GenomeNet

Database: PDB
Entry: 4UM8
LinkDB: 4UM8
Original site: 4UM8 
HEADER    IMMUNE SYSTEM                           15-MAY-14   4UM8              
TITLE     CRYSTAL STRUCTURE OF ALPHA V BETA 6                                   
CAVEAT     4UM8    NAG C 3266 IS PLANAR AT C-ALPHA                              
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: INTEGRIN ALPHA-V;                                          
COMPND   3 CHAIN: A, C;                                                         
COMPND   4 FRAGMENT: HEADPIECE, RESIDUES 31-625;                                
COMPND   5 SYNONYM: VITRONECTIN RECEPTOR SUBUNIT ALPHA, INTEGRIN ALPHA V;       
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MUTATION: YES;                                                       
COMPND   8 MOL_ID: 2;                                                           
COMPND   9 MOLECULE: INTEGRIN BETA-6;                                           
COMPND  10 CHAIN: B, D;                                                         
COMPND  11 SYNONYM: INTEGRIN BETA 6;                                            
COMPND  12 ENGINEERED: YES;                                                     
COMPND  13 MUTATION: YES                                                        
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   6 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   8 EXPRESSION_SYSTEM_CELL_LINE: HEK293S GNT I- CELL;                    
SOURCE   9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  10 EXPRESSION_SYSTEM_PLASMID: PCDNA 3.1 AND ET10;                       
SOURCE  11 MOL_ID: 2;                                                           
SOURCE  12 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  13 ORGANISM_COMMON: HUMAN;                                              
SOURCE  14 ORGANISM_TAXID: 9606;                                                
SOURCE  15 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  16 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  17 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  18 EXPRESSION_SYSTEM_CELL_LINE: HEK293S GNT I- CELL;                    
SOURCE  19 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID;                              
SOURCE  20 EXPRESSION_SYSTEM_PLASMID: PCDNA 3.1 AND ET10                        
KEYWDS    IMMUNE SYSTEM, CELL SURFACE RECEPTOR                                  
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    X.DONG,T.A.SPRINGER                                                   
REVDAT   3   17-DEC-14 4UM8    1       JRNL                                     
REVDAT   2   19-NOV-14 4UM8    1       JRNL                                     
REVDAT   1   12-NOV-14 4UM8    0                                                
JRNL        AUTH   X.DONG,N.E.HUDSON,C.LU,T.A.SPRINGER                          
JRNL        TITL   STRUCTURAL DETERMINANTS OF INTEGRIN BETA-SUBUNIT             
JRNL        TITL 2 SPECIFICITY FOR LATENT TGF-BETA                              
JRNL        REF    NAT.STRUCT.MOL.BIOL.          V.  21  1091 2014              
JRNL        REFN                   ISSN 1545-9993                               
JRNL        PMID   25383667                                                     
JRNL        DOI    10.1038/NSMB.2905                                            
REMARK   2                                                                      
REMARK   2 RESOLUTION.    2.85 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (PHENIX.REFINE)                               
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VICENT CHEN,IAN             
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 2.852                          
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 48.656                         
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.99                           
REMARK   3   COMPLETENESS FOR RANGE        (%) : 96.38                          
REMARK   3   NUMBER OF REFLECTIONS             : 69912                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.2395                          
REMARK   3   R VALUE            (WORKING SET) : 0.2384                          
REMARK   3   FREE R VALUE                     : 0.2808                          
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 2.6                             
REMARK   3   FREE R VALUE TEST SET COUNT      : 1799                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 48.6629 -  6.7007    0.93     5157   131  0.2077 0.2467        
REMARK   3     2  6.7007 -  5.3207    0.96     5262   140  0.2168 0.2536        
REMARK   3     3  5.3207 -  4.6487    0.97     5271   141  0.1755 0.2130        
REMARK   3     4  4.6487 -  4.2240    0.98     5346   140  0.1700 0.2128        
REMARK   3     5  4.2240 -  3.9213    0.98     5333   137  0.2084 0.2428        
REMARK   3     6  3.9213 -  3.6902    0.99     5349   146  0.2325 0.3211        
REMARK   3     7  3.6902 -  3.5055    0.99     5377   142  0.2532 0.3403        
REMARK   3     8  3.5055 -  3.3529    0.99     5345   140  0.2817 0.3341        
REMARK   3     9  3.3529 -  3.2239    0.99     5359   141  0.3078 0.3578        
REMARK   3    10  3.2239 -  3.1126    0.99     5347   141  0.3225 0.3546        
REMARK   3    11  3.1126 -  3.0153    0.99     5392   140  0.3497 0.3403        
REMARK   3    12  3.0153 -  2.9291    0.99     5331   141  0.3798 0.4010        
REMARK   3    13  2.9291 -  2.8520    0.78     4244   119  0.4108 0.4170        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : 1                                             
REMARK   3   B_SOL              : 1                                             
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.58             
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 34.21            
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : 61.12                          
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : 86.6                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.004          16785                                  
REMARK   3   ANGLE     :  0.718          22692                                  
REMARK   3   CHIRALITY :  0.054           2666                                  
REMARK   3   PLANARITY :  0.002           2877                                  
REMARK   3   DIHEDRAL  : 10.205           6234                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : 10                                         
REMARK   3   TLS GROUP : 1                                                      
REMARK   3    SELECTION: CHAIN A AND RESSEQ 1:438                               
REMARK   3    ORIGIN FOR THE GROUP (A):  13.0669  18.0222  17.2921              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.3045 T22:   0.4647                                     
REMARK   3      T33:   0.4505 T12:  -0.0140                                     
REMARK   3      T13:   0.0111 T23:   0.0747                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.2257 L22:   2.1345                                     
REMARK   3      L33:   3.2702 L12:   0.2300                                     
REMARK   3      L13:  -0.4467 L23:  -0.6602                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.1001 S12:   0.0795 S13:   0.0343                       
REMARK   3      S21:   0.0655 S22:   0.3472 S23:   0.3130                       
REMARK   3      S31:   0.2218 S32:  -0.6795 S33:  -0.2053                       
REMARK   3   TLS GROUP : 2                                                      
REMARK   3    SELECTION: CHAIN A AND RESSEQ 439:594                             
REMARK   3    ORIGIN FOR THE GROUP (A):  22.2367  59.0107 -14.2397              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5545 T22:   0.4772                                     
REMARK   3      T33:   0.6721 T12:  -0.2191                                     
REMARK   3      T13:  -0.0606 T23:   0.0304                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   5.5693 L22:   3.7995                                     
REMARK   3      L33:   5.5528 L12:   3.2811                                     
REMARK   3      L13:  -5.0208 L23:  -4.3310                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.0838 S12:  -0.2699 S13:   0.0088                       
REMARK   3      S21:  -0.1187 S22:  -0.0981 S23:  -0.2384                       
REMARK   3      S31:  -0.0921 S32:   0.5741 S33:   0.2115                       
REMARK   3   TLS GROUP : 3                                                      
REMARK   3    SELECTION: CHAIN B AND (RESSEQ 57:108 OR RESSEQ 353:433)          
REMARK   3    ORIGIN FOR THE GROUP (A):  60.3373  25.8354  13.6371              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.5760 T22:   0.8089                                     
REMARK   3      T33:   0.5339 T12:   0.0550                                     
REMARK   3      T13:   0.0316 T23:  -0.2277                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   3.9486 L22:   8.6226                                     
REMARK   3      L33:   7.6331 L12:  -0.7129                                     
REMARK   3      L13:   1.4501 L23:  -4.8266                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0943 S12:  -0.2897 S13:   0.3649                       
REMARK   3      S21:  -0.3726 S22:  -0.2213 S23:  -0.5659                       
REMARK   3      S31:   0.1542 S32:   0.7238 S33:   0.1140                       
REMARK   3   TLS GROUP : 4                                                      
REMARK   3    SELECTION: CHAIN B AND RESSEQ 1:56                                
REMARK   3    ORIGIN FOR THE GROUP (A):  58.3868  49.3388  -8.3012              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.8958 T22:   1.2287                                     
REMARK   3      T33:   1.4793 T12:  -0.4354                                     
REMARK   3      T13:   0.0150 T23:   0.2721                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.8374 L22:   2.0243                                     
REMARK   3      L33:   9.3168 L12:  -0.2768                                     
REMARK   3      L13:  -0.1148 L23:  -1.0001                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.3266 S12:   0.6220 S13:   1.6333                       
REMARK   3      S21:  -2.1762 S22:  -0.4624 S23:  -1.4888                       
REMARK   3      S31:  -1.9542 S32:   1.4083 S33:   0.6626                       
REMARK   3   TLS GROUP : 5                                                      
REMARK   3    SELECTION: CHAIN B AND RESSEQ 434:472                             
REMARK   3    ORIGIN FOR THE GROUP (A):  57.4312  52.2668   4.1545              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.6525 T22:   1.5977                                     
REMARK   3      T33:   2.0838 T12:  -0.3713                                     
REMARK   3      T13:   0.3341 T23:  -0.0808                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   0.3940 L22:   6.0045                                     
REMARK   3      L33:   0.0558 L12:  -1.4488                                     
REMARK   3      L13:   0.1356 L23:  -0.5771                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.3475 S12:   0.6695 S13:   1.0574                       
REMARK   3      S21:  -0.4672 S22:   0.2396 S23:  -0.9848                       
REMARK   3      S31:  -0.0880 S32:   1.6196 S33:  -0.6614                       
REMARK   3   TLS GROUP : 6                                                      
REMARK   3    SELECTION: CHAIN C AND RESSEQ 1:438                               
REMARK   3    ORIGIN FOR THE GROUP (A):  63.1915   7.1297  76.6488              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6401 T22:   1.5768                                     
REMARK   3      T33:   0.7310 T12:   0.1710                                     
REMARK   3      T13:  -0.2558 T23:  -0.4036                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.1384 L22:   2.2948                                     
REMARK   3      L33:   1.8552 L12:   0.2788                                     
REMARK   3      L13:   0.3438 L23:   0.2599                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.0559 S12:  -0.0714 S13:  -0.1052                       
REMARK   3      S21:   0.6267 S22:   0.4596 S23:  -0.6995                       
REMARK   3      S31:   0.0598 S32:   1.3027 S33:  -0.2876                       
REMARK   3   TLS GROUP : 7                                                      
REMARK   3    SELECTION: CHAIN C AND RESSEQ 439:594                             
REMARK   3    ORIGIN FOR THE GROUP (A):  65.5128 -34.7356  44.5097              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.6226 T22:   1.1603                                     
REMARK   3      T33:   0.7352 T12:   0.1443                                     
REMARK   3      T13:   0.1893 T23:  -0.0776                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.5753 L22:   4.8805                                     
REMARK   3      L33:   4.4665 L12:  -0.8599                                     
REMARK   3      L13:   1.6641 L23:   3.0674                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:  -0.4711 S12:  -0.9381 S13:   0.0157                       
REMARK   3      S21:   0.2841 S22:   0.3542 S23:  -0.2289                       
REMARK   3      S31:   0.0133 S32:  -0.3782 S33:   0.2120                       
REMARK   3   TLS GROUP : 8                                                      
REMARK   3    SELECTION: CHAIN D AND (RESSEQ 57:108 OR RESSEQ 353:433)          
REMARK   3    ORIGIN FOR THE GROUP (A):  19.5002  -2.0230  59.0583              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   0.4819 T22:   0.5316                                     
REMARK   3      T33:   0.6184 T12:  -0.0661                                     
REMARK   3      T13:   0.0002 T23:   0.2203                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   4.4743 L22:   8.6699                                     
REMARK   3      L33:   6.4342 L12:  -2.1548                                     
REMARK   3      L13:  -1.3645 L23:   4.2653                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2678 S12:  -0.4094 S13:  -0.3111                       
REMARK   3      S21:  -0.3420 S22:  -0.2677 S23:   0.6278                       
REMARK   3      S31:   0.1455 S32:  -0.5154 S33:  -0.0260                       
REMARK   3   TLS GROUP : 9                                                      
REMARK   3    SELECTION: CHAIN D AND RESSEQ 1:56                                
REMARK   3    ORIGIN FOR THE GROUP (A):  28.9503 -25.1255  40.0853              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.0730 T22:   0.7807                                     
REMARK   3      T33:   1.4333 T12:   0.1659                                     
REMARK   3      T13:   0.0473 T23:  -0.1887                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   1.9929 L22:   9.1614                                     
REMARK   3      L33:   5.5539 L12:  -1.0688                                     
REMARK   3      L13:   1.9104 L23:   1.7738                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.1161 S12:   0.1937 S13:  -1.1753                       
REMARK   3      S21:  -0.7351 S22:   0.4576 S23:  -0.9065                       
REMARK   3      S31:   0.7891 S32:   0.1634 S33:  -0.6910                       
REMARK   3   TLS GROUP : 10                                                     
REMARK   3    SELECTION: CHAIN D AND RESSEQ 434:472                             
REMARK   3    ORIGIN FOR THE GROUP (A):  25.8374 -28.7782  51.0723              
REMARK   3    T TENSOR                                                          
REMARK   3      T11:   1.1221 T22:   1.5924                                     
REMARK   3      T33:   1.8919 T12:  -0.1545                                     
REMARK   3      T13:  -0.3984 T23:   0.0562                                     
REMARK   3    L TENSOR                                                          
REMARK   3      L11:   2.2314 L22:   7.4937                                     
REMARK   3      L33:   1.7950 L12:   3.9628                                     
REMARK   3      L13:   0.7262 L23:   2.1342                                     
REMARK   3    S TENSOR                                                          
REMARK   3      S11:   0.2271 S12:   0.4287 S13:  -2.2657                       
REMARK   3      S21:   0.0333 S22:   1.6842 S23:   0.2829                       
REMARK   3      S31:  -0.9414 S32:  -1.6517 S33:  -1.8592                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 4UM8 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 16-MAY-14.                  
REMARK 100 THE PDBE ID CODE IS EBI-60639.                                       
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 15-JUL-12                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 6.0                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 23-ID-D                            
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9796                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : MARRESEARCH                        
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : XDS                                
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 69912                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 2.85                               
REMARK 200  RESOLUTION RANGE LOW       (A) : 50.00                              
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : 0.33                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 97.4                               
REMARK 200  DATA REDUNDANCY                : 2.4                                
REMARK 200  R MERGE                    (I) : 0.18                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 4.80                               
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 2.85                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.92                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : 91.0                               
REMARK 200  DATA REDUNDANCY IN SHELL       : 2.3                                
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : 0.33                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: PDB ENTRY 4G1M                                       
REMARK 200                                                                      
REMARK 200 REMARK: NONE                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 52                                        
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.6                      
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 15% PEG 4000, 0.1 M                      
REMARK 280  NACACODYLATE, PH 6.0                                                
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1                          
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y,-Z                                                 
REMARK 290       3555   X+1/2,Y+1/2,Z                                           
REMARK 290       4555   -X+1/2,Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000       92.22500            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000       85.00500            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000       92.22500            
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000       85.00500            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2                                                    
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 10240 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 45100 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: 6.7 KCAL/MOL                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 11000 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 45660 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: 41.3 KCAL/MOL                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 375                                                                      
REMARK 375 SPECIAL POSITION                                                     
REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS            
REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL          
REMARK 375 POSITIONS.                                                           
REMARK 375                                                                      
REMARK 375 ATOM RES CSSEQI                                                      
REMARK 375  S   SO4 A1596   LIES ON A SPECIAL POSITION.                         
REMARK 375 CL    CL C1595   LIES ON A SPECIAL POSITION.                         
