 465 SER N 14
REMARK 465 GLY N 30
REMARK 465 LEU N 31
REMARK 465 VAL N 32
REMARK 465 PRO N 33
REMARK 465 PRO N 34
REMARK 465 ALA N 35
REMARK 465 ALA N 36
REMARK 465 LEU N 37
REMARK 465 GLY N 38
REMARK 465 LEU N 39
REMARK 465 VAL N 40
REMARK 465 SER N 41
REMARK 465 SER N 42
REMARK 465 ARG N 43
REMARK 465 THR N 44
REMARK 465 SER N 45
REMARK 465 GLY N 46
REMARK 465 ALA N 47
REMARK 465 VAL N 48
REMARK 465 PRO N 49
REMARK 465 PRO N 50
REMARK 465 LYS N 51
REMARK 465 GLU N 52
REMARK 465 GLY N 66
REMARK 465 LEU N 67
REMARK 465 HIS N 68
REMARK 465 SER N 69
REMARK 465 ASP N 103
REMARK 465 GLU N 104
REMARK 465 PRO N 105
REMARK 465 GLN N 106
REMARK 465 GLU N 192
REMARK 465 GLY N 193
REMARK 465 GLY N 194
REMARK 465 THR N 195
REMARK 465 CYS N 221
REMARK 465 ALA N 222
REMARK 465 GLY N 223
REMARK 465 CYS N 224
REMARK 465 SER N 225
REMARK 465 SER N 226
REMARK 465 ASP N 227
REMARK 465 LYS N 228
REMARK 465 GLN N 229
REMARK 465 GLN N 230
REMARK 465 CYS N 231
REMARK 465 LEU N 305
REMARK 465 GLN N 306
REMARK 465 ASP N 307
REMARK 465 GLY N 308
REMARK 465 PRO N 309
REMARK 465 ALA N 310
REMARK 465 ARG N 311
REMARK 465 PRO N 312
REMARK 465 ALA N 313
REMARK 465 SER N 314
REMARK 465 PRO N 315
REMARK 465 GLU N 316
REMARK 465 ALA N 317
REMARK 465 GLY N 318
REMARK 465 ASN N 319
REMARK 465 GLY N 444
REMARK 465 ASP N 445
REMARK 465 SER N 446
REMARK 465 ASP N 447
REMARK 465 GLY N 448
REMARK 465 THR N 449
REMARK 465 GLY N 450
REMARK 465 THR N 459
REMARK 465 ASP N 460
REMARK 465 PRO N 461
REMARK 465 ALA N 462
REMARK 465 SER N 463
REMARK 465 LEU N 464
REMARK 465 GLU N 465
REMARK 465 THR N 466
REMARK 465 GLY N 467
REMARK 465 GLN N 468
REMARK 465 ASP N 469
REMARK 465 SER N 470
REMARK 465 GLU N 471
REMARK 465 ASP N 472
REMARK 465 ASP N 473
REMARK 465 SER N 474
REMARK 465 GLY N 475
REMARK 465 ASP N 731
REMARK 465 SER N 732
REMARK 465 ASP N 733
REMARK 465 ASP N 734
REMARK 465 GLU N 735
REMARK 465 SER N 736
REMARK 465 ASP N 737
REMARK 465 SER N 738
REMARK 465 GLY N 739
REMARK 465 MET N 740
REMARK 465 ALA N 741
REMARK 465 SER N 742
REMARK 465 GLN N 743
REMARK 465 ALA N 744
REMARK 465 ASP N 745
REMARK 465 GLN N 746
REMARK 465 LYS N 747
REMARK 465 GLU N 748
REMARK 465 GLU N 749
REMARK 465 GLU N 750
REMARK 465 LEU N 751
REMARK 465 LEU N 752
REMARK 465 LEU N 753
REMARK 465 PHE N 754
REMARK 465 TRP N 755
REMARK 465 THR N 756
REMARK 465 TYR N 757
REMARK 465 ILE N 758
REMARK 465 GLN N 759
REMARK 465 ALA N 760
REMARK 465 MET N 761
REMARK 465 LEU N 762
REMARK 465 THR N 763
REMARK 465 ASN N 764
REMARK 465 LEU N 765
REMARK 465 GLU N 766
REMARK 465 SER N 767
REMARK 465 LEU N 768
REMARK 465 SER N 769
REMARK 465 LEU N 770
REMARK 465 ASP N 771
REMARK 465 ARG N 772
REMARK 465 ILE N 773
REMARK 465 TYR N 774
REMARK 465 ASN N 775
REMARK 465 MET N 776
REMARK 465 LEU N 777
REMARK 465 ARG N 778
REMARK 465 MET N 779
REMARK 465 PHE N 780
REMARK 465 VAL N 781
REMARK 465 VAL N 782
REMARK 465 THR N 783
REMARK 465 GLY N 784
REMARK 465 PRO N 785
REMARK 465 ALA N 786
REMARK 465 LEU N 787
REMARK 465 ALA N 788
REMARK 465 GLU N 789
REMARK 465 ILE N 790
REMARK 465 ASP N 791
REMARK 465 LEU N 792
REMARK 465 GLN N 793
REMARK 465 GLU N 794
REMARK 465 LEU N 795
REMARK 465 GLN N 796
REMARK 465 GLY N 797
REMARK 465 TYR N 798
REMARK 465 LEU N 799
REMARK 465 GLN N 800
REMARK 465 LYS N 801
REMARK 465 LYS N 802
REMARK 465 VAL N 803
REMARK 465 ARG N 804
REMARK 465 ASP N 805
REMARK 465 GLN N 806
REMARK 465 GLN N 807
REMARK 465 LEU N 808
REMARK 465 VAL N 809
REMARK 465 TYR N 810
REMARK 465 SER N 811
REMARK 465 ALA N 812
REMARK 465 GLY N 813
REMARK 465 VAL N 814
REMARK 465 TYR N 815
REMARK 465 ARG N 816
REMARK 465 LEU N 817
REMARK 465 PRO N 818
REMARK 465 LYS N 819
REMARK 465 ASN N 820
REMARK 465 CYS N 821
REMARK 465 SER N 822
REMARK 465 MET O 1
REMARK 465 ALA O 2
REMARK 465 SER O 3
REMARK 465 VAL O 4
REMARK 465 HIS O 5
REMARK 465 GLU O 6
REMARK 465 SER O 7
REMARK 465 LEU O 8
REMARK 465 TYR O 9
REMARK 465 PHE O 10
REMARK 465 ASN O 11
REMARK 465 PRO O 12
REMARK 465 MET O 13
REMARK 465 MET O 14
REMARK 465 THR O 15
REMARK 465 ASN O 16
REMARK 465 GLY O 17
REMARK 465 VAL O 18
REMARK 465 VAL O 19
REMARK 465 HIS O 20
REMARK 465 ALA O 21
REMARK 465 ASN O 22
REMARK 465 VAL O 23
REMARK 465 PHE O 24
REMARK 465 GLY O 25
REMARK 465 ILE O 26
REMARK 465 THR O 169A
REMARK 465 VAL O 170
REMARK 465 GLU O 171
REMARK 465 ASP O 172
REMARK 465 ALA O 173
REMARK 465 ASP O 174
REMARK 465 MET O 175
REMARK 465 GLU O 176
REMARK 465 LEU O 177
REMARK 465 THR O 178
REMARK 465 SER O 179
REMARK 465 ARG O 180
REMARK 465 ASP O 181
REMARK 465 GLU O 182
REMARK 465 GLY O 183
REMARK 465 GLU O 184
REMARK 465 ARG O 185
REMARK 465 LYS O 186
REMARK 465 MET O 187
REMARK 465 GLU O 188
REMARK 465 LYS O 189
REMARK 465 GLU O 190
REMARK 465 GLU O 191
REMARK 465 LEU O 192
REMARK 465 ASP O 193
REMARK 465 VAL O 194
REMARK 465 SER O 195
REMARK 465 VAL O 196
REMARK 465 ARG O 197
REMARK 465 GLU O 198
REMARK 465 GLU O 199
REMARK 465 GLU O 200
REMARK 465 VAL O 201
REMARK 465 SER O 202
REMARK 465 CYS O 203
REMARK 465 SER O 204
REMARK 465 GLY O 205
REMARK 465 ALA O 453
REMARK 465 VAL O 454
REMARK 465 ASN O 455
REMARK 465 ALA O 456
REMARK 465 GLY O 457
REMARK 465 VAL O 458
REMARK 465 HIS O 747
REMARK 465 GLY O 748
REMARK 465 MET P 7
REMARK 465 VAL P 8
REMARK 465 PRO P 9
REMARK 465 VAL P 10
REMARK 465 ALA P 11
REMARK 465 VAL P 12
REMARK 465 THR P 13
REMARK 465 ALA P 14
REMARK 465 ALA P 15
REMARK 465 VAL P 16
REMARK 465 ALA P 17
REMARK 465 PRO P 18
REMARK 465 VAL P 19
REMARK 465 LEU P 20
REMARK 465 SER P 21
REMARK 465 ILE P 22
REMARK 465 ASN P 23
REMARK 465 SER P 24
REMARK 465 ASP P 25
REMARK 465 VAL P 135
REMARK 465 ASP P 136
REMARK 465 SER P 137
REMARK 465 LEU P 138
REMARK 465 GLY P 139
REMARK 465 PRO P 140
REMARK 465 LEU P 141
REMARK 465 GLU P 142
REMARK 465 LYS P 143
REMARK 465 GLY P 144
REMARK 465 GLN P 145
REMARK 465 VAL P 146
REMARK 465 GLY P 501
REMARK 465 GLU P 502
REMARK 465 ILE P 503
REMARK 465 VAL P 504
REMARK 465 GLU P 505
REMARK 465 HIS P 506
REMARK 465 LEU P 507
REMARK 465 GLU P 508
REMARK 465 GLU P 509
REMARK 465 SER P 510
REMARK 465 PHE P 539
REMARK 465 ASN P 540
REMARK 465 ASP P 541
REMARK 465 THR P 542
REMARK 465 ARG P 543
REMARK 465 GLU P 544
REMARK 465 GLU P 545
REMARK 465 GLY P 546
REMARK 465 LYS P 547
REMARK 465 ALA P 548
REMARK 465 LEU P 549
REMARK 465 LEU P 550
REMARK 465 ARG P 551
REMARK 465 GLN P 552
REMARK 465 ILE P 553
REMARK 465 LEU P 554
REMARK 465 GLN P 555
REMARK 465 LEU P 556
REMARK 465 ARG P 557
REMARK 465 ASN P 558
REMARK 465 GLN P 559
REMARK 465 GLY P 560
REMARK 465 GLU P 561
REMARK 465 THR P 562
REMARK 465 PRO P 563
REMARK 465 THR P 564
REMARK 465 THR P 565
REMARK 465 GLU P 566
REMARK 465 VAL P 567
REMARK 465 PRO P 568
REMARK 465 ALA P 569
REMARK 465 PRO P 570
REMARK 465 PHE P 571
REMARK 465 PHE P 572
REMARK 465 LEU P 573
REMARK 465 PRO P 574
REMARK 465 ALA P 575
REMARK 465 SER P 576
REMARK 465 LEU P 577
REMARK 465 SER P 578
REMARK 465 ALA P 579
REMARK 465 ASN P 580
REMARK 465 ASN P 581
REMARK 465 THR P 582
REMARK 465 PRO P 583
REMARK 465 THR P 584
REMARK 465 ARG P 585
REMARK 465 ARG P 586
REMARK 465 VAL P 587
REMARK 465 SER P 588
REMARK 465 PRO P 589
REMARK 465 LEU P 590
REMARK 465 ASN P 591
REMARK 465 LEU P 592
REMARK 465 SER P 593
REMARK 465 SER P 594
REMARK 465 VAL P 595
REMARK 465 THR P 596
REMARK 465 PRO P 597
REMARK 465 MET R 1
REMARK 465 ASP R 2
REMARK 465 GLN R 3
REMARK 465 ASP R 4
REMARK 465 TYR R 5
REMARK 465 GLU R 6
REMARK 465 ARG R 7
REMARK 465 ARG R 8
REMARK 465 LEU R 9
REMARK 465 LEU R 10
REMARK 465 ARG R 11
REMARK 465 GLN R 12
REMARK 465 ILE R 13
REMARK 465 VAL R 14
REMARK 465 ILE R 15
REMARK 465 GLN R 16
REMARK 465 ASN R 17
REMARK 465 GLU R 18
REMARK 465 ASN R 19
REMARK 465 THR R 20
REMARK 465 MET R 21
REMARK 465 PRO R 22
REMARK 465 ARG R 23
REMARK 465 VAL R 24
REMARK 465 THR R 25
REMARK 465 GLU R 26
REMARK 465 MET R 27
REMARK 465 ARG R 28
REMARK 465 ARG R 29
REMARK 465 THR R 30
REMARK 465 LEU R 31
REMARK 465 THR R 32
REMARK 465 PRO R 33
REMARK 465 ALA R 34
REMARK 465 SER R 35
REMARK 465 SER R 36
REMARK 465 PRO R 37
REMARK 465 VAL R 38
REMARK 465 SER R 39
REMARK 465 SER R 40
REMARK 465 PRO R 41
REMARK 465 GLU R 68
REMARK 465 LYS R 69
REMARK 465 SER R 70
REMARK 465 PRO R 71
REMARK 465 SER R 72
REMARK 465 GLN R 73
REMARK 465 ASN R 74
REMARK 465 ARG R 75
REMARK 465 LYS R 76
REMARK 465 ALA R 77
REMARK 465 LYS R 78
REMARK 465 ASP R 79
REMARK 465 ALA R 80
REMARK 465 THR R 81
REMARK 465 SER R 82
REMARK 465 ASP R 83
REMARK 465 ASN R 84
REMARK 465 GLY R 85
REMARK 465 LYS R 86
REMARK 465 ASP R 87
REMARK 465 ASP R 109
REMARK 465 PRO R 110
REMARK 465 GLN R 111
REMARK 465 THR R 112
REMARK 465 GLU R 113
REMARK 465 ASP R 114
REMARK 465 ARG R 115
REMARK 465 ARG R 116
REMARK 465 LEU R 117
REMARK 465 GLN R 118
REMARK 465 PRO R 119
REMARK 465 SER R 120
REMARK 465 THR R 121
REMARK 465 PRO R 122
REMARK 465 GLU R 123
REMARK 465 LYS R 124
REMARK 465 SER R 133
REMARK 465 THR R 134
REMARK 465 LYS R 135
REMARK 465 ARG R 136
REMARK 465 SER R 137
REMARK 465 SER R 138
REMARK 465 PRO R 139
REMARK 465 ASP R 140
REMARK 465 ASP R 141
REMARK 465 GLY R 142
REMARK 465 ASN R 143
REMARK 465 ASP R 144
REMARK 465 VAL R 145
REMARK 465 PRO R 164
REMARK 465 ARG R 165
REMARK 465 LYS R 166
REMARK 465 PRO R 167
REMARK 465 THR R 168
REMARK 465 ARG R 169
REMARK 465 LYS R 170
REMARK 465 ILE R 171
REMARK 465 LYS R 475
REMARK 465 THR R 476
REMARK 465 ARG R 477
REMARK 465 SER R 478
REMARK 465 THR R 479
REMARK 465 LYS R 480
REMARK 465 GLU R 481
REMARK 465 SER R 482
REMARK 465 MET S 1
REMARK 465 SER S 2
REMARK 465 ARG S 3
REMARK 465 ARG S 4
REMARK 465 PRO S 5
REMARK 465 CYS S 6
REMARK 465 SER S 7
REMARK 465 CYS S 8
REMARK 465 ALA S 9
REMARK 465 LEU S 10
REMARK 465 ARG S 11
REMARK 465 PRO S 12
REMARK 465 PRO S 13
REMARK 465 ARG S 14
REMARK 465 CYS S 15
REMARK 465 SER S 16
REMARK 465 CYS S 17
REMARK 465 SER S 18
REMARK 465 ALA S 19
REMARK 465 SER S 20
REMARK 465 PRO S 21
REMARK 465 SER S 22
REMARK 465 ALA S 23
REMARK 465 VAL S 24
REMARK 465 THR S 25
REMARK 465 ALA S 26
REMARK 465 ALA S 27
REMARK 465 GLY S 28
REMARK 465 ARG S 29
REMARK 465 PRO S 30
REMARK 465 ARG S 31
REMARK 465 PRO S 32
REMARK 465 SER S 33
REMARK 465 ASP S 34
REMARK 465 SER S 35
REMARK 465 CYS S 36
REMARK 465 LYS S 37
REMARK 465 GLU S 38
REMARK 465 GLU S 39
REMARK 465 SER S 40
REMARK 465 SER S 41
REMARK 465 THR S 42
REMARK 465 LEU S 43
REMARK 465 SER S 44
REMARK 465 VAL S 45
REMARK 465 LYS S 46
REMARK 465 MET S 47
REMARK 465 LYS S 48
REMARK 465 CYS S 49
REMARK 465 ASP S 50
REMARK 465 PHE S 51
REMARK 465 ASN S 52
REMARK 465 CYS S 53
REMARK 465 ASN S 54
REMARK 465 HIS S 55
REMARK 465 VAL S 56
REMARK 465 HIS S 57
REMARK 465 SER S 58
REMARK 465 GLY S 59
REMARK 465 LEU S 60
REMARK 465 LYS S 61
REMARK 465 LEU S 62
REMARK 465 VAL S 63
REMARK 465 LYS S 64
REMARK 465 PRO S 65
REMARK 465 ASP S 66
REMARK 465 ASP S 67
REMARK 465 ILE S 68
REMARK 465 GLY S 69
REMARK 465 ARG S 70
REMARK 465 LEU S 71
REMARK 465 VAL S 72
REMARK 465 SER S 73
REMARK 465 TYR S 74
REMARK 465 THR S 75
REMARK 465 PRO S 76
REMARK 465 ALA S 77
REMARK 465 TYR S 78
REMARK 465 LEU S 79
REMARK 465 GLU S 80
REMARK 465 GLY S 81
REMARK 465 SER S 82
REMARK 465 CYS S 83
REMARK 465 LYS S 84
REMARK 465 ASP S 85
REMARK 465 CYS S 86
REMARK 465 ILE S 87
REMARK 465 LYS S 88
REMARK 465 ASP S 89
REMARK 465 TYR S 90
REMARK 465 GLU S 91
REMARK 465 ARG S 92
REMARK 465 LEU S 93
REMARK 465 SER S 94
REMARK 465 CYS S 95
REMARK 465 ILE S 96
REMARK 465 GLY S 97
REMARK 465 SER S 98
REMARK 465 PRO S 99
REMARK 465 ILE S 100
REMARK 465 VAL S 101
REMARK 465 SER S 102
REMARK 465 PRO S 103
REMARK 465 ARG S 104
REMARK 465 ILE S 105
REMARK 465 VAL S 106
REMARK 465 GLN S 107
REMARK 465 LEU S 108
REMARK 465 GLU S 109
REMARK 465 THR S 110
REMARK 465 GLU S 111
REMARK 465 SER S 112
REMARK 465 LYS S 113
REMARK 465 ARG S 114
REMARK 465 LEU S 115
REMARK 465 HIS S 116
REMARK 465 ASN S 117
REMARK 465 LYS S 118
REMARK 465 GLU S 119
REMARK 465 ASN S 120
REMARK 465 GLN S 121
REMARK 465 HIS S 122
REMARK 465 VAL S 123
REMARK 465 GLN S 124
REMARK 465 GLN S 125
REMARK 465 THR S 126
REMARK 465 LEU S 127
REMARK 465 ASN S 128
REMARK 465 SER S 129
REMARK 465 THR S 130
REMARK 465 ASN S 131
REMARK 465 GLU S 132
REMARK 465 ILE S 133
REMARK 465 GLU S 134
REMARK 465 ALA S 135
REMARK 465 LEU S 136
REMARK 465 GLU S 137
REMARK 465 THR S 138
REMARK 465 SER S 139
REMARK 465 ARG S 140
REMARK 465 LEU S 141
REMARK 465 TYR S 142
REMARK 465 GLU S 143
REMARK 465 ASP S 144
REMARK 465 SER S 145
REMARK 465 GLY S 146
REMARK 465 TYR S 147
REMARK 465 SER S 148
REMARK 465 SER S 149
REMARK 465 PHE S 150
REMARK 465 SER S 151
REMARK 465 LEU S 152
REMARK 465 GLN S 153
REMARK 465 SER S 154
REMARK 465 GLY S 155
REMARK 465 LEU S 156
REMARK 465 SER S 157
REMARK 465 GLU S 158
REMARK 465 HIS S 159
REMARK 465 GLU S 160
REMARK 465 GLU S 161
REMARK 465 GLY S 162
REMARK 465 SER S 163
REMARK 465 LEU S 164
REMARK 465 LEU S 165
REMARK 465 GLU S 166
REMARK 465 GLU S 167
REMARK 465 ASN S 168
REMARK 465 PHE S 169
REMARK 465 GLY S 170
REMARK 465 ASP S 171
REMARK 465 SER S 172
REMARK 465 LEU S 173
REMARK 465 GLN S 174
REMARK 465 SER S 175
REMARK 465 CYS S 176
REMARK 465 LEU S 177
REMARK 465 LEU S 178
REMARK 465 GLN S 179
REMARK 465 ILE S 180
REMARK 465 GLN S 181
REMARK 465 SER S 182
REMARK 465 PRO S 183
REMARK 465 ASP S 184
REMARK 465 GLN S 185
REMARK 465 TYR S 186
REMARK 465 PRO S 187
REMARK 465 ASN S 188
REMARK 465 LYS S 189
REMARK 465 ASN S 190
REMARK 465 LEU S 191
REMARK 465 LEU S 192
REMARK 465 PRO S 193
REMARK 465 VAL S 194
REMARK 465 LEU S 195
REMARK 465 HIS S 196
REMARK 465 PHE S 197
REMARK 465 GLU S 198
REMARK 465 LYS S 199
REMARK 465 VAL S 200
REMARK 465 VAL S 201
REMARK 465 CYS S 202
REMARK 465 SER S 203
REMARK 465 THR S 204
REMARK 465 LEU S 205
REMARK 465 LYS S 206
REMARK 465 LYS S 207
REMARK 465 ASN S 208
REMARK 465 ALA S 209
REMARK 465 LYS S 210
REMARK 465 ARG S 211
REMARK 465 ASN S 212
REMARK 465 PRO S 213
REMARK 465 LYS S 214
REMARK 465 VAL S 215
REMARK 465 ASP S 216
REMARK 465 ARG S 217
REMARK 465 GLU S 218
REMARK 465 MET S 219
REMARK 465 LEU S 220
REMARK 465 LYS S 221
REMARK 465 GLU S 222
REMARK 465 ILE S 223
REMARK 465 ILE S 224
REMARK 465 ALA S 225
REMARK 465 ARG S 226
REMARK 465 GLY S 227
REMARK 465 ASN S 228
REMARK 465 PHE S 229
REMARK 465 ARG S 230
REMARK 465 LEU S 231
REMARK 465 GLN S 232
REMARK 465 ASN S 233
REMARK 465 ILE S 234
REMARK 465 ILE S 235
REMARK 465 GLY S 236
REMARK 465 ARG S 237
REMARK 465 LYS S 238
REMARK 465 MET S 239
REMARK 465 GLY S 240
REMARK 465 LEU S 241
REMARK 465 GLU S 242
REMARK 465 CYS S 243
REMARK 465 VAL S 244
REMARK 465 ASP S 245
REMARK 465 ILE S 246
REMARK 465 LEU S 247
REMARK 465 SER S 248
REMARK 465 GLU S 249
REMARK 465 LEU S 250
REMARK 465 PHE S 251
REMARK 465 ARG S 252
REMARK 465 ARG S 253
REMARK 465 GLY S 254
REMARK 465 LEU S 255
REMARK 465 ARG S 256
REMARK 465 HIS S 257
REMARK 465 VAL S 258
REMARK 465 LEU S 259
REMARK 465 ALA S 260
REMARK 465 THR S 261
REMARK 465 ILE S 262
REMARK 465 LEU S 263
REMARK 465 ALA S 264
REMARK 465 GLN S 265
REMARK 465 LEU S 266
REMARK 465 SER S 267
REMARK 465 ASP S 268
REMARK 465 MET S 269
REMARK 465 ASP S 270
REMARK 465 LEU S 271
REMARK 465 ILE S 272
REMARK 465 ASN S 273
REMARK 465 VAL S 274
REMARK 465 SER S 275
REMARK 465 LYS S 276
REMARK 465 VAL S 277
REMARK 465 SER S 278
REMARK 465 THR S 279
REMARK 465 THR S 280
REMARK 465 TRP S 281
REMARK 465 LYS S 282
REMARK 465 LYS S 283
REMARK 465 ILE S 284
REMARK 465 LEU S 285
REMARK 465 GLU S 286
REMARK 465 ASP S 287
REMARK 465 ASP S 288
REMARK 465 LYS S 289
REMARK 465 GLY S 290
REMARK 465 ALA S 291
REMARK 465 PHE S 292
REMARK 465 GLN S 293
REMARK 465 LEU S 294
REMARK 465 TYR S 295
REMARK 465 SER S 296
REMARK 465 LYS S 297
REMARK 465 ALA S 298
REMARK 465 ILE S 299
REMARK 465 GLN S 300
REMARK 465 ARG S 301
REMARK 465 VAL S 302
REMARK 465 THR S 303
REMARK 465 GLU S 304
REMARK 465 ASN S 305
REMARK 465 ASN S 306
REMARK 465 ASN S 307
REMARK 465 LYS S 308
REMARK 465 PHE S 309
REMARK 465 SER S 310
REMARK 465 PRO S 311
REMARK 465 HIS S 312
REMARK 465 ALA S 313
REMARK 465 SER S 314
REMARK 465 THR S 315
REMARK 465 ARG S 316
REMARK 465 GLU S 317
REMARK 465 TYR S 318
REMARK 465 ALA S 332
REMARK 465 ALA S 333
REMARK 465 GLN S 334
REMARK 465 THR S 335
REMARK 465 SER S 336
REMARK 465 LEU S 337
REMARK 465 LYS S 338
REMARK 465 LYS S 339
REMARK 465 ASP S 340
REMARK 465 ALA S 341
REMARK 465 GLN S 342
REMARK 465 THR S 343
REMARK 465 LYS S 344
REMARK 465 LEU S 345
REMARK 465 SER S 346
REMARK 465 ASN S 347
REMARK 465 GLN S 348
REMARK 465 GLY S 349
REMARK 465 ASP S 350
REMARK 465 GLN S 351
REMARK 465 LYS S 352
REMARK 465 GLY S 353
REMARK 465 SER S 354
REMARK 465 THR S 355
REMARK 465 THR S 437
REMARK 465 LYS S 438
REMARK 465 LYS S 439
REMARK 465 SER S 440
REMARK 465 LYS S 441