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     GLN A   504                                                      
REMARK 465     LYS A   505                                                      
REMARK 465     GLY A   506                                                      
REMARK 465     ASP A   595                                                      
REMARK 465     THR A   596                                                      
REMARK 465     GLY A   597                                                      
REMARK 465     GLY A   598                                                      
REMARK 465     LEU A   599                                                      
REMARK 465     GLU A   600                                                      
REMARK 465     VAL A   601                                                      
REMARK 465     LEU A   602                                                      
REMARK 465     PHE A   603                                                      
REMARK 465     GLN A   604                                                      
REMARK 465     GLY A   605                                                      
REMARK 465     PRO A   606                                                      
REMARK 465     GLY A   607                                                      
REMARK 465     GLU A   608                                                      
REMARK 465     ASN A   609                                                      
REMARK 465     ALA A   610                                                      
REMARK 465     GLN A   611                                                      
REMARK 465     LEU A   612                                                      
REMARK 465     GLU A   613                                                      
REMARK 465     LYS A   614                                                      
REMARK 465     GLU A   615                                                      
REMARK 465     LEU A   616                                                      
REMARK 465     GLN A   617                                                      
REMARK 465     ALA A   618                                                      
REMARK 465     LEU A   619                                                      
REMARK 465     GLU A   620                                                      
REMARK 465     LYS A   621                                                      
REMARK 465     GLU A   622                                                      
REMARK 465     ASN A   623                                                      
REMARK 465     ALA A   624                                                      
REMARK 465     GLN A   625                                                      
REMARK 465     LEU A   626                                                      
REMARK 465     GLU A   627                                                      
REMARK 465     TRP A   628                                                      
REMARK 465     GLU A   629                                                      
REMARK 465     LEU A   630                                                      
REMARK 465     GLN A   631                                                      
REMARK 465     ALA A   632                                                      
REMARK 465     LEU A   633                                                      
REMARK 465     GLU A   634                                                      
REMARK 465     LYS A   635                                                      
REMARK 465     GLU A   636                                                      
REMARK 465     LEU A   637                                                      
REMARK 465     ALA A   638                                                      
REMARK 465     GLN A   639                                                      
REMARK 465     THR A   640                                                      
REMARK 465     THR A   641                                                      
REMARK 465     GLY A   642                                                      
REMARK 465     TRP A   643                                                      
REMARK 465     ARG A   644                                                      
REMARK 465     GLY A   645                                                      
REMARK 465     GLY A   646                                                      
REMARK 465     HIS A   647                                                      
REMARK 465     VAL A   648                                                      
REMARK 465     VAL A   649                                                      
REMARK 465     GLU A   650                                                      
REMARK 465     GLY A   651                                                      
REMARK 465     LEU A   652                                                      
REMARK 465     ALA A   653                                                      
REMARK 465     GLY A   654                                                      
REMARK 465     GLU A   655                                                      
REMARK 465     LEU A   656                                                      
REMARK 465     GLU A   657                                                      
REMARK 465     GLN A   658                                                      
REMARK 465     LEU A   659                                                      
REMARK 465     ARG A   660                                                      
REMARK 465     ALA A   661                                                      
REMARK 465     ARG A   662                                                      
REMARK 465     LEU A   663                                                      
REMARK 465     GLU A   664                                                      
REMARK 465     HIS A   665                                                      
REMARK 465     HIS A   666                                                      
REMARK 465     PRO A   667                                                      
REMARK 465     GLN A   668                                                      
REMARK 465     GLY A   669                                                      
REMARK 465     GLN A   670                                                      
REMARK 465     ARG A   671                                                      
REMARK 465     GLU A   672                                                      
REMARK 465     PRO A   673                                                      
REMARK 465     ALA A   674                                                      
REMARK 465     GLY A   675                                                      
REMARK 465     HIS A   676                                                      
REMARK 465     HIS A   677                                                      
REMARK 465     HIS A   678                                                      
REMARK 465     HIS A   679                                                      
REMARK 465     HIS A   680                                                      
REMARK 465     HIS A   681                                                      
REMARK 465     MET B   -16                                                      
REMARK 465     GLY B   -15                                                      
REMARK 465     ILE B   -14                                                      
REMARK 465     GLU B   -13                                                      
REMARK 465     LEU B   -12                                                      
REMARK 465     LEU B   -11                                                      
REMARK 465     CYS B   -10                                                      
REMARK 465     LEU B    -9                                                      
REMARK 465     PHE B    -8                                                      
REMARK 465     PHE B    -7                                                      
REMARK 465     LEU B    -6                                                      
REMARK 465     PHE B    -5                                                      
REMARK 465     LEU B    -4                                                      
REMARK 465     GLY B    -3                                                      
REMARK 465     ARG B    -2                                                      
REMARK 465     ASN B    -1                                                      
REMARK 465     ASP B     0                                                      
REMARK 465     HIS B     1                                                      
REMARK 465     VAL B     2                                                      
REMARK 465     GLN B     3                                                      
REMARK 465     GLY B     4                                                      
REMARK 465     ALA B    11                                                      
REMARK 465     GLU B    12                                                      
REMARK 465     GLN B    29                                                      
REMARK 465     GLU B    30                                                      
REMARK 465     ASN B    31                                                      
REMARK 465     PHE B    32                                                      
REMARK 465     THR B    33                                                      
REMARK 465     HIS B    34                                                      
REMARK 465     PRO B    35                                                      
REMARK 465     SER B    36                                                      
REMARK 465     GLY B    37                                                      
REMARK 465     VAL B    38                                                      
REMARK 465     GLY B    39                                                      
REMARK 465     GLU B    40                                                      
REMARK 465     GLU B   442                                                      
REMARK 465     VAL B   443                                                      
REMARK 465     GLU B   444                                                      
REMARK 465     VAL B   445                                                      
REMARK 465     ASN B   446                                                      
REMARK 465     SER B   447                                                      
REMARK 465     SER B   448                                                      
REMARK 465     LYS B   449                                                      
REMARK 465     CYS B   450                                                      
REMARK 465     HIS B   451                                                      
REMARK 465     HIS B   452                                                      
REMARK 465     GLY B   453                                                      
REMARK 465     ASN B   454                                                      
REMARK 465     GLY B   455                                                      
REMARK 465     SER B   456                                                      
REMARK 465     PHE B   457                                                      
REMARK 465     GLN B   458                                                      
REMARK 465     CYS B   459                                                      
REMARK 465     GLY B   460                                                      
REMARK 465     VAL B   461                                                      
REMARK 465     CYS B   462                                                      
REMARK 465     ALA B   463                                                      
REMARK 465     CYS B   464                                                      
REMARK 465     HIS B   465                                                      
REMARK 465     PRO B   466                                                      
REMARK 465     GLY B   467                                                      
REMARK 465     HIS B   468                                                      
REMARK 465     MET B   469                                                      
REMARK 465     GLY B   470                                                      
REMARK 465     PRO B   471                                                      
REMARK 465     ARG B   472                                                      
REMARK 465     CYS B   473                                                      
REMARK 465     GLU B   474                                                      
REMARK 465     CYS B   475                                                      
REMARK 465     GLY B   476                                                      
REMARK 465     GLU B   477                                                      
REMARK 465     ASP B   478                                                      
REMARK 465     MET B   479                                                      
REMARK 465     LEU B   480                                                      
REMARK 465     SER B   481                                                      
REMARK 465     THR B   482                                                      
REMARK 465     ASP B   483                                                      
REMARK 465     SER B   484                                                      
REMARK 465     CYS B   485                                                      
REMARK 465     LYS B   486                                                      
REMARK 465     GLU B   487                                                      
REMARK 465     ALA B   488                                                      
REMARK 465     PRO B   489                                                      
REMARK 465     ASP B   490                                                      
REMARK 465     HIS B   491                                                      
REMARK 465     PRO B   492                                                      
REMARK 465     SER B   493                                                      
REMARK 465     CYS B   494                                                      
REMARK 465     SER B   495                                                      
REMARK 465     GLY B   496                                                      
REMARK 465     ARG B   497                                                      
REMARK 465     GLY B   498                                                      
REMARK 465     ASP B   499                                                      
REMARK 465     CYS B   500                                                      
REMARK 465     TYR B   501                                                      
REMARK 465     CYS B   502                                                      
REMARK 465     GLY B   503                                                      
REMARK 465     GLN B   504                                                      
REMARK 465     CYS B   505                                                      
REMARK 465     ILE B   506                                                      
REMARK 465     CYS B   507                                                      
REMARK 465     HIS B   508                                                      
REMARK 465     LEU B   509                                                      
REMARK 465     SER B   510                                                      
REMARK 465     PRO B   511                                                      
REMARK 465     TYR B   512                                                      
REMARK 465     GLY B   513                                                      
REMARK 465     ASN B   514                                                      
REMARK 465     ILE B   515                                                      
REMARK 465     TYR B   516                                                      
REMARK 465     GLY B   517                                                      
REMARK 465     PRO B   518                                                      
REMARK 465     TYR B   519                                                      
REMARK 465     CYS B   520                                                      
REMARK 465     GLN B   521                                                      
REMARK 465     CYS B   522                                                      
REMARK 465     ASP B   523                                                      
REMARK 465     ASN B   524                                                      
REMARK 465     PHE B   525                                                      
REMARK 465     SER B   526                                                      
REMARK 465     CYS B   527                                                      
REMARK 465     VAL B   528                                                      
REMARK 465     ARG B   529                                                      
REMARK 465     HIS B   530                                                      
REMARK 465     LYS B   531                                                      
REMARK 465     GLY B   532                                                      
REMARK 465     LEU B   533                                                      
REMARK 465     LEU B   534                                                      
REMARK 465     CYS B   535                                                      
REMARK 465     GLY B   536                                                      
REMARK 465     GLY B   537                                                      
REMARK 465     ASN B   538                                                      
REMARK 465     GLY B   539                                                      
REMARK 465     ASP B   540                                                      
REMARK 465     CYS B   541                                                      
REMARK 465     ASP B   542                                                      
REMARK 465     CYS B   543                                                      
REMARK 465     GLY B   544                                                      
REMARK 465     GLU B   545                                                      
REMARK 465     CYS B   546                                                      
REMARK 465     VAL B   547                                                      
REMARK 465     CYS B   548                                                      
REMARK 465     ARG B   549                                                      
REMARK 465     SER B   550                                                      
REMARK 465     GLY B   551                                                      
REMARK 465     TRP B   552                                                      
REMARK 465     THR B   553                                                      
REMARK 465     GLY B   554                                                      
REMARK 465     GLU B   555                                                      
REMARK 465     TYR B   556                                                      
REMARK 465     CYS B   557                                                      
REMARK 465     ASN B   558                                                      
REMARK 465     CYS B   559                                                      
REMARK 465     THR B   560                                                      
REMARK 465     THR B   561                                                      
REMARK 465     SER B   562                                                      
REMARK 465     THR B   563                                                      
REMARK 465     ASP B   564                                                      
REMARK 465     SER B   565                                                      
REMARK 465     CYS B   566                                                      
REMARK 465     VAL B   567                                                      
REMARK 465     SER B   568                                                      
REMARK 465     GLU B   569                                                      
REMARK 465     ASP B   570                                                      
REMARK 465     GLY B   571                                                      
REMARK 465     VAL B   572                                                      
REMARK 465     LEU B   573                                                      
REMARK 465     CYS B   574                                                      
REMARK 465     SER B   575                                                      
REMARK 465     GLY B   576                                                      
REMARK 465     ARG B   577                                                      
REMARK 465     GLY B   578                                                      
REMARK 465     ASP B   579                                                      
REMARK 465     CYS B   580                                                      
REMARK 465     VAL B   581                                                      
REMARK 465     CYS B   582                                                      
REMARK 465     GLY B   583                                                      
REMARK 465     LYS B   584                                                      
REMARK 465     CYS B   585                                                      
REMARK 465     VAL B   586                                                      
REMARK 465     CYS B   587                                                      
REMARK 465     THR B   588                                                      
REMARK 465     ASN B   589                                                      
REMARK 465     PRO B   590                                                      
REMARK 465     GLY B   591                                                      
REMARK 465     ALA B   592                                                      
REMARK 465     SER B   593                                                      
REMARK 465     GLY B   594                                                      
REMARK 465     PRO B   595                                                      
REMARK 465     THR B   596                                                      
REMARK 465     CYS B   597                                                      
REMARK 465     GLU B   598                                                      
REMARK 465     ARG B   599                                                      
REMARK 465     CYS B   600                                                      
REMARK 465     PRO B   601                                                      
REMARK 465     THR B   602                                                      
REMARK 465     CYS B   603                                                      
REMARK 465     GLY B   604                                                      
REMARK 465     ASP B   605                                                      
REMARK 465     PRO B   606                                                      
REMARK 465     CYS B   607                                                      
REMARK 465     ASN B   608                                                      
REMARK 465     SER B   609                                                      
REMARK 465     LYS B   610                                                      
REMARK 465     ARG B   611                                                      
REMARK 465     SER B   612                                                      
REMARK 465     CYS B   613                                                      
REMARK 465     ILE B   614                                                      
REMARK 465     GLU B   615                                                      
REMARK 465     CYS B   616                                                      
REMARK 465     HIS B   617                                                      
REMARK 465     LEU B   618                                                      
REMARK 465     SER B   619                                                      
REMARK 465     ALA B   620                                                      
REMARK 465     ALA B   621                                                      
REMARK 465     GLY B   622                                                      
REMARK 465     GLN B   623                                                      
REMARK 465     ALA B   624                                                      
REMARK 465     ARG B   625                                                      
REMARK 465     GLU B   626                                                      
REMARK 465     GLU B   627                                                      
REMARK 465     CYS B   628                                                      
REMARK 465     VAL B   629                                                      
REMARK 465     ASP B   630                                                      
REMARK 465     LYS B   631                                                      
REMARK 465     CYS B   632                                                      
REMARK 465     LYS B   633                                                      
REMARK 465     LEU B   634                                                      
REMARK 465     ALA B   635                                                      
REMARK 465     GLY B   636                                                      
REMARK 465     ALA B   637                                                      
REMARK 465     THR B   638                                                      
REMARK 465     ILE B   639                                                      
REMARK 465     SER B   640                                                      
REMARK 465     GLU B   641                                                      
REMARK 465     GLU B   642                                                      
REMARK 465     GLU B   643                                                      
REMARK 465     ASP B   644                                                      
REMARK 465     PHE B   645                                                      
REMARK 465     SER B   646                                                      
REMARK 465     LYS B   647                                                      
REMARK 465     ASP B   648                                                      
REMARK 465     GLY B   649                                                      
REMARK 465     SER B   650                                                      
REMARK 465     VAL B   651                                                      
REMARK 465     SER B   652                                                      
REMARK 465     CYS B   653                                                      
REMARK 465     SER B   654                                                      
REMARK 465     LEU B   655                                                      
REMARK 465     GLN B   656                                                      
REMARK 465     GLY B   657                                                      
REMARK 465     GLU B   658                                                      
REMARK 465     ASN B   659                                                      
REMARK 465     GLU B   660                                                      
REMARK 465     CYS B   661                                                      
REMARK 465     LEU B   662                                                      
REMARK 465     ILE B   663                                                      
REMARK 465     THR B   664                                                      
REMARK 465     PHE B   665                                                      
REMARK 465     LEU B   666                                                      
REMARK 465     ILE B   667                                                      
REMARK 465     THR B   668                                                      
REMARK 465     THR B   669                                                      
REMARK 465     ASP B   670                                                      
REMARK 465     ASN B   671                                                      
REMARK 465     GLU B   672                                                      
REMARK 465     GLY B   673                                                      
REMARK 465     LYS B   674                                                      
REMARK 465     THR B   675                                                      
REMARK 465     ILE B   676                                                      
REMARK 465     ILE B   677                                                      
REMARK 465     HIS B   678                                                      
REMARK 465     SER B   679                                                      
REMARK 465     ILE B   680                                                      
REMARK 465     ASN B   681                                                      
REMARK 465     GLU B   682                                                      
REMARK 465     LYS B   683                                                      
REMARK 465     ASP B   684                                                      
REMARK 465     CYS B   685                                                      
REMARK 465     PRO B   686                                                      
REMARK 465     LYS B   687                                                      
REMARK 465     PRO B   688                                                      
REMARK 465     PRO B   689                                                      
REMARK 465     ASN B   690                                                      
REMARK 465     ILE B   691                                                      
REMARK 465     PRO B   692                                                      
REMARK 465     MET B   693                                                      
REMARK 465     ILE B   694                                                      
REMARK 465     MET B   695                                                      
REMARK 465     LEU B   696                                                      
REMARK 465     GLY B   697                                                      
REMARK 465     VAL B   698                                                      
REMARK 465     SER B   699                                                      
REMARK 465     LEU B   700                                                      
REMARK 465     ALA B   701                                                      
REMARK 465     ILE B   702                                                      
REMARK 465     LEU B   703                                                      
REMARK 465     LEU B   704                                                      
REMARK 465     ILE B   705                                                      
REMARK 465     GLY B   706                                                      
REMARK 465     VAL B   707                                                      
REMARK 465     VAL B   708                                                      
REMARK 465     LEU B   709                                                      
REMARK 465     LEU B   710                                                      
REMARK 465     CYS B   711                                                      
REMARK 465     ILE B   712                                                      
REMARK 465     TRP B   713                                                      
REMARK 465     LYS B   714                                                      
REMARK 465     LEU B   715                                                      
REMARK 465     LEU B   716                                                      
REMARK 465     VAL B   717                                                      
REMARK 465     SER B   718                                                      
REMARK 465     PHE B   719                                                      
REMARK 465     HIS B   720                                                      
REMARK 465     ASP B   721                                                      
REMARK 465     ARG B   722                                                      
REMARK 465     LYS B   723                                                      
REMARK 465     GLU B   724                                                      
REMARK 465     VAL B   725                                                      
REMARK 465     ALA B   726                                                      
REMARK 465     LYS B   727                                                      
REMARK 465     PHE B   728                                                      
REMARK 465     GLU B   729                                                      
REMARK 465     ALA B   730                                                      
REMARK 465     GLU B   731                                                      
REMARK 465     ARG B   732                                                      
REMARK 465     SER B   733                                                      
REMARK 465     LYS B   734                                                      
REMARK 465     ALA B   735                                                      
REMARK 465     LYS B   736                                                      
REMARK 465     TRP B   737                                                      
REMARK 465     GLN B   738                                                      
REMARK 465     THR B   739                                                      
REMARK 465     GLY B   740                                                      
REMARK 465     THR B   741                                                      
REMARK 465     ASN B   742                                                      
REMARK 465     PRO B   743                                                      
REMARK 465     LEU B   744                                                      
REMARK 465     TYR B   745                                                      
REMARK 465     ARG B   746                                                      
REMARK 465     GLY B   747                                                      
REMARK 465     SER B   748                                                      
REMARK 465     THR B   749                                                      
REMARK 465     SER B   750                                                      
REMARK 465     THR B   751                                                      
REMARK 465     PHE B   752                                                      
REMARK 465     LYS B   753                                                      
REMARK 465     ASN B   754                                                      
REMARK 465     VAL B   755                                                      
REMARK 465     THR B   756                                                      
REMARK 465     TYR B   757                                                      
REMARK 465     LYS B   758                                                      
REMARK 465     HIS B   759                                                      
REMARK 465     ARG B   760                                                      
REMARK 465     GLU B   761                                                      
REMARK 465     LYS B   762                                                      
REMARK 465     GLN B   763                                                      
REMARK 465     LYS B   764                                                      
REMARK 465     VAL B   765                                                      
REMARK 465     ASP B   766                                                      
REMARK 465     LEU B   767                                                      
REMARK 465     SER B   768                                                      
REMARK 465     THR B   769                                                      
REMARK 465     ASP B   770                                                      
REMARK 465     CYS B   771                                                      
REMARK 465     ALA C    30                                                      
REMARK 465     SER C    31                                                      
REMARK 465     GLN C   504                                                      
REMARK 465     LYS C   505                                                      
REMARK 465     ALA C   569                                                      
REMARK 465     ASP C   570                                                      
REMARK 465     ASP C   595                                                      
REMARK 465     THR C   596                                                      
REMARK 465     GLY C   597                                                      
REMARK 465     GLY C   598                                                      
REMARK 465     LEU C   599                                                      
REMARK 465     GLU C   600                                                      
REMARK 465     VAL C   601                                                      
REMARK 465     LEU C   602                                                      
REMARK 465     PHE C   603                                                      
REMARK 465     GLN C   604                                                      
REMARK 465     GLY C   605                                                      
REMARK 465     PRO C   606                                                      
REMARK 465     GLY C   607                                                      
REMARK 465     GLU C   608                                                      
REMARK 465     ASN C   609                                                      
REMARK 465     ALA C   610                                                      
REMARK 465     GLN C   611                                                      
REMARK 465     LEU C   612                                                      
REMARK 465     GLU C   613                                                      
REMARK 465     LYS C   614                                                      
REMARK 465     GLU C   615                                                      
REMARK 465     LEU C   616                                                      
REMARK 465     GLN C   617                                                      
REMARK 465     ALA C   618                                                      
REMARK 465     LEU C   619                                                      
REMARK 465     GLU C   620                                                      
REMARK 465     LYS C   621                                                      
REMARK 465     GLU C   622                                                      
REMARK 465     ASN C   623                                                      
REMARK 465     ALA C   624                                                      
REMARK 465     GLN C   625                                                      
REMARK 465     LEU C   626                                                      
REMARK 465     GLU C   627                                                      
REMARK 465     TRP C   628                                                      
REMARK 465     GLU C   629                                                      
REMARK 465     LEU C   630                                                      
REMARK 465     GLN C   631                                                      
REMARK 465     ALA C   632                                                      
REMARK 465     LEU C   633                                                      
REMARK 465     GLU C   634                                                      
REMARK 465     LYS C   635                                                      
REMARK 465     GLU C   636                                                      
REMARK 465     LEU C   637                                                      
REMARK 465     ALA C   638                                                      
REMARK 465     GLN C   639                                                      
REMARK 465     THR C   640                                                      
REMARK 465     THR C   641                                                      
REMARK 465     GLY C   642                                                      
REMARK 465     TRP C   643                                                      
REMARK 465     ARG C   644                                                      
REMARK 465     GLY C   645                                                      
REMARK 465     GLY C   646                                                      
REMARK 465     HIS C   647                                                      
REMARK 465     VAL C   648                                                      
REMARK 465     VAL C   649                                                      
REMARK 465     GLU C   650                                                      
REMARK 465     GLY C   651                                                      
REMARK 465     LEU C   652                                                      
REMARK 465     ALA C   653                                                      
REMARK 465     GLY C   654                                                      
REMARK 465     GLU C   655                                                      
REMARK 465     LEU C   656                                                      
REMARK 465     GLU C   657                                                      
REMARK 465     GLN C   658                                                      
REMARK 465     LEU C   659                                                      
REMARK 465     ARG C   660                                                      
REMARK 465     ALA C   661                                                      
REMARK 465     ARG C   662                                                      
REMARK 465     LEU C   663                                                      
REMARK 465     GLU C   664                                                      
REMARK 465     HIS C   665                                                      
REMARK 465     HIS C   666                                                      
REMARK 465     PRO C   667                                                      
REMARK 465     GLN C   668                                                      
REMARK 465     GLY C   669                                                      
REMARK 465     GLN C   670                                                      
REMARK 465     ARG C   671                                                      
REMARK 465     GLU C   672                                                      
REMARK 465     PRO C   673                                                      
REMARK 465     ALA C   674                                                      
REMARK 465     GLY C   675                                                      
REMARK 465     HIS C   676                                                      
REMARK 465     HIS C   677                                                      
REMARK 465     HIS C   678                                                      
REMARK 465     HIS C   679                                                      
REMARK 465     HIS C   680                                                      
REMARK 465     HIS C   681                                                      
REMARK 465     MET D   -16                                                      
REMARK 465     GLY D   -15                                                      
REMARK 465     ILE D   -14                                                      
REMARK 465     GLU D   -13                                                      
REMARK 465     LEU D   -12                                                      
REMARK 465     LEU D   -11                                                      
REMARK 465     CYS D   -10                                                      
REMARK 465     LEU D    -9                                                      
REMARK 465     PHE D    -8                                                      
REMARK 465     PHE D    -7                                                      
REMARK 465     LEU D    -6                                                      
REMARK 465     PHE D    -5                                                      
REMARK 465     LEU D    -4                                                      
REMARK 465     GLY D    -3                                                      
REMARK 465     ARG D    -2                                                      
REMARK 465     ASN D    -1                                                      
REMARK 465     ASP D     0                                                      
REMARK 465     HIS D     1                                                      
REMARK 465     VAL D     2                                                      
REMARK 465     GLN D     3                                                      
REMARK 465     GLY D     4                                                      
REMARK 465     GLY D     9                                                      
REMARK 465     GLY D    10                                                      
REMARK 465     ALA D    11                                                      
REMARK 465     GLU D    12                                                      
REMARK 465     GLN D    29                                                      
REMARK 465     GLU D    30                                                      
REMARK 465     ASN D    31                                                      
REMARK 465     PHE D    32                                                      
REMARK 465     THR D    33                                                      
REMARK 465     HIS D    34                                                      
REMARK 465     PRO D    35                                                      
REMARK 465     SER D    36                                                      
REMARK 465     GLY D    37                                                      
REMARK 465     VAL D    38                                                      
REMARK 465     GLY D    39                                                      
REMARK 465     GLU D    40                                                      
REMARK 465     ALA D    46                                                      
REMARK 465     ASN D    47                                                      
REMARK 465     LEU D    48                                                      
REMARK 465     LEU D    49                                                      
REMARK 465     ALA D    50                                                      
REMARK 465     LYS D    51                                                      
REMARK 465     GLY D    52                                                      
REMARK 465     GLU D   442                                                      
REMARK 465     VAL D   443                                                      
REMARK 465     GLU D   444                                                      
REMARK 465     VAL D   445                                                      
REMARK 465     ASN D   446                                                      
REMARK 465     SER D   447                                                      
REMARK 465     SER D   448                                                      
REMARK 465     LYS D   449                                                      
REMARK 465     CYS D   450                                                      
REMARK 465     HIS D   451                                                      
REMARK 465     HIS D   452                                                      
REMARK 465     GLY D   453                                                      
REMARK 465     ASN D   454                                                      
REMARK 465     GLY D   455                                                      
REMARK 465     SER D   456                                                      
REMARK 465     PHE D   457                                                      
REMARK 465     GLN D   458                                                      
REMARK 465     CYS D   459                                                      
REMARK 465     GLY D   460                                                      
REMARK 465     VAL D   461                                                      
REMARK 465     CYS D   462                                                      
REMARK 465     ALA D   463                                                      
REMARK 465     CYS D   464                                                      
REMARK 465     HIS D   465                                                      
REMARK 465     PRO D   466                                                      
REMARK 465     GLY D   467                                                      
REMARK 465     HIS D   468                                                      
REMARK 465     MET D   469                                                      
REMARK 465     GLY D   470                                                      
REMARK 465     PRO D   471                                                      
REMARK 465     ARG D   472                                                      
REMARK 465     CYS D   473                                                      
REMARK 465     GLU D   474                                                      
REMARK 465     CYS D   475                                                      
REMARK 465     GLY D   476                                                      
REMARK 465     GLU D   477                                                      
REMARK 465     ASP D   478                                                      
REMARK 465     MET D   479                                                      
REMARK 465     LEU D   480                                                      
REMARK 465     SER D   481                                                      
REMARK 465     THR D   482                                                      
REMARK 465     ASP D   483                                                      
REMARK 465     SER D   484                                                      
REMARK 465     CYS D   485                                                      
REMARK 465     LYS D   486                                                      
REMARK 465     GLU D   487                                                      
REMARK 465     ALA D   488                                                      
REMARK 465     PRO D   489                                                      
REMARK 465     ASP D   490                                                      
REMARK 465     HIS D   491                                                      
REMARK 465     PRO D   492                                                      
REMARK 465     SER D   493                                                      
REMARK 465     CYS D   494                                                      
REMARK 465     SER D   495                                                      
REMARK 465     GLY D   496                                                      
REMARK 465     ARG D   497                                                      
REMARK 465     GLY D   498                                                      
REMARK 465     ASP D   499                                                      
REMARK 465     CYS D   500                                                      
REMARK 465     TYR D   501                                                      
REMARK 465     CYS D   502                                                      
REMARK 465     GLY D   503                                                      
REMARK 465     GLN D   504                                                      
REMARK 465     CYS D   505                                                      
REMARK 465     ILE D   506                                                      
REMARK 465     CYS D   507                                                      
REMARK 465     HIS D   508                                                      
REMARK 465     LEU D   509                                                      
REMARK 465     SER D   510                                                      
REMARK 465     PRO D   511                                                      
REMARK 465     TYR D   512                                                      
REMARK 465     GLY D   513                                                      
REMARK 465     ASN D   514                                                      
REMARK 465     ILE D   515                                                      
REMARK 465     TYR D   516                                                      
REMARK 465     GLY D   517                                                      
REMARK 465     PRO D   518                                                      
REMARK 465     TYR D   519                                                      
REMARK 465     CYS D   520                                                      
REMARK 465     GLN D   521                                                      
REMARK 465     CYS D   522                                                      
REMARK 465     ASP D   523                                                      
REMARK 465     ASN D   524                                                      
REMARK 465     PHE D   525                                                      
REMARK 465     SER D   526                                                      
REMARK 465     CYS D   527                                                      
REMARK 465     VAL D   528                                                      
REMARK 465     ARG D   529                                                      
REMARK 465     HIS D   530                                                      
REMARK 465     LYS D   531                                                      
REMARK 465     GLY D   532                                                      
REMARK 465     LEU D   533                                                      
REMARK 465     LEU D   534                                                      
REMARK 465     CYS D   535                                                      
REMARK 465     GLY D   536                                                      
REMARK 465     GLY D   537                                                      
REMARK 465     ASN D   538                                                      
REMARK 465     GLY D   539                                                      
REMARK 465     ASP D   540                                                      
REMARK 465     CYS D   541                                                      
REMARK 465     ASP D   542                                                      
REMARK 465     CYS D   543                                                      
REMARK 465     GLY D   544                                                      
REMARK 465     GLU D   545                                                      
REMARK 465     CYS D   546                                                      
REMARK 465     VAL D   547                                                      
REMARK 465     CYS D   548                                                      
REMARK 465     ARG D   549                                                      
REMARK 465     SER D   550                                                      
REMARK 465     GLY D   551                                                      
REMARK 465     TRP D   552                                                      
REMARK 465     THR D   553                                                      
REMARK 465     GLY D   554                                                      
REMARK 465     GLU D   555                                                      
REMARK 465     TYR D   556                                                      
REMARK 465     CYS D   557                                                      
REMARK 465     ASN D   558                                                      
REMARK 465     CYS D   559                                                      
REMARK 465     THR D   560                                                      
REMARK 465     THR D   561                                                      
REMARK 465     SER D   562                                                      
REMARK 465     THR D   563                                                      
REMARK 465     ASP D   564                                                      
REMARK 465     SER D   565                                                      
REMARK 465     CYS D   566                                                      
REMARK 465     VAL D   567                                                      
REMARK 465     SER D   568                                                      
REMARK 465     GLU D   569                                                      
REMARK 465     ASP D   570                                                      
REMARK 465     GLY D   571                                                      
REMARK 465     VAL D   572                                                      
REMARK 465     LEU D   573                                                      
REMARK 465     CYS D   574                                                      
REMARK 465     SER D   575                                                      
REMARK 465     GLY D   576                                                      
REMARK 465     ARG D   577                                                      
REMARK 465     GLY D   578                                                      
REMARK 465     ASP D   579                                                      
REMARK 465     CYS D   580                                                      
REMARK 465     VAL D   581                                                      
REMARK 465     CYS D   582                                                      
REMARK 465     GLY D   583                                                      
REMARK 465     LYS D   584                                                      
REMARK 465     CYS D   585                                                      
REMARK 465     VAL D   586                                                      
REMARK 465     CYS D   587                                                      
REMARK 465     THR D   588                                                      
REMARK 465     ASN D   589                                                      
REMARK 465     PRO D   590                                                      
REMARK 465     GLY D   591                                                      
REMARK 465     ALA D   592                                                      
REMARK 465     SER D   593                                                      
REMARK 465     GLY D   594                                                      
REMARK 465     PRO D   595                                                      
REMARK 465     THR D   596                                                      
REMARK 465     CYS D   597                                                      
REMARK 465     GLU D   598                                                      
REMARK 465     ARG D   599                                                      
REMARK 465     CYS D   600                                                      
REMARK 465     PRO D   601                                                      
REMARK 465     THR D   602                                                      
REMARK 465     CYS D   603                                                      
REMARK 465     GLY D   604                                                      
REMARK 465     ASP D   605                                                      
REMARK 465     PRO D   606                                                      
REMARK 465     CYS D   607                                                      
REMARK 465     ASN D   608                                                      
REMARK 465     SER D   609                                                      
REMARK 465     LYS D   610                                                      
REMARK 465     ARG D   611                                                      
REMARK 465     SER D   612                                                      
REMARK 465     CYS D   613                                                      
REMARK 465     ILE D   614                                                      
REMARK 465     GLU D   615                                                      
REMARK 465     CYS D   616                                                      
REMARK 465     HIS D   617                                                      
REMARK 465     LEU D   618                                                      
REMARK 465     SER D   619                                                      
REMARK 465     ALA D   620                                                      
REMARK 465     ALA D   621                                                      
REMARK 465     GLY D   622                                                      
REMARK 465     GLN D   623                                                      
REMARK 465     ALA D   624                                                      
REMARK 465     ARG D   625                                                      
REMARK 465     GLU D   626                                                      
REMARK 465     GLU D   627                                                      
REMARK 465     CYS D   628                                                      
REMARK 465     VAL D   629                                                      
REMARK 465     ASP D   630                                                      
REMARK 465     LYS D   631                                                      
REMARK 465     CYS D   632                                                      
REMARK 465     LYS D   633                                                      
REMARK 465     LEU D   634                                                      
REMARK 465     ALA D   635                                                      
REMARK 465     GLY D   636                                                      
REMARK 465     ALA D   637                                                      
REMARK 465     THR D   638                                                      
REMARK 465     ILE D   639                                                      
REMARK 465     SER D   640                                                      
REMARK 465     GLU D   641                                                      
REMARK 465     GLU D   642                                                      
REMARK 465     GLU D   643                                                      
REMARK 465     ASP D   644                                                      
REMARK 465     PHE D   645                                                      
REMARK 465     SER D   646                                                      
REMARK 465     LYS D   647                                                      
REMARK 465     ASP D   648                                                      
REMARK 465     GLY D   649                                                      
REMARK 465     SER D   650                                                      
REMARK 465     VAL D   651                                                      
REMARK 465     SER D   652                                                      
REMARK 465     CYS D   653                                                      
REMARK 465     SER D   654                                                      
REMARK 465     LEU D   655                                                      
REMARK 465     GLN D   656                                                      
REMARK 465     GLY D   657                                                      
REMARK 465     GLU D   658                                                      
REMARK 465     ASN D   659                                                      
REMARK 465     GLU D   660                                                      
REMARK 465     CYS D   661                                                      
REMARK 465     LEU D   662                                                      
REMARK 465     ILE D   663                                                      
REMARK 465     THR D   664                                                      
REMARK 465     PHE D   665                                                      
REMARK 465     LEU D   666                                                      
REMARK 465     ILE D   667                                                      
REMARK 465     THR D   668                                                      
REMARK 465     THR D   669                                                      
REMARK 465     ASP D   670                                                      
REMARK 465     ASN D   671                                                      
REMARK 465     GLU D   672                                                      
REMARK 465     GLY D   673                                                      
REMARK 465     LYS D   674                                                      
REMARK 465     THR D   675                                                      
REMARK 465     ILE D   676                                                      
REMARK 465     ILE D   677                                                      
REMARK 465     HIS D   678                                                      
REMARK 465     SER D   679                                                      
REMARK 465     ILE D   680                                                      
REMARK 465     ASN D   681                                                      
REMARK 465     GLU D   682                                                      
REMARK 465     LYS D   683                                                      
REMARK 465     ASP D   684                                                      
REMARK 465     CYS D   685                                                      
REMARK 465     PRO D   686                                                      
REMARK 465     LYS D   687                                                      
REMARK 465     PRO D   688                                                      
REMARK 465     PRO D   689                                                      
REMARK 465     ASN D   690                                                      
REMARK 465     ILE D   691                                                      
REMARK 465     PRO D   692                                                      
REMARK 465     MET D   693                                                      
REMARK 465     ILE D   694                                                      
REMARK 465     MET D   695                                                      
REMARK 465     LEU D   696                                                      
REMARK 465     GLY D   697                                                      
REMARK 465     VAL D   698                                                      
REMARK 465     SER D   699                                                      
REMARK 465     LEU D   700                                                      
REMARK 465     ALA D   701                                                      
REMARK 465     ILE D   702                                                      
REMARK 465     LEU D   703                                                      
REMARK 465     LEU D   704                                                      
REMARK 465     ILE D   705                                                      
REMARK 465     GLY D   706                                                      
REMARK 465     VAL D   707                                                      
REMARK 465     VAL D   708                                                      
REMARK 465     LEU D   709                                                      
REMARK 465     LEU D   710                                                      
REMARK 465     CYS D   711                                                      
REMARK 465     ILE D   712                                                      
REMARK 465     TRP D   713                                                      
REMARK 465     LYS D   714                                                      
REMARK 465     LEU D   715                                                      
REMARK 465     LEU D   716                                                      
REMARK 465     VAL D   717                                                      
REMARK 465     SER D   718                                                      
REMARK 465     PHE D   719                                                      
REMARK 465     HIS D   720                                                      
REMARK 465     ASP D   721                                                      
REMARK 465     ARG D   722                                                      
REMARK 465     LYS D   723                                                      
REMARK 465     GLU D   724                                                      
REMARK 465     VAL D   725                                                      
REMARK 465     ALA D   726                                                      
REMARK 465     LYS D   727                                                      
REMARK 465     PHE D   728                                                      
REMARK 465     GLU D   729                                                      
REMARK 465     ALA D   730                                                      
REMARK 465     GLU D   731                                                      
REMARK 465     ARG D   732                                                      
REMARK 465     SER D   733                                                      
REMARK 465     LYS D   734                                                      
REMARK 465     ALA D   735                                                      
REMARK 465     LYS D   736                                                      
REMARK 465     TRP D   737                                                      
REMARK 465     GLN D   738                                                      
REMARK 465     THR D   739                                                      
REMARK 465     GLY D   740                                                      
REMARK 465     THR D   741                                                      
REMARK 465     ASN D   742                                                      
REMARK 465     PRO D   743                                                      
REMARK 465     LEU D   744                                                      
REMARK 465     TYR D   745                                                      
REMARK 465     ARG D   746                                                      
REMARK 465     GLY D   747                                                      
REMARK 465     SER D   748                                                      
REMARK 465     THR D   749                                                      
REMARK 465     SER D   750                                                      
REMARK 465     THR D   751                                                      
REMARK 465     PHE D   752                                                      
REMARK 465     LYS D   753                                                      
REMARK 465     ASN D   754                                                      
REMARK 465     VAL D   755                                                      
REMARK 465     THR D   756                                                      
REMARK 465     TYR D   757                                                      
REMARK 465     LYS D   758                                                      
REMARK 465     HIS D   759                                                      
REMARK 465     ARG D   760                                                      
REMARK 465     GLU D   761                                                      
REMARK 465     LYS D   762                                                      
REMARK 465     GLN D   763                                                      
REMARK 465     LYS D   764                                                      
REMARK 465     VAL D   765                                                      
REMARK 465     ASP D   766                                                      
REMARK 465     LEU D   767                                                      
REMARK 465     SER D   768                                                      
REMARK 465     THR D   769                                                      
REMARK 465     ASP D   770                                                      
REMARK 465     CYS D   771                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     HIS B 408    CG   ND1  CD2  CE1  NE2                             
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OD1  ASN A   458     OG1  THR A   460              2.18            
REMARK 500   NH2  ARG B   109     OG1  THR B   397              2.19            
REMARK 500   OD2  ASP C   415     ND2  ASN C   417              2.09            
REMARK 500   O    TYR C   419     O    HOH C  4029              1.38            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS                                             
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC             
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15          
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A           
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375             
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE               
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.            