REMARK 465 LYS S 442
REMARK 465 ASN S 443
REMARK 465 LEU S 444
REMARK 465 ARG S 445
REMARK 465 ARG S 446
REMARK 465 LEU S 447
REMARK 465 LEU W 26
REMARK 465 GLU W 27
REMARK 465 THR W 28
REMARK 465 ARG W 29
REMARK 465 LYS W 30
REMARK 465 LYS W 31
REMARK 465 GLN W 32
REMARK 465 LYS W 33
REMARK 465 GLU W 34
REMARK 465 ASP W 35
REMARK 465 VAL W 36
REMARK 465 GLU W 37
REMARK 465 VAL W 38
REMARK 465 VAL W 39
REMARK 465 GLY W 40
REMARK 465 GLY W 41
REMARK 465 SER W 42
REMARK 465 ASP W 43
REMARK 465 GLY W 44
REMARK 465 GLU W 45
REMARK 465 GLY W 46
REMARK 465 ALA W 47
REMARK 465 ILE W 48
REMARK 465 GLY W 49
REMARK 465 LEU W 50
REMARK 465 SER W 51
REMARK 465 SER W 52
REMARK 465 ASP W 53
REMARK 465 PRO W 54
REMARK 465 LYS W 55
REMARK 465 SER W 56
REMARK 465 ARG W 57
REMARK 465 GLU W 58
REMARK 465 GLN W 59
REMARK 465 MET W 60
REMARK 465 ILE W 61
REMARK 465 ASN W 62
REMARK 465 ASP W 63
REMARK 465 ARG W 64
REMARK 465 ILE W 65
REMARK 465 GLY W 66
REMARK 465 TYR W 67
REMARK 465 LYS W 68
REMARK 465 PRO W 69
REMARK 465 GLN W 70
REMARK 465 PRO W 71
REMARK 465 LYS W 72
REMARK 465 PRO W 73
REMARK 465 ASN W 74
REMARK 465 ASN W 75
REMARK 465 ARG W 76
REMARK 465 SER W 77
REMARK 465 SER W 78
REMARK 465 GLN W 79
REMARK 465 PHE W 80
REMARK 465 GLY W 81
REMARK 465 SER W 82
REMARK 465 LEU W 83
REMARK 465 GLU W 84
REMARK 465 PHE W 85
REMARK 465 MET X 35
REMARK 465 SER X 111
REMARK 465 LYS X 112
REMARK 465 THR X 113
REMARK 465 SER X 114
REMARK 465 LYS X 115
REMARK 465 VAL X 116
REMARK 465 ARG X 117
REMARK 465 PRO X 118
REMARK 465 SER X 119
REMARK 465 THR X 120
REMARK 465 GLY X 121
REMARK 465 ASN X 122
REMARK 465 SER X 123
REMARK 465 ALA X 124
REMARK 465 SER X 125
REMARK 465 THR X 126
REMARK 465 PRO X 127
REMARK 465 GLN X 128
REMARK 465 SER X 129
REMARK 465 GLN X 130
REMARK 465 CYS X 131
REMARK 465 ASN X 541
REMARK 465 ASP X 542
REMARK 465 GLN X 543
REMARK 465 LYS X 544
REMARK 465 SER X 545
REMARK 465 LEU X 546
REMARK 465 GLU X 547
REMARK 465 GLY X 548
REMARK 465 MET X 549
REMARK 465 GLN X 550
REMARK 465 LYS X 551
REMARK 465 MET X 552
REMARK 465 GLU X 553
REMARK 465 LYS X 554
REMARK 465 GLU X 555
REMARK 465 GLU X 556
REMARK 465 SER X 557
REMARK 465 PRO X 558
REMARK 465 THR X 559
REMARK 465 ASP X 560
REMARK 465 ALA X 561
REMARK 465 THR X 562
REMARK 465 GLN X 563
REMARK 465 GLU X 564
REMARK 465 GLU X 565
REMARK 465 ASP X 566
REMARK 465 VAL X 567
REMARK 465 ASP X 568
REMARK 465 ASP X 569
REMARK 465 MET X 570
REMARK 465 GLU X 571
REMARK 465 GLY X 572
REMARK 465 SER X 573
REMARK 465 GLY X 574
REMARK 465 GLU X 575
REMARK 465 GLU X 576
REMARK 465 GLY X 577
REMARK 465 ASP X 578
REMARK 465 LEU X 579
REMARK 465 GLU X 580
REMARK 465 GLY X 581
REMARK 465 SER X 582
REMARK 465 ASP X 583
REMARK 465 SER X 584
REMARK 465 GLU X 585
REMARK 465 ALA X 586
REMARK 465 ALA X 587
REMARK 465 GLN X 588
REMARK 465 TRP X 589
REMARK 465 ALA X 590
REMARK 465 ASP X 591
REMARK 465 GLN X 592
REMARK 465 GLU X 593
REMARK 465 GLN X 594
REMARK 465 TRP X 595
REMARK 465 PHE X 596
REMARK 465 GLY X 597
REMARK 465 MET X 598
REMARK 465 GLN X 599
REMARK 465 MET Y 35
REMARK 465 SER Y 111
REMARK 465 LYS Y 112
REMARK 465 THR Y 113
REMARK 465 SER Y 114
REMARK 465 LYS Y 115
REMARK 465 VAL Y 116
REMARK 465 ARG Y 117
REMARK 465 PRO Y 118
REMARK 465 SER Y 119
REMARK 465 THR Y 120
REMARK 465 GLY Y 121
REMARK 465 ASN Y 122
REMARK 465 SER Y 123
REMARK 465 ALA Y 124
REMARK 465 SER Y 125
REMARK 465 THR Y 126
REMARK 465 PRO Y 127
REMARK 465 GLN Y 128
REMARK 465 SER Y 129
REMARK 465 GLN Y 130
REMARK 465 CYS Y 131
REMARK 465 GLU Y 553
REMARK 465 LYS Y 554
REMARK 465 GLU Y 555
REMARK 465 GLU Y 556
REMARK 465 SER Y 557
REMARK 465 PRO Y 558
REMARK 465 THR Y 559
REMARK 465 ASP Y 560
REMARK 465 ALA Y 561
REMARK 465 THR Y 562
REMARK 465 GLN Y 563
REMARK 465 GLU Y 564
REMARK 465 GLU Y 565
REMARK 465 ASP Y 566
REMARK 465 VAL Y 567
REMARK 465 ASP Y 568
REMARK 465 ASP Y 569
REMARK 465 MET Y 570
REMARK 465 GLU Y 571
REMARK 465 GLY Y 572
REMARK 465 SER Y 573
REMARK 465 GLY Y 574
REMARK 465 GLU Y 575
REMARK 465 GLU Y 576
REMARK 465 GLY Y 577
REMARK 465 ASP Y 578
REMARK 465 LEU Y 579
REMARK 465 GLU Y 580
REMARK 465 GLY Y 581
REMARK 465 SER Y 582
REMARK 465 ASP Y 583
REMARK 465 SER Y 584
REMARK 465 GLU Y 585
REMARK 465 ALA Y 586
REMARK 465 ALA Y 587
REMARK 465 GLN Y 588
REMARK 465 TRP Y 589
REMARK 465 ALA Y 590
REMARK 465 ASP Y 591
REMARK 465 GLN Y 592
REMARK 465 GLU Y 593
REMARK 465 GLN Y 594
REMARK 465 TRP Y 595
REMARK 465 PHE Y 596
REMARK 465 GLY Y 597
REMARK 465 MET Y 598
REMARK 465 GLN Y 599
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470 M RES CSSEQI ATOMS
REMARK 470 LEU A 48 CG CD1 CD2
REMARK 470 TRP A 49 CG CD1 CD2 NE1 CE2 CE3 CZ2
REMARK 470 TRP A 49 CZ3 CH2
REMARK 470 SER A 50 OG
REMARK 470 SER A 51 OG
REMARK 470 ASP A 52 CG OD1 OD2
REMARK 470 LEU A 57 CG CD1 CD2
REMARK 470 VAL A 58 CG1 CG2
REMARK 470 LYS A 71 CG CD CE NZ
REMARK 470 GLU A 82 CG CD OE1 OE2
REMARK 470 ILE A 83 CG1 CG2 CD1
REMARK 470 GLN A 109 CG CD OE1 NE2
REMARK 470 GLU A 146 CG CD OE1 OE2
REMARK 470 GLU A 148 CG CD OE1 OE2
REMARK 470 LYS A 184 CG CD CE NZ
REMARK 470 PRO A 206 CG CD
REMARK 470 GLU A 219 CG CD OE1 OE2
REMARK 470 VAL A 236 CG1 CG2
REMARK 470 ASP A 241 CG OD1 OD2
REMARK 470 ASN A 264 CG OD1 ND2
REMARK 470 LYS A 275 CG CD CE NZ
REMARK 470 SER A 276 OG
REMARK 470 GLU A 277 CG CD OE1 OE2
REMARK 470 GLU A 278 CG CD OE1 OE2
REMARK 470 GLU A 279 CG CD OE1 OE2
REMARK 470 ASN A 280 CG OD1 ND2
REMARK 470 VAL A 281 CG1 CG2
REMARK 470 VAL A 282 CG1 CG2
REMARK 470 LEU A 283 CG CD1 CD2
REMARK 470 LYS A 284 CG CD CE NZ
REMARK 470 PHE A 285 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 SER A 286 OG
REMARK 470 GLU A 287 CG CD OE1 OE2
REMARK 470 GLN A 288 CG CD OE1 NE2
REMARK 470 PRO A 292 CG CD
REMARK 470 GLN A 293 CG CD OE1 NE2
REMARK 470 ASN A 294 CG OD1 ND2
REMARK 470 VAL A 295 CG1 CG2
REMARK 470 CYS A 408 SG
REMARK 470 THR A 414 OG1 CG2
REMARK 470 ASN A 424 CG OD1 ND2
REMARK 470 SER A 425 OG
REMARK 470 GLU A 447 CG CD OE1 OE2
REMARK 470 GLN A 465 CG CD OE1 NE2
REMARK 470 LYS A 484 CG CD CE NZ
REMARK 470 ASP A 486 CG OD1 OD2
REMARK 470 GLU A 492 CG CD OE1 OE2
REMARK 470 SER A 494 OG
REMARK 470 LYS A 631 CG CD CE NZ
REMARK 470 GLU A 632 CG CD OE1 OE2
REMARK 470 PRO A 651 CG CD
REMARK 470 TYR A 670 CG CD1 CD2 CE1 CE2 CZ OH
REMARK 470 VAL A 814 CG1 CG2
REMARK 470 SER A 839 OG
REMARK 470 GLU A 840 CG CD OE1 OE2
REMARK 470 GLU A 855 CG CD OE1 OE2
REMARK 470 MET A 857 CG SD CE
REMARK 470 LYS A 985 CG CD CE NZ
REMARK 470 GLN A 986 CG CD OE1 NE2
REMARK 470 TYR A1054 CG CD1 CD2 CE1 CE2 CZ OH
REMARK 470 GLU A1056 CG CD OE1 OE2
REMARK 470 GLU A1059 CG CD OE1 OE2
REMARK 470 GLU A1098 CG CD OE1 OE2
REMARK 470 ASP A1126 CG OD1 OD2
REMARK 470 MET A1285 CG SD CE
REMARK 470 GLU A1286 CG CD OE1 OE2
REMARK 470 CYS A1288 SG
REMARK 470 ASP A1318 CG OD1 OD2
REMARK 470 ASP A1356 CG OD1 OD2
REMARK 470 THR A1357 OG1 CG2
REMARK 470 MET A1393 CG SD CE
REMARK 470 GLU A1402 CG CD OE1 OE2
REMARK 470 ASP A1418 CG OD1 OD2
REMARK 470 ASN A1422 CG OD1 ND2
REMARK 470 ARG A1435 CG CD NE CZ NH1 NH2
REMARK 470 GLU A1436 CG CD OE1 OE2
REMARK 470 ASN A1437 CG OD1 ND2
REMARK 470 LEU A1452 CG CD1 CD2
REMARK 470 GLU A1549 CG CD OE1 OE2
REMARK 470 GLU A1659 CG CD OE1 OE2
REMARK 470 LEU A1680 CG CD1 CD2
REMARK 470 LYS A1709 CG CD CE NZ
REMARK 470 ASN A1727 CG OD1 ND2
REMARK 470 ASN A1763 CG OD1 ND2
REMARK 470 LYS A1767 CG CD CE NZ
REMARK 470 ARG A1806 CG CD NE CZ NH1 NH2
REMARK 470 HIS A1829 CG ND1 CD2 CE1 NE2
REMARK 470 GLN A1830 CG CD OE1 NE2
REMARK 470 GLU A1846 CG CD OE1 OE2
REMARK 470 VAL A1865 CG1 CG2
REMARK 470 GLU A1882 CG CD OE1 OE2
REMARK 470 LEU A1892 CG CD1 CD2
REMARK 470 SER A1911 OG
REMARK 470 THR A1912 OG1 CG2
REMARK 470 SER A1913 OG
REMARK 470 PHE A1914 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 GLU A1916 CG CD OE1 OE2
REMARK 470 LEU A1917 CG CD1 CD2
REMARK 470 LEU A1918 CG CD1 CD2
REMARK 470 PHE A1919 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 LYS A1920 CG CD CE NZ
REMARK 470 PHE A1921 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 LYS A1922 CG CD CE NZ
REMARK 470 GLN A1923 CG CD OE1 NE2
REMARK 470 LEU A1924 CG CD1 CD2
REMARK 470 LYS A1925 CG CD CE NZ
REMARK 470 MET A1926 CG SD CE
REMARK 470 PRO A1927 CG CD
REMARK 470 VAL A1928 CG1 CG2
REMARK 470 ARG A1929 CG CD NE CZ NH1 NH2
REMARK 470 LEU A1931 CG CD1 CD2
REMARK 470 LEU A1932 CG CD1 CD2
REMARK 470 ARG A1933 CG CD NE CZ NH1 NH2
REMARK 470 LEU A1934 CG CD1 CD2
REMARK 470 ASN B 19 CG OD1 ND2
REMARK 470 ASP B 20 CG OD1 OD2
REMARK 470 GLU B 21 CG CD OE1 OE2
REMARK 470 ASN B 22 CG OD1 ND2
REMARK 470 LYS B 38 CG CD CE NZ
REMARK 470 VAL B 39 CG1 CG2
REMARK 470 PRO B 40 CG CD
REMARK 470 ASP B 42 CG OD1 OD2
REMARK 470 GLN B 67 CG CD OE1 NE2
REMARK 470 GLN B 68 CG CD OE1 NE2
REMARK 470 GLN B 70 CG CD OE1 NE2
REMARK 470 GLU C 69 CG CD OE1 OE2
REMARK 470 CYS C 109 SG
REMARK 470 LYS C 281 CG CD CE NZ
REMARK 470 ASP C 496 CG OD1 OD2
REMARK 470 SER C 499 OG
REMARK 470 CYS C 500 SG
REMARK 470 ASP D 21 CG OD1 OD2
REMARK 470 ARG D 22 CG CD NE CZ NH1 NH2
REMARK 470 PRO D 23 CG CD
REMARK 470 CYS D 24 SG
REMARK 470 LEU D 51 CG CD1 CD2
REMARK 470 LYS D 56 CG CD CE NZ
REMARK 470 ARG E 52 CG CD NE CZ NH1 NH2
REMARK 470 LEU E 54 CG CD1 CD2
REMARK 470 CYS E 55 SG
REMARK 470 GLN F 5 CG CD OE1 NE2
REMARK 470 PHE F 168 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 LYS F 169 CG CD CE NZ
REMARK 470 PHE F 170 CB CG CD1 CD2 CE1 CE2 CZ
REMARK 470 PHE F 452 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ASN F 453 CG OD1 ND2
REMARK 470 LEU F 454 CG CD1 CD2
REMARK 470 LYS F 456 CG CD CE NZ
REMARK 470 SER F 475 OG
REMARK 470 SER F 484 OG
REMARK 470 ASP F 767 CG OD1 OD2
REMARK 470 PRO F 768 CG CD
REMARK 470 LYS F 769 CG CD CE NZ
REMARK 470 ASN F 778 CG OD1 ND2
REMARK 470 ASN F 810 CG OD1 ND2
REMARK 470 GLN F 811 CG CD OE1 NE2
REMARK 470 ILE F 812 CG1 CG2 CD1
REMARK 470 LYS F 813 CG CD CE NZ
REMARK 470 GLU F 814 CG CD OE1 OE2
REMARK 470 ILE F 816 CG1 CG2 CD1
REMARK 470 ASP F 817 CG OD1 OD2
REMARK 470 LYS F 818 CG CD CE NZ
REMARK 470 ARG F 819 CG CD NE CZ NH1 NH2
REMARK 470 LYS G 24 CG CD CE NZ
REMARK 470 ASP G 25 CG OD1 OD2
REMARK 470 GLN H 5 CG CD OE1 NE2
REMARK 470 PHE H 168 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 LYS H 169 CG CD CE NZ
REMARK 470 PHE H 170 CB CG CD1 CD2 CE1 CE2 CZ
REMARK 470 PHE H 452 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 ASN H 453 CG OD1 ND2
REMARK 470 LEU H 454 CG CD1 CD2
REMARK 470 SER H 475 OG
REMARK 470 SER H 484 OG
REMARK 470 ASP H 771 CG OD1 OD2
REMARK 470 PHE I 128 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 TYR I 129 CG CD1 CD2 CE1 CE2 CZ OH
REMARK 470 GLU I 132 CD OE1 OE2
REMARK 470 ASP I 133 CG OD1 OD2
REMARK 470 ASN I 136 CG OD1 ND2
REMARK 470 LYS I 147 CG CD CE NZ
REMARK 470 ASN I 148 CG OD1 ND2
REMARK 470 TYR I 149 CG CD1 CD2 CE1 CE2 CZ OH
REMARK 470 ASN I 151 CG OD1 ND2
REMARK 470 THR I 152 OG1 CG2
REMARK 470 LYS I 154 CG CD CE NZ
REMARK 470 GLU I 159 CG CD OE1 OE2
REMARK 470 ASN I 160 CG OD1 ND2
REMARK 470 GLN I 292 CG CD OE1 NE2
REMARK 470 GLU I 293 CG CD OE1 OE2
REMARK 470 LYS I 294 CG CD CE NZ
REMARK 470 ASN I 295 CG OD1 ND2
REMARK 470 THR I 296 OG1 CG2
REMARK 470 THR I 297 OG1 CG2
REMARK 470 THR I 298 OG1 CG2
REMARK 470 SER I 299 OG
REMARK 470 LYS I 346 CG CD CE NZ
REMARK 470 GLU I 402 CG CD OE1 OE2
REMARK 470 MET I 411 CG SD CE
REMARK 470 LYS I 412 CG CD CE NZ
REMARK 470 ASP I 430 CG OD1 OD2
REMARK 470 LYS I 439 CG CD CE NZ
REMARK 470 PHE I 470 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 LYS I 480 CG CD CE NZ
REMARK 470 ASP I 481 CG OD1 OD2
REMARK 470 GLU I 482 CG CD OE1 OE2
REMARK 470 ASP I 483 CG OD1 OD2
REMARK 470 ASP I 484 CG OD1 OD2
REMARK 470 ASP I 485 CG OD1 OD2
REMARK 470 LEU I 486 CG CD1 CD2
REMARK 470 VAL I 487 CG1 CG2
REMARK 470 SER I 488 OG
REMARK 470 ASN I 495 CG OD1 ND2
REMARK 470 ARG I 567 CG CD NE CZ NH1 NH2
REMARK 470 ARG I 659 CG CD NE CZ NH1 NH2
REMARK 470 GLU I 660 CG CD OE1 OE2
REMARK 470 ARG I 662 CG CD NE CZ NH1 NH2
REMARK 470 GLU I 756 CG CD OE1 OE2
REMARK 470 ASN J 2 CG OD1 ND2
REMARK 470 LEU J 3 CG CD1 CD2
REMARK 470 GLU J 4 CG CD OE1 OE2
REMARK 470 ARG J 5 CG CD NE CZ NH1 NH2
REMARK 470 SER J 124 OG
REMARK 470 GLN J 125 CG CD OE1 NE2
REMARK 470 SER J 126 OG
REMARK 470 GLU J 222 CG CD OE1 OE2
REMARK 470 GLU J 347 CG CD OE1 OE2
REMARK 470 GLU J 524 CG CD OE1 OE2
REMARK 470 ASP J 529 CG OD1 OD2
REMARK 470 SER J 530 OG
REMARK 470 GLU J 531 CG CD OE1 OE2
REMARK 470 ASN K 2 CG OD1 ND2
REMARK 470 LEU K 3 CG CD1 CD2
REMARK 470 GLU K 4 CG CD OE1 OE2
REMARK 470 ARG K 5 CG CD NE CZ NH1 NH2
REMARK 470 LYS K 214 CG CD CE NZ
REMARK 470 GLU K 228 CG CD OE1 OE2
REMARK 470 SER L 164 OG
REMARK 470 SER L 165 OG
REMARK 470 ILE L 166 CG1 CG2 CD1
REMARK 470 LYS L 168 CG CD CE NZ
REMARK 470 PHE L 169 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 PRO L 170 CG CD
REMARK 470 ARG L 171 CG CD NE CZ NH1 NH2
REMARK 470 CYS L 172 SG
REMARK 470 THR L 173 OG1 CG2
REMARK 470 THR L 174 OG1 CG2
REMARK 470 ILE L 175 CG1 CG2 CD1
REMARK 470 ASP L 176 CG OD1 OD2
REMARK 470 ARG N 15 CG CD NE CZ NH1 NH2
REMARK 470 PRO N 16 CG CD
REMARK 470 GLN N 18 CG CD OE1 NE2
REMARK 470 GLU N 19 CG CD OE1 OE2
REMARK 470 LEU N 20 CG CD1 CD2
REMARK 470 LEU N 21 CG CD1 CD2
REMARK 470 VAL N 22 CG1 CG2
REMARK 470 TRP N 24 CG CD1 CD2 NE1 CE2 CE3 CZ2
REMARK 470 TRP N 24 CZ3 CH2
REMARK 470 ASN N 25 CG OD1 ND2
REMARK 470 THR N 26 OG1 CG2
REMARK 470 VAL N 27 CG1 CG2
REMARK 470 SER N 28 OG
REMARK 470 THR N 29 OG1 CG2
REMARK 470 GLU N 53 CG CD OE1 OE2
REMARK 470 GLU N 54 CG CD OE1 OE2
REMARK 470 LEU N 55 CG CD1 CD2
REMARK 470 ARG N 56 CG CD NE CZ NH1 NH2
REMARK 470 VAL N 59 CG1 CG2
REMARK 470 GLU N 60 CG CD OE1 OE2
REMARK 470 VAL N 61 CG1 CG2
REMARK 470 LEU N 62 CG CD1 CD2
REMARK 470 ARG N 63 CG CD NE CZ NH1 NH2
REMARK 470 HIS N 65 CG ND1 CD2 CE1 NE2
REMARK 470 VAL N 70 CG1 CG2
REMARK 470 LEU N 71 CG CD1 CD2
REMARK 470 GLU N 72 CG CD OE1 OE2
REMARK 470 GLU N 73 CG CD OE1 OE2
REMARK 470 ASN N 93 CG OD1 ND2
REMARK 470 ILE N 95 CG1 CG2 CD1
REMARK 470 SER N 96 OG
REMARK 470 GLN N 97 CG CD OE1 NE2
REMARK 470 CYS N 98 SG
REMARK 470 GLU N 99 CG CD OE1 OE2
REMARK 470 ASN N 100 CG OD1 ND2
REMARK 470 SER N 101 OG
REMARK 470 CYS N 107 SG
REMARK 470 LEU N 108 CG CD1 CD2
REMARK 470 LEU N 109 CG CD1 CD2
REMARK 470 LEU N 110 CG CD1 CD2
REMARK 470 LEU N 111 CG CD1 CD2
REMARK 470 LEU N 112 CG CD1 CD2
REMARK 470 ASP N 113 CG OD1 OD2
REMARK 470 PHE N 115 CG CD1 CD2 CE1 CE2 CZ
REMARK 470 LEU N 117 CG CD1 CD2
REMARK 470 LEU N 118 CG CD1 CD2
REMARK 470 GLU N 119 CG CD OE1 OE2
REMARK 470 SER N 120 OG
REMARK 470 ARG N 121 CG CD NE CZ NH1 NH2
REMARK 470 LEU N 122 CG CD1 CD2
REMARK 470 ASP N 123 CG OD1 OD2
REMARK 470 LEU N 126 CG CD1 CD2
REMARK 470 ARG N 127 CG CD NE CZ NH1 NH2
REMARK 470 SER N 128 OG
REMARK 470 GLU N 130 CG CD OE1 OE2
REMARK 470 LEU N 131 CG CD1 CD2
REMARK 470 LEU N 132 CG CD1 CD2
REMARK 470 GLU N 133 CG CD OE1 OE2
REMARK 470 LYS N 134 CG CD CE NZ
REMARK 470 TRP N 135 CG CD1 CD2 NE1 CE2 CE3 CZ2
REMARK 470 TRP N 135 CZ3 CH2
REMARK 470 THR N 136 OG1 CG2
REMARK 470 ARG N 137 CG CD NE CZ NH1 NH2
REMARK 470 LEU N 138 CG CD1 CD2
REMARK 470 LEU N 140 CG CD1 CD2
REMARK 470 LEU N 141 CG CD1 CD2
REMARK 470 MET N 142 CG SD CE
REMARK 470 THR N 144 OG1 CG2
REMARK 470 GLN N 147 CG CD OE1 NE2
REMARK 470 SER N 164 OG
REMARK 470 THR N 165 OG1 CG2
REMARK 470 ASP N 196 CG OD1 OD2
REMARK 470 PRO N 197 CG CD
REMARK 470 GLU N 198 CG CD OE1 OE2
REMARK 470 LEU N 199 CG CD1 CD2
REMARK 470 GLU N 200 CG CD OE1 OE2
REMARK 470 LEU N 216 CG CD1 CD2
REMARK 470 GLN N 217 CG CD OE1 NE2
REMARK 470 SER N 218 OG
REMARK 470 PRO N 219 CG CD
REMARK 470 LEU N 220 CG CD1 CD2
REMARK 470 GLU N 254 CG CD OE1 OE2
REMARK 470 GLU N 294 CG CD OE1 OE2
REMARK 470 ARG N 349 CG CD NE CZ NH1 NH2
REMARK 470 THR N 443 OG1 CG2
REMARK 470 ASP N 451 CG OD1 OD2
REMARK 470 LEU N 452 CG CD1 CD2
REMARK 470 VAL N 454 CG1 CG2
REMARK 470 GLU N 455 CG CD OE1 OE2
REMARK 470 LEU N 456 CG CD1 CD2
REMARK 470 SER N 457 OG
REMARK 470 LYS N 458 CG CD CE NZ
REMARK 470 GLU N 476 CG CD OE1 OE2
REMARK 470 PRO N 477 CG CD
REMARK 470 GLU N 478 CG CD OE1 OE2
REMARK 470 ASP N 479 CG OD1 OD2
REMARK 470 TRP N 480 CG CD1 CD2 NE1 CE2 CE3 CZ2
REMARK 470 TRP N 480 CZ3 CH2
REMARK 470 VAL N 481 CG1 CG2
REMARK 470 PRO N 482 CG CD
REMARK 470 ASP N 483 CG OD1 OD2
REMARK 470 PRO N 484 CG CD
REMARK 470 VAL N 485 CG1 CG2
REMARK 470 ASP N 486 CG OD1 OD2
REMARK 470 ASP N 488 CG OD1 OD2
REMARK 470 PRO N 489 CG CD
REMARK 470 LYS N 491 CG CD CE NZ
REMARK 470 SER N 492 OG
REMARK 470 SER N 493 OG
REMARK 470 SER N 494 OG
REMARK 470 LYS N 495 CG CD CE NZ
REMARK 470 ARG N 496 CG CD NE CZ NH1 NH2
REMARK 470 ARG N 497 CG CD NE CZ NH1 NH2
REMARK 470 SER N 499 OG
REMARK 470 LYS O 27 CG CD CE NZ