REMARK 500                                                                      
REMARK 500 DISTANCE CUTOFF:                                                     
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS              
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS                  
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE          
REMARK 500   OG   SER A   452     OG   SER C   452     4555     2.19            
REMARK 500   S    SO4 A  1598     S    SO4 A  1598     2555     0.59            
REMARK 500   S    SO4 A  1598     O1   SO4 A  1598     2555     1.89            
REMARK 500   S    SO4 A  1598     O3   SO4 A  1598     2555     1.77            
REMARK 500   S    SO4 A  1598     O4   SO4 A  1598     2555     1.49            
REMARK 500   S    SO4 A  1598     O2   SO4 A  1598     2555     0.99            
REMARK 500   O1   SO4 A  1598     O4   SO4 A  1598     2555     1.33            
REMARK 500   O1   SO4 A  1598     O2   SO4 A  1598     2555     1.86            
REMARK 500   O2   SO4 A  1598     O3   SO4 A  1598     2555     1.03            
REMARK 500   O2   SO4 A  1598     O4   SO4 A  1598     2555     1.53            
REMARK 500   O3   SO4 A  1598     O3   SO4 A  1598     2555     1.95            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ALA A  30     -130.68     64.82                                   
REMARK 500    SER A  63     -121.12     55.89                                   
REMARK 500    ARG A  65       51.90   -103.89                                   
REMARK 500    GLN A 102     -115.06     56.96                                   
REMARK 500    MET A 118      -67.49   -104.29                                   
REMARK 500    SER A 144     -163.61   -127.04                                   
REMARK 500    ASP A 148     -174.59     61.71                                   
REMARK 500    ASN A 206       42.96    -85.68                                   
REMARK 500    ALA A 213     -166.84   -118.53                                   
REMARK 500    LEU A 264      -76.10   -103.44                                   
REMARK 500    SER A 399      -40.42   -145.32                                   
REMARK 500    PRO B  98      104.45    -56.05                                   
REMARK 500    VAL B 161      -78.88   -138.64                                   
REMARK 500    ASP B 202       99.13    -68.09                                   
REMARK 500    SER B 216     -141.37    -98.65                                   
REMARK 500    HIS B 277       40.62   -140.88                                   
REMARK 500    ASP B 279     -169.82    -74.39                                   
REMARK 500    ASP B 365     -157.91    -73.25                                   
REMARK 500    ASN B 378     -142.29     56.36                                   
REMARK 500    HIS B 408     -154.24   -105.71                                   
REMARK 500    GLU B 410      169.47     64.12                                   
REMARK 500    SER C  63     -122.57     56.08                                   
REMARK 500    ARG C  65       53.45   -101.96                                   
REMARK 500    GLN C 102     -114.86     56.86                                   
REMARK 500    MET C 118      -62.74   -106.07                                   
REMARK 500    ASP C 132       55.01    -93.75                                   
REMARK 500    SER C 144     -165.62   -126.17                                   
REMARK 500    ASP C 148     -171.87     61.77                                   
REMARK 500    ASN C 206       47.51    -87.35                                   
REMARK 500    ALA C 213     -165.91   -118.30                                   
REMARK 500    ASN C 260       16.48   -140.27                                   
REMARK 500    LEU C 264      -76.84   -103.42                                   
REMARK 500    SER C 399      -38.22   -145.34                                   
REMARK 500    PRO D  89     -165.15    -79.40                                   
REMARK 500    PRO D  98      105.79    -55.93                                   
REMARK 500    VAL D 161      -78.26   -138.81                                   
REMARK 500    ASP D 202       99.20    -68.77                                   
REMARK 500    SER D 216      -66.80    -98.04                                   
REMARK 500    ASP D 279     -168.39    -74.88                                   
REMARK 500    GLU D 316       -2.99     69.15                                   
REMARK 500    ASP D 365     -160.48    -73.63                                   
REMARK 500    ASN D 378     -139.28   -128.47                                   
REMARK 500    CYS D 435      -19.74   -140.83                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             CAC B1442  AS                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CAC B1442   O1                                                     
REMARK 620 2 CAC B1442   O2  109.7                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             CAC D1442  AS                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CAC D1442   O1                                                     
REMARK 620 2 CAC D1442   O2  109.4                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG B2001  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP B 123   OD2                                                    
REMARK 620 2 GLU B 223   OE2  82.4                                              
REMARK 620 3 ASP B 254   OD1 102.7 147.3                                        
REMARK 620 4 SER B 125   OG   93.6 102.7 109.1                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG D2001  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP D 123   OD2                                                    
REMARK 620 2 SER D 125   OG   99.7                                              
REMARK 620 3 GLU D 223   OE2  86.0 104.6                                        
REMARK 620 4 ASP D 254   OD1 105.0  99.1 151.9                                  
REMARK 620 5 HOH D4003   O   167.8  83.4  81.8  86.1                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              NI A1599  NI                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS A 591   ND1                                                    
REMARK 620 2 HIS C 591   ND1 116.0                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA A2001  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP A 234   OD1                                                    
REMARK 620 2 HOH A4027   O    74.4                                              
REMARK 620 3 ILE A 236   O    91.8  92.3                                        
REMARK 620 4 ASN A 232   OD1  77.5  93.2 166.1                                  
REMARK 620 5 ASP A 238   OD2 147.4 117.9 116.3  71.9                            
REMARK 620 6 ASP A 238   OD1 140.5  67.6 100.0  93.9  54.5                      
REMARK 620 7 ASP A 230   OD1  73.0 144.8  75.9  92.4  96.8 146.4                
REMARK 620 N                    1     2     3     4     5     6                 
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA C2001  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP C 421   OD1                                                    
REMARK 620 2 ASP C 421   OD2  46.1                                              
REMARK 620 3 TYR C 419   O    85.2 105.0                                        
REMARK 620 4 ASP C 415   OD1 107.4  62.5 103.9                                  
REMARK 620 5 ASP C 415   OD2 115.0  80.6 153.3  54.8                            
REMARK 620 6 ASN C 417   OD1 155.3 143.5  70.4  83.1  89.4                      
REMARK 620 7 HOH C4029   O    89.5  84.3  33.8  70.7 124.3  72.6                
REMARK 620 N                    1     2     3     4     5     6                 
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA A2002  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP A 288   OD1                                                    
REMARK 620 2 HOH A4034   O    81.1                                              
REMARK 620 3 TYR A 290   O   105.2 129.3                                        
REMARK 620 4 ASP A 292   OD1 156.5  75.5  91.6                                  
REMARK 620 5 ASP A 292   OD2 137.2 113.9  95.3  54.5                            
REMARK 620 6 ASP A 284   OD1  66.6 146.9  69.5 136.1  87.1                      
REMARK 620 7 ASN A 286   OD1  63.2  92.3 136.2 114.9  75.9  67.2                
REMARK 620 N                    1     2     3     4     5     6                 
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA C2002  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP C 357   OD1                                                    
REMARK 620 2 ASP C 349   OD1 150.0                                              
REMARK 620 3 ASP C 351   OD1 106.5  88.7                                        
REMARK 620 4 ASP C 353   OD1 138.1  69.4  78.6                                  
REMARK 620 5 PHE C 355   O    93.9  71.4 159.3  88.8                            
REMARK 620 6 ASP C 357   OD2  55.4 106.8  74.8 153.2 115.8                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA A2003  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP A 349   OD1                                                    
REMARK 620 2 PHE A 355   O    70.0                                              
REMARK 620 3 ASP A 357   OD1 142.5  92.0                                        
REMARK 620 4 ASP A 357   OD2  99.3 109.3  54.8                                  
REMARK 620 5 ASP A 351   OD1  86.7 156.5 108.8  76.1                            
REMARK 620 6 ASP A 353   OD1  70.1  90.0 144.9 153.8  79.3                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA B2003  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP B 130   OD2                                                    
REMARK 620 2 LYS B 338   O    76.1                                              
REMARK 620 3 SER B 127   O   120.5 163.0                                        
REMARK 620 4 ASP B 130   OD1  46.8 107.8  84.2                                  
REMARK 620 5 ASP B 131   OD1  87.2  67.8 107.1  69.2                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA C2003  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP C 238   OD2                                                    
REMARK 620 2 ASP C 238   OD1  54.9                                              
REMARK 620 3 ASP C 230   OD1  90.2 136.9                                        
REMARK 620 4 ASN C 232   OD1  84.4 117.9  77.0                                  
REMARK 620 5 ASP C 234   OD1 146.4 155.6  66.6  67.5                            
REMARK 620 6 HOH C4010   O   118.3  83.5 139.1  77.4  74.3                      
REMARK 620 7 ILE C 236   O   110.2  95.6  71.8 145.3  86.2 118.0                
REMARK 620 N                    1     2     3     4     5     6                 
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA D2003  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 SER D 127   O                                                      
REMARK 620 2 ASP D 131   OD1  91.0                                              
REMARK 620 3 ASP D 130   OD1  76.2  62.5                                        
REMARK 620 4 ASP D 130   OD2 126.4  85.1  54.8                                  
REMARK 620 5 LYS D 338   O   149.1  61.2  99.7  68.1                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA A2004  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP A 413   OD1                                                    
REMARK 620 2 ASN A 417   OD1  58.9                                              
REMARK 620 3 TYR A 419   O    66.3  69.7                                        
REMARK 620 4 ASP A 415   OD1  63.5  86.6 129.8                                  
REMARK 620 5 ASP A 421   OD1  77.8 135.7  85.4  82.0                            
REMARK 620 6 ASP A 421   OD2 130.4 169.9 116.2  94.6  54.4                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA C2004  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP C 292   OD1                                                    
REMARK 620 2 ASP C 292   OD2  55.0                                              
REMARK 620 3 ASP C 284   OD1 139.2  90.7                                        
REMARK 620 4 ASN C 286   OD1 115.5  76.9  69.7                                  
REMARK 620 5 ASP C 288   OD1 155.5 136.5  64.6  61.4                            
REMARK 620 6 TYR C 290   O    90.0  96.9  71.4 140.4 107.0                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  CA A2001                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  CA A2002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  CA A2003                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  CA A2004                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  MG B2001                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  CA B2003                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  CA C2001                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  CA C2002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  CA C2003                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  CA C2004                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  MG D2001                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  CA D2003                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  CL C1595                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  CL A1595                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  CL C1596                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A1596                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A1597                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: BC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE SO4 A1598                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE  NI A1599                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CAC D1442                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR RESIDUE CAC B1442                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR POLY-SACCHARIDE                   
REMARK 800  RESIDUES NAG A3044  THROUGH MAN A3047  BOUND TO ASN A  44           
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR POLY-SACCHARIDE                   
REMARK 800  RESIDUES NAG A3260  THROUGH MAN A3264  BOUND TO ASN A 260           
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR POLY-SACCHARIDE                   
REMARK 800  RESIDUES NAG A3266  THROUGH MAN A3271  BOUND TO ASN A 266           
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR POLY-SACCHARIDE                   
REMARK 800  RESIDUES NAG A3458  THROUGH BMA A3460  BOUND TO ASN A 458           
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR POLY-SACCHARIDE                   
REMARK 800  RESIDUES NAG A3524  THROUGH MAN A3528  BOUND TO ASN A 524           
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: CC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR POLY-SACCHARIDE                   
REMARK 800  RESIDUES NAG A3585  THROUGH NAG A3586  BOUND TO ASN A 585           
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE                   
REMARK 800  NAG B3243  BOUND TO ASN B 243                                       
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR POLY-SACCHARIDE                   
REMARK 800  RESIDUES NAG C3044  THROUGH BMA C3046  BOUND TO ASN C  44           
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR POLY-SACCHARIDE                   
REMARK 800  RESIDUES NAG C3260  THROUGH NAG C3261  BOUND TO ASN C 260           
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR POLY-SACCHARIDE                   
REMARK 800  RESIDUES NAG C3266  THROUGH MAN C3271  BOUND TO ASN C 266           
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR POLY-SACCHARIDE                   
REMARK 800  RESIDUES NAG C3458  THROUGH MAN C3461  BOUND TO ASN C 458           
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR POLY-SACCHARIDE                   
REMARK 800  RESIDUES NAG C3524  THROUGH MAN C3530  BOUND TO ASN C 524           
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR POLY-SACCHARIDE                   
REMARK 800  RESIDUES NAG C3585  THROUGH NAG C3586  BOUND TO ASN C 585           
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE                   
REMARK 800  NAG D3080  BOUND TO ASN D  80                                       
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: DC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR MONO-SACCHARIDE                   
REMARK 800  NAG D3243  BOUND TO ASN D 243                                       
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: EC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: BINDING SITE FOR POLY-SACCHARIDE                   
REMARK 800  RESIDUES NAG D3370  THROUGH MAN D3373  BOUND TO ASN D 370           
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: 4UM9   RELATED DB: PDB                                   
REMARK 900  CRYSTAL STRUCTURE OF ALPHA V BETA 6 WITH PEPTIDE                    
DBREF  4UM8 A    1   595  UNP    P06756   ITAV_HUMAN      31    625             
DBREF  4UM8 B  -16   771  UNP    P18564   ITB6_HUMAN       1    788             
DBREF  4UM8 C    1   595  UNP    P06756   ITAV_HUMAN      31    625             
DBREF  4UM8 D  -16   771  UNP    P18564   ITB6_HUMAN       1    788             
SEQADV 4UM8 THR A  596  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY A  597  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY A  598  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU A  599  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU A  600  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 VAL A  601  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU A  602  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 PHE A  603  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN A  604  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY A  605  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 PRO A  606  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY A  607  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU A  608  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ASN A  609  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ALA A  610  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN A  611  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU A  612  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU A  613  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LYS A  614  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU A  615  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU A  616  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN A  617  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ALA A  618  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU A  619  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU A  620  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LYS A  621  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU A  622  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ASN A  623  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ALA A  624  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN A  625  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU A  626  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU A  627  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 TRP A  628  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU A  629  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU A  630  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN A  631  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ALA A  632  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU A  633  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU A  634  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LYS A  635  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU A  636  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU A  637  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ALA A  638  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN A  639  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 THR A  640  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 THR A  641  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY A  642  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 TRP A  643  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ARG A  644  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY A  645  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY A  646  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS A  647  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 VAL A  648  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 VAL A  649  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU A  650  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY A  651  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU A  652  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ALA A  653  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY A  654  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU A  655  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU A  656  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU A  657  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN A  658  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU A  659  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ARG A  660  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ALA A  661  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ARG A  662  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU A  663  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU A  664  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS A  665  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS A  666  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 PRO A  667  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN A  668  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY A  669  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN A  670  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ARG A  671  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU A  672  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 PRO A  673  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ALA A  674  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY A  675  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS A  676  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS A  677  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS A  678  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS A  679  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS A  680  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS A  681  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 CYS A  400  UNP  P06756    MET   430 ENGINEERED MUTATION            
SEQADV 4UM8 CYS B  270  UNP  P18564    ILE   287 ENGINEERED MUTATION            
SEQADV 4UM8 THR C  596  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY C  597  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY C  598  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU C  599  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU C  600  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 VAL C  601  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU C  602  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 PHE C  603  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN C  604  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY C  605  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 PRO C  606  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY C  607  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU C  608  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ASN C  609  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ALA C  610  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN C  611  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU C  612  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU C  613  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LYS C  614  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU C  615  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU C  616  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN C  617  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ALA C  618  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU C  619  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU C  620  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LYS C  621  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU C  622  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ASN C  623  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ALA C  624  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN C  625  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU C  626  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU C  627  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 TRP C  628  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU C  629  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU C  630  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN C  631  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ALA C  632  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU C  633  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU C  634  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LYS C  635  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU C  636  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU C  637  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ALA C  638  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN C  639  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 THR C  640  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 THR C  641  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY C  642  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 TRP C  643  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ARG C  644  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY C  645  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY C  646  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS C  647  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 VAL C  648  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 VAL C  649  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU C  650  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY C  651  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU C  652  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ALA C  653  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY C  654  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU C  655  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU C  656  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU C  657  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN C  658  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU C  659  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ARG C  660  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ALA C  661  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ARG C  662  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 LEU C  663  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU C  664  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS C  665  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS C  666  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 PRO C  667  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN C  668  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY C  669  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLN C  670  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ARG C  671  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLU C  672  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 PRO C  673  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 ALA C  674  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 GLY C  675  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS C  676  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS C  677  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS C  678  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS C  679  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS C  680  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 HIS C  681  UNP  P06756              EXPRESSION TAG                 
SEQADV 4UM8 CYS C  400  UNP  P06756    MET   430 ENGINEERED MUTATION            
SEQADV 4UM8 CYS D  270  UNP  P18564    ILE   287 ENGINEERED MUTATION            
SEQRES   1 A  681  PHE ASN LEU ASP VAL ASP SER PRO ALA GLU TYR SER GLY          
SEQRES   2 A  681  PRO GLU GLY SER TYR PHE GLY PHE ALA VAL ASP PHE PHE          
SEQRES   3 A  681  VAL PRO SER ALA SER SER ARG MET PHE LEU LEU VAL GLY          
SEQRES   4 A  681  ALA PRO LYS ALA ASN THR THR GLN PRO GLY ILE VAL GLU          
SEQRES   5 A  681  GLY GLY GLN VAL LEU LYS CYS ASP TRP SER SER THR ARG          
SEQRES   6 A  681  ARG CYS GLN PRO ILE GLU PHE ASP ALA THR GLY ASN ARG          
SEQRES   7 A  681  ASP TYR ALA LYS ASP ASP PRO LEU GLU PHE LYS SER HIS          
SEQRES   8 A  681  GLN TRP PHE GLY ALA SER VAL ARG SER LYS GLN ASP LYS          
SEQRES   9 A  681  ILE LEU ALA CYS ALA PRO LEU TYR HIS TRP ARG THR GLU          
SEQRES  10 A  681  MET LYS GLN GLU ARG GLU PRO VAL GLY THR CYS PHE LEU          
SEQRES  11 A  681  GLN ASP GLY THR LYS THR VAL GLU TYR ALA PRO CYS ARG          
SEQRES  12 A  681  SER GLN ASP ILE ASP ALA ASP GLY GLN GLY PHE CYS GLN          
SEQRES  13 A  681  GLY GLY PHE SER ILE ASP PHE THR LYS ALA ASP ARG VAL          
SEQRES  14 A  681  LEU LEU GLY GLY PRO GLY SER PHE TYR TRP GLN GLY GLN          
SEQRES  15 A  681  LEU ILE SER ASP GLN VAL ALA GLU ILE VAL SER LYS TYR          
SEQRES  16 A  681  ASP PRO ASN VAL TYR SER ILE LYS TYR ASN ASN GLN LEU          
SEQRES  17 A  681  ALA THR ARG THR ALA GLN ALA ILE PHE ASP ASP SER TYR          
SEQRES  18 A  681  LEU GLY TYR SER VAL ALA VAL GLY ASP PHE ASN GLY ASP          
SEQRES  19 A  681  GLY ILE ASP ASP PHE VAL SER GLY VAL PRO ARG ALA ALA          
SEQRES  20 A  681  ARG THR LEU GLY MET VAL TYR ILE TYR ASP GLY LYS ASN          
SEQRES  21 A  681  MET SER SER LEU TYR ASN PHE THR GLY GLU GLN MET ALA          
SEQRES  22 A  681  ALA TYR PHE GLY PHE SER VAL ALA ALA THR ASP ILE ASN          
SEQRES  23 A  681  GLY ASP ASP TYR ALA ASP VAL PHE ILE GLY ALA PRO LEU          
SEQRES  24 A  681  PHE MET ASP ARG GLY SER ASP GLY LYS LEU GLN GLU VAL          
SEQRES  25 A  681  GLY GLN VAL SER VAL SER LEU GLN ARG ALA SER GLY ASP          
SEQRES  26 A  681  PHE GLN THR THR LYS LEU ASN GLY PHE GLU VAL PHE ALA          
SEQRES  27 A  681  ARG PHE GLY SER ALA ILE ALA PRO LEU GLY ASP LEU ASP          
SEQRES  28 A  681  GLN ASP GLY PHE ASN ASP ILE ALA ILE ALA ALA PRO TYR          
SEQRES  29 A  681  GLY GLY GLU ASP LYS LYS GLY ILE VAL TYR ILE PHE ASN          
SEQRES  30 A  681  GLY ARG SER THR GLY LEU ASN ALA VAL PRO SER GLN ILE          
SEQRES  31 A  681  LEU GLU GLY GLN TRP ALA ALA ARG SER CYS PRO PRO SER          
SEQRES  32 A  681  PHE GLY TYR SER MET LYS GLY ALA THR ASP ILE ASP LYS          
SEQRES  33 A  681  ASN GLY TYR PRO ASP LEU ILE VAL GLY ALA PHE GLY VAL          
SEQRES  34 A  681  ASP ARG ALA ILE LEU TYR ARG ALA ARG PRO VAL ILE THR          
SEQRES  35 A  681  VAL ASN ALA GLY LEU GLU VAL TYR PRO SER ILE LEU ASN          
SEQRES  36 A  681  GLN ASP ASN LYS THR CYS SER LEU PRO GLY THR ALA LEU          
SEQRES  37 A  681  LYS VAL SER CYS PHE ASN VAL ARG PHE CYS LEU LYS ALA          
SEQRES  38 A  681  ASP GLY LYS GLY VAL LEU PRO ARG LYS LEU ASN PHE GLN          
SEQRES  39 A  681  VAL GLU LEU LEU LEU ASP LYS LEU LYS GLN LYS GLY ALA          
SEQRES  40 A  681  ILE ARG ARG ALA LEU PHE LEU TYR SER ARG SER PRO SER          
SEQRES  41 A  681  HIS SER LYS ASN MET THR ILE SER ARG GLY GLY LEU MET          
SEQRES  42 A  681  GLN CYS GLU GLU LEU ILE ALA TYR LEU ARG ASP GLU SER          
SEQRES  43 A  681  GLU PHE ARG ASP LYS LEU THR PRO ILE THR ILE PHE MET          
SEQRES  44 A  681  GLU TYR ARG LEU ASP TYR ARG THR ALA ALA ASP THR THR          
SEQRES  45 A  681  GLY LEU GLN PRO ILE LEU ASN GLN PHE THR PRO ALA ASN          
SEQRES  46 A  681  ILE SER ARG GLN ALA HIS ILE LEU LEU ASP THR GLY GLY          
SEQRES  47 A  681  LEU GLU VAL LEU PHE GLN GLY PRO GLY GLU ASN ALA GLN          
SEQRES  48 A  681  LEU GLU LYS GLU LEU GLN ALA LEU GLU LYS GLU ASN ALA          
SEQRES  49 A  681  GLN LEU GLU TRP GLU LEU GLN ALA LEU GLU LYS GLU LEU          
SEQRES  50 A  681  ALA GLN THR THR GLY TRP ARG GLY GLY HIS VAL VAL GLU          
SEQRES  51 A  681  GLY LEU ALA GLY GLU LEU GLU GLN LEU ARG ALA ARG LEU          
SEQRES  52 A  681  GLU HIS HIS PRO GLN GLY GLN ARG GLU PRO ALA GLY HIS          
SEQRES  53 A  681  HIS HIS HIS HIS HIS                                          
SEQRES   1 B  788  MET GLY ILE GLU LEU LEU CYS LEU PHE PHE LEU PHE LEU          
SEQRES   2 B  788  GLY ARG ASN ASP HIS VAL GLN GLY GLY CYS ALA LEU GLY          
SEQRES   3 B  788  GLY ALA GLU THR CYS GLU ASP CYS LEU LEU ILE GLY PRO          
SEQRES   4 B  788  GLN CYS ALA TRP CYS ALA GLN GLU ASN PHE THR HIS PRO          
SEQRES   5 B  788  SER GLY VAL GLY GLU ARG CYS ASP THR PRO ALA ASN LEU          
SEQRES   6 B  788  LEU ALA LYS GLY CYS GLN LEU ASN PHE ILE GLU ASN PRO          
SEQRES   7 B  788  VAL SER GLN VAL GLU ILE LEU LYS ASN LYS PRO LEU SER          
SEQRES   8 B  788  VAL GLY ARG GLN LYS ASN SER SER ASP ILE VAL GLN ILE          
SEQRES   9 B  788  ALA PRO GLN SER LEU ILE LEU LYS LEU ARG PRO GLY GLY          
SEQRES  10 B  788  ALA GLN THR LEU GLN VAL HIS VAL ARG GLN THR GLU ASP          
SEQRES  11 B  788  TYR PRO VAL ASP LEU TYR TYR LEU MET ASP LEU SER ALA          
SEQRES  12 B  788  SER MET ASP ASP ASP LEU ASN THR ILE LYS GLU LEU GLY          
SEQRES  13 B  788  SER ARG LEU SER LYS GLU MET SER LYS LEU THR SER ASN          
SEQRES  14 B  788  PHE ARG LEU GLY PHE GLY SER PHE VAL GLU LYS PRO VAL          
SEQRES  15 B  788  SER PRO PHE VAL LYS THR THR PRO GLU GLU ILE ALA ASN          
SEQRES  16 B  788  PRO CYS SER SER ILE PRO TYR PHE CYS LEU PRO THR PHE          
SEQRES  17 B  788  GLY PHE LYS HIS ILE LEU PRO LEU THR ASN ASP ALA GLU          
SEQRES  18 B  788  ARG PHE ASN GLU ILE VAL LYS ASN GLN LYS ILE SER ALA          
SEQRES  19 B  788  ASN ILE ASP THR PRO GLU GLY GLY PHE ASP ALA ILE MET          
SEQRES  20 B  788  GLN ALA ALA VAL CYS LYS GLU LYS ILE GLY TRP ARG ASN          
SEQRES  21 B  788  ASP SER LEU HIS LEU LEU VAL PHE VAL SER ASP ALA ASP          