REMARK 470 THR O 47 OG1 CG2
REMARK 470 GLU O 49 CG CD OE1 OE2
REMARK 470 VAL O 52 CG1 CG2
REMARK 470 THR O 122 OG1 CG2
REMARK 470 GLU O 123 CG CD OE1 OE2
REMARK 470 LYS O 168 CG CD CE NZ
REMARK 470 LYS O 169 CG CD CE NZ
REMARK 470 LYS O 229 CG CD CE NZ
REMARK 470 GLU O 452 CG CD OE1 OE2
REMARK 470 GLN O 742 CG CD OE1 NE2
REMARK 470 GLU O 743 CG CD OE1 OE2
REMARK 470 SER O 746 OG
REMARK 470 VAL O 749 CG1 CG2
REMARK 470 GLU P 69 CG CD OE1 OE2
REMARK 470 CYS P 109 SG
REMARK 470 LYS P 281 CG CD CE NZ
REMARK 470 ASP P 496 CG OD1 OD2
REMARK 470 ILE P 497 CD1
REMARK 470 SER P 499 OG
REMARK 470 CYS P 500 SG
REMARK 470 LYS R 125 CG CD CE NZ
REMARK 470 SER R 163 OG
REMARK 470 VAL R 483 CG1 CG2
REMARK 470 VAL S 319 CG1 CG2
REMARK 470 MET S 320 CG SD CE
REMARK 470 PRO S 324 CG CD
REMARK 470 TYR S 356 CG CD1 CD2 CE1 CE2 CZ OH
REMARK 470 SER S 357 OG
REMARK 470 ARG S 358 CG CD NE CZ NH1 NH2
REMARK 470 HIS S 359 CG ND1 CD2 CE1 NE2
REMARK 470 LYS S 367 CG CD CE NZ
REMARK 470 THR S 368 OG1 CG2
REMARK 470 LEU S 369 CG CD1 CD2
REMARK 470 LYS S 370 CG CD CE NZ
REMARK 470 LYS S 371 CG CD CE NZ
REMARK 470 ASN S 372 CG OD1 ND2
REMARK 470 GLU S 373 CG CD OE1 OE2
REMARK 470 LYS S 376 CG CD CE NZ
REMARK 470 SER S 420 OG
REMARK 470 ASP S 421 CG OD1 OD2
REMARK 470 LYS S 423 CG CD CE NZ
REMARK 470 LEU S 424 CG CD1 CD2
REMARK 470 LEU S 425 CG CD1 CD2
REMARK 470 LYS S 426 CG CD CE NZ
REMARK 470 SER S 428 OG
REMARK 470 CYS S 429 SG
REMARK 470 LYS S 430 CG CD CE NZ
REMARK 470 ILE S 431 CG1 CG2 CD1
REMARK 470 PRO S 433 CG CD
REMARK 470 LEU S 434 CG CD1 CD2
REMARK 470 PRO S 435 CG CD
REMARK 470 LEU T 7 CG CD1 CD2
REMARK 470 MET U 5 CG SD CE
REMARK 470 SER U 6 OG
REMARK 470 ARG U 7 CG CD NE CZ NH1 NH2
REMARK 470 ARG U 8 CG CD NE CZ NH1 NH2
REMARK 470 PRO U 9 CG CD
REMARK 470 CYS U 10 SG
REMARK 470 SER U 11 OG
REMARK 470 CYS U 12 SG
REMARK 470 LEU U 14 CG CD1 CD2
REMARK 470 ARG U 15 CG CD NE CZ NH1 NH2
REMARK 470 PRO U 16 CG CD
REMARK 470 PRO U 17 CG CD
REMARK 470 LYS W 24 CG CD CE NZ
REMARK 470 ASP W 25 CG OD1 OD2
REMARK 470 LYS X 215 CG CD CE NZ
REMARK 470 GLU X 218 CG CD OE1 OE2
REMARK 470 MET X 224 CG SD CE
REMARK 470 ASN X 225 CG OD1 ND2
REMARK 470 GLN X 228 CG CD OE1 NE2
REMARK 470 ARG X 317 CG CD NE CZ NH1 NH2
REMARK 470 GLU X 318 CG CD OE1 OE2
REMARK 470 ASN X 440 CG OD1 ND2
REMARK 470 LYS Y 215 CG CD CE NZ
REMARK 470 GLU Y 218 CG CD OE1 OE2
REMARK 470 MET Y 224 CG SD CE
REMARK 470 ASN Y 225 CG OD1 ND2
REMARK 470 GLN Y 228 CG CD OE1 NE2
REMARK 470 ARG Y 317 CG CD NE CZ NH1 NH2
REMARK 470 GLU Y 318 CG CD OE1 OE2
REMARK 470 ASN Y 440 CG OD1 ND2
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 CD GLN R 310 CD2 LEU R 338 0.85
REMARK 500 O PRO R 431 N SER R 432 0.86
REMARK 500 CE1 TYR X 355 N ASN X 385 0.94
REMARK 500 CG GLN R 310 CD2 LEU R 338 0.95
REMARK 500 CZ TYR X 355 N ASN X 385 0.96
REMARK 500 SD MET R 292 CD2 LEU R 309 1.03
REMARK 500 CE1 TYR R 189 CB GLU R 315 1.04
REMARK 500 CZ TYR X 355 C ARG X 384 1.06
REMARK 500 CD2 LEU R 267 CD1 LEU R 303 1.32
REMARK 500 CE MET R 292 NE ARG R 307 1.32
REMARK 500 OD2 ASP L 126 O LYS L 130 1.41
REMARK 500 O LEU X 359 CE LYS X 379 1.45
REMARK 500 OD1 ASN R 280 ND1 HIS R 325 1.48
REMARK 500 O GLN R 310 N GLY R 311 1.51
REMARK 500 CZ TYR R 189 CG GLU R 315 1.51
REMARK 500 CZ TYR X 355 O ARG X 384 1.52
REMARK 500 N SER O 76 OD1 ASP O 165 1.53
REMARK 500 NE2 GLN R 310 CD2 LEU R 338 1.54
REMARK 500 O VAL R 178 O SER S 327 1.57
REMARK 500 O ASP R 230 O SER R 231 1.57
REMARK 500 O PRO R 431 CA SER R 432 1.57
REMARK 500 CD PRO R 431 CB LEU R 433 1.61
REMARK 500 O VAL R 227 OD1 ASP R 230 1.61
REMARK 500 OE1 GLN R 310 CH2 TRP R 340 1.62
REMARK 500 CE1 TYR X 355 C ARG X 384 1.64
REMARK 500 OG1 THR R 434 N GLN R 435 1.67
REMARK 500 CE2 TYR X 355 O ARG X 384 1.69
REMARK 500 OH TYR R 189 CG GLU R 315 1.71
REMARK 500 OH TYR X 355 N ASN X 385 1.71
REMARK 500 OH TYR X 355 C ARG X 384 1.73
REMARK 500 CD1 TYR X 355 O ALA X 382 1.74
REMARK 500 O LYS R 429 O LEU R 433 1.75
REMARK 500 OH TYR X 355 O ARG X 384 1.77
REMARK 500 O VAL N 78 N ASN N 81 1.77
REMARK 500 CZ TYR R 189 CB GLU R 315 1.78
REMARK 500 CD1 TYR R 189 N VAL R 316 1.79
REMARK 500 CB CYS R 317 O GLY R 331 1.79
REMARK 500 CZ TYR X 355 CA ASN X 385 1.80
REMARK 500 O LEU O 222 O ASP O 226 1.81
REMARK 500 NE2 GLN R 310 CG LEU R 338 1.82
REMARK 500 OE2 GLU H 537 OE1 GLU H 568 1.82
REMARK 500 CA TYR X 355 O ALA X 382 1.83
REMARK 500 CD1 TYR R 189 CB GLU R 315 1.83
REMARK 500 CD2 TYR X 355 N MET X 386 1.83
REMARK 500 O PHE N 91 N ASN N 93 1.84
REMARK 500 CB TYR X 355 O ALA X 382 1.85
REMARK 500 O LYS X 491 OD1 ASP X 494 1.87
REMARK 500 O LYS Y 491 OD1 ASP Y 494 1.87
REMARK 500 CD GLN R 310 CG LEU R 338 1.90
REMARK 500 OD1 ASN R 280 CG HIS R 325 1.91
REMARK 500
REMARK 500 THIS ENTRY HAS 103 CLOSE CONTACTS
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 RES CSSEQI ATM2 DEVIATION
REMARK 500 TRP C 402 CB TRP C 402 CG -0.113
REMARK 500 TRP F 570 CB TRP F 570 CG -0.127
REMARK 500 TRP H 570 CB TRP H 570 CG -0.110
REMARK 500 LYS J 229 CB LYS J 229 CG -0.177
REMARK 500 TRP J 302 CB TRP J 302 CG -0.162
REMARK 500 TRP J 337 CB TRP J 337 CG -0.151
REMARK 500 LYS K 229 CB LYS K 229 CG 0.894
REMARK 500 TRP K 302 CB TRP K 302 CG -0.115
REMARK 500 TRP N 299 CE3 TRP N 299 CZ3 -0.115
REMARK 500 TRP O 346 CB TRP O 346 CG -0.142
REMARK 500 TRP P 402 CB TRP P 402 CG -0.115
REMARK 500 CYS R 208 CB CYS R 208 SG -0.392
REMARK 500 CYS R 215 CB CYS R 215 SG -0.392
REMARK 500 CYS R 223 CB CYS R 223 SG -0.392
REMARK 500 PRO R 301 CD PRO R 301 N 0.665
REMARK 500 PRO R 302 CD PRO R 302 N 0.686
REMARK 500 CYS R 317 CB CYS R 317 SG -0.393
REMARK 500 CYS R 381 CB CYS R 381 SG -0.392
REMARK 500 PRO R 392 CD PRO R 392 N 0.712
REMARK 500 CYS R 395 CB CYS R 395 SG -0.392
REMARK 500 CYS R 403 CB CYS R 403 SG -0.392
REMARK 500 PRO R 431 CD PRO R 431 N 0.753
REMARK 500 TYR X 355 CE1 TYR X 355 CZ 0.115
REMARK 500 ASN X 385 N ASN X 385 CA 0.196
REMARK 500 MET X 386 N MET X 386 CA 0.124
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 PRO A 292 N - CA - CB ANGL. DEV. = 8.1 DEGREES
REMARK 500 MET A 665 CG - SD - CE ANGL. DEV. = 11.3 DEGREES
REMARK 500 MET A1019 CG - SD - CE ANGL. DEV. = 10.3 DEGREES
REMARK 500 CYS A1074 CA - CB - SG ANGL. DEV. = -10.9 DEGREES
REMARK 500 ARG A1084 NE - CZ - NH2 ANGL. DEV. = -3.1 DEGREES
REMARK 500 MET A1203 CG - SD - CE ANGL. DEV. = -9.8 DEGREES
REMARK 500 ARG A1540 NE - CZ - NH1 ANGL. DEV. = 8.2 DEGREES
REMARK 500 ARG A1540 NE - CZ - NH2 ANGL. DEV. = -3.5 DEGREES
REMARK 500 PRO A1927 N - CA - CB ANGL. DEV. = 7.3 DEGREES
REMARK 500 PRO B 40 N - CA - CB ANGL. DEV. = 7.2 DEGREES
REMARK 500 PHE C 26 CB - CG - CD2 ANGL. DEV. = -5.0 DEGREES
REMARK 500 PHE C 26 CB - CG - CD1 ANGL. DEV. = 5.1 DEGREES
REMARK 500 ARG C 423 NE - CZ - NH1 ANGL. DEV. = 3.2 DEGREES
REMARK 500 ARG C 424 NE - CZ - NH1 ANGL. DEV. = 3.2 DEGREES
REMARK 500 LEU C 516 CA - CB - CG ANGL. DEV. = 14.7 DEGREES
REMARK 500 PRO D 23 N - CA - CB ANGL. DEV. = 7.3 DEGREES
REMARK 500 ARG F 625 NE - CZ - NH1 ANGL. DEV. = 3.0 DEGREES
REMARK 500 PRO F 768 N - CA - CB ANGL. DEV. = 8.5 DEGREES
REMARK 500 ARG H 50 NE - CZ - NH2 ANGL. DEV. = -3.1 DEGREES
REMARK 500 ARG H 467 NE - CZ - NH1 ANGL. DEV. = 3.0 DEGREES
REMARK 500 VAL I 223 CB - CA - C ANGL. DEV. = -11.7 DEGREES
REMARK 500 PRO I 489 C - N - CA ANGL. DEV. = 9.0 DEGREES
REMARK 500 ARG J 61 NE - CZ - NH1 ANGL. DEV. = 3.7 DEGREES
REMARK 500 ARG J 61 NE - CZ - NH2 ANGL. DEV. = -3.3 DEGREES
REMARK 500 PRO J 221 C - N - CD ANGL. DEV. = -15.7 DEGREES
REMARK 500 LEU J 294 CB - CG - CD2 ANGL. DEV. = 10.9 DEGREES
REMARK 500 LYS K 229 CA - CB - CG ANGL. DEV. = -29.2 DEGREES
REMARK 500 LYS K 229 CB - CG - CD ANGL. DEV. = -21.8 DEGREES
REMARK 500 ARG K 510 NE - CZ - NH1 ANGL. DEV. = 3.6 DEGREES
REMARK 500 CYS L 36 CA - CB - SG ANGL. DEV. = 6.8 DEGREES
REMARK 500 THR L 132 CB - CA - C ANGL. DEV. = -19.6 DEGREES
REMARK 500 ARG N 63 N - CA - C ANGL. DEV. = 20.1 DEGREES
REMARK 500 GLY N 64 C - N - CA ANGL. DEV. = 14.0 DEGREES
REMARK 500 ARG N 425 NE - CZ - NH1 ANGL. DEV. = 4.9 DEGREES
REMARK 500 PRO N 477 N - CA - CB ANGL. DEV. = 7.8 DEGREES
REMARK 500 PRO N 489 N - CA - CB ANGL. DEV. = 12.5 DEGREES
REMARK 500 ASP O 165 CB - CG - OD1 ANGL. DEV. = -5.5 DEGREES
REMARK 500 ARG P 344 NE - CZ - NH1 ANGL. DEV. = 3.2 DEGREES
REMARK 500 ARG P 344 NE - CZ - NH2 ANGL. DEV. = -3.3 DEGREES
REMARK 500 GLY R 45 N - CA - C ANGL. DEV. = -15.1 DEGREES
REMARK 500 ARG R 221 NH1 - CZ - NH2 ANGL. DEV. = 25.1 DEGREES
REMARK 500 ARG R 221 NE - CZ - NH1 ANGL. DEV. = -12.5 DEGREES
REMARK 500 ARG R 221 NE - CZ - NH2 ANGL. DEV. = -12.6 DEGREES
REMARK 500 SER R 226 CB - CA - C ANGL. DEV. = -14.4 DEGREES
REMARK 500 SER R 226 N - CA - CB ANGL. DEV. = 16.8 DEGREES
REMARK 500 VAL R 227 CB - CA - C ANGL. DEV. = -28.8 DEGREES
REMARK 500 VAL R 227 N - CA - CB ANGL. DEV. = 29.9 DEGREES
REMARK 500 ARG R 240 NH1 - CZ - NH2 ANGL. DEV. = 25.1 DEGREES
REMARK 500 ARG R 240 NE - CZ - NH1 ANGL. DEV. = -12.5 DEGREES
REMARK 500 ARG R 240 NE - CZ - NH2 ANGL. DEV. = -12.6 DEGREES
REMARK 500
REMARK 500 THIS ENTRY HAS 113 ANGLE DEVIATIONS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 ASN A 33 -24.35 81.69
REMARK 500 GLN A 38 77.96 -106.05
REMARK 500 GLU A 47 -55.82 -24.56
REMARK 500 ALA A 55 57.61 39.25
REMARK 500 LEU A 57 -123.01 64.44
REMARK 500 GLU A 85 18.90 59.51
REMARK 500 VAL A 87 -105.17 57.50
REMARK 500 ASP A 88 3.98 58.08
REMARK 500 ASP A 120 -33.50 79.19
REMARK 500 GLN A 125 -61.53 -136.20
REMARK 500 TYR A 185 1.86 85.30
REMARK 500 VAL A 274 -36.29 127.51
REMARK 500 LYS A 275 -138.97 67.09
REMARK 500 LYS A 429 131.05 -172.48
REMARK 500 ASP A 486 31.50 78.22
REMARK 500 ASP A 589 58.82 38.90
REMARK 500 ASN A 593 -24.81 94.61
REMARK 500 ALA A 613 -76.55 -110.02
REMARK 500 THR A 614 -27.92 85.21
REMARK 500 PRO A 630 -115.29 -69.87
REMARK 500 SER A 652 -107.28 61.42
REMARK 500 TYR A 653 -31.10 91.30
REMARK 500 MET A 668 -61.88 -101.96
REMARK 500 THR A 777 -28.67 78.37
REMARK 500 GLU A 781 -31.72 90.14
REMARK 500 LYS A 798 17.51 80.72
REMARK 500 LEU A 813 60.92 76.43
REMARK 500 MET A 857 -83.40 81.81
REMARK 500 TYR A 860 156.34 105.98
REMARK 500 CYS A 867 38.19 -88.36
REMARK 500 ARG A 980 66.99 -165.83
REMARK 500 ASP A1014 -20.42 78.39
REMARK 500 GLU A1030 -118.94 67.98
REMARK 500 HIS A1045 167.77 75.51
REMARK 500 PRO A1055 56.86 -54.68
REMARK 500 GLU A1098 156.62 -44.59
REMARK 500 PRO A1099 -72.58 -78.14
REMARK 500 LEU A1100 -73.74 -141.37
REMARK 500 ILE A1125 147.99 69.14
REMARK 500 MET A1131 143.40 -38.53
REMARK 500 THR A1132 -14.65 83.94
REMARK 500 LYS A1164 -3.09 57.66
REMARK 500 LEU A1217 64.25 30.89
REMARK 500 MET A1220 61.49 70.99
REMARK 500 THR A1239 172.24 178.55
REMARK 500 GLU A1284 -132.44 46.49
REMARK 500 TYR A1287 7.11 96.29
REMARK 500 CYS A1288 50.66 -105.41
REMARK 500 LEU A1307 76.72 15.46
REMARK 500 ILE A1314 -106.42 45.41
REMARK 500
REMARK 500 THIS ENTRY HAS 373 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500 MODEL OMEGA
REMARK 500 MET A 11 ILE A 12 -144.31
REMARK 500 ALA A 14 ARG A 15 -149.26
REMARK 500 ILE A 83 GLY A 84 139.31
REMARK 500 ASP A 86 VAL A 87 148.63
REMARK 500 GLN A 124 GLN A 125 -149.85
REMARK 500 GLU A 840 PRO A 841 -149.36
REMARK 500 PRO A 859 TYR A 860 141.42
REMARK 500 GLY A 1282 PRO A 1283 148.86
REMARK 500 MET A 1652 ALA A 1653 -147.39
REMARK 500 GLY I 658 ARG I 659 -146.67
REMARK 500 PHE I 727 ARG I 728 149.53
REMARK 500 ILE J 220 PRO J 221 -124.20
REMARK 500 LEU N 62 ARG N 63 134.97
REMARK 500 ARG N 63 GLY N 64 31.42
REMARK 500 GLU N 77 VAL N 78 128.10
REMARK 500 VAL N 78 LEU N 79 144.08
REMARK 500 GLN N 147 GLY N 148 149.68
REMARK 500 PHE N 162 PHE N 163 44.66
REMARK 500 SER N 164 THR N 165 -44.41
REMARK 500 GLY N 201 GLU N 202 -130.53
REMARK 500 GLU N 280 TYR N 281 49.79
REMARK 500 TYR N 281 GLU N 282 -121.54
REMARK 500 GLU N 282 ARG N 283 148.49
REMARK 500 LEU N 321 ARG N 322 149.21
REMARK 500 PHE N 351 PRO N 352 140.11
REMARK 500 PRO N 352 ASP N 353 -135.67
REMARK 500 ASP N 353 SER N 354 -142.50
REMARK 500 ARG N 367 THR N 368 -136.92
REMARK 500 LEU N 387 HIS N 388 -132.86
REMARK 500 CYS N 394 ASP N 395 98.07
REMARK 500 ASP N 395 ILE N 396 137.31
REMARK 500 PRO N 477 GLU N 478 -33.21
REMARK 500 PRO N 482 ASP N 483 -142.62
REMARK 500 PRO N 484 VAL N 485 37.58
REMARK 500 VAL N 485 ASP N 486 138.13
REMARK 500 ALA N 487 ASP N 488 132.00
REMARK 500 LYS N 495 ARG N 496 142.45
REMARK 500 TYR N 509 GLY N 510 -37.36
REMARK 500 PHE R 48 ILE R 49 132.89
REMARK 500 SER R 131 LEU R 132 30.43
REMARK 500 PRO R 431 SER R 432 42.66
REMARK 500 ALA T 3 ALA T 4 -143.66
REMARK 500 ASN X 385 MET X 386 148.65
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY
REMARK 500
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 500 I=INSERTION CODE).
REMARK 500
REMARK 500 M RES CSSEQI ANGLE
REMARK 500 GLN R 310 -46.95
REMARK 500 PRO R 431 -66.66
REMARK 500
REMARK 500 REMARK: NULL
REMARK 620
REMARK 620 METAL COORDINATION
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN B 101 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS B 59 SG
REMARK 620 2 CYS B 23 SG 148.0
REMARK 620 3 CYS B 26 SG 96.4 106.0
REMARK 620 N 1 2
REMARK 620
REMARK 620 COORDINATION ANGLES FOR: M RES CSSEQI METAL
REMARK 620 ZN B 102 ZN
REMARK 620 N RES CSSEQI ATOM
REMARK 620 1 CYS B 76 SG
REMARK 620 2 CYS B 73 SG 107.1
REMARK 620 3 HIS B 53 ND1 111.9 125.1
REMARK 620 N 1 2
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN B 101
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN B 102
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN B 103
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN S 601
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE ZN S 602
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-2924 RELATED DB: EMDB
DBREF 4UI9 A 1 1947 UNP Q9H1A4 APC1_HUMAN 1 1944
DBREF 4UI9 B 1 84 UNP Q9NYG5 APC11_HUMAN 1 84
DBREF 4UI9 C 7 597 UNP Q9UJX2 CDC23_HUMAN 7 597
DBREF 4UI9 D 1 121 UNP P60006 APC15_HUMAN 1 121
DBREF 4UI9 E 1 110 UNP Q96DE5 APC16_HUMAN 1 110
DBREF 4UI9 F 1 861 UNP P30260 CDC27_HUMAN 1 824
DBREF 4UI9 G 1 85 UNP Q8NHZ8 CDC26_HUMAN 1 85
DBREF 4UI9 H 1 828 UNP P30260 CDC27_HUMAN 1 824
DBREF 4UI9 I 1 808 UNP Q9UJX5 APC4_HUMAN 1 808
DBREF 4UI9 J 1 620 UNP Q13042 CDC16_HUMAN 1 620
DBREF 4UI9 K 1 620 UNP Q13042 CDC16_HUMAN 1 620
DBREF 4UI9 L 2 184 UNP Q9UM13 APC10_HUMAN 2 185
DBREF 4UI9 M 1 74 UNP Q9BS18 APC13_HUMAN 1 74
DBREF 4UI9 N 1 822 UNP Q9UJX6 ANC2_HUMAN 1 822
DBREF 4UI9 O 1 755 UNP Q9UJX4 APC5_HUMAN 1 755
DBREF 4UI9 P 7 597 UNP Q9UJX2 CDC23_HUMAN 7 597
DBREF 4UI9 R 1 493 UNP Q9UM11 FZR_HUMAN 1 493
DBREF 4UI9 S 1 447 UNP Q9UKT4 FBX5_HUMAN 1 447
DBREF 4UI9 T 1 21 PDB 4UI9 4UI9 1 21
DBREF 4UI9 U 5 28 PDB 4UI9 4UI9 5 28
DBREF 4UI9 W 1 85 UNP Q8NHZ8 CDC26_HUMAN 1 85
DBREF 4UI9 X 35 599 UNP Q9UJX3 APC7_HUMAN 35 599
DBREF 4UI9 Y 35 599 UNP Q9UJX3 APC7_HUMAN 35 599
SEQADV 4UI9 PHE A 291 UNP Q9H1A4 THR 291 CONFLICT
SEQADV 4UI9 ILE A 940 UNP Q9H1A4 THR 940 CONFLICT
SEQADV 4UI9 GLU A 1059 UNP Q9H1A4 ASP 1059 CONFLICT
SEQADV 4UI9 LEU A 1358 UNP Q9H1A4 ILE 1358 CONFLICT
SEQADV 4UI9 LEU A 1637 UNP Q9H1A4 THR 1637 CONFLICT
SEQADV 4UI9 PRO A 1880 UNP Q9H1A4 LEU 1877 CONFLICT
SEQADV 4UI9 LEU A 1881 UNP Q9H1A4 GLU 1878 CONFLICT
SEQADV 4UI9 LEU B 13 UNP Q9NYG5 THR 13 CONFLICT
SEQADV 4UI9 LEU C 161 UNP Q9UJX2 LYS 161 CONFLICT
SEQADV 4UI9 TYR D 5 UNP P60006 PHE 5 CONFLICT
SEQADV 4UI9 GLU F 403 UNP P30260 LYS 403 CONFLICT
SEQADV 4UI9 SER F 475 UNP P30260 ALA 475 CONFLICT
SEQADV 4UI9 SER F 484 UNP P30260 ALA 484 CONFLICT
SEQADV 4UI9 GLU G 14 UNP Q8NHZ8 ASP 14 CONFLICT
SEQADV 4UI9 GLU H 403 UNP P30260 LYS 403 CONFLICT
SEQADV 4UI9 SER H 475 UNP P30260 ALA 475 CONFLICT
SEQADV 4UI9 SER H 484 UNP P30260 ALA 484 CONFLICT
SEQADV 4UI9 ASP I 430 UNP Q9UJX5 GLU 430 CONFLICT
SEQADV 4UI9 ASN J 225 UNP Q13042 ASP 225 CONFLICT
SEQADV 4UI9 GLU J 228 UNP Q13042 GLN 228 CONFLICT
SEQADV 4UI9 LYS J 229 UNP Q13042 GLU 229 CONFLICT
SEQADV 4UI9 GLU K 228 UNP Q13042 GLN 228 CONFLICT
SEQADV 4UI9 LYS K 229 UNP Q13042 GLU 229 CONFLICT
SEQADV 4UI9 LYS K 265 UNP Q13042 ALA 265 CONFLICT
SEQADV 4UI9 L UNP Q9UM13 GLU 163 DELETION
SEQADV 4UI9 ILE N 410 UNP Q9UJX6 LEU 410 CONFLICT
SEQADV 4UI9 SER O 42 UNP Q9UJX4 ASN 42 CONFLICT
SEQADV 4UI9 VAL O 55 UNP Q9UJX4 MET 55 CONFLICT
SEQADV 4UI9 GLN O 63 UNP Q9UJX4 LEU 63 CONFLICT
SEQADV 4UI9 VAL O 75 UNP Q9UJX4 LEU 75 CONFLICT
SEQADV 4UI9 LEU O 79 UNP Q9UJX4 TYR 79 CONFLICT
SEQADV 4UI9 SER O 164 UNP Q9UJX4 ASN 164 CONFLICT
SEQADV 4UI9 ASP O 165 UNP Q9UJX4 GLY 165 CONFLICT
SEQADV 4UI9 ASN O 167 UNP Q9UJX4 INSERTION
SEQADV 4UI9 LEU P 161 UNP Q9UJX2 LYS 161 CONFLICT
SEQADV 4UI9 ILE S 323 UNP Q9UKT4 THR 323 CONFLICT
SEQADV 4UI9 LYS S 326 UNP Q9UKT4 ALA 326 CONFLICT
SEQADV 4UI9 LEU X 63 UNP Q9UJX3 MET 63 CONFLICT
SEQADV 4UI9 LEU X 142 UNP Q9UJX3 MET 142 CONFLICT
SEQADV 4UI9 VAL X 148 UNP Q9UJX3 MET 148 CONFLICT
SEQADV 4UI9 ASN X 466 UNP Q9UJX3 ASP 466 CONFLICT
SEQADV 4UI9 GLU X 472 UNP Q9UJX3 ARG 472 CONFLICT
SEQADV 4UI9 LEU Y 63 UNP Q9UJX3 MET 63 CONFLICT
SEQADV 4UI9 LEU Y 142 UNP Q9UJX3 MET 142 CONFLICT
SEQADV 4UI9 VAL Y 148 UNP Q9UJX3 MET 148 CONFLICT
SEQADV 4UI9 ASN Y 466 UNP Q9UJX3 ASP 466 CONFLICT
SEQADV 4UI9 GLU Y 472 UNP Q9UJX3 ARG 472 CONFLICT
SEQRES 1 A 1944 MET SER ASN PHE TYR GLU GLU ARG THR THR MET ILE ALA
SEQRES 2 A 1944 ALA ARG ASP LEU GLN GLU PHE VAL PRO PHE GLY ARG ASP
SEQRES 3 A 1944 HIS CYS LYS HIS HIS PRO ASN ALA LEU ASN LEU GLN LEU
SEQRES 4 A 1944 ARG GLN LEU GLN PRO ALA SER GLU LEU TRP SER SER ASP
SEQRES 5 A 1944 GLY ALA ALA GLY LEU VAL GLY SER LEU GLN GLU VAL THR
SEQRES 6 A 1944 ILE HIS GLU LYS GLN LYS GLU SER TRP GLN LEU ARG LYS
SEQRES 7 A 1944 GLY VAL SER GLU ILE GLY GLU ASP VAL ASP TYR ASP GLU
SEQRES 8 A 1944 GLU LEU TYR VAL ALA GLY ASN MET VAL ILE TRP SER LYS
SEQRES 9 A 1944 GLY SER LYS SER GLN ALA LEU ALA VAL TYR LYS ALA PHE
SEQRES 10 A 1944 THR VAL ASP SER PRO VAL GLN GLN ALA LEU TRP CYS ASP
SEQRES 11 A 1944 PHE ILE ILE SER GLN ASP LYS SER GLU LYS ALA TYR SER
SEQRES 12 A 1944 SER ASN GLU VAL GLU LYS CYS ILE CYS ILE LEU GLN SER
SEQRES 13 A 1944 SER CYS ILE ASN MET HIS SER ILE GLU GLY LYS ASP TYR
SEQRES 14 A 1944 ILE ALA SER LEU PRO PHE GLN VAL ALA ASN VAL TRP PRO
SEQRES 15 A 1944 THR LYS TYR GLY LEU LEU PHE GLU ARG SER ALA SER SER
SEQRES 16 A 1944 HIS GLU VAL PRO PRO GLY SER PRO ARG GLU PRO LEU PRO
SEQRES 17 A 1944 THR MET PHE SER MET LEU HIS PRO LEU ASP GLU ILE THR
SEQRES 18 A 1944 PRO LEU VAL CYS LYS SER GLY SER LEU PHE GLY SER SER
SEQRES 19 A 1944 ARG VAL GLN TYR VAL VAL ASP HIS ALA MET LYS ILE VAL
SEQRES 20 A 1944 PHE LEU ASN THR ASP PRO SER ILE VAL MET THR TYR ASP
SEQRES 21 A 1944 ALA VAL GLN ASN VAL HIS SER VAL TRP THR LEU ARG ARG
SEQRES 22 A 1944 VAL LYS SER GLU GLU GLU ASN VAL VAL LEU LYS PHE SER
SEQRES 23 A 1944 GLU GLN GLY GLY PHE PRO GLN ASN VAL ALA THR SER SER
SEQRES 24 A 1944 SER LEU THR ALA HIS LEU ARG SER LEU SER LYS GLY ASP
SEQRES 25 A 1944 SER PRO VAL THR SER PRO PHE GLN ASN TYR SER SER ILE
SEQRES 26 A 1944 HIS SER GLN SER ARG SER THR SER SER PRO SER LEU HIS
SEQRES 27 A 1944 SER ARG SER PRO SER ILE SER ASN MET ALA ALA LEU SER
SEQRES 28 A 1944 ARG ALA HIS SER PRO ALA LEU GLY VAL HIS SER PHE SER
SEQRES 29 A 1944 GLY VAL GLN ARG PHE ASN ILE SER SER HIS ASN GLN SER
SEQRES 30 A 1944 PRO LYS ARG HIS SER ILE SER HIS SER PRO ASN SER ASN
SEQRES 31 A 1944 SER ASN GLY SER PHE LEU ALA PRO GLU THR GLU PRO ILE
SEQRES 32 A 1944 VAL PRO GLU LEU CYS ILE ASP HIS LEU TRP THR GLU THR
SEQRES 33 A 1944 ILE THR ASN ILE ARG GLU LYS ASN SER GLN ALA SER LYS
SEQRES 34 A 1944 VAL PHE ILE THR SER ASP LEU CYS GLY GLN LYS PHE LEU
SEQRES 35 A 1944 CYS PHE LEU VAL GLU SER GLN LEU GLN LEU ARG CYS VAL
SEQRES 36 A 1944 LYS PHE GLN GLU SER ASN ASP LYS THR GLN LEU ILE PHE
SEQRES 37 A 1944 GLY SER VAL THR ASN ILE PRO ALA LYS ASP ALA ALA PRO
SEQRES 38 A 1944 VAL GLU LYS ILE ASP THR MET LEU VAL LEU GLU GLY SER
SEQRES 39 A 1944 GLY ASN LEU VAL LEU TYR THR GLY VAL VAL ARG VAL GLY
SEQRES 40 A 1944 LYS VAL PHE ILE PRO GLY LEU PRO ALA PRO SER LEU THR
SEQRES 41 A 1944 MET SER ASN THR MET PRO ARG PRO SER THR PRO LEU ASP
SEQRES 42 A 1944 GLY VAL SER THR PRO LYS PRO LEU SER LYS LEU LEU GLY
SEQRES 43 A 1944 SER LEU ASP GLU VAL VAL LEU LEU SER PRO VAL PRO GLU
SEQRES 44 A 1944 LEU ARG ASP SER SER LYS LEU HIS ASP SER LEU TYR ASN
SEQRES 45 A 1944 GLU ASP CYS THR PHE GLN GLN LEU GLY THR TYR ILE HIS
SEQRES 46 A 1944 SER ILE ARG ASP PRO VAL HIS ASN ARG VAL THR LEU GLU
SEQRES 47 A 1944 LEU SER ASN GLY SER MET VAL ARG ILE THR ILE PRO GLU
SEQRES 48 A 1944 ILE ALA THR SER GLU LEU VAL GLN THR CYS LEU GLN ALA
SEQRES 49 A 1944 ILE LYS PHE ILE LEU PRO LYS GLU ILE ALA VAL GLN MET
SEQRES 50 A 1944 LEU VAL LYS TRP TYR ASN VAL HIS SER ALA PRO GLY GLY
SEQRES 51 A 1944 PRO SER TYR HIS SER GLU TRP ASN LEU PHE VAL THR CYS
SEQRES 52 A 1944 LEU MET ASN MET MET GLY TYR ASN THR ASP ARG LEU ALA
SEQRES 53 A 1944 TRP THR ARG ASN PHE ASP PHE GLU GLY SER LEU SER PRO
SEQRES 54 A 1944 VAL ILE ALA PRO LYS LYS ALA ARG PRO SER GLU THR GLY
SEQRES 55 A 1944 SER ASP ASP ASP TRP GLU TYR LEU LEU ASN SER ASP TYR
SEQRES 56 A 1944 HIS GLN ASN VAL GLU SER HIS LEU LEU ASN ARG SER LEU
SEQRES 57 A 1944 CYS LEU SER PRO SER GLU ALA SER GLN MET LYS ASP GLU
SEQRES 58 A 1944 ASP PHE SER GLN ASN LEU SER LEU ASP SER SER THR LEU
SEQRES 59 A 1944 LEU PHE THR HIS ILE PRO ALA ILE PHE PHE VAL LEU HIS
SEQRES 60 A 1944 LEU VAL TYR GLU GLU LEU LYS LEU ASN THR LEU MET GLY
SEQRES 61 A 1944 GLU GLY ILE CYS SER LEU VAL GLU LEU LEU VAL GLN LEU
SEQRES 62 A 1944 ALA ARG ASP LEU LYS LEU GLY PRO TYR VAL ASP HIS TYR
SEQRES 63 A 1944 TYR ARG ASP TYR PRO THR LEU VAL ARG THR THR GLY GLN
SEQRES 64 A 1944 VAL CYS THR ILE ASP PRO GLY GLN THR GLY PHE MET HIS
SEQRES 65 A 1944 HIS PRO SER PHE PHE THR SER GLU PRO PRO SER ILE TYR
SEQRES 66 A 1944 GLN TRP VAL SER SER CYS LEU LYS GLY GLU GLY MET PRO
SEQRES 67 A 1944 PRO TYR PRO TYR LEU PRO GLY ILE CYS GLU ARG SER ARG
SEQRES 68 A 1944 LEU VAL VAL LEU SER ILE ALA LEU TYR ILE LEU GLY ASP
SEQRES 69 A 1944 GLU SER LEU VAL SER ASP GLU SER SER GLN TYR LEU THR
SEQRES 70 A 1944 ARG ILE THR ILE ALA PRO GLN LYS LEU GLN VAL GLU GLN
SEQRES 71 A 1944 GLU GLU ASN ARG PHE SER PHE ARG HIS SER THR SER VAL
SEQRES 72 A 1944 SER SER LEU ALA GLU ARG LEU VAL VAL TRP MET THR ASN
SEQRES 73 A 1944 VAL GLY PHE ILE LEU ARG ASP LEU GLU THR LEU PRO PHE
SEQRES 74 A 1944 GLY ILE ALA LEU PRO ILE ARG ASP ALA ILE TYR HIS CYS
SEQRES 75 A 1944 ARG GLU GLN PRO ALA SER ASP TRP PRO GLU ALA VAL CYS
SEQRES 76 A 1944 LEU LEU ILE GLY ARG GLN ASP LEU SER LYS GLN ALA CYS
SEQRES 77 A 1944 GLU GLY ASN LEU PRO LYS GLY LYS SER VAL LEU SER SER
SEQRES 78 A 1944 ASP VAL PRO SER GLY THR GLU THR GLU GLU GLU ASP ASP
SEQRES 79 A 1944 GLY MET ASN ASP MET ASN HIS GLU VAL MET SER LEU ILE
SEQRES 80 A 1944 TRP SER GLU ASP LEU ARG VAL GLN ASP VAL ARG ARG LEU
SEQRES 81 A 1944 LEU GLN SER ALA HIS PRO VAL ARG VAL ASN VAL VAL GLN
SEQRES 82 A 1944 TYR PRO GLU LEU SER GLU HIS GLU PHE ILE GLU GLU LYS
SEQRES 83 A 1944 GLU ASN ARG LEU LEU GLN LEU CYS GLN ARG THR MET ALA
SEQRES 84 A 1944 LEU PRO VAL GLY ARG GLY MET PHE THR LEU PHE SER TYR
SEQRES 85 A 1944 HIS PRO VAL PRO THR GLU PRO LEU PRO ILE PRO LYS LEU
SEQRES 86 A 1944 ASN LEU THR GLY ARG ALA PRO PRO ARG ASN THR THR VAL
SEQRES 87 A 1944 ASP LEU ASN SER GLY ASN ILE ASP VAL PRO PRO ASN MET
SEQRES 88 A 1944 THR SER TRP ALA SER PHE HIS ASN GLY VAL ALA ALA GLY
SEQRES 89 A 1944 LEU LYS ILE ALA PRO ALA SER GLN ILE ASP SER ALA TRP
SEQRES 90 A 1944 ILE VAL TYR ASN LYS PRO LYS HIS ALA GLU LEU ALA ASN
SEQRES 91 A 1944 GLU TYR ALA GLY PHE LEU MET ALA LEU GLY LEU ASN GLY
SEQRES 92 A 1944 HIS LEU THR LYS LEU ALA THR LEU ASN ILE HIS ASP TYR
SEQRES 93 A 1944 LEU THR LYS GLY HIS GLU MET THR SER ILE GLY LEU LEU
SEQRES 94 A 1944 LEU GLY VAL SER ALA ALA LYS LEU GLY THR MET ASP MET
SEQRES 95 A 1944 SER ILE THR ARG LEU LEU SER ILE HIS ILE PRO ALA LEU
SEQRES 96 A 1944 LEU PRO PRO THR SER THR GLU LEU ASP VAL PRO HIS ASN
SEQRES 97 A 1944 VAL GLN VAL ALA ALA VAL VAL GLY ILE GLY LEU VAL TYR
SEQRES 98 A 1944 GLN GLY THR ALA HIS ARG HIS THR ALA GLU VAL LEU LEU
SEQRES 99 A 1944 ALA GLU ILE GLY ARG PRO PRO GLY PRO GLU MET GLU TYR
SEQRES 100 A 1944 CYS THR ASP ARG GLU SER TYR SER LEU ALA ALA GLY LEU
SEQRES 101 A 1944 ALA LEU GLY MET VAL CYS LEU GLY HIS GLY SER ASN LEU
SEQRES 102 A 1944 ILE GLY MET SER ASP LEU ASN VAL PRO GLU GLN LEU TYR
SEQRES 103 A 1944 GLN TYR MET VAL GLY GLY HIS ARG ARG PHE GLN THR GLY
SEQRES 104 A 1944 MET HIS ARG GLU LYS HIS LYS SER PRO SER TYR GLN ILE
SEQRES 105 A 1944 LYS GLU GLY ASP THR LEU ASN VAL ASP VAL THR CYS PRO
SEQRES 106 A 1944 GLY ALA THR LEU ALA LEU ALA MET ILE TYR LEU LYS THR
SEQRES 107 A 1944 ASN ASN ARG SER ILE ALA ASP TRP LEU ARG ALA PRO ASP
SEQRES 108 A 1944 THR MET TYR LEU LEU ASP PHE VAL LYS PRO GLU PHE LEU
SEQRES 109 A 1944 LEU LEU ARG THR LEU ALA ARG CYS LEU ILE LEU TRP ASP
SEQRES 110 A 1944 ASP ILE LEU PRO ASN SER LYS TRP VAL ASP SER ASN VAL
SEQRES 111 A 1944 PRO GLN ILE ILE ARG GLU ASN SER ILE SER LEU SER GLU
SEQRES 112 A 1944 ILE GLU LEU PRO CYS SER GLU ASP LEU ASN LEU GLU THR
SEQRES 113 A 1944 LEU SER GLN ALA HIS VAL TYR ILE ILE ALA GLY ALA CYS
SEQRES 114 A 1944 LEU SER LEU GLY PHE ARG PHE ALA GLY SER GLU ASN LEU
SEQRES 115 A 1944 SER ALA PHE ASN CYS LEU HIS LYS PHE ALA LYS ASP PHE
SEQRES 116 A 1944 MET THR TYR LEU SER ALA PRO ASN ALA SER VAL THR GLY
SEQRES 117 A 1944 PRO HIS ASN LEU GLU THR CYS LEU SER VAL VAL LEU LEU
SEQRES 118 A 1944 SER LEU ALA MET VAL MET ALA GLY SER GLY ASN LEU LYS
SEQRES 119 A 1944 VAL LEU GLN LEU CYS ARG PHE LEU HIS MET LYS THR GLY
SEQRES 120 A 1944 GLY GLU MET ASN TYR GLY PHE HIS LEU ALA HIS HIS MET
SEQRES 121 A 1944 ALA LEU GLY LEU LEU PHE LEU GLY GLY GLY ARG TYR SER
SEQRES 122 A 1944 LEU SER THR SER ASN SER SER ILE ALA ALA LEU LEU CYS
SEQRES 123 A 1944 ALA LEU TYR PRO HIS PHE PRO ALA HIS SER THR ASP ASN
SEQRES 124 A 1944 ARG TYR HIS LEU GLN ALA LEU ARG HIS LEU TYR VAL LEU
SEQRES 125 A 1944 ALA ALA GLU PRO ARG LEU LEU VAL PRO VAL ASP VAL ASP
SEQRES 126 A 1944 THR ASN THR PRO CYS TYR ALA LEU LEU GLU VAL LEU TYR
SEQRES 127 A 1944 LYS GLY THR GLN TRP TYR GLU GLN THR LYS GLU GLU LEU
SEQRES 128 A 1944 MET ALA PRO THR LEU LEU PRO GLU LEU HIS LEU LEU LYS
SEQRES 129 A 1944 GLN ILE LYS VAL LYS GLY PRO ARG TYR TRP GLU LEU LEU
SEQRES 130 A 1944 ILE ASP LEU SER LYS GLY THR GLN HIS LEU LYS SER ILE
SEQRES 131 A 1944 LEU SER LYS ASP GLY VAL LEU TYR VAL LYS LEU ARG ALA
SEQRES 132 A 1944 GLY GLN LEU SER TYR LYS GLU ASP PRO MET GLY TRP GLN
SEQRES 133 A 1944 SER LEU LEU ALA GLN THR VAL ALA ASN ARG ASN SER GLU
SEQRES 134 A 1944 ALA ARG ALA PHE LYS PRO GLU THR ILE SER ALA PHE THR
SEQRES 135 A 1944 SER ASP PRO ALA LEU LEU SER PHE ALA GLU TYR PHE CYS
SEQRES 136 A 1944 LYS PRO THR VAL ASN MET GLY GLN LYS GLN GLU ILE LEU
SEQRES 137 A 1944 ASP LEU PHE SER SER VAL LEU TYR GLU CYS VAL THR GLN
SEQRES 138 A 1944 GLU THR PRO GLU MET LEU PRO ALA TYR ILE ALA MET ASP
SEQRES 139 A 1944 GLN ALA ILE ARG ARG LEU GLY ARG ARG GLU MET SER GLU
SEQRES 140 A 1944 THR SER GLU LEU TRP GLN ILE LYS LEU VAL LEU GLU PHE
SEQRES 141 A 1944 PHE SER SER ARG SER HIS GLN GLU ARG LEU GLN ASN HIS
SEQRES 142 A 1944 PRO LYS ARG GLY LEU PHE MET ASN SER GLU PHE LEU PRO
SEQRES 143 A 1944 VAL VAL LYS CYS THR ILE ASP ASN THR LEU ASP GLN TRP
SEQRES 144 A 1944 LEU GLN VAL GLY GLY ASP MET CYS VAL HIS ALA TYR LEU
SEQRES 145 A 1944 SER GLY GLN PRO PRO LEU GLU SER GLN LEU SER MET LEU
SEQRES 146 A 1944 ALA CYS PHE LEU VAL TYR HIS SER VAL PRO ALA PRO GLN
SEQRES 147 A 1944 HIS LEU PRO PRO ILE GLY LEU GLU GLY SER THR SER PHE
SEQRES 148 A 1944 ALA GLU LEU LEU PHE LYS PHE LYS GLN LEU LYS MET PRO
SEQRES 149 A 1944 VAL ARG ALA LEU LEU ARG LEU ALA PRO LEU LEU LEU GLY
SEQRES 150 A 1944 ASN PRO GLN PRO MET VAL MET
SEQRES 1 B 84 MET LYS VAL LYS ILE LYS CYS TRP ASN GLY VAL ALA LEU
SEQRES 2 B 84 TRP LEU TRP VAL ALA ASN ASP GLU ASN CYS GLY ILE CYS
SEQRES 3 B 84 ARG MET ALA PHE ASN GLY CYS CYS PRO ASP CYS LYS VAL
SEQRES 4 B 84 PRO GLY ASP ASP CYS PRO LEU VAL TRP GLY GLN CYS SER
SEQRES 5 B 84 HIS CYS PHE HIS MET HIS CYS ILE LEU LYS TRP LEU HIS
SEQRES 6 B 84 ALA GLN GLN VAL GLN GLN HIS CYS PRO MET CYS ARG GLN
SEQRES 7 B 84 GLU TRP LYS PHE LYS GLU
SEQRES 1 C 591 MET VAL PRO VAL ALA VAL THR ALA ALA VAL ALA PRO VAL
SEQRES 2 C 591 LEU SER ILE ASN SER ASP PHE SER ASP LEU ARG GLU ILE
SEQRES 3 C 591 LYS LYS GLN LEU LEU LEU ILE ALA GLY LEU THR ARG GLU
SEQRES 4 C 591 ARG GLY LEU LEU HIS SER SER LYS TRP SER ALA GLU LEU
SEQRES 5 C 591 ALA PHE SER LEU PRO ALA LEU PRO LEU ALA GLU LEU GLN
SEQRES 6 C 591 PRO PRO PRO PRO ILE THR GLU GLU ASP ALA GLN ASP MET
SEQRES 7 C 591 ASP ALA TYR THR LEU ALA LYS ALA TYR PHE ASP VAL LYS
SEQRES 8 C 591 GLU TYR ASP ARG ALA ALA HIS PHE LEU HIS GLY CYS ASN
SEQRES 9 C 591 SER LYS LYS ALA TYR PHE LEU TYR MET TYR SER ARG TYR
SEQRES 10 C 591 LEU SER GLY GLU LYS LYS LYS ASP ASP GLU THR VAL ASP
SEQRES 11 C 591 SER LEU GLY PRO LEU GLU LYS GLY GLN VAL LYS ASN GLU
SEQRES 12 C 591 ALA LEU ARG GLU LEU ARG VAL GLU LEU SER LYS LEU HIS
SEQRES 13 C 591 GLN ALA ARG GLU LEU ASP GLY PHE GLY LEU TYR LEU TYR
SEQRES 14 C 591 GLY VAL VAL LEU ARG LYS LEU ASP LEU VAL LYS GLU ALA
SEQRES 15 C 591 ILE ASP VAL PHE VAL GLU ALA THR HIS VAL LEU PRO LEU
SEQRES 16 C 591 HIS TRP GLY ALA TRP LEU GLU LEU CYS ASN LEU ILE THR
SEQRES 17 C 591 ASP LYS GLU MET LEU LYS PHE LEU SER LEU PRO ASP THR
SEQRES 18 C 591 TRP MET LYS GLU PHE PHE LEU ALA HIS ILE TYR THR GLU
SEQRES 19 C 591 LEU GLN LEU ILE GLU GLU ALA LEU GLN LYS TYR GLN ASN
SEQRES 20 C 591 LEU ILE ASP VAL GLY PHE SER LYS SER SER TYR ILE VAL
SEQRES 21 C 591 SER GLN ILE ALA VAL ALA TYR HIS ASN ILE ARG ASP ILE
SEQRES 22 C 591 ASP LYS ALA LEU SER ILE PHE ASN GLU LEU ARG LYS GLN
SEQRES 23 C 591 ASP PRO TYR ARG ILE GLU ASN MET ASP THR PHE SER ASN
SEQRES 24 C 591 LEU LEU TYR VAL ARG SER MET LYS SER GLU LEU SER TYR
SEQRES 25 C 591 LEU ALA HIS ASN LEU CYS GLU ILE ASP LYS TYR ARG VAL
SEQRES 26 C 591 GLU THR CYS CYS VAL ILE GLY ASN TYR TYR SER LEU ARG
SEQRES 27 C 591 SER GLN HIS GLU LYS ALA ALA LEU TYR PHE GLN ARG ALA
SEQRES 28 C 591 LEU LYS LEU ASN PRO ARG TYR LEU GLY ALA TRP THR LEU
SEQRES 29 C 591 MET GLY HIS GLU TYR MET GLU MET LYS ASN THR SER ALA
SEQRES 30 C 591 ALA ILE GLN ALA TYR ARG HIS ALA ILE GLU VAL ASN LYS
SEQRES 31 C 591 ARG ASP TYR ARG ALA TRP TYR GLY LEU GLY GLN THR TYR
SEQRES 32 C 591 GLU ILE LEU LYS MET PRO PHE TYR CYS LEU TYR TYR TYR
SEQRES 33 C 591 ARG ARG ALA HIS GLN LEU ARG PRO ASN ASP SER ARG MET
SEQRES 34 C 591 LEU VAL ALA LEU GLY GLU CYS TYR GLU LYS LEU ASN GLN
SEQRES 35 C 591 LEU VAL GLU ALA LYS LYS CYS TYR TRP ARG ALA TYR ALA
SEQRES 36 C 591 VAL GLY ASP VAL GLU LYS MET ALA LEU VAL LYS LEU ALA
SEQRES 37 C 591 LYS LEU HIS GLU GLN LEU THR GLU SER GLU GLN ALA ALA
SEQRES 38 C 591 GLN CYS TYR ILE LYS TYR ILE GLN ASP ILE TYR SER CYS
SEQRES 39 C 591 GLY GLU ILE VAL GLU HIS LEU GLU GLU SER THR ALA PHE
SEQRES 40 C 591 ARG TYR LEU ALA GLN TYR TYR PHE LYS CYS LYS LEU TRP
SEQRES 41 C 591 ASP GLU ALA SER THR CYS ALA GLN LYS CYS CYS ALA PHE
SEQRES 42 C 591 ASN ASP THR ARG GLU GLU GLY LYS ALA LEU LEU ARG GLN
SEQRES 43 C 591 ILE LEU GLN LEU ARG ASN GLN GLY GLU THR PRO THR THR
SEQRES 44 C 591 GLU VAL PRO ALA PRO PHE PHE LEU PRO ALA SER LEU SER
SEQRES 45 C 591 ALA ASN ASN THR PRO THR ARG ARG VAL SER PRO LEU ASN
SEQRES 46 C 591 LEU SER SER VAL THR PRO
SEQRES 1 D 121 MET SER THR LEU TYR PRO SER LEU PHE PRO ARG VAL THR
SEQRES 2 D 121 GLU THR LEU TRP PHE ASN LEU ASP ARG PRO CYS VAL GLU
SEQRES 3 D 121 GLU THR GLU LEU GLN GLN GLN GLU GLN GLN HIS GLN ALA
SEQRES 4 D 121 TRP LEU GLN SER ILE ALA GLU LYS ASP ASN ASN LEU VAL
SEQRES 5 D 121 PRO ILE GLY LYS PRO ALA SER GLU HIS TYR ASP ASP GLU
SEQRES 6 D 121 GLU GLU GLU ASP ASP GLU ASP ASP GLU ASP SER GLU GLU
SEQRES 7 D 121 ASP SER GLU ASP ASP GLU ASP MET GLN ASP MET ASP GLU
SEQRES 8 D 121 MET ASN ASP TYR ASN GLU SER PRO ASP ASP GLY GLU VAL
SEQRES 9 D 121 ASN GLU VAL ASP MET GLU GLY ASN GLU GLN ASP GLN ASP
SEQRES 10 D 121 GLN TRP MET ILE
SEQRES 1 E 110 MET ALA ALA SER SER SER SER SER SER ALA GLY GLY VAL
SEQRES 2 E 110 SER GLY SER SER VAL THR GLY SER GLY PHE SER VAL SER
SEQRES 3 E 110 ASP LEU ALA PRO PRO ARG LYS ALA LEU PHE THR TYR PRO
SEQRES 4 E 110 LYS GLY ALA GLY GLU MET LEU GLU ASP GLY SER GLU ARG
SEQRES 5 E 110 PHE LEU CYS GLU SER VAL PHE SER TYR GLN VAL ALA SER
SEQRES 6 E 110 THR LEU LYS GLN VAL LYS HIS ASP GLN GLN VAL ALA ARG
SEQRES 7 E 110 MET GLU LYS LEU ALA GLY LEU VAL GLU GLU LEU GLU ALA
SEQRES 8 E 110 ASP GLU TRP ARG PHE LYS PRO ILE GLU GLN LEU LEU GLY
SEQRES 9 E 110 PHE THR PRO SER SER GLY
SEQRES 1 F 824 MET THR VAL LEU GLN GLU PRO VAL GLN ALA ALA ILE TRP
SEQRES 2 F 824 GLN ALA LEU ASN HIS TYR ALA TYR ARG ASP ALA VAL PHE
SEQRES 3 F 824 LEU ALA GLU ARG LEU TYR ALA GLU VAL HIS SER GLU GLU
SEQRES 4 F 824 ALA LEU PHE LEU LEU ALA THR CYS TYR TYR ARG SER GLY
SEQRES 5 F 824 LYS ALA TYR LYS ALA TYR ARG LEU LEU LYS GLY HIS SER
SEQRES 6 F 824 CYS THR THR PRO GLN CYS LYS TYR LEU LEU ALA LYS CYS
SEQRES 7 F 824 CYS VAL ASP LEU SER LYS LEU ALA GLU GLY GLU GLN ILE
SEQRES 8 F 824 LEU SER GLY GLY VAL PHE ASN LYS GLN LYS SER HIS ASP
SEQRES 9 F 824 ASP ILE VAL THR GLU PHE GLY ASP SER ALA CYS PHE THR
SEQRES 10 F 824 LEU SER LEU LEU GLY HIS VAL TYR CYS LYS THR ASP ARG
SEQRES 11 F 824 LEU ALA LYS GLY SER GLU CYS TYR GLN LYS SER LEU SER
SEQRES 12 F 824 LEU ASN PRO PHE LEU TRP SER PRO PHE GLU SER LEU CYS
SEQRES 13 F 824 GLU ILE GLY GLU LYS PRO ASP PRO ASP GLN THR PHE LYS
SEQRES 14 F 824 PHE THR SER LEU GLN ASN PHE SER ASN CYS LEU PRO ASN
SEQRES 15 F 824 SER CYS THR THR GLN VAL PRO ASN HIS SER LEU SER HIS