SEQRES  22 B  788  SER HIS PHE GLY MET ASP SER LYS LEU ALA GLY ILE VAL          
SEQRES  23 B  788  CYS PRO ASN ASP GLY LEU CYS HIS LEU ASP SER LYS ASN          
SEQRES  24 B  788  GLU TYR SER MET SER THR VAL LEU GLU TYR PRO THR ILE          
SEQRES  25 B  788  GLY GLN LEU ILE ASP LYS LEU VAL GLN ASN ASN VAL LEU          
SEQRES  26 B  788  LEU ILE PHE ALA VAL THR GLN GLU GLN VAL HIS LEU TYR          
SEQRES  27 B  788  GLU ASN TYR ALA LYS LEU ILE PRO GLY ALA THR VAL GLY          
SEQRES  28 B  788  LEU LEU GLN LYS ASP SER GLY ASN ILE LEU GLN LEU ILE          
SEQRES  29 B  788  ILE SER ALA TYR GLU GLU LEU ARG SER GLU VAL GLU LEU          
SEQRES  30 B  788  GLU VAL LEU GLY ASP THR GLU GLY LEU ASN LEU SER PHE          
SEQRES  31 B  788  THR ALA ILE CYS ASN ASN GLY THR LEU PHE GLN HIS GLN          
SEQRES  32 B  788  LYS LYS CYS SER HIS MET LYS VAL GLY ASP THR ALA SER          
SEQRES  33 B  788  PHE SER VAL THR VAL ASN ILE PRO HIS CYS GLU ARG ARG          
SEQRES  34 B  788  SER ARG HIS ILE ILE ILE LYS PRO VAL GLY LEU GLY ASP          
SEQRES  35 B  788  ALA LEU GLU LEU LEU VAL SER PRO GLU CYS ASN CYS ASP          
SEQRES  36 B  788  CYS GLN LYS GLU VAL GLU VAL ASN SER SER LYS CYS HIS          
SEQRES  37 B  788  HIS GLY ASN GLY SER PHE GLN CYS GLY VAL CYS ALA CYS          
SEQRES  38 B  788  HIS PRO GLY HIS MET GLY PRO ARG CYS GLU CYS GLY GLU          
SEQRES  39 B  788  ASP MET LEU SER THR ASP SER CYS LYS GLU ALA PRO ASP          
SEQRES  40 B  788  HIS PRO SER CYS SER GLY ARG GLY ASP CYS TYR CYS GLY          
SEQRES  41 B  788  GLN CYS ILE CYS HIS LEU SER PRO TYR GLY ASN ILE TYR          
SEQRES  42 B  788  GLY PRO TYR CYS GLN CYS ASP ASN PHE SER CYS VAL ARG          
SEQRES  43 B  788  HIS LYS GLY LEU LEU CYS GLY GLY ASN GLY ASP CYS ASP          
SEQRES  44 B  788  CYS GLY GLU CYS VAL CYS ARG SER GLY TRP THR GLY GLU          
SEQRES  45 B  788  TYR CYS ASN CYS THR THR SER THR ASP SER CYS VAL SER          
SEQRES  46 B  788  GLU ASP GLY VAL LEU CYS SER GLY ARG GLY ASP CYS VAL          
SEQRES  47 B  788  CYS GLY LYS CYS VAL CYS THR ASN PRO GLY ALA SER GLY          
SEQRES  48 B  788  PRO THR CYS GLU ARG CYS PRO THR CYS GLY ASP PRO CYS          
SEQRES  49 B  788  ASN SER LYS ARG SER CYS ILE GLU CYS HIS LEU SER ALA          
SEQRES  50 B  788  ALA GLY GLN ALA ARG GLU GLU CYS VAL ASP LYS CYS LYS          
SEQRES  51 B  788  LEU ALA GLY ALA THR ILE SER GLU GLU GLU ASP PHE SER          
SEQRES  52 B  788  LYS ASP GLY SER VAL SER CYS SER LEU GLN GLY GLU ASN          
SEQRES  53 B  788  GLU CYS LEU ILE THR PHE LEU ILE THR THR ASP ASN GLU          
SEQRES  54 B  788  GLY LYS THR ILE ILE HIS SER ILE ASN GLU LYS ASP CYS          
SEQRES  55 B  788  PRO LYS PRO PRO ASN ILE PRO MET ILE MET LEU GLY VAL          
SEQRES  56 B  788  SER LEU ALA ILE LEU LEU ILE GLY VAL VAL LEU LEU CYS          
SEQRES  57 B  788  ILE TRP LYS LEU LEU VAL SER PHE HIS ASP ARG LYS GLU          
SEQRES  58 B  788  VAL ALA LYS PHE GLU ALA GLU ARG SER LYS ALA LYS TRP          
SEQRES  59 B  788  GLN THR GLY THR ASN PRO LEU TYR ARG GLY SER THR SER          
SEQRES  60 B  788  THR PHE LYS ASN VAL THR TYR LYS HIS ARG GLU LYS GLN          
SEQRES  61 B  788  LYS VAL ASP LEU SER THR ASP CYS                              
SEQRES   1 C  681  PHE ASN LEU ASP VAL ASP SER PRO ALA GLU TYR SER GLY          
SEQRES   2 C  681  PRO GLU GLY SER TYR PHE GLY PHE ALA VAL ASP PHE PHE          
SEQRES   3 C  681  VAL PRO SER ALA SER SER ARG MET PHE LEU LEU VAL GLY          
SEQRES   4 C  681  ALA PRO LYS ALA ASN THR THR GLN PRO GLY ILE VAL GLU          
SEQRES   5 C  681  GLY GLY GLN VAL LEU LYS CYS ASP TRP SER SER THR ARG          
SEQRES   6 C  681  ARG CYS GLN PRO ILE GLU PHE ASP ALA THR GLY ASN ARG          
SEQRES   7 C  681  ASP TYR ALA LYS ASP ASP PRO LEU GLU PHE LYS SER HIS          
SEQRES   8 C  681  GLN TRP PHE GLY ALA SER VAL ARG SER LYS GLN ASP LYS          
SEQRES   9 C  681  ILE LEU ALA CYS ALA PRO LEU TYR HIS TRP ARG THR GLU          
SEQRES  10 C  681  MET LYS GLN GLU ARG GLU PRO VAL GLY THR CYS PHE LEU          
SEQRES  11 C  681  GLN ASP GLY THR LYS THR VAL GLU TYR ALA PRO CYS ARG          
SEQRES  12 C  681  SER GLN ASP ILE ASP ALA ASP GLY GLN GLY PHE CYS GLN          
SEQRES  13 C  681  GLY GLY PHE SER ILE ASP PHE THR LYS ALA ASP ARG VAL          
SEQRES  14 C  681  LEU LEU GLY GLY PRO GLY SER PHE TYR TRP GLN GLY GLN          
SEQRES  15 C  681  LEU ILE SER ASP GLN VAL ALA GLU ILE VAL SER LYS TYR          
SEQRES  16 C  681  ASP PRO ASN VAL TYR SER ILE LYS TYR ASN ASN GLN LEU          
SEQRES  17 C  681  ALA THR ARG THR ALA GLN ALA ILE PHE ASP ASP SER TYR          
SEQRES  18 C  681  LEU GLY TYR SER VAL ALA VAL GLY ASP PHE ASN GLY ASP          
SEQRES  19 C  681  GLY ILE ASP ASP PHE VAL SER GLY VAL PRO ARG ALA ALA          
SEQRES  20 C  681  ARG THR LEU GLY MET VAL TYR ILE TYR ASP GLY LYS ASN          
SEQRES  21 C  681  MET SER SER LEU TYR ASN PHE THR GLY GLU GLN MET ALA          
SEQRES  22 C  681  ALA TYR PHE GLY PHE SER VAL ALA ALA THR ASP ILE ASN          
SEQRES  23 C  681  GLY ASP ASP TYR ALA ASP VAL PHE ILE GLY ALA PRO LEU          
SEQRES  24 C  681  PHE MET ASP ARG GLY SER ASP GLY LYS LEU GLN GLU VAL          
SEQRES  25 C  681  GLY GLN VAL SER VAL SER LEU GLN ARG ALA SER GLY ASP          
SEQRES  26 C  681  PHE GLN THR THR LYS LEU ASN GLY PHE GLU VAL PHE ALA          
SEQRES  27 C  681  ARG PHE GLY SER ALA ILE ALA PRO LEU GLY ASP LEU ASP          
SEQRES  28 C  681  GLN ASP GLY PHE ASN ASP ILE ALA ILE ALA ALA PRO TYR          
SEQRES  29 C  681  GLY GLY GLU ASP LYS LYS GLY ILE VAL TYR ILE PHE ASN          
SEQRES  30 C  681  GLY ARG SER THR GLY LEU ASN ALA VAL PRO SER GLN ILE          
SEQRES  31 C  681  LEU GLU GLY GLN TRP ALA ALA ARG SER CYS PRO PRO SER          
SEQRES  32 C  681  PHE GLY TYR SER MET LYS GLY ALA THR ASP ILE ASP LYS          
SEQRES  33 C  681  ASN GLY TYR PRO ASP LEU ILE VAL GLY ALA PHE GLY VAL          
SEQRES  34 C  681  ASP ARG ALA ILE LEU TYR ARG ALA ARG PRO VAL ILE THR          
SEQRES  35 C  681  VAL ASN ALA GLY LEU GLU VAL TYR PRO SER ILE LEU ASN          
SEQRES  36 C  681  GLN ASP ASN LYS THR CYS SER LEU PRO GLY THR ALA LEU          
SEQRES  37 C  681  LYS VAL SER CYS PHE ASN VAL ARG PHE CYS LEU LYS ALA          
SEQRES  38 C  681  ASP GLY LYS GLY VAL LEU PRO ARG LYS LEU ASN PHE GLN          
SEQRES  39 C  681  VAL GLU LEU LEU LEU ASP LYS LEU LYS GLN LYS GLY ALA          
SEQRES  40 C  681  ILE ARG ARG ALA LEU PHE LEU TYR SER ARG SER PRO SER          
SEQRES  41 C  681  HIS SER LYS ASN MET THR ILE SER ARG GLY GLY LEU MET          
SEQRES  42 C  681  GLN CYS GLU GLU LEU ILE ALA TYR LEU ARG ASP GLU SER          
SEQRES  43 C  681  GLU PHE ARG ASP LYS LEU THR PRO ILE THR ILE PHE MET          
SEQRES  44 C  681  GLU TYR ARG LEU ASP TYR ARG THR ALA ALA ASP THR THR          
SEQRES  45 C  681  GLY LEU GLN PRO ILE LEU ASN GLN PHE THR PRO ALA ASN          
SEQRES  46 C  681  ILE SER ARG GLN ALA HIS ILE LEU LEU ASP THR GLY GLY          
SEQRES  47 C  681  LEU GLU VAL LEU PHE GLN GLY PRO GLY GLU ASN ALA GLN          
SEQRES  48 C  681  LEU GLU LYS GLU LEU GLN ALA LEU GLU LYS GLU ASN ALA          
SEQRES  49 C  681  GLN LEU GLU TRP GLU LEU GLN ALA LEU GLU LYS GLU LEU          
SEQRES  50 C  681  ALA GLN THR THR GLY TRP ARG GLY GLY HIS VAL VAL GLU          
SEQRES  51 C  681  GLY LEU ALA GLY GLU LEU GLU GLN LEU ARG ALA ARG LEU          
SEQRES  52 C  681  GLU HIS HIS PRO GLN GLY GLN ARG GLU PRO ALA GLY HIS          
SEQRES  53 C  681  HIS HIS HIS HIS HIS                                          
SEQRES   1 D  788  MET GLY ILE GLU LEU LEU CYS LEU PHE PHE LEU PHE LEU          
SEQRES   2 D  788  GLY ARG ASN ASP HIS VAL GLN GLY GLY CYS ALA LEU GLY          
SEQRES   3 D  788  GLY ALA GLU THR CYS GLU ASP CYS LEU LEU ILE GLY PRO          
SEQRES   4 D  788  GLN CYS ALA TRP CYS ALA GLN GLU ASN PHE THR HIS PRO          
SEQRES   5 D  788  SER GLY VAL GLY GLU ARG CYS ASP THR PRO ALA ASN LEU          
SEQRES   6 D  788  LEU ALA LYS GLY CYS GLN LEU ASN PHE ILE GLU ASN PRO          
SEQRES   7 D  788  VAL SER GLN VAL GLU ILE LEU LYS ASN LYS PRO LEU SER          
SEQRES   8 D  788  VAL GLY ARG GLN LYS ASN SER SER ASP ILE VAL GLN ILE          
SEQRES   9 D  788  ALA PRO GLN SER LEU ILE LEU LYS LEU ARG PRO GLY GLY          
SEQRES  10 D  788  ALA GLN THR LEU GLN VAL HIS VAL ARG GLN THR GLU ASP          
SEQRES  11 D  788  TYR PRO VAL ASP LEU TYR TYR LEU MET ASP LEU SER ALA          
SEQRES  12 D  788  SER MET ASP ASP ASP LEU ASN THR ILE LYS GLU LEU GLY          
SEQRES  13 D  788  SER ARG LEU SER LYS GLU MET SER LYS LEU THR SER ASN          
SEQRES  14 D  788  PHE ARG LEU GLY PHE GLY SER PHE VAL GLU LYS PRO VAL          
SEQRES  15 D  788  SER PRO PHE VAL LYS THR THR PRO GLU GLU ILE ALA ASN          
SEQRES  16 D  788  PRO CYS SER SER ILE PRO TYR PHE CYS LEU PRO THR PHE          
SEQRES  17 D  788  GLY PHE LYS HIS ILE LEU PRO LEU THR ASN ASP ALA GLU          
SEQRES  18 D  788  ARG PHE ASN GLU ILE VAL LYS ASN GLN LYS ILE SER ALA          
SEQRES  19 D  788  ASN ILE ASP THR PRO GLU GLY GLY PHE ASP ALA ILE MET          
SEQRES  20 D  788  GLN ALA ALA VAL CYS LYS GLU LYS ILE GLY TRP ARG ASN          
SEQRES  21 D  788  ASP SER LEU HIS LEU LEU VAL PHE VAL SER ASP ALA ASP          
SEQRES  22 D  788  SER HIS PHE GLY MET ASP SER LYS LEU ALA GLY ILE VAL          
SEQRES  23 D  788  CYS PRO ASN ASP GLY LEU CYS HIS LEU ASP SER LYS ASN          
SEQRES  24 D  788  GLU TYR SER MET SER THR VAL LEU GLU TYR PRO THR ILE          
SEQRES  25 D  788  GLY GLN LEU ILE ASP LYS LEU VAL GLN ASN ASN VAL LEU          
SEQRES  26 D  788  LEU ILE PHE ALA VAL THR GLN GLU GLN VAL HIS LEU TYR          
SEQRES  27 D  788  GLU ASN TYR ALA LYS LEU ILE PRO GLY ALA THR VAL GLY          
SEQRES  28 D  788  LEU LEU GLN LYS ASP SER GLY ASN ILE LEU GLN LEU ILE          
SEQRES  29 D  788  ILE SER ALA TYR GLU GLU LEU ARG SER GLU VAL GLU LEU          
SEQRES  30 D  788  GLU VAL LEU GLY ASP THR GLU GLY LEU ASN LEU SER PHE          
SEQRES  31 D  788  THR ALA ILE CYS ASN ASN GLY THR LEU PHE GLN HIS GLN          
SEQRES  32 D  788  LYS LYS CYS SER HIS MET LYS VAL GLY ASP THR ALA SER          
SEQRES  33 D  788  PHE SER VAL THR VAL ASN ILE PRO HIS CYS GLU ARG ARG          
SEQRES  34 D  788  SER ARG HIS ILE ILE ILE LYS PRO VAL GLY LEU GLY ASP          
SEQRES  35 D  788  ALA LEU GLU LEU LEU VAL SER PRO GLU CYS ASN CYS ASP          
SEQRES  36 D  788  CYS GLN LYS GLU VAL GLU VAL ASN SER SER LYS CYS HIS          
SEQRES  37 D  788  HIS GLY ASN GLY SER PHE GLN CYS GLY VAL CYS ALA CYS          
SEQRES  38 D  788  HIS PRO GLY HIS MET GLY PRO ARG CYS GLU CYS GLY GLU          
SEQRES  39 D  788  ASP MET LEU SER THR ASP SER CYS LYS GLU ALA PRO ASP          
SEQRES  40 D  788  HIS PRO SER CYS SER GLY ARG GLY ASP CYS TYR CYS GLY          
SEQRES  41 D  788  GLN CYS ILE CYS HIS LEU SER PRO TYR GLY ASN ILE TYR          
SEQRES  42 D  788  GLY PRO TYR CYS GLN CYS ASP ASN PHE SER CYS VAL ARG          
SEQRES  43 D  788  HIS LYS GLY LEU LEU CYS GLY GLY ASN GLY ASP CYS ASP          
SEQRES  44 D  788  CYS GLY GLU CYS VAL CYS ARG SER GLY TRP THR GLY GLU          
SEQRES  45 D  788  TYR CYS ASN CYS THR THR SER THR ASP SER CYS VAL SER          
SEQRES  46 D  788  GLU ASP GLY VAL LEU CYS SER GLY ARG GLY ASP CYS VAL          
SEQRES  47 D  788  CYS GLY LYS CYS VAL CYS THR ASN PRO GLY ALA SER GLY          
SEQRES  48 D  788  PRO THR CYS GLU ARG CYS PRO THR CYS GLY ASP PRO CYS          
SEQRES  49 D  788  ASN SER LYS ARG SER CYS ILE GLU CYS HIS LEU SER ALA          
SEQRES  50 D  788  ALA GLY GLN ALA ARG GLU GLU CYS VAL ASP LYS CYS LYS          
SEQRES  51 D  788  LEU ALA GLY ALA THR ILE SER GLU GLU GLU ASP PHE SER          
SEQRES  52 D  788  LYS ASP GLY SER VAL SER CYS SER LEU GLN GLY GLU ASN          
SEQRES  53 D  788  GLU CYS LEU ILE THR PHE LEU ILE THR THR ASP ASN GLU          
SEQRES  54 D  788  GLY LYS THR ILE ILE HIS SER ILE ASN GLU LYS ASP CYS          
SEQRES  55 D  788  PRO LYS PRO PRO ASN ILE PRO MET ILE MET LEU GLY VAL          
SEQRES  56 D  788  SER LEU ALA ILE LEU LEU ILE GLY VAL VAL LEU LEU CYS          
SEQRES  57 D  788  ILE TRP LYS LEU LEU VAL SER PHE HIS ASP ARG LYS GLU          
SEQRES  58 D  788  VAL ALA LYS PHE GLU ALA GLU ARG SER LYS ALA LYS TRP          
SEQRES  59 D  788  GLN THR GLY THR ASN PRO LEU TYR ARG GLY SER THR SER          
SEQRES  60 D  788  THR PHE LYS ASN VAL THR TYR LYS HIS ARG GLU LYS GLN          
SEQRES  61 D  788  LYS VAL ASP LEU SER THR ASP CYS                              
HET     CA  A2001       1                                                       
HET     CA  A2002       1                                                       
HET     CA  A2003       1                                                       
HET     CA  A2004       1                                                       
HET    NAG  A3044      14                                                       
HET    NAG  A3045      14                                                       
HET    BMA  A3046      11                                                       
HET    MAN  A3047      11                                                       
HET    NAG  A3260      14                                                       
HET    NAG  A3261      14                                                       
HET    BMA  A3262      11                                                       
HET    MAN  A3263      11                                                       
HET    MAN  A3264      11                                                       
HET    NAG  A3266      14                                                       
HET    NAG  A3267      14                                                       
HET    BMA  A3268      11                                                       
HET    MAN  A3269      11                                                       
HET    MAN  A3270      11                                                       
HET    MAN  A3271      11                                                       
HET    NAG  A3458      14                                                       
HET    NAG  A3459      14                                                       
HET    BMA  A3460      11                                                       
HET    NAG  A3524      14                                                       
HET    NAG  A3525      14                                                       
HET    BMA  A3526      11                                                       
HET    MAN  A3527      11                                                       
HET    MAN  A3528      11                                                       
HET    NAG  A3585      14                                                       
HET    NAG  A3586      14                                                       
HET     MG  B2001       1                                                       
HET     CA  B2003       1                                                       
HET    NAG  B3243      14                                                       
HET     CA  C2001       1                                                       
HET     CA  C2002       1                                                       
HET     CA  C2003       1                                                       
HET     CA  C2004       1                                                       
HET    NAG  C3044      14                                                       
HET    NAG  C3045      14                                                       
HET    BMA  C3046      11                                                       
HET    NAG  C3260      14                                                       
HET    NAG  C3261      14                                                       
HET    NAG  C3266      14                                                       
HET    NAG  C3267      14                                                       
HET    BMA  C3268      11                                                       
HET    MAN  C3269      11                                                       
HET    MAN  C3270      11                                                       
HET    MAN  C3271      11                                                       
HET    NAG  C3458      14                                                       
HET    NAG  C3459      14                                                       
HET    BMA  C3460      11                                                       
HET    MAN  C3461      11                                                       
HET    NAG  C3524      14                                                       
HET    NAG  C3525      14                                                       
HET    BMA  C3526      11                                                       
HET    MAN  C3527      11                                                       
HET    MAN  C3528      11                                                       
HET    MAN  C3529      11                                                       
HET    MAN  C3530      11                                                       
HET    NAG  C3585      14                                                       
HET    NAG  C3586      14                                                       
HET     MG  D2001       1                                                       
HET     CA  D2003       1                                                       
HET    NAG  D3080      14                                                       
HET    NAG  D3243      14                                                       