SEQRES 16 F 824 ARG GLN PRO GLU THR VAL LEU THR GLU THR PRO GLN ASP
SEQRES 17 F 824 THR ILE GLU LEU ASN ARG LEU ASN LEU GLU SER SER ASN
SEQRES 18 F 824 SER LYS TYR SER LEU ASN THR ASP SER SER VAL SER TYR
SEQRES 19 F 824 ILE ASP SER ALA VAL ILE SER PRO ASP THR VAL PRO LEU
SEQRES 20 F 824 GLY THR GLY THR SER ILE LEU SER LYS GLN VAL GLN ASN
SEQRES 21 F 824 LYS PRO LYS THR GLY ARG SER LEU LEU GLY GLY PRO ALA
SEQRES 22 F 824 ALA LEU SER PRO LEU THR PRO SER PHE GLY ILE LEU PRO
SEQRES 23 F 824 LEU GLU THR PRO SER PRO GLY ASP GLY SER TYR LEU GLN
SEQRES 24 F 824 ASN TYR THR ASN THR PRO PRO VAL ILE ASP VAL PRO SER
SEQRES 25 F 824 THR GLY ALA PRO SER LYS LYS SER VAL ALA ARG ILE GLY
SEQRES 26 F 824 GLN THR GLY THR LYS SER VAL PHE SER GLN SER GLY ASN
SEQRES 27 F 824 SER ARG GLU VAL THR PRO ILE LEU ALA GLN THR GLN SER
SEQRES 28 F 824 SER GLY PRO GLN THR SER THR THR PRO GLN VAL LEU SER
SEQRES 29 F 824 PRO THR ILE THR SER PRO PRO ASN ALA LEU PRO ARG ARG
SEQRES 30 F 824 SER SER ARG LEU PHE THR SER ASP SER SER THR THR LYS
SEQRES 31 F 824 GLU ASN SER LYS LYS LEU LYS MET LYS PHE PRO PRO GLU
SEQRES 32 F 824 ILE PRO ASN ARG LYS THR LYS SER LYS THR ASN LYS GLY
SEQRES 33 F 824 GLY ILE THR GLN PRO ASN ILE ASN ASP SER LEU GLU ILE
SEQRES 34 F 824 THR LYS LEU ASP SER SER ILE ILE SER GLU GLY LYS ILE
SEQRES 35 F 824 SER THR ILE THR PRO GLN ILE GLN ALA PHE ASN LEU GLN
SEQRES 36 F 824 LYS ALA ALA ALA GLU GLY LEU MET SER LEU LEU ARG GLU
SEQRES 37 F 824 MET GLY LYS GLY TYR LEU SER LEU CYS SER TYR ASN CYS
SEQRES 38 F 824 LYS GLU SER ILE ASN ILE LEU SER HIS LEU PRO SER HIS
SEQRES 39 F 824 HIS TYR ASN THR GLY TRP VAL LEU CYS GLN ILE GLY ARG
SEQRES 40 F 824 ALA TYR PHE GLU LEU SER GLU TYR MET GLN ALA GLU ARG
SEQRES 41 F 824 ILE PHE SER GLU VAL ARG ARG ILE GLU ASN TYR ARG VAL
SEQRES 42 F 824 GLU GLY MET GLU ILE TYR SER THR THR LEU TRP HIS LEU
SEQRES 43 F 824 GLN LYS ASP VAL ALA LEU SER VAL LEU SER LYS ASP LEU
SEQRES 44 F 824 THR ASP MET ASP LYS ASN SER PRO GLU ALA TRP CYS ALA
SEQRES 45 F 824 ALA GLY ASN CYS PHE SER LEU GLN ARG GLU HIS ASP ILE
SEQRES 46 F 824 ALA ILE LYS PHE PHE GLN ARG ALA ILE GLN VAL ASP PRO
SEQRES 47 F 824 ASN TYR ALA TYR ALA TYR THR LEU LEU GLY HIS GLU PHE
SEQRES 48 F 824 VAL LEU THR GLU GLU LEU ASP LYS ALA LEU ALA CYS PHE
SEQRES 49 F 824 ARG ASN ALA ILE ARG VAL ASN PRO ARG HIS TYR ASN ALA
SEQRES 50 F 824 TRP TYR GLY LEU GLY MET ILE TYR TYR LYS GLN GLU LYS
SEQRES 51 F 824 PHE SER LEU ALA GLU MET HIS PHE GLN LYS ALA LEU ASP
SEQRES 52 F 824 ILE ASN PRO GLN SER SER VAL LEU LEU CYS HIS ILE GLY
SEQRES 53 F 824 VAL VAL GLN HIS ALA LEU LYS LYS SER GLU LYS ALA LEU
SEQRES 54 F 824 ASP THR LEU ASN LYS ALA ILE VAL ILE ASP PRO LYS ASN
SEQRES 55 F 824 PRO LEU CYS LYS PHE HIS ARG ALA SER VAL LEU PHE ALA
SEQRES 56 F 824 ASN GLU LYS TYR LYS SER ALA LEU GLN GLU LEU GLU GLU
SEQRES 57 F 824 LEU LYS GLN ILE VAL PRO LYS GLU SER LEU VAL TYR PHE
SEQRES 58 F 824 LEU ILE GLY LYS VAL TYR LYS LYS LEU GLY GLN THR HIS
SEQRES 59 F 824 LEU ALA LEU MET ASN PHE SER TRP ALA MET ASP LEU ASP
SEQRES 60 F 824 PRO LYS GLY ALA ASN ASN GLN ILE LYS GLU ALA ILE ASP
SEQRES 61 F 824 LYS ARG TYR LEU PRO ASP ASP GLU GLU PRO ILE THR GLN
SEQRES 62 F 824 GLU GLU GLN ILE MET GLY THR ASP GLU SER GLN GLU SER
SEQRES 63 F 824 SER MET THR ASP ALA ASP ASP THR GLN LEU HIS ALA ALA
SEQRES 64 F 824 GLU SER ASP GLU PHE
SEQRES 1 G 85 MET LEU ARG ARG LYS PRO THR ARG LEU GLU LEU LYS LEU
SEQRES 2 G 85 GLU ASP ILE GLU GLU PHE GLU ASN ILE ARG LYS ASP LEU
SEQRES 3 G 85 GLU THR ARG LYS LYS GLN LYS GLU ASP VAL GLU VAL VAL
SEQRES 4 G 85 GLY GLY SER ASP GLY GLU GLY ALA ILE GLY LEU SER SER
SEQRES 5 G 85 ASP PRO LYS SER ARG GLU GLN MET ILE ASN ASP ARG ILE
SEQRES 6 G 85 GLY TYR LYS PRO GLN PRO LYS PRO ASN ASN ARG SER SER
SEQRES 7 G 85 GLN PHE GLY SER LEU GLU PHE
SEQRES 1 H 824 MET THR VAL LEU GLN GLU PRO VAL GLN ALA ALA ILE TRP
SEQRES 2 H 824 GLN ALA LEU ASN HIS TYR ALA TYR ARG ASP ALA VAL PHE
SEQRES 3 H 824 LEU ALA GLU ARG LEU TYR ALA GLU VAL HIS SER GLU GLU
SEQRES 4 H 824 ALA LEU PHE LEU LEU ALA THR CYS TYR TYR ARG SER GLY
SEQRES 5 H 824 LYS ALA TYR LYS ALA TYR ARG LEU LEU LYS GLY HIS SER
SEQRES 6 H 824 CYS THR THR PRO GLN CYS LYS TYR LEU LEU ALA LYS CYS
SEQRES 7 H 824 CYS VAL ASP LEU SER LYS LEU ALA GLU GLY GLU GLN ILE
SEQRES 8 H 824 LEU SER GLY GLY VAL PHE ASN LYS GLN LYS SER HIS ASP
SEQRES 9 H 824 ASP ILE VAL THR GLU PHE GLY ASP SER ALA CYS PHE THR
SEQRES 10 H 824 LEU SER LEU LEU GLY HIS VAL TYR CYS LYS THR ASP ARG
SEQRES 11 H 824 LEU ALA LYS GLY SER GLU CYS TYR GLN LYS SER LEU SER
SEQRES 12 H 824 LEU ASN PRO PHE LEU TRP SER PRO PHE GLU SER LEU CYS
SEQRES 13 H 824 GLU ILE GLY GLU LYS PRO ASP PRO ASP GLN THR PHE LYS
SEQRES 14 H 824 PHE THR SER LEU GLN ASN PHE SER ASN CYS LEU PRO ASN
SEQRES 15 H 824 SER CYS THR THR GLN VAL PRO ASN HIS SER LEU SER HIS
SEQRES 16 H 824 ARG GLN PRO GLU THR VAL LEU THR GLU THR PRO GLN ASP
SEQRES 17 H 824 THR ILE GLU LEU ASN ARG LEU ASN LEU GLU SER SER ASN
SEQRES 18 H 824 SER LYS TYR SER LEU ASN THR ASP SER SER VAL SER TYR
SEQRES 19 H 824 ILE ASP SER ALA VAL ILE SER PRO ASP THR VAL PRO LEU
SEQRES 20 H 824 GLY THR GLY THR SER ILE LEU SER LYS GLN VAL GLN ASN
SEQRES 21 H 824 LYS PRO LYS THR GLY ARG SER LEU LEU GLY GLY PRO ALA
SEQRES 22 H 824 ALA LEU SER PRO LEU THR PRO SER PHE GLY ILE LEU PRO
SEQRES 23 H 824 LEU GLU THR PRO SER PRO GLY ASP GLY SER TYR LEU GLN
SEQRES 24 H 824 ASN TYR THR ASN THR PRO PRO VAL ILE ASP VAL PRO SER
SEQRES 25 H 824 THR GLY ALA PRO SER LYS LYS SER VAL ALA ARG ILE GLY
SEQRES 26 H 824 GLN THR GLY THR LYS SER VAL PHE SER GLN SER GLY ASN
SEQRES 27 H 824 SER ARG GLU VAL THR PRO ILE LEU ALA GLN THR GLN SER
SEQRES 28 H 824 SER GLY PRO GLN THR SER THR THR PRO GLN VAL LEU SER
SEQRES 29 H 824 PRO THR ILE THR SER PRO PRO ASN ALA LEU PRO ARG ARG
SEQRES 30 H 824 SER SER ARG LEU PHE THR SER ASP SER SER THR THR LYS
SEQRES 31 H 824 GLU ASN SER LYS LYS LEU LYS MET LYS PHE PRO PRO GLU
SEQRES 32 H 824 ILE PRO ASN ARG LYS THR LYS SER LYS THR ASN LYS GLY
SEQRES 33 H 824 GLY ILE THR GLN PRO ASN ILE ASN ASP SER LEU GLU ILE
SEQRES 34 H 824 THR LYS LEU ASP SER SER ILE ILE SER GLU GLY LYS ILE
SEQRES 35 H 824 SER THR ILE THR PRO GLN ILE GLN ALA PHE ASN LEU GLN
SEQRES 36 H 824 LYS ALA ALA ALA GLU GLY LEU MET SER LEU LEU ARG GLU
SEQRES 37 H 824 MET GLY LYS GLY TYR LEU SER LEU CYS SER TYR ASN CYS
SEQRES 38 H 824 LYS GLU SER ILE ASN ILE LEU SER HIS LEU PRO SER HIS
SEQRES 39 H 824 HIS TYR ASN THR GLY TRP VAL LEU CYS GLN ILE GLY ARG
SEQRES 40 H 824 ALA TYR PHE GLU LEU SER GLU TYR MET GLN ALA GLU ARG
SEQRES 41 H 824 ILE PHE SER GLU VAL ARG ARG ILE GLU ASN TYR ARG VAL
SEQRES 42 H 824 GLU GLY MET GLU ILE TYR SER THR THR LEU TRP HIS LEU
SEQRES 43 H 824 GLN LYS ASP VAL ALA LEU SER VAL LEU SER LYS ASP LEU
SEQRES 44 H 824 THR ASP MET ASP LYS ASN SER PRO GLU ALA TRP CYS ALA
SEQRES 45 H 824 ALA GLY ASN CYS PHE SER LEU GLN ARG GLU HIS ASP ILE
SEQRES 46 H 824 ALA ILE LYS PHE PHE GLN ARG ALA ILE GLN VAL ASP PRO
SEQRES 47 H 824 ASN TYR ALA TYR ALA TYR THR LEU LEU GLY HIS GLU PHE
SEQRES 48 H 824 VAL LEU THR GLU GLU LEU ASP LYS ALA LEU ALA CYS PHE
SEQRES 49 H 824 ARG ASN ALA ILE ARG VAL ASN PRO ARG HIS TYR ASN ALA
SEQRES 50 H 824 TRP TYR GLY LEU GLY MET ILE TYR TYR LYS GLN GLU LYS
SEQRES 51 H 824 PHE SER LEU ALA GLU MET HIS PHE GLN LYS ALA LEU ASP
SEQRES 52 H 824 ILE ASN PRO GLN SER SER VAL LEU LEU CYS HIS ILE GLY
SEQRES 53 H 824 VAL VAL GLN HIS ALA LEU LYS LYS SER GLU LYS ALA LEU
SEQRES 54 H 824 ASP THR LEU ASN LYS ALA ILE VAL ILE ASP PRO LYS ASN
SEQRES 55 H 824 PRO LEU CYS LYS PHE HIS ARG ALA SER VAL LEU PHE ALA
SEQRES 56 H 824 ASN GLU LYS TYR LYS SER ALA LEU GLN GLU LEU GLU GLU
SEQRES 57 H 824 LEU LYS GLN ILE VAL PRO LYS GLU SER LEU VAL TYR PHE
SEQRES 58 H 824 LEU ILE GLY LYS VAL TYR LYS LYS LEU GLY GLN THR HIS
SEQRES 59 H 824 LEU ALA LEU MET ASN PHE SER TRP ALA MET ASP LEU ASP
SEQRES 60 H 824 PRO LYS GLY ALA ASN ASN GLN ILE LYS GLU ALA ILE ASP
SEQRES 61 H 824 LYS ARG TYR LEU PRO ASP ASP GLU GLU PRO ILE THR GLN
SEQRES 62 H 824 GLU GLU GLN ILE MET GLY THR ASP GLU SER GLN GLU SER
SEQRES 63 H 824 SER MET THR ASP ALA ASP ASP THR GLN LEU HIS ALA ALA
SEQRES 64 H 824 GLU SER ASP GLU PHE
SEQRES 1 I 808 MET LEU ARG PHE PRO THR CYS PHE PRO SER PHE ARG VAL
SEQRES 2 I 808 VAL GLY GLU LYS GLN LEU PRO GLN GLU ILE ILE PHE LEU
SEQRES 3 I 808 VAL TRP SER PRO LYS ARG ASP LEU ILE ALA LEU ALA ASN
SEQRES 4 I 808 THR ALA GLY GLU VAL LEU LEU HIS ARG LEU ALA SER PHE
SEQRES 5 I 808 HIS ARG VAL TRP SER PHE PRO PRO ASN GLU ASN THR GLY
SEQRES 6 I 808 LYS GLU VAL THR CYS LEU ALA TRP ARG PRO ASP GLY LYS
SEQRES 7 I 808 LEU LEU ALA PHE ALA LEU ALA ASP THR LYS LYS ILE VAL
SEQRES 8 I 808 LEU CYS ASP VAL GLU LYS PRO GLU SER LEU HIS SER PHE
SEQRES 9 I 808 SER VAL GLU ALA PRO VAL SER CYS MET HIS TRP MET GLU
SEQRES 10 I 808 VAL THR VAL GLU SER SER VAL LEU THR SER PHE TYR ASN
SEQRES 11 I 808 ALA GLU ASP GLU SER ASN LEU LEU LEU PRO LYS LEU PRO
SEQRES 12 I 808 THR LEU PRO LYS ASN TYR SER ASN THR SER LYS ILE PHE
SEQRES 13 I 808 SER GLU GLU ASN SER ASP GLU ILE ILE LYS LEU LEU GLY
SEQRES 14 I 808 ASP VAL ARG LEU ASN ILE LEU VAL LEU GLY GLY SER SER
SEQRES 15 I 808 GLY PHE ILE GLU LEU TYR ALA TYR GLY MET PHE LYS ILE
SEQRES 16 I 808 ALA ARG VAL THR GLY ILE ALA GLY THR CYS LEU ALA LEU
SEQRES 17 I 808 CYS LEU SER SER ASP LEU LYS SER LEU SER VAL VAL THR
SEQRES 18 I 808 GLU VAL SER THR ASN GLY ALA SER GLU VAL SER TYR PHE
SEQRES 19 I 808 GLN LEU GLU THR ASN LEU LEU TYR SER PHE LEU PRO GLU
SEQRES 20 I 808 VAL THR ARG MET ALA ARG LYS PHE THR HIS ILE SER ALA
SEQRES 21 I 808 LEU LEU GLN TYR ILE ASN LEU SER LEU THR CYS MET CYS
SEQRES 22 I 808 GLU ALA TRP GLU GLU ILE LEU MET GLN MET ASP SER ARG
SEQRES 23 I 808 LEU THR LYS PHE VAL GLN GLU LYS ASN THR THR THR SER
SEQRES 24 I 808 VAL GLN ASP GLU PHE MET HIS LEU LEU LEU TRP GLY LYS
SEQRES 25 I 808 ALA SER ALA GLU LEU GLN THR LEU LEU MET ASN GLN LEU
SEQRES 26 I 808 THR VAL LYS GLY LEU LYS LYS LEU GLY GLN SER ILE GLU
SEQRES 27 I 808 SER SER TYR SER SER ILE GLN LYS LEU VAL ILE SER HIS
SEQRES 28 I 808 LEU GLN SER GLY SER GLU SER LEU LEU TYR HIS LEU SER
SEQRES 29 I 808 GLU LEU LYS GLY MET ALA SER TRP LYS GLN LYS TYR GLU
SEQRES 30 I 808 PRO LEU GLY LEU ASP ALA ALA GLY ILE GLU GLU ALA ILE
SEQRES 31 I 808 THR ALA VAL GLY SER PHE ILE LEU LYS ALA ASN GLU LEU
SEQRES 32 I 808 LEU GLN VAL ILE ASP SER SER MET LYS ASN PHE LYS ALA
SEQRES 33 I 808 PHE PHE ARG TRP LEU TYR VAL ALA MET LEU ARG MET THR
SEQRES 34 I 808 ASP ASP HIS VAL LEU PRO GLU LEU ASN LYS MET THR GLN
SEQRES 35 I 808 LYS ASP ILE THR PHE VAL ALA GLU PHE LEU THR GLU HIS
SEQRES 36 I 808 PHE ASN GLU ALA PRO ASP LEU TYR ASN ARG LYS GLY LYS
SEQRES 37 I 808 TYR PHE ASN VAL GLU ARG VAL GLY GLN TYR LEU LYS ASP
SEQRES 38 I 808 GLU ASP ASP ASP LEU VAL SER PRO PRO ASN THR GLU GLY
SEQRES 39 I 808 ASN GLN TRP TYR ASP PHE LEU GLN ASN SER SER HIS LEU
SEQRES 40 I 808 LYS GLU SER PRO LEU LEU PHE PRO TYR TYR PRO ARG LYS
SEQRES 41 I 808 SER LEU HIS PHE VAL LYS ARG ARG MET GLU ASN ILE ILE
SEQRES 42 I 808 ASP GLN CYS LEU GLN LYS PRO ALA ASP VAL ILE GLY LYS
SEQRES 43 I 808 SER MET ASN GLN ALA ILE CYS ILE PRO LEU TYR ARG ASP
SEQRES 44 I 808 THR ARG SER GLU ASP SER THR ARG ARG LEU PHE LYS PHE
SEQRES 45 I 808 PRO PHE LEU TRP ASN ASN LYS THR SER ASN LEU HIS TYR
SEQRES 46 I 808 LEU LEU PHE THR ILE LEU GLU ASP SER LEU TYR LYS MET
SEQRES 47 I 808 CYS ILE LEU ARG ARG HIS THR ASP ILE SER GLN SER VAL
SEQRES 48 I 808 SER ASN GLY LEU ILE ALA ILE LYS PHE GLY SER PHE THR
SEQRES 49 I 808 TYR ALA THR THR GLU LYS VAL ARG ARG SER ILE TYR SER
SEQRES 50 I 808 CYS LEU ASP ALA GLN PHE TYR ASP ASP GLU THR VAL THR
SEQRES 51 I 808 VAL VAL LEU LYS ASP THR VAL GLY ARG GLU GLY ARG ASP
SEQRES 52 I 808 ARG LEU LEU VAL GLN LEU PRO LEU SER LEU VAL TYR ASN
SEQRES 53 I 808 SER GLU ASP SER ALA GLU TYR GLN PHE THR GLY THR TYR
SEQRES 54 I 808 SER THR ARG LEU ASP GLU GLN CYS SER ALA ILE PRO THR
SEQRES 55 I 808 ARG THR MET HIS PHE GLU LYS HIS TRP ARG LEU LEU GLU
SEQRES 56 I 808 SER MET LYS ALA GLN TYR VAL ALA GLY ASN GLY PHE ARG
SEQRES 57 I 808 LYS VAL SER CYS VAL LEU SER SER ASN LEU ARG HIS VAL
SEQRES 58 I 808 ARG VAL PHE GLU MET ASP ILE ASP ASP GLU TRP GLU LEU
SEQRES 59 I 808 ASP GLU SER SER ASP GLU GLU GLU GLU ALA SER ASN LYS
SEQRES 60 I 808 PRO VAL LYS ILE LYS GLU GLU VAL LEU SER GLU SER GLU
SEQRES 61 I 808 ALA GLU ASN GLN GLN ALA GLY ALA ALA ALA LEU ALA PRO
SEQRES 62 I 808 GLU ILE VAL ILE LYS VAL GLU LYS LEU ASP PRO GLU LEU
SEQRES 63 I 808 ASP SER
SEQRES 1 J 620 MET ASN LEU GLU ARG LEU ARG LYS ARG VAL ARG GLN TYR
SEQRES 2 J 620 LEU ASP GLN GLN GLN TYR GLN SER ALA LEU PHE TRP ALA
SEQRES 3 J 620 ASP LYS VAL ALA SER LEU SER ARG GLU GLU PRO GLN ASP
SEQRES 4 J 620 ILE TYR TRP LEU ALA GLN CYS LEU TYR LEU THR ALA GLN
SEQRES 5 J 620 TYR HIS ARG ALA ALA HIS ALA LEU ARG SER ARG LYS LEU
SEQRES 6 J 620 ASP LYS LEU TYR GLU ALA CYS ARG TYR LEU ALA ALA ARG
SEQRES 7 J 620 CYS HIS TYR ALA ALA LYS GLU HIS GLN GLN ALA LEU ASP
SEQRES 8 J 620 VAL LEU ASP MET GLU GLU PRO ILE ASN LYS ARG LEU PHE
SEQRES 9 J 620 GLU LYS TYR LEU LYS ASP GLU SER GLY PHE LYS ASP PRO
SEQRES 10 J 620 SER SER ASP TRP GLU MET SER GLN SER SER ILE LYS SER
SEQRES 11 J 620 SER ILE CYS LEU LEU ARG GLY LYS ILE TYR ASP ALA LEU
SEQRES 12 J 620 ASP ASN ARG THR LEU ALA THR TYR SER TYR LYS GLU ALA
SEQRES 13 J 620 LEU LYS LEU ASP VAL TYR CYS PHE GLU ALA PHE ASP LEU
SEQRES 14 J 620 LEU THR SER HIS HIS MET LEU THR ALA GLN GLU GLU LYS
SEQRES 15 J 620 GLU LEU LEU GLU SER LEU PRO LEU SER LYS LEU CYS ASN
SEQRES 16 J 620 GLU GLU GLN GLU LEU LEU ARG PHE LEU PHE GLU ASN LYS
SEQRES 17 J 620 LEU LYS LYS TYR ASN LYS PRO SER GLU THR VAL ILE PRO
SEQRES 18 J 620 GLU SER VAL ASN GLY LEU GLU LYS ASN LEU ASP VAL VAL
SEQRES 19 J 620 VAL SER LEU ALA GLU ARG HIS TYR TYR ASN CYS ASP PHE
SEQRES 20 J 620 LYS MET CYS TYR LYS LEU THR SER VAL VAL MET GLU LYS
SEQRES 21 J 620 ASP PRO PHE HIS ALA SER CYS LEU PRO VAL HIS ILE GLY
SEQRES 22 J 620 THR LEU VAL GLU LEU ASN LYS ALA ASN GLU LEU PHE TYR
SEQRES 23 J 620 LEU SER HIS LYS LEU VAL ASP LEU TYR PRO SER ASN PRO
SEQRES 24 J 620 VAL SER TRP PHE ALA VAL GLY CYS TYR TYR LEU MET VAL
SEQRES 25 J 620 GLY HIS LYS ASN GLU HIS ALA ARG ARG TYR LEU SER LYS
SEQRES 26 J 620 ALA THR THR LEU GLU LYS THR TYR GLY PRO ALA TRP ILE
SEQRES 27 J 620 ALA TYR GLY HIS SER PHE ALA VAL GLU SER GLU HIS ASP
SEQRES 28 J 620 GLN ALA MET ALA ALA TYR PHE THR ALA ALA GLN LEU MET
SEQRES 29 J 620 LYS GLY CYS HIS LEU PRO MET LEU TYR ILE GLY LEU GLU
SEQRES 30 J 620 TYR GLY LEU THR ASN ASN SER LYS LEU ALA GLU ARG PHE
SEQRES 31 J 620 PHE SER GLN ALA LEU SER ILE ALA PRO GLU ASP PRO PHE
SEQRES 32 J 620 VAL MET HIS GLU VAL GLY VAL VAL ALA PHE GLN ASN GLY
SEQRES 33 J 620 GLU TRP LYS THR ALA GLU LYS TRP PHE LEU ASP ALA LEU
SEQRES 34 J 620 GLU LYS ILE LYS ALA ILE GLY ASN GLU VAL THR VAL ASP
SEQRES 35 J 620 LYS TRP GLU PRO LEU LEU ASN ASN LEU GLY HIS VAL CYS
SEQRES 36 J 620 ARG LYS LEU LYS LYS TYR ALA GLU ALA LEU ASP TYR HIS
SEQRES 37 J 620 ARG GLN ALA LEU VAL LEU ILE PRO GLN ASN ALA SER THR
SEQRES 38 J 620 TYR SER ALA ILE GLY TYR ILE HIS SER LEU MET GLY ASN
SEQRES 39 J 620 PHE GLU ASN ALA VAL ASP TYR PHE HIS THR ALA LEU GLY
SEQRES 40 J 620 LEU ARG ARG ASP ASP THR PHE SER VAL THR MET LEU GLY
SEQRES 41 J 620 HIS CYS ILE GLU MET TYR ILE GLY ASP SER GLU ALA TYR
SEQRES 42 J 620 ILE GLY ALA ASP ILE LYS ASP LYS LEU LYS CYS TYR ASP
SEQRES 43 J 620 PHE ASP VAL HIS THR MET LYS THR LEU LYS ASN ILE ILE
SEQRES 44 J 620 SER PRO PRO TRP ASP PHE ARG GLU PHE GLU VAL GLU LYS
SEQRES 45 J 620 GLN THR ALA GLU GLU THR GLY LEU THR PRO LEU GLU THR
SEQRES 46 J 620 SER ARG LYS THR PRO ASP SER ARG PRO SER LEU GLU GLU
SEQRES 47 J 620 THR PHE GLU ILE GLU MET ASN GLU SER ASP MET MET LEU
SEQRES 48 J 620 GLU THR SER MET SER ASP HIS SER THR
SEQRES 1 K 620 MET ASN LEU GLU ARG LEU ARG LYS ARG VAL ARG GLN TYR
SEQRES 2 K 620 LEU ASP GLN GLN GLN TYR GLN SER ALA LEU PHE TRP ALA
SEQRES 3 K 620 ASP LYS VAL ALA SER LEU SER ARG GLU GLU PRO GLN ASP
SEQRES 4 K 620 ILE TYR TRP LEU ALA GLN CYS LEU TYR LEU THR ALA GLN
SEQRES 5 K 620 TYR HIS ARG ALA ALA HIS ALA LEU ARG SER ARG LYS LEU
SEQRES 6 K 620 ASP LYS LEU TYR GLU ALA CYS ARG TYR LEU ALA ALA ARG
SEQRES 7 K 620 CYS HIS TYR ALA ALA LYS GLU HIS GLN GLN ALA LEU ASP
SEQRES 8 K 620 VAL LEU ASP MET GLU GLU PRO ILE ASN LYS ARG LEU PHE
SEQRES 9 K 620 GLU LYS TYR LEU LYS ASP GLU SER GLY PHE LYS ASP PRO
SEQRES 10 K 620 SER SER ASP TRP GLU MET SER GLN SER SER ILE LYS SER
SEQRES 11 K 620 SER ILE CYS LEU LEU ARG GLY LYS ILE TYR ASP ALA LEU
SEQRES 12 K 620 ASP ASN ARG THR LEU ALA THR TYR SER TYR LYS GLU ALA
SEQRES 13 K 620 LEU LYS LEU ASP VAL TYR CYS PHE GLU ALA PHE ASP LEU
SEQRES 14 K 620 LEU THR SER HIS HIS MET LEU THR ALA GLN GLU GLU LYS
SEQRES 15 K 620 GLU LEU LEU GLU SER LEU PRO LEU SER LYS LEU CYS ASN
SEQRES 16 K 620 GLU GLU GLN GLU LEU LEU ARG PHE LEU PHE GLU ASN LYS