HET    NAG  D3370      14                                                       
HET    NAG  D3371      14                                                       
HET    BMA  D3372      11                                                       
HET    MAN  D3373      11                                                       
HET     CL  C1595       1                                                       
HET     CL  A1595       1                                                       
HET     CL  C1596       1                                                       
HET    SO4  A1596       5                                                       
HET    SO4  A1597       5                                                       
HET    SO4  A1598       5                                                       
HET     NI  A1599       1                                                       
HET    CAC  D1442       5                                                       
HET    CAC  B1442       5                                                       
HETNAM     CAC CACODYLATE ION                                                   
HETNAM      MG MAGNESIUM ION                                                    
HETNAM     NAG N-ACETYL-D-GLUCOSAMINE                                           
HETNAM     SO4 SULFATE ION                                                      
HETNAM      CL CHLORIDE ION                                                     
HETNAM      NI NICKEL (II) ION                                                  
HETNAM     MAN ALPHA-D-MANNOSE                                                  
HETNAM     BMA BETA-D-MANNOSE                                                   
HETNAM      CA CALCIUM ION                                                      
HETSYN     CAC DIMETHYLARSINATE                                                 
FORMUL   4  CAC    2(C2 H6 AS O2 1-)                                            
FORMUL   5   MG    2(MG 2+)                                                     
FORMUL   6  NAG    29(C8 H15 N O6)                                              
FORMUL   7  SO4    3(O4 S 2-)                                                   
FORMUL   8   CL    3(CL 1-)                                                     
FORMUL   9   NI    NI 2+                                                        
FORMUL  10  MAN    17(C6 H12 O6)                                                
FORMUL  11  BMA    10(C6 H12 O6)                                                
FORMUL  12   CA    10(CA 2+)                                                    
FORMUL  13  HOH   *161(H2 O)                                                    
HELIX    1   1 GLY A  175  GLN A  180  1                                   6    
HELIX    2   2 VAL A  188  LYS A  194  1                                   7    
HELIX    3   3 GLN A  214  ASP A  218  5                                   5    
HELIX    4   4 ARG A  245  LEU A  250  1                                   6    
HELIX    5   5 GLY A  366  LYS A  370  5                                   5    
HELIX    6   6 PHE A  427  VAL A  429  5                                   3    
HELIX    7   7 ASP A  544  PHE A  548  5                                   5    
HELIX    8   8 THR B   13  LEU B   18  1                                   6    
HELIX    9   9 THR B   44  GLY B   52  1                                   9    
HELIX   10  10 ASN B   80  ILE B   84  5                                   5    
HELIX   11  11 SER B  125  SER B  127  5                                   3    
HELIX   12  12 MET B  128  ASN B  133  1                                   6    
HELIX   13  13 THR B  134  LYS B  136  5                                   3    
HELIX   14  14 GLU B  137  SER B  147  1                                  11    
HELIX   15  15 THR B  172  ASN B  178  1                                   7    
HELIX   16  16 ASP B  202  GLN B  213  1                                  12    
HELIX   17  17 GLY B  224  CYS B  235  1                                  12    
HELIX   18  18 CYS B  235  GLY B  240  1                                   6    
HELIX   19  19 PHE B  259  LEU B  265  5                                   7    
HELIX   20  20 THR B  294  ASN B  305  1                                  12    
HELIX   21  21 THR B  314  LYS B  326  1                                  13    
HELIX   22  22 ASN B  342  ARG B  355  1                                  14    
HELIX   23  23 CYS B  437  LYS B  441  5                                   5    
HELIX   24  24 GLY C  175  GLN C  180  1                                   6    
HELIX   25  25 VAL C  188  LYS C  194  1                                   7    
HELIX   26  26 GLN C  214  ASP C  218  5                                   5    
HELIX   27  27 ARG C  245  LEU C  250  1                                   6    
HELIX   28  28 GLY C  366  LYS C  370  5                                   5    
HELIX   29  29 PHE C  427  VAL C  429  5                                   3    
HELIX   30  30 ASP C  544  PHE C  548  5                                   5    
HELIX   31  31 THR D   13  LEU D   18  1                                   6    
HELIX   32  32 ASN D   80  ILE D   84  5                                   5    
HELIX   33  33 MET D  128  LYS D  136  1                                   9    
HELIX   34  34 LEU D  138  THR D  150  1                                  13    
HELIX   35  35 THR D  172  ASN D  178  1                                   7    
HELIX   36  36 ASP D  202  GLN D  213  1                                  12    
HELIX   37  37 GLY D  224  CYS D  235  1                                  12    
HELIX   38  38 CYS D  235  GLY D  240  1                                   6    
HELIX   39  39 PHE D  259  GLY D  267  5                                   9    
HELIX   40  40 THR D  294  ASN D  305  1                                  12    
HELIX   41  41 GLN D  317  LYS D  326  1                                  10    
HELIX   42  42 ASN D  342  ARG D  355  1                                  14    
HELIX   43  43 CYS D  437  LYS D  441  5                                   5    
SHEET    1  AA 4 ALA A   9  SER A  12  0                                        
SHEET    2  AA 4 ARG A 431  TYR A 435 -1  O  ALA A 432   N  TYR A  11           
SHEET    3  AA 4 ASP A 421  ALA A 426 -1  O  LEU A 422   N  TYR A 435           
SHEET    4  AA 4 MET A 408  THR A 412 -1  O  LYS A 409   N  ILE A 423           
SHEET    1  AB 4 VAL A  23  PHE A  26  0                                        
SHEET    2  AB 4 PHE A  35  ALA A  40 -1  O  PHE A  35   N  PHE A  26           
SHEET    3  AB 4 GLN A  55  ASP A  60 -1  O  GLN A  55   N  ALA A  40           
SHEET    4  AB 4 CYS A  67  PRO A  69 -1  O  GLN A  68   N  LYS A  58           
SHEET    1  AC 2 ASP A  79  ALA A  81  0                                        
SHEET    2  AC 2 ASP A  84  PRO A  85 -1  O  ASP A  84   N  TYR A  80           
SHEET    1  AD 2 GLU A  87  PHE A  88  0                                        
SHEET    2  AD 2 HIS A 113  TRP A 114 -1  O  HIS A 113   N  PHE A  88           
SHEET    1  AE 4 VAL A  98  LYS A 101  0                                        
SHEET    2  AE 4 LYS A 104  ALA A 109 -1  O  LYS A 104   N  LYS A 101           
SHEET    3  AE 4 THR A 127  GLN A 131 -1  O  THR A 127   N  ALA A 109           
SHEET    4  AE 4 THR A 136  TYR A 139 -1  O  VAL A 137   N  LEU A 130           
SHEET    1  AF 4 SER A 160  PHE A 163  0                                        
SHEET    2  AF 4 ARG A 168  GLY A 173 -1  O  LEU A 170   N  ASP A 162           
SHEET    3  AF 4 GLN A 182  GLN A 187 -1  O  GLN A 182   N  GLY A 173           
SHEET    4  AF 4 LEU A 208  ALA A 209 -1  O  LEU A 208   N  SER A 185           
SHEET    1  AG 4 VAL A 226  GLY A 229  0                                        
SHEET    2  AG 4 ASP A 238  VAL A 243 -1  O  ASP A 238   N  GLY A 229           
SHEET    3  AG 4 MET A 252  TYR A 256 -1  O  MET A 252   N  VAL A 243           
SHEET    4  AG 4 SER A 263  THR A 268 -1  N  LEU A 264   O  ILE A 255           
SHEET    1  AH 4 VAL A 280  ALA A 282  0                                        
SHEET    2  AH 4 VAL A 293  ALA A 297 -1  O  PHE A 294   N  ALA A 281           
SHEET    3  AH 4 GLN A 314  GLN A 320 -1  O  GLN A 314   N  ALA A 297           
SHEET    4  AH 4 PHE A 326  ASN A 332 -1  O  GLN A 327   N  LEU A 319           
SHEET    1  AI 2 MET A 301  ARG A 303  0                                        
SHEET    2  AI 2 LEU A 309  GLU A 311 -1  O  GLN A 310   N  ASP A 302           
SHEET    1  AJ 4 ILE A 344  GLY A 348  0                                        
SHEET    2  AJ 4 ASP A 357  ALA A 362 -1  O  ASP A 357   N  LEU A 347           
SHEET    3  AJ 4 ILE A 372  PHE A 376 -1  O  ILE A 372   N  ALA A 362           
SHEET    4  AJ 4 GLN A 389  GLU A 392 -1  O  GLN A 389   N  ILE A 375           
SHEET    1  AK 3 ALA A 481  GLY A 483  0                                        
SHEET    2  AK 3 VAL A 440  VAL A 443 -1  O  THR A 442   N  ASP A 482           
SHEET    3  AK 3 ILE A 577  LEU A 578  1  O  ILE A 577   N  ILE A 441           
SHEET    1  AL 4 GLY A 446  TYR A 450  0                                        
SHEET    2  AL 4 CYS A 472  LEU A 479 -1  O  ASN A 474   N  TYR A 450           
SHEET    3  AL 4 GLN A 534  LEU A 542 -1  O  GLN A 534   N  LEU A 479           
SHEET    4  AL 4 ALA A 511  PHE A 513 -1  O  LEU A 512   N  TYR A 541           
SHEET    1  AM 5 ILE A 453  LEU A 454  0                                        
SHEET    2  AM 5 ASN A 585  ILE A 592  1  O  HIS A 591   N  LEU A 454           
SHEET    3  AM 5 ILE A 555  LEU A 563 -1  O  ILE A 555   N  ALA A 590           
SHEET    4  AM 5 LYS A 490  LEU A 499 -1  O  GLN A 494   N  ARG A 562           
SHEET    5  AM 5 SER A 520  SER A 528 -1  O  HIS A 521   N  LEU A 497           
SHEET    1  BA 2 TRP B  26  CYS B  27  0                                        
SHEET    2  BA 2 ILE B  58  GLU B  59 -1  O  GLU B  59   N  TRP B  26           
SHEET    1  BB 6 GLN B  64  LYS B  69  0                                        
SHEET    2  BB 6 SER B  91  LEU B  96 -1  O  SER B  91   N  LEU B  68           
SHEET    3  BB 6 LEU B 427  PRO B 433  1  O  GLU B 428   N  LEU B  92           
SHEET    4  BB 6 ARG B 414  PRO B 420 -1  O  ARG B 414   N  VAL B 431           
SHEET    5  BB 6 VAL B 358  LEU B 363 -1  O  GLU B 361   N  LYS B 419           
SHEET    6  BB 6 LYS B 388  CYS B 389 -1  O  CYS B 389   N  VAL B 358           
SHEET    1  BC 5 ILE B  87  ALA B  88  0                                        
SHEET    2  BC 5 ALA B 101  VAL B 108 -1  O  HIS B 107   N  ALA B  88           
SHEET    3  BC 5 ALA B 398  ASN B 405 -1  O  ALA B 398   N  VAL B 108           
SHEET    4  BC 5 ASN B 370  CYS B 377 -1  O  ASN B 370   N  ASN B 405           
SHEET    5  BC 5 THR B 381  GLN B 384 -1  O  THR B 381   N  CYS B 377           
SHEET    1  BD 6 PHE B 193  THR B 200  0                                        
SHEET    2  BD 6 PHE B 153  PHE B 160 -1  O  LEU B 155   N  THR B 200           
SHEET    3  BD 6 VAL B 116  ASP B 123  1  O  VAL B 116   N  ARG B 154           
SHEET    4  BD 6 LEU B 246  SER B 253  1  O  LEU B 246   N  ASP B 117           
SHEET    5  BD 6 VAL B 307  VAL B 313  1  O  LEU B 308   N  LEU B 249           
SHEET    6  BD 6 THR B 332  LEU B 335  1  O  THR B 332   N  PHE B 311           
SHEET    1  CA 4 ALA C   9  SER C  12  0                                        
SHEET    2  CA 4 ARG C 431  TYR C 435 -1  O  ALA C 432   N  TYR C  11           
SHEET    3  CA 4 ASP C 421  ALA C 426 -1  O  LEU C 422   N  TYR C 435           
SHEET    4  CA 4 MET C 408  THR C 412 -1  O  LYS C 409   N  ILE C 423           
SHEET    1  CB 4 VAL C  23  PHE C  26  0                                        
SHEET    2  CB 4 PHE C  35  ALA C  40 -1  O  PHE C  35   N  PHE C  26           
SHEET    3  CB 4 GLN C  55  ASP C  60 -1  O  GLN C  55   N  ALA C  40           
SHEET    4  CB 4 CYS C  67  PRO C  69 -1  O  GLN C  68   N  LYS C  58           
SHEET    1  CC 2 ASP C  79  ALA C  81  0                                        
SHEET    2  CC 2 ASP C  84  PRO C  85 -1  O  ASP C  84   N  TYR C  80           
SHEET    1  CD 2 GLU C  87  PHE C  88  0                                        
SHEET    2  CD 2 HIS C 113  TRP C 114 -1  O  HIS C 113   N  PHE C  88           
SHEET    1  CE 4 VAL C  98  LYS C 101  0                                        
SHEET    2  CE 4 LYS C 104  ALA C 109 -1  O  LYS C 104   N  LYS C 101           
SHEET    3  CE 4 THR C 127  ASP C 132 -1  O  THR C 127   N  ALA C 109           
SHEET    4  CE 4 LYS C 135  TYR C 139 -1  O  LYS C 135   N  ASP C 132           
SHEET    1  CF 4 SER C 160  PHE C 163  0                                        
SHEET    2  CF 4 ARG C 168  GLY C 173 -1  O  LEU C 170   N  ASP C 162           
SHEET    3  CF 4 GLN C 182  GLN C 187 -1  O  GLN C 182   N  GLY C 173           
SHEET    4  CF 4 LEU C 208  ALA C 209 -1  O  LEU C 208   N  SER C 185           
SHEET    1  CG 4 VAL C 226  GLY C 229  0                                        
SHEET    2  CG 4 ASP C 238  VAL C 243 -1  O  ASP C 238   N  GLY C 229           
SHEET    3  CG 4 MET C 252  TYR C 256 -1  O  MET C 252   N  VAL C 243           
SHEET    4  CG 4 SER C 263  THR C 268 -1  N  LEU C 264   O  ILE C 255           
SHEET    1  CH 4 VAL C 280  THR C 283  0                                        
SHEET    2  CH 4 ASP C 292  ALA C 297 -1  O  ASP C 292   N  THR C 283           
SHEET    3  CH 4 GLN C 314  GLN C 320 -1  O  GLN C 314   N  ALA C 297           
SHEET    4  CH 4 PHE C 326  ASN C 332 -1  O  GLN C 327   N  LEU C 319           
SHEET    1  CI 2 MET C 301  ARG C 303  0                                        
SHEET    2  CI 2 LEU C 309  GLU C 311 -1  O  GLN C 310   N  ASP C 302           
SHEET    1  CJ 4 ILE C 344  GLY C 348  0                                        
SHEET    2  CJ 4 ASP C 357  ALA C 362 -1  O  ASP C 357   N  LEU C 347           
SHEET    3  CJ 4 ILE C 372  PHE C 376 -1  O  ILE C 372   N  ALA C 362           
SHEET    4  CJ 4 GLN C 389  GLU C 392 -1  O  GLN C 389   N  ILE C 375           
SHEET    1  CK 3 ALA C 481  GLY C 483  0                                        
SHEET    2  CK 3 VAL C 440  VAL C 443 -1  O  THR C 442   N  ASP C 482           
SHEET    3  CK 3 ILE C 577  LEU C 578  1  O  ILE C 577   N  ILE C 441           
SHEET    1  CL 4 GLY C 446  TYR C 450  0                                        
SHEET    2  CL 4 CYS C 472  LEU C 479 -1  O  ASN C 474   N  TYR C 450           
SHEET    3  CL 4 GLN C 534  LEU C 542 -1  O  GLN C 534   N  LEU C 479           
SHEET    4  CL 4 ALA C 511  PHE C 513 -1  O  LEU C 512   N  TYR C 541           
SHEET    1  CM 5 ILE C 453  LEU C 454  0                                        
SHEET    2  CM 5 ASN C 585  ILE C 592  1  O  HIS C 591   N  LEU C 454           
SHEET    3  CM 5 ILE C 555  LEU C 563 -1  O  ILE C 555   N  ALA C 590           
SHEET    4  CM 5 LYS C 490  LEU C 499 -1  O  GLN C 494   N  ARG C 562           
SHEET    5  CM 5 SER C 520  SER C 528 -1  O  HIS C 521   N  LEU C 497           
SHEET    1  DA 2 TRP D  26  CYS D  27  0                                        
SHEET    2  DA 2 ILE D  58  GLU D  59 -1  O  GLU D  59   N  TRP D  26           
SHEET    1  DB 6 GLN D  64  LYS D  69  0                                        
SHEET    2  DB 6 SER D  91  LEU D  96 -1  O  SER D  91   N  LEU D  68           
SHEET    3  DB 6 LEU D 427  PRO D 433  1  O  GLU D 428   N  LEU D  92           
SHEET    4  DB 6 ARG D 414  PRO D 420 -1  O  ARG D 414   N  VAL D 431           
SHEET    5  DB 6 VAL D 358  LEU D 363 -1  O  GLU D 361   N  LYS D 419           
SHEET    6  DB 6 LYS D 388  CYS D 389 -1  O  CYS D 389   N  VAL D 358           
SHEET    1  DC 5 ILE D  87  ALA D  88  0                                        
SHEET    2  DC 5 ALA D 101  VAL D 108 -1  O  HIS D 107   N  ALA D  88           
SHEET    3  DC 5 ALA D 398  ASN D 405 -1  O  ALA D 398   N  VAL D 108           
SHEET    4  DC 5 ASN D 370  ILE D 376 -1  O  ASN D 370   N  ASN D 405           
SHEET    5  DC 5 PHE D 383  GLN D 384 -1  O  PHE D 383   N  ALA D 375           
SHEET    1  DD 6 PHE D 193  THR D 200  0                                        
SHEET    2  DD 6 PHE D 153  PHE D 160 -1  O  LEU D 155   N  THR D 200           
SHEET    3  DD 6 VAL D 116  ASP D 123  1  O  VAL D 116   N  ARG D 154           
SHEET    4  DD 6 LEU D 246  SER D 253  1  O  LEU D 246   N  ASP D 117           
SHEET    5  DD 6 VAL D 307  VAL D 313  1  O  LEU D 308   N  LEU D 249           
SHEET    6  DD 6 THR D 332  LEU D 335  1  O  THR D 332   N  PHE D 311           
SSBOND   1 CYS A   59    CYS A   67                          1555   1555  2.03  
SSBOND   2 CYS A  108    CYS A  128                          1555   1555  2.03  
SSBOND   3 CYS A  142    CYS A  155                          1555   1555  2.03  
SSBOND   4 CYS A  400    CYS B  270                          1555   1555  2.03  
SSBOND   5 CYS A  461    CYS A  472                          1555   1555  2.03  
SSBOND   6 CYS A  478    CYS A  535                          1555   1555  2.03  
SSBOND   7 CYS B    6    CYS B   24                          1555   1555  2.03  
SSBOND   8 CYS B   14    CYS B  437                          1555   1555  2.03  
SSBOND   9 CYS B   17    CYS B   42                          1555   1555  2.03  
SSBOND  10 CYS B   27    CYS B   53                          1555   1555  2.03  
SSBOND  11 CYS B  180    CYS B  187                          1555   1555  2.03  
SSBOND  12 CYS B  235    CYS B  276                          1555   1555  2.03  
SSBOND  13 CYS B  377    CYS B  389                          1555   1555  2.03  
SSBOND  14 CYS B  409    CYS B  435                          1555   1555  2.03  
SSBOND  15 CYS C   59    CYS C   67                          1555   1555  2.03  
SSBOND  16 CYS C  108    CYS C  128                          1555   1555  2.03  
SSBOND  17 CYS C  142    CYS C  155                          1555   1555  2.03  
SSBOND  18 CYS C  400    CYS D  270                          1555   1555  2.03  
SSBOND  19 CYS C  461    CYS C  472                          1555   1555  2.03  
SSBOND  20 CYS C  478    CYS C  535                          1555   1555  2.03  
SSBOND  21 CYS D    6    CYS D   24                          1555   1555  2.03  
SSBOND  22 CYS D   14    CYS D  437                          1555   1555  2.03  
SSBOND  23 CYS D   17    CYS D   42                          1555   1555  2.03  
SSBOND  24 CYS D   27    CYS D   53                          1555   1555  2.03  
SSBOND  25 CYS D  180    CYS D  187                          1555   1555  2.03  
SSBOND  26 CYS D  235    CYS D  276                          1555   1555  2.03  
SSBOND  27 CYS D  377    CYS D  389                          1555   1555  2.03  
SSBOND  28 CYS D  409    CYS D  435                          1555   1555  2.03  
LINK         ND2 ASN A  44                 C1  NAG A3044     1555   1555  1.46  
LINK         ND2 ASN A 260                 C1  NAG A3260     1555   1555  1.44  
LINK         ND2 ASN A 266                 C1  NAG A3266     1555   1555  1.43  
LINK         ND2 ASN A 458                 C1  NAG A3458     1555   1555  1.43  
LINK         ND2 ASN A 524                 C1  NAG A3524     1555   1555  1.44  
LINK         ND2 ASN A 585                 C1  NAG A3585     1555   1555  1.44  
LINK        NI    NI A1599                 ND1 HIS A 591     1555   1555  1.97  
LINK        NI    NI A1599                 ND1 HIS C 591     1555   4555  2.40  
LINK        CA    CA A2001                 OD1 ASP A 234     1555   1555  2.41  
LINK        CA    CA A2001                 O   HOH A4027     1555   1555  2.38  
LINK        CA    CA A2001                 O   ILE A 236     1555   1555  2.22  
LINK        CA    CA A2001                 OD1 ASN A 232     1555   1555  2.30  
LINK        CA    CA A2001                 OD2 ASP A 238     1555   1555  2.43  
LINK        CA    CA A2001                 OD1 ASP A 238     1555   1555  2.36  
LINK        CA    CA A2001                 OD1 ASP A 230     1555   1555  2.35  
LINK        CA    CA A2002                 OD1 ASP A 288     1555   1555  2.41  
LINK        CA    CA A2002                 O   HOH A4034     1555   1555  2.40  
LINK        CA    CA A2002                 O   TYR A 290     1555   1555  2.25  
LINK        CA    CA A2002                 OD1 ASP A 292     1555   1555  2.37  
LINK        CA    CA A2002                 OD2 ASP A 292     1555   1555  2.42  
LINK        CA    CA A2002                 OD1 ASP A 284     1555   1555  2.37  
LINK        CA    CA A2002                 OD1 ASN A 286     1555   1555  2.33  
LINK        CA    CA A2003                 OD1 ASP A 349     1555   1555  2.41  
LINK        CA    CA A2003                 O   PHE A 355     1555   1555  2.22  
LINK        CA    CA A2003                 OD1 ASP A 357     1555   1555  2.36  
LINK        CA    CA A2003                 OD2 ASP A 357     1555   1555  2.41  
LINK        CA    CA A2003                 OD1 ASP A 351     1555   1555  2.31  
LINK        CA    CA A2003                 OD1 ASP A 353     1555   1555  2.34  
LINK        CA    CA A2004                 O   TYR A 419     1555   1555  2.28  
LINK        CA    CA A2004                 OD1 ASN A 417     1555   1555  2.41  
LINK        CA    CA A2004                 OD2 ASP A 421     1555   1555  2.39  
LINK        CA    CA A2004                 OD1 ASP A 413     1555   1555  3.03  
LINK        CA    CA A2004                 OD1 ASP A 421     1555   1555  2.40  
LINK        CA    CA A2004                 OD1 ASP A 415     1555   1555  2.30  
LINK         O4  NAG A3044                 C1  NAG A3045     1555   1555  1.44  
LINK         O4  NAG A3045                 C1  BMA A3046     1555   1555  1.44  
LINK         O6  BMA A3046                 C1  MAN A3047     1555   1555  1.44  
LINK         O4  NAG A3260                 C1  NAG A3261     1555   1555  1.44  
LINK         O4  NAG A3261                 C1  BMA A3262     1555   1555  1.44  
LINK         O6  BMA A3262                 C1  MAN A3263     1555   1555  1.44  
LINK         O3  MAN A3263                 C1  MAN A3264     1555   1555  1.44  
LINK         O4  NAG A3266                 C1  NAG A3267     1555   1555  1.42  
LINK         O4  NAG A3267                 C1  BMA A3268     1555   1555  1.43  
LINK         O3  BMA A3268                 C1  MAN A3269     1555   1555  1.44  
LINK         O6  BMA A3268                 C1  MAN A3270     1555   1555  1.44  
LINK         O3  MAN A3270                 C1  MAN A3271     1555   1555  1.44  
LINK         O4  NAG A3458                 C1  NAG A3459     1555   1555  1.43  
LINK         O4  NAG A3459                 C1  BMA A3460     1555   1555  1.46  
LINK         O4  NAG A3524                 C1  NAG A3525     1555   1555  1.44  
LINK         O4  NAG A3525                 C1  BMA A3526     1555   1555  1.44  
LINK         O6  BMA A3526                 C1  MAN A3527     1555   1555  1.44  
LINK         O6  MAN A3527                 C1  MAN A3528     1555   1555  1.44  
LINK         O4  NAG A3585                 C1  NAG A3586     1555   1555  1.44  
LINK         ND2 ASN B 243                 C1  NAG B3243     1555   1555  1.44  
LINK        MG    MG B2001                 OE2 GLU B 223     1555   1555  2.13  
LINK        MG    MG B2001                 OD1 ASP B 254     1555   1555  2.16  
LINK        MG    MG B2001                 OD2 ASP B 123     1555   1555  2.10  
LINK        MG    MG B2001                 OG  SER B 125     1555   1555  2.10  
LINK        CA    CA B2003                 O   SER B 127     1555   1555  2.41  
LINK        CA    CA B2003                 OD2 ASP B 130     1555   1555  2.97  
LINK        CA    CA B2003                 OD1 ASP B 130     1555   1555  2.38  
LINK        CA    CA B2003                 O   LYS B 338     1555   1555  2.46  
LINK        CA    CA B2003                 OD1 ASP B 131     1555   1555  2.39  
LINK         ND2 ASN C  44                 C1  NAG C3044     1555   1555  1.44  
LINK         ND2 ASN C 260                 C1  NAG C3260     1555   1555  1.44  
LINK         ND2 ASN C 266                 C1  NAG C3266     1555   1555  1.43  
LINK         ND2 ASN C 458                 C1  NAG C3458     1555   1555  1.43  
LINK         ND2 ASN C 524                 C1  NAG C3524     1555   1555  1.44  
LINK         ND2 ASN C 585                 C1  NAG C3585     1555   1555  1.44  
LINK        CA    CA C2001                 O   TYR C 419     1555   1555  2.37  
LINK        CA    CA C2001                 OD1 ASP C 415     1555   1555  2.34  
LINK        CA    CA C2001                 OD2 ASP C 421     1555   1555  3.02  
LINK        CA    CA C2001                 OD2 ASP C 415     1555   1555  2.42  
LINK        CA    CA C2001                 OD1 ASP C 421     1555   1555  2.36  
LINK        CA    CA C2001                 OD1 ASN C 417     1555   1555  2.40  
LINK        CA    CA C2001                 O   HOH C4029     1555   1555  2.35  
LINK        CA    CA C2002                 OD1 ASP C 349     1555   1555  2.41  
LINK        CA    CA C2002                 OD1 ASP C 353     1555   1555  2.33  
LINK        CA    CA C2002                 OD1 ASP C 357     1555   1555  2.37  
LINK        CA    CA C2002                 O   PHE C 355     1555   1555  2.18  
LINK        CA    CA C2002                 OD2 ASP C 357     1555   1555  2.36  
LINK        CA    CA C2002                 OD1 ASP C 351     1555   1555  2.34  
LINK        CA    CA C2003                 OD1 ASP C 230     1555   1555  2.35  
LINK        CA    CA C2003                 OD1 ASP C 238     1555   1555  2.36  
LINK        CA    CA C2003                 OD2 ASP C 238     1555   1555  2.40  
LINK        CA    CA C2003                 OD1 ASN C 232     1555   1555  2.40  
LINK        CA    CA C2003                 O   HOH C4010     1555   1555  2.40  
LINK        CA    CA C2003                 O   ILE C 236     1555   1555  2.49  
LINK        CA    CA C2003                 OD1 ASP C 234     1555   1555  2.37  
LINK        CA    CA C2004                 O   TYR C 290     1555   1555  2.25  
LINK        CA    CA C2004                 OD1 ASP C 288     1555   1555  2.39  
LINK        CA    CA C2004                 OD1 ASN C 286     1555   1555  2.35  
LINK        CA    CA C2004                 OD2 ASP C 292     1555   1555  2.38  
LINK        CA    CA C2004                 OD1 ASP C 292     1555   1555  2.37  
LINK        CA    CA C2004                 OD1 ASP C 284     1555   1555  2.38  
LINK         O4  NAG C3044                 C1  NAG C3045     1555   1555  1.44  
LINK         O4  NAG C3045                 C1  BMA C3046     1555   1555  1.44  
LINK         O4  NAG C3260                 C1  NAG C3261     1555   1555  1.44  
LINK         O4  NAG C3266                 C1  NAG C3267     1555   1555  1.42  
LINK         O4  NAG C3267                 C1  BMA C3268     1555   1555  1.43  
LINK         O6  BMA C3268                 C1  MAN C3270     1555   1555  1.44  
LINK         O3  BMA C3268                 C1  MAN C3269     1555   1555  1.44  
LINK         O3  MAN C3270                 C1  MAN C3271     1555   1555  1.44  
LINK         O4  NAG C3458                 C1  NAG C3459     1555   1555  1.43  
LINK         O4  NAG C3459                 C1  BMA C3460     1555   1555  1.44  
LINK         O3  BMA C3460                 C1  MAN C3461     1555   1555  1.44  
LINK         O4  NAG C3524                 C1  NAG C3525     1555   1555  1.44  
LINK         O4  NAG C3525                 C1  BMA C3526     1555   1555  1.44  
LINK         O3  BMA C3526                 C1  MAN C3528     1555   1555  1.44  
LINK         O6  BMA C3526                 C1  MAN C3527     1555   1555  1.45  
LINK         O6  MAN C3527                 C1  MAN C3529     1555   1555  1.44  
LINK         O3  MAN C3527                 C1  MAN C3530     1555   1555  1.44  
LINK         O4  NAG C3585                 C1  NAG C3586     1555   1555  1.44  
LINK         ND2 ASN D  80                 C1  NAG D3080     1555   1555  1.44  
LINK         ND2 ASN D 243                 C1  NAG D3243     1555   1555  1.44  
LINK         ND2 ASN D 370                 C1  NAG D3370     1555   1555  1.44  
LINK        MG    MG D2001                 OD1 ASP D 254     1555   1555  2.12  
LINK        MG    MG D2001                 OE2 GLU D 223     1555   1555  2.10  
LINK        MG    MG D2001                 OG  SER D 125     1555   1555  2.09  
LINK        MG    MG D2001                 OD2 ASP D 123     1555   1555  2.08  
LINK        MG    MG D2001                 O   HOH D4003     1555   1555  2.07  
LINK        CA    CA D2003                 O   LYS D 338     1555   1555  2.49  
LINK        CA    CA D2003                 OD2 ASP D 130     1555   1555  2.41  
LINK        CA    CA D2003                 OD1 ASP D 130     1555   1555  2.36  
LINK        CA    CA D2003                 OD1 ASP D 131     1555   1555  2.96  
LINK        CA    CA D2003                 O   SER D 127     1555   1555  2.42  
LINK         O4  NAG D3370                 C1  NAG D3371     1555   1555  1.43  
LINK         O4  NAG D3371                 C1  BMA D3372     1555   1555  1.44  
LINK         O6  BMA D3372                 C1  MAN D3373     1555   1555  1.44  
CISPEP   1 TYR A  450    PRO A  451          0        -2.90                     
CISPEP   2 ALA B   88    PRO B   89          0        -1.70                     
CISPEP   3 SER B  166    PRO B  167          0         2.28                     
CISPEP   4 ILE B  183    PRO B  184          0        -4.52                     
CISPEP   5 TYR C  450    PRO C  451          0        -1.94                     
CISPEP   6 ALA D   88    PRO D   89          0        -0.46                     
CISPEP   7 SER D  166    PRO D  167          0         2.60                     
CISPEP   8 ILE D  183    PRO D  184          0        -4.51                     
SITE     1 AC1  6 ASP A 230  ASN A 232  ASP A 234  ILE A 236                    
SITE     2 AC1  6 ASP A 238  HOH A4027                                          
SITE     1 AC2  6 ASP A 284  ASN A 286  ASP A 288  TYR A 290                    
SITE     2 AC2  6 ASP A 292  HOH A4034                                          
SITE     1 AC3  5 ASP A 349  ASP A 351  ASP A 353  PHE A 355                    
SITE     2 AC3  5 ASP A 357                                                     
SITE     1 AC4  5 ASP A 413  ASP A 415  ASN A 417  TYR A 419                    
SITE     2 AC4  5 ASP A 421                                                     
SITE     1 AC5  4 ASP B 123  SER B 125  GLU B 223  ASP B 254                    
SITE     1 AC6  4 SER B 127  ASP B 130  ASP B 131  LYS B 338                    
SITE     1 AC7  5 ASP C 415  ASN C 417  TYR C 419  ASP C 421                    
SITE     2 AC7  5 HOH C4029                                                     
SITE     1 AC8  5 ASP C 349  ASP C 351  ASP C 353  PHE C 355                    
SITE     2 AC8  5 ASP C 357                                                     
SITE     1 AC9  7 ASP C 230  ASN C 232  ASP C 234  ILE C 236                    
SITE     2 AC9  7 ASP C 238  ASP C 257  HOH C4010                               
SITE     1 BC1  5 ASP C 284  ASN C 286  ASP C 288  TYR C 290                    
SITE     2 BC1  5 ASP C 292                                                     
SITE     1 BC2  5 ASP D 123  SER D 125  GLU D 223  ASP D 254                    
SITE     2 BC2  5 HOH D4003                                                     
SITE     1 BC3  4 SER D 127  ASP D 130  ASP D 131  LYS D 338                    
SITE     1 BC4  2 SER C 528  LEU C 532                                          
SITE     1 BC5  2 ASN A  77  SER A  90                                          
SITE     1 BC6  2 ASN C  77  SER C  90                                          
SITE     1 BC7  2 PRO A 488  ARG A 489                                          
SITE     1 BC8  4 PHE A 337  LYS A 369  HOH A4037  PRO B 271                    
SITE     1 BC9  2 GLY A 418  GLY A 485                                          
SITE     1 CC1  2 HIS A 591  HIS C 591                                          
SITE     1 CC2  4 PRO D  89  LEU D  92  LEU D 104  GLN D 105                    
SITE     1 CC3  4 VAL B  65  THR B 103  LEU B 104  GLN B 105                    
SITE     1 CC4  6 GLU A  15  GLY A  16  SER A  17  LYS A  42                    
SITE     2 CC4  6 ASN A  44  GLU A  52                                          
SITE     1 CC5  5 ASP A 257  LYS A 259  ASN A 260  TYR A 265                    
SITE     2 CC5  5 GLY A 324                                                     
SITE     1 CC6  7 ARG A 211  GLN A 214  PHE A 217  TYR A 254                    
SITE     2 CC6  7 SER A 263  LEU A 264  ASN A 266                               
SITE     1 CC7  7 ASN A 458  THR A 460  CYS A 461  CYS A 472                    
SITE     2 CC7  7 PHE A 473  ASN A 474  MAN C3461                               
SITE     1 CC8  8 ASN A 524  ASP A 564  HOH A4065  GLU C  10                    
SITE     2 CC8  8 SER C  12  ARG C  65  ARG C 431  HOH C4027                    
SITE     1 CC9  2 PRO A 583  ASN A 585                                          
SITE     1 DC1  1 ASN B 243                                                     
SITE     1 DC2  5 GLU C  15  GLY C  16  SER C  17  LYS C  42                    
SITE     2 DC2  5 ASN C  44                                                     
SITE     1 DC3  3 ASP C 257  LYS C 259  ASN C 260                               
SITE     1 DC4  7 ARG C 211  GLN C 214  PHE C 217  TYR C 254                    
SITE     2 DC4  7 SER C 263  LEU C 264  ASN C 266                               
SITE     1 DC5  9 GLU A 448  TYR A 450  NAG A3459  BMA A3460                    
SITE     2 DC5  9 ASN C 458  THR C 460  CYS C 472  ASN C 474                    
SITE     3 DC5  9 HOH C4035                                                     
SITE     1 DC6 12 GLU A  10  SER A  12  GLY A  13  GLU A  15                    
SITE     2 DC6 12 LEU A  57  ARG A  65  ARG A  66  CYS A  67                    
SITE     3 DC6 12 ARG A 398  ARG A 431  ASN C 492  ASN C 524                    
SITE     1 DC7  3 GLU C 560  PRO C 583  ASN C 585                               
SITE     1 DC8  4 ASN D  80  SER D  82  HOH D4021  HOH D4022                    
SITE     1 DC9  2 ASN D 243  HOH D4013                                          
SITE     1 EC1  9 ASN B 212  LYS B 214  SER C 305  LYS C 330                    
SITE     2 EC1  9 LEU C 331  ASN C 332  ASN D 370  PRO D 407                    
SITE     3 EC1  9 HOH D4023                                                     
CRYST1  184.450  170.010  102.390  90.00  98.68  90.00 C 1 2 1       1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.005422  0.000000  0.000828        0.00000                         
SCALE2      0.000000  0.005882  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.009880        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system