SEQRES 17 K 620 LEU LYS LYS TYR ASN LYS PRO SER GLU THR VAL ILE PRO
SEQRES 18 K 620 GLU SER VAL ASP GLY LEU GLU LYS ASN LEU ASP VAL VAL
SEQRES 19 K 620 VAL SER LEU ALA GLU ARG HIS TYR TYR ASN CYS ASP PHE
SEQRES 20 K 620 LYS MET CYS TYR LYS LEU THR SER VAL VAL MET GLU LYS
SEQRES 21 K 620 ASP PRO PHE HIS LYS SER CYS LEU PRO VAL HIS ILE GLY
SEQRES 22 K 620 THR LEU VAL GLU LEU ASN LYS ALA ASN GLU LEU PHE TYR
SEQRES 23 K 620 LEU SER HIS LYS LEU VAL ASP LEU TYR PRO SER ASN PRO
SEQRES 24 K 620 VAL SER TRP PHE ALA VAL GLY CYS TYR TYR LEU MET VAL
SEQRES 25 K 620 GLY HIS LYS ASN GLU HIS ALA ARG ARG TYR LEU SER LYS
SEQRES 26 K 620 ALA THR THR LEU GLU LYS THR TYR GLY PRO ALA TRP ILE
SEQRES 27 K 620 ALA TYR GLY HIS SER PHE ALA VAL GLU SER GLU HIS ASP
SEQRES 28 K 620 GLN ALA MET ALA ALA TYR PHE THR ALA ALA GLN LEU MET
SEQRES 29 K 620 LYS GLY CYS HIS LEU PRO MET LEU TYR ILE GLY LEU GLU
SEQRES 30 K 620 TYR GLY LEU THR ASN ASN SER LYS LEU ALA GLU ARG PHE
SEQRES 31 K 620 PHE SER GLN ALA LEU SER ILE ALA PRO GLU ASP PRO PHE
SEQRES 32 K 620 VAL MET HIS GLU VAL GLY VAL VAL ALA PHE GLN ASN GLY
SEQRES 33 K 620 GLU TRP LYS THR ALA GLU LYS TRP PHE LEU ASP ALA LEU
SEQRES 34 K 620 GLU LYS ILE LYS ALA ILE GLY ASN GLU VAL THR VAL ASP
SEQRES 35 K 620 LYS TRP GLU PRO LEU LEU ASN ASN LEU GLY HIS VAL CYS
SEQRES 36 K 620 ARG LYS LEU LYS LYS TYR ALA GLU ALA LEU ASP TYR HIS
SEQRES 37 K 620 ARG GLN ALA LEU VAL LEU ILE PRO GLN ASN ALA SER THR
SEQRES 38 K 620 TYR SER ALA ILE GLY TYR ILE HIS SER LEU MET GLY ASN
SEQRES 39 K 620 PHE GLU ASN ALA VAL ASP TYR PHE HIS THR ALA LEU GLY
SEQRES 40 K 620 LEU ARG ARG ASP ASP THR PHE SER VAL THR MET LEU GLY
SEQRES 41 K 620 HIS CYS ILE GLU MET TYR ILE GLY ASP SER GLU ALA TYR
SEQRES 42 K 620 ILE GLY ALA ASP ILE LYS ASP LYS LEU LYS CYS TYR ASP
SEQRES 43 K 620 PHE ASP VAL HIS THR MET LYS THR LEU LYS ASN ILE ILE
SEQRES 44 K 620 SER PRO PRO TRP ASP PHE ARG GLU PHE GLU VAL GLU LYS
SEQRES 45 K 620 GLN THR ALA GLU GLU THR GLY LEU THR PRO LEU GLU THR
SEQRES 46 K 620 SER ARG LYS THR PRO ASP SER ARG PRO SER LEU GLU GLU
SEQRES 47 K 620 THR PHE GLU ILE GLU MET ASN GLU SER ASP MET MET LEU
SEQRES 48 K 620 GLU THR SER MET SER ASP HIS SER THR
SEQRES 1 L 183 THR THR PRO ASN LYS THR PRO PRO GLY ALA ASP PRO LYS
SEQRES 2 L 183 GLN LEU GLU ARG THR GLY THR VAL ARG GLU ILE GLY SER
SEQRES 3 L 183 GLN ALA VAL TRP SER LEU SER SER CYS LYS PRO GLY PHE
SEQRES 4 L 183 GLY VAL ASP GLN LEU ARG ASP ASP ASN LEU GLU THR TYR
SEQRES 5 L 183 TRP GLN SER ASP GLY SER GLN PRO HIS LEU VAL ASN ILE
SEQRES 6 L 183 GLN PHE ARG ARG LYS THR THR VAL LYS THR LEU CYS ILE
SEQRES 7 L 183 TYR ALA ASP TYR LYS SER ASP GLU SER TYR THR PRO SER
SEQRES 8 L 183 LYS ILE SER VAL ARG VAL GLY ASN ASN PHE HIS ASN LEU
SEQRES 9 L 183 GLN GLU ILE ARG GLN LEU GLU LEU VAL GLU PRO SER GLY
SEQRES 10 L 183 TRP ILE HIS VAL PRO LEU THR ASP ASN HIS LYS LYS PRO
SEQRES 11 L 183 THR ARG THR PHE MET ILE GLN ILE ALA VAL LEU ALA ASN
SEQRES 12 L 183 HIS GLN ASN GLY ARG ASP THR HIS MET ARG GLN ILE LYS
SEQRES 13 L 183 ILE TYR THR PRO VAL GLU SER SER ILE GLY LYS PHE PRO
SEQRES 14 L 183 ARG CYS THR THR ILE ASP PHE MET MET TYR ARG SER ILE
SEQRES 15 L 183 ARG
SEQRES 1 M 74 MET ASP SER GLU VAL GLN ARG ASP GLY ARG ILE LEU ASP
SEQRES 2 M 74 LEU ILE ASP ASP ALA TRP ARG GLU ASP LYS LEU PRO TYR
SEQRES 3 M 74 GLU ASP VAL ALA ILE PRO LEU ASN GLU LEU PRO GLU PRO
SEQRES 4 M 74 GLU GLN ASP ASN GLY GLY THR THR GLU SER VAL LYS GLU
SEQRES 5 M 74 GLN GLU MET LYS TRP THR ASP LEU ALA LEU GLN TYR LEU
SEQRES 6 M 74 HIS GLU ASN VAL PRO PRO ILE GLY ASN
SEQRES 1 N 822 MET ALA ALA ALA VAL VAL VAL ALA GLU GLY ASP SER ASP
SEQRES 2 N 822 SER ARG PRO GLY GLN GLU LEU LEU VAL ALA TRP ASN THR
SEQRES 3 N 822 VAL SER THR GLY LEU VAL PRO PRO ALA ALA LEU GLY LEU
SEQRES 4 N 822 VAL SER SER ARG THR SER GLY ALA VAL PRO PRO LYS GLU
SEQRES 5 N 822 GLU GLU LEU ARG ALA ALA VAL GLU VAL LEU ARG GLY HIS
SEQRES 6 N 822 GLY LEU HIS SER VAL LEU GLU GLU TRP PHE VAL GLU VAL
SEQRES 7 N 822 LEU GLN ASN ASP LEU GLN ALA ASN ILE SER PRO GLU PHE
SEQRES 8 N 822 TRP ASN ALA ILE SER GLN CYS GLU ASN SER ALA ASP GLU
SEQRES 9 N 822 PRO GLN CYS LEU LEU LEU LEU LEU ASP ALA PHE GLY LEU
SEQRES 10 N 822 LEU GLU SER ARG LEU ASP PRO TYR LEU ARG SER LEU GLU
SEQRES 11 N 822 LEU LEU GLU LYS TRP THR ARG LEU GLY LEU LEU MET GLY
SEQRES 12 N 822 THR GLY ALA GLN GLY LEU ARG GLU GLU VAL HIS THR MET
SEQRES 13 N 822 LEU ARG GLY VAL LEU PHE PHE SER THR PRO ARG THR PHE
SEQRES 14 N 822 GLN GLU MET ILE GLN ARG LEU TYR GLY CYS PHE LEU ARG
SEQRES 15 N 822 VAL TYR MET GLN SER LYS ARG LYS GLY GLU GLY GLY THR
SEQRES 16 N 822 ASP PRO GLU LEU GLU GLY GLU LEU ASP SER ARG TYR ALA
SEQRES 17 N 822 ARG ARG ARG TYR TYR ARG LEU LEU GLN SER PRO LEU CYS
SEQRES 18 N 822 ALA GLY CYS SER SER ASP LYS GLN GLN CYS TRP CYS ARG
SEQRES 19 N 822 GLN ALA LEU GLU GLN PHE HIS GLN LEU SER GLN VAL LEU
SEQRES 20 N 822 HIS ARG LEU SER LEU LEU GLU ARG VAL SER ALA GLU ALA
SEQRES 21 N 822 VAL THR THR THR LEU HIS GLN VAL THR ARG GLU ARG MET
SEQRES 22 N 822 GLU ASP ARG CYS ARG GLY GLU TYR GLU ARG SER PHE LEU
SEQRES 23 N 822 ARG GLU PHE HIS LYS TRP ILE GLU ARG VAL VAL GLY TRP
SEQRES 24 N 822 LEU GLY LYS VAL PHE LEU GLN ASP GLY PRO ALA ARG PRO
SEQRES 25 N 822 ALA SER PRO GLU ALA GLY ASN THR LEU ARG ARG TRP ARG
SEQRES 26 N 822 CYS HIS VAL GLN ARG PHE PHE TYR ARG ILE TYR ALA SER
SEQRES 27 N 822 LEU ARG ILE GLU GLU LEU PHE SER ILE VAL ARG ASP PHE
SEQRES 28 N 822 PRO ASP SER ARG PRO ALA ILE GLU ASP LEU LYS TYR CYS
SEQRES 29 N 822 LEU GLU ARG THR ASP GLN ARG GLN GLN LEU LEU VAL SER
SEQRES 30 N 822 LEU LYS ALA ALA LEU GLU THR ARG LEU LEU HIS PRO GLY
SEQRES 31 N 822 VAL ASN THR CYS ASP ILE ILE THR LEU TYR ILE SER ALA
SEQRES 32 N 822 ILE LYS ALA LEU ARG VAL ILE ASP PRO SER MET VAL ILE
SEQRES 33 N 822 LEU GLU VAL ALA CYS GLU PRO ILE ARG ARG TYR LEU ARG
SEQRES 34 N 822 THR ARG GLU ASP THR VAL ARG GLN ILE VAL ALA GLY LEU
SEQRES 35 N 822 THR GLY ASP SER ASP GLY THR GLY ASP LEU ALA VAL GLU
SEQRES 36 N 822 LEU SER LYS THR ASP PRO ALA SER LEU GLU THR GLY GLN
SEQRES 37 N 822 ASP SER GLU ASP ASP SER GLY GLU PRO GLU ASP TRP VAL
SEQRES 38 N 822 PRO ASP PRO VAL ASP ALA ASP PRO GLY LYS SER SER SER
SEQRES 39 N 822 LYS ARG ARG SER SER ASP ILE ILE SER LEU LEU VAL SER
SEQRES 40 N 822 ILE TYR GLY SER LYS ASP LEU PHE ILE ASN GLU TYR ARG
SEQRES 41 N 822 SER LEU LEU ALA ASP ARG LEU LEU HIS GLN PHE SER PHE
SEQRES 42 N 822 SER PRO GLU ARG GLU ILE ARG ASN VAL GLU LEU LEU LYS
SEQRES 43 N 822 LEU ARG PHE GLY GLU ALA PRO MET HIS PHE CYS GLU VAL
SEQRES 44 N 822 MET LEU LYS ASP MET ALA ASP SER ARG ARG ILE ASN ALA
SEQRES 45 N 822 ASN ILE ARG GLU GLU ASP GLU LYS ARG PRO ALA GLU GLU
SEQRES 46 N 822 GLN PRO PRO PHE GLY VAL TYR ALA VAL ILE LEU SER SER
SEQRES 47 N 822 GLU PHE TRP PRO PRO PHE LYS ASP GLU LYS LEU GLU VAL
SEQRES 48 N 822 PRO GLU ASP ILE ARG ALA ALA LEU GLU ALA TYR CYS LYS
SEQRES 49 N 822 LYS TYR GLU GLN LEU LYS ALA MET ARG THR LEU SER TRP
SEQRES 50 N 822 LYS HIS THR LEU GLY LEU VAL THR MET ASP VAL GLU LEU
SEQRES 51 N 822 ALA ASP ARG THR LEU SER VAL ALA VAL THR PRO VAL GLN
SEQRES 52 N 822 ALA VAL ILE LEU LEU TYR PHE GLN ASP GLN ALA SER TRP
SEQRES 53 N 822 THR LEU GLU GLU LEU SER LYS ALA VAL LYS MET PRO VAL
SEQRES 54 N 822 ALA LEU LEU ARG ARG ARG MET SER VAL TRP LEU GLN GLN
SEQRES 55 N 822 GLY VAL LEU ARG GLU GLU PRO PRO GLY THR PHE SER VAL
SEQRES 56 N 822 ILE GLU GLU GLU ARG PRO GLN ASP ARG ASP ASN MET VAL
SEQRES 57 N 822 LEU ILE ASP SER ASP ASP GLU SER ASP SER GLY MET ALA
SEQRES 58 N 822 SER GLN ALA ASP GLN LYS GLU GLU GLU LEU LEU LEU PHE
SEQRES 59 N 822 TRP THR TYR ILE GLN ALA MET LEU THR ASN LEU GLU SER
SEQRES 60 N 822 LEU SER LEU ASP ARG ILE TYR ASN MET LEU ARG MET PHE
SEQRES 61 N 822 VAL VAL THR GLY PRO ALA LEU ALA GLU ILE ASP LEU GLN
SEQRES 62 N 822 GLU LEU GLN GLY TYR LEU GLN LYS LYS VAL ARG ASP GLN
SEQRES 63 N 822 GLN LEU VAL TYR SER ALA GLY VAL TYR ARG LEU PRO LYS
SEQRES 64 N 822 ASN CYS SER
SEQRES 1 O 756 MET ALA SER VAL HIS GLU SER LEU TYR PHE ASN PRO MET
SEQRES 2 O 756 MET THR ASN GLY VAL VAL HIS ALA ASN VAL PHE GLY ILE
SEQRES 3 O 756 LYS ASP TRP VAL THR PRO TYR LYS ILE ALA VAL LEU VAL
SEQRES 4 O 756 LEU LEU SER GLU MET SER ARG THR GLY GLU GLY ALA VAL
SEQRES 5 O 756 SER LEU VAL GLU ARG ARG ARG LEU ASN GLN GLN LEU LEU
SEQRES 6 O 756 PRO LEU LEU GLN GLY PRO ASP ILE THR VAL SER LYS LEU
SEQRES 7 O 756 LEU LYS LEU ILE GLU GLU SER CYS PRO GLN LEU ALA ASN
SEQRES 8 O 756 SER VAL GLN ILE ARG ILE LYS LEU MET ALA GLU GLY GLU
SEQRES 9 O 756 LEU LYS ASP MET GLU GLN PHE PHE ASP ASP LEU SER ASP
SEQRES 10 O 756 SER PHE SER GLY THR GLU PRO GLU VAL HIS LYS THR SER
SEQRES 11 O 756 VAL VAL GLY LEU PHE LEU ARG HIS MET ILE LEU ALA TYR
SEQRES 12 O 756 SER LYS LEU SER PHE SER GLN VAL PHE LYS LEU TYR THR
SEQRES 13 O 756 ALA LEU GLN GLN TYR PHE GLN SER ASP GLU ASN LYS LYS
SEQRES 14 O 756 THR VAL GLU ASP ALA ASP MET GLU LEU THR SER ARG ASP
SEQRES 15 O 756 GLU GLY GLU ARG LYS MET GLU LYS GLU GLU LEU ASP VAL
SEQRES 16 O 756 SER VAL ARG GLU GLU GLU VAL SER CYS SER GLY PRO LEU
SEQRES 17 O 756 SER GLN LYS GLN ALA GLU PHE PHE LEU SER GLN GLN ALA
SEQRES 18 O 756 SER LEU LEU LYS ASN ASP GLU THR LYS ALA LEU THR PRO
SEQRES 19 O 756 ALA SER LEU GLN LYS GLU LEU ASN ASN LEU LEU LYS PHE
SEQRES 20 O 756 ASN PRO ASP PHE ALA GLU ALA HIS TYR LEU SER TYR LEU
SEQRES 21 O 756 ASN ASN LEU ARG VAL GLN ASP VAL PHE SER SER THR HIS
SEQRES 22 O 756 SER LEU LEU HIS TYR PHE ASP ARG LEU ILE LEU THR GLY
SEQRES 23 O 756 ALA GLU SER LYS SER ASN GLY GLU GLU GLY TYR GLY ARG
SEQRES 24 O 756 SER LEU ARG TYR ALA ALA LEU ASN LEU ALA ALA LEU HIS
SEQRES 25 O 756 CYS ARG PHE GLY HIS TYR GLN GLN ALA GLU LEU ALA LEU
SEQRES 26 O 756 GLN GLU ALA ILE ARG ILE ALA GLN GLU SER ASN ASP HIS
SEQRES 27 O 756 VAL CYS LEU GLN HIS CYS LEU SER TRP LEU TYR VAL LEU
SEQRES 28 O 756 GLY GLN LYS ARG SER ASP SER TYR VAL LEU LEU GLU HIS
SEQRES 29 O 756 SER VAL LYS LYS ALA VAL HIS PHE GLY LEU PRO TYR LEU
SEQRES 30 O 756 ALA SER LEU GLY ILE GLN SER LEU VAL GLN GLN ARG ALA
SEQRES 31 O 756 PHE ALA GLY LYS THR ALA ASN LYS LEU MET ASP ALA LEU
SEQRES 32 O 756 LYS ASP SER ASP LEU LEU HIS TRP LYS HIS SER LEU SER
SEQRES 33 O 756 GLU LEU ILE ASP ILE SER ILE ALA GLN LYS THR ALA ILE
SEQRES 34 O 756 TRP ARG LEU TYR GLY ARG SER THR MET ALA LEU GLN GLN
SEQRES 35 O 756 ALA GLN MET LEU LEU SER MET ASN SER LEU GLU ALA VAL
SEQRES 36 O 756 ASN ALA GLY VAL GLN GLN ASN ASN THR GLU SER PHE ALA
SEQRES 37 O 756 VAL ALA LEU CYS HIS LEU ALA GLU LEU HIS ALA GLU GLN
SEQRES 38 O 756 GLY CYS PHE ALA ALA ALA SER GLU VAL LEU LYS HIS LEU
SEQRES 39 O 756 LYS GLU ARG PHE PRO PRO ASN SER GLN HIS ALA GLN LEU
SEQRES 40 O 756 TRP MET LEU CYS ASP GLN LYS ILE GLN PHE ASP ARG ALA
SEQRES 41 O 756 MET ASN ASP GLY LYS TYR HIS LEU ALA ASP SER LEU VAL
SEQRES 42 O 756 THR GLY ILE THR ALA LEU ASN SER ILE GLU GLY VAL TYR
SEQRES 43 O 756 ARG LYS ALA VAL VAL LEU GLN ALA GLN ASN GLN MET SER
SEQRES 44 O 756 GLU ALA HIS LYS LEU LEU GLN LYS LEU LEU VAL HIS CYS
SEQRES 45 O 756 GLN LYS LEU LYS ASN THR GLU MET VAL ILE SER VAL LEU
SEQRES 46 O 756 LEU SER VAL ALA GLU LEU TYR TRP ARG SER SER SER PRO
SEQRES 47 O 756 THR ILE ALA LEU PRO MET LEU LEU GLN ALA LEU ALA LEU
SEQRES 48 O 756 SER LYS GLU TYR ARG LEU GLN TYR LEU ALA SER GLU THR
SEQRES 49 O 756 VAL LEU ASN LEU ALA PHE ALA GLN LEU ILE LEU GLY ILE
SEQRES 50 O 756 PRO GLU GLN ALA LEU SER LEU LEU HIS MET ALA ILE GLU
SEQRES 51 O 756 PRO ILE LEU ALA ASP GLY ALA ILE LEU ASP LYS GLY ARG
SEQRES 52 O 756 ALA MET PHE LEU VAL ALA LYS CYS GLN VAL ALA SER ALA
SEQRES 53 O 756 ALA SER TYR ASP GLN PRO LYS LYS ALA GLU ALA LEU GLU
SEQRES 54 O 756 ALA ALA ILE GLU ASN LEU ASN GLU ALA LYS ASN TYR PHE
SEQRES 55 O 756 ALA LYS VAL ASP CYS LYS GLU ARG ILE ARG ASP VAL VAL
SEQRES 56 O 756 TYR PHE GLN ALA ARG LEU TYR HIS THR LEU GLY LYS THR
SEQRES 57 O 756 GLN GLU ARG ASN ARG CYS ALA MET LEU PHE ARG GLN LEU
SEQRES 58 O 756 HIS GLN GLU LEU PRO SER HIS GLY VAL PRO LEU ILE ASN
SEQRES 59 O 756 HIS LEU
SEQRES 1 P 591 MET VAL PRO VAL ALA VAL THR ALA ALA VAL ALA PRO VAL
SEQRES 2 P 591 LEU SER ILE ASN SER ASP PHE SER ASP LEU ARG GLU ILE
SEQRES 3 P 591 LYS LYS GLN LEU LEU LEU ILE ALA GLY LEU THR ARG GLU
SEQRES 4 P 591 ARG GLY LEU LEU HIS SER SER LYS TRP SER ALA GLU LEU
SEQRES 5 P 591 ALA PHE SER LEU PRO ALA LEU PRO LEU ALA GLU LEU GLN
SEQRES 6 P 591 PRO PRO PRO PRO ILE THR GLU GLU ASP ALA GLN ASP MET
SEQRES 7 P 591 ASP ALA TYR THR LEU ALA LYS ALA TYR PHE ASP VAL LYS
SEQRES 8 P 591 GLU TYR ASP ARG ALA ALA HIS PHE LEU HIS GLY CYS ASN
SEQRES 9 P 591 SER LYS LYS ALA TYR PHE LEU TYR MET TYR SER ARG TYR
SEQRES 10 P 591 LEU SER GLY GLU LYS LYS LYS ASP ASP GLU THR VAL ASP
SEQRES 11 P 591 SER LEU GLY PRO LEU GLU LYS GLY GLN VAL LYS ASN GLU
SEQRES 12 P 591 ALA LEU ARG GLU LEU ARG VAL GLU LEU SER LYS LEU HIS
SEQRES 13 P 591 GLN ALA ARG GLU LEU ASP GLY PHE GLY LEU TYR LEU TYR
SEQRES 14 P 591 GLY VAL VAL LEU ARG LYS LEU ASP LEU VAL LYS GLU ALA
SEQRES 15 P 591 ILE ASP VAL PHE VAL GLU ALA THR HIS VAL LEU PRO LEU
SEQRES 16 P 591 HIS TRP GLY ALA TRP LEU GLU LEU CYS ASN LEU ILE THR
SEQRES 17 P 591 ASP LYS GLU MET LEU LYS PHE LEU SER LEU PRO ASP THR
SEQRES 18 P 591 TRP MET LYS GLU PHE PHE LEU ALA HIS ILE TYR THR GLU
SEQRES 19 P 591 LEU GLN LEU ILE GLU GLU ALA LEU GLN LYS TYR GLN ASN
SEQRES 20 P 591 LEU ILE ASP VAL GLY PHE SER LYS SER SER TYR ILE VAL
SEQRES 21 P 591 SER GLN ILE ALA VAL ALA TYR HIS ASN ILE ARG ASP ILE
SEQRES 22 P 591 ASP LYS ALA LEU SER ILE PHE ASN GLU LEU ARG LYS GLN
SEQRES 23 P 591 ASP PRO TYR ARG ILE GLU ASN MET ASP THR PHE SER ASN
SEQRES 24 P 591 LEU LEU TYR VAL ARG SER MET LYS SER GLU LEU SER TYR
SEQRES 25 P 591 LEU ALA HIS ASN LEU CYS GLU ILE ASP LYS TYR ARG VAL
SEQRES 26 P 591 GLU THR CYS CYS VAL ILE GLY ASN TYR TYR SER LEU ARG
SEQRES 27 P 591 SER GLN HIS GLU LYS ALA ALA LEU TYR PHE GLN ARG ALA
SEQRES 28 P 591 LEU LYS LEU ASN PRO ARG TYR LEU GLY ALA TRP THR LEU
SEQRES 29 P 591 MET GLY HIS GLU TYR MET GLU MET LYS ASN THR SER ALA
SEQRES 30 P 591 ALA ILE GLN ALA TYR ARG HIS ALA ILE GLU VAL ASN LYS
SEQRES 31 P 591 ARG ASP TYR ARG ALA TRP TYR GLY LEU GLY GLN THR TYR
SEQRES 32 P 591 GLU ILE LEU LYS MET PRO PHE TYR CYS LEU TYR TYR TYR
SEQRES 33 P 591 ARG ARG ALA HIS GLN LEU ARG PRO ASN ASP SER ARG MET
SEQRES 34 P 591 LEU VAL ALA LEU GLY GLU CYS TYR GLU LYS LEU ASN GLN
SEQRES 35 P 591 LEU VAL GLU ALA LYS LYS CYS TYR TRP ARG ALA TYR ALA
SEQRES 36 P 591 VAL GLY ASP VAL GLU LYS MET ALA LEU VAL LYS LEU ALA
SEQRES 37 P 591 LYS LEU HIS GLU GLN LEU THR GLU SER GLU GLN ALA ALA
SEQRES 38 P 591 GLN CYS TYR ILE LYS TYR ILE GLN ASP ILE TYR SER CYS
SEQRES 39 P 591 GLY GLU ILE VAL GLU HIS LEU GLU GLU SER THR ALA PHE
SEQRES 40 P 591 ARG TYR LEU ALA GLN TYR TYR PHE LYS CYS LYS LEU TRP
SEQRES 41 P 591 ASP GLU ALA SER THR CYS ALA GLN LYS CYS CYS ALA PHE
SEQRES 42 P 591 ASN ASP THR ARG GLU GLU GLY LYS ALA LEU LEU ARG GLN
SEQRES 43 P 591 ILE LEU GLN LEU ARG ASN GLN GLY GLU THR PRO THR THR
SEQRES 44 P 591 GLU VAL PRO ALA PRO PHE PHE LEU PRO ALA SER LEU SER
SEQRES 45 P 591 ALA ASN ASN THR PRO THR ARG ARG VAL SER PRO LEU ASN
SEQRES 46 P 591 LEU SER SER VAL THR PRO
SEQRES 1 R 493 MET ASP GLN ASP TYR GLU ARG ARG LEU LEU ARG GLN ILE
SEQRES 2 R 493 VAL ILE GLN ASN GLU ASN THR MET PRO ARG VAL THR GLU
SEQRES 3 R 493 MET ARG ARG THR LEU THR PRO ALA SER SER PRO VAL SER
SEQRES 4 R 493 SER PRO SER LYS HIS GLY ASP ARG PHE ILE PRO SER ARG
SEQRES 5 R 493 ALA GLY ALA ASN TRP SER VAL ASN PHE HIS ARG ILE ASN
SEQRES 6 R 493 GLU ASN GLU LYS SER PRO SER GLN ASN ARG LYS ALA LYS
SEQRES 7 R 493 ASP ALA THR SER ASP ASN GLY LYS ASP GLY LEU ALA TYR
SEQRES 8 R 493 SER ALA LEU LEU LYS ASN GLU LEU LEU GLY ALA GLY ILE
SEQRES 9 R 493 GLU LYS VAL GLN ASP PRO GLN THR GLU ASP ARG ARG LEU
SEQRES 10 R 493 GLN PRO SER THR PRO GLU LYS LYS GLY LEU PHE THR TYR
SEQRES 11 R 493 SER LEU SER THR LYS ARG SER SER PRO ASP ASP GLY ASN
SEQRES 12 R 493 ASP VAL SER PRO TYR SER LEU SER PRO VAL SER ASN LYS
SEQRES 13 R 493 SER GLN LYS LEU LEU ARG SER PRO ARG LYS PRO THR ARG
SEQRES 14 R 493 LYS ILE SER LYS ILE PRO PHE LYS VAL LEU ASP ALA PRO
SEQRES 15 R 493 GLU LEU GLN ASP ASP PHE TYR LEU ASN LEU VAL ASP TRP
SEQRES 16 R 493 SER SER LEU ASN VAL LEU SER VAL GLY LEU GLY THR CYS
SEQRES 17 R 493 VAL TYR LEU TRP SER ALA CYS THR SER GLN VAL THR ARG
SEQRES 18 R 493 LEU CYS ASP LEU SER VAL GLU GLY ASP SER VAL THR SER
SEQRES 19 R 493 VAL GLY TRP SER GLU ARG GLY ASN LEU VAL ALA VAL GLY
SEQRES 20 R 493 THR HIS LYS GLY PHE VAL GLN ILE TRP ASP ALA ALA ALA
SEQRES 21 R 493 GLY LYS LYS LEU SER MET LEU GLU GLY HIS THR ALA ARG
SEQRES 22 R 493 VAL GLY ALA LEU ALA TRP ASN ALA GLU GLN LEU SER SER
SEQRES 23 R 493 GLY SER ARG ASP ARG MET ILE LEU GLN ARG ASP ILE ARG
SEQRES 24 R 493 THR PRO PRO LEU GLN SER GLU ARG ARG LEU GLN GLY HIS
SEQRES 25 R 493 ARG GLN GLU VAL CYS GLY LEU LYS TRP SER THR ASP HIS
SEQRES 26 R 493 GLN LEU LEU ALA SER GLY GLY ASN ASP ASN LYS LEU LEU
SEQRES 27 R 493 VAL TRP ASN HIS SER SER LEU SER PRO VAL GLN GLN TYR
SEQRES 28 R 493 THR GLU HIS LEU ALA ALA VAL LYS ALA ILE ALA TRP SER
SEQRES 29 R 493 PRO HIS GLN HIS GLY LEU LEU ALA SER GLY GLY GLY THR
SEQRES 30 R 493 ALA ASP ARG CYS ILE ARG PHE TRP ASN THR LEU THR GLY
SEQRES 31 R 493 GLN PRO LEU GLN CYS ILE ASP THR GLY SER GLN VAL CYS
SEQRES 32 R 493 ASN LEU ALA TRP SER LYS HIS ALA ASN GLU LEU VAL SER
SEQRES 33 R 493 THR HIS GLY TYR SER GLN ASN GLN ILE LEU VAL TRP LYS
SEQRES 34 R 493 TYR PRO SER LEU THR GLN VAL ALA LYS LEU THR GLY HIS
SEQRES 35 R 493 SER TYR ARG VAL LEU TYR LEU ALA MET SER PRO ASP GLY
SEQRES 36 R 493 GLU ALA ILE VAL THR GLY ALA GLY ASP GLU THR LEU ARG
SEQRES 37 R 493 PHE TRP ASN VAL PHE SER LYS THR ARG SER THR LYS GLU
SEQRES 38 R 493 SER VAL SER VAL LEU ASN LEU PHE THR ARG ILE ARG
SEQRES 1 S 447 MET SER ARG ARG PRO CYS SER CYS ALA LEU ARG PRO PRO
SEQRES 2 S 447 ARG CYS SER CYS SER ALA SER PRO SER ALA VAL THR ALA
SEQRES 3 S 447 ALA GLY ARG PRO ARG PRO SER ASP SER CYS LYS GLU GLU
SEQRES 4 S 447 SER SER THR LEU SER VAL LYS MET LYS CYS ASP PHE ASN
SEQRES 5 S 447 CYS ASN HIS VAL HIS SER GLY LEU LYS LEU VAL LYS PRO
SEQRES 6 S 447 ASP ASP ILE GLY ARG LEU VAL SER TYR THR PRO ALA TYR
SEQRES 7 S 447 LEU GLU GLY SER CYS LYS ASP CYS ILE LYS ASP TYR GLU
SEQRES 8 S 447 ARG LEU SER CYS ILE GLY SER PRO ILE VAL SER PRO ARG
SEQRES 9 S 447 ILE VAL GLN LEU GLU THR GLU SER LYS ARG LEU HIS ASN
SEQRES 10 S 447 LYS GLU ASN GLN HIS VAL GLN GLN THR LEU ASN SER THR
SEQRES 11 S 447 ASN GLU ILE GLU ALA LEU GLU THR SER ARG LEU TYR GLU
SEQRES 12 S 447 ASP SER GLY TYR SER SER PHE SER LEU GLN SER GLY LEU
SEQRES 13 S 447 SER GLU HIS GLU GLU GLY SER LEU LEU GLU GLU ASN PHE
SEQRES 14 S 447 GLY ASP SER LEU GLN SER CYS LEU LEU GLN ILE GLN SER
SEQRES 15 S 447 PRO ASP GLN TYR PRO ASN LYS ASN LEU LEU PRO VAL LEU
SEQRES 16 S 447 HIS PHE GLU LYS VAL VAL CYS SER THR LEU LYS LYS ASN
SEQRES 17 S 447 ALA LYS ARG ASN PRO LYS VAL ASP ARG GLU MET LEU LYS
SEQRES 18 S 447 GLU ILE ILE ALA ARG GLY ASN PHE ARG LEU GLN ASN ILE
SEQRES 19 S 447 ILE GLY ARG LYS MET GLY LEU GLU CYS VAL ASP ILE LEU
SEQRES 20 S 447 SER GLU LEU PHE ARG ARG GLY LEU ARG HIS VAL LEU ALA
SEQRES 21 S 447 THR ILE LEU ALA GLN LEU SER ASP MET ASP LEU ILE ASN
SEQRES 22 S 447 VAL SER LYS VAL SER THR THR TRP LYS LYS ILE LEU GLU
SEQRES 23 S 447 ASP ASP LYS GLY ALA PHE GLN LEU TYR SER LYS ALA ILE
SEQRES 24 S 447 GLN ARG VAL THR GLU ASN ASN ASN LYS PHE SER PRO HIS
SEQRES 25 S 447 ALA SER THR ARG GLU TYR VAL MET PHE ARG ILE PRO LEU
SEQRES 26 S 447 LYS SER VAL GLN LYS SER ALA ALA GLN THR SER LEU LYS
SEQRES 27 S 447 LYS ASP ALA GLN THR LYS LEU SER ASN GLN GLY ASP GLN
SEQRES 28 S 447 LYS GLY SER THR TYR SER ARG HIS ASN GLU PHE SER GLU
SEQRES 29 S 447 VAL ALA LYS THR LEU LYS LYS ASN GLU SER LEU LYS ALA
SEQRES 30 S 447 CYS ILE ARG CYS ASN SER PRO ALA LYS TYR ASP CYS TYR
SEQRES 31 S 447 LEU GLN ARG ALA THR CYS LYS ARG GLU GLY CYS GLY PHE
SEQRES 32 S 447 ASP TYR CYS THR LYS CYS LEU CYS ASN TYR HIS THR THR
SEQRES 33 S 447 LYS ASP CYS SER ASP GLY LYS LEU LEU LYS ALA SER CYS
SEQRES 34 S 447 LYS ILE GLY PRO LEU PRO GLY THR LYS LYS SER LYS LYS
SEQRES 35 S 447 ASN LEU ARG ARG LEU
SEQRES 1 T 21 ALA ALA ALA ALA ALA GLN LEU ALA ALA ALA ALA ALA ALA
SEQRES 2 T 21 ALA ALA ALA ALA ALA ALA ALA ALA
SEQRES 1 U 24 MET SER ARG ARG PRO CYS SER CYS ALA LEU ARG PRO PRO
SEQRES 2 U 24 ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA ALA
SEQRES 1 W 85 MET LEU ARG ARG LYS PRO THR ARG LEU GLU LEU LYS LEU
SEQRES 2 W 85 ASP ASP ILE GLU GLU PHE GLU ASN ILE ARG LYS ASP LEU
SEQRES 3 W 85 GLU THR ARG LYS LYS GLN LYS GLU ASP VAL GLU VAL VAL
SEQRES 4 W 85 GLY GLY SER ASP GLY GLU GLY ALA ILE GLY LEU SER SER
SEQRES 5 W 85 ASP PRO LYS SER ARG GLU GLN MET ILE ASN ASP ARG ILE
SEQRES 6 W 85 GLY TYR LYS PRO GLN PRO LYS PRO ASN ASN ARG SER SER
SEQRES 7 W 85 GLN PHE GLY SER LEU GLU PHE
SEQRES 1 X 565 MET ASN VAL ILE ASP HIS VAL ARG ASP MET ALA ALA ALA
SEQRES 2 X 565 GLY LEU HIS SER ASN VAL ARG LEU LEU SER SER LEU LEU
SEQRES 3 X 565 LEU THR LEU SER ASN ASN ASN PRO GLU LEU PHE SER PRO
SEQRES 4 X 565 PRO GLN LYS TYR GLN LEU LEU VAL TYR HIS ALA ASP SER
SEQRES 5 X 565 LEU PHE HIS ASP LYS GLU TYR ARG ASN ALA VAL SER LYS
SEQRES 6 X 565 TYR THR MET ALA LEU GLN GLN LYS LYS ALA LEU SER LYS
SEQRES 7 X 565 THR SER LYS VAL ARG PRO SER THR GLY ASN SER ALA SER
SEQRES 8 X 565 THR PRO GLN SER GLN CYS LEU PRO SER GLU ILE GLU VAL
SEQRES 9 X 565 LYS TYR LYS LEU ALA GLU CYS TYR THR VAL LEU LYS GLN
SEQRES 10 X 565 ASP LYS ASP ALA ILE ALA ILE LEU ASP GLY ILE PRO SER
SEQRES 11 X 565 ARG GLN ARG THR PRO LYS ILE ASN MET MET LEU ALA ASN
SEQRES 12 X 565 LEU TYR LYS LYS ALA GLY GLN GLU ARG PRO SER VAL THR
SEQRES 13 X 565 SER TYR LYS GLU VAL LEU ARG GLN CYS PRO LEU ALA LEU
SEQRES 14 X 565 ASP ALA ILE LEU GLY LEU LEU SER LEU SER VAL LYS GLY
SEQRES 15 X 565 ALA GLU VAL ALA SER MET THR MET ASN VAL ILE GLN THR
SEQRES 16 X 565 VAL PRO ASN LEU ASP TRP LEU SER VAL TRP ILE LYS ALA
SEQRES 17 X 565 TYR ALA PHE VAL HIS THR GLY ASP ASN SER ARG ALA ILE
SEQRES 18 X 565 SER THR ILE CYS SER LEU GLU LYS LYS SER LEU LEU ARG
SEQRES 19 X 565 ASP ASN VAL ASP LEU LEU GLY SER LEU ALA ASP LEU TYR
SEQRES 20 X 565 PHE ARG ALA GLY ASP ASN LYS ASN SER VAL LEU LYS PHE
SEQRES 21 X 565 GLU GLN ALA GLN MET LEU ASP PRO TYR LEU ILE LYS GLY
SEQRES 22 X 565 MET ASP VAL TYR GLY TYR LEU LEU ALA ARG GLU GLY ARG
SEQRES 23 X 565 LEU GLU ASP VAL GLU ASN LEU GLY CYS ARG LEU PHE ASN
SEQRES 24 X 565 ILE SER ASP GLN HIS ALA GLU PRO TRP VAL VAL SER GLY
SEQRES 25 X 565 CYS HIS SER PHE TYR SER LYS ARG TYR SER ARG ALA LEU
SEQRES 26 X 565 TYR LEU GLY ALA LYS ALA ILE GLN LEU ASN SER ASN SER
SEQRES 27 X 565 VAL GLN ALA LEU LEU LEU LYS GLY ALA ALA LEU ARG ASN
SEQRES 28 X 565 MET GLY ARG VAL GLN GLU ALA ILE ILE HIS PHE ARG GLU
SEQRES 29 X 565 ALA ILE ARG LEU ALA PRO CYS ARG LEU ASP CYS TYR GLU
SEQRES 30 X 565 GLY LEU ILE GLU CYS TYR LEU ALA SER ASN SER ILE ARG
SEQRES 31 X 565 GLU ALA MET VAL MET ALA ASN ASN VAL TYR LYS THR LEU
SEQRES 32 X 565 GLY ALA ASN ALA GLN THR LEU THR LEU LEU ALA THR VAL
SEQRES 33 X 565 CYS LEU GLU ASP PRO VAL THR GLN GLU LYS ALA LYS THR
SEQRES 34 X 565 LEU LEU ASN LYS ALA LEU THR GLN GLU PRO ASP TYR ILE
SEQRES 35 X 565 LYS ALA VAL VAL LYS LYS ALA GLU LEU LEU SER ARG GLU
SEQRES 36 X 565 GLN LYS TYR GLU ASP GLY ILE ALA LEU LEU ARG ASN ALA
SEQRES 37 X 565 LEU ALA ASN GLN SER ASP CYS VAL LEU HIS ARG ILE LEU
SEQRES 38 X 565 GLY ASP PHE LEU VAL ALA VAL ASN GLU TYR GLN GLU ALA
SEQRES 39 X 565 MET ASP GLN TYR SER ILE ALA LEU SER LEU ASP PRO ASN
SEQRES 40 X 565 ASP GLN LYS SER LEU GLU GLY MET GLN LYS MET GLU LYS
SEQRES 41 X 565 GLU GLU SER PRO THR ASP ALA THR GLN GLU GLU ASP VAL
SEQRES 42 X 565 ASP ASP MET GLU GLY SER GLY GLU GLU GLY ASP LEU GLU
SEQRES 43 X 565 GLY SER ASP SER GLU ALA ALA GLN TRP ALA ASP GLN GLU
SEQRES 44 X 565 GLN TRP PHE GLY MET GLN
SEQRES 1 Y 565 MET ASN VAL ILE ASP HIS VAL ARG ASP MET ALA ALA ALA
SEQRES 2 Y 565 GLY LEU HIS SER ASN VAL ARG LEU LEU SER SER LEU LEU
SEQRES 3 Y 565 LEU THR LEU SER ASN ASN ASN PRO GLU LEU PHE SER PRO
SEQRES 4 Y 565 PRO GLN LYS TYR GLN LEU LEU VAL TYR HIS ALA ASP SER
SEQRES 5 Y 565 LEU PHE HIS ASP LYS GLU TYR ARG ASN ALA VAL SER LYS
SEQRES 6 Y 565 TYR THR MET ALA LEU GLN GLN LYS LYS ALA LEU SER LYS
SEQRES 7 Y 565 THR SER LYS VAL ARG PRO SER THR GLY ASN SER ALA SER
SEQRES 8 Y 565 THR PRO GLN SER GLN CYS LEU PRO SER GLU ILE GLU VAL
SEQRES 9 Y 565 LYS TYR LYS LEU ALA GLU CYS TYR THR VAL LEU LYS GLN
SEQRES 10 Y 565 ASP LYS ASP ALA ILE ALA ILE LEU ASP GLY ILE PRO SER
SEQRES 11 Y 565 ARG GLN ARG THR PRO LYS ILE ASN MET MET LEU ALA ASN
SEQRES 12 Y 565 LEU TYR LYS LYS ALA GLY GLN GLU ARG PRO SER VAL THR
SEQRES 13 Y 565 SER TYR LYS GLU VAL LEU ARG GLN CYS PRO LEU ALA LEU
SEQRES 14 Y 565 ASP ALA ILE LEU GLY LEU LEU SER LEU SER VAL LYS GLY
SEQRES 15 Y 565 ALA GLU VAL ALA SER MET THR MET ASN VAL ILE GLN THR
SEQRES 16 Y 565 VAL PRO ASN LEU ASP TRP LEU SER VAL TRP ILE LYS ALA
SEQRES 17 Y 565 TYR ALA PHE VAL HIS THR GLY ASP ASN SER ARG ALA ILE
SEQRES 18 Y 565 SER THR ILE CYS SER LEU GLU LYS LYS SER LEU LEU ARG
SEQRES 19 Y 565 ASP ASN VAL ASP LEU LEU GLY SER LEU ALA ASP LEU TYR
SEQRES 20 Y 565 PHE ARG ALA GLY ASP ASN LYS ASN SER VAL LEU LYS PHE
SEQRES 21 Y 565 GLU GLN ALA GLN MET LEU ASP PRO TYR LEU ILE LYS GLY
SEQRES 22 Y 565 MET ASP VAL TYR GLY TYR LEU LEU ALA ARG GLU GLY ARG
SEQRES 23 Y 565 LEU GLU ASP VAL GLU ASN LEU GLY CYS ARG LEU PHE ASN
SEQRES 24 Y 565 ILE SER ASP GLN HIS ALA GLU PRO TRP VAL VAL SER GLY
SEQRES 25 Y 565 CYS HIS SER PHE TYR SER LYS ARG TYR SER ARG ALA LEU
SEQRES 26 Y 565 TYR LEU GLY ALA LYS ALA ILE GLN LEU ASN SER ASN SER
SEQRES 27 Y 565 VAL GLN ALA LEU LEU LEU LYS GLY ALA ALA LEU ARG ASN
SEQRES 28 Y 565 MET GLY ARG VAL GLN GLU ALA ILE ILE HIS PHE ARG GLU
SEQRES 29 Y 565 ALA ILE ARG LEU ALA PRO CYS ARG LEU ASP CYS TYR GLU
SEQRES 30 Y 565 GLY LEU ILE GLU CYS TYR LEU ALA SER ASN SER ILE ARG
SEQRES 31 Y 565 GLU ALA MET VAL MET ALA ASN ASN VAL TYR LYS THR LEU
SEQRES 32 Y 565 GLY ALA ASN ALA GLN THR LEU THR LEU LEU ALA THR VAL
SEQRES 33 Y 565 CYS LEU GLU ASP PRO VAL THR GLN GLU LYS ALA LYS THR
SEQRES 34 Y 565 LEU LEU ASN LYS ALA LEU THR GLN GLU PRO ASP TYR ILE
SEQRES 35 Y 565 LYS ALA VAL VAL LYS LYS ALA GLU LEU LEU SER ARG GLU
SEQRES 36 Y 565 GLN LYS TYR GLU ASP GLY ILE ALA LEU LEU ARG ASN ALA
SEQRES 37 Y 565 LEU ALA ASN GLN SER ASP CYS VAL LEU HIS ARG ILE LEU
SEQRES 38 Y 565 GLY ASP PHE LEU VAL ALA VAL ASN GLU TYR GLN GLU ALA
SEQRES 39 Y 565 MET ASP GLN TYR SER ILE ALA LEU SER LEU ASP PRO ASN
SEQRES 40 Y 565 ASP GLN LYS SER LEU GLU GLY MET GLN LYS MET GLU LYS
SEQRES 41 Y 565 GLU GLU SER PRO THR ASP ALA THR GLN GLU GLU ASP VAL
SEQRES 42 Y 565 ASP ASP MET GLU GLY SER GLY GLU GLU GLY ASP LEU GLU
SEQRES 43 Y 565 GLY SER ASP SER GLU ALA ALA GLN TRP ALA ASP GLN GLU
SEQRES 44 Y 565 GLN TRP PHE GLY MET GLN
HET ZN B 101 1
HET ZN B 102 1
HET ZN B 103 1
HET ZN S 601 1
HET ZN S 602 1
HETNAM ZN ZINC ION
FORMUL 24 ZN 5(ZN 2+)
HELIX 1 1 PRO A 22 HIS A 31 1 10
HELIX 2 2 LYS A 284 ASN A 294 1 11
HELIX 3 3 SER A 615 LEU A 629 1 15
HELIX 4 4 LYS A 631 ALA A 647 1 17
HELIX 5 5 SER A 655 MET A 667 1 13
HELIX 6 6 HIS A 758 THR A 777 1 20
HELIX 7 7 GLU A 781 LYS A 798 1 18
HELIX 8 8 GLY A 800 TYR A 810 1 11
HELIX 9 9 SER A 843 GLY A 854 1 12
HELIX 10 10 CYS A 867 LEU A 882 1 16
HELIX 11 11 SER A 924 VAL A 937 1 14
HELIX 12 12 ARG A 942 THR A 946 5 5
HELIX 13 13 PRO A 948 GLN A 965 1 18
HELIX 14 14 PRO A 971 ILE A 978 1 8
HELIX 15 15 ARG A 980 SER A 984 5 5
HELIX 16 16 ASN A 1020 TRP A 1028 1 9
HELIX 17 17 LEU A 1032 LEU A 1041 1 10
HELIX 18 18 SER A 1058 THR A 1088 1 31
HELIX 19 19 THR A 1132 LYS A 1146 1 15
HELIX 20 20 ASP A 1154 ASN A 1161 1 8
HELIX 21 21 LEU A 1168 GLY A 1183 1 16
HELIX 22 22 HIS A 1184 LEU A 1188 5 5
HELIX 23 23 ALA A 1189 GLY A 1200 1 12
HELIX 24 24 HIS A 1201 LEU A 1217 1 17
HELIX 25 25 ASP A 1221 ILE A 1232 1 12
HELIX 26 26 PRO A 1246 TYR A 1261 1 16
HELIX 27 27 HIS A 1266 GLY A 1278 1 13
HELIX 28 28 ASP A 1290 LEU A 1307 1 18
HELIX 29 29 ASN A 1320 GLY A 1331 1 12
HELIX 30 30 ASN A 1359 TYR A 1375 1 17
HELIX 31 31 ASN A 1380 LEU A 1387 1 8
HELIX 32 32 THR A 1392 VAL A 1399 1 8
HELIX 33 33 LYS A 1400 LEU A 1415 1 16
HELIX 34 34 ASN A 1422 VAL A 1430 1 9
HELIX 35 35 PRO A 1431 ASN A 1437 1 7
HELIX 36 36 ASN A 1453 PHE A 1476 1 24
HELIX 37 37 ASN A 1481 SER A 1500 1 20
HELIX 38 38 ASN A 1503 GLY A 1508 1 6
HELIX 39 39 GLY A 1508 MET A 1527 1 20
HELIX 40 40 ASN A 1532 THR A 1546 1 15
HELIX 41 41 ASN A 1551 PHE A 1566 1 16
HELIX 42 42 ASN A 1578 LEU A 1588 1 11
HELIX 43 43 LEU A 1603 HIS A 1608 5 6
HELIX 44 44 LEU A 1609 ALA A 1613 1 5
HELIX 45 45 THR A 1684 LYS A 1693 1 10
HELIX 46 46 ASP A 1747 CYS A 1758 1 12
HELIX 47 47 LYS A 1767 GLN A 1784 1 18
HELIX 48 48 GLU A 1788 ARG A 1806 1 19
HELIX 49 49 THR A 1811 SER A 1825 1 15
HELIX 50 50 PHE A 1847 GLY A 1866 1 20
HELIX 51 51 GLY A 1867 SER A 1876 1 10
HELIX 52 52 LEU A 1881 SER A 1896 1 16
HELIX 53 53 SER A 1911 PHE A 1921 1 11
HELIX 54 54 LYS A 1925 ALA A 1935 1 11
HELIX 55 55 MET B 57 GLN B 68 1 12
HELIX 56 56 ASP C 28 GLY C 47 1 20
HELIX 57 57 LEU C 48 LEU C 62 1 15
HELIX 58 58 THR C 77 LYS C 97 1 21
HELIX 59 59 GLU C 98 HIS C 107 1 10
HELIX 60 60 SER C 111 SER C 137 1 27
HELIX 61 61 ALA C 150 ARG C 165 1 16
HELIX 62 62 GLY C 169 LEU C 182 1 14
HELIX 63 63 LEU C 184 LEU C 199 1 16
HELIX 64 64 HIS C 202 ILE C 213 1 12
HELIX 65 65 ASP C 215 LEU C 222 1 8
HELIX 66 66 TRP C 228 GLN C 242 1 15
HELIX 67 67 LEU C 243 VAL C 257 1 15
HELIX 68 68 SER C 262 ARG C 277 1 16
HELIX 69 69 ASP C 278 ASP C 293 1 16
HELIX 70 70 ASN C 299 ARG C 310 1 12
HELIX 71 71 MET C 312 ASP C 327 1 16
HELIX 72 72 ARG C 330 SER C 345 1 16
HELIX 73 73 GLN C 346 ASN C 361 1 16
HELIX 74 74 LEU C 365 MET C 378 1 14
HELIX 75 75 ASN C 380 ASN C 395 1 16
HELIX 76 76 ASP C 398 LEU C 412 1 15
HELIX 77 77 MET C 414 ARG C 429 1 16
HELIX 78 78 ASP C 432 ASN C 447 1 16
HELIX 79 79 GLN C 448 GLY C 463 1 16
HELIX 80 80 MET C 468 LEU C 480 1 13
HELIX 81 81 SER C 483 CYS C 500 1 18
HELIX 82 82 GLU C 509 CYS C 523 1 15
HELIX 83 83 LEU C 525 ASN C 540 1 16
HELIX 84 84 ARG C 543 ARG C 557 1 15
HELIX 85 85 VAL D 25 GLU D 46 1 22
HELIX 86 86 ARG E 52 ASP E 92 1 41
HELIX 87 87 PRO E 98 LEU E 103 1 6
HELIX 88 88 GLU F 6 HIS F 18 1 13
HELIX 89 89 ALA F 20 HIS F 36 1 17
HELIX 90 90 SER F 37 SER F 51 1 15
HELIX 91 91 LYS F 53 HIS F 64 1 12
HELIX 92 92 THR F 68 LEU F 82 1 15
HELIX 93 93 LYS F 84 GLY F 94 1 11
HELIX 94 94 HIS F 103 GLY F 111 1 9
HELIX 95 95 SER F 113 ASP F 129 1 17
HELIX 96 96 ARG F 130 ASN F 145 1 16
HELIX 97 97 LEU F 148 ILE F 158 1 11
HELIX 98 98 ALA F 451 TYR F 479 1 29
HELIX 99 99 ASN F 480 HIS F 490 1 11
HELIX 100 100 THR F 498 LEU F 512 1 15
HELIX 101 101 GLU F 514 GLU F 529 1 16
HELIX 102 102 GLY F 535 GLN F 547 1 13
HELIX 103 103 LYS F 548 ASP F 563 1 16
HELIX 104 104 SER F 566 GLN F 580 1 15
HELIX 105 105 GLU F 582 ASP F 597 1 16
HELIX 106 106 TYR F 600 GLU F 615 1 16
HELIX 107 107 GLU F 616 ASN F 631 1 16
HELIX 108 108 HIS F 634 GLN F 648 1 15
HELIX 109 109 LYS F 650 ASN F 665 1 16
HELIX 110 110 SER F 668 LYS F 683 1 16
HELIX 111 111 LYS F 684 ASP F 699 1 16
HELIX 112 112 ASN F 702 ASN F 716 1 15
HELIX 113 113 LYS F 718 VAL F 733 1 16
HELIX 114 114 GLU F 736 GLY F 751 1 16
HELIX 115 115 GLN F 752 ASP F 767 1 16
HELIX 116 116 LYS F 769 ARG F 819 1 14
HELIX 117 117 LYS G 12 ASP G 25 1 14
HELIX 118 118 GLU H 6 HIS H 18 1 13
HELIX 119 119 ALA H 20 HIS H 36 1 17
HELIX 120 120 SER H 37 SER H 51 1 15
HELIX 121 121 LYS H 53 HIS H 64 1 12
HELIX 122 122 THR H 68 LEU H 82 1 15
HELIX 123 123 LYS H 84 GLY H 94 1 11
HELIX 124 124 HIS H 103 GLY H 111 1 9
HELIX 125 125 SER H 113 ASP H 129 1 17
HELIX 126 126 ARG H 130 ASN H 145 1 16
HELIX 127 127 LEU H 148 ILE H 158 1 11
HELIX 128 128 ASP H 163 LYS H 169 1 7
HELIX 129 129 ALA H 451 TYR H 479 1 29
HELIX 130 130 ASN H 480 HIS H 490 1 11
HELIX 131 131 THR H 498 LEU H 512 1 15
HELIX 132 132 GLU H 514 GLU H 529 1 16
HELIX 133 133 GLY H 535 GLN H 547 1 13
HELIX 134 134 LYS H 548 ASP H 563 1 16
HELIX 135 135 SER H 566 GLN H 580 1 15
HELIX 136 136 GLU H 582 ASP H 597 1 16
HELIX 137 137 TYR H 600 GLU H 615 1 16
HELIX 138 138 GLU H 616 ASN H 631 1 16
HELIX 139 139 HIS H 634 GLN H 648 1 15
HELIX 140 140 LYS H 650 ASN H 665 1 16
HELIX 141 141 SER H 668 LYS H 683 1 16
HELIX 142 142 LYS H 684 ASP H 699 1 16
HELIX 143 143 ASN H 702 ASN H 716 1 15
HELIX 144 144 LYS H 718 VAL H 733 1 16
HELIX 145 145 GLU H 736 GLY H 751 1 16
HELIX 146 146 GLN H 752 ASP H 771 1 16
HELIX 147 147 LEU I 49 PHE I 52 5 4
HELIX 148 148 GLU I 132 LEU I 137 1 6
HELIX 149 149 GLU I 163 ASP I 170 1 8
HELIX 150 150 TYR I 190 MET I 192 5 3
HELIX 151 151 THR I 238 PHE I 244 1 7
HELIX 152 152 PHE I 244 LYS I 294 1 51
HELIX 153 153 SER I 299 TRP I 310 1 12
HELIX 154 154 ALA I 315 LEU I 325 1 11
HELIX 155 155 THR I 326 HIS I 351 1 26
HELIX 156 156 HIS I 351 TRP I 372 1 22
HELIX 157 157 TRP I 372 GLU I 377 1 6
HELIX 158 158 ASP I 382 THR I 429 1 48
HELIX 159 159 THR I 441 PHE I 456 1 16
HELIX 160 160 ARG I 474 ASP I 481 1 8
HELIX 161 161 ASN I 495 ASN I 503 1 9
HELIX 162 162 SER I 505 SER I 510 1 6
HELIX 163 163 SER I 521 MET I 548 1 28
HELIX 164 164 SER I 672 VAL I 674 5 3
HELIX 165 165 ASP I 679 TYR I 683 5 5
HELIX 166 166 ASN J 2 GLN J 17 1 16
HELIX 167 167 GLN J 18 ARG J 34 1 17
HELIX 168 168 GLU J 36 THR J 50 1 15
HELIX 169 169 GLN J 52 ARG J 63 1 12
HELIX 170 170 LYS J 64 GLU J 70 1 7
HELIX 171 171 GLU J 70 LYS J 84 1 15
HELIX 172 172 GLN J 87 ASP J 94 1 8
HELIX 173 173 SER J 124 ASP J 144 1 21
HELIX 174 174 ASN J 145 VAL J 161 1 17
HELIX 175 175 CYS J 163 HIS J 173 1 11
HELIX 176 176 THR J 177 LEU J 188 1 12
HELIX 177 177 CYS J 194 LEU J 209 1 16
HELIX 178 178 ASN J 230 CYS J 245 1 16
HELIX 179 179 ASP J 246 ASP J 261 1 16
HELIX 180 180 SER J 266 LEU J 278 1 13
HELIX 181 181 LYS J 280 TYR J 295 1 16
HELIX 182 182 ASN J 298 GLY J 313 1 16
HELIX 183 183 LYS J 315 GLU J 330 1 16
HELIX 184 184 TYR J 333 SER J 348 1 16
HELIX 185 185 GLU J 349 MET J 364 1 16
HELIX 186 186 HIS J 368 THR J 381 1 14
HELIX 187 187 ASN J 383 ILE J 397 1 15
HELIX 188 188 ASP J 401 GLY J 416 1 16
HELIX 189 189 TRP J 418 ALA J 434 1 17
HELIX 190 190 TRP J 444 LEU J 458 1 15
HELIX 191 191 LYS J 460 ILE J 475 1 16
HELIX 192 192 ASN J 478 MET J 492 1 15
HELIX 193 193 ASN J 494 ARG J 509 1 16
HELIX 194 194 ASP J 512 ASP J 529 1 18
HELIX 195 195 ASN K 2 GLN K 17 1 16
HELIX 196 196 GLN K 18 ARG K 34 1 17
HELIX 197 197 GLU K 36 THR K 50 1 15
HELIX 198 198 GLN K 52 SER K 62 1 11
HELIX 199 199 LYS K 64 TYR K 69 1 6
HELIX 200 200 TYR K 69 ALA K 83 1 15
HELIX 201 201 GLN K 87 LEU K 93 1 7
HELIX 202 202 ILE K 128 ASP K 144 1 17
HELIX 203 203 ASN K 145 VAL K 161 1 17
HELIX 204 204 CYS K 163 SER K 172 1 10
HELIX 205 205 HIS K 173 MET K 175 5 3
HELIX 206 206 ALA K 178 LEU K 188 1 11
HELIX 207 207 CYS K 194 LYS K 211 1 18
HELIX 208 208 THR K 218 ASP K 225 1 8
HELIX 209 209 GLY K 226 LYS K 229 5 4
HELIX 210 210 ASN K 230 CYS K 245 1 16
HELIX 211 211 ASP K 246 ASP K 261 1 16
HELIX 212 212 SER K 266 LEU K 278 1 13
HELIX 213 213 LYS K 280 TYR K 295 1 16
HELIX 214 214 ASN K 298 GLY K 313 1 16
HELIX 215 215 LYS K 315 GLU K 330 1 16
HELIX 216 216 GLY K 334 SER K 348 1 15
HELIX 217 217 GLU K 349 MET K 364 1 16
HELIX 218 218 HIS K 368 THR K 381 1 14
HELIX 219 219 ASN K 383 ALA K 398 1 16
HELIX 220 220 ASP K 401 GLY K 416 1 16
HELIX 221 221 GLU K 417 ILE K 435 1 19
HELIX 222 222 THR K 440 LEU K 458 1 19
HELIX 223 223 LYS K 460 ILE K 475 1 16
HELIX 224 224 ASN K 478 MET K 492 1 15
HELIX 225 225 ASN K 494 ARG K 509 1 16
HELIX 226 226 ASP K 512 ILE K 527 1 16
HELIX 227 227 ASP L 12 GLY L 20 1 9
HELIX 228 228 GLY L 41 ARG L 46 1 6
HELIX 229 229 HIS L 145 GLY L 148 5 4
HELIX 230 230 THR L 174 SER L 182 1 9
HELIX 231 231 ASP M 8 ASP M 16 1 9
HELIX 232 232 SER M 49 LYS M 56 1 8
HELIX 233 233 ARG N 15 THR N 29 1 15
HELIX 234 234 GLU N 53 ARG N 63 1 11
HELIX 235 235 LEU N 79 TRP N 92 1 14
HELIX 236 236 ASN N 93 GLU N 99 1 7
HELIX 237 237 CYS N 107 ASP N 123 1 17
HELIX 238 238 ASP N 123 GLY N 139 1 17
HELIX 239 239 LEU N 149 PHE N 162 1 14
HELIX 240 240 PRO N 166 GLY N 191 1 26
HELIX 241 241 LEU N 203 LEU N 215 1 13
HELIX 242 242 ARG N 234 LEU N 250 1 17
HELIX 243 243 LEU N 252 ARG N 278 1 27
HELIX 244 244 ARG N 287 PHE N 304 1 18
HELIX 245 245 TRP N 324 ARG N 349 1 26
HELIX 246 246 SER N 354 ARG N 367 1 14
HELIX 247 247 GLN N 370 LEU N 386 1 17
HELIX 248 248 ASP N 395 VAL N 409 1 15
HELIX 249 249 MET N 414 CYS N 421 1 8
HELIX 250 250 CYS N 421 GLU N 432 1 12
HELIX 251 251 ASP N 433 LEU N 442 1 10
HELIX 252 252 ASP N 451 LYS N 458 1 8
HELIX 253 253 SER N 499 GLY N 510 1 12
HELIX 254 254 LYS N 512 GLN N 530 1 19
HELIX 255 255 GLU N 536 PHE N 549 1 14
HELIX 256 256 MET N 554 ASP N 563 1 10
HELIX 257 257 MET N 564 LYS N 580 1 17
HELIX 258 258 ARG N 581 GLU N 584 5 4
HELIX 259 259 PRO N 612 LEU N 629 1 18
HELIX 260 260 LYS N 638 GLY N 642 5 5
HELIX 261 261 THR N 660 ASP N 672 1 13
HELIX 262 262 THR N 677 LYS N 686 1 10
HELIX 263 263 PRO N 688 GLY N 703 1 16
HELIX 264 264 THR O 31 SER O 45 1 15
HELIX 265 265 SER O 53 GLY O 70 1 18
HELIX 266 266 THR O 74 CYS O 86 1 13
HELIX 267 267 GLN O 88 GLY O 103 1 16
HELIX 268 268 GLU O 104 GLY O 121 1 18
HELIX 269 269 THR O 129 LEU O 146 1 18
HELIX 270 270 SER O 147 LYS O 169 1 23
HELIX 271 271 SER O 208 ASP O 226 1 19
HELIX 272 272 THR O 232 ASN O 247 1 16
HELIX 273 273 ALA O 251 GLN O 265 1 15
HELIX 274 274 ASP O 266 LEU O 281 1 16
HELIX 275 275 GLY O 297 PHE O 314 1 18
HELIX 276 276 HIS O 316 ASN O 335 1 20
HELIX 277 277 ASP O 336 GLY O 351 1 16
HELIX 278 278 SER O 357 HIS O 370 1 14
HELIX 279 279 LEU O 373 GLY O 392 1 20
HELIX 280 280 THR O 394 SER O 413 1 20
HELIX 281 281 LEU O 414 TYR O 432 1 19
HELIX 282 282 ARG O 434 MET O 448 1 15
HELIX 283 283 ASN O 462 GLN O 480 1 19
HELIX 284 284 CYS O 482 PHE O 497 1 16
HELIX 285 285 HIS O 503 GLY O 523 1 21
HELIX 286 286 LYS O 524 SER O 540 1 17
HELIX 287 287 SER O 540 ASN O 555 1 16
HELIX 288 288 GLN O 556 LYS O 575 1 20
HELIX 289 289 ASN O 576 SER O 594 1 19
HELIX 290 290 SER O 596 THR O 598 5 3
HELIX 291 291 ILE O 599 TYR O 614 1 16
HELIX 292 292 LEU O 616 LEU O 634 1 19
HELIX 293 293 ILE O 636 ASP O 654 1 19
HELIX 294 294 ILE O 657 TYR O 678 1 22
HELIX 295 295 LYS O 682 ASP O 705 1 24
HELIX 296 296 LYS O 707 GLY O 725 1 19
HELIX 297 297 LYS O 726 HIS O 741 1 16
HELIX 298 298 ASP P 28 GLY P 47 1 20
HELIX 299 299 LEU P 48 LEU P 62 1 15
HELIX 300 300 THR P 77 LYS P 97 1 21
HELIX 301 301 GLU P 98 HIS P 107 1 10
HELIX 302 302 SER P 111 THR P 134 1 24
HELIX 303 303 ASN P 148 ARG P 165 1 18
HELIX 304 304 GLY P 169 LEU P 182 1 14
HELIX 305 305 LEU P 184 LEU P 199 1 16
HELIX 306 306 HIS P 202 ILE P 213 1 12
HELIX 307 307 ASP P 215 LEU P 222 1 8
HELIX 308 308 TRP P 228 LEU P 241 1 14
HELIX 309 309 LEU P 243 VAL P 257 1 15
HELIX 310 310 SER P 262 ILE P 276 1 15
HELIX 311 311 ASP P 278 ASP P 293 1 16
HELIX 312 312 ASN P 299 ARG P 310 1 12
HELIX 313 313 MET P 312 ASP P 327 1 16
HELIX 314 314 ARG P 330 SER P 345 1 16
HELIX 315 315 GLN P 346 ASN P 361 1 16
HELIX 316 316 TYR P 364 MET P 378 1 15
HELIX 317 317 ASN P 380 ASN P 395 1 16
HELIX 318 318 ASP P 398 LEU P 412 1 15
HELIX 319 319 PRO P 415 ARG P 429 1 15
HELIX 320 320 ASP P 432 ASN P 447 1 16
HELIX 321 321 GLN P 448 GLY P 463 1 16
HELIX 322 322 MET P 468 LEU P 480 1 13
HELIX 323 323 GLU P 482 CYS P 500 1 19
HELIX 324 324 THR P 511 CYS P 523 1 13
HELIX 325 325 LEU P 525 ALA P 538 1 14
HELIX 326 326 ASN R 56 ARG R 63 1 8
HELIX 327 327 GLY R 88 LEU R 100 1 13
HELIX 328 328 SER R 154 SER R 163 1 10
HELIX 329 329 ARG S 358 ALA S 366 1 9
HELIX 330 330 LYS S 423 GLY S 432 1 10
HELIX 331 331 SER U 6 ALA U 21 1 16
HELIX 332 332 LYS W 12 ASP W 25 1 14
HELIX 333 333 ASN X 36 GLY X 48 1 13
HELIX 334 334 LEU X 49 ASN X 67 1 19
HELIX 335 335 SER X 72 ASP X 90 1 19
HELIX 336 336 GLU X 92 LEU X 110 1 19
HELIX 337 337 SER X 134 LYS X 150 1 17
HELIX 338 338 GLN X 151 GLY X 161 1 11
HELIX 339 339 THR X 168 GLY X 183 1 16
HELIX 340 340 GLN X 184 CYS X 199 1 16
HELIX 341 341 ALA X 202 SER X 213 1 12
HELIX 342 342 VAL X 214 THR X 229 1 16
HELIX 343 343 TRP X 235 GLY X 249 1 15
HELIX 344 344 ASP X 250 LYS X 264 1 15
HELIX 345 345 ASN X 270 GLY X 285 1 16
HELIX 346 346 ASP X 286 ASP X 301 1 16
HELIX 347 347 LEU X 304 GLY X 319 1 16
HELIX 348 348 ARG X 320 SER X 335 1 16
HELIX 349 349 HIS X 338 LYS X 353 1 16
HELIX 350 350 ARG X 354 ASN X 369 1 16
HELIX 351 351 VAL X 373 GLY X 387 1 15
HELIX 352 352 ARG X 388 ALA X 403 1 16
HELIX 353 353 ARG X 406 ASN X 421 1 16
HELIX 354 354 SER X 422 GLY X 438 1 17
HELIX 355 355 ALA X 441 ASP X 454 1 14
HELIX 356 356 THR X 457 GLU X 472 1 16
HELIX 357 357 TYR X 475 GLN X 490 1 16
HELIX 358 358 LYS X 491 GLN X 506 1 16
HELIX 359 359 CYS X 509 ASN X 523 1 15
HELIX 360 360 GLU X 524 ASP X 539 1 16
HELIX 361 361 ASN Y 36 GLY Y 48 1 13
HELIX 362 362 LEU Y 49 ASN Y 67 1 19
HELIX 363 363 SER Y 72 ASP Y 90 1 19
HELIX 364 364 GLU Y 92 LEU Y 110 1 19
HELIX 365 365 SER Y 134 LYS Y 150 1 17
HELIX 366 366 GLN Y 151 ILE Y 162 1 12
HELIX 367 367 THR Y 168 GLY Y 183 1 16
HELIX 368 368 GLN Y 184 CYS Y 199 1 16
HELIX 369 369 ALA Y 202 SER Y 213 1 12
HELIX 370 370 VAL Y 214 THR Y 229 1 16
HELIX 371 371 TRP Y 235 GLY Y 249 1 15
HELIX 372 372 ASP Y 250 LYS Y 264 1 15
HELIX 373 373 ASN Y 270 GLY Y 285 1 16
HELIX 374 374 ASP Y 286 ASP Y 301 1 16
HELIX 375 375 LEU Y 304 GLY Y 319 1 16
HELIX 376 376 ARG Y 320 SER Y 335 1 16
HELIX 377 377 HIS Y 338 LYS Y 353 1 16
HELIX 378 378 ARG Y 354 ASN Y 369 1 16
HELIX 379 379 SER Y 372 GLY Y 387 1 16
HELIX 380 380 ARG Y 388 ALA Y 403 1 16
HELIX 381 381 ARG Y 406 ASN Y 421 1 16
HELIX 382 382 SER Y 422 GLY Y 438 1 17
HELIX 383 383 ALA Y 441 ASP Y 454 1 14
HELIX 384 384 THR Y 457 GLU Y 472 1 16
HELIX 385 385 TYR Y 475 GLN Y 490 1 16
HELIX 386 386 LYS Y 491 GLN Y 506 1 16
HELIX 387 387 CYS Y 509 ASN Y 523 1 15
HELIX 388 388 GLU Y 524 ASP Y 539 1 16
HELIX 389 389 ASP Y 542 MET Y 552 1 11
SHEET 1 AA 4 LEU A 17 GLU A 19 0
SHEET 2 AA 4 MET A 604 THR A 608 -1 O ARG A 606 N GLN A 18
SHEET 3 AA 4 ARG A 594 LEU A 599 -1 O VAL A 595 N ILE A 607
SHEET 4 AA 4 ILE A 584 VAL A 591 -1 N HIS A 585 O GLU A 598
SHEET 1 AB 4 SER A 73 LYS A 78 0
SHEET 2 AB 4 ASP A 90 VAL A 95 -1 O GLU A 91 N ARG A 77
SHEET 3 AB 4 MET A 99 SER A 103 -1 O ILE A 101 N TYR A 94
SHEET 4 AB 4 LYS A 115 THR A 118 -1 O LYS A 115 N TRP A 102
SHEET 1 AC 4 LEU A 127 ILE A 132 0
SHEET 2 AC 4 VAL A 147 LEU A 154 -1 O GLU A 148 N PHE A 131
SHEET 3 AC 4 ILE A 159 SER A 163 -1 O ASN A 160 N ILE A 153
SHEET 4 AC 4 ASP A 168 ILE A 170 -1 O TYR A 169 N MET A 161
SHEET 1 AD 4 VAL A 177 VAL A 180 0
SHEET 2 AD 4 LEU A 187 ARG A 191 -1 O GLU A 190 N ALA A 178
SHEET 3 AD 4 MET A 210 MET A 213 -1 O PHE A 211 N PHE A 189
SHEET 4 AD 4 THR A 221 PRO A 222 -1 O THR A 221 N SER A 212
SHEET 1 AE 4 LYS A 245 ASN A 250 0
SHEET 2 AE 4 ILE A 255 ASP A 260 -1 O ILE A 255 N ASN A 250
SHEET 3 AE 4 VAL A 265 TRP A 269 -1 O VAL A 265 N ASP A 260
SHEET 4 AE 4 HIS A 411 TRP A 413 -1 N LEU A 412 O VAL A 268
SHEET 1 AF 4 VAL A 430 SER A 434 0
SHEET 2 AF 4 LYS A 440 VAL A 446 -1 O PHE A 441 N THR A 433
SHEET 3 AF 4 GLN A 451 GLU A 459 -1 O GLN A 451 N VAL A 446
SHEET 4 AF 4 LEU A 466 ILE A 474 -1 O ILE A 467 N GLN A 458
SHEET 1 AG 4 ASP A 478 VAL A 482 0
SHEET 2 AG 4 THR A 487 GLU A 492 -1 O THR A 487 N VAL A 482
SHEET 3 AG 4 ASN A 496 TYR A 500 -1 O ASN A 496 N GLU A 492
SHEET 4 AG 4 ARG A 505 LYS A 508 -1 N VAL A 506 O LEU A 499
SHEET 1 AH 2 THR A1108 ALA A1111 0
SHEET 2 AH 2 THR A1116 ASP A1119 -1 O THR A1116 N ALA A1111
SHEET 1 AI 2 TYR A1572 LEU A1574 0
SHEET 2 AI 2 ALA A1614 PRO A1616 -1 O GLU A1615 N SER A1573
SHEET 1 AJ 2 VAL A1620 VAL A1622 0
SHEET 2 AJ 2 VAL A1696 TYR A1698 1 O LEU A1697 N VAL A1622
SHEET 1 AK 4 GLN A1646 MET A1652 0
SHEET 2 AK 4 LEU A1633 LYS A1639 -1 O LEU A1634 N LEU A1651
SHEET 3 AK 4 LEU A1663 VAL A1668 -1 N LYS A1664 O LEU A1637
SHEET 4 AK 4 GLU A1675 ILE A1678 -1 O GLU A1675 N VAL A1668
SHEET 1 BA 3 VAL B 3 ASN B 9 0
SHEET 2 BA 3 LEU N 643 VAL N 648 -1 O LEU N 643 N ASN B 9
SHEET 3 BA 3 LEU N 655 SER N 656 -1 O LEU N 655 N VAL N 648
SHEET 1 BB 2 LEU B 46 TRP B 48 0
SHEET 2 BB 2 CYS B 54 HIS B 56 -1 O PHE B 55 N VAL B 47
SHEET 1 IA 4 ILE I 23 TRP I 28 0
SHEET 2 IA 4 ILE I 35 ASN I 39 -1 O ALA I 36 N VAL I 27
SHEET 3 IA 4 VAL I 44 HIS I 47 -1 O LEU I 45 N LEU I 37
SHEET 4 IA 4 ARG I 54 PHE I 58 -1 N VAL I 55 O LEU I 46
SHEET 1 IB 4 VAL I 68 TRP I 73 0
SHEET 2 IB 4 LEU I 79 LEU I 84 -1 O ALA I 81 N ALA I 72
SHEET 3 IB 4 ILE I 90 ASP I 94 -1 O VAL I 91 N PHE I 82
SHEET 4 IB 4 SER I 100 PHE I 104 -1 O HIS I 102 N LEU I 92
SHEET 1 IC 4 CYS I 112 GLU I 117 0
SHEET 2 IC 4 ASN I 174 GLY I 179 -1 O ILE I 175 N MET I 116
SHEET 3 IC 4 PHE I 184 ALA I 189 -1 O GLU I 186 N LEU I 178
SHEET 4 IC 4 PHE I 193 THR I 199 -1 O PHE I 193 N ALA I 189
SHEET 1 ID 4 THR I 204 LEU I 210 0
SHEET 2 ID 4 SER I 216 GLU I 222 -1 O SER I 218 N CYS I 209
SHEET 3 ID 4 TYR I 233 GLU I 237 -1 O PHE I 234 N VAL I 219
SHEET 4 ID 4 ALA I 551 ILE I 554 -1 O ILE I 552 N GLN I 235
SHEET 1 IE 2 SER I 229 GLU I 230 0
SHEET 2 IE 2 ARG I 558 ASP I 559 -1 O ASP I 559 N SER I 229
SHEET 1 IF 5 PHE I 574 ASN I 578 0
SHEET 2 IF 5 LEU I 583 LEU I 591 -1 O LEU I 583 N ASN I 578
SHEET 3 IF 5 TYR I 596 HIS I 604 -1 O LYS I 597 N ILE I 590
SHEET 4 IF 5 LEU I 615 THR I 624 -1 O ILE I 616 N ILE I 600
SHEET 5 IF 5 VAL I 631 ARG I 632 -1 O ARG I 632 N PHE I 623
SHEET 1 IG 5 PHE I 574 ASN I 578 0
SHEET 2 IG 5 LEU I 583 LEU I 591 -1 O LEU I 583 N ASN I 578
SHEET 3 IG 5 TYR I 596 HIS I 604 -1 O LYS I 597 N ILE I 590
SHEET 4 IG 5 LEU I 615 THR I 624 -1 O ILE I 616 N ILE I 600
SHEET 5 IG 5 THR I 702 PHE I 707 1 O ARG I 703 N LYS I 619
SHEET 1 IH 2 VAL I 631 ARG I 632 0
SHEET 2 IH 2 LEU I 615 THR I 624 -1 O PHE I 623 N ARG I 632
SHEET 1 II 4 TYR I 636 ASP I 645 0
SHEET 2 II 4 THR I 648 ASP I 655 -1 O THR I 648 N TYR I 644
SHEET 3 II 4 ARG I 664 PRO I 670 -1 O LEU I 665 N LEU I 653
SHEET 4 II 4 TRP I 711 LEU I 713 -1 O ARG I 712 N LEU I 666
SHEET 1 IJ 3 ALA I 719 GLY I 724 0
SHEET 2 IJ 3 VAL I 730 SER I 735 -1 O CYS I 732 N ALA I 723
SHEET 3 IJ 3 VAL I 741 GLU I 745 -1 O ARG I 742 N VAL I 733
SHEET 1 LA 4 VAL L 22 GLU L 24 0
SHEET 2 LA 4 GLN L 155 PRO L 161 -1 O THR L 160 N ARG L 23
SHEET 3 LA 4 THR L 76 TYR L 80 -1 O THR L 76 N TYR L 159
SHEET 4 LA 4 TRP L 119 PRO L 123 -1 O ILE L 120 N ILE L 79
SHEET 1 LB 5 VAL L 30 LEU L 33 0
SHEET 2 LB 5 HIS L 62 VAL L 74 -1 O ASN L 65 N SER L 32
SHEET 3 LB 5 THR L 132 VAL L 141 -1 O THR L 132 N VAL L 74
SHEET 4 LB 5 LYS L 93 GLY L 99 -1 O SER L 95 N ALA L 140
SHEET 5 LB 5 GLN L 106 GLU L 112 -1 O GLN L 106 N VAL L 98
SHEET 1 RA 4 LYS R 177 ASP R 180 0
SHEET 2 RA 4 THR R 466 ASN R 471 -1 O LEU R 467 N LEU R 179
SHEET 3 RA 4 ALA R 457 ALA R 462 -1 O ILE R 458 N TRP R 470
SHEET 4 RA 4 TYR R 448 MET R 451 -1 O TYR R 448 N GLY R 461
SHEET 1 RB 4 VAL R 193 TRP R 195 0
SHEET 2 RB 4 VAL R 200 LEU R 205 -1 O SER R 202 N ASP R 194
SHEET 3 RB 4 CYS R 208 SER R 213 -1 O CYS R 208 N LEU R 205
SHEET 4 RB 4 VAL R 219 ASP R 224 -1 O THR R 220 N LEU R 211
SHEET 1 RC 4 VAL R 232 TRP R 237 0
SHEET 2 RC 4 LEU R 243 THR R 248 -1 O ALA R 245 N GLY R 236
SHEET 3 RC 4 VAL R 253 ASP R 257 -1 O GLN R 254 N VAL R 246
SHEET 4 RC 4 LYS R 262 LEU R 267 -1 O LYS R 262 N ASP R 257
SHEET 1 RD 4 VAL R 274 ASN R 280 0
SHEET 2 RD 4 GLN R 283 SER R 288 -1 O GLN R 283 N ASN R 280
SHEET 3 RD 4 MET R 292 ASP R 297 -1 O MET R 292 N SER R 288
SHEET 4 RD 4 GLN R 304 LEU R 309 -1 N SER R 305 O GLN R 295
SHEET 1 RE 4 LEU R 319 TRP R 321 0
SHEET 2 RE 4 LEU R 327 GLY R 331 -1 O ALA R 329 N LYS R 320
SHEET 3 RE 4 LEU R 337 ASN R 341 -1 O LEU R 338 N SER R 330
SHEET 4 RE 4 GLN R 349 TYR R 351 -1 O GLN R 349 N VAL R 339
SHEET 1 RF 4 ALA R 360 TRP R 363 0
SHEET 2 RF 4 LEU R 370 GLY R 374 -1 O ALA R 372 N ALA R 362
SHEET 3 RF 4 CYS R 381 ASN R 386 -1 O ARG R 383 N SER R 373
SHEET 4 RF 4 PRO R 392 ASP R 397 -1 N LEU R 393 O PHE R 384
SHEET 1 RG 3 VAL R 402 TRP R 407 0
SHEET 2 RG 3 GLU R 413 HIS R 418 -1 O VAL R 415 N ALA R 406
SHEET 3 RG 3 ILE R 425 LYS R 429 -1 O LEU R 426 N SER R 416
SHEET 1 SA 4 LYS S 376 ALA S 377 0
SHEET 2 SA 4 PRO S 384 ASP S 388 -1 O ALA S 385 N LYS S 376
SHEET 3 SA 4 ARG S 393 CYS S 396 -1 O ARG S 393 N ASP S 388
SHEET 4 SA 4 ASP S 404 CYS S 406 -1 O TYR S 405 N ALA S 394
LINK ZN ZN B 101 SG CYS B 59 1555 1555 2.68
LINK ZN ZN B 101 SG CYS B 23 1555 1555 2.47
LINK ZN ZN B 101 SG CYS B 26 1555 1555 2.63
LINK ZN ZN B 102 SG CYS B 76 1555 1555 2.76
LINK ZN ZN B 102 SG CYS B 73 1555 1555 2.57
LINK ZN ZN B 102 ND1 HIS B 53 1555 1555 2.55
CISPEP 1 LEU A 1100 PRO A 1101 0 5.92
CISPEP 2 PRO A 1112 PRO A 1113 0 6.13
CISPEP 3 GLY A 1670 PRO A 1671 0 -7.37
CISPEP 4 SER A 1742 ALA A 1743 0 18.78
CISPEP 5 TRP B 14 LEU B 15 0 -0.30
CISPEP 6 GLN B 68 VAL B 69 0 -9.34
CISPEP 7 VAL C 96 LYS C 97 0 20.16
CISPEP 8 ASN C 361 PRO C 362 0 -15.40
CISPEP 9 ASN F 145 PRO F 146 0 -22.19
CISPEP 10 ASN H 145 PRO H 146 0 -17.65
CISPEP 11 PRO I 489 PRO I 490 0 18.23
CISPEP 12 PHE I 572 PRO I 573 0 0.57
CISPEP 13 GLN L 60 PRO L 61 0 5.33
CISPEP 14 THR L 125 ASP L 126 0 -9.49
CISPEP 15 PRO L 170 ARG L 171 0 -2.94
CISPEP 16 TYR N 125 LEU N 126 0 3.64
CISPEP 17 THR N 165 PRO N 166 0 -25.30
CISPEP 18 PRO N 197 GLU N 198 0 -3.68
CISPEP 19 SER N 284 PHE N 285 0 12.69
CISPEP 20 ASP N 350 PHE N 351 0 -26.14
CISPEP 21 THR N 368 ASP N 369 0 2.72
CISPEP 22 GLU N 478 ASP N 479 0 -4.19
CISPEP 23 ASP N 483 PRO N 484 0 28.27
CISPEP 24 SER N 493 SER N 494 0 -27.05
CISPEP 25 SER N 532 PHE N 533 0 -11.64
CISPEP 26 GLY N 550 GLU N 551 0 -16.17
CISPEP 27 PRO N 709 PRO N 710 0 -8.11
CISPEP 28 GLU O 123 PRO O 124 0 -6.14
CISPEP 29 ASP O 356 SER O 357 0 8.09
CISPEP 30 VAL P 96 LYS P 97 0 21.63
CISPEP 31 ASN P 361 PRO P 362 0 -17.79
CISPEP 32 LEU R 127 PHE R 128 0 24.92
CISPEP 33 TYR R 420 SER R 421 0 -10.99
CISPEP 34 SER R 484 VAL R 485 0 -20.75
CISPEP 35 PHE S 321 ARG S 322 0 -1.57
CISPEP 36 LEU T 7 ALA T 8 0 -4.19
CISPEP 37 ALA T 11 ALA T 12 0 5.45
CISPEP 38 CYS Y 199 PRO Y 200 0 -21.23
SITE 1 AC1 4 CYS B 23 CYS B 26 HIS B 56 CYS B 59
SITE 1 AC2 4 CYS B 51 HIS B 53 CYS B 73 CYS B 76
SITE 1 AC3 4 CYS B 34 CYS B 37 CYS B 44 HIS B 58
SITE 1 AC4 5 CYS S 378 ARG S 380 CYS S 381 CYS S 396
SITE 2 AC4 5 CYS S 401
SITE 1 AC5 4 CYS S 406 CYS S 409 HIS S 414 CYS S 419
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
(ATOM LINES ARE NOT SHOWN.)
END